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<p>Researchers from the Department of Ophthalmology, Visual, and Anatomical Sciences at the Wayne State University School of Medicine have identified three non-antibiotic drugs that can protect the eye from severe inflammation during bacterial infection. The drugs can also be used as adjunct therapy with standard antibiotics to minimize infection outcomes.</p>
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<p>Ashok Kumar, Ph.D., at left, and Susmita Das, Ph.D. Credit: Wayne State University.</p>
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<p>The study was led by Ashok Kumar, Ph.D., a principal investigator at Kresge Eye Institute. His laboratory has been involved in investigating host-pathogen interactions and new treatment options in bacterial, viral and fungal eye infection models for several years.</p><p>“One of the ways to identify new drugs for any disease includes drug repurposing, where we can identify additional uses for already-approved drugs, enabling the quickest and cheapest possible transition from bench to bedside,” Dr. Kumar said.</p><p>Susmita Das, Ph.D., a postdoctoral fellow in Dr. Kumar’s laboratory, is the lead author on “Transcriptomics and systems biology identify non-antibiotic drugs for the treatment of ocular bacterial infection,” published in iScience, a Cell Press journal.</p>
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