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CounterACT Ocular Therapeutics Program
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<h1>
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<span>CounterACT Ocular Therapeutics Program</span>
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</h1>
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<p>The CounterACT Ocular Therapeutics Screening (COTS) program seeks to identify novel ocular therapeutics that may be administered in a civilian first-responder or emergency care setting to effectively suppress and/or mitigate eye pathologies after sulfur mustard (SM) exposure.</p><p>The COTS program supports translational studies evaluating the potential in vivo efficacy of investigational medical countermeasures (MCMs) against eye injuries after exposure to sulfur mustard.</p><p>The primary purpose of the COTS program is to provide investigators with pre-application, pilot proof-of principle efficacy data in support of potential follow-on research efforts.</p><p>Proposed studies may not overlap with, but may be performed in concert with, studies conducted through other Chemical Countermeasures Research Program (CCRP) resources.</p><p>The COTS program does not replace the need to establish direct collaborations with laboratories certified to work with restricted chemical agents in follow-on research efforts.</p><p>Participants will retain custody of and have primary rights to the data developed, subject to government rights of access consistent with current HHS, U.S. Public Health Service, and NIH policies.</p><p>All information provided to the NIH contractor will be treated as confidential.</p><p>Studies are conducted through a NIAID-supported research facility at no cost to the investigator/supplier.</p>
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<h2 class="c-section__heading">
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Eligibility Criteria
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<p>The COTS program is available to all investigators with promising MCMs responsive to the mission of the CCRP.</p><p>NIH will accept applications from individual principal investigators (PIs) from academic institutions, government laboratories, and companies. PIs may consult with NIH to determine eligibility.</p><p>PIs from foreign institutions and non-U.S. components of U.S. organizations are not eligible to apply.</p><p>The supplier of the test compound must provide information regarding its toxicity, solubility, and purity, as well as evidence of ex vivo or in vivo efficacy as a potential ocular therapeutic. This information is required before testing of individual analogs and congeners as well.</p><p>The supplier must be able to provide a sufficient quantity of the compound with ≥ 95% purity (nuclear magnetic resonance [NMR] or high-performance liquid chromatography [HPLC] analysis) for evaluation in up to 15 animals based on the highest median effective dose (ED50) of the previous efficacy studies.</p>
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<h2 class="c-section__heading">
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Screening Model
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<p>The COTS program employs an in vivo screening model in animals to determine the efficacy of investigational compounds in mitigating SM-induced ocular damage. Investigators may propose up to two therapeutic regimens for evaluation. NIH will deliver a final study report to the investigator at the end of the study.</p><p>Upon request prior to study start, eyes (with optic nerve) may be provided as a resource to the applicant for further evaluation.</p>
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</div>
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<div class="c-section" id="section-id-18115">
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Resources
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</h2>
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<div class="c-link">
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<a href="https://www.ninds.nih.gov/Current-Research/Trans-Agency-Activities/CounterACT/Researchers-Projects" class="c-link__link">Currently Funded Ocular Chemical Injury Projects</a>
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</div>
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<div class="c-link">
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<a href="https://www.niaid.nih.gov/research/chemical-countermeasures-program" class="c-link__link">NIAID Chemical Countermeasures Research Program (CCRP)</a>
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</div>
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<div class="c-link">
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<a href="https://www.ninds.nih.gov/Current-Research/Trans-Agency-Activities/CounterACT/Scientific-Research-Contacts" class="c-link__link">NINDS CounterACT Program </a>
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</div>
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</div>
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<div class="c-section" id="section-id-18117">
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Program Director
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<div class="c-text">
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<p>If you're interested in more information, including apply to the COTS program, contact:</p><p><strong>Director of Lens and Cataract Program</strong><br>Houmam Araj, PhD<br><a href="mailto:Houmam.Araj@nih.gov">Houmam.Araj@nih.gov</a></p>
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</article>
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<p class="views-element-container c-last-updated" id="block-views-block-nei-last-updated-block-1"><strong>Actualización más reciente:</strong> 8 de enero de 2025</p>
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