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NEI Scientists publish recipe for making blood vessel cells from patient stem cells
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<span>NEI Scientists publish recipe for making blood vessel cells from patient stem cells</span>
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May 15, 2023
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<p>Researchers at NIH’s National Eye Institute have published a detailed protocol for making three cell types that are key components to form blood vessels and capillaries. The technique enables researchers to make tissues for study and potentially for future treatments.</p><p>“This protocol generates vascular endothelial cells, pericytes, and fibroblasts from human induced pluripotent stem cells, called iPSCs,” said Tea Soon Park, Ph.D., NEI Ocular and Stem Cell Translational Research Section, and lead author of the protocol.</p>
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<p>Tea Soon Park and Rishabh Hirday, NEI Ocular and Stem Cell Translational Research Section, explain how to produce blood vessel cells from patient stem cells.</p>
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<p>IPSCs are made in a lab, starting with skin or blood cells. They can then be modified to create nearly any other cell type of the body.</p><p>“Since all three cell types in this protocol are major parts of vascular structure, it will be a useful tool to study a variety of diseases including eye disease,” said Park.</p><p>The five-step protocol, from iPSCs to fibroblasts, takes about four weeks. It includes seeding of iPSCs, seven days of monolayer differentiation, and cell separation based on CD31 expression. CD31 is a cell-surface protein unique to endothelial cells. At the end of step 3, endothelial and pericyte populations are separated. Fibroblasts can then be further differentiated from pericytes.</p><p>Park and colleagues are now working on a method to combine the three patient-derived cell types using bioprinting, which distributes and orients cells in a 3D space resembling the tissue microenvironment.</p><p>Reference:<br>Park TS, Hirday R, Ali A, et al. Protocol to generate endothelial cells, pericytes, and fibroblasts in one differentiation round from human-induced pluripotent stem cells. STAR Protoc. May 6 2023;4(2):102292. <a href="https://pubmed.ncbi.nlm.nih.gov/37149860/">doi:10.1016/j.xpro.2023.102292</a></p><p><a href="https://www.nei.nih.gov/about/news-and-events/news?topic=All&initiatives=170&research=All&source=All&date=All&language=All#views-exposed-form-news-page-page-1">More research stories about the NEI Ocular and Stem Cell Translational Research Section</a>.</p><p>###</p><p><br>This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process— each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research. To learn more about basic research, visit <a href="https://www.nih.gov/news-events/basic-research-digital-media-kit">https://www.nih.gov/news-events/basic-research-digital-media-kit</a>.</p><p>NEI leads the federal government’s efforts to eliminate vision loss and improve quality of life through vision research…driving innovation, fostering collaboration, expanding the vision workforce, and educating the public and key stakeholders. NEI supports basic and clinical science programs to develop sight-saving treatments and to broaden opportunities for people with vision impairment. For more information, visit <a href="https://www.nei.nih.gov/">https://www.nei.nih.gov</a>.</p><p>About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit https://www.nih.gov/.</p><p>NIH…Turning Discovery Into Health®</p>
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