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New therapeutic approach may help treat age-related macular degeneration effectively
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Inhibiting a gene involved in the abnormal growth of blood vessels in certain ocular disorders may reduce retinal neovascularization, researchers report in The American Journal of Pathology
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February 22, 2021
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<a href="/about/news-and-events/news?topic=246" hreflang="en">Age-Related Macular Degeneration</a>
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<a href="/about/news-and-events/news?topic=13" hreflang="en">Diabetic Eye Disease</a>
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<img src="https://www.nei.nih.gov/sites/default/files/styles/large/public/2021-02/RUNX1_creditAJP.jpg?itok=p0AmiJyT" alt="Schematic showing reduction of neovascularization with injection of both anti-VEGF and RUNX1 inhibitor" width="3000" height="2100">
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<p>RUNX1 inhibition combined with anti–vascular endothelial growth factor (anti-VEGF) therapy achieves better control of experimental choroidal neovascularization activity compared to monotherapy. Image credit: The American Journal of Pathology</p>
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<p>Runt-related transcription factor 1 (RUNX1) has been linked to retinal neovascularization and the development of abnormal blood vessels, which result in vision loss in diabetic retinopathy. Now, scientists have found that RUNX1 inhibition presents a new therapeutic approach in the treatment of age-related macular degeneration (AMD), which is the leading cause of blindness in the elderly worldwide. Their results are reported in The American Journal of Pathology, published by Elsevier.</p><p>“RUNX1 inhibitors hold significant promise to complement or replace anti-VEGF therapies for patients in which anti-VEGF therapy is no longer effective, and with the potential to be administered topically it could be transformative in the field,” suggests co-lead investigator Joseph F. Arboleda-Velasquez, MD, PhD, Assistant Scientist, Schepens Eye Research Institute of Mass Eye and Ear, and Assistant Professor of Ophthalmology, Harvard Medical School, Boston, MA, USA.</p>
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