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<meta name="abstract" content="The National Institutes of Health sponsored its first-ever workshop on cerebral visual impairment (CVI), an umbrella term for subnormal vision resulting from brain injury during development. Clinicians, researchers, and stakeholders discussed establishing CVI diagnostic criteria, boosting awareness of CVI, and creating a patient data registry to serve as a platform for data collection and to facilitate research on the brain-based visual disorder." />
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<a href="/espanol" class="o-logo__link" title="Home" rel="home"><span class="o-logo__text">National Eye Institute</span> <span class="o-logo__tagline">Research Today… Vision Tomorrow</span></a>
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Consensus, awareness, and a CVI registry top priorities of the trans-NIH event
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January 9, 2024
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<a href="/about/news-and-events/news?topic=384" hreflang="en">Cerebral Visual Impairment (CVI)</a>
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<p>The National Institutes of Health sponsored its first-ever workshop on cerebral/cortical visual impairment (CVI), an umbrella term for subnormal vision resulting from brain injury during development. Clinicians, researchers, and stakeholders discussed establishing CVI diagnostic criteria, boosting awareness of CVI, and creating a participant data registry to serve as a platform for data collection and to facilitate research on the brain-based visual disorder.</p><p>CVI’s varying symptoms have challenged efforts to define the condition, form diagnostic criteria, and develop treatment. CVI affects vision processing in the brain in ways that cannot be completely explained by problems occurring in the eyes. CVI can manifest as higher-order visual deficits, such as the inability to recognize known objects such as a familiar toy. It can also manifest as lower-order visual deficits, such as reduced contrast sensitivity and limited field of vision; uncontrollable eye movements called saccades; or difficulty tracking moving objects.</p><p>The group drafted a working CVI definition: “CVI is a spectrum of visual impairments caused by an underlying structural and/or functional brain abnormality that affects the development of visual function and processing.” Functional vision refers to a person’s ability to interact with and make sense of the complex visual world around them.</p><p>The workshop covered current strategies for diagnosing CVI and the need for developing and validating evidence-based, age-appropriate tests and intervention protocols for CVI.</p><p>The group discussed boosting awareness of CVI, which is underrecognized and misdiagnosed. A person with CVI can have a completely normal eye exam, leading health professionals to attribute visual symptoms to behavioral disorders. CVI is also often overshadowed by comorbid neurological disorders, such as cerebral palsy or cognitive delay, which may further complicate getting an accurate diagnosis.</p><p>“Although CVI may be co-morbid with other neurodevelopmental disorders, CVI is not primarily a disorder of language, learning, or social communication,” according to drafted criteria.</p><p>Attendees pointed to the need for healthcare provider training programs about CVI, promotion of available CVI screening tools, and sponsorship for public education campaigns.</p><p>Feedback from the workshop will inform the development of a CVI registry that NEI plans to build with the help of a committee. In the future, participant recruitment methods and research protocols for the registry will be identified. One possibility is the use of a global unique identifier system. With it, the CVI registry would connect data from participants across multiple registries to help identify conditions that commonly overlap with CVI. In addition, the CVI registry could potentially track participants over time to study natural history and epidemiology trends.</p><p>The November event was organized by the National Eye Institute, the National Institute on Neurological Disorders and Stroke, and the Eunice Kennedy Shriver Institute of Child Health and Human Development. The event was co-chaired by Lotfi Merabet, O.D., Ph.D., associate professor of ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, and Melinda Chang, M.D., an assistant professor of clinical ophthalmology at the University of Southern California. People with CVI and people who support individuals with CVI, including caregivers and teachers, provided input.</p><p>“Propelling these areas forward will require a multidisciplinary approach involving ophthalmologists, pediatricians, neurologists, imaging experts, occupational therapists, and educators,” said Michael F. Chiang, M.D., director of the NEI, which tagged CVI as a priority area in the 2021 <a href="https://www.nei.nih.gov/sites/default/files/2021-12/NEI-StrategicPlan-VisionForTheFuture_508_edit.pdf">NEI Strategic Plan</a>. “Overall, we need a much better understanding of the neural basis of CVI in order to build a foundation for new therapies.”</p><p class="p2">Watch a videocast of the workshop <a href="https://videocast.nih.gov/watch=52728">at this link</a>. For more information, visit <a href="https://www.nei.nih.gov/learn-about-eye-health/eye-conditions-and-diseases/cerebral-visual-impairment-cvi">this link to the NEI webpage on CVI</a>.</p>
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