604 lines
28 KiB
Text
604 lines
28 KiB
Text
|
||
<!DOCTYPE html>
|
||
<html lang="es" dir="ltr">
|
||
<head>
|
||
<meta charset="utf-8" />
|
||
<meta name="description" content="National Eye Institute-funded scientists using gene editing corrected a mutation in a mouse model of retinitis pigmentosa, an inherited blinding eye disorder. The gene editing strategy restored production of rhodopsin, and retinal function and structure" />
|
||
<meta name="keywords" content="Retina,Regenerative Medicine,Genetics,Gene Therapy" />
|
||
<meta name="google" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw,lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
||
<meta name="google-site-verification" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw" />
|
||
<meta name="google-site-verification" content="lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
||
<meta name="google-site-verification" content="UDfyeEAWNX_rJUHwog9j1kziEnByGwhkSJGLJclUWDA" />
|
||
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
||
<script type="application/ld+json">{
|
||
"@context": "https://schema.org",
|
||
"@graph": [
|
||
{
|
||
"@type": "NewsArticle",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/crispr-gene-editing-promising-blinding-disease-retinitis-pigmentosa",
|
||
"name": "CRISPR gene editing promising for blinding disease retinitis pigmentosa",
|
||
"headline": "CRISPR gene editing promising for blinding disease retinitis pigmentosa",
|
||
"image": {
|
||
"@type": "ImageObject",
|
||
"representativeOfPage": "False",
|
||
"url": "https://www.nei.nih.gov/sites/default/files/styles/medium/public/2024-11/layers%20of%20retina.jpeg?itok=EXOx3V1p",
|
||
"width": "800",
|
||
"height": "719"
|
||
},
|
||
"datePublished": "2024-11-27T09:25:51-0500",
|
||
"dateModified": "2025-01-24T11:17:18-0500",
|
||
"author": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/crispr-gene-editing-promising-blinding-disease-retinitis-pigmentosa",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
},
|
||
"publisher": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/crispr-gene-editing-promising-blinding-disease-retinitis-pigmentosa",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
}
|
||
},
|
||
{
|
||
"@type": "WebPage",
|
||
"@id": "https://www.nei.nih.gov/about/news-and-events/news/crispr-gene-editing-promising-blinding-disease-retinitis-pigmentosa",
|
||
"breadcrumb": {
|
||
"@type": "BreadcrumbList",
|
||
"itemListElement": [
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 1,
|
||
"name": "Home",
|
||
"item": "https://www.nei.nih.gov/espanol"
|
||
},
|
||
{
|
||
"@type": "ListItem",
|
||
"position": 2,
|
||
"name": "CRISPR gene editing promising for blinding disease retinitis pigmentosa",
|
||
"item": "https://www.nei.nih.gov/espanol/node/4334"
|
||
}
|
||
]
|
||
},
|
||
"author": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
},
|
||
"publisher": {
|
||
"@type": "GovernmentOrganization",
|
||
"@id": "https://www.nei.nih.gov",
|
||
"name": "National Eye Institute",
|
||
"url": "https://www.nei.nih.gov"
|
||
}
|
||
}
|
||
]
|
||
}</script>
|
||
<link rel="icon" type="image/png" href="/themes/custom/nei/images/favicon.png" />
|
||
<link rel="apple-touch-icon" href="/themes/custom/nei/images/apple-touch-icon.png" />
|
||
<meta name="last-updated" content="Jan 24, 2025, 11:17:18 AM" />
|
||
<link rel="icon" href="/themes/custom/nei/favicon.ico" type="image/vnd.microsoft.icon" />
|
||
<link rel="alternate" hreflang="en" href="https://www.nei.nih.gov/about/news-and-events/news/crispr-gene-editing-promising-blinding-disease-retinitis-pigmentosa" />
|
||
<link rel="canonical" href="https://www.nei.nih.gov/about/news-and-events/news/crispr-gene-editing-promising-blinding-disease-retinitis-pigmentosa" />
|
||
<link rel="shortlink" href="https://www.nei.nih.gov/node/4334" />
|
||
|
||
<title>CRISPR gene editing promising for blinding disease retinitis pigmentosa | National Eye Institute</title>
|
||
<link rel="preload" href="/themes/custom/nei/fonts/Aleo-Bold.woff2" as="font" type="font/woff2" crossorigin>
|
||
<link rel="preload" href="/themes/custom/nei/fonts/Lato-Regular.woff2" as="font" type="font/woff2" crossorigin>
|
||
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_PGSk_7b88hq2qr_--_38MLvoj1ffr9jv3JhnNJTnKUM.css?delta=0&language=es&theme=nei&include=eJw1ytEKgCAMRuEXsnwk-dMxrOliTqi3j4iuDnycfFCprpbyHK4tDb-FRvwSshrFYvOErNhxBUHnCaYEcbJ_61Qji26Q5ZXa-QH_YCJ9" />
|
||
<link rel="stylesheet" media="all" href="/themes/custom/nei/css/style.css?sraguf" />
|
||
|
||
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"espanol\/","currentPath":"node\/4334","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"es"},"pluralDelimiter":"\u0003","gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxdjFsOwjAMBC8U6iNFbmKZgPNQ7BTK6SmgCsrPrndkTbhSTFa7D0OtZq-2Cil8yoWOj5WYYT8c18pC3pCBt_jfE17wfoTZCRYeyORRjPruLmhpIS-b2EvFmArD73CFErDUGeWkoadmekCb5fXVsCN3bGeF2EdDmb5kGqWNWZKeKTpd1SjDjEpuSXRTeOeUaxxCT9WYZ50","theme":"nei","theme_token":null},"ajaxTrustedUrl":{"form_action_p_pvdeGsVG5zNF_XLGPTvYSKCf43t8qZYSwcfZl2uzM":true},"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"google\nnonGooglePixels\nnonGoogleScripts\nnonGoogleIframes","blocklist_classes":"customScripts\ncustomPixels","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-TLVNS7W"]},"user":{"uid":0,"permissionsHash":"c48594e108b5c1c2bea409821b71477d5bc2724c8cae6d31f1d985af0daab85c"}}</script>
|
||
<script src="/sites/default/files/js/js_WgzMsgqb-MiW-Z2aLffGQHepZwX2hWrEHSrb46WqZrk.js?scope=header&delta=0&language=es&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
||
<script src="https://script.crazyegg.com/pages/scripts/0117/6571.js" async></script>
|
||
<script src="/modules/contrib/google_tag/js/gtag.js?sraguf"></script>
|
||
<script src="/modules/contrib/google_tag/js/gtm.js?sraguf"></script>
|
||
|
||
</head>
|
||
<body class="t-news_item t-node__4334 path-node-4334">
|
||
<a href="#main-content" class="u-skip-link">
|
||
Skip to content
|
||
</a>
|
||
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-TLVNS7W"
|
||
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
||
|
||
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
||
|
||
<div id="u-page-outer" class="u-outer">
|
||
<div class="views-element-container site-notice-block" id="block-views-block-site-notices-block-1">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="js-view-dom-id-0ad8bc2e426a8b1cafef8a2990c96d7d973a7a2e7a770918fcf24ec9352cfecc site-notices">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<img src="/themes/custom/nei/images/NEI-logo-tagline.svg" alt="" width="200" height="48" class="u-print-only">
|
||
<div class="r-global-header">
|
||
<div id="r-header-outer" class="r-header">
|
||
|
||
<div class="r-header-inner">
|
||
|
||
<div id="block-nei-branding" class="o-block--logo" role="banner">
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-logo">
|
||
<a href="/espanol" class="o-logo__link" title="Home" rel="home"><span class="o-logo__text">National Eye Institute</span> <span class="o-logo__tagline">Research Today… Vision Tomorrow</span></a>
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
<div id="block-neimenubutton-2">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-menu-toggle"><button class="o-menu-toggle__btn" id="menu-toggle__btn" aria-controls="block-mainnavigation" aria-expanded="true">Menú</button></div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div class="language-switcher-language-url has-no-translation" id="block-languageswitcher" role="navigation" aria-label="Language switcher">
|
||
|
||
|
||
<ul class="links">
|
||
<li>
|
||
<a href="/about/news-and-events/news/crispr-gene-editing-promising-blinding-disease-retinitis-pigmentosa" class="language-link is-active" lang="en" data-drupal-link-system-path="node/4334" aria-current="page">English</a>
|
||
</li>
|
||
<li class="is-active">
|
||
<a href="/espanol/node/4334" class="language-link is-active" lang="es" data-drupal-link-system-path="node/4334" aria-current="page"> Español</a>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</div>
|
||
<div class="search-global c-search--global" data-drupal-selector="search-global" id="block-globalsearchform" role="search">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<form action="/espanol/node/4334" method="post" id="search-global" accept-charset="UTF-8">
|
||
<div class="c-form__inner">
|
||
<div class="js-form-item form-item js-form-type-textfield form-item-global-terms js-form-item-global-terms">
|
||
<label for="edit-global-terms">Buscar en la página</label>
|
||
<input data-drupal-selector="edit-global-terms" type="text" id="edit-global-terms" name="global-terms" value="" size="30" maxlength="128" placeholder="Buscar en la página" class="form-text" />
|
||
|
||
</div>
|
||
<input data-drupal-selector="form-7c7xsreh5wx-jajqpteoqfed1hpke90l3uj-rjxio-c" type="hidden" name="form_build_id" value="form-7C7xsrEH5WX-jAJqpTEoqfEd1hpKE90l3uj-RjXIo-c" />
|
||
<input data-drupal-selector="edit-search-global" type="hidden" name="form_id" value="search_global" />
|
||
<div data-drupal-selector="edit-global-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-global-actions"><input data-drupal-selector="edit-global-submit" type="submit" id="edit-global-submit" name="op" value="Buscar" class="button js-form-submit form-submit" />
|
||
</div>
|
||
|
||
</div>
|
||
</form>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
<div class="r-menu-primary">
|
||
<nav aria-label="Main navigation" id="block-mainnavigation" class="o-menu-main__outer">
|
||
|
||
<ul class="o-menu o-menu-main"> <li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/espanol/aprenda-sobre-la-salud-ocular" class="o-menu-main__link" data-drupal-link-system-path="node/39">Aprenda sobre la salud ocular</a>
|
||
<ul class="o-menu o-menu-main__submenu"> <li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/vision-saludable" class="o-menu-main__link" data-drupal-link-system-path="node/788">Visión saludable</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/enfermedades-y-afecciones-de-los-ojos" class="o-menu-main__link" data-drupal-link-system-path="learn-about-eye-health/eye-conditions-and-diseases">Enfermedades y afecciones de los ojos</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/datos-y-estadisticas-relacionadas-con-la-salud-ocular" class="o-menu-main__link" data-drupal-link-system-path="node/825">Datos y estadísticas relacionadas con la salud ocular</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/espanol/aprenda-sobre-la-salud-ocular/rehabilitacion-visual" class="o-menu-main__link" data-drupal-link-system-path="node/3865">Rehabilitación visual</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/campanas-de-difusion-y-recursos" class="o-menu-main__link" data-drupal-link-system-path="node/125">Campañas de difusión y recursos</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/espanol/acerca-del-NEI" class="o-menu-main__link" data-drupal-link-system-path="node/275">Acerca del Instituto Nacional del Ojo</a>
|
||
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/espanol/acerca-del-NEI/planificacion-estrategica-en-el-nei" class="o-menu-main__link" data-drupal-link-system-path="node/2857">Planificación estratégica en el NEI</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/metas-y-logros" class="o-menu-main__link" data-drupal-link-system-path="node/281">Metas y logros</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/historia-del-nei" class="o-menu-main__link" data-drupal-link-system-path="node/282">Historia del NEI</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/lideres-del-instituto-nacional-del-ojo-nei" class="o-menu-main__link" data-drupal-link-system-path="node/415">Líderes del Instituto Nacional del Ojo (NEI)</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/el-presupuesto-y-el-congreso" class="o-menu-main__link" data-drupal-link-system-path="node/395">El presupuesto y el Congreso</a>
|
||
</li>
|
||
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/comites-asesores" class="o-menu-main__link" data-drupal-link-system-path="node/285">Comités asesores</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/espanol/aprenda-sobre-la-salud-ocular/campanas-de-difusion-y-recursos/programa-nacional-de-educacion-sobre-la-salud-del-ojo" title="National Eye Health Education Program" class="o-menu-main__link" data-drupal-link-system-path="node/265">Programa Nacional de Educación sobre la Salud del Ojo</a>
|
||
</li>
|
||
<li class="o-menu-main__item"> <a href="/espanol/acerca-del-NEI/done-al-instituto-nacional-del-ojo-nei" class="o-menu-main__link" data-drupal-link-system-path="node/286">Done al Instituto Nacional del Ojo (NEI)</a>
|
||
</li>
|
||
</ul>
|
||
</li>
|
||
</ul>
|
||
|
||
|
||
</nav>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="o-overlay" aria-hidden="true"></div>
|
||
|
||
<div class="r-breadcrumb">
|
||
|
||
<div id="block-nei-breadcrumbs">
|
||
|
||
|
||
|
||
|
||
|
||
<nav aria-label="Breadcrumb">
|
||
<ol class="c-breadcrumb">
|
||
<li>
|
||
<a href="/espanol">Home</a>
|
||
</li>
|
||
<li>
|
||
CRISPR gene editing promising for blinding disease retinitis pigmentosa
|
||
</li>
|
||
</ol>
|
||
</nav>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="r-page-header">
|
||
<div class="o-page-header">
|
||
|
||
<div id="block-nei-page-title">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<h1>
|
||
<span>CRISPR gene editing promising for blinding disease retinitis pigmentosa</span>
|
||
</h1>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="r-highlighted">
|
||
<div data-drupal-messages-fallback class="hidden"></div>
|
||
|
||
|
||
</div>
|
||
|
||
<div class="r-help">
|
||
|
||
</div>
|
||
<main id="main-content" class="r-main">
|
||
<div class="r-pre-content">
|
||
|
||
</div>
|
||
|
||
<div class="r-splitter">
|
||
<div class="r-content">
|
||
|
||
<div id="block-nei-content">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<article data-history-node-id="4334" lang="en">
|
||
|
||
|
||
|
||
<div>
|
||
|
||
|
||
|
||
|
||
<div class="c-item__subtitle">
|
||
NEI-funded scientists restore key vision protein, retina function and structure
|
||
</div>
|
||
|
||
|
||
<div class="c-item__date">
|
||
November 27, 2024
|
||
</div>
|
||
|
||
|
||
|
||
|
||
<div class="c-item__tag c-item__tag--topic">
|
||
<a href="/about/news-and-events/news?topic=401" hreflang="en">Gene Therapy</a>
|
||
<a href="/about/news-and-events/news?topic=402" hreflang="en">Genetics</a>
|
||
<a href="/about/news-and-events/news?topic=364" hreflang="en">Regenerative Medicine</a>
|
||
<a href="/about/news-and-events/news?topic=7" hreflang="en">Retina</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-item__tag c-item__tag--research-type">
|
||
<a href="/about/news-and-events/news?research=35" hreflang="en">Translational Research</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-item__tag c-item__tag--source">
|
||
<a href="/about/news-and-events/news?source=29" hreflang="en">Grantee</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="c-item__tag c-item__tag--topic">
|
||
<a href="/about/news-and-events/news?initiatives=203" hreflang="en">Audacious Goals Initiative</a>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-news__content">
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>National Eye Institute-funded scientists using gene editing corrected a mutation in a mouse model of retinitis pigmentosa, an inherited blinding eye disorder. The gene editing strategy restored production of rhodopsin, a sensory protein crucial for vision, and led to improvements in retinal function and structure. The findings published online November 18 in the <em>Proceedings of the National Academy of Sciences</em>.</p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
<div class="c-image c-image--has-caption c-image--wide">
|
||
<div class="c-image__src">
|
||
<img src="https://www.nei.nih.gov/sites/default/files/styles/large/public/2024-11/layers%20of%20retina.jpeg?itok=1FKhSLBq" alt="" width="3078" height="2768">
|
||
</div>
|
||
<div class="c-image__caption">
|
||
|
||
|
||
|
||
|
||
<p>Gene editing restored the production of rhodopsin in the photoreceptor outer segments, and preserved the thickness of the outer nuclear layer, where photoreceptor nuclei are located. Credit: Biorender</p>
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div class="c-text">
|
||
|
||
|
||
|
||
|
||
<p>“Further development of this gene editing approach may expand treatment options for patients with inherited retinal diseases caused by mutations in rhodopsin for which there are currently no treatments,” said the study’s lead investigator, Krzysztof Palczewski, Ph.D., Irving H. Leopold Chair of Ophthalmology and distinguished professor, University of California, Irvine School of Medicine. The study was conducted in collaboration with the lab of David R. Liu, Ph.D. at the Broad Institute of MIT and Harvard.</p><p>Vision depends on the function of light-sensitive neurons in the retina called rod and cone photoreceptors. Rods are crucial for night vision; cones are important for daytime vision and perceiving color. Packed into the outer segments of photoreceptor cells are light-sensitive proteins called opsins that capture photons of light and convert them into electrical signals that the brain deciphers as vision.</p><p>Rhodopsin, the type of opsin in rod photoreceptors, also plays a major structural role. In diseases like retinitis pigmentosa, mutations in the genetic instructions for making rhodopsin impair the structure and function of rod photoreceptors, which leads to rod photoreceptor death and vision loss.</p><p>Using a CRISPR-Cas9 tool called base editing, a gene editing strategy capable of precisely targeting and replacing specific DNA sequences, the researchers edited a rhodopsin-150K mutation in a mouse model of retinitis pigmentosa. In people, rhodopsin-150K mutations cause a rare, autosomal recessive form of disease, which is inherited by a child who receives the mutated gene from each parent.</p><p>“The selection of an autosomal recessive form of the disease, we reasoned, would allow us to achieve a therapeutic rescue from reasonably efficient editing. In a clinical setting, correction of even a subset of rod photoreceptors could potentially stop the progression of retinal degeneration and provide some benefit to patients,” said Palczewski.</p><p>The gene editing strategy productively edited up to 44% of the rhodopsin gene product in the treated mice.</p><p>Compared with untreated mice, those treated within 15 days of birth had modest improvements in retinal function, according to electroretinography, which measures photoreceptor responses to light. Mice treated after 15 days were found to have retinal degeneration that was too far gone to be rescued by the gene editing approach.</p><p>The investigators are hopeful they can improve gains in retinal function by optimizing dosing and improving surgical technique, noting in their report that the effect of treatment was uneven across the retina.</p><p>The gene editing treatment also prevented the loss of a retinal tissue layer called the outer nuclear layer, which contains the nuclei of rod and cone photoreceptors.</p><p>The rescue of rod photoreceptors in retinitis pigmentosa is expected to also improve the function of cone photoreceptors, as rods support the health of cones.</p><p>The study was funded by the NEI grants R01EY009339, R01EY034501, F30EY033642, F30EY029136, and P30EY034070.</p><p> </p><p>Reference</p><p>Du SW, Newby GA, Salom D, Gao F, Menezes CR, Suh S, Choi EH, Chen PZ, Liu DR, Palczewski K. “In vivo photoreceptor base editing ameliorates rhodopsin-E150K autosomal-recessive retinitis pigmentosa in mice.” Published online November 18, 2024, PNAS. <a href="https://doi.org/10.1073/pnas.2416827121">https://doi.org/10.1073/pnas.2416827121</a></p>
|
||
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-contact">
|
||
<h2 class="c-contact__heading">Contact</h2>
|
||
<div class="c-contact__label c-contact__name"><strong>Kathryn DeMott</strong></div>
|
||
<div class="c-contact__label c-contact__title">Lead Public Affairs Specialist</div>
|
||
<div class="c-contact__label c-contact__email">
|
||
<a href="mailto:neinews@nei.nih.gov">Email</a>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
|
||
</article>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</div>
|
||
<aside class="r-sidebar" role="complementary">
|
||
|
||
<div class="views-element-container" id="block-views-block-nei-sidebar-block-1">
|
||
|
||
|
||
|
||
|
||
|
||
<div>
|
||
<div class="js-view-dom-id-4129030d1a60887247c21ce4a3e4958f85e2ba5030622108215e764b7aafa9f6 nei-sidebar">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</aside>
|
||
</div>
|
||
</main>
|
||
|
||
<div class="r-footer">
|
||
<footer class="o-footer" role="contentinfo">
|
||
|
||
<div id="block-footer-2">
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
|
||
<div class="o-footer__row">
|
||
<div class="o-footer__group o-footer__group--logo"><a class="o-logo__link" href="/" rel="home" title="Home"><span class="o-logo__text">National Eye Institute</span></a>
|
||
<ul class="o-menu-social">
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--facebook outlink-ignore" href="https://www.facebook.com/NationalEyeInstitute">Facebook</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--twitter outlink-ignore" href="https://twitter.com/NatEyeInstitute">Twitter</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--linkedin outlink-ignore" href="https://www.linkedin.com/company/national-eye-institute-nei">LinkedIn</a></li>
|
||
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--youtube outlink-ignore" href="https://www.youtube.com/user/neinih">YouTube</a></li>
|
||
</ul>
|
||
|
||
<p> </p>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--contact">
|
||
<h2 class="o-footer__title">Contactenos NEI</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/contactenos">Contáctenos</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/about-nih/visitor-information">Visite a los NIH (en inglés)</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://list.nih.gov/cgi-bin/wa.exe?SUBED1=insidenei&A=1">Reciba actualizaciones del NEI a través del correo electrónico (en inglés)</a></li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--policies">
|
||
<h2 class="o-footer__title">Politicas</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/informacion-sobre-accesibilidad">Accesibilidad</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/nondiscrimination-notice-language-assistance-services#spanish">Información en otros idiomas</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/ley-de-libertad-de-informacion-foia">Política de privacidad</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/ley-de-libertad-de-informacion-foia">Ley de Libertad de Información (FOIA)</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/descargo-de-responsabilidades">Descargo de responsabilidades</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/politicas-de-la-pagina-web">Políticas de la página web</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html ">Declaración sobre vulnerabilidad (en inglés)</a></li>
|
||
</ul>
|
||
</div>
|
||
|
||
<div class="o-footer__group o-footer__group--employees">
|
||
<h2 class="o-footer__title">Para los empleados de NEI</h2>
|
||
|
||
<ul class="o-menu-footer">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov">Intranet</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov/hr/Pages/emergency.aspx">Información de emergencia</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://ned.nih.gov/search/search.aspx">Directorio de los funcionarios del NEI</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="o-footer__row">
|
||
<div class="o-footer__full o-footer__full--parent">
|
||
<ul class="o-menu-footer o-menu-footer--swing">
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/">NIH.gov</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://hhs.gov/">HHS.gov</a></li>
|
||
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://usa.gov/">USA.gov</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
|
||
|
||
|
||
</div>
|
||
|
||
|
||
</footer>
|
||
</div>
|
||
|
||
</div>
|
||
|
||
</div>
|
||
|
||
|
||
|
||
<div class="c-lb-wrapper" id="lb-wrapper" aria-hidden="true">
|
||
<div class="c-lb-overlay" tabindex="-1"></div>
|
||
<div role="dialog" class="c-lb" id="lb">
|
||
<div class="c-lb-header">
|
||
<button class="c-lb-close-btn"><span class="c-lb-close-btn-text">Close</span><span class="c-lb-close-btn-text times" aria-hidden="true">×</span></button>
|
||
</div>
|
||
<figure class="c-lb-figure">
|
||
<figcaption class="c-lb-caption"></figcaption>
|
||
</figure>
|
||
</div>
|
||
</div>
|
||
|
||
<script src="/sites/default/files/js/js_P5UBl7ML5jj6dp4P_zp1vfnURYj58JsfQMLHLuwiELA.js?scope=footer&delta=0&language=es&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
||
<script src="/themes/custom/nei/js/scripts.js?sraguf"></script>
|
||
|
||
</body>
|
||
</html>
|