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<meta name="description" content="Researchers at the University of New Hampshire have reported the first structural model for a key enzyme, and its activating protein, that can play a role in some genetically inherited eye diseases like retinitis pigmentosa and night blindness." />
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"name": "UNH Researchers Solve Protein Structure Associated with Inherited Retinal Diseases",
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UNH Researchers Solve Protein Structure Associated with Inherited Retinal Diseases
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<span>UNH Researchers Solve Protein Structure Associated with Inherited Retinal Diseases</span>
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December 23, 2019
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<img src="https://www.nei.nih.gov/sites/default/files/styles/small/public/2019-12/pde6_transducin_model_retina_.jpg?itok=jHHJDi7X" alt="Model of protein structure with 4 protein chains" width="2455" height="3000">
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<p>Model by UNH researchers of the activated complex of the PDE6 dimer (green and cyan) with two transducin subunits (blue and orange) associated with the photoreceptor membrane (gray). Photo credit: UNH</p>
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<p>Researchers at the University of New Hampshire have reported the first structural model for a key enzyme, and its activating protein, that can play a role in some genetically inherited eye diseases like retinitis pigmentosa and night blindness.</p><p>In the study, recently published in the Journal of Biological Chemistry, researchers reported how they were able to use chemical cross-linking combined with mass spectrometric analysis to resolve the structure of PDE6 in its nonactivated and transducin-activated states. This approach permitted visualization of flexible regions of individual PDE6 catalytic and inhibitory subunits that were poorly resolved in previous work as well as the overall molecular architecture of the activated protein complex.</p>
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<a href="https://www.unh.edu/unhtoday/news/release/2019/12/23/unh-researchers-solve-protein-structure-associated-inherited-retinal" class="c-link__link">Read more at the University of New Hampshire News</a>
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