63 lines
1.7 KiB
HTML
63 lines
1.7 KiB
HTML
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<link rel=Edit-Time-Data href="Hetfreq_files/editdata.mso">
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<title>dbSNP:Computation of Average Heterozygosity</title>
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<table width="620">
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<td><h4><font face="Helvetica,Arial" color="083194">Computation of Average
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Heterozygosity and Standard Error for dbSNP RefSNP Clusters</font></h4>
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<h5><font face="Helvetica,Arial" color="083194">John Spouge, Lon Phan,
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and Stephen Sherry<br>
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NCBI, 2000-2002<br>
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</font></h5></td>
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</tr>
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<td><p><font face="Arial,Helvetica" color="404040">Average heterozygosity
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is computed for each refSNP cluster based on all the variation data
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submitted
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for ss# members. There are three types of variation data in dbSNP: direct
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measures of heterozygosity in a sample, "binned" allele frequency
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estimates
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that can only be resolved to a small number of classes, and point estimates
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based on moderate to large sample sizes. Estimates of heterozygosity
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are
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computed for each class and then summed with each term weighted by its
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standard error. This produces a linear estimate of <em>h</em> with
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minimum variance. </font></p></td>
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</tr>
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</table>
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<img name="hetfreqform" src="hetfreqform.gif" width="640" height="1321" border="0" alt="">
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