841 lines
58 KiB
HTML
841 lines
58 KiB
HTML
<?xml version="1.0" encoding="utf-8"?>
|
||
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
||
<html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en">
|
||
|
||
<head>
|
||
<!-- AppResources meta begin -->
|
||
<meta name="paf-app-resources" content="" />
|
||
<!-- AppResources meta end -->
|
||
|
||
<!-- TemplateResources meta begin -->
|
||
<meta name="paf_template" content="StdNCol" />
|
||
|
||
<!-- TemplateResources meta end -->
|
||
|
||
<!-- Page meta begin -->
|
||
|
||
<!-- Page meta end -->
|
||
|
||
<!-- Logger begin -->
|
||
<meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_app" content="snp" /><meta xmlns:ncbi-portal="http://ncbi.gov/portal/XSLT/namespace" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" name="ncbi_pdid" content="static" />
|
||
<!-- Logger end -->
|
||
|
||
<title>RefSNP Report Help </title>
|
||
|
||
<!-- PageFixtures headcontent begin -->
|
||
|
||
|
||
<!-- PageFixtures headcontent end -->
|
||
|
||
<!-- AppResources external_resources begin -->
|
||
<script type="text/javascript" src="/core/jig/1.15.3/js/jig.min.js"></script>
|
||
|
||
<!-- AppResources external_resources end -->
|
||
|
||
<!-- Page headcontent begin -->
|
||
<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
||
<meta name="node-id" content="6020" />
|
||
<meta name="revision-id" content="40865" />
|
||
<meta name="created" content="2017-06-13T09:59:17-04:00" />
|
||
<meta name="modified" content="2017-10-25T11:14:29-04:00" />
|
||
<meta name="publication-date" content="2017-06-13T09:58:00-04:00" />
|
||
<meta name="subsite" content="snp" />
|
||
<meta name="path" content="snp/docs/refsnp_report/helpdoc" />
|
||
<meta name="node-type" content="page" />
|
||
<meta name="jira-ticket" content="" />
|
||
<meta name="" content="" />
|
||
<!-- Page headcontent end -->
|
||
<!-- PageFixtures resources begin -->
|
||
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer" />
|
||
|
||
<!-- PageFixtures resources end -->
|
||
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8CC6247C8030D10000000000B40087.m_5" /><script type="text/javascript"><!--
|
||
var ScriptPath = '/portal/';
|
||
var objHierarchy = {"name":"PAFAppLayout","type":"Layout","realname":"PAFAppLayout",
|
||
"children":[{"name":"PAFAppLayout.AppController","type":"Cluster","realname":"PAFAppLayout.AppController",
|
||
"children":[{"name":"PAFAppLayout.AppController.AppResources","type":"Portlet","realname":"PAFAppLayout.AppController.AppResources","shortname":"AppResources"},
|
||
{"name":"PAFAppLayout.AppController.RequestProcessor","type":"Portlet","realname":"PAFAppLayout.AppController.RequestProcessor","shortname":"RequestProcessor"},
|
||
{"name":"PAFAppLayout.AppController.Controller","type":"Cluster","realname":"PAFAppLayout.AppController.Controller",
|
||
"children":[{"name":"PAFAppLayout.AppController.Controller.PAFStaticContentController","type":"Portlet","realname":"PAFAppLayout.AppController.Controller.PAFControllerSelector.PAFStaticContentController","shortname":"PAFStaticContentController"}]},
|
||
{"name":"PAFAppLayout.AppController.Page","type":"Cluster","realname":"PAFAppLayout.AppController.Page",
|
||
"children":[{"name":"PAFAppLayout.AppController.Page.PAFPageSelectorData","type":"Portlet","realname":"PAFAppLayout.AppController.Page.PAFPageSelector.PAFPageSelectorData","shortname":"PAFPageSelectorData"},
|
||
{"name":"PAFAppLayout.AppController.Page.CustomStaticPage","type":"Cluster","realname":"PAFAppLayout.AppController.Page.CustomStaticPage",
|
||
"children":[{"name":"PAFAppLayout.AppController.Page.CustomStaticPage.MainPortlet","type":"Portlet","realname":"PAFAppLayout.AppController.Page.CustomStaticPage.MainPortlet","shortname":"MainPortlet"}]}]},
|
||
{"name":"PAFAppLayout.AppController.PageFixtures","type":"Cluster","realname":"PAFAppLayout.AppController.PageFixtures",
|
||
"children":[{"name":"PAFAppLayout.AppController.PageFixtures.PageFixturesP","type":"Portlet","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.PageFixturesP","shortname":"PageFixturesP"},
|
||
{"name":"PAFAppLayout.AppController.PageFixtures.SearchBar","type":"Cluster","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.SearchBar",
|
||
"children":[{"name":"PAFAppLayout.AppController.PageFixtures.SearchBar.SearchBarChooser","type":"Portlet","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.SearchBar.SearchBarChooser","shortname":"SearchBarChooser"},
|
||
{"name":"PAFAppLayout.AppController.PageFixtures.SearchBar.PAFSearchBar","type":"Portlet","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.SearchBar.PAFSearchBar","shortname":"PAFSearchBar"}]},
|
||
{"name":"PAFAppLayout.AppController.PageFixtures.HeaderFooter","type":"Cluster","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.HeaderFooter",
|
||
"children":[{"name":"PAFAppLayout.AppController.PageFixtures.HeaderFooter.NCBIBreadcrumbs","type":"Portlet","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.HeaderFooter.NCBIBreadcrumbs","shortname":"NCBIBreadcrumbs"},
|
||
{"name":"PAFAppLayout.AppController.PageFixtures.HeaderFooter.NCBIHelpDesk","type":"Portlet","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.HeaderFooter.NCBIHelpDesk","shortname":"NCBIHelpDesk"},
|
||
{"name":"PAFAppLayout.AppController.PageFixtures.HeaderFooter.NCBIApplog_NoScript_Ping","type":"Portlet","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.HeaderFooter.NCBIApplog_NoScript_Ping","shortname":"NCBIApplog_NoScript_Ping"}]},
|
||
{"name":"PAFAppLayout.AppController.PageFixtures.LocalNavPortlet","type":"Portlet","realname":"PAFAppLayout.AppController.PageFixtures.PAFPageFixtures.LocalNavPortlet","shortname":"LocalNavPortlet"}]},
|
||
{"name":"PAFAppLayout.AppController.TemplateResources","type":"Cluster","realname":"PAFAppLayout.AppController.TemplateResources",
|
||
"children":[{"name":"PAFAppLayout.AppController.TemplateResources.StdNColResources","type":"Portlet","realname":"PAFAppLayout.AppController.TemplateResources.PAFTemplateResources.StdNColResources","shortname":"StdNColResources"}]},
|
||
{"name":"PAFAppLayout.AppController.Logger","type":"Portlet","realname":"PAFAppLayout.AppController.Logger","shortname":"Logger"},
|
||
{"name":"PAFAppLayout.AppController.DebugConsole","type":"Portlet","realname":"PAFAppLayout.AppController.DebugConsole","shortname":"DebugConsole"}]}]};
|
||
--></script>
|
||
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4206108/css/4121862/3974050/3917732/251717/4154243/14534/45193/3534283/4128070/4062871/4005757.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4206108/css/3529741/3529739.css" media="print" /><script type="text/javascript">
|
||
|
||
var ObjectLinks=[{i:0, ename: "p$ExL", esid:"*", sname: "p$ExL", ssid:"*", dname:"p$el", dsid:"0",m:"CopyValue",p:[],f: function(src, dst) {fn_CopyValue(src, dst);}}]
|
||
|
||
|
||
var ActiveNames = {"p$ExL":1};
|
||
</script></head>
|
||
<body class=" static">
|
||
<div class="grid">
|
||
<div class="col twelve_col nomargin shadow">
|
||
<!-- System messages like service outage or JS required; this is handled by the TemplateResources portlet -->
|
||
<div class="sysmessages">
|
||
<noscript>
|
||
<p class="nojs">
|
||
<strong>Warning:</strong>
|
||
The NCBI web site requires JavaScript to function.
|
||
<a href="/guide/browsers/#enablejs" title="Learn how to enable JavaScript" target="_blank">more...</a>
|
||
</p>
|
||
</noscript>
|
||
</div>
|
||
<!--/.sysmessage-->
|
||
<div class="wrap">
|
||
<div class="page">
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer">
|
||
<section class="usa-banner">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner-header">
|
||
<div class="usa-grid usa-banner-inner">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
|
||
<p>An official website of the United States government</p>
|
||
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
|
||
<span class="usa-banner-button-text">Here's how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
|
||
<div class="usa-banner-guidance-gov usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The .gov means it's official.</strong>
|
||
<br />
|
||
Federal government websites often end in .gov or .mil. Before
|
||
sharing sensitive information, make sure you're on a federal
|
||
government site.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner-guidance-ssl usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The site is secure.</strong>
|
||
<br />
|
||
The <strong>https://</strong> ensures that you are connecting to the
|
||
official website and that any information you provide is encrypted
|
||
and transmitted securely.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<div class="usa-overlay"></div>
|
||
<header class="ncbi-header" role="banner" data-section="Header">
|
||
|
||
<div class="usa-grid">
|
||
<div class="usa-width-one-whole">
|
||
|
||
<div class="ncbi-header__logo">
|
||
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
|
||
</a>
|
||
</div>
|
||
|
||
<div class="ncbi-header__account">
|
||
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
|
||
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
|
||
<span class="fa fa-user" aria-hidden="true">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
|
||
<g style="fill: #fff">
|
||
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
|
||
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
|
||
</g>
|
||
</svg>
|
||
</span>
|
||
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
|
||
<span class="sr-only">Show account info</span>
|
||
</button>
|
||
</div>
|
||
|
||
<div class="ncbi-popup-anchor">
|
||
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
|
||
<div class="ncbi-popup-head">
|
||
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
|
||
<span class="fa fa-times">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
|
||
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
|
||
</svg>
|
||
</span>
|
||
<span class="usa-sr-only">Close</span></button>
|
||
<h4>Account</h4>
|
||
</div>
|
||
<div class="account-user-info">
|
||
Logged in as:<br />
|
||
<b><span class="username" id="uname_long">username</span></b>
|
||
</div>
|
||
<div class="account-links">
|
||
<ul class="usa-unstyled-list">
|
||
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
|
||
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
|
||
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
|
||
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<div role="navigation" aria-label="access keys">
|
||
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
|
||
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
|
||
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
|
||
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
|
||
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
|
||
</div>
|
||
<section data-section="Alerts">
|
||
<div class="ncbi-alerts-placeholder"></div>
|
||
</section>
|
||
</div>
|
||
</div>
|
||
<!--/.header-->
|
||
<div class="header">
|
||
<div class="res_logo"><h1 class="res_name"><a href="/snp/" title="dbSNP home">dbSNP</a></h1><h2 class="res_tagline">Small genetic variation</h2></div>
|
||
<div class="search"><form method="get" action="/snp/"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="snp" selected="selected">SNP</option><option value="refseq">RefSeq</option><option value="books">Books</option><option value="protein" class="last">Protein</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen">MedGen</option><option value="mesh">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search SNP" value="" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="isEnabled:false,disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'no',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><input type="hidden" name="p$a" id="p$a" /><input type="hidden" name="p$l" id="p$l" value="PAFAppLayout" /><input type="hidden" name="p$st" id="p$st" value="snp" /><input name="SessionId" id="SessionId" value="CE8B5AF87C7FFCB1_0191SID" disabled="disabled" type="hidden" /><input name="Snapshot" id="Snapshot" value="/projects/staticsites/snp/snpdoc@1.10" disabled="disabled" type="hidden" /></form><ul class=" inline_list searchlinks"><li>
|
||
<a href="/snp/advanced">Advanced</a>
|
||
</li></ul></div>
|
||
|
||
</div>
|
||
<div class="nav_and_browser">
|
||
|
||
</div>
|
||
|
||
<!-- was itemctrl -->
|
||
<div class="container">
|
||
<div id="maincontent" class="content col twelve_col last">
|
||
<div class="col1">
|
||
|
||
|
||
<div id="whatisnew">
|
||
<h2>History</h2>
|
||
</div>
|
||
|
||
|
||
<p>
|
||
Until dbSNP build 151 (March 2018), a legacy RefSNP page (as shown below) was used to report the details of a RefSNP. Then after a whole new design of dbSNP database (since dbSNP build 152), a redesigned NCBI dbSNP refSNP Web Report page has replaced the old page to provide a more user-friendly interface. From the two images shown below, we can see the differences between the two versions of web report.
|
||
</p>
|
||
|
||
|
||
<br>
|
||
|
||
|
||
<table border="0" cellpadding="1" cellspacing="1">
|
||
<tbody>
|
||
<tr width="90%">
|
||
<td style="text-align:center; width:45%">
|
||
<h3>Classic (legacy) Site</h3>
|
||
</td>
|
||
<td style="text-align:center; width:45%">
|
||
<h3>Current Site</h3>
|
||
</td>
|
||
</tr>
|
||
<tr width="90%">
|
||
<td style="text-align:center; width:45%">
|
||
<img src="/core/assets/snp/images/Legacy_RefSNP.png" width="95%" alt="Legacy Site" class="scaleImg" />
|
||
</td>
|
||
<td style="text-align:center; width:45%">
|
||
<img src="/core/assets/snp/images/Current_RefSNP_horizontal_tabs.png" width="95%" alt="Current Site" class="scaleImg" />
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
|
||
<br><br>
|
||
<p>
|
||
The rest of this tutorial will focus on the redesigned NCBI dbSNP RefSNP Web Report. The aim is to provide an overview of the page structure and help users to find the information they need. More details about RefSNP can be found <a href="/snp/docs/RefSNP_about">here</a>. Send us email with feedback about any problems you may encounter to <strong>dbSNP-support@nlm.nih.gov</strong>.</p>
|
||
<br>
|
||
|
||
<h2>RefSNP Report</h2>
|
||
|
||
<p>
|
||
dbSNP RefSNP Web Report is an interactive page for browsing the submitted and computed information for a single Reference SNP variant (RefSNP, rs).</p>
|
||
<p>
|
||
There are a few major parts on the top of RefSNP web Report page, as labelled in the image below. <br>
|
||
<ul>
|
||
<li>(A) Search Box: The Search box is used to find and explore other RefSNP (rs) records. Currently the page only supports searching for exact rs identifiers, not for rs attributes. Enter the rs identifier (ie. 'rs268') and click 'Search'. </li>
|
||
<li>(B) Summary: Summary section provides an overview of the variant, reports the allele in the forward orientation of the chromosome, and summary allele frequencies when available. Links to related records in other databases are listed in the right hand column</li>
|
||
<li>(C) Download Link: The information in display is available in JSON format through the Download link at the upper right. That function is provided by the Variation Service API, and more information is available <a href="api.ncbi.nlm.nih.gov/variation/v0/#">here</a></li>
|
||
<li>(D) Tabs: The RefSNP report separates details of the variation into various categories and lists them in the horizontal tabs. The default tab is "Frequency".</li>
|
||
<li>(E) Tab Content: The tab content is displayed beneath the tabs.</li>
|
||
</ul>
|
||
<br>
|
||
<img src="/core/assets/snp/images/RefSNP_Overview_horizontal_tabs_alfa.png" alt="RefSNP_Overview_horizontal_tabs_alfa" width="80%" class="scaleImg" />
|
||
<br />
|
||
<p>
|
||
There are eight tabs in total and they are listed below. Each tab content will be introduced in more details later in this tutorial.
|
||
</p>
|
||
<ul>
|
||
<li>Frequency</li>
|
||
<li>Variant Details</li>
|
||
<li>Clinical Significance</li>
|
||
<li>HGVS</li>
|
||
<li>Submissions</li>
|
||
<li>History</li>
|
||
<li>Publications</li>
|
||
<li>Flanks</li>
|
||
</ul>
|
||
|
||
<h3>Summary</h3>
|
||
<p>
|
||
Summary contains the essential information about the variant in the form of tag-value pairs for Organism, Position, Alleles, Variation Type, Frequency, Clinical Significance, Gene and Consequence, Publications, and Genomic View. SNPs with LitVar information are also labeled on refsnp page, under the 'Publications' item.</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_rs268_horizontal_tabs.png" alt="RefSNPReport_rs268_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<table border="1" cellpadding="1" cellspacing="1">
|
||
<tbody>
|
||
<tr height="40">
|
||
<td height="40">
|
||
<strong>Tag</strong>
|
||
</td>
|
||
<td>
|
||
<strong>Description</strong>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td>Organism</td>
|
||
<td>Human, <em>Homo sapiens</em></td>
|
||
</tr>
|
||
<tr>
|
||
<td>Position</td>
|
||
<td>
|
||
Variant map position on the latest assembly, i.e. GRCh38.p7. The assembly version will also include the GRC patch version 'p7'. The different patch versions, p6, p7, etc. does not disrupt the position on the primary assembly version GRCh38. See the online documentation for further explanation of patches (<a href="https://www.ncbi.nlm.nih.gov/grc/help/patches/">https://www.ncbi.nlm.nih.gov/grc/help/patches/</a>).
|
||
Detailed list of all positions is available in the Variant Details and Aliases tabs.
|
||
<pre>
|
||
NOTE:
|
||
A dbSNP RefSNP is a cluster of variants that have the same position and type when mapped to the preferred top-level
|
||
sequence. The position is the deletion interval of the variant. It includes adjacent nucleotides in repeating regions
|
||
when the variant is shiftable, that is, it includes all nucleotides that could be affected by the variant. This is what
|
||
is displayed in the "Position" field in the 'Detail' section for a RefSNP. However, the web page displays alleles in
|
||
HGVS notation. HGVS right-shifts shiftable variants, so HGVS positions can differ from the displayed common "Position".
|
||
For example, consider inserting an A into a string of 5 A's that starts at position 11 in a sequence named SEQ1. The
|
||
canonical SPDI would be SEQ:11:AAAAA:AAAAAA (1-based for illustration). So the RefSNP position would be 11-15. The
|
||
corresponding HGVS expression using a right-shifted 1-based position of 15 would be SEQ1:g.15dup.</pre>
|
||
</td>
|
||
</tr>
|
||
<tr>
|
||
<td>Alleles</td>
|
||
<td>Reference and variant alleles for the rs. Detailed list of all alleles is available in the Variant Details and Aliases tabs.</td>
|
||
</tr>
|
||
<tr>
|
||
<td>Variation type</td>
|
||
<td>One of the possible variation types: SNV : Single Nucleotide Variation; MNV : Multiple Nucleotide Variation; Insertion; Deletion; Indel : Insertion and Deletion; Identity; None. </td>
|
||
</tr>
|
||
<tr>
|
||
<td>Frequency</td>
|
||
<td>
|
||
Minor Allele Frequency (<a href="https://www.ncbi.nlm.nih.gov/variation/docs/glossary/#maf">MAF</a>) listed as a percentage representing a fraction, where the numerator is the number of samples observed and the denominator is the total number of samples, as reported in a given study. <br />
|
||
Minor allele 'G' with a frequency of 0.0052 means that 'G' is observed 26 times among 5008 samples, as reported by the 1000 Genomes study. List of all reported frequencies for refrence and alternate alleles from various studies and populations is in the Frequency tab.</td>
|
||
</tr>
|
||
<tr>
|
||
<td>Clinical Significance</td>
|
||
<td>
|
||
Link to ClinVar, if any clinical significance data exist there, or an indication that there are no clinical significance data available in ClinVar for that rs. <br />
|
||
If data are present in ClinVar, more links are available in the Clinical Significance tab. </td>
|
||
</tr>
|
||
<tr>
|
||
<td>Gene : Consequence</td>
|
||
<td>
|
||
Gene symbol (ie. LPL) and <a href="https://www.ncbi.nlm.nih.gov/variation/docs/glossary/#MolCon">molecular consequence</a> based on RefSeq mRNA or protein annotations. <br />
|
||
Detailed list is available in the Variant Details tab.</td>
|
||
</tr>
|
||
<tr>
|
||
<td>Publications</td>
|
||
<td>
|
||
Number of citations where this rs was mentioned. <br />
|
||
Detailed list is available in the Publications tab.</td>
|
||
</tr>
|
||
<tr>
|
||
<td>Genomic View</td>
|
||
<td>
|
||
Link to a graphical view of the RefSNP in the latest genomic context along with RefSeq mRNA and protein. <br />
|
||
Use the zoom option within the Genomic View panel to inspect the nucleotides adjacent to the variant, and to see its neighbors.</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
<p>
|
||
<strong><a name="Frequency" id="Frequency">Frequency</a></strong>
|
||
</p>
|
||
<p id="frequency_tp">
|
||
The frequency tab displays a table showing the reference and alternate allele frequencies reported across various studies and populations. The top table provides frequency data from the NCBI <a href="/snp/docs/gsr/alfa/">ALFA</a> project, while the table below summarizes frequency data from all other projects in dbSNP, including 1000Genomes, GnomAD, and TOPMED.<br /><br />
|
||
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_frequency_horizontal_tabs_alfa.png" alt="RefSNPReport_frequency_horizontal_tabs_alfa" width="80%" class="scaleImg" />
|
||
<br /></p>
|
||
<p>In the ALFA frequency table:<br />
|
||
<ul><li>Population entries marked as "Global" refer to the entire study population, while those marked as "Sub" refer to specific population subgroupings (e.g., African, European, etc.).</li>
|
||
<li>Ref Allele and Alt Allele indicate the reference and alternate allele frequencies for each population group.</li>
|
||
<li>Sample Size gives the total number of chromosomes included in the analysis for each group.</li>
|
||
<li>Ref HMOZ and Alt HMOZ show the homozygous counts for the reference and alternate alleles, respectively.</li>
|
||
<li>HTRZ reflects the heterozygous counts within each population.</li>
|
||
<li>HWE P-value (HWEP) is the Hardy-Weinberg Equilibrium p-value, providing insight into whether the allele frequencies deviate from what is expected under equilibrium assumptions.</li>
|
||
</ul>
|
||
|
||
For more information on how these calculations are performed, please visit our detailed documentation <a href="/snp/docs/HWEP/">here</a>.<br /></p>
|
||
<p>
|
||
<strong><a name="Variant Details" id="Variant Details">Variant Details</a></strong>
|
||
</p>
|
||
<p id="variant_details_tp">
|
||
Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_).<br />
|
||
The corresponding transcript and protein locations are listed in adjacent lines, along with <a rel="nofollow" href="/variation/docs/glossary/#MolCon" class="external-link">molecular consequences</a> from <a rel="nofollow" href="http://www.sequenceontology.org/" class="external-link">Sequence Ontology</a>. When no protein placement is available, only the transcript is listed.<br />
|
||
Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view flanking nucleotides and neighbor rs use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_variantdetails_horizontal_tabs.png" alt="RefSNPReport_variantdetails_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="Clinical Significance" id="Clinical Significance">Clinical Significance</a></strong>
|
||
</p>
|
||
<p id="clinical_significance_tp">
|
||
Clinical Significance shows a list of <a rel="nofollow" href="/clinvar/docs/clinsig" class="external-link">clinical significance </a>entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. ;<a rel="nofollow" href="/clinvar/RCV000001615.2">RCV000001615.2</a>) or Allele ID (i.e. <a rel="nofollow" href="https://dev.ncbi.nlm.nih.gov/clinvar/variation/16589/">16589</a>) to access the full ClinVar report.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_clinsig_horizontal_tabs.png" alt="RefSNPReport_clinsig_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="HGVS" id="HGVS">HGVS</a></strong>
|
||
</p>
|
||
<p id="hgvs_tp">
|
||
HGVS tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. <a href="http://varnomen.hgvs.org/">HGVS name</a> is an expression for reporting sequence accession and version, sequence type, position, and allele change.<br />
|
||
The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_hgvs_horizontal_tabs.png" alt="RefSNPReport_hgvs_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="HGVS Filter" id="HGVS Filter">HGVS Filter</a></strong>
|
||
</p>
|
||
<p>
|
||
To limit the display to a sequence type or alias of interest use the “Filter” box as shown in the example below to select only desired HGVS aliases, based on NM sequences for mRNA.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_hgvs_filter_horizontal_tabs.png" alt="RefSNPReport_hgvs_filter_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="Submissions" id="Submissions">Submissions</a></strong>
|
||
</p>
|
||
<p id="submissions_tp">
|
||
Submissions tab displays variations originally submitted to dbSNP, and now supporting this RefSNP cluster (rs). <br />
|
||
We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. <br />
|
||
Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_submissions_horizontal_tabs.png" alt="RefSNPReport_submissions_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="Submissions Filter" id="Submissions Filter">Submissions Filter</a></strong>
|
||
</p>
|
||
<p>
|
||
The list of submitters can be long, so use the "Filter" box to find a given submitter (1000 Genomes).
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_submissions_filter_horizontal_tabs.png" alt="RefSNPReport_submissions_filter_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="History" id="History">History</a></strong>
|
||
</p>
|
||
<p id="history_tp">
|
||
History table is a listing of RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_history_horizontal_tabs.png" alt="RefSNPReport_history_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
History listing can be long, so use the "Filter" box to limit the display to only selected identifiers based on Associated ID or History Date, or Build number.
|
||
</p>
|
||
<p>
|
||
<strong><a name="Publications" id="Publications">Publications</a></strong>
|
||
</p>
|
||
<p id="publications_tp">
|
||
PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_publications_horizontal_tabs.png" alt="RefSNPReport_publications_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="Publications Filter" id="Publications Filter">Publications Filter</a></strong>
|
||
</p>
|
||
<p>
|
||
Publication list can be long, so use the "Filter" box to limit the display to selected citations based on PMID, Title, Author, Year or Journal.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_publications_filter_horizontal_tabs.png" alt="RefSNPReport_publications_filter_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="Flanks" id="Flanks">Flanks</a></strong>
|
||
</p>
|
||
<p>
|
||
The flanks tab allows you to display flanking bases from the reference assembly. You can choose to display 25, 50, 100, or 200 bases upstream and downstream of the variant. Flanking bases are displayed in forward orientation.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPReport_flanks_horizontal_tabs.png" alt="RefSNPReport_flanks_horizontal_tabs" width="80%" class="scaleImg" />
|
||
</p>
|
||
<p>
|
||
<strong><a name="Genomic regions, transcripts, and products" id="Genomic regions, transcripts, and products">Genomic regions, transcripts, and products</a></strong>
|
||
</p>
|
||
<p id="sequence_viewer_tp">
|
||
The "Genomic regions, transcripts, and products" section is the NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).<br />
|
||
Visit the <a href="/tools/sviewer/" class="external-link">Sequence Viewer</a> page for help with navigating inside the display and modifying the selection of displayed data tracks.<br />
|
||
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
|
||
</p>
|
||
<p>
|
||
<img src="/core/assets/snp/images/RefSNPreport_GenomicView.png" alt="RefSNPreport_GenomicView" class="scaleImg" />
|
||
</p>
|
||
<br />
|
||
<p>
|
||
<strong><a name="Comparisons between new and old designs" id="Comparisons between new and old designs">Comparisons between new and old designs</a></strong>
|
||
</p>
|
||
<p id="site_comparison">
|
||
To help users who are used to the classic RefSNP web page to make better use of the new design, comparisons between the new and old pages are summarized in a table below. In the table, screenshots of the above introduced sections are provided for both designs, and users can click on the thumbnails to see larger images.<br />
|
||
Note that there is no 'History' section on the classic page, and for several other sections (clinical significance, aliases, and publication) in the new design, their counterparts are combined and included in the 'summary' section in the old design.
|
||
</p>
|
||
<table border="1" cellpadding="1" cellspacing="1">
|
||
<tbody>
|
||
<tr height="40">
|
||
<td height="40">
|
||
<h3>Section</h3>
|
||
</td>
|
||
<td>
|
||
<h3>New Site</h3>
|
||
</td>
|
||
<td>
|
||
<h3>Classic Site</h3>
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
Summary
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_rs268_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_rs268_horizontal_tabs_thumb.png" alt="RefSNPReport_rs268_horizontal_tabs" class="scaleImg" /> </a>
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/old_RefSNPreport_Summary.png"><img src="/core/assets/snp/images/old_RefSNPreport_Summary_thumb.png" alt="RefSNPreport_Summary" class="scaleImg" /></a>
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
Frequency
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_frequency_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_frequency_horizontal_tabs_thumb.png" alt="RefSNPReport_frequency_horizontal_tabs" class="scaleImg" /></a>
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/old_RefSNPreport_Frequency.png"><img src="/core/assets/snp/images/old_RefSNPreport_Frequency_thumb.png" alt="RefSNPreport_Frequency" class="scaleImg" /></a>
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
Variant Details
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_variantdetails_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_variantdetails_horizontal_tabs_thumb.png" alt="RefSNPReport_variantdetails_horizontal_tabs" class="scaleImg" /></a>
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/old_RefSNPreport_VariantDetails.png"><img src="/core/assets/snp/images/old_RefSNPreport_VariantDetails_thumb.png" alt="RefSNPreport_VariantDetails" class="scaleImg" /></a>
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
Clinical Significance
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_clinsig_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_clinsig_horizontal_tabs_thumb.png" alt="RefSNPReport_clinsig_horizontal_tabs" class="scaleImg" /></a>
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/old_RefSNPreport_ClinicalSignificance.png"><img src="/core/assets/snp/images/old_RefSNPreport_ClinicalSignificance_thumb.png" alt="RefSNPreport_ClinicalSignificance" class="scaleImg" /></a>
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
HGVS
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_hgvs_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_hgvs_horizontal_tabs_thumb.png" alt="RefSNPReport_hgvs_horizontal_tabs" class="scaleImg" /></a>
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/old_RefSNPreport_Aliases.png"><img src="/core/assets/snp/images/old_RefSNPreport_Aliases_thumb.png" alt="RefSNPreport_Aliases" class="scaleImg" /></a>
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
Submission
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_submissions_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_submissions_horizontal_tabs_thumb.png" alt="RefSNPReport_submissions_horizontal_tabs" class="scaleImg" /></a>
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/old_RefSNPreport_Submissions.png"><img src="/core/assets/snp/images/old_RefSNPreport_Submissions_thumb.png" alt="RefSNPreport_Submissions" class="scaleImg" /></a>
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
History
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_history_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_history_horizontal_tabs_thumb.png" alt="RefSNPReport_history_horizontal_tabs" class="scaleImg" /></a>
|
||
</td>
|
||
<td height="40">
|
||
No History section
|
||
</td>
|
||
</tr>
|
||
<tr height="40">
|
||
<td height="40">
|
||
Publication
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/RefSNPReport_publications_horizontal_tabs.png"><img src="/core/assets/snp/images/RefSNPReport_publications_horizontal_tabs_thumb.png" alt="RefSNPReport_publications_horizontal_tabs" class="scaleImg" /></a>
|
||
</td>
|
||
<td height="40">
|
||
<a href="/core/assets/snp/images/old_RefSNPreport_Publications.png"><img src="/core/assets/snp/images/old_RefSNPreport_Publications_thumb.png" alt="RefSNPreport_Publications" class="scaleImg" /></a>
|
||
</td>
|
||
</tr>
|
||
</tbody>
|
||
</table>
|
||
</br>
|
||
</br>
|
||
</p>
|
||
</br></br></br></br>
|
||
</div>
|
||
<!--/.col1-->
|
||
<div class="col2">
|
||
|
||
</div>
|
||
<!--/.col2-->
|
||
<div class="col3">
|
||
|
||
</div>
|
||
<!--/.col3-->
|
||
<div class="col4">
|
||
|
||
</div>
|
||
<!--/.col4-->
|
||
<div class="col5">
|
||
|
||
</div>
|
||
<div class="col6">
|
||
|
||
</div>
|
||
<div class="col7">
|
||
|
||
</div>
|
||
<div class="col8">
|
||
|
||
</div>
|
||
<div class="col9">
|
||
|
||
</div>
|
||
</div><!--/.content-->
|
||
</div><!--/.container-->
|
||
<div id="NCBIFooter_dynamic">
|
||
<div class="breadcrumbs">You are here:
|
||
<span id="breadcrumb_text"><a href="/guide/">NCBI</a></span></div>
|
||
<a id="help-desk-link" class="help_desk" href="https://support.ncbi.nlm.nih.gov/ics/support/default.asp?Time=2025-03-05T03:44:00-05:00&Snapshot=%2Fprojects%2Fstaticsites%2Fsnp%2Fsnpdoc@1.10&Host=portal105&ncbi_phid=CE8CC6247C8030D10000000000B40087&ncbi_session=CE8B5AF87C7FFCB1_0191SID&from=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsnp%2Fdocs%2Frefsnp_report%2Fhelpdoc%2F&Ncbi_App=snp&Page=static&style=classic&deptID=28049" target="_blank">Support Center</a>
|
||
<noscript><img alt="" src="/stat?jsdisabled=true&ncbi_app=snp&ncbi_db=&ncbi_pdid=static&ncbi_phid=CE8CC6247C8030D10000000000B40087" /></noscript>
|
||
</div>
|
||
|
||
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer">
|
||
<section class="icon-section">
|
||
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
|
||
<div class="grid-container container">
|
||
<div class="icon-section_container">
|
||
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1008">
|
||
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
|
||
</g>
|
||
</svg>
|
||
</a>
|
||
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>Facebook</title>
|
||
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>LinkedIn</title>
|
||
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<defs>
|
||
<style>
|
||
.cls-11,
|
||
.cls-12 {
|
||
fill: #737373;
|
||
}
|
||
|
||
.cls-11 {
|
||
fill-rule: evenodd;
|
||
}
|
||
</style>
|
||
</defs>
|
||
<title>GitHub</title>
|
||
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
|
||
</path>
|
||
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
|
||
</path>
|
||
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
|
||
</path>
|
||
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
|
||
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
|
||
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
|
||
<defs><style>.cls-1{fill:#737373;}</style></defs>
|
||
<title>NCBI Insights Blog</title>
|
||
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
|
||
</svg>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
<section class="container-fluid bg-primary">
|
||
<div class="container pt-5">
|
||
<div class="row mt-3">
|
||
<div class="col-lg-3 col-12">
|
||
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
|
||
<ul class="list-inline social_media">
|
||
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
|
||
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_65276_3946">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Facebook</title>
|
||
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
|
||
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
|
||
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1086">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Youtube</title>
|
||
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
|
||
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
|
||
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1101">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
</ul>
|
||
</div>
|
||
<div class="col-lg-3 col-12">
|
||
<p class="address_footer text-white">National Library of Medicine<br />
|
||
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
|
||
Bethesda, MD 20894</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
|
||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
|
||
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
|
||
</div>
|
||
</div>
|
||
<div class="row">
|
||
<div class="col-lg-12 centered-lg">
|
||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
|
||
</div>
|
||
</div>
|
||
<!--/.footer-->
|
||
<p class="last-updated small">Last updated: 2017-10-25T11:14:29-04:00</p>
|
||
</div>
|
||
<!--/.page-->
|
||
</div>
|
||
<!--/.wrap-->
|
||
<span class="PAFAppResources"></span>
|
||
|
||
|
||
</div><!-- /.twelve_col -->
|
||
</div>
|
||
<!-- /.grid -->
|
||
|
||
|
||
|
||
<!-- usually for JS scripts at page bottom -->
|
||
<span class="pagefixtures"></span>
|
||
|
||
|
||
<!-- CE8B5AF87C7FFCB1_0191SID /projects/staticsites/snp/snpdoc@1.10 portal105 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
||
<span id="portal-csrf-token" style="display:none" data-token="CE8B5AF87C7FFCB1_0191SID"></span>
|
||
|
||
|
||
<script type='text/javascript' src='/portal/js/portal.js'></script><script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4206108/js/3879255/4121861/4206110/4087685.js" snapshot="snp"></script></body>
|
||
</html>
|
||
|