694 lines
31 KiB
Text
694 lines
31 KiB
Text
|
|
<!DOCTYPE html>
|
|
<html lang="es" dir="ltr">
|
|
<head>
|
|
<meta charset="utf-8" />
|
|
<meta name="description" content="The Experimental Immunology Section of the NEI Laboratory of Immunology addresses issues related to mechanisms, cells, and molecules that participate in the induction or modulation of ocular inflammation. Learn more about the lab, its key staff, and browse publications." />
|
|
<meta name="google" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw,lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
|
<meta name="google-site-verification" content="vityevxlt8UuVFWvgz9_YwmJ5F0Nby_B3t54LLh-3Zw" />
|
|
<meta name="google-site-verification" content="lACaj571Gx_VdLF3HKSKUf1Wxx0H_bWxO3BYDZ_C1uw" />
|
|
<meta name="google-site-verification" content="UDfyeEAWNX_rJUHwog9j1kziEnByGwhkSJGLJclUWDA" />
|
|
<meta name="viewport" content="width=device-width, initial-scale=1.0" />
|
|
<script type="application/ld+json">{
|
|
"@context": "https://schema.org",
|
|
"@graph": [
|
|
{
|
|
"@type": "WebPage",
|
|
"@id": "https://www.nei.nih.gov/research/research-labs-and-branches/experimental-immunology-section",
|
|
"breadcrumb": {
|
|
"@type": "BreadcrumbList",
|
|
"itemListElement": [
|
|
{
|
|
"@type": "ListItem",
|
|
"position": 1,
|
|
"name": "Home",
|
|
"item": "https://www.nei.nih.gov/espanol"
|
|
},
|
|
{
|
|
"@type": "ListItem",
|
|
"position": 2,
|
|
"name": "Experimental Immunology Section",
|
|
"item": "https://www.nei.nih.gov/espanol/node/208"
|
|
}
|
|
]
|
|
},
|
|
"author": {
|
|
"@type": "GovernmentOrganization",
|
|
"@id": "https://www.nei.nih.gov",
|
|
"name": "National Eye Institute",
|
|
"url": "https://www.nei.nih.gov"
|
|
},
|
|
"publisher": {
|
|
"@type": "GovernmentOrganization",
|
|
"@id": "https://www.nei.nih.gov",
|
|
"name": "National Eye Institute",
|
|
"url": "https://www.nei.nih.gov"
|
|
}
|
|
}
|
|
]
|
|
}</script>
|
|
<link rel="icon" type="image/png" href="/themes/custom/nei/images/favicon.png" />
|
|
<link rel="apple-touch-icon" href="/themes/custom/nei/images/apple-touch-icon.png" />
|
|
<meta name="last-updated" content="Nov 25, 2024, 3:55:04 PM" />
|
|
<link rel="icon" href="/themes/custom/nei/favicon.ico" type="image/vnd.microsoft.icon" />
|
|
<link rel="alternate" hreflang="en" href="https://www.nei.nih.gov/research/research-labs-and-branches/experimental-immunology-section" />
|
|
<link rel="canonical" href="https://www.nei.nih.gov/research/research-labs-and-branches/experimental-immunology-section" />
|
|
<link rel="shortlink" href="https://www.nei.nih.gov/node/208" />
|
|
|
|
<title>Experimental Immunology Section | National Eye Institute</title>
|
|
<link rel="preload" href="/themes/custom/nei/fonts/Aleo-Bold.woff2" as="font" type="font/woff2" crossorigin>
|
|
<link rel="preload" href="/themes/custom/nei/fonts/Lato-Regular.woff2" as="font" type="font/woff2" crossorigin>
|
|
<link rel="stylesheet" media="all" href="/sites/default/files/css/css_PGSk_7b88hq2qr_--_38MLvoj1ffr9jv3JhnNJTnKUM.css?delta=0&language=es&theme=nei&include=eJw1ytEKgCAMRuEXsnwk-dMxrOliTqi3j4iuDnycfFCprpbyHK4tDb-FRvwSshrFYvOErNhxBUHnCaYEcbJ_61Qji26Q5ZXa-QH_YCJ9" />
|
|
<link rel="stylesheet" media="all" href="/themes/custom/nei/css/style.css?sraguf" />
|
|
|
|
<script type="application/json" data-drupal-selector="drupal-settings-json">{"path":{"baseUrl":"\/","pathPrefix":"espanol\/","currentPath":"node\/208","currentPathIsAdmin":false,"isFront":false,"currentLanguage":"es"},"pluralDelimiter":"\u0003","gtag":{"tagId":"","consentMode":false,"otherIds":[],"events":[],"additionalConfigInfo":[]},"suppressDeprecationErrors":true,"ajaxPageState":{"libraries":"eJxdjFsOwjAMBC8U6iNFbmKZgPNQ7BTK6SmgCsrPrndkTbhSTFa7D0OtZq-2Cil8yoWOj5WYYT8c18pC3pCBt_jfE17wfoTZCRYeyORRjPruLmhpIS-b2EvFmArD73CFErDUGeWkoadmekCb5fXVsCN3bGeF2EdDmb5kGqWNWZKeKTpd1SjDjEpuSXRTeOeUaxxCT9WYZ50","theme":"nei","theme_token":null},"ajaxTrustedUrl":{"form_action_p_pvdeGsVG5zNF_XLGPTvYSKCf43t8qZYSwcfZl2uzM":true},"gtm":{"tagId":null,"settings":{"data_layer":"dataLayer","include_classes":false,"allowlist_classes":"google\nnonGooglePixels\nnonGoogleScripts\nnonGoogleIframes","blocklist_classes":"customScripts\ncustomPixels","include_environment":false,"environment_id":"","environment_token":""},"tagIds":["GTM-TLVNS7W"]},"user":{"uid":0,"permissionsHash":"c48594e108b5c1c2bea409821b71477d5bc2724c8cae6d31f1d985af0daab85c"}}</script>
|
|
<script src="/sites/default/files/js/js_WgzMsgqb-MiW-Z2aLffGQHepZwX2hWrEHSrb46WqZrk.js?scope=header&delta=0&language=es&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
|
<script src="https://script.crazyegg.com/pages/scripts/0117/6571.js" async></script>
|
|
<script src="/modules/contrib/google_tag/js/gtag.js?sraguf"></script>
|
|
<script src="/modules/contrib/google_tag/js/gtm.js?sraguf"></script>
|
|
|
|
</head>
|
|
<body class="t-lab_page t-node__208 path-node-208">
|
|
<a href="#main-content" class="u-skip-link">
|
|
Skip to content
|
|
</a>
|
|
<noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-TLVNS7W"
|
|
height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
|
|
|
|
<div class="dialog-off-canvas-main-canvas" data-off-canvas-main-canvas>
|
|
|
|
<div id="u-page-outer" class="u-outer">
|
|
<div class="views-element-container site-notice-block" id="block-views-block-site-notices-block-1">
|
|
|
|
|
|
|
|
|
|
|
|
<div>
|
|
<div class="js-view-dom-id-0ad8bc2e426a8b1cafef8a2990c96d7d973a7a2e7a770918fcf24ec9352cfecc site-notices">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
<img src="/themes/custom/nei/images/NEI-logo-tagline.svg" alt="" width="200" height="48" class="u-print-only">
|
|
<div class="r-global-header">
|
|
<div id="r-header-outer" class="r-header">
|
|
|
|
<div class="r-header-inner">
|
|
|
|
<div id="block-nei-branding" class="o-block--logo" role="banner">
|
|
|
|
|
|
|
|
|
|
|
|
<div class="o-logo">
|
|
<a href="/espanol" class="o-logo__link" title="Home" rel="home"><span class="o-logo__text">National Eye Institute</span> <span class="o-logo__tagline">Research Today… Vision Tomorrow</span></a>
|
|
</div>
|
|
|
|
|
|
</div>
|
|
|
|
<div id="block-neimenubutton-2">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<div class="o-menu-toggle"><button class="o-menu-toggle__btn" id="menu-toggle__btn" aria-controls="block-mainnavigation" aria-expanded="true">Menú</button></div>
|
|
|
|
|
|
|
|
|
|
</div>
|
|
<div class="language-switcher-language-url has-no-translation" id="block-languageswitcher" role="navigation" aria-label="Language switcher">
|
|
|
|
|
|
<ul class="links">
|
|
<li>
|
|
<a href="/research/research-labs-and-branches/experimental-immunology-section" class="language-link is-active" lang="en" data-drupal-link-system-path="node/208" aria-current="page">English</a>
|
|
</li>
|
|
<li class="is-active">
|
|
<a href="/espanol/node/208" class="language-link is-active" lang="es" data-drupal-link-system-path="node/208" aria-current="page"> Español</a>
|
|
</li>
|
|
</ul>
|
|
|
|
|
|
</div>
|
|
<div class="search-global c-search--global" data-drupal-selector="search-global" id="block-globalsearchform" role="search">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<form action="/espanol/node/208" method="post" id="search-global" accept-charset="UTF-8">
|
|
<div class="c-form__inner">
|
|
<div class="js-form-item form-item js-form-type-textfield form-item-global-terms js-form-item-global-terms">
|
|
<label for="edit-global-terms">Buscar en la página</label>
|
|
<input data-drupal-selector="edit-global-terms" type="text" id="edit-global-terms" name="global-terms" value="" size="30" maxlength="128" placeholder="Buscar en la página" class="form-text" />
|
|
|
|
</div>
|
|
<input data-drupal-selector="form-hqb0di9mv-8xolxil3sxf-up2xxz2d-fgiz1mazet0q" type="hidden" name="form_build_id" value="form-hQB0Di9mv_8xolXIL3sXF-uP2XXZ2d-FGIz1maZeT0Q" />
|
|
<input data-drupal-selector="edit-search-global" type="hidden" name="form_id" value="search_global" />
|
|
<div data-drupal-selector="edit-global-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-global-actions"><input data-drupal-selector="edit-global-submit" type="submit" id="edit-global-submit" name="op" value="Buscar" class="button js-form-submit form-submit" />
|
|
</div>
|
|
|
|
</div>
|
|
</form>
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
|
|
</div>
|
|
|
|
</div>
|
|
|
|
<div class="r-menu-primary">
|
|
<nav aria-label="Main navigation" id="block-mainnavigation" class="o-menu-main__outer">
|
|
|
|
<ul class="o-menu o-menu-main"> <li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/espanol/aprenda-sobre-la-salud-ocular" class="o-menu-main__link" data-drupal-link-system-path="node/39">Aprenda sobre la salud ocular</a>
|
|
<ul class="o-menu o-menu-main__submenu"> <li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/vision-saludable" class="o-menu-main__link" data-drupal-link-system-path="node/788">Visión saludable</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/enfermedades-y-afecciones-de-los-ojos" class="o-menu-main__link" data-drupal-link-system-path="learn-about-eye-health/eye-conditions-and-diseases">Enfermedades y afecciones de los ojos</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/datos-y-estadisticas-relacionadas-con-la-salud-ocular" class="o-menu-main__link" data-drupal-link-system-path="node/825">Datos y estadísticas relacionadas con la salud ocular</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/espanol/aprenda-sobre-la-salud-ocular/rehabilitacion-visual" class="o-menu-main__link" data-drupal-link-system-path="node/3865">Rehabilitación visual</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/aprenda-sobre-la-salud-ocular/campanas-de-difusion-y-recursos" class="o-menu-main__link" data-drupal-link-system-path="node/125">Campañas de difusión y recursos</a>
|
|
</li>
|
|
</ul>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--expanded o-menu-main__item--no-js"> <a href="/espanol/acerca-del-NEI" class="o-menu-main__link" data-drupal-link-system-path="node/275">Acerca del Instituto Nacional del Ojo</a>
|
|
<ul class="o-menu-main__submenu o-menu"> <li class="o-menu-main__item"> <a href="/espanol/acerca-del-NEI/planificacion-estrategica-en-el-nei" class="o-menu-main__link" data-drupal-link-system-path="node/2857">Planificación estratégica en el NEI</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/metas-y-logros" class="o-menu-main__link" data-drupal-link-system-path="node/281">Metas y logros</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/historia-del-nei" class="o-menu-main__link" data-drupal-link-system-path="node/282">Historia del NEI</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/lideres-del-instituto-nacional-del-ojo-nei" class="o-menu-main__link" data-drupal-link-system-path="node/415">Líderes del Instituto Nacional del Ojo (NEI)</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/el-presupuesto-y-el-congreso" class="o-menu-main__link" data-drupal-link-system-path="node/395">El presupuesto y el Congreso</a>
|
|
</li>
|
|
<li class="o-menu-main__item o-menu-main__item--collapsed"> <a href="/espanol/acerca-del-NEI/comites-asesores" class="o-menu-main__link" data-drupal-link-system-path="node/285">Comités asesores</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/espanol/aprenda-sobre-la-salud-ocular/campanas-de-difusion-y-recursos/programa-nacional-de-educacion-sobre-la-salud-del-ojo" title="National Eye Health Education Program" class="o-menu-main__link" data-drupal-link-system-path="node/265">Programa Nacional de Educación sobre la Salud del Ojo</a>
|
|
</li>
|
|
<li class="o-menu-main__item"> <a href="/espanol/acerca-del-NEI/done-al-instituto-nacional-del-ojo-nei" class="o-menu-main__link" data-drupal-link-system-path="node/286">Done al Instituto Nacional del Ojo (NEI)</a>
|
|
</li>
|
|
</ul>
|
|
</li>
|
|
</ul>
|
|
|
|
|
|
</nav>
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
<div class="o-overlay" aria-hidden="true"></div>
|
|
|
|
<div class="r-breadcrumb">
|
|
|
|
<div id="block-nei-breadcrumbs">
|
|
|
|
|
|
|
|
|
|
|
|
<nav aria-label="Breadcrumb">
|
|
<ol class="c-breadcrumb">
|
|
<li>
|
|
<a href="/espanol">Home</a>
|
|
</li>
|
|
<li>
|
|
Experimental Immunology Section
|
|
</li>
|
|
</ol>
|
|
</nav>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<div class="r-page-header">
|
|
<div class="o-page-header">
|
|
|
|
<div id="block-nei-page-title">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<h1>
|
|
<span>Experimental Immunology Section</span>
|
|
</h1>
|
|
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
<div class="r-highlighted">
|
|
<div data-drupal-messages-fallback class="hidden"></div>
|
|
|
|
|
|
</div>
|
|
|
|
<div class="r-help">
|
|
|
|
</div>
|
|
<main id="main-content" class="r-main">
|
|
<div class="r-pre-content">
|
|
|
|
</div>
|
|
|
|
<div class="r-splitter">
|
|
<div class="r-content">
|
|
|
|
<div id="block-nei-content">
|
|
|
|
|
|
|
|
|
|
|
|
<article data-history-node-id="208" lang="en">
|
|
<div>
|
|
<div class="r-content">
|
|
|
|
|
|
<div class="c-section">
|
|
<h2>About our work</h2>
|
|
<div>
|
|
<div><div class="c-text">
|
|
|
|
|
|
|
|
|
|
<p>The research carried out by the Section addresses issues related to mechanisms, cells and molecules that participate in the induction or modulation of ocular inflammation. We are using the following animal models for ocular inflammation: (i) experimental autoimmune uveitis (EAU), that is actively induced in rodents by immunization with retinal antigens, mostly IRBP or S-antigen, or uveitogenic peptides from their sequence; (ii) ocular inflammation that is induced in transgenic mice expressing hen egg lysozyme (HEL) in their eyes, by adoptively transferring populations of T-cells specific against HEL. The scientific issues currently being addressed include: (1) mechanisms whereby naïve T-cells are activated to acquire pathogenic capacity and the role played by microbial products in these processes; (2) the pathogenic capacity of Th17 cells and their involvement in inflammatory eye disease; (3) differences between the kinetics of pathogenic processes mediated by Th1 or Th17 cells; (4) plasticity of T-cell subsets; (5) subpopulations of Th17 differing in their pathogenic capacity and other biological features; (6) generation of “Th9” populations and analysis of their unique features; (7) modulation of ocular inflammation by immunosuppressive compounds.</p>
|
|
|
|
|
|
</div>
|
|
</div>
|
|
<div>
|
|
|
|
<div class="c-section" id="section-id-12569">
|
|
<h2 class="c-section__heading">
|
|
|
|
|
|
|
|
|
|
Our research mission
|
|
|
|
|
|
</h2>
|
|
|
|
|
|
|
|
|
|
<div class="c-text">
|
|
|
|
|
|
|
|
|
|
<p>The research carried out by the Section addresses issues related to mechanisms, cells and molecules that participate in the induction or modulation of ocular inflammation.</p><p><em><strong>No longer accepting new fellows/trainees.</strong></em></p>
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
</div>
|
|
</div>
|
|
|
|
|
|
<div class="c-section">
|
|
<h2>Selected publications</h2>
|
|
<div>
|
|
<div><div class="c-text">
|
|
|
|
|
|
|
|
|
|
<p>Hinshaw, S.J.H., Ogbeifun, O., Wandu, W. S., Lyu, C., Shi, G., Li, Y., Qian, H., Gery, I. <a href="https://pubmed.ncbi.nlm.nih.gov/27028065/">Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration.</a> <em>Invest. Ophthalmol. Vis. Sci.</em> March 2016, Vol.57, 1441-1447.</p><p>Wandu, S,W., Tan, C., Ogbeifun, O., Vistica, B.P., Shi, G., Hinshaw, S.J.H., Xie, C., Chen, X., Klinman, D.M., Cai, H., Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/26067490/">Leucine-rich repeat kinase 2 (LRRK2) deficiency diminishes the development of experimental autoimmune uveitis (EAU) and the adaptive immune response.</a> <em>PLoS ONE</em>, 10(6): e0128906. 2015. doi:10.1371/journal. Pone.0128906.</p><p>Shi, G.,Chen, S., Wandu, W.S., Ogbeifun, O., Nugent, L.F., Maminishkis, A, Hinshaw, S.J.H., <a href="https://pubmed.ncbi.nlm.nih.gov/25678688/">Rodriguez, I.R. Gery. I.: Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1and IL-18.</a> <em>Inveset. Ophthalmol. Vis. Sci.</em> 56: 1658-1664, 2015.</p><p>Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/25506345/">The definition of lymphocyte activating factor: giving a helping hand to serendipity. Front. Immunol. </a>5:610, 2014. (doi: 10.3389/fimmu.2014.00610)</p><p>Zhao, C., Shi, G., Vistica, B., Tan, C., Zhang, M., Gery, I.:<a href="https://pubmed.ncbi.nlm.nih.gov/25038545/"> Induced Regulatory T-cells (iTregs) Generated by Activation with Anti-CD3/CD28 Antibodies Differ From Those Generated by The Physiological-like Activation with Antigen/APC</a>. <em>Cellular Immunology</em>, 290:179-184, 2014. Aug;290(2):179-84. doi: 10.1016/j.cellimm.2014.06.004)</p><p>Tan, C., Wei, L., Vistica, B.P., Shi, G., Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/24583715/">Phenotypes of Th lineages generated by the commonly used activation with anti-CD3/CD28 antibodies differ from those generated by the physiological activation with the specific antigen.</a> <em>Cellular & Molecular Immunology</em>, 11:305-313, 2014.</p><p>Nugent, L.F., Shi, G, Vistica, B.P., Ogbeifun, O., Hinshaw, S.J.H., Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/24150760/">ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell mediated immunity. </a><em>Invest Ophthalmol. Vis. Sci.</em>, 54:7463-7469, 2013.</p><p>Montalvo, V., Quigley, L., Vistica, B.P., Boelte, K.C., Nugent, L.F., Takai, T., McVicar, D.W., Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/23906311/">Environmental Factors Determine DAP12 Deficiency To Either Enhance or Suppress Immunopathogenic Processes.</a> <em>Immunology</em>, 140:475-482, 2013.</p><p>Shi, G., Vistica, B.P., Nugent, L.F., Tan, C, Wawrousek, E.F., Klinman, D.M., Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/23720812/">Differential Involvement of Th1 and Th17 in Pathogenic Autoimmune Processes Triggered by Different TLR Ligands.</a> <em>J. Immunol.</em>, 191:415-423, 2013.</p><p>Vistica, B.P., Shi, G., Nugent, L., Tan, C., Altman. A., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/22815639/">SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU).</a> <em>Molecular Vision</em>, 18:1858-1864, 2012. PMC 3398495</p><p>Shi, G. Lovaas, J.D., Tan, C., Vistica, B.P., Wawrousek, E.F., Aziz, M.K., Rigden, R.C., Caspi, R.R., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/22745380/">Cell-cell interaction with APC, not IL-23, is required for naive CD cells to acquire pathogenicity during Th17 lineage commitment.</a> <em>J. Immunol</em>. 189:1220-1227, 2012. PMC 3401365</p><p>Tan, C., Ramaswamy, M, Shi, G., Vistica, B.P., Siegel, R.M. and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/21903206/">Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules.</a> (Rapid Communication) <em>Cell. Immunol</em>. 271:210-213, 2011. PMC 3249224</p><p>Tan, C., Aziz, M.K., Lovaas, J.D., Vistica, B.P., Shi, G., Wawrousek, E.F., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/20971929/">Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.</a> <em>J. Immunol</em>. 185:6795-6801, 2010. PMC 2988091</p><p>Shi, G., Ramaswamy, M., Vistica, B.P., Cox, C.A., Tan, C., Wawrousek, E. F., Siegel, R.M., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/19890052/">Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death.</a> <em>J. Immunol</em>. 183:7547-7556, 2009. PMC 2958176</p><p>Montalvo, V., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/19373582/">Constitutive pro-apoptotic molecules are differentially expressed in the fetal and adult mouse eye.</a> <em>Curr. Eye Res.</em>, 34:328-332, 2009. PMC 2671852</p><p>Fujimoto, C., Klinman, D.M., Shi, G., Yin, H., Vistica, B.P., Lovaas, J.D., Wawrousek, E.F., Igarashi, T., Chan, C.-C., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/19438607/">A suppressive oligodeoxynucleotide inhibits ocular inflammation.</a> <em>Clin. Exp. Immunol</em>. 156:528-534, 2009. PMC 2691983</p><p>Yin, H., Vistica, B.P., Chan, C.-C., Strominger, J.L., and Gery, I.:<a href="https://pubmed.ncbi.nlm.nih.gov/19748134/"> Inhibition of experimental autoimmune uveitis by amino acid copolymers.</a> <em>J. Neuroimmunol</em>. 215:43-48, 2009. PMC 2928056</p><p>Cox, C.A., Shi, G., Yin, H., Vistica, B.P., Wawrousek, E.F., Chan, C.-C., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/19748134/">Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.</a> <em>J. Immunol.</em>, 180:7414-7422, 2008.</p><p>Shi, G., Cox, C.A., Vistica, B.P., Tan, C., Wawrousek, E.F., and Gery, I.: <a href="https://pubmed.ncbi.nlm.nih.gov/18981142/">Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells.</a> <em>J. Immunol.</em>, 181:7205-7213, 2008. PMC 2665021</p>
|
|
|
|
|
|
</div>
|
|
</div>
|
|
</div>
|
|
</div>
|
|
|
|
</div>
|
|
</div>
|
|
|
|
<div class="c-group__staff-list c-section" id="key-staff">
|
|
<h2>Experimental Immunology Section key staff</h2>
|
|
<div class="views-element-container">
|
|
<div class="js-view-dom-id-5c3474a022ed000cdaf8b2d7a7d22de1e2e9c4cdb50a297fd76027546563e34c lab-staff">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
</div>
|
|
|
|
<div class="c-group__staff-list c-section" id="alumni-staff">
|
|
<div class="views-element-container">
|
|
<div class="js-view-dom-id-2a9ccb1925b6f96fa2ab1e473e4596cde57e98b3efe2827dfd96ba53a31aae07 lab-alumni">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
</div>
|
|
|
|
</article>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
<div class="views-element-container" id="block-views-block-news-page-block-5">
|
|
|
|
|
|
|
|
|
|
|
|
<div>
|
|
|
|
<div class="c-filter js-view-dom-id-1bc6bd943180eeefe3827a323a4ee027806cf95a4d869c19523651bbd26eb851 news-page news-page--block_5">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<div id="block-researchatnei" class="c-callout c-callout--wide c-callout--rounded">
|
|
<figure class="c-callout__image">
|
|
<img src="/sites/default/files/styles/400px_square_crop/public/2019-04/shutterstock_605501567_333.jpg?itok=yofmpBZG" alt="">
|
|
</figure>
|
|
<div class="c-callout__content">
|
|
<h2 class="c-callout__heading">Research at NEI</h2>
|
|
|
|
|
|
|
|
|
|
<ul><li><a href="/research/research-labs-and-branches">Research Labs and Branches</a></li><li><a href="/research/research-labs-and-branches/we-are-nei-intramural">Principal Investigators</a></li><li><a href="/grants-and-training/training-nei">Training at NEI</a></li><li><a href="/about/news-and-events/news">Research News</a></li></ul>
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
<p class="views-element-container c-last-updated" id="block-views-block-nei-last-updated-block-1"><strong>Actualización más reciente:</strong> 25 de noviembre de 2024</p>
|
|
|
|
|
|
</div>
|
|
<aside class="r-sidebar" role="complementary">
|
|
<div class="c-sidebar-widget">
|
|
<div class="c-chief">
|
|
<div class="c-chief__upper">
|
|
<div class="views-element-container">
|
|
<div class="o-table--sortable js-view-dom-id-0cd1776e2bff1cbb723ff63da50502446c3cf849b90f74018b75425832f4d1d2 lab-staff">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
</div>
|
|
</div>
|
|
<div class="c-sidebar-widget__contact-information">
|
|
<div class="c-sidebar-widget__header">
|
|
<h2 class="c-sidebar-widget__title">Contact <span>Information</span></h2>
|
|
</div>
|
|
<div class="views-element-container">
|
|
<div class="js-view-dom-id-43c77165190475edc36881c18b9b0be44961b7cd1e60e568ee10fadf595630b1 sidebar-address-labs">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<div>
|
|
<div class="c-sidebar-widget__contact-name">
|
|
|
|
<span>Experimental Immunology Section</span>
|
|
|
|
</div>
|
|
|
|
<div class="c-sidebar-widget__contact-address">
|
|
10 Center Drive<br>
|
|
|
|
|
|
|
|
|
|
Building 10, Room 10N208
|
|
|
|
<br>
|
|
Bethesda,
|
|
Maryland
|
|
20892
|
|
</div>
|
|
|
|
<div class="c-sidebar-widget__contact-phone-fax">
|
|
|
|
|
|
<div>
|
|
<div><span>Phone:</span> 301-496-4159</div>
|
|
</div>
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
</div>
|
|
|
|
<div class="c-sidebar-widget__contact-additional-info">
|
|
<a href="#key-staff" class="c-link__link">See additional lab contact information</a>
|
|
</div>
|
|
</div>
|
|
</div>
|
|
</aside>
|
|
</div>
|
|
</main>
|
|
|
|
<div class="r-footer">
|
|
<footer class="o-footer" role="contentinfo">
|
|
|
|
<div id="block-footer-2">
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
<div class="o-footer__row">
|
|
<div class="o-footer__group o-footer__group--logo"><a class="o-logo__link" href="/" rel="home" title="Home"><span class="o-logo__text">National Eye Institute</span></a>
|
|
<ul class="o-menu-social">
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--facebook outlink-ignore" href="https://www.facebook.com/NationalEyeInstitute">Facebook</a></li>
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--twitter outlink-ignore" href="https://twitter.com/NatEyeInstitute">Twitter</a></li>
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--linkedin outlink-ignore" href="https://www.linkedin.com/company/national-eye-institute-nei">LinkedIn</a></li>
|
|
<li class="o-menu-social__item"><a class="o-menu-social__link o-menu-social__link--youtube outlink-ignore" href="https://www.youtube.com/user/neinih">YouTube</a></li>
|
|
</ul>
|
|
|
|
<p> </p>
|
|
</div>
|
|
|
|
<div class="o-footer__group o-footer__group--contact">
|
|
<h2 class="o-footer__title">Contactenos NEI</h2>
|
|
|
|
<ul class="o-menu-footer">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/contactenos">Contáctenos</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/about-nih/visitor-information">Visite a los NIH (en inglés)</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://list.nih.gov/cgi-bin/wa.exe?SUBED1=insidenei&A=1">Reciba actualizaciones del NEI a través del correo electrónico (en inglés)</a></li>
|
|
</ul>
|
|
</div>
|
|
|
|
<div class="o-footer__group o-footer__group--policies">
|
|
<h2 class="o-footer__title">Politicas</h2>
|
|
|
|
<ul class="o-menu-footer">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/informacion-sobre-accesibilidad">Accesibilidad</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/nondiscrimination-notice-language-assistance-services#spanish">Información en otros idiomas</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/ley-de-libertad-de-informacion-foia">Política de privacidad</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/ley-de-libertad-de-informacion-foia">Ley de Libertad de Información (FOIA)</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/descargo-de-responsabilidades">Descargo de responsabilidades</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="/espanol/politicas-de-la-pagina-web">Políticas de la página web</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html ">Declaración sobre vulnerabilidad (en inglés)</a></li>
|
|
</ul>
|
|
</div>
|
|
|
|
<div class="o-footer__group o-footer__group--employees">
|
|
<h2 class="o-footer__title">Para los empleados de NEI</h2>
|
|
|
|
<ul class="o-menu-footer">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov">Intranet</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://intranet.nei.nih.gov/hr/Pages/emergency.aspx">Información de emergencia</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://ned.nih.gov/search/search.aspx">Directorio de los funcionarios del NEI</a></li>
|
|
</ul>
|
|
</div>
|
|
</div>
|
|
|
|
<div class="o-footer__row">
|
|
<div class="o-footer__full o-footer__full--parent">
|
|
<ul class="o-menu-footer o-menu-footer--swing">
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://www.nih.gov/">NIH.gov</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://hhs.gov/">HHS.gov</a></li>
|
|
<li class="o-menu-footer__item"><a class="o-menu-footer__link" href="https://usa.gov/">USA.gov</a></li>
|
|
</ul>
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
|
|
</div>
|
|
|
|
|
|
</footer>
|
|
</div>
|
|
|
|
</div>
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<div class="c-lb-wrapper" id="lb-wrapper" aria-hidden="true">
|
|
<div class="c-lb-overlay" tabindex="-1"></div>
|
|
<div role="dialog" class="c-lb" id="lb">
|
|
<div class="c-lb-header">
|
|
<button class="c-lb-close-btn"><span class="c-lb-close-btn-text">Close</span><span class="c-lb-close-btn-text times" aria-hidden="true">×</span></button>
|
|
</div>
|
|
<figure class="c-lb-figure">
|
|
<figcaption class="c-lb-caption"></figcaption>
|
|
</figure>
|
|
</div>
|
|
</div>
|
|
|
|
<script src="/sites/default/files/js/js_P5UBl7ML5jj6dp4P_zp1vfnURYj58JsfQMLHLuwiELA.js?scope=footer&delta=0&language=es&theme=nei&include=eJxdjEEOgCAMBD-E9kmkYrOpqdQAMerr5eBBvUx29jCp8HUKQOkZAe4wiY1B6Pj7yAsf33MNmZvuEq0nojnPmkFvCVmUYD6xDTUV3Vq9ATUbLxk"></script>
|
|
<script src="/themes/custom/nei/js/scripts.js?sraguf"></script>
|
|
|
|
</body>
|
|
</html>
|