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<p>University of Pennsylvania researchers have developed a gene therapy that restores dim-light vision in dogs with a congenital form of night blindness, offering hope for treating a similar condition in people.</p>
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<img src="https://www.nei.nih.gov/sites/default/files/styles/small/public/2022-03/vector%20screening%20copy.jpg?itok=nL_AJEme" alt="Stained image of retina" width="492" height="645">
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<p>UPenn researchers used gene therapy to specifically target ON bipolar cells in the middle layer of the retina. (Image: Courtesy of Keiko Miyadera)</p>
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<p>People with congenital stationary night blindness (CSNB) are unable to distinguish objects in dim-light conditions. This impairment presents challenges, especially where artificial lighting is unavailable or when driving at night.</p><p>In 2015, the researchers, from Penn’s School of Veterinary Medicine, learned that dogs could develop a form of inherited night blindness with strong similarities to the condition in people. In 2019, the team identified the gene responsible.</p><p>Today, in the journal Proceedings of the National Academy of Sciences, they’ve reported a major advance: a gene therapy that returns night vision to dogs born with CSNB. The success of this approach, which targets a group of cells deep in the retina called ON bipolar cells, charts a significant step toward a goal of developing a treatment for both dogs and people with this condition, as well as other vision problems that involve ON bipolar cell function.</p>
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<a href="https://penntoday.upenn.edu/news/correcting-night-blindness-dogs" class="c-link__link">Read more at Penn Today</a>
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