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Case Western Reserve University researchers use lipids to safely deliver gene therapy to the eye, successfully holding off advance of rare, inherited eye disorder
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March 6, 2020
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<a href="/about/news-and-events/news?topic=401" hreflang="en">Gene Therapy</a>
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<a href="/about/news-and-events/news?topic=402" hreflang="en">Genetics</a>
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<a href="/about/news-and-events/news?topic=364" hreflang="en">Regenerative Medicine</a>
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<a href="/about/news-and-events/news?topic=151" hreflang="en">Stargardt Disease</a>
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<img src="https://www.nei.nih.gov/sites/default/files/styles/small/public/2020-03/Zheng-Rong%20Lu-.jpg?itok=0OsrPFoq" alt="Zheng-Rong Lu" width="212" height="265">
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<p>Zheng-Rong Lu. Credit Case Western Reserve University.</p>
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<p>Researchers at Case Western Reserve University have used a unique method to safely deliver gene therapy to fight a rare, but irreversible, genetic eye disorder known as <a href="/learn-about-eye-health/eye-conditions-and-diseases/stargardt-disease">Stargardt disease</a>.</p><p>By using chemically modified lipids—instead of the viruses most commonly used as carriers—Stargardt disease did not return in animal models for up to eight months after treatment, said lead researcher <a href="https://case.edu/medicine/ccir/faculty/zheng-rong-lu">Zheng-Rong Lu,</a> the M. Frank Rudy and Margaret Domiter Rudy Professor of Biomedical Engineering at the Case School of Engineering, with a dual appointment at the School of Medicine.</p>
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