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Compelling evidence points to the cytoprotective and proregenerative effects of a neuropeptide in promoting corneal healing after eye injury
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January 2, 2024
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<a href="/about/news-and-events/news?topic=243" hreflang="en">Corneal Conditions</a>
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<a href="/about/news-and-events/news?topic=364" hreflang="en">Regenerative Medicine</a>
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<img src="https://www.nei.nih.gov/sites/default/files/styles/large/public/2024-01/Dana_aMSH_creditAmJPath.jpeg?itok=ylYrKV8C" alt="Schematic showing aMSH effect on corneal wound healing." width="1580" height="886">
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<p>Researchers at Harvard Medical School have demonstrated the potent therapeutic effects of administration of the neuropeptide α-melanocyte–stimulating hormone (α-MSH) through melanocortin receptor agonism, providing compelling evidence for the therapeutic potential of this pathway for a wide array of eye disorders. CEnC, corneal endothelial cells; PBS, phosphate-buffered saline. Image credit: The American Journal of Pathology</p>
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<p>Findings from a pioneering study in The American Journal of Pathology reveal that administration of the neuropeptide α-melanocyte–stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration.</p><p>This study examined the effect of local administration of α-MSH on persistent corneal edema and endothelial regeneration in an established model of injury-induced endothelial decompensation. The results show the impressive therapeutic potential of promoting the melanocortin pathway using α-MSH, thus opening new avenues of therapy.</p>
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