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<span>Unit on Clinical Investigation of Retinal Disease</span>
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<h2>About our work</h2>
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<div><div class="c-text">
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<p>The Unit on Clinical Investigation of Retinal Disease’s interest is in understanding the retinal disease from clinical study to provide insights into disease pathogenesis, developing outcome measures for clinical trials and conducting interventional trials.</p><p>Our group uses multi-disciplinary approaches to clinical study aimed at understanding the patterns of photoreceptor dysfunction and degeneration in retinal disease. The retina is uniquely positioned for advancement in therapeutic intervention for disease. Its accessibility, unique biology and advances in functional assessment tools and imaging make the focus poised for progress in advancing translational research.</p>
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<h2>Current research</h2>
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<div><div class="c-text">
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<p>The current research areas include retinitis pigmentosa (RP), late onset retinal degeneration (LORD), age-related macular degeneration (AMD) and drug toxicity (hydroxychloroquine) induced retinal degeneration. The ability to draw on the large population of patients with both common and rare diseases that are seen at the NEI enable us to study the state of photoreceptor dysfunction across diseases and severities and to implement treatments to change the trajectory of cell death.</p>
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Ongoing active clinical trials
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<p><a href="https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?A_2019-EI-0056.html"><strong>19-EI-0056:</strong></a> A Survey Study of Retinitis Pigmentosa (RP) Clinical Measures and Repeatability Testing of Potential Outcome Measures</p><p><a href="https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?A_2018-EI-0068.html"><strong>18-EI-0068:</strong></a> An Investigation of Vitamin A Palmitate Supplementation in Patients with Reticular Pseudodrusen (RPD) and Delayed Dark AdaptationAn Investigation of Vitamin A Palmitate Supplementation in Patients with Reticular Pseudodrusen (RPD) and Delayed Dark Adaptation</p><p><a href="https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?A_2018-EI-0067.html"><strong>18-EI-0067:</strong></a> An Investigation of Vitamin A Palmitate Supplementation in Patients with Age-Related Macular Degeneration (and without reticular pseudodrusen) and Delayed Dark Adaptation</p><p><a href="https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?A_2017-EI-0112.html"><strong>17-EI-0112:</strong></a> A Long-term Follow-up Study of Participants Enrolled in 11-EI-0147: Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration (DA_AMD)</p><p><a href="https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?A_2011-EI-0147.html"><strong>11-EI-0147:</strong></a> Longitudinal Investigation of Dark Adaptation in Participants with Age-Related Macular Degeneration</p><p><a href="https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?A_2010-EI-0140.html"><strong>10-EI-0140:</strong></a> Genotype-Phenotype Study of Patients with Plaquenil -Induced Retinal Toxicity, with Evaluation of the ABCA4 Gene</p><p><a href="https://clinicalstudies.info.nih.gov/ProtocolDetails.aspx?A_2003-EI-0033.html"><strong>03-EI-0033:</strong></a> X-Linked Juvenile Retinoschisis - Clinical and Molecular Studies</p>
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</div>
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</div>
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<div class="c-section">
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<h2>Selected publications</h2>
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||
<div>
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<div><div class="c-text">
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<p>Chen KG, Alvarez JA, Yazdanie M, Papudesu C, Wong WT, Wiley HE, Keenan TD, Chew EY, Ferris FL 3rd, Cukras CA. Longitudinal Study of Dark Adaptation as a Functional Outcome Measure for Age-Related Macular Degeneration. Ophthalmology. 2019 Jun;126(6):856-865.</p><p>Flamendorf J, Agrón E, Wong WT, Thompson D, Wiley HE, Doss EL, Al-Holou S, Ferris FL 3rd, Chew EY, Cukras C. <a href="http://www.ncbi.nlm.nih.gov/pubmed/26253372">Impairments in Dark Adaptation Are Associated with Age-Related Macular Degeneration Severity and Reticular Pseudodrusen.</a> Ophthalmology. 2015 Oct;122(10):2053-62. PMID: 26253372</p><p>Yazdanie M, Alvarez J, Agrón E, Wong WT, Wiley HE, Ferris FL 3rd, Chew EY, Cukras C. Decreased Visual Function Scores on a Low Luminance Questionnaire Is Associated with Impaired Dark Adaptation. Ophthalmology. 2017 Jun 8.</p><p>Allahdina AM, Stetson PF, Vitale S, Wong WT, Chew EY, Iii FLF, Sieving PA, Cukras C. <a href="https://www.ncbi.nlm.nih.gov/pubmed/29677357">Optical Coherence Tomography Minimum Intensity as an Objective Measure for the Detection of Hydroxychloroquine Toxicity.</a> Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1953-1963.</p><p>Cukras C, Huynh N, Vitale S, Wong WT, Ferris FL 3rd, Sieving PA. <a href="http://www.ncbi.nlm.nih.gov/pubmed/25444344">Subjective and Objective Screening Tests for Hydroxychloroquine Toxicity.</a> Ophthalmology. 2014 Oct 14. pii: S0161-6420(14)00735-0.</p>
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||
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||
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||
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|
||
</div>
|
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|
||
<div class="c-group__staff-list c-section" id="key-staff">
|
||
<h2>Unit on Clinical Investigation of Retinal Disease key staff</h2>
|
||
<div class="views-element-container">
|
||
<div class="js-view-dom-id-8851ee0a0775b38d7fc5c131f4de4225a6bd925d38f99e87fd2a486161ccded5 lab-staff">
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<th id="view-title-table-column" class="views-field views-field-title" scope="col">Name</th>
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<th id="view-field-email-table-column" class="views-field views-field-field-email" scope="col">Email</th>
|
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<th id="view-field-phone-table-column" class="views-field views-field-field-phone" scope="col">Phone</th>
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</thead>
|
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<tbody>
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||
<td headers="view-title-table-column" class="views-field views-field-title"><a href="/research/research-labs-and-branches/we-are-nei-intramural/tharindu-de-silva" hreflang="en">Tharindu de Silva</a> </td>
|
||
<td headers="view-field-lab-staff-title-table-column" class="views-field views-field-field-lab-staff-title">Staff Scientist </td>
|
||
<td headers="view-field-email-table-column" class="views-field views-field-field-email"><a href="mailto:tharindu.desilva@nih.gov">tharindu.desilva@nih.gov</a> </td>
|
||
<td headers="view-field-phone-table-column" class="views-field views-field-field-phone">301-496-9058 </td>
|
||
</tr>
|
||
<tr>
|
||
<td headers="view-title-table-column" class="views-field views-field-title"><a href="/research/research-labs-and-branches/we-are-nei-intramural/elliott-vanderford" hreflang="en">Elliott Vanderford</a> </td>
|
||
<td headers="view-field-lab-staff-title-table-column" class="views-field views-field-field-lab-staff-title">Postbac IRTA </td>
|
||
<td headers="view-field-email-table-column" class="views-field views-field-field-email"><a href="mailto:elliott.vanderford@nih.gov">elliott.vanderford@nih.gov</a> </td>
|
||
<td headers="view-field-phone-table-column" class="views-field views-field-field-phone">301-451-7362 </td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
|
||
|
||
|
||
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||
|
||
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||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="c-group__staff-list c-section" id="alumni-staff">
|
||
<div class="views-element-container">
|
||
<div class="js-view-dom-id-dcd8baee43e1cfa7a7d1528b73e10f96433200c84f50a06d1ffb5e414ac11a44 lab-alumni">
|
||
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</div>
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||
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||
|
||
</div>
|
||
|
||
</article>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
<div class="views-element-container" id="block-views-block-news-page-block-5">
|
||
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||
|
||
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||
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||
<div>
|
||
|
||
<div class="c-filter js-view-dom-id-375669b0c2aa1cdc2e968e7b093539934e989121fde3a672a4d22b1e4a2096a4 news-page news-page--block_5">
|
||
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||
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||
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||
<div class="news-header">
|
||
<h2 class="c-filter__heading">News from this lab</h2>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-sidebar-widget__list-item views-row">
|
||
|
||
<div class="c-teaser">
|
||
<div class="c-teaser__image">
|
||
|
||
<img loading="lazy" src="/sites/default/files/styles/thumbnail/public/2023-11/Emily%20Chew.jpg?itok=9iyjqgP0" width="200" height="200" alt="Emily Chew" />
|
||
|
||
|
||
|
||
</div>
|
||
<div class="c-teaser__content">
|
||
<h3 class="c-teaser__header">
|
||
<a class="c-teaser__link" href="/about/news-and-events/news/emily-chew-named-nih-distinguished-investigator">
|
||
Emily Chew named NIH distinguished investigator
|
||
</a>
|
||
</h3>
|
||
<p class="c-teaser__date">
|
||
<time datetime="2023-11-21T16:35:28-05:00">November 21, 2023</time>
|
||
</p>
|
||
<div class="c-teaser__summary">
|
||
A longstanding member of the NEI/NIH community, Emily Chew, M.D., has been promoted to the title of NIH Distinguished Investigator for her tireless and prolific work as a care provider and clinical trialist.
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="c-sidebar-widget__list-item views-row">
|
||
|
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<div class="c-teaser">
|
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<div class="c-teaser__image">
|
||
|
||
<img loading="lazy" src="/sites/default/files/styles/thumbnail/public/2021-07/Tiarnan%20Keenan-6885%20cropped.jpg?itok=5Qsr1q88" width="200" height="200" alt="Tiarnan Keenan" />
|
||
|
||
|
||
|
||
</div>
|
||
<div class="c-teaser__content">
|
||
<h3 class="c-teaser__header">
|
||
<a class="c-teaser__link" href="/about/news-and-events/news/patients-use-device-monitor-amd-home">
|
||
Patients use device to monitor AMD at home
|
||
</a>
|
||
</h3>
|
||
<p class="c-teaser__date">
|
||
<time datetime="2021-07-16T10:44:37-04:00">July 16, 2021</time>
|
||
</p>
|
||
<div class="c-teaser__summary">
|
||
Tiarnan Keenan, NEI Division of Epidemiology and Clinical Applications, and colleagues found that people with age-related macular degeneration (AMD) can successfully use the Notal Home OCT device to monitor their disease.
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
<div class="c-sidebar-widget__list-item views-row">
|
||
|
||
<div class="c-teaser">
|
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<div class="c-teaser__image">
|
||
|
||
<img loading="lazy" src="/sites/default/files/styles/thumbnail/public/news/capsules%20no%20attribution.jpg?itok=gBiEDZws" width="200" height="200" alt="capsules" />
|
||
|
||
|
||
|
||
</div>
|
||
<div class="c-teaser__content">
|
||
<h3 class="c-teaser__header">
|
||
<a class="c-teaser__link" href="/about/news-and-events/news/omega-3s-fish-oil-supplements-no-better-placebo-dry-eye">
|
||
Omega-3s from fish oil supplements no better than placebo for dry eye
|
||
</a>
|
||
</h3>
|
||
<p class="c-teaser__date">
|
||
<time datetime="2018-04-13T00:00:00-04:00">April 13, 2018</time>
|
||
</p>
|
||
<div class="c-teaser__summary">
|
||
Omega-3 fatty acid supplements taken orally proved no better than placebo at relieving symptoms or signs of dry eye, according to the findings of a well-controlled trial funded by the National Eye Institute (NEI), part of the National Institutes of Health
|
||
</div>
|
||
</div>
|
||
</div>
|
||
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|
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|
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<p class="u-text-center"><a class="c-btn" href="/about/news-and-events/news">See all NEI and Grantee news</a></p>
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|
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|
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<img src="/sites/default/files/styles/400px_square_crop/public/2019-04/shutterstock_605501567_333.jpg?itok=yofmpBZG" alt="">
|
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</figure>
|
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|
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<h2 class="c-callout__heading">Research at NEI</h2>
|
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<ul><li><a href="/research/research-labs-and-branches">Research Labs and Branches</a></li><li><a href="/research/research-labs-and-branches/we-are-nei-intramural">Principal Investigators</a></li><li><a href="/grants-and-training/training-nei">Training at NEI</a></li><li><a href="/about/news-and-events/news">Research News</a></li></ul>
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<p class="views-element-container c-last-updated" id="block-views-block-nei-last-updated-block-1"><strong>Last updated:</strong> December 27, 2024</p>
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<span>Unit on Clinical Investigation of Retinal Disease</span>
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10 Center Drive<br>
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|
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Building 10-CRC Room 3-2531
|
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<br>
|
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Bethesda,
|
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Maryland
|
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20892-1204
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<div><span>Phone:</span> 301-496-6583</div>
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