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<p>Scientists at the University of Utah have invented a method for synthesizing large enough quantities of very-long-chain polyunsaturated fatty acids (VLC-PUFAs) to evaluate their potential sight-preserving properties. The method and the results of the first study to use it were published in <em>Proceedings of the National Academy of Sciences of the United States of America (PNAS) </em>this week.</p><p>The study determined that VLC-PUFA supplementation increased levels of the lipids in the retina and also improved visual function in normal mice and in mice with a defect in the ELOVL4 enzyme, which is involved in the body's production of VLC-PUFAs.</p><p>“Synthesizing VLC-PUFAs opens up a whole new area of study, and these first results are very promising,” said the John A. Moran Eye Center’s <a href="https://healthcare.utah.edu/fad/mddetail.php?physicianID=u0030465&name=paul-s-bernstein">Paul S. Bernstein, MD, Ph.D.</a>, the paper’s corresponding author. “Our results raise interesting questions about how orally administered VLC-PUFAs improve vision, how they are carried in the bloodstream, and how they are selectively targeted to the retina. The VLC-PUFA formulation, dosage, and timing of the intervention first need to be optimized, and then the underlying mechanisms will need to be defined.”</p>
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