237 lines
9 KiB
HTML
237 lines
9 KiB
HTML
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<!DOCTYPE html>
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<html>
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<head>
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<title>Genome Reference Consortium</title>
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<meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
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<meta name="ncbi_app" content="grc" />
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<meta name="ncbi_db" content="none" />
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<meta name="ncbi_pdid" content="screen_default" />
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<meta name="ncbi_pagename" content="home" />
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<meta name="ncbi_pagetitle" content="Genome Reference Consortium" />
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<link rel="stylesheet" type="text/css" href="/grc/static/grc/css/grc.css" />
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<style>
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#menu ul#primary a#homeMenuItem {
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border: 1px solid #666;
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border-bottom: none;
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background: #333;
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padding-bottom: 6px;
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margin-top: 0;
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color: #ff9933;
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text-decoration: none;
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}
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#menu ul#secondary li a#home-MenuItem {
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color: #EFEFEF;
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}
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</style>
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<link rel="stylesheet" type="text/css" href="/core/jig/1.14.8/css/jig.min.css" />
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<script type="text/javascript" src="/core/jig/1.14.8/js/jig.min.js"></script>
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<script type="text/javascript" src="/grc/static/grc/js/grc.js"></script>
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</head>
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<body>
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<noscript>
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<p>
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<b>Warning:</b> this web site requires JavaScript to function. <a href="/guide/browsers#js_settings">more...</a>
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</p>
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</noscript>
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<div id="header-container">
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<a href="/grc">
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<div id="header">
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<img alt="GRC logo" src="/grc/static/grc/img/GRC_logo_reasonably_small.png" /><img src="/grc/static/grc/img/TitleBanner.png" alt="Genome Reference Consortium" /></a>
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</div>
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</div>
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<div id="page">
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<a id="skipnav" href="#main">Skip navigation and go to main content</a>
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<div id="menu">
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<ul id="primary">
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<li><a href="/grc" title="GRC home" id="homeMenuItem">GRC Home</a></li>
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<li><a href="/grc/data" title="Data" id="dataMenuItem">Data</a>
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<ul id="secondary">
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<li><a href="/grc/human" title="Human genome overview page">Human</a></li>
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<li><a href="/grc/mouse" title="Mouse genome overview page">Mouse</a></li>
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<li><a href="/grc/zebrafish" title="Zebrafish genome overview page">Zebrafish</a></li>
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<li><a href="/grc/rat" title="Rat genome overview page">Rat</a></li>
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<li><a href="/grc/chicken" title="Chicken genome overview page">Chicken</a></li>
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</ul>
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</li>
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<li><a href="/grc/help" title="Information and help" id="helpMenuItem">Help</a></li>
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<li><a href="/grc/report-an-issue" title="Report a problem" id="reportAnIssueMenuItem">Report an Issue</a></li>
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<li><a href="/grc/contact-us" title="contact us" id="contactUsMenuItem">Contact Us</a></li>
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<li><a href="/grc/credits" title="credits" id="creditsMenuItem">Credits</a></li>
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<li><a href="/projects/genome/assembly/grc/curation" title="Curators only, authentication required" id="curatorsOnlyMenuItem">Curators Only</a></li>
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</ul>
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</div><!--end menu-->
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<div id="main"><a name="main"></a>
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<div id="home">
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<div id="contents" style="overflow:hidden;">
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<div id="right_col">
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<div id="news" class="widget">
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<h3>
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<a href='http://genomeref.blogspot.com' target='_blank'>GRC News</a>
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</h3>
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<div id="news_items" class="content">
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<p class="issue_date">Feb 02, 2024</p>
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<h4><a href="http://genomeref.blogspot.com/2024/02/grcr8-new-rat-reference-assembly-is.html" title="View blog post" target="_blank">GRCr8: A new rat reference assembly is released!</a></h4>
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<br/>
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<p class="issue_date">May 09, 2022</p>
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<h4><a href="http://genomeref.blogspot.com/2022/05/grch38p14-is-now-released.html" title="View blog post" target="_blank">GRCh38.p14 is now released!</a></h4>
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<a href="http://genomeref.blogspot.com" class="more" title="View GRC blog">see all</a>
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</div>
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</div>
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<div id="resolved" class="widget" style="display: none;">
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<h3>
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Resolved Issues
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</h3>
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<div class="content" id="res_issues">
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<p class="issue_date">Oct 8, 2024</p>
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<span class="res_issues_summary">
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Rat:
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<a href="/grc/rat/issues/RG-243">RG-243</a>
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</span>
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<div class="res_text">
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<p>unknown</p>
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</div>
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<p class="issue_date">Aug 8, 2024</p>
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<span class="res_issues_summary">
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Rat:
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<a href="/grc/rat/issues/RG-25">RG-25</a>
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</span>
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<div class="res_text">
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<p>gene sequence error resolved in GRCr8 assembly</p>
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</div>
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</div>
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</div>
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</div>
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<h1>The Genome Reference Consortium</h1>
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<p class="subtitle">Putting sequences into a chromosome context</p>
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<p>
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The original model for representing the genome assemblies was to use a single, preferred tiling path to produce a
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single consensus representation of the genome. Subsequent analysis has shown that for most mammalian genomes a
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single tiling path is insufficient to represent a genome in regions with complex allelic diversity. The GRC is
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now working to create assemblies that better represent this diversity and provide more robust substrates for genome
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analysis.
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<p class="announce">Slides from GRC presentations in 2019 are now on <a href="https://www.slideshare.net/GenomeRef">SlideShare</a></p>
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<p class="announce">The GRC released GRCh38.p14, a non-coordinate changing update to the human reference assembly in May 2022. See our <a href="https://genomeref.blogspot.com/2022/05/grch38p14-is-now-released.html">blog post</a> for more information.</p>
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<p class="announce">The GRC remains committed to its mission to improve the human reference genome assembly, correcting errors and adding sequence to ensure it provides the best representation of the human genome to meet basic and clinical research needs. We will continue to make these updates publicly available at regular intervals in the form of patch releases, but have decided to indefinitely postpone our next coordinate-changing update (GRCh39) while we evaluate new models and sequence content from ongoing efforts to better represent the genetic diversity of the human pangenome, including those of the Telemore-to-Telomere Consortium and the Human Pangenome Reference Consortium.</p>
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<p class="announce"><a href="https://www.ncbi.nlm.nih.gov/mailman/listinfo/grc-announce">Subscribe</a> to the grc-announce email list to receive email notification for all GRC assembly updates.</p>
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<div id="consortium">
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<h3>The Genome Reference Consortium consists of:</h3>
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<dl>
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<dt>
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<a href="https://www.sanger.ac.uk/research/areas/bioinformatics/grc" target="_blank">
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<img src="/grc/static/grc/img/Sanger_GRC.png" alt="Sanger logo" />
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</a>
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</dt>
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<dd>
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<a href="https://www.sanger.ac.uk/research/areas/bioinformatics/grc" target="_blank">Wellcome Sanger Institute</a>
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</dd>
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<dt>
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<a href="http://genome.wustl.edu" target="_blank">
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<img src="/grc/static/grc/img/MGI_WashU_Logo_GRC.png" alt="The McDonnell Genome Institute at Washington University"/>
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</a>
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</dt>
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<dd>
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<a href="http://genome.wustl.edu" target="_blank">The McDonnell Genome Institute at Washington University</a>
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</dd>
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<dt>
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<a href="https://www.ebi.ac.uk" target="_blank">
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<img src="/grc/static/grc/img/EMBL_EBI_CMYK_2012_GRC.png" alt="EBI logo" />
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</a>
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</dt>
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<dd>
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<a href="https://www.ebi.ac.uk" target="_blank">The European Bioinformatics Institute</a>
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</dd>
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<dt>
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<a href="https://www.ncbi.nlm.nih.gov" target="_blank">
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<img src="/grc/static/grc/img/NCBI_GRC.png" alt="NCBI logo" />
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</a>
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</dt>
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<dd>
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<a href="https://www.ncbi.nlm.nih.gov" target="_blank">The National Center for Biotechnology Information</a>
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</dd>
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<dt>
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<a href="http://zfin.org" target="_blank" class="center-fill">
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<img src="/grc/static/grc/img/ZFIN_logo.png" alt="ZFIN logo" />
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</a>
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</dt>
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<dd>
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<a href="http://zfin.org" target="_blank">The Zebrafish Model Organism Database</a>
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</dd>
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<dt>
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<a href="https://rgd.mcw.edu/" target="_blank" class="center-fill">
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<img src="/grc/static/grc/img/RGD_MCW_Logo_GRC.png" alt="Rat Genome Database"/>
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</a>
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</dt>
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<dd>
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<a href="https://rgd.mcw.edu/" target="_blank">Rat Genome Database</a>
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</dd>
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</dl>
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</div>
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</div>
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<div class="cleaner"></div>
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</div>
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</div>
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<div class="cleaner"></div>
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<div id="footer">
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<ul>
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<li><a title="Get GRC data via FTP" href="https://ftp.ncbi.nlm.nih.gov/pub/grc/">FTP</a></li>
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<li><a target="_blank" href="https://www.genome.gov">NHGRI</a></li>
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<li><a target="_blank" href="http://www.wellcome.ac.uk">Wellcome Sanger Institute</a></li>
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<li><a target="_blank" href="https://www.hhs.gov">HHS</a></li>
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<li><a target="_blank" href="https://www.nih.gov">NIH</a></li>
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<li><a target="_blank" href="https://www.nih.gov/web-policies-notices">Accessibility</a></li>
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<li class="last"><a target="_blank" href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html">HHS Vulnerability Disclosure</a></li>
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</ul>
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</div>
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</div>
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</div><!-- end page -->
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<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js"></script>
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</body>
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