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July 28, 2022
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<p>Collaborators from the University of Pennsylvania, University of Wisconsin, Children’s Hospital of Philadelphia, and NEI's Intramural Research Program, successfully implanted human-derived photoreceptor precursor cells into the retinas of dogs. Photoreceptors are light-sensing cells in the retina that enable vision. Dozens of rare eye conditions cause the loss of photoreceptor cells - common ones, too, including age-related macular degeneration. Photoreceptors communicate with other retinal neurons that in turn signal the brain. The project was funded by NEI's <a href="/about/goals-and-accomplishments/nei-research-initiatives/audacious-goals-initiative">Audacious Goals Initiative</a>, an effort to restore vision through regeneration of the retina.</p>
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<p>Following a transplantation procedure, human photoreceptor precursor cells, labeled red, migrated and integrated into a degenerated canine retina. The green label is a synaptic maker, suggesting the transplanted cells began forming a connection with second-order neurons in the retina. Credit: William Beltran, U. Penn.</p>
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<p>“In this study, we wanted to know if we could, one, improve the surgical delivery of these cells to the subretinal space; two, image the cells in vivo; three, improve their survival; and four, see them migrate to the layer of the retina where they should be and start integrating,” said William Beltran, a professor of ophthalmology at the University of Pennsylvania School of Veterinary Medicine and senior author on the study. “The answer to all those questions was yes.”</p><p><a href="https://penntoday.upenn.edu/news/progress-toward-stem-cell-based-therapy-blindness">University of Pennsylvania news story</a></p>
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