851 lines
37 KiB
Text
851 lines
37 KiB
Text
|
||
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr">
|
||
<head>
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="Retinopathy of prematurity (ROP), which causes abnormal blood vessels to grow in a baby’s retina (light-sensitive layer of tissue at the back of the eye), is a cause of vision loss in the United States. Clinical studies funded by NEI provide people the information they need to make informed health care decisions about their eyes." />
|
||
<meta name="google" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw,lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
||
<meta name="google-site-verification" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw" />
|
||
<meta name="google-site-verification" content="lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
||
<meta name="google-site-verification" content="UDfyeEAWNX_rJUHwog9j1kziEnByGwhkSJGLJclUWDA" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<script type="application/ld+json">{
|
||
"@context": "https://schema.org",
|
||
"@graph": [
|
||
{
|
||
"@type": "WebPage",
|
||
"@id": "https://www.nei.nih.gov/research/clinical-trials/landmark-clinical-vision-and-eye-research/retinopathy-prematurity-research",
|
||
"breadcrumb": {
|
||
"@type": "BreadcrumbList",
|
||
"itemListElement": [
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 1,
|
||
"name": "Home",
|
||
"item": "https://www.nei.nih.gov/"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 2,
|
||
"name": "Research at NEI",
|
||
"item": "https://www.nei.nih.gov/research"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 3,
|
||
"name": "Clinical Trials",
|
||
"item": "https://www.nei.nih.gov/research/clinical-trials"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 4,
|
||
"name": "Landmark Clinical Vision and Eye Research ",
|
||
"item": "https://www.nei.nih.gov/research/clinical-trials/landmark-clinical-vision-and-eye-research"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 5,
|
||
"name": "Retinopathy of Prematurity Research ",
|
||
"item": "https://www.nei.nih.gov/research/clinical-trials/landmark-clinical-vision-and-eye-research/retinopathy-prematurity-research"
|
||
}
|
||
]
|
||
},
|
||
"author": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
},
|
||
"publisher": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
}
|
||
}
|
||
]
|
||
}</script>
|
||
<link rel="icon" type="image/png" href="/themes/custom/nei/images/favicon.png" />
|
||
<link rel="apple-touch-icon" href="/themes/custom/nei/images/apple-touch-icon.png" />
|
||
<meta name="last-updated" content="Dec 16, 2024, 4:27:46 PM" />
|
||
<link rel="icon" href="/themes/custom/nei/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<link rel="alternate" hreflang="en" href="https://www.nei.nih.gov/research/clinical-trials/landmark-clinical-vision-and-eye-research/retinopathy-prematurity-research" />
|
||
<link rel="canonical" href="https://www.nei.nih.gov/research/clinical-trials/landmark-clinical-vision-and-eye-research/retinopathy-prematurity-research" />
|
||
<link rel="shortlink" href="https://www.nei.nih.gov/node/3950" />
|
||
|
||
<title>Retinopathy of Prematurity Research</title>
|
||
<link rel="preload" href="/themes/custom/nei/fonts/Aleo-Bold.woff2" as="font" type="font/woff2" crossorigin>
|
||
<link rel="preload" href="/themes/custom/nei/fonts/Lato-Regular.woff2" as="font" type="font/woff2" crossorigin>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_PGSk_7b88hq2qr_--_38MLvoj1ffr9jv3JhnNJTnKUM.css?delta=0&language=en&theme=nei&include=eJw1ytEKgCAMRuEXsnwk-dMxrOliTqi3j4iuDnycfFCprpbyHK4tDb-FRvwSshrFYvOErNhxBUHnCaYEcbJ_61Qji26Q5ZXa-QH_YCJ9" />
|
||
<link rel="stylesheet" media="all" href="/themes/custom/nei/css/style.css?sraguf" />
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/3950","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxdjFsOwjAMBC8U6iNFbmKZgPNQ7BTK6SmgCsrPrndkTbhSTFa7D0OtZq-2Cil8yoWOj5WYYT8c18pC3pCBt_jfE17wfoTZCRYeyORRjPruLmhpIS-b2EvFmArD73CFErDUGeWkoadmekCb5fXVsCN3bGeF2EdDmb5kGqWNWZKeKTpd1SjDjEpuSXRTeOeUaxxCT9WYZ50","theme":"nei","theme_token":null},"ajaxTrustedUrl":{"form_action_p_pvdeGsVG5zNF_XLGPTvYSKCf43t8qZYSwcfZl2uzM":true},"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"google\nnonGooglePixels\nnonGoogleScripts\nnonGoogleIframes","blocklist_classes":"customScripts\ncustomPixels","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-TLVNS7W"]},"user":{"uid":0,"permissionsHash":"c48594e108b5c1c2bea409821b71477d5bc2724c8cae6d31f1d985af0daab85c"}}</script>
|
||
<script src="/sites/default/files/js/js_WgzMsgqb-MiW-Z2aLffGQHepZwX2hWrEHSrb46WqZrk.js?scope=header&delta=0&language=en&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
||
<script src="https://script.crazyegg.com/pages/scripts/0117/6571.js" async></script>
|
||
<script src="/modules/contrib/google_tag/js/gtag.js?sraguf"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtm.js?sraguf"></script>
|
||
|
||
</head>
|
||
<body class="t-page t-node__3950 path-research-clinical-trials-landmark-clinical-vision-and-eye-research-retinopathy-prematurity-research">
|
||
<a href="#main-content" class="u-skip-link">
|
||
Skip to content
|
||
</a>
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-TLVNS7W"
|
||
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<div id="u-page-outer" class="u-outer">
|
||
<div class="views-element-container site-notice-block" id="block-views-block-site-notices-block-1">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="js-view-dom-id-72cc1632abbd95ff8cb03c6ae8981e019774d612a073afaf82d31d2acd4b8a84 site-notices">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<img src="/themes/custom/nei/images/NEI-logo-tagline.svg" alt="" width="200" height="48" class="u-print-only">
|
||
<div class="r-global-header">
|
||
<div id="r-header-outer" class="r-header">
|
||
|
||
<div class="r-header-inner">
|
||
|
||
<div id="block-nei-branding" class="o-block--logo" role="banner">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-logo">
|
||
<a href="/" class="o-logo__link" title="Home" rel="home"><span class="o-logo__text">National Eye Institute</span> <span class="o-logo__tagline">Research Today… Vision Tomorrow</span></a>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div id="block-neimenubutton-2">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-menu-toggle"><button class="o-menu-toggle__btn" id="menu-toggle__btn" aria-controls="block-mainnavigation" aria-expanded="true">Menu</button></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="language-switcher-language-url has-no-translation" id="block-languageswitcher" role="navigation" aria-label="Language switcher">
|
||
|
||
|
||
<ul class="links">
|
||
<li class="is-active">
|
||
<a href="/research/clinical-trials/landmark-clinical-vision-and-eye-research/retinopathy-prematurity-research" class="language-link is-active" lang="en" data-drupal-link-system-path="node/3950" aria-current="page">English</a>
|
||
</li>
|
||
<li>
|
||
<a href="/espanol/node/3950" class="language-link is-active" lang="es" data-drupal-link-system-path="node/3950" aria-current="page"> Español</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</div>
|
||
<div class="search-global c-search--global" data-drupal-selector="search-global" id="block-globalsearchform" role="search">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<form action="/research/clinical-trials/landmark-clinical-vision-and-eye-research/retinopathy-prematurity-research" method="post" id="search-global" accept-charset="UTF-8">
|
||
<div class="c-form__inner">
|
||
<div class="js-form-item form-item js-form-type-textfield form-item-global-terms js-form-item-global-terms">
|
||
<label for="edit-global-terms">Search the site</label>
|
||
<input data-drupal-selector="edit-global-terms" type="text" id="edit-global-terms" name="global-terms" value="" size="30" maxlength="128" placeholder="Search the site" class="form-text" />
|
||
|
||
</div>
|
||
<input data-drupal-selector="form-ahcqniysncr8lxmla8tck1j8sicamy-7yjleoibblu" type="hidden" name="form_build_id" value="form-aHCQniYsNcR8lXMLa8tck1j8sIcaMY--7yjleoIBblU" />
|
||
<input data-drupal-selector="edit-search-global" type="hidden" name="form_id" value="search_global" />
|
||
<div data-drupal-selector="edit-global-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-global-actions"><input data-drupal-selector="edit-global-submit" type="submit" id="edit-global-submit" name="op" value="Search" class="button js-form-submit form-submit" />
|
||
</div>
|
||
|
||
</div>
|
||
</form>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="r-menu-primary">
|
||
<nav aria-label="Main navigation" id="block-mainnavigation" class="o-menu-main__outer">
|
||
|
||
<ul class="o-menu o-menu-main"> <li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/learn-about-eye-health" class="o-menu-main__link" data-drupal-link-system-path="node/39">Learn About Eye Health</a>
|
||
<ul class="o-menu o-menu-main__submenu"> <li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/healthy-vision" class="o-menu-main__link" data-drupal-link-system-path="node/788">Healthy Vision</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/eye-conditions-and-diseases" class="o-menu-main__link" data-drupal-link-system-path="learn-about-eye-health/eye-conditions-and-diseases">Eye Conditions and Diseases</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/eye-health-data-and-statistics" class="o-menu-main__link" data-drupal-link-system-path="node/825">Eye Health Data and Statistics</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/campaigns" class="o-menu-main__link" data-drupal-link-system-path="node/3859">Campaigns</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/vision-rehabilitation" class="o-menu-main__link" data-drupal-link-system-path="node/3865">Vision Rehabilitation</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/nei-for-kids" class="o-menu-main__link" data-drupal-link-system-path="node/162">NEI for Kids</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/outreach-resources" class="o-menu-main__link" data-drupal-link-system-path="node/125">Outreach Resources</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/grants-and-training" class="o-menu-main__link" data-drupal-link-system-path="node/143">Grants and Training</a>
|
||
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/grants-and-training/how-apply" class="o-menu-main__link" data-drupal-link-system-path="node/145">How to Apply</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/funding-opportunities" class="o-menu-main__link" data-drupal-link-system-path="node/144">Funding Opportunities</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/training-nei" class="o-menu-main__link" data-drupal-link-system-path="node/146">Training at NEI</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/funding-training-and-career-development" class="o-menu-main__link" data-drupal-link-system-path="node/152">Funding for Training and Career Development</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/policies-and-procedures" class="o-menu-main__link" data-drupal-link-system-path="node/149">Policies and Procedures</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/grants-and-training/Prior-Approval-Requests" class="o-menu-main__link" data-drupal-link-system-path="node/3918">Prior Approval Requests</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/resources-researchers" class="o-menu-main__link" data-drupal-link-system-path="node/150">Resources for Researchers</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/contact-grants-and-funding-staff" class="o-menu-main__link" data-drupal-link-system-path="node/151">Contact Grants and Funding Staff</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js o-menu-main__item--active-trail"> <a href="/research" class="o-menu-main__link" data-drupal-link-system-path="node/41">Research at NEI</a>
|
||
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/about/news-and-events/news" title="Research News" class="o-menu-main__link" data-drupal-link-system-path="about/news-and-events/news">Research News</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed o-menu-main__item--active-trail"> <a href="/research/clinical-trials" class="o-menu-main__link" data-drupal-link-system-path="node/132">Clinical Trials</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/research/research-labs-and-branches" class="o-menu-main__link" data-drupal-link-system-path="node/270">Research Labs and Branches</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/research/jobs-and-training-opportunities-nei" class="o-menu-main__link" data-drupal-link-system-path="node/564">Jobs and Training Opportunities at NEI</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/research/seminars" class="o-menu-main__link" data-drupal-link-system-path="node/4048">NEI Research Seminars</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/about" class="o-menu-main__link" data-drupal-link-system-path="node/275">About NEI</a>
|
||
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/about/strategic-planning" class="o-menu-main__link" data-drupal-link-system-path="node/2857">Strategic Planning</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/news-and-events" class="o-menu-main__link" data-drupal-link-system-path="node/131">News and Events</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/goals-and-accomplishments" class="o-menu-main__link" data-drupal-link-system-path="node/281">Goals and Accomplishments</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/nei-history" class="o-menu-main__link" data-drupal-link-system-path="node/282">NEI History</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/nei-leadership" class="o-menu-main__link" data-drupal-link-system-path="node/415">NEI Leadership</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/budget-and-congress" class="o-menu-main__link" data-drupal-link-system-path="node/395">Budget and Congress</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/advisory-committees" class="o-menu-main__link" data-drupal-link-system-path="node/285">Advisory Committees</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/outreach-resources/national-eye-health-education-program" title="National Eye Health Education Program" class="o-menu-main__link" data-drupal-link-system-path="node/265">National Eye Health Education Program</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/about/donate-nei" class="o-menu-main__link" data-drupal-link-system-path="node/286">Donate to NEI</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</nav>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="o-overlay" aria-hidden="true"></div>
|
||
|
||
<div class="r-breadcrumb">
|
||
|
||
<div id="block-nei-breadcrumbs">
|
||
|
||
|
||
|
||
|
||
|
||
<nav aria-label="Breadcrumb">
|
||
<ol class="c-breadcrumb">
|
||
<li>
|
||
<a href="/">Home</a>
|
||
</li>
|
||
<li>
|
||
<a href="/research">Research at NEI</a>
|
||
</li>
|
||
<li>
|
||
<a href="/research/clinical-trials">Clinical Trials</a>
|
||
</li>
|
||
<li>
|
||
<a href="/research/clinical-trials/landmark-clinical-vision-and-eye-research">Landmark Clinical Vision and Eye Research </a>
|
||
</li>
|
||
<li>
|
||
Retinopathy of Prematurity Research
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="r-page-header">
|
||
<div class="o-page-header">
|
||
|
||
<div id="block-nei-page-title">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<h1>
|
||
<span>Retinopathy of Prematurity Research </span>
|
||
</h1>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div id="block-jumpmenu-2">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-jump-menu">
|
||
<div class="c-jump-menu__intro">On this page:</div>
|
||
<a class="c-jump-menu__item" href="#section-id-20134">CRYO-ROP Trial</a>
|
||
<a class="c-jump-menu__item" href="#section-id-20137">STOP-ROP Trial</a>
|
||
<a class="c-jump-menu__item" href="#section-id-20140">Light-ROP Trial</a>
|
||
<a class="c-jump-menu__item" href="#section-id-20143">ETROP Trial</a>
|
||
<a class="c-jump-menu__item" href="#section-id-20146">e-ROP Trial</a>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="r-highlighted">
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
||
|
||
</div>
|
||
|
||
<div class="r-help">
|
||
|
||
</div>
|
||
<main id="main-content" class="r-main">
|
||
<div class="r-pre-content">
|
||
|
||
</div>
|
||
|
||
<div class="r-splitter">
|
||
<div class="r-content">
|
||
|
||
<div id="block-nei-content">
|
||
|
||
|
||
|
||
|
||
|
||
<article data-history-node-id="3950">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>Retinopathy of prematurity (ROP) is an eye disease that causes abnormal blood vessels to grow in a baby’s retina (light-sensitive layer of tissue at the back of the eye). It happens in babies who are premature (born early) — or who weigh less than 3 pounds at birth. Some babies with ROP develop retinal detachment, which can cause vision loss.</p>
|
||
|
||
<p>Clinical studies funded by NEI provide doctors, patients, and caregivers with the information they need to make informed health care decisions. And the results of these studies help to direct future research on preventing vision loss from ROP.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-link">
|
||
|
||
<a href="/learn-about-eye-health/eye-conditions-and-diseases/retinopathy-prematurity" class="c-link__link">Learn more about ROP</a>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-callout c-callout--wide c-callout--rounded" id="section-id-20240">
|
||
<div class="c-callout__content">
|
||
<h2 class="c-callout__heading">
|
||
|
||
|
||
|
||
|
||
Putting decades of eye health research into context
|
||
|
||
|
||
</h2>
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>Scientific research is cumulative, with new breakthroughs advancing the field and changing the landscape. And given NEI’s long history of research, results that were groundbreaking decades ago may be less directly relevant today. The studies showcased here represent landmarks in eye health research that laid the groundwork the treatments, diagnostic tools, and prevention options that exist today.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-link">
|
||
|
||
<a href="/about/news-and-events/news?topic=119&initiatives=All&research=All&source=All&date=All&language=All#views-exposed-form-news-page-page-1" class="c-link__link">Get the latest news about ROP research</a>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-section" id="section-id-20134">
|
||
<h2 class="c-section__heading">
|
||
|
||
|
||
|
||
|
||
CRYO-ROP Trial
|
||
|
||
|
||
</h2>
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>In 1986, researchers started the NEI-funded Cryotherapy for Retinopathy of Prematurity (CRYO-ROP, <a href="https://www.clinicaltrials.gov/study/NCT00000133?intr=Cryotherapy%20for%20Retinopathy%20of%20Prematurity%20(CRYO-ROP)&rank=1">NCT00000133</a>) Trial to measure the effectiveness of cryotherapy (freeze treatment) to prevent vision loss in babies with ROP. The trial recruited 279 babies with stage 3 ROP. Some babies with stage 3 ROP get better on their own, but some need treatment to prevent vision loss. The babies were randomly assigned to receive either cryotherapy or no treatment.</p><p>The CRYO-ROP Trial showed that cryotherapy could prevent vision loss in babies with ROP — without risking their ability to see in the future. It established cryotherapy as a safe and effective treatment for ROP at the time. The trial also highlighted the need for long-term follow-up, since researchers didn’t see the full picture of eye health outcomes until they collected findings 10 and 15 years after the trial began.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-link">
|
||
|
||
<a href="/about/news-and-events/news/freeze-treatment-reduces-blindness-premature-infants" class="c-link__link">Learn more about the CRYO-ROP Trial </a>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-section" id="section-id-20137">
|
||
<h2 class="c-section__heading">
|
||
|
||
|
||
|
||
|
||
STOP-ROP Trial
|
||
|
||
|
||
</h2>
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>In 1994, researchers started the NEI-funded Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (STOP-ROP, <a href="https://www.clinicaltrials.gov/study/NCT01203436?intr=Supplemental%20Therapeutic%20Oxygen%20for%20Prethreshold%20Retinopathy%20of%20Prematurity&rank=1">NCT01203436</a>) Trial to find out what effect, if any, supplemental oxygen therapy had on how ROP progressed in premature babies. The trial recruited 649 premature babies with moderate ROP and oxygen saturation below 94% and randomly assigned them to 1 of 2 groups:</p><ul><li>The treatment group got supplemental oxygen for at least 2 weeks</li><li>The control group didn’t get supplemental oxygen</li></ul><p>The STOP-ROP Trial showed that supplemental oxygen doesn’t cause moderate ROP to progress to severe ROP — so there’s no need to restrict use of oxygen therapy if babies with moderate ROP need it. This finding helped doctors and parents make more informed decisions about oxygen therapy for premature babies.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-link">
|
||
|
||
<a href="/about/news-and-events/news/oxygen-restrictions-can-be-eased-premature-infants-blinding-eye-disease" class="c-link__link">Learn more about the STOP-ROP Trial</a>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-section" id="section-id-20140">
|
||
<h2 class="c-section__heading">
|
||
|
||
|
||
|
||
|
||
Light-ROP Trial
|
||
|
||
|
||
</h2>
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>In 1995, researchers started the Effects of Light Reduction on Retinopathy of Prematurity (Light-ROP, <a href="https://www.clinicaltrials.gov/study/NCT00000156?intr=Light%20Reduction%20on%20Retinopathy%20of%20Prematurity&rank=1">NCT00000156</a>) Trial to measure the effects of reduced light exposure in babies with ROP. This NEI-funded trial recruited 409 premature babies at high risk for ROP and randomly assigned them to 1 of 2 groups:</p><ul><li>The treatment group wore goggles to reduce light exposure for 4 weeks after birth or until 31 weeks after conception</li><li>The control group was exposed to typical hospital nursery lighting</li></ul><p>The Light-ROP Trial was the first randomized controlled trial with a large enough sample size to provide strong evidence that light exposure doesn’t significantly raise ROP risk. Because of these results, researchers were able to move forward and look into other risk factors for ROP.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-link">
|
||
|
||
<a href="/about/news-and-events/news/light-reduction-does-not-affect-blinding-eye-disease-premature-infants" class="c-link__link">Learn more about the Light-ROP Trial </a>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-section" id="section-id-20143">
|
||
<h2 class="c-section__heading">
|
||
|
||
|
||
|
||
|
||
ETROP Trial
|
||
|
||
|
||
</h2>
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>In 2001, researchers started the NEI-funded Early Treatment for Retinopathy of Prematurity (ETROP, <a href="https://www.clinicaltrials.gov/study/NCT00027222?intr=%20Early%20Treatment%20for%20Retinopathy%20of%20Prematurity&rank=1">NCT00027222</a>) Trial to measure the effects of early treatment in premature babies at high risk of a severe type of ROP (Type 1). The trial recruited 401 premature babies with ROP who were at high risk of developing a severe form of the disease and then randomly assigned them to 1 of 2 groups:</p><ul><li>A group that received treatment for ROP earlier than the current standard of care</li><li>A group that received treatment based on the current standard of care</li></ul><p>The ETROP Trial monitored the babies for 6 years and showed that babies with severe ROP who were treated early had a lower risk of legal blindness than those who received treatment at the standard time. This trial also showed that babies with a less-severe type of ROP (Type 2) didn’t have better vision outcomes after early treatment — helping doctors make informed decisions about when to prescribe early treatment for babies with ROP.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-link">
|
||
|
||
<a href="/about/news-and-events/news/strategy-confirmed-help-doctors-determine-when-treat-retinopathy-prematurity" class="c-link__link">Learn more about the ETROP Trial</a>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-section" id="section-id-20146">
|
||
<h2 class="c-section__heading">
|
||
|
||
|
||
|
||
|
||
e-ROP Trial
|
||
|
||
|
||
</h2>
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>In 2011, researchers started the NEI-funded Telemedicine Approaches to Evaluating Acute-phase ROP (e-ROP, <a href="https://www.clinicaltrials.gov/study/NCT01264276?intr=%20Telemedicine%20Approaches%20to%20Evaluating%20Acute-phase%20ROP&rank=2">NCT01264276</a>) Trial to measure the effectiveness of telemedicine as a screening tool for babies at risk for ROP. The trial recruited 1,257 premature babies. It evaluated if staff at a remote image reading center could use photos of babies’ eyes to identify babies with suspected ROP as accurately as ophthalmologists examining babies in person.</p><p>The e-ROP Trial was the first large study to test if trained medical staff who aren’t doctors could use a telemedicine approach to screen for ROP. The trial’s telemedicine approach performed almost as well as onsite ophthalmologists at identifying ROP in premature babies. And the added convenience and expanded access to screening helped identify babies with advanced ROP earlier.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-link">
|
||
|
||
<a href="/about/news-and-events/news/telemedicine-catches-blinding-disease-premature-babies" class="c-link__link">Learn more about the e-ROP Trial </a>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-callout c-callout--wide c-callout--rounded" id="section-id-20148">
|
||
<figure class="c-callout__image">
|
||
<img src="https://www.nei.nih.gov/sites/default/files/styles/400px_square_crop/public/2019-03/icon_red_investigate_BG.png?itok=nLPxbSx4" alt="" />
|
||
</figure>
|
||
<div class="c-callout__content">
|
||
<h2 class="c-callout__heading">
|
||
|
||
|
||
|
||
|
||
Learn more
|
||
|
||
|
||
</h2>
|
||
|
||
|
||
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<ul><li><a href="/about/news-and-events/news?topic=119">Get the latest news on NEI-supported ROP research</a></li><li><a href="/research/clinical-trials/learn-about-clinical-trials">Learn about clinical trials</a></li><li><a href="/grants-and-training/funding-opportunities/current-funding-opportunities">Explore current NEI funding opportunities</a></li><li><a href="/grants-and-training/funding-opportunities/programs-and-research-priorities">Get an overview of NEI’s programs and research priorities</a></li></ul>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</article>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<p class="views-element-container c-last-updated" id="block-views-block-nei-last-updated-block-1"><strong>Last updated:</strong> December 16, 2024</p>
|
||
|
||
|
||
</div>
|
||
<aside class="r-sidebar" role="complementary">
|
||
|
||
<div class="views-element-container" id="block-views-block-nei-sidebar-block-1">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="js-view-dom-id-04ae369b7c7f57ad99d97a2dcb2da1872b4ba7dd842d637423df3605142ed593 nei-sidebar">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="views-row">
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</aside>
|
||
</div>
|
||
</main>
|
||
|
||
<div class="r-footer">
|
||
<footer class="o-footer" role="contentinfo">
|
||
|
||
<div id="block-footer-2">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-footer__row">
|
||
<div class="o-footer__group o-footer__group--logo"><a class="o-logo__link" href="/" rel="home" title="Home"><span class="o-logo__text">National Eye Institute</span></a>
|
||
<ul class="o-menu-social">
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--facebook outlink-ignore" href="https://www.facebook.com/NationalEyeInstitute">Facebook</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--twitter outlink-ignore" href="https://twitter.com/NatEyeInstitute">Twitter</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--linkedin outlink-ignore" href="https://www.linkedin.com/company/national-eye-institute-nei">LinkedIn</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--youtube outlink-ignore" href="https://www.youtube.com/user/neinih">YouTube</a></li>
|
||
</ul>
|
||
|
||
<p> </p>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--contact">
|
||
<h2 class="o-footer__title">Contact NEI</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/contact-us/">Contact Us</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/about-nih/visitor-information">Visit NIH</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://list.nih.gov/cgi-bin/wa.exe?SUBED1=insidenei&A=1">Get Email Updates from NEI</a></li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--policies">
|
||
<h2 class="o-footer__title">Policies</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/accessibility-information">Accessibility</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/nondiscrimination-notice-language-assistance-services">Information in Other Languages</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/nei-website-privacy-policy">Privacy</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/freedom-information-act">Freedom of Information Act (FOIA)</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/disclaimers">Disclaimers</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/web-policies ">Web Policies</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html ">Vulnerability Disclosure</a></li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--employees">
|
||
<h2 class="o-footer__title">For NEI Employees</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov">Intranet</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov/hr/Pages/emergency.aspx">Emergency Information</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://ned.nih.gov/search/search.aspx">NIH Staff Directory</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="o-footer__row">
|
||
<div class="o-footer__full o-footer__full--parent">
|
||
<ul class="o-menu-footer o-menu-footer--swing">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/">NIH.gov</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://hhs.gov/">HHS.gov</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://usa.gov/">USA.gov</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</footer>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-lb-wrapper" id="lb-wrapper" aria-hidden="true">
|
||
<div class="c-lb-overlay" tabindex="-1"></div>
|
||
<div role="dialog" class="c-lb" id="lb">
|
||
<div class="c-lb-header">
|
||
<button class="c-lb-close-btn"><span class="c-lb-close-btn-text">Close</span><span class="c-lb-close-btn-text times" aria-hidden="true">×</span></button>
|
||
</div>
|
||
<figure class="c-lb-figure">
|
||
<figcaption class="c-lb-caption"></figcaption>
|
||
</figure>
|
||
</div>
|
||
</div>
|
||
|
||
<script src="/sites/default/files/js/js_agazM-qm5cOcplNZo9kNIWFtUrwt0V1xgAKtLyM44Us.js?scope=footer&delta=0&language=en&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
||
<script src="/themes/custom/nei/js/scripts.js?sraguf"></script>
|
||
|
||
</body>
|
||
</html>
|