621 lines
29 KiB
Text
621 lines
29 KiB
Text
|
|
<!DOCTYPE html>
|
|
<html lang="en" dir="ltr">
|
|
<head>
|
|
<meta charset="utf-8" />
|
|
<meta name="description" content="Study from University of Alabama at Birmingham suggests that a leaky small intestine that weakens the barrier between gut bacteria and the blood system may drive diabetic retinopathy." />
|
|
<meta name="keywords" content="Diabetic Eye Disease" />
|
|
<meta name="google" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw,lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
|
<meta name="google-site-verification" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw" />
|
|
<meta name="google-site-verification" content="lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
|
<meta name="google-site-verification" content="UDfyeEAWNX_rJUHwog9j1kziEnByGwhkSJGLJclUWDA" />
|
|
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
|
<script type="application/ld+json">{
|
|
"@context": "https://schema.org",
|
|
"@graph": [
|
|
{
|
|
"@type": "NewsArticle",
|
|
"@id": "https://www.nei.nih.gov/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness",
|
|
"name": "Type 1 diabetes: Maintaining the enzyme ACE2 in the gut prevents diabetic blindness",
|
|
"headline": "Type 1 diabetes: Maintaining the enzyme ACE2 in the gut prevents diabetic blindness",
|
|
"image": {
|
|
"@type": "ImageObject",
|
|
"representativeOfPage": "False",
|
|
"url": "https://www.nei.nih.gov/sites/default/files/styles/medium/public/news/abnormal_blood-.jpg?itok=lbW1UVtM",
|
|
"width": "263",
|
|
"height": "158"
|
|
},
|
|
"datePublished": "2023-01-13T15:32:53-0500",
|
|
"dateModified": "2025-01-23T14:02:04-0500",
|
|
"author": {
|
|
"@type": "GovernmentOrganization",
|
|
"@id": "https://www.nei.nih.gov/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness",
|
|
"name": "National Eye Institute",
|
|
"url": "https://www.nei.nih.gov"
|
|
},
|
|
"publisher": {
|
|
"@type": "GovernmentOrganization",
|
|
"@id": "https://www.nei.nih.gov/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness",
|
|
"name": "National Eye Institute",
|
|
"url": "https://www.nei.nih.gov"
|
|
}
|
|
},
|
|
{
|
|
"@type": "WebPage",
|
|
"@id": "https://www.nei.nih.gov/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness",
|
|
"breadcrumb": {
|
|
"@type": "BreadcrumbList",
|
|
"itemListElement": [
|
|
{
|
|
"@type": "ListItem",
|
|
"position": 1,
|
|
"name": "Home",
|
|
"item": "https://www.nei.nih.gov/"
|
|
},
|
|
{
|
|
"@type": "ListItem",
|
|
"position": 2,
|
|
"name": "About NEI",
|
|
"item": "https://www.nei.nih.gov/about"
|
|
},
|
|
{
|
|
"@type": "ListItem",
|
|
"position": 3,
|
|
"name": "News and Events",
|
|
"item": "https://www.nei.nih.gov/about/news-and-events"
|
|
},
|
|
{
|
|
"@type": "ListItem",
|
|
"position": 4,
|
|
"name": "NEI Research News",
|
|
"item": "https://www.nei.nih.gov/about/news-and-events/news"
|
|
},
|
|
{
|
|
"@type": "ListItem",
|
|
"position": 5,
|
|
"name": "Type 1 diabetes: Maintaining the enzyme ACE2 in the gut prevents diabetic blindness",
|
|
"item": "https://www.nei.nih.gov/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness"
|
|
}
|
|
]
|
|
},
|
|
"author": {
|
|
"@type": "GovernmentOrganization",
|
|
"@id": "https://www.nei.nih.gov",
|
|
"name": "National Eye Institute",
|
|
"url": "https://www.nei.nih.gov"
|
|
},
|
|
"publisher": {
|
|
"@type": "GovernmentOrganization",
|
|
"@id": "https://www.nei.nih.gov",
|
|
"name": "National Eye Institute",
|
|
"url": "https://www.nei.nih.gov"
|
|
}
|
|
}
|
|
]
|
|
}</script>
|
|
<link rel="icon" type="image/png" href="/themes/custom/nei/images/favicon.png" />
|
|
<link rel="apple-touch-icon" href="/themes/custom/nei/images/apple-touch-icon.png" />
|
|
<meta name="last-updated" content="Jan 23, 2025, 2:02:04 PM" />
|
|
<link rel="icon" href="/themes/custom/nei/favicon.ico" type="image/vnd.microsoft.icon" />
|
|
<link rel="alternate" hreflang="en" href="https://www.nei.nih.gov/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness" />
|
|
<link rel="canonical" href="https://www.nei.nih.gov/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness" />
|
|
<link rel="shortlink" href="https://www.nei.nih.gov/node/3871" />
|
|
|
|
<title>Type 1 diabetes: Maintaining the enzyme ACE2 in the gut prevents diabetic blindness | National Eye Institute</title>
|
|
<link rel="preload" href="/themes/custom/nei/fonts/Aleo-Bold.woff2" as="font" type="font/woff2" crossorigin>
|
|
<link rel="preload" href="/themes/custom/nei/fonts/Lato-Regular.woff2" as="font" type="font/woff2" crossorigin>
|
|
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_PGSk_7b88hq2qr_--_38MLvoj1ffr9jv3JhnNJTnKUM.css?delta=0&language=en&theme=nei&include=eJw1ytEKgCAMRuEXsnwk-dMxrOliTqi3j4iuDnycfFCprpbyHK4tDb-FRvwSshrFYvOErNhxBUHnCaYEcbJ_61Qji26Q5ZXa-QH_YCJ9" />
|
|
<link rel="stylesheet" media="all" href="/themes/custom/nei/css/style.css?sraguf" />
|
|
|
|
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/3871","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxdjFsOwjAMBC8U6iNFbmKZgPNQ7BTK6SmgCsrPrndkTbhSTFa7D0OtZq-2Cil8yoWOj5WYYT8c18pC3pCBt_jfE17wfoTZCRYeyORRjPruLmhpIS-b2EvFmArD73CFErDUGeWkoadmekCb5fXVsCN3bGeF2EdDmb5kGqWNWZKeKTpd1SjDjEpuSXRTeOeUaxxCT9WYZ50","theme":"nei","theme_token":null},"ajaxTrustedUrl":{"form_action_p_pvdeGsVG5zNF_XLGPTvYSKCf43t8qZYSwcfZl2uzM":true},"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"google\nnonGooglePixels\nnonGoogleScripts\nnonGoogleIframes","blocklist_classes":"customScripts\ncustomPixels","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-TLVNS7W"]},"user":{"uid":0,"permissionsHash":"c48594e108b5c1c2bea409821b71477d5bc2724c8cae6d31f1d985af0daab85c"}}</script>
|
|
<script src="/sites/default/files/js/js_WgzMsgqb-MiW-Z2aLffGQHepZwX2hWrEHSrb46WqZrk.js?scope=header&delta=0&language=en&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
|
<script src="https://script.crazyegg.com/pages/scripts/0117/6571.js" async></script>
|
|
<script src="/modules/contrib/google_tag/js/gtag.js?sraguf"></script>
|
|
<script src="/modules/contrib/google_tag/js/gtm.js?sraguf"></script>
|
|
|
|
</head>
|
|
<body class="t-news_item t-node__3871 path-about-news-and-events-news-type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness">
|
|
<a href="#main-content" class="u-skip-link">
|
|
Skip to content
|
|
</a>
|
|
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-TLVNS7W"
|
|
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
|
|
|
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
|
|
|
<div id="u-page-outer" class="u-outer">
|
|
<div class="views-element-container site-notice-block" id="block-views-block-site-notices-block-1">
|
|
|
|
|
|
|
|
|
|
|
|
<div>
|
|
<div class="js-view-dom-id-bca3892fe522a94248c74087cbf8646ffbc018befc8d0e64978ba8c06dc01631 site-notices">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
<img src="/themes/custom/nei/images/NEI-logo-tagline.svg" alt="" width="200" height="48" class="u-print-only">
|
|
<div class="r-global-header">
|
|
<div id="r-header-outer" class="r-header">
|
|
|
|
<div class="r-header-inner">
|
|
|
|
<div id="block-nei-branding" class="o-block--logo" role="banner">
|
|
|
|
|
|
|
|
|
|
|
|
<div class="o-logo">
|
|
<a href="/" class="o-logo__link" title="Home" rel="home"><span class="o-logo__text">National Eye Institute</span> <span class="o-logo__tagline">Research Today… Vision Tomorrow</span></a>
|
|
</div>
|
|
|
|
|
|
</div>
|
|
|
|
<div id="block-neimenubutton-2">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<div class="o-menu-toggle"><button class="o-menu-toggle__btn" id="menu-toggle__btn" aria-controls="block-mainnavigation" aria-expanded="true">Menu</button></div>
|
|
|
|
|
|
|
|
|
|
</div>
|
|
<div class="language-switcher-language-url has-no-translation" id="block-languageswitcher" role="navigation" aria-label="Language switcher">
|
|
|
|
|
|
<ul class="links">
|
|
<li class="is-active">
|
|
<a href="/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness" class="language-link is-active" lang="en" data-drupal-link-system-path="node/3871" aria-current="page">English</a>
|
|
</li>
|
|
<li>
|
|
<a href="/espanol/node/3871" class="language-link is-active" lang="es" data-drupal-link-system-path="node/3871" aria-current="page"> Español</a>
|
|
</li>
|
|
</ul>
|
|
|
|
|
|
</div>
|
|
<div class="search-global c-search--global" data-drupal-selector="search-global" id="block-globalsearchform" role="search">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<form action="/about/news-and-events/news/type-1-diabetes-maintaining-enzyme-ace2-gut-prevents-diabetic-blindness" method="post" id="search-global" accept-charset="UTF-8">
|
|
<div class="c-form__inner">
|
|
<div class="js-form-item form-item js-form-type-textfield form-item-global-terms js-form-item-global-terms">
|
|
<label for="edit-global-terms">Search the site</label>
|
|
<input data-drupal-selector="edit-global-terms" type="text" id="edit-global-terms" name="global-terms" value="" size="30" maxlength="128" placeholder="Search the site" class="form-text" />
|
|
|
|
</div>
|
|
<input data-drupal-selector="form-c8mbgisn6ymxy8mugmzl0gipzi7rng9nmhlwg6yvalm" type="hidden" name="form_build_id" value="form-c8MBGiSN6ymXY8mUgmZL0giPZi7RNG9NMHlwG6yvalM" />
|
|
<input data-drupal-selector="edit-search-global" type="hidden" name="form_id" value="search_global" />
|
|
<div data-drupal-selector="edit-global-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-global-actions"><input data-drupal-selector="edit-global-submit" type="submit" id="edit-global-submit" name="op" value="Search" class="button js-form-submit form-submit" />
|
|
</div>
|
|
|
|
</div>
|
|
</form>
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
|
|
</div>
|
|
|
|
</div>
|
|
|
|
<div class="r-menu-primary">
|
|
<nav aria-label="Main navigation" id="block-mainnavigation" class="o-menu-main__outer">
|
|
|
|
<ul class="o-menu o-menu-main"> <li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/learn-about-eye-health" class="o-menu-main__link" data-drupal-link-system-path="node/39">Learn About Eye Health</a>
|
|
<ul class="o-menu o-menu-main__submenu"> <li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/healthy-vision" class="o-menu-main__link" data-drupal-link-system-path="node/788">Healthy Vision</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/eye-conditions-and-diseases" class="o-menu-main__link" data-drupal-link-system-path="learn-about-eye-health/eye-conditions-and-diseases">Eye Conditions and Diseases</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/eye-health-data-and-statistics" class="o-menu-main__link" data-drupal-link-system-path="node/825">Eye Health Data and Statistics</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/campaigns" class="o-menu-main__link" data-drupal-link-system-path="node/3859">Campaigns</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/vision-rehabilitation" class="o-menu-main__link" data-drupal-link-system-path="node/3865">Vision Rehabilitation</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/nei-for-kids" class="o-menu-main__link" data-drupal-link-system-path="node/162">NEI for Kids</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/outreach-resources" class="o-menu-main__link" data-drupal-link-system-path="node/125">Outreach Resources</a>
|
|
</li>
|
|
</ul>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/grants-and-training" class="o-menu-main__link" data-drupal-link-system-path="node/143">Grants and Training</a>
|
|
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/grants-and-training/how-apply" class="o-menu-main__link" data-drupal-link-system-path="node/145">How to Apply</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/funding-opportunities" class="o-menu-main__link" data-drupal-link-system-path="node/144">Funding Opportunities</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/training-nei" class="o-menu-main__link" data-drupal-link-system-path="node/146">Training at NEI</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/funding-training-and-career-development" class="o-menu-main__link" data-drupal-link-system-path="node/152">Funding for Training and Career Development</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/policies-and-procedures" class="o-menu-main__link" data-drupal-link-system-path="node/149">Policies and Procedures</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/grants-and-training/Prior-Approval-Requests" class="o-menu-main__link" data-drupal-link-system-path="node/3918">Prior Approval Requests</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/resources-researchers" class="o-menu-main__link" data-drupal-link-system-path="node/150">Resources for Researchers</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/contact-grants-and-funding-staff" class="o-menu-main__link" data-drupal-link-system-path="node/151">Contact Grants and Funding Staff</a>
|
|
</li>
|
|
</ul>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/research" class="o-menu-main__link" data-drupal-link-system-path="node/41">Research at NEI</a>
|
|
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/about/news-and-events/news" title="Research News" class="o-menu-main__link" data-drupal-link-system-path="about/news-and-events/news">Research News</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/research/clinical-trials" class="o-menu-main__link" data-drupal-link-system-path="node/132">Clinical Trials</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/research/research-labs-and-branches" class="o-menu-main__link" data-drupal-link-system-path="node/270">Research Labs and Branches</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/research/jobs-and-training-opportunities-nei" class="o-menu-main__link" data-drupal-link-system-path="node/564">Jobs and Training Opportunities at NEI</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/research/seminars" class="o-menu-main__link" data-drupal-link-system-path="node/4048">NEI Research Seminars</a>
|
|
</li>
|
|
</ul>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/about" class="o-menu-main__link" data-drupal-link-system-path="node/275">About NEI</a>
|
|
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/about/strategic-planning" class="o-menu-main__link" data-drupal-link-system-path="node/2857">Strategic Planning</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/news-and-events" class="o-menu-main__link" data-drupal-link-system-path="node/131">News and Events</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/goals-and-accomplishments" class="o-menu-main__link" data-drupal-link-system-path="node/281">Goals and Accomplishments</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/nei-history" class="o-menu-main__link" data-drupal-link-system-path="node/282">NEI History</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/nei-leadership" class="o-menu-main__link" data-drupal-link-system-path="node/415">NEI Leadership</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/budget-and-congress" class="o-menu-main__link" data-drupal-link-system-path="node/395">Budget and Congress</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/advisory-committees" class="o-menu-main__link" data-drupal-link-system-path="node/285">Advisory Committees</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/outreach-resources/national-eye-health-education-program" title="National Eye Health Education Program" class="o-menu-main__link" data-drupal-link-system-path="node/265">National Eye Health Education Program</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/about/donate-nei" class="o-menu-main__link" data-drupal-link-system-path="node/286">Donate to NEI</a>
|
|
</li>
|
|
</ul>
|
|
</li>
|
|
</ul>
|
|
|
|
|
|
</nav>
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
<div class="o-overlay" aria-hidden="true"></div>
|
|
|
|
<div class="r-breadcrumb">
|
|
|
|
<div id="block-nei-breadcrumbs">
|
|
|
|
|
|
|
|
|
|
|
|
<nav aria-label="Breadcrumb">
|
|
<ol class="c-breadcrumb">
|
|
<li>
|
|
<a href="/">Home</a>
|
|
</li>
|
|
<li>
|
|
<a href="/about">About NEI</a>
|
|
</li>
|
|
<li>
|
|
<a href="/about/news-and-events">News and Events</a>
|
|
</li>
|
|
<li>
|
|
<a href="/about/news-and-events/news">NEI Research News</a>
|
|
</li>
|
|
<li>
|
|
Type 1 diabetes: Maintaining the enzyme ACE2 in the gut prevents diabetic blindness
|
|
</li>
|
|
</ol>
|
|
</nav>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<div class="r-page-header">
|
|
<div class="o-page-header">
|
|
|
|
<div id="block-nei-page-title">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<h1>
|
|
<span>Type 1 diabetes: Maintaining the enzyme ACE2 in the gut prevents diabetic blindness</span>
|
|
</h1>
|
|
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
<div class="r-highlighted">
|
|
<div data-drupal-messages-fallback class="hidden"></div>
|
|
|
|
|
|
</div>
|
|
|
|
<div class="r-help">
|
|
|
|
</div>
|
|
<main id="main-content" class="r-main">
|
|
<div class="r-pre-content">
|
|
|
|
</div>
|
|
|
|
<div class="r-splitter">
|
|
<div class="r-content">
|
|
|
|
<div id="block-nei-content">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<article data-history-node-id="3871">
|
|
|
|
|
|
|
|
<div>
|
|
|
|
<div class="c-item__date">
|
|
January 13, 2023
|
|
</div>
|
|
|
|
|
|
|
|
|
|
<div class="c-item__tag c-item__tag--topic">
|
|
<a href="/about/news-and-events/news?topic=13" hreflang="en">Diabetic Eye Disease</a>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
|
|
<div class="c-item__tag c-item__tag--research-type">
|
|
<a href="/about/news-and-events/news?research=35" hreflang="en">Translational Research</a>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
|
|
<div class="c-item__tag c-item__tag--source">
|
|
<a href="/about/news-and-events/news?source=29" hreflang="en">Grantee</a>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
|
|
<div class="o-news__content">
|
|
<div class="c-text">
|
|
|
|
|
|
|
|
|
|
<p>The leading cause of blindness in American adults is diabetic retinopathy, progressive damage to blood vessels in the light-sensitive tissue at the back of the eye. Yet the source of this damage appears to lie in the belly — mainly a leaky small intestine that weakens the barrier between gut bacteria and the blood system, according to a study from the University of Alabama at Birmingham.</p><p>Blood from human subjects with Type 1 diabetes and a mouse model of Type 1 diabetes were used to explore mechanisms underlying diabetic retinopathy. The results show a way to possibly prevent, or even reverse, the eye damage.</p><p>Using the Akita mouse-Type 1 diabetes model, researchers gave the ACE2-producing Lactobacillus paracasei to the mice orally beginning at the onset of diabetes. This probiotic treatment prevented the loss of gut epithelial ACE2 typically seen in Akita mice, and importantly, it prevented intestinal epithelial and endothelial barrier damage. It also reduced the high blood sugar levels known as hyperglycemia.</p><p>The researchers also found evidence for several mechanisms that contributed to the ACE2-reduced gut barrier damage and ACE2-lowering of blood sugar.</p>
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<div class="c-link">
|
|
|
|
<a href="https://www.uab.edu/news/research/item/13345-type-1-diabetes-maintaining-the-enzyme-ace2-in-the-gut-prevents-diabetic-blindness" class="c-link__link">Read more at UAB News</a>
|
|
|
|
</div>
|
|
|
|
</div>
|
|
|
|
|
|
</div>
|
|
|
|
</article>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
</div>
|
|
<aside class="r-sidebar" role="complementary">
|
|
|
|
<div class="views-element-container" id="block-views-block-nei-sidebar-block-1">
|
|
|
|
|
|
|
|
|
|
|
|
<div>
|
|
<div class="js-view-dom-id-8e330863a4dc3704b97df8365cfb5e5060ddf6be9bedb685530b2ef9bd64d262 nei-sidebar">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
</aside>
|
|
</div>
|
|
</main>
|
|
|
|
<div class="r-footer">
|
|
<footer class="o-footer" role="contentinfo">
|
|
|
|
<div id="block-footer-2">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<div class="o-footer__row">
|
|
<div class="o-footer__group o-footer__group--logo"><a class="o-logo__link" href="/" rel="home" title="Home"><span class="o-logo__text">National Eye Institute</span></a>
|
|
<ul class="o-menu-social">
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--facebook outlink-ignore" href="https://www.facebook.com/NationalEyeInstitute">Facebook</a></li>
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--twitter outlink-ignore" href="https://twitter.com/NatEyeInstitute">Twitter</a></li>
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--linkedin outlink-ignore" href="https://www.linkedin.com/company/national-eye-institute-nei">LinkedIn</a></li>
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--youtube outlink-ignore" href="https://www.youtube.com/user/neinih">YouTube</a></li>
|
|
</ul>
|
|
|
|
<p> </p>
|
|
</div>
|
|
|
|
<div class="o-footer__group o-footer__group--contact">
|
|
<h2 class="o-footer__title">Contact NEI</h2>
|
|
|
|
<ul class="o-menu-footer">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/contact-us/">Contact Us</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/about-nih/visitor-information">Visit NIH</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://list.nih.gov/cgi-bin/wa.exe?SUBED1=insidenei&A=1">Get Email Updates from NEI</a></li>
|
|
</ul>
|
|
</div>
|
|
|
|
<div class="o-footer__group o-footer__group--policies">
|
|
<h2 class="o-footer__title">Policies</h2>
|
|
|
|
<ul class="o-menu-footer">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/accessibility-information">Accessibility</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/nondiscrimination-notice-language-assistance-services">Information in Other Languages</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/nei-website-privacy-policy">Privacy</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/freedom-information-act">Freedom of Information Act (FOIA)</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/disclaimers">Disclaimers</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/web-policies ">Web Policies</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html ">Vulnerability Disclosure</a></li>
|
|
</ul>
|
|
</div>
|
|
|
|
<div class="o-footer__group o-footer__group--employees">
|
|
<h2 class="o-footer__title">For NEI Employees</h2>
|
|
|
|
<ul class="o-menu-footer">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov">Intranet</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov/hr/Pages/emergency.aspx">Emergency Information</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://ned.nih.gov/search/search.aspx">NIH Staff Directory</a></li>
|
|
</ul>
|
|
</div>
|
|
</div>
|
|
|
|
<div class="o-footer__row">
|
|
<div class="o-footer__full o-footer__full--parent">
|
|
<ul class="o-menu-footer o-menu-footer--swing">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/">NIH.gov</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://hhs.gov/">HHS.gov</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://usa.gov/">USA.gov</a></li>
|
|
</ul>
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
</footer>
|
|
</div>
|
|
|
|
</div>
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<div class="c-lb-wrapper" id="lb-wrapper" aria-hidden="true">
|
|
<div class="c-lb-overlay" tabindex="-1"></div>
|
|
<div role="dialog" class="c-lb" id="lb">
|
|
<div class="c-lb-header">
|
|
<button class="c-lb-close-btn"><span class="c-lb-close-btn-text">Close</span><span class="c-lb-close-btn-text times" aria-hidden="true">×</span></button>
|
|
</div>
|
|
<figure class="c-lb-figure">
|
|
<figcaption class="c-lb-caption"></figcaption>
|
|
</figure>
|
|
</div>
|
|
</div>
|
|
|
|
<script src="/sites/default/files/js/js_agazM-qm5cOcplNZo9kNIWFtUrwt0V1xgAKtLyM44Us.js?scope=footer&delta=0&language=en&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
|
<script src="/themes/custom/nei/js/scripts.js?sraguf"></script>
|
|
|
|
</body>
|
|
</html>
|