613 lines
35 KiB
Text
613 lines
35 KiB
Text
|
||
<!DOCTYPE html>
|
||
<html lang="en" dir="ltr">
|
||
<head>
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="Researchers have stopped patient enrollment and treatment in a study designed to evaluate the safety and effectiveness of a new drug to treat a blinding eye infection common in people with AIDS." />
|
||
<meta name="keywords" content="Infectious Disease" />
|
||
<meta name="google" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw,lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
||
<meta name="google-site-verification" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw" />
|
||
<meta name="google-site-verification" content="lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
||
<meta name="google-site-verification" content="UDfyeEAWNX_rJUHwog9j1kziEnByGwhkSJGLJclUWDA" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<script type="application/ld+json">{
|
||
"@context": "https://schema.org",
|
||
"@graph": [
|
||
{
|
||
"@type": "NewsArticle",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease",
|
||
"name": "NIH-Sponsored Study Stopped: New Drug Does Not Control AIDS-Related Eye Disease",
|
||
"headline": "NIH-Sponsored Study Stopped: New Drug Does Not Control AIDS-Related Eye Disease",
|
||
"image": {
|
||
"@type": "ImageObject",
|
||
"representativeOfPage": "False",
|
||
"url": "https://www.nei.nih.gov/sites/default/files/styles/medium/public/2019-04/NEI_Logo.jpg?itok=QPXvn3Ph",
|
||
"width": "730",
|
||
"height": "670"
|
||
},
|
||
"datePublished": "1996-08-15T16:06:47-0400",
|
||
"dateModified": "2025-01-29T15:21:24-0500",
|
||
"author": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
},
|
||
"publisher": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
}
|
||
},
|
||
{
|
||
"@type": "WebPage",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease",
|
||
"breadcrumb": {
|
||
"@type": "BreadcrumbList",
|
||
"itemListElement": [
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 1,
|
||
"name": "Home",
|
||
"item": "https://www.nei.nih.gov/"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 2,
|
||
"name": "About NEI",
|
||
"item": "https://www.nei.nih.gov/about"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 3,
|
||
"name": "News and Events",
|
||
"item": "https://www.nei.nih.gov/about/news-and-events"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 4,
|
||
"name": "NEI Research News",
|
||
"item": "https://www.nei.nih.gov/about/news-and-events/news"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 5,
|
||
"name": "NIH-Sponsored Study Stopped: New Drug Does Not Control AIDS-Related Eye Disease",
|
||
"item": "https://www.nei.nih.gov/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease"
|
||
}
|
||
]
|
||
},
|
||
"author": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
},
|
||
"publisher": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
}
|
||
}
|
||
]
|
||
}</script>
|
||
<link rel="icon" type="image/png" href="/themes/custom/nei/images/favicon.png" />
|
||
<link rel="apple-touch-icon" href="/themes/custom/nei/images/apple-touch-icon.png" />
|
||
<meta name="last-updated" content="Jan 29, 2025, 3:21:24 PM" />
|
||
<link rel="icon" href="/themes/custom/nei/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<link rel="alternate" hreflang="en" href="https://www.nei.nih.gov/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease" />
|
||
<link rel="canonical" href="https://www.nei.nih.gov/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease" />
|
||
<link rel="shortlink" href="https://www.nei.nih.gov/node/3629" />
|
||
|
||
<title>NIH-Sponsored Study Stopped: New Drug Does Not Control AIDS-Related Eye Disease | National Eye Institute</title>
|
||
<link rel="preload" href="/themes/custom/nei/fonts/Aleo-Bold.woff2" as="font" type="font/woff2" crossorigin>
|
||
<link rel="preload" href="/themes/custom/nei/fonts/Lato-Regular.woff2" as="font" type="font/woff2" crossorigin>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_PGSk_7b88hq2qr_--_38MLvoj1ffr9jv3JhnNJTnKUM.css?delta=0&language=en&theme=nei&include=eJw1ytEKgCAMRuEXsnwk-dMxrOliTqi3j4iuDnycfFCprpbyHK4tDb-FRvwSshrFYvOErNhxBUHnCaYEcbJ_61Qji26Q5ZXa-QH_YCJ9" />
|
||
<link rel="stylesheet" media="all" href="/themes/custom/nei/css/style.css?sraguf" />
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"","currentPath":"node\/3629","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"en"},"pluralDelimiter":"\u0003","gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxdjFsOwjAMBC8U6iNFbmKZgPNQ7BTK6SmgCsrPrndkTbhSTFa7D0OtZq-2Cil8yoWOj5WYYT8c18pC3pCBt_jfE17wfoTZCRYeyORRjPruLmhpIS-b2EvFmArD73CFErDUGeWkoadmekCb5fXVsCN3bGeF2EdDmb5kGqWNWZKeKTpd1SjDjEpuSXRTeOeUaxxCT9WYZ50","theme":"nei","theme_token":null},"ajaxTrustedUrl":{"form_action_p_pvdeGsVG5zNF_XLGPTvYSKCf43t8qZYSwcfZl2uzM":true},"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"google\nnonGooglePixels\nnonGoogleScripts\nnonGoogleIframes","blocklist_classes":"customScripts\ncustomPixels","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-TLVNS7W"]},"user":{"uid":0,"permissionsHash":"c48594e108b5c1c2bea409821b71477d5bc2724c8cae6d31f1d985af0daab85c"}}</script>
|
||
<script src="/sites/default/files/js/js_WgzMsgqb-MiW-Z2aLffGQHepZwX2hWrEHSrb46WqZrk.js?scope=header&delta=0&language=en&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
||
<script src="https://script.crazyegg.com/pages/scripts/0117/6571.js" async></script>
|
||
<script src="/modules/contrib/google_tag/js/gtag.js?sraguf"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtm.js?sraguf"></script>
|
||
|
||
</head>
|
||
<body class="t-news_item t-node__3629 path-about-news-and-events-news-nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease">
|
||
<a href="#main-content" class="u-skip-link">
|
||
Skip to content
|
||
</a>
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-TLVNS7W"
|
||
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<div id="u-page-outer" class="u-outer">
|
||
<div class="views-element-container site-notice-block" id="block-views-block-site-notices-block-1">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="js-view-dom-id-bca3892fe522a94248c74087cbf8646ffbc018befc8d0e64978ba8c06dc01631 site-notices">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<img src="/themes/custom/nei/images/NEI-logo-tagline.svg" alt="" width="200" height="48" class="u-print-only">
|
||
<div class="r-global-header">
|
||
<div id="r-header-outer" class="r-header">
|
||
|
||
<div class="r-header-inner">
|
||
|
||
<div id="block-nei-branding" class="o-block--logo" role="banner">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-logo">
|
||
<a href="/" class="o-logo__link" title="Home" rel="home"><span class="o-logo__text">National Eye Institute</span> <span class="o-logo__tagline">Research Today… Vision Tomorrow</span></a>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div id="block-neimenubutton-2">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-menu-toggle"><button class="o-menu-toggle__btn" id="menu-toggle__btn" aria-controls="block-mainnavigation" aria-expanded="true">Menu</button></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="language-switcher-language-url has-no-translation" id="block-languageswitcher" role="navigation" aria-label="Language switcher">
|
||
|
||
|
||
<ul class="links">
|
||
<li class="is-active">
|
||
<a href="/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease" class="language-link is-active" lang="en" data-drupal-link-system-path="node/3629" aria-current="page">English</a>
|
||
</li>
|
||
<li>
|
||
<a href="/espanol/node/3629" class="language-link is-active" lang="es" data-drupal-link-system-path="node/3629" aria-current="page"> Español</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</div>
|
||
<div class="search-global c-search--global" data-drupal-selector="search-global" id="block-globalsearchform" role="search">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<form action="/about/news-and-events/news/nih-sponsored-study-stopped-new-drug-does-not-control-aids-related-eye-disease" method="post" id="search-global" accept-charset="UTF-8">
|
||
<div class="c-form__inner">
|
||
<div class="js-form-item form-item js-form-type-textfield form-item-global-terms js-form-item-global-terms">
|
||
<label for="edit-global-terms">Search the site</label>
|
||
<input data-drupal-selector="edit-global-terms" type="text" id="edit-global-terms" name="global-terms" value="" size="30" maxlength="128" placeholder="Search the site" class="form-text" />
|
||
|
||
</div>
|
||
<input data-drupal-selector="form-ngfudws52kswevpk65etaxfxlzywgsqchrvcsyhs9eg" type="hidden" name="form_build_id" value="form-NgfUDWs52KswEvpK65EtAXfXLzyWgSqChRVCSyhs9eg" />
|
||
<input data-drupal-selector="edit-search-global" type="hidden" name="form_id" value="search_global" />
|
||
<div data-drupal-selector="edit-global-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-global-actions"><input data-drupal-selector="edit-global-submit" type="submit" id="edit-global-submit" name="op" value="Search" class="button js-form-submit form-submit" />
|
||
</div>
|
||
|
||
</div>
|
||
</form>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="r-menu-primary">
|
||
<nav aria-label="Main navigation" id="block-mainnavigation" class="o-menu-main__outer">
|
||
|
||
<ul class="o-menu o-menu-main"> <li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/learn-about-eye-health" class="o-menu-main__link" data-drupal-link-system-path="node/39">Learn About Eye Health</a>
|
||
<ul class="o-menu o-menu-main__submenu"> <li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/healthy-vision" class="o-menu-main__link" data-drupal-link-system-path="node/788">Healthy Vision</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/eye-conditions-and-diseases" class="o-menu-main__link" data-drupal-link-system-path="learn-about-eye-health/eye-conditions-and-diseases">Eye Conditions and Diseases</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/eye-health-data-and-statistics" class="o-menu-main__link" data-drupal-link-system-path="node/825">Eye Health Data and Statistics</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/campaigns" class="o-menu-main__link" data-drupal-link-system-path="node/3859">Campaigns</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/vision-rehabilitation" class="o-menu-main__link" data-drupal-link-system-path="node/3865">Vision Rehabilitation</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/nei-for-kids" class="o-menu-main__link" data-drupal-link-system-path="node/162">NEI for Kids</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/learn-about-eye-health/outreach-resources" class="o-menu-main__link" data-drupal-link-system-path="node/125">Outreach Resources</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/grants-and-training" class="o-menu-main__link" data-drupal-link-system-path="node/143">Grants and Training</a>
|
||
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/grants-and-training/how-apply" class="o-menu-main__link" data-drupal-link-system-path="node/145">How to Apply</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/funding-opportunities" class="o-menu-main__link" data-drupal-link-system-path="node/144">Funding Opportunities</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/training-nei" class="o-menu-main__link" data-drupal-link-system-path="node/146">Training at NEI</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/funding-training-and-career-development" class="o-menu-main__link" data-drupal-link-system-path="node/152">Funding for Training and Career Development</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/policies-and-procedures" class="o-menu-main__link" data-drupal-link-system-path="node/149">Policies and Procedures</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/grants-and-training/Prior-Approval-Requests" class="o-menu-main__link" data-drupal-link-system-path="node/3918">Prior Approval Requests</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/resources-researchers" class="o-menu-main__link" data-drupal-link-system-path="node/150">Resources for Researchers</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/grants-and-training/contact-grants-and-funding-staff" class="o-menu-main__link" data-drupal-link-system-path="node/151">Contact Grants and Funding Staff</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/research" class="o-menu-main__link" data-drupal-link-system-path="node/41">Research at NEI</a>
|
||
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/about/news-and-events/news" title="Research News" class="o-menu-main__link" data-drupal-link-system-path="about/news-and-events/news">Research News</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/research/clinical-trials" class="o-menu-main__link" data-drupal-link-system-path="node/132">Clinical Trials</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/research/research-labs-and-branches" class="o-menu-main__link" data-drupal-link-system-path="node/270">Research Labs and Branches</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/research/jobs-and-training-opportunities-nei" class="o-menu-main__link" data-drupal-link-system-path="node/564">Jobs and Training Opportunities at NEI</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/research/seminars" class="o-menu-main__link" data-drupal-link-system-path="node/4048">NEI Research Seminars</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/about" class="o-menu-main__link" data-drupal-link-system-path="node/275">About NEI</a>
|
||
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/about/strategic-planning" class="o-menu-main__link" data-drupal-link-system-path="node/2857">Strategic Planning</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/news-and-events" class="o-menu-main__link" data-drupal-link-system-path="node/131">News and Events</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/goals-and-accomplishments" class="o-menu-main__link" data-drupal-link-system-path="node/281">Goals and Accomplishments</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/nei-history" class="o-menu-main__link" data-drupal-link-system-path="node/282">NEI History</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/nei-leadership" class="o-menu-main__link" data-drupal-link-system-path="node/415">NEI Leadership</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/budget-and-congress" class="o-menu-main__link" data-drupal-link-system-path="node/395">Budget and Congress</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/about/advisory-committees" class="o-menu-main__link" data-drupal-link-system-path="node/285">Advisory Committees</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/learn-about-eye-health/outreach-resources/national-eye-health-education-program" title="National Eye Health Education Program" class="o-menu-main__link" data-drupal-link-system-path="node/265">National Eye Health Education Program</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/about/donate-nei" class="o-menu-main__link" data-drupal-link-system-path="node/286">Donate to NEI</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</nav>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="o-overlay" aria-hidden="true"></div>
|
||
|
||
<div class="r-breadcrumb">
|
||
|
||
<div id="block-nei-breadcrumbs">
|
||
|
||
|
||
|
||
|
||
|
||
<nav aria-label="Breadcrumb">
|
||
<ol class="c-breadcrumb">
|
||
<li>
|
||
<a href="/">Home</a>
|
||
</li>
|
||
<li>
|
||
<a href="/about">About NEI</a>
|
||
</li>
|
||
<li>
|
||
<a href="/about/news-and-events">News and Events</a>
|
||
</li>
|
||
<li>
|
||
<a href="/about/news-and-events/news">NEI Research News</a>
|
||
</li>
|
||
<li>
|
||
NIH-Sponsored Study Stopped: New Drug Does Not Control AIDS-Related Eye Disease
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="r-page-header">
|
||
<div class="o-page-header">
|
||
|
||
<div id="block-nei-page-title">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<h1>
|
||
<span>NIH-Sponsored Study Stopped: New Drug Does Not Control AIDS-Related Eye Disease</span>
|
||
</h1>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="r-highlighted">
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
||
|
||
</div>
|
||
|
||
<div class="r-help">
|
||
|
||
</div>
|
||
<main id="main-content" class="r-main">
|
||
<div class="r-pre-content">
|
||
|
||
</div>
|
||
|
||
<div class="r-splitter">
|
||
<div class="r-content">
|
||
|
||
<div id="block-nei-content">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<article data-history-node-id="3629">
|
||
|
||
|
||
|
||
<div>
|
||
|
||
<div class="c-item__date">
|
||
August 15, 1996
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="c-item__tag c-item__tag--topic">
|
||
<a href="/about/news-and-events/news?topic=350" hreflang="en">Infectious Disease</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-item__tag c-item__tag--research-type">
|
||
<a href="/about/news-and-events/news?research=6" hreflang="en">Clinical Research</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-item__tag c-item__tag--source">
|
||
<a href="/about/news-and-events/news?source=123" hreflang="en">NEI</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-news__content">
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>Researchers have stopped patient enrollment and treatment in a study designed to evaluate the safety and effectiveness of a new drug to treat a blinding eye infection common in people with AIDS. The drug, MSL 109 (Protovir<sup>TM</sup>), did not slow the progression of CMV retinitis, the eye infection, in a clinical trial sponsored by the National Eye Institute (NEI) of the National Institutes of Health.</p><p>At the time the study was stopped, 209 of the 325 patients planned for the study had been treated. Of those, approximately 40% were newly diagnosed with CMV retinitis and 60% had previously been diagnosed with, and treated for, the disease. The patients were randomized to receive either MSL 109 or a placebo.</p><p>The investigators decided to terminate enrollment and treatment following the recommendation of an independent data and safety monitoring board. The recommendation was based on the lack of evidence of efficacy of MSL 109 for the treatment of CMV retinitis. The median time to progression of disease was 65 days in the group treated with MSL 109 and 66 days in the group taking the placebo.</p><p>In addition, study results suggest that patients with recurrent CMV retinitis who were taking the new drug had a higher mortality rate than similar patients taking a placebo. However, the meaning of this mortality difference was unclear because among this same group of study patients there was a lower than expected mortality rate in those given the placebo. The mortality difference was not observed inpatients with newly-diagnosed CMV retinitis.</p><p>“These results highlight the importance of conducting clinical trials to evaluate new therapies,” said Carl Kupfer, M.D., National Eye Institute director.</p><p>Up to 40 percent of people with AIDS develop CMV retinitis, which is caused by an organism called cytomegalovirus (CMV). Untreated, the disease destroys the retina, the light-sensing tissue that lines the back of the eye and is crucial for vision.</p><p>People with AIDS are among those most vulnerable to CMV, because their weakened immune systems are unable to resist potentially harmful organisms. Most people have been exposed to CMV, but their healthy immune systems do not allow infections to develop.</p><p>The Monoclonal Antibody CMV Retinitis Trial (MACRT), a nationwide, randomized, placebo-controlled study, tested MSL 109, a drug that mimics the body’s natural reaction to a foreign organism by acting like antibodies that are produced normally in healthy humans. MSL 109mimics the body’s antibody to the CMV virus. Patients in the study received either MSL 109 or a placebo as supplementary therapy to their primary treatment for CMV retinitis. The purpose of the study was to see if the supplementary therapy would keep the disease from spreading for a longer time period than their primary treatment alone.</p><p>A list of centers that participated in the study is attached.</p><p><em>The National Eye Institute is the Federal government’s lead agency for vision research, and supports more than 80percent of such research conducted in the United States. The MACRT study is part of a collaborative research group, Studies of the Ocular Complications of AIDS (SOCA), which was established through the National Institutes of Health. The SOCA study of MSL 109 was performed with funding from the National Eye Institute and Protein Design Labs, Inc., in collaboration with the National Institute of Allergy and Infectious Diseases’ AIDS Clinical Trials Group.</em></p><p> </p><p># # #</p><h3>Participating Clinical Centers<br>Monoclonal Antibody CMV-Retinitis Trial</h3><h3>Locations</h3><dl><dt><p>California</p></dt><dd><p>Gary N. Holland, M.D.<br>Jules Stein Eye Institute<br>University of California,<br>Los Angeles<br>(310) 825-9508</p></dd><dd><p>William R. Freeman, M.D.<br>Shiley Eye Center<br>University of California,<br>San Diego<br>(619) 534-3513</p></dd><dd><p>James O’Donnell, M.D.<br>Beckman Vision Center<br>University of California,<br>San Francisco<br>(415) 476-1921</p></dd><dt><p>Florida</p></dt><dd><p>Janet Davis, M.D.<br>Bascom Palmer Eye Institute<br>University of Miami<br>(305) 326-6377</p></dd><dd><p>Peter R. Pavan, M.D.<br>University of South Florida<br>Tampa<br>(813) 974-1530</p></dd><dt><p>Georgia</p></dt><dd><p>Daniel F. Martin, M.D.<br>The Emory Eye Clinic<br>Emory University<br>Atlanta<br>(404) 778-4815</p></dd><dt><p>Illinois</p></dt><dd><p>David V. Weinberg, M.D.<br>Department of Ophthalmology<br>Northwestern University<br>Chicago<br>(312) 908-8152</p></dd><dt><p>Louisiana</p></dt><dd><p>Bruce A. Barron, M.D.<br>LSU Eye Center<br>Louisiana State University<br>Medical Center<br>New Orleans<br>(504) 568-6700 ext. 307</p></dd><dt><p>Maryland</p></dt><dd><p>James P. Dunn, M.D.<br>The Wilmer Ophthalmological Institute<br>The Johns Hopkins University<br>School of Medicine<br>Baltimore<br>(410) 955-2966</p></dd><dt><p>New Jersey</p></dt><dd><p>Ronald Rescigno, M.D.<br>UMDNJ-New Jersey<br>Medical School<br>Newark<br>(201) 982-2065</p></dd><dt><p>New York</p></dt><dd><p>Murk-Hein Heinemann, M.D.<br>New York Hospital-Cornell Medical Center<br>(212) 746-2483</p></dd><dd><p>Alan H. Friedman, M.D.<br>Mount Sinai School of Medicine<br>New York City<br>(212) 241-6241</p></dd><dd><p>Dorothy Friedberg, M.D.<br>New York University<br>Medical Center<br>New York<br>(212) 687-0265</p></dd><dt><p>North Carolina</p></dt><dd><p>Charles van der Horst, M.D.<br>University of North Carolina<br>at Chapel Hill<br>(919) 966-2536</p></dd><dt><p>Texas</p></dt><dd><p>Richard Alan Lewis, M.D.<br>Cullen Eye Institute<br>Baylor College of Medicine<br>Houston<br>(713) 798-6100</p></dd></dl><h3>Resource Centers:</h3><dl><dt><p>Chairman’s Office</p></dt><dd><p>Douglas A. Jabs, M.D.<br>The Wilmer Ophthalmological Institute<br>The Johns Hopkins University School of Medicine<br>Baltimore, Maryland<br>(410) 955-1966</p></dd><dt><p>Coordinating Center</p></dt><dd><p>Curtis L. Meinert, Ph.D.<br>School of Hygiene and Public Health<br>The Johns Hopkins University<br>Baltimore, Baltimore<br>(410) 955-8198</p></dd><dt><p>Fundus Photograph Reading Center</p></dt><dd><p>Matthew D. Davis, M.D.<br>Department of Ophthalmology<br>University of Wisconsin<br>Madison, Wisconsin<br>(608) 263-6071</p></dd><dt><p>Drug Distribution Center:</p></dt><dd><p>Mark Walls, R.Ph.<br>McKessan BioServices<br>Rockville, Maryland<br>(301) 762-0069</p></dd><dt><p>Central Laboratories/Repository:</p></dt><dd><p>Richard B. Pollard, M.D.<br>University of Texas Medical Branch<br>Galveston, Texas<br>(409) 772-4979</p></dd><dd><p>Colin Jordan, M.D.<br>Division of Infectious Diseases<br>University of Minnesota<br>Minneapolis, Minnesota<br>(612) 624-9996</p></dd><dt><p>NEI Representative:</p></dt><dd><p>Natalie Kurinij, Ph.D.<br>National Eye Institute<br>(301) 496-5983</p></dd></dl><p># # #</p><h3>Citations</h3><ul><li>McCarthy M. CMV Retinitis Monoclonal Antibody Trial Halted. <em>Lancet</em>. 1996 Aug 31. <a href="https://pubmed.ncbi.nlm.nih.gov/8774578/">PubMed</a></li></ul>
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</article>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
<aside class="r-sidebar" role="complementary">
|
||
|
||
<div class="views-element-container" id="block-views-block-nei-sidebar-block-1">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="js-view-dom-id-9e45285e2ed1e37154488693539cd8e6d4600091b128280433e5d532ff9f3935 nei-sidebar">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</aside>
|
||
</div>
|
||
</main>
|
||
|
||
<div class="r-footer">
|
||
<footer class="o-footer" role="contentinfo">
|
||
|
||
<div id="block-footer-2">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-footer__row">
|
||
<div class="o-footer__group o-footer__group--logo"><a class="o-logo__link" href="/" rel="home" title="Home"><span class="o-logo__text">National Eye Institute</span></a>
|
||
<ul class="o-menu-social">
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--facebook outlink-ignore" href="https://www.facebook.com/NationalEyeInstitute">Facebook</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--twitter outlink-ignore" href="https://twitter.com/NatEyeInstitute">Twitter</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--linkedin outlink-ignore" href="https://www.linkedin.com/company/national-eye-institute-nei">LinkedIn</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--youtube outlink-ignore" href="https://www.youtube.com/user/neinih">YouTube</a></li>
|
||
</ul>
|
||
|
||
<p> </p>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--contact">
|
||
<h2 class="o-footer__title">Contact NEI</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/contact-us/">Contact Us</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/about-nih/visitor-information">Visit NIH</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://list.nih.gov/cgi-bin/wa.exe?SUBED1=insidenei&A=1">Get Email Updates from NEI</a></li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--policies">
|
||
<h2 class="o-footer__title">Policies</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/accessibility-information">Accessibility</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/nondiscrimination-notice-language-assistance-services">Information in Other Languages</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/nei-website-privacy-policy">Privacy</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/freedom-information-act">Freedom of Information Act (FOIA)</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/disclaimers">Disclaimers</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/web-policies ">Web Policies</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html ">Vulnerability Disclosure</a></li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--employees">
|
||
<h2 class="o-footer__title">For NEI Employees</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov">Intranet</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov/hr/Pages/emergency.aspx">Emergency Information</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://ned.nih.gov/search/search.aspx">NIH Staff Directory</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="o-footer__row">
|
||
<div class="o-footer__full o-footer__full--parent">
|
||
<ul class="o-menu-footer o-menu-footer--swing">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/">NIH.gov</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://hhs.gov/">HHS.gov</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://usa.gov/">USA.gov</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</footer>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-lb-wrapper" id="lb-wrapper" aria-hidden="true">
|
||
<div class="c-lb-overlay" tabindex="-1"></div>
|
||
<div role="dialog" class="c-lb" id="lb">
|
||
<div class="c-lb-header">
|
||
<button class="c-lb-close-btn"><span class="c-lb-close-btn-text">Close</span><span class="c-lb-close-btn-text times" aria-hidden="true">×</span></button>
|
||
</div>
|
||
<figure class="c-lb-figure">
|
||
<figcaption class="c-lb-caption"></figcaption>
|
||
</figure>
|
||
</div>
|
||
</div>
|
||
|
||
<script src="/sites/default/files/js/js_agazM-qm5cOcplNZo9kNIWFtUrwt0V1xgAKtLyM44Us.js?scope=footer&delta=0&language=en&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
||
<script src="/themes/custom/nei/js/scripts.js?sraguf"></script>
|
||
|
||
</body>
|
||
</html>
|