nih-gov/www.ncbi.nlm.nih.gov/tools/treeviewer/biotreecontainer/index.html

691 lines
35 KiB
HTML
Raw Permalink Blame History

This file contains invisible Unicode characters

This file contains invisible Unicode characters that are indistinguishable to humans but may be processed differently by a computer. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.

This file contains Unicode characters that might be confused with other characters. If you think that this is intentional, you can safely ignore this warning. Use the Escape button to reveal them.

<?xml version="1.0" encoding="utf-8"?>
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
<head>
<!-- AppResources meta begin -->
<meta name="paf-app-resources" content="" />
<!-- AppResources meta end -->
<!-- TemplateResources meta begin -->
<meta name="paf_template" content="StdNCol" />
<!-- TemplateResources meta end -->
<!-- Page meta begin -->
<!-- Page meta end -->
<!-- Logger begin -->
<meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_app" content="treeviewer" /><meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_pdid" content="static" />
<!-- Logger end -->
<title>BioTreeContainer</title>
<!-- PageFixtures headcontent begin -->
<meta name="cms-local-nav-url" content="https://cms.ncbi.nlm.nih.gov//treeviewer/_nav" />
<!-- PageFixtures headcontent end -->
<!-- AppResources external_resources begin -->
<script type="text/javascript" src="/core/jig/1.14.8/js/jig.min.js"></script>
<!-- AppResources external_resources end -->
<!-- Page headcontent begin -->
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
<meta name="created" content="2014-04-23T13:30:54-04:00" />
<meta name="modified" content="2017-03-10T16:00:39-05:00" />
<meta name="publication-date" content="2014-04-23T13:19:00-04:00" />
<meta name="subsite" content="treeviewer" />
<meta name="path" content="treeviewer/biotreecontainer" />
<meta name="node-type" content="page" />
<meta name="jira-ticket" content="" />
<link type="text/css" rel="stylesheet" href="/core/assets/treeviewer/css/gbench-docs.css" />
<link type="text/css" rel="stylesheet" href="/core/assets/treeviewer/css/tvparams.css" /><meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="cms-edit-aux-url" content="http://cms.ncbi.nlm.nih.gov/node/3562/edit" />
<!-- Page headcontent end -->
<!-- PageFixtures resources begin -->
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer" />
<!-- PageFixtures resources end -->
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8CD95C7C8C009100000000008A006F.m_6" />
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4148854/css/4121862/3974050/3917732/251717/3990648/14534/45193/3534283/4128070/3894326/4005757/4062871.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4148854/css/3529741/3529739.css" media="print" /></head>
<body class=" col2 static">
<div class="grid">
<div class="col twelve_col nomargin shadow">
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
<div class="sysmessages">
<noscript>
<p class="nojs">
<strong>Warning:</strong>
The NCBI web site requires JavaScript to function.
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
</p>
</noscript>
</div>
<!--/.sysmessage-->
<div class="wrap">
<div class="page">
<div xmlns:xi="http://www.w3.org/2001/XInclude">
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer">
<section class="usa-banner">
<div class="usa-accordion">
<header class="usa-banner-header">
<div class="usa-grid usa-banner-inner">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
<p>An official website of the United States government</p>
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
<span class="usa-banner-button-text">Here's how you know</span>
</button>
</div>
</header>
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
<div class="usa-banner-guidance-gov usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
<div class="usa-media_block-body">
<p>
<strong>The .gov means it's official.</strong>
<br />
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you're on a federal
government site.
</p>
</div>
</div>
<div class="usa-banner-guidance-ssl usa-width-one-half">
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
<div class="usa-media_block-body">
<p>
<strong>The site is secure.</strong>
<br />
The <strong>https://</strong> ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
</p>
</div>
</div>
</div>
</div>
</section>
<div class="usa-overlay"></div>
<header class="ncbi-header" role="banner" data-section="Header">
<div class="usa-grid">
<div class="usa-width-one-whole">
<div class="ncbi-header__logo">
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
</a>
</div>
<div class="ncbi-header__account">
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
<span class="fa fa-user" aria-hidden="true">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
<g style="fill: #fff">
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
</g>
</svg>
</span>
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
<span class="sr-only">Show account info</span>
</button>
</div>
<div class="ncbi-popup-anchor">
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
<div class="ncbi-popup-head">
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
<span class="fa fa-times">
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
</svg>
</span>
<span class="usa-sr-only">Close</span></button>
<h4>Account</h4>
</div>
<div class="account-user-info">
Logged in as:<br />
<b><span class="username" id="uname_long">username</span></b>
</div>
<div class="account-links">
<ul class="usa-unstyled-list">
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
</ul>
</div>
</div>
</div>
</div>
</div>
</header>
<div role="navigation" aria-label="access keys">
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
</div>
<section data-section="Alerts">
<div class="ncbi-alerts-placeholder"></div>
</section>
</div>
</div>
<!--/.header-->
<div class="header">
<div class="res_logo"><h1 class="res_name"><a href="/tools/treeviewer/" title="NCBI Tree Viewer home">NCBI Tree Viewer</a></h1><h2 class="res_tagline"></h2></div>
<div class="search"><form method="get" action="/gquery/"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="gquery" selected="selected">All Databases</option><option value="refseq">RefSeq</option><option value="books">Books</option><option value="cdd" class="last">Conserved Domains</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search All Databases" value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="isEnabled:false,disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'no',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div></form></div>
</div>
<div class="nav_and_browser">
<div class="localnav"><ul class="jig-ncbilocalnav">
<li>
<a href="#">NCBI Tree Viewer</a>
<ul>
<li>
<a href="/tools/treeviewer/">Tree Viewer documentation home</a></li>
<li>
<a href="/projects/treeview/">Tree Viewer application home</a></li>
</ul>
</li>
<li>
<a href="#">For Users</a>
<ul>
<li>
<a href="/tools/treeviewer/releasenotes">Release notes</a></li>
<li>
<a href="/tools/treeviewer/faq">Frequently Asked Questions</a></li>
<li>
<a href="/tools/treeviewer/videos">Videos</a></li>
</ul>
</li>
<li>
<a href="#">User Tutorials</a>
<ul>
<li>
<a href="/tools/treeviewer/tutorial-uud">User uploaded data</a></li>
<li>
<a href="/tools/treeviewer/tutorial-editlabels">Edit Labels Dialog</a></li>
<li>
<a href="/tools/treeviewer/tutorial-search">Tree View Search</a></li>
</ul>
</li>
<li>
<a href="#">For Developers</a>
<ul>
<li>
<a href="/tools/treeviewer/embeddingapi">Embedding API manual</a></li>
<li>
<a href="/tools/treeviewer/macros">Tree Viewer Macros manual</a></li>
<li>
<a href="/tools/treeviewer/developerresources">Other Developer Resources</a></li>
</ul>
</li>
<li>
<a href="#">Related Resources</a>
<ul>
<li>
<a href="/projects/sviewer/">Sequence Viewer</a></li>
<li>
<a href="/projects/msaviewer/">Multiple Sequence Alignment Viewer</a></li>
</ul>
</li>
</ul></div>
</div>
<!-- was itemctrl -->
<div class="container">
<div id="maincontent" class="content col twelve_col last">
<div class="col1">
<h1>
BioTreeContainer and its Features</h1>
<h2>
Formal Definition</h2>
<p>
<a href="https://www.ncbi.nlm.nih.gov/IEB/ToolBox/CPP_DOC/asn_spec/BioTreeContainer.html">http://www.ncbi.nlm.nih.gov/IEB/ToolBox/CPP_DOC/asn_spec/BioTreeContainer.html</a></p>
<p>
The BioTreeContainer consist of a list of <strong>nodes</strong> linked by unique node ids. Each node can have one or more features. A feature is a property of the node such as a sequence identifier, organism name or a color. Each feature has a unique identifying name within the tree and those feature names are specified in the tree's feature dictionary, <strong>fdict</strong>. Feature values are always strings. Some of the feature types have special meanings that can affect the trees layout or appearance. All features can be returned to the Treeviewer client in the JSON node descriptions.</p>
<h2 id="featureswithspecialmeaning">
Feature values with Special Meaning</h2>
<table border="1" cellpadding="1" cellspacing="1">
<thead>
<tr>
<th scope="col">
<em>Feature Value</em></th>
<th scope="col">
<em>Meaning</em></th>
</tr>
</thead>
<tbody>
<tr>
<td>
<strong>$URL</strong></td>
<td>
If the value of a feature contains the keyword $URL then the specified link will be displayed in the tooltip for the node. The usage should follow the following example:<br />
<br />
$url=https://developer.mozilla.org/en-US/docs/Web/JavaScript/Reference/Global_Objects/String/substring$text=substring<br />
<br />
The feature value starts with <strong>$url</strong>=<br />
The text between <strong>$url</strong>= and <strong>$text</strong>= is the link itself<br />
Text after <strong>$text</strong>= is the display part of the link</td>
</tr>
</tbody>
</table>
<h2 id="featurenameswithspecialmeaning">
Feature names with Special Meaning</h2>
<table border="1" cellpadding="1" cellspacing="1">
<thead>
<tr>
<th scope="col">
Feature Name</th>
<th scope="col">
Meaning</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<strong>label</strong></td>
<td>
This feature holds the default label displayed for the node. Users can specify label formats based on other features if they dont want to use <strong>label</strong> as the default.</td>
</tr>
<tr>
<td>
<strong>seq-id</strong></td>
<td>
ID of the sequence associated with the node</td>
</tr>
<tr>
<td>
<strong>seq-title</strong></td>
<td>
Title of the sequence associated with the node</td>
</tr>
<tr>
<td>
<strong>accession-nbr</strong></td>
<td>
Sequence accession number</td>
</tr>
<tr>
<td>
<strong>tax-id</strong></td>
<td>
Taxonomic ID of the organism associated with the node</td>
</tr>
<tr>
<td>
<strong>dist</strong></td>
<td>
Distance from the node to its parent. This distance is used when formatting the tree for distance-based layouts.</td>
</tr>
<tr>
<td>
<strong>cluster-id</strong></td>
<td>
A cluster ID can be assigned to a group of nodes that have some common property.  All nodes with the same cluster ID are then drawn with a common color to show their association.</td>
</tr>
<tr>
<td>
<strong>marker</strong></td>
<td>
A marker attribute that changes the color and size at which a node is drawn.</td>
</tr>
<tr>
<td>
<strong>$NODE_COLLAPSED</strong></td>
<td>
When this feature set to 1, all nodes underneath this node are hidden (collapsed). When this feature is 0 or not present, child nodes appear normally.</td>
</tr>
<tr>
<td>
<strong>$NODE_SIZE</strong></td>
<td>
This feature is the size, expressed as a radius, at which the node is drawn. If this feature is not present for a node, the node is drawn with the default radius.</td>
</tr>
<tr>
<td>
<strong>$NODE_BOUNDED</strong></td>
<td>
This feature specifies a colored boundary to draw around the node and all its children.</td>
</tr>
<tr>
<td>
<strong>$NODE_COLOR</strong></td>
<td>
Color with which to draw the node. If $NODE_COLOR is not specified, the default color is used.</td>
</tr>
<tr>
<td>
<strong>$LABEL_COLOR</strong></td>
<td>
Color with which to draw the label text. If $LABEL_COLOR is not specified, the default color is used.</td>
</tr>
<tr>
<td>
<strong>$LABEL_BG_COLOR</strong></td>
<td>
Color with which to draw background of the label text. If $LABEL_BG_COLOR is not specified, no background is drawn.</td>
</tr>
<tr>
<td>
<strong>$EDGE_COLOR</strong></td>
<td>
Color of the edge from this node to its parent. If $EDGE_COLOR is not specified, the default color is used.</td>
</tr>
<tr>
<td>
<strong>$EDGE_GRADIENT</strong></td>
<td>
If this feature is set to “1” the color of the edge from this node to its parent will be interpolated between the $EDGE_COLOR of this node and the $EDGE_COLOR of the parent node.</td>
</tr>
<tr>
<td>
<strong>$SEL_CLUSTERS</strong></td>
<td>
This feature is similar to cluster-id except that it contains a list of clusters created via selection or macros. Each selection cluster has a unique name and color.</td>
</tr>
<tr>
<td>
<strong>$PRIORITY</strong></td>
<td>
The $PRIORITY feature is an integer value. When a node is collapsed and it does not already have a label assigned, we search all the nodes underneath it and if one or more have the $PRIORITY feature, than the label of the node with the highest $PRIORITY value is used as the label for the collapsed node.  If there is a tie for highest value, we pick the node closest to the center of the subtree.  Also, if any nodes have a priority &gt; 1000, the node is not collapsed (if the user is using the collapse-to-viewport feature).</td>
</tr>
</tbody>
</table>
</div>
<!--/.col1-->
<div class="col2">
<h2>
Table of Contents</h2><ul>
<li>
<a href="/tools/treeviewer/">Tree Viewer documentation home</a></li>
<li>
<a href="/projects/treeview/">Tree Viewer application home</a></li>
<li>
For Users
<ul>
<li>
<a href="/tools/treeviewer/releasenotes">Release notes</a></li>
<li>
<a href="/tools/treeviewer/faq">Frequently Asked Questions</a></li>
<li>
<a href="/tools/treeviewer/videos">Videos</a></li>
</ul>
</li>
<li>
User Tutorials
<ul>
<li>
<a href="/tools/treeviewer/tutorial-uud">User uploaded data</a></li>
<li>
<a href="/tools/treeviewer/tutorial-editlabels">Edit Labels Dialog</a></li>
<li>
<a href="/tools/treeviewer/tutorial-search">Tree View Search</a></li>
</ul>
</li>
<li>
For Developers
<ul>
<li>
<a href="/tools/treeviewer/embeddingapi">Embedding API manual</a></li>
<li>
<a href="/tools/treeviewer/macros">Tree Viewer Macros manual</a></li>
<li>
<a href="/tools/treeviewer/developerresources">Other Developer Resources</a></li>
</ul>
</li>
<li>
Related Resources
<ul>
<li>
<a href="/projects/sviewer/">Sequence Viewer</a></li>
<li>
<a href="/projects/msaviewer/">Multiple Sequence Alignment Viewer</a></li>
</ul>
</li>
</ul>
</div>
<!--/.col2-->
<div class="col3">
</div>
<!--/.col3-->
<div class="col4">
</div>
<!--/.col4-->
<div class="col5">
</div>
<div class="col6">
</div>
<div class="col7">
</div>
<div class="col8">
</div>
<div class="col9">
</div>
</div><!--/.content-->
</div><!--/.container-->
<div id="NCBIFooter_dynamic">
<div class="breadcrumbs">You are here:
<span id="breadcrumb_text"><a href="/guide/">NCBI</a></span></div>
<a id="help-desk-link" class="help_desk" href="https://support.ncbi.nlm.nih.gov/ics/support/default.asp?Time=2025-03-05T16:49:48-05:00&amp;Snapshot=%2Fprojects%2Fstaticsites%2Ftreeview%2Ftreeview@1.5&amp;Host=portal105&amp;ncbi_phid=CE8CD95C7C8C009100000000008A006F&amp;ncbi_session=CE8B5AF87C7FFCB1_0191SID&amp;from=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Ftools%2Ftreeviewer%2Fbiotreecontainer%2F&amp;Ncbi_App=treeviewer&amp;Page=static&amp;style=classic&amp;deptID=28049">Support Center</a>
<noscript><img alt="" src="/stat?jsdisabled=true&amp;ncbi_app=treeviewer&amp;ncbi_db=&amp;ncbi_pdid=static&amp;ncbi_phid=CE8CD95C7C8C009100000000008A006F" /></noscript>
</div>
<div xmlns:xi="http://www.w3.org/2001/XInclude">
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer">
<section class="icon-section">
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
<div class="grid-container container">
<div class="icon-section_container">
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
<title>Twitter</title>
<g id="twitterx1008">
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
</g>
</svg>
</a>
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>Facebook</title>
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<title>LinkedIn</title>
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
</path>
</svg></a>
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
<defs>
<style>
.cls-11,
.cls-12 {
fill: #737373;
}
.cls-11 {
fill-rule: evenodd;
}
</style>
</defs>
<title>GitHub</title>
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
</path>
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
</path>
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
</path>
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
</path>
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
</path>
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
</path>
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
</svg></a>
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
<defs><style>.cls-1{fill:#737373;}</style></defs>
<title>NCBI Insights Blog</title>
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
</svg>
</a>
</div>
</div>
</section>
<section class="container-fluid bg-primary">
<div class="container pt-5">
<div class="row mt-3">
<div class="col-lg-3 col-12">
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
<ul class="list-inline social_media">
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
<title>Twitter</title>
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
</g>
<defs>
<clipPath id="clip0_65276_3946">
<rect width="35" height="35" fill="white"></rect>
</clipPath>
</defs>
</svg>
</a></li>
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
<title>Facebook</title>
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
</g>
<defs>
<clipPath id="clip0_1717_1086">
<rect width="35" height="35" fill="white"></rect>
</clipPath>
</defs>
</svg>
</a></li>
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
<title>Youtube</title>
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
</g>
<defs>
<clipPath id="clip0_1717_1101">
<rect width="35" height="35" fill="white"></rect>
</clipPath>
</defs>
</svg>
</a></li>
</ul>
</div>
<div class="col-lg-3 col-12">
<p class="address_footer text-white">National Library of Medicine<br />
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
Bethesda, MD 20894</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
</div>
<div class="col-lg-3 col-12 centered-lg">
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
</div>
</div>
<div class="row">
<div class="col-lg-12 centered-lg">
<nav class="bottom-links">
<ul class="mt-3">
<li>
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
</li>
<li>
<a class="text-white" href="https://www.nih.gov/">NIH</a>
</li>
<li>
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
</li>
<li>
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
</li>
</ul>
</nav>
</div>
</div>
</div>
</section>
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
</div>
</div>
<!--/.footer-->
<p class="last-updated small">Last updated: 2017-03-10T16:00:39-05:00</p>
</div>
<!--/.page-->
</div>
<!--/.wrap-->
<span class="PAFAppResources"></span>
</div><!-- /.twelve_col -->
</div>
<!-- /.grid -->
<!-- usually for JS scripts at page bottom -->
<span class="pagefixtures"></span>
<!-- CE8B5AF87C7FFCB1_0191SID /projects/staticsites/treeview/treeview@1.5 portal105 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
<script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4148854/js/3879255/4121861/3989973/4087685.js" snapshot="tools"></script></body>
</html>