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Temple Scientists Regenerate Neurons in Mice with Spinal Cord Injury and Optic Nerve Damage
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<span>Temple Scientists Regenerate Neurons in Mice with Spinal Cord Injury and Optic Nerve Damage</span>
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April 30, 2020
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<p>Like power lines in an electrical grid, long wiry projections that grow outward from neurons – structures known as axons – form interconnected communication networks that run from the brain to all parts of the body. But unlike an outage in a power line, which can be fixed, a break in an axon is permanent. Each year thousands of patients confront this reality, facing life-long losses in sensation and motor function from spinal cord injury and related conditions in which axons are badly damaged or severed.</p><p>New research by scientists at the Lewis Katz School of Medicine Temple University (LKSOM) shows, however, that gains in functional recovery from these injuries may be possible, thanks to a molecule known as Lin28, which regulates cell growth. In a study published online in the journal <em>Molecular Therapy</em>, the Temple researchers describe the ability of Lin28 – when expressed above its usual levels – to fuel axon regrowth in mice with spinal cord injury or optic nerve injury, enabling repair of the body's communication grid.</p>
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