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<div id="details"><table id="gds_details" class="gds_panel" summary="GEO DataSet Details"><tr class="caption"><th colspan="5">
DataSet Record GDS3717:
<a href="/geoprofiles?term=GDS3717[ACCN]" target="_blank" class="button" title="View Expression Profiles">
Expression Profiles
</a><a href="#details" class="button" onclick="displayAnalysis(3717); return true" title="Data Analysis Tools">
Data Analysis Tools
</a><a href="#details" class="button" onclick="displaySamples(3717); return true" title="Sample Subsets">
Sample Subsets
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Title:
</th><td colspan="3">NOTCH antagonist SAHM1 effect on T-ALL cell lines</td><td id="detailsRightCol" rowspan="7"><fieldset><legend>Cluster Analysis</legend><a id="clusterLink" title="GDS3717 Cluster Analysis" href="/geo/gds/analyze/analyze.cgi?ID=GDS3717" target="_blank"><img alt="GDS3717 Cluster Image" width="80" height="80" src="/geo/img/UPGMA/UCorrelated/GDS3717i.png" /></a></fieldset><fieldset><legend>Download</legend><ul><li><a href="https://ftp.ncbi.nlm.nih.gov/geo/datasets/GDS3nnn/GDS3717/soft/GDS3717_full.soft.gz" title="Contains DataSet information, experiment variable subsets and expression value measurements (plain text, tab-delimited format)." class="dataset-soft-full">
DataSet full SOFT file
</a></li><li><a href="https://ftp.ncbi.nlm.nih.gov/geo/datasets/GDS3nnn/GDS3717/soft/GDS3717.soft.gz" title="Contains DataSet information, experiment variable subsets, expression value measurements and up-to-date gene annotation for the DataSet Platform (plain text, tab-delimited format)." class="dataset-soft">
DataSet SOFT file
</a></li><li><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE18nnn/GSE18198/soft/GSE18198_family.soft.gz" title="Contains the complete, original, submitter-supplied records that form the basis of this DataSet (plain text, tab-delimited format)." class="series-family-soft">
Series family SOFT file
</a></li><li><a href="https://ftp.ncbi.nlm.nih.gov/geo/series/GSE18nnn/GSE18198/miniml/GSE18198_family.xml.tgz" title="Contains the complete, original, submitter-supplied records that form the basis of this DataSet (XML format)." class="series-family-miniml">
Series family MINiML file
</a></li><li><a href="https://ftp.ncbi.nlm.nih.gov/geo/platforms/GPLnnn/GPL570/annot/GPL570.annot.gz" title="Contains up-to-date gene annotation for the DataSet Platform (plain text, tab-delimited format)." class="annotation-soft">
Annotation SOFT file
</a></li></ul></fieldset></td></tr><tr><th scope="row" class="not_caption">
Summary:
</th><td colspan="3">Analysis of HPB-ALL and KOPT-K1 cells treated with SAHM1, an antagonist of the NOTCH transcription factor. SAHM1 is an alpha-helical hydrocarbon stapled peptide derived from MAML1. Results provide insight into the specificity of the antagonistic effect of SAHM1 on gene expression driven by NOTCH.</td></tr><tr><th scope="row" class="not_caption">Organism:
</th><td colspan="3" class="species"><a target="_blank" href="/Taxonomy/Browser/wwwtax.cgi?mode=Undef&amp;lvl=0&amp;srchmode=1&amp;name=Homo%20sapiens">Homo sapiens</a></td></tr><tr><th scope="row" class="not_caption">
Platform:
</th><td colspan="3"><a href="/geo/query/acc.cgi?acc=GPL570" target="_blank">
GPL570</a>:
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array</td></tr><tr><th scope="row" class="not_caption">Citation:</th><td colspan="3"><div class="PubmedCitation"><ul><li><span class="authors">Moellering RE, Cornejo M, Davis TN, Del Bianco C et al. </span><span class="title">Direct inhibition of the NOTCH transcription factor complex. </span><span class="source">Nature</span> 2009 Nov 12;462(7270):182-8. PMID: <a title="Link to PubMed record" href="https://www.ncbi.nlm.nih.gov/pubmed/19907488">19907488</a></li></ul></div></td></tr><tr><th scope="row" class="not_caption">
Reference Series:
</th><td><a href="/geo/query/acc.cgi?acc=GSE18198" target="_blank">
GSE18198</a></td><th id="samp-cnt" class="not_caption">
Sample count:
</th><td>12</td></tr><tr><th scope="row" class="not_caption">
Value type:
</th><td>transformed count</td><th id="series-pub" class="not_caption">
Series published:
</th><td>2009/11/12</td></tr></table><div id="divExtra"></div></div>
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