598 lines
No EOL
116 KiB
XML
598 lines
No EOL
116 KiB
XML
<?xml version="1.0" encoding="utf-8"?>
|
||
<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
|
||
<html xmlns="http://www.w3.org/1999/xhtml" lang="en" xml:lang="en">
|
||
<head xmlns:xi="http://www.w3.org/2001/XInclude"><meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
|
||
<!-- meta -->
|
||
<meta name="robots" content="noindex,nofollow,noarchive" />
|
||
<meta name="ncbi_app" content="entrez" /><meta name="ncbi_db" content="pmc" /><meta name="ncbi_term" content=""expert opin orphan drugs"[jour]" /><meta name="ncbi_report" content="docsum" /><meta name="ncbi_format" content="html" /><meta name="ncbi_pagesize" content="20" /><meta name="ncbi_sortorder" content="default" /><meta name="ncbi_pageno" content="1" /><meta name="ncbi_resultcount" content="54" /><meta name="ncbi_op" content="search" /><meta name="ncbi_pdid" content="docsum" /><meta name="ncbi_sessionid" content="CE8BC1E97D9F05E1_0182SID" /><meta name="ncbi_filter" content="all" /><meta name="ncbi_stat" content="false" /><meta name="ncbi_hitstat" content="false" />
|
||
|
||
|
||
<!-- title -->
|
||
<title>"Expert Opin Orphan Drugs"[jour] - PMC - NCBI</title>
|
||
|
||
<!-- Common JS and CSS -->
|
||
|
||
<script type="text/javascript">
|
||
var ncbi_startTime = new Date();
|
||
</script>
|
||
<script type="text/javascript" src="https://static.pubmed.gov/core/jig/1.15.3/js/jig.min.js"></script><link rel="stylesheet" href="/corehtml/pmc/css/3.18/pmc.min.css" type="text/css" /><style type="text/css">.pmc-wm {background:transparent repeat-y top left;background-image:url(/corehtml/pmc/pmcgifs/wm-journal.gif);background-size: auto, contain}</style><style type="text/css">.print-view{display:block}</style><script>
|
||
var isjq= typeof jQuery === "function"
|
||
</script><script type="text/javascript">if (!isjq){document.write('\x3Cscript type="text/javascript" src="/core/jig/1.15.2/js/jig.min.js"\x3E\x3C/script\x3E')}{document.write('\x3Cscript type="text/javascript" src="/core/jig/1.15.2/js/jig.nojquery.min.js"\x3E\x3C/script\x3E')}</script><script type="text/javascript" src="/corehtml/pmc/js/common.min.js?_=3.18">//</script><script type="text/javascript" src="/corehtml/pmc/js/NcbiTagServer.min.js?_=3.18">//</script><script type="text/javascript">window.name="mainwindow";</script>
|
||
|
||
<link type="text/css" href="/corehtml/pmc/css/figpopup.css" rel="stylesheet" />
|
||
<script type="text/javascript" src="/corehtml/pmc/js/figpopup.min.js"></script>
|
||
|
||
|
||
|
||
<link xmlns="http://www.w3.org/1999/xhtml" type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4218191/css/4207974/4206132.css" xml:base="http://127.0.0.1/sites/static/header_footer/" />
|
||
<link rel="shortcut icon" href="//www.ncbi.nlm.nih.gov/favicon.ico" /><meta name="ncbi_phid" content="CE8D05537DC158610000000000860078.m_16" /><script type="text/javascript"><!--
|
||
var ScriptPath = '/portal/';
|
||
var objHierarchy = {"name":"EntrezSystem2","type":"Layout","realname":"EntrezSystem2",
|
||
"children":[{"name":"EntrezSystem2.PEntrez","type":"Cluster","realname":"EntrezSystem2.PEntrez",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.DbConnector","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.DbConnector","shortname":"DbConnector"},
|
||
{"name":"EntrezSystem2.PEntrez.ParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.ParamContainer","shortname":"ParamContainer"},
|
||
{"name":"EntrezSystem2.PEntrez.MyNcbi","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.MyNcbi","shortname":"MyNcbi"},
|
||
{"name":"EntrezSystem2.PEntrez.UserPreferenceUrlParamContainer","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.UserPreferenceUrlParamContainer","shortname":"UserPreferenceUrlParamContainer"},
|
||
{"name":"EntrezSystem2.PEntrez.GridProperty","type":"Portlet","realname":"EntrezSystem2.PEntrez.PEntrez.GridProperty","shortname":"GridProperty"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC","type":"Cluster","realname":"EntrezSystem2.PEntrez.PMC",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.PMC.NoPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NoPortlet","shortname":"NoPortlet"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_PageController","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_PageController","shortname":"Pmc_PageController"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_SearchBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_SearchBar","shortname":"Pmc_SearchBar"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Entrez_BotRequest","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.Entrez_BotRequest","shortname":"Entrez_BotRequest"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Entrez_LimitsTab","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.Entrez_LimitsTab","shortname":"Entrez_LimitsTab"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Facets","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Facets","shortname":"Facets"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Entrez_Clipboard","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.Entrez_Clipboard","shortname":"Entrez_Clipboard"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_StaticParts","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_StaticParts","shortname":"Pmc_StaticParts"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Entrez_Messages","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.Entrez_Messages","shortname":"Entrez_Messages"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.NcbiJSCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NcbiJSCheck","shortname":"NcbiJSCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NCBIFooter_dynamic",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.PMC.NCBIFooter_dynamic.Footer_ExtraData","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NCBIFooter_dynamic.Footer_ExtraData","shortname":"Footer_ExtraData"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.NCBIFooter_dynamic.NCBIFooter_dynamic","type":"Cluster","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.PMC.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIBreadcrumbs","shortname":"NCBIBreadcrumbs"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIHelpDesk","shortname":"NCBIHelpDesk"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Entrez_Database.NCBIFooter_dynamic.NCBIFooter_dynamic.NCBIApplog_NoScript_Ping","shortname":"NCBIApplog_NoScript_Ping"}]}]},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.HelpDesk","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.HelpDesk","shortname":"HelpDesk"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel","type":"Cluster","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.blankToolPanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.blankToolPanel","shortname":"blankToolPanel"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_ResultsSearchController","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_ResultsSearchController","shortname":"Pmc_ResultsSearchController"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab","shortname":"Pmc_FilterTab"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.Entrez_Pager","shortname":"Entrez_Pager"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar","shortname":"Pmc_DisplayBar"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HelpFormAttributes","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.HelpFormAttributes","shortname":"HelpFormAttributes"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Collections","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.Entrez_Collections","shortname":"Entrez_Collections"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.SpellCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.SpellCheck","shortname":"SpellCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.SearchEngineReferralCheck","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.SearchEngineReferralCheck","shortname":"SearchEngineReferralCheck"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.MultiSensorPortlet","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.MultiSensorPortlet","shortname":"MultiSensorPortlet"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.WrongDbSensor","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.WrongDbSensor","shortname":"WrongDbSensor"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.KnowledgePanel","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.KnowledgePanel","shortname":"KnowledgePanel"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.HistoryDisplay","shortname":"HistoryDisplay"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_ResultsPanel.Discovery_SearchDetails","shortname":"Discovery_SearchDetails"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab","shortname":"EmailTab"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum","shortname":"Pmc_RVDocSum"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl","type":"Cluster","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl",
|
||
"children":[{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks","shortname":"Pmc_RelatedDataLinks"},
|
||
{"name":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_ImageAd","type":"Portlet","realname":"EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_ImageAd","shortname":"Pmc_ImageAd"}]}]}]}]}]};
|
||
--></script>
|
||
<meta name='referrer' content='origin-when-cross-origin'/><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4213537/css/3808861/3917732/3974050/3751656/3395415/3846471/4213536/4062871/4195405/4186458/4075711/4211954/3577051/3858295/12930/4033350/4128070/3861632/4080092/9685/3327433/648426/3357701/3395586.css" /><link type="text/css" rel="stylesheet" href="//static.pubmed.gov/portal/portal3rc.fcgi/4213537/css/3501913/1303451/3529739.css" media="print" /><script type="text/javascript">
|
||
|
||
var ObjectLinks=[{i:0, ename: "p$ExL", esid:"*", sname: "p$ExL", ssid:"*", dname:"p$el", dsid:"0",m:"CopyValue",p:[],f: function(src, dst) {fn_CopyValue(src, dst);}}]
|
||
|
||
|
||
var ActiveNames = {"p$ExL":1, "EntrezSystem2.PEntrez.DbConnector.Cmd":0, "EntrezSystem2.PEntrez.DbConnector.Db":0, "EntrezSystem2.PEntrez.DbConnector.IdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastDb":0, "EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult":0, "EntrezSystem2.PEntrez.DbConnector.LastQueryKey":0, "EntrezSystem2.PEntrez.DbConnector.LastTabCmd":0, "EntrezSystem2.PEntrez.DbConnector.LinkName":0, "EntrezSystem2.PEntrez.DbConnector.LinkReadableName":0, "EntrezSystem2.PEntrez.DbConnector.LinkSrcDb":0, "EntrezSystem2.PEntrez.DbConnector.QueryKey":0, "EntrezSystem2.PEntrez.DbConnector.TabCmd":0, "EntrezSystem2.PEntrez.DbConnector.Term":0, "EntrezSystem2.PEntrez.PMC.Facets.BMFacets":0, "EntrezSystem2.PEntrez.PMC.Facets.FacetSubmitted":0, "EntrezSystem2.PEntrez.PMC.Facets.FacetsUrlFrag":0, "EntrezSystem2.PEntrez.PMC.Pmc_PageController.PreviousPageName":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails.SearchDetailsQuery":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails.SearchDetailsTerm":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails.Shutter":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Answer":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Email":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailCount":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailFormat":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailHID":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailQueryKey":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailReport":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailSort":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailStart":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailSubject":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailText":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Holding":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.HoldingFft":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.HoldingNdiSet":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Key":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.OToolValue":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.QueryDescription":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.SubjectList":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.CurrPage":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.cPage":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.ClearHistory":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.Cmd":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryOn":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryToggle":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.Shutter":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FFormat":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FFormat2":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FSort":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FSort2":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FileFormat":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FileSort":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Format":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastFormat":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastPageSize":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastPresentation":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastSort":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.PageSize":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Presentation":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SetDisplay":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Sort":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize2":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation2":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort2":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab.CurrFilter":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab.Filter":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab.LastFilter":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.DbName":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.Shutter":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.rdDatabase":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.rdFind":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.rdLinkOption":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_ResultsSearchController.ResultCount":0, "EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_ResultsSearchController.RunLastQuery":0};
|
||
</script></head>
|
||
<body>
|
||
<div class="grid">
|
||
<div class="col twelve_col nomargin shadow">
|
||
<form enctype="application/x-www-form-urlencoded" name="EntrezForm" method="post" onsubmit="return false;" action="/pmc" id="EntrezForm">
|
||
<div xmlns:xi="http://www.w3.org/2001/XInclude">
|
||
<!-- no javascript message -->
|
||
|
||
|
||
<div xmlns="http://www.w3.org/1999/xhtml" id="universal_header" xml:base="http://127.0.0.1/sites/static/header_footer/">
|
||
<section class="usa-banner">
|
||
<div class="usa-accordion">
|
||
<header class="usa-banner-header">
|
||
<div class="usa-grid usa-banner-inner">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png" alt="U.S. flag" />
|
||
<p>An official website of the United States government</p>
|
||
<button class="non-usa-accordion-button usa-banner-button" aria-expanded="false" aria-controls="gov-banner-top" type="button">
|
||
<span class="usa-banner-button-text">Here's how you know</span>
|
||
</button>
|
||
</div>
|
||
</header>
|
||
<div class="usa-banner-content usa-grid usa-accordion-content" id="gov-banner-top" aria-hidden="true">
|
||
<div class="usa-banner-guidance-gov usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg" alt="Dot gov" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The .gov means it's official.</strong>
|
||
<br />
|
||
Federal government websites often end in .gov or .mil. Before
|
||
sharing sensitive information, make sure you're on a federal
|
||
government site.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
<div class="usa-banner-guidance-ssl usa-width-one-half">
|
||
<img class="usa-banner-icon usa-media_block-img" src="https://www.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg" alt="Https" />
|
||
<div class="usa-media_block-body">
|
||
<p>
|
||
<strong>The site is secure.</strong>
|
||
<br />
|
||
The <strong>https://</strong> ensures that you are connecting to the
|
||
official website and that any information you provide is encrypted
|
||
and transmitted securely.
|
||
</p>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<div class="usa-overlay"></div>
|
||
<header class="ncbi-header" role="banner" data-section="Header">
|
||
|
||
<div class="usa-grid">
|
||
<div class="usa-width-one-whole">
|
||
|
||
<div class="ncbi-header__logo">
|
||
<a href="/" class="logo" aria-label="NCBI Logo" data-ga-action="click_image" data-ga-label="NIH NLM Logo">
|
||
<img src="https://www.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg" alt="NIH NLM Logo" />
|
||
</a>
|
||
</div>
|
||
|
||
<div class="ncbi-header__account">
|
||
<a id="account_login" href="https://account.ncbi.nlm.nih.gov" class="usa-button header-button" style="display:none" data-ga-action="open_menu" data-ga-label="account_menu">Log in</a>
|
||
<button id="account_info" class="header-button" style="display:none" aria-controls="account_popup" type="button">
|
||
<span class="fa fa-user" aria-hidden="true">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" width="20px" height="20px">
|
||
<g style="fill: #fff">
|
||
<ellipse cx="12" cy="8" rx="5" ry="6"></ellipse>
|
||
<path d="M21.8,19.1c-0.9-1.8-2.6-3.3-4.8-4.2c-0.6-0.2-1.3-0.2-1.8,0.1c-1,0.6-2,0.9-3.2,0.9s-2.2-0.3-3.2-0.9 C8.3,14.8,7.6,14.7,7,15c-2.2,0.9-3.9,2.4-4.8,4.2C1.5,20.5,2.6,22,4.1,22h15.8C21.4,22,22.5,20.5,21.8,19.1z"></path>
|
||
</g>
|
||
</svg>
|
||
</span>
|
||
<span class="username desktop-only" aria-hidden="true" id="uname_short"></span>
|
||
<span class="sr-only">Show account info</span>
|
||
</button>
|
||
</div>
|
||
|
||
<div class="ncbi-popup-anchor">
|
||
<div class="ncbi-popup account-popup" id="account_popup" aria-hidden="true">
|
||
<div class="ncbi-popup-head">
|
||
<button class="ncbi-close-button" data-ga-action="close_menu" data-ga-label="account_menu" type="button">
|
||
<span class="fa fa-times">
|
||
<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 48 48" width="24px" height="24px">
|
||
<path d="M38 12.83l-2.83-2.83-11.17 11.17-11.17-11.17-2.83 2.83 11.17 11.17-11.17 11.17 2.83 2.83 11.17-11.17 11.17 11.17 2.83-2.83-11.17-11.17z"></path>
|
||
</svg>
|
||
</span>
|
||
<span class="usa-sr-only">Close</span></button>
|
||
<h4>Account</h4>
|
||
</div>
|
||
<div class="account-user-info">
|
||
Logged in as:<br />
|
||
<b><span class="username" id="uname_long">username</span></b>
|
||
</div>
|
||
<div class="account-links">
|
||
<ul class="usa-unstyled-list">
|
||
<li><a id="account_myncbi" href="/myncbi/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_myncbi">Dashboard</a></li>
|
||
<li><a id="account_pubs" href="/myncbi/collections/bibliography/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_pubs">Publications</a></li>
|
||
<li><a id="account_settings" href="/account/settings/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_settings">Account settings</a></li>
|
||
<li><a id="account_logout" href="/account/signout/" class="set-base-url" data-ga-action="click_menu_item" data-ga-label="account_logout">Log out</a></li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
</header>
|
||
<div role="navigation" aria-label="access keys">
|
||
<a id="nws_header_accesskey_0" href="https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys" class="usa-sr-only" accesskey="0" tabindex="-1">Access keys</a>
|
||
<a id="nws_header_accesskey_1" href="https://www.ncbi.nlm.nih.gov" class="usa-sr-only" accesskey="1" tabindex="-1">NCBI Homepage</a>
|
||
<a id="nws_header_accesskey_2" href="/myncbi/" class="set-base-url usa-sr-only" accesskey="2" tabindex="-1">MyNCBI Homepage</a>
|
||
<a id="nws_header_accesskey_3" href="#maincontent" class="usa-sr-only" accesskey="3" tabindex="-1">Main Content</a>
|
||
<a id="nws_header_accesskey_4" href="#" class="usa-sr-only" accesskey="4" tabindex="-1">Main Navigation</a>
|
||
</div>
|
||
<section data-section="Alerts">
|
||
<div class="ncbi-alerts-placeholder"></div>
|
||
</section>
|
||
</div>
|
||
|
||
<div class="header">
|
||
<!-- logo -->
|
||
<div class="res_logo">
|
||
<h1 class="img_logo"><a href="/pmc/" class="pmc_logo offscreen">PMC</a></h1>
|
||
<div class="NLMLogo">
|
||
<a href="https://www.nlm.nih.gov/" title="US National Library of Medicine">US National Library of Medicine</a>
|
||
<br />
|
||
<a href="https://www.nih.gov/" title="National Institutes of Health">National Institutes of Health</a>
|
||
</div>
|
||
</div>
|
||
<!-- SearchBar -->
|
||
<div class="search"><div class="search_form"><label for="database" class="offscreen_noflow">Search database</label><select id="database"><optgroup label="Recent"><option value="pmc" selected="selected" data-ac_dict="pmc-search-autocomplete">PMC</option><option value="nuccore">Nucleotide</option><option value="books">Books</option><option value="omim" class="last">OMIM</option></optgroup><optgroup label="All"><option value="gquery">All Databases</option><option value="assembly">Assembly</option><option value="biocollections">Biocollections</option><option value="bioproject">BioProject</option><option value="biosample">BioSample</option><option value="books">Books</option><option value="clinvar">ClinVar</option><option value="cdd">Conserved Domains</option><option value="gap">dbGaP</option><option value="dbvar">dbVar</option><option value="gene">Gene</option><option value="genome">Genome</option><option value="gds">GEO DataSets</option><option value="geoprofiles">GEO Profiles</option><option value="gtr">GTR</option><option value="ipg">Identical Protein Groups</option><option value="medgen" data-ac_dict="medgen_disease_name">MedGen</option><option value="mesh" data-ac_dict="mesh_suggestions">MeSH</option><option value="nlmcatalog">NLM Catalog</option><option value="nuccore">Nucleotide</option><option value="omim">OMIM</option><option value="pmc" data-ac_dict="pmc-search-autocomplete">PMC</option><option value="protein">Protein</option><option value="proteinclusters">Protein Clusters</option><option value="protfam">Protein Family Models</option><option value="pcassay">PubChem BioAssay</option><option value="pccompound">PubChem Compound</option><option value="pcsubstance">PubChem Substance</option><option value="pubmed" data-ac_dict="pm_related_queries_2">PubMed</option><option value="snp">SNP</option><option value="sra">SRA</option><option value="structure">Structure</option><option value="taxonomy">Taxonomy</option><option value="toolkit">ToolKit</option><option value="toolkitall">ToolKitAll</option><option value="toolkitbookgh">ToolKitBookgh</option></optgroup></select><div class="nowrap"><label for="term" class="offscreen_noflow" accesskey="/">Search term</label><div class="nowrap"><input type="text" name="term" id="term" title="Search PMC. Use up and down arrows to choose an item from the autocomplete." value=""Expert Opin Orphan Drugs"[jour]" class="jig-ncbiclearbutton jig-ncbiautocomplete" data-jigconfig="dictionary:'pmc-search-autocomplete',disableUrl:'NcbiSearchBarAutoComplCtrl'" autocomplete="off" data-sbconfig="ds:'no',pjs:'yes',afs:'yes'" /></div><button id="search" type="submit" class="button_search nowrap" cmd="go">Search</button></div></div><ul class="searchlinks inline_list"><set></set><li><a name="SaveSearch" title="Click to create an email alert for this search" href="/sites/myncbi/searches/save?db=pmc&qk=90019" id="SaveSearch">Create alert</a></li><li><a href="/pmc/journals/">Journal List</a></li><li><a href="/pmc/advanced">Advanced</a></li><li class="help"><a id="help" class="jig-ncbihelpwindow" target="ncbihelp" name="help" href="/books/NBK3825">Help</a></li></ul></div>
|
||
</div>
|
||
|
||
<input name="EntrezSystem2.PEntrez.PMC.Pmc_PageController.PreviousPageName" sid="1" type="hidden" value="results" />
|
||
<div class="hidden-email">
|
||
<div><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailReport" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailFormat" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailCount" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailStart" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailSort" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Email" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailSubject" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailText" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailQueryKey" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.EmailHID" sid="1" type="hidden" value="167i_h-Iu4Tqwj2-Xxba7WpW9wMrv7aBdvxhskgw3U" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.QueryDescription" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Key" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Answer" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.Holding" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.HoldingFft" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.HoldingNdiSet" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.OToolValue" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.EmailTab.SubjectList" sid="1" type="hidden" value="" /></div><!-- hidden inputs -->
|
||
</div>
|
||
<div id="faceted_search" class="col two_col">
|
||
<h2 class="offscreen_noflow">Result Filters</h2>
|
||
<div class="facet_cont" data-db="pmc" data-default_grps="fg_types,fg_text_availability,fg_pubdate,fg_funding" data-sd="db:'pmc',op:'search',term:'%22Expert%20Opin%20Orphan%20Drugs%22%5Bjour%5D',qk:'90019',linkname:'',idsfromresult:'',extra:''"><ul class="facet" data-filter_id="types" id="_types"><li class="filter_grp "><div class="clearfix"><h3>Article attributes</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="associateddata">Associated Data</a></li><li class="fil_val"><a href="#" data-value_id="manuscripts">Author manuscripts</a></li><li class="fil_val"><a href="#" data-value_id="digitazed">Digitized back issues</a></li><li class="fil_val"><a href="#" data-value_id="medline">MEDLINE journals</a></li><li class="fil_val"><a href="#" data-value_id="openaccess">Open access</a></li><li class="fil_val"><a href="#" data-value_id="preprint">Preprints</a></li><li class="fil_val"><a href="#" data-value_id="retracted">Retracted</a></li></ul></li></ul><ul class="facet" data-filter_id="text_availability" id="_text_availability"><li class="filter_grp "><div class="clearfix"><h3>Text availability</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="embargoed">Include embargoed articles</a></li></ul></li></ul><ul class="facet" data-filter_id="pubdate" data-ds="yes" id="_pubdate"><li class="filter_grp"><div class="clearfix"><h3>Publication date</h3><a href="#" data-value_id="" class="clear clear_hide">clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="y_1">1 year</a></li><li class="fil_val"><a href="#" data-value_id="y_5">5 years</a></li><li class="fil_val"><a href="#" data-value_id="y_10">10 years</a></li><li class="daterange"><a id="facet_date_rangepubdate" href="#facet_date_range_divpubdate" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'middle left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '375px'">
|
||
Custom range...</a></li><div id="facet_date_range_divpubdate" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Custom date range</h4><div><label class="offscreen_noflow" for="facet_date_st_yearpubdate">Start Year</label><input type="text" size="4" placeholder="YYYY" id="facet_date_st_yearpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_st_monthpubdate">Start Month</label><input type="text" size="2" placeholder="MM" id="facet_date_st_monthpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_st_daypubdate">Start Day</label><input type="text" size="2" placeholder="DD" id="facet_date_st_daypubdate" value="" /><span>to</span><label class="offscreen_noflow" for="facet_date_end_yearpubdate">End Year</label><input type="text" size="4" placeholder="YYYY" id="facet_date_end_yearpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_end_monthpubdate">End Month</label><input type="text" size="2" placeholder="MM" id="facet_date_end_monthpubdate" value="" class="input_date_ym" /><label class="offscreen_noflow" for="facet_date_end_daypubdate">End Day</label><input type="text" size="2" placeholder="DD" id="facet_date_end_daypubdate" value="" /></div><div class="actions clearfix"><button class="jig-ncbibutton primary-action btn_date_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'" id="facet_date_range_applypubdate">Apply</button><button class="jig-ncbibutton secondary-action btn_date_clear" data-jigconfig="'color': 'ui-ncbibutton-gray'" id="facet_date_range_clearpubdate">Clear</button></div></div></ul></li></ul><ul class="facet" data-filter_id="funding" id="_funding"><li class="filter_grp "><div class="clearfix"><h3>Research Funder</h3><a href="#" data-value_id="" class="clear clear_hide">Clear</a></div><ul><li class="fil_val"><a href="#" data-value_id="funder_nih">NIH</a></li><li class="fil_val"><a href="#" data-value_id="funder_ahrq">AHRQ</a></li><li class="fil_val"><a href="#" data-value_id="funder_acl">ACL</a></li><li class="fil_val"><a href="#" data-value_id="funder_aspr">ASPR</a></li><li class="fil_val"><a href="#" data-value_id="funder_cdc">CDC</a></li><li class="fil_val"><a href="#" data-value_id="funder_dhs">DHS</a></li><li class="fil_val"><a href="#" data-value_id="funder_epa">EPA</a></li><li class="fil_val"><a href="#" data-value_id="funder_fda">FDA</a></li><li class="fil_val"><a href="#" data-value_id="funder_nasa">NASA</a></li><li class="fil_val"><a href="#" data-value_id="funder_nist">NIST</a></li><li class="fil_val"><a href="#" data-value_id="funder_va">VA</a></li><li class="more"><a href="#funding_more" data-value_id="fetch_more" data-jigconfig=" hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '300px'">Customize ...</a><div style="display:none;" id="funding_more"></div></li></ul></li></ul><ul class="facet facet_reset"><li><a href="#" data-value_id="reset">Clear all</a></li></ul><ul class="facet_tools"><li><a id="more_filter_groups_link" href="#more_filter_groups" class="jig-ncbipopper" data-jigconfig="triggerPosition: 'middle right', destPosition: 'top left', hasArrow: true, arrowDirection: 'left', closeEvent : 'click', openEvent: 'click', adjustFit: 'autoAdjust', openAnimation: 'none', closeAnimation: 'none', addCloseButton:true, width: '180px'">
|
||
Show additional filters</a></li><div id="more_filter_groups" style="display:none;" class="facets_dialog"><button class="ui-ncbipopper-close-button ui-ncbipopper-close-button-generated ui-state-default ui-corner-all ui-button-text-only ui-ncbibutton ui-ncbibutton-blue" generated="true" role="button" aria-disabled="false"><span class="ui-button-text">x</span></button><h4>Additional filters</h4><ul class="filter_groups_more facet"><li><input type="checkbox" id="fg_types" /><label for="fg_types">Article attributes</label></li><li><input type="checkbox" id="fg_text_availability" /><label for="fg_text_availability">Text availability</label></li><li><input type="checkbox" id="fg_pubdate" data-always_show="yes" /><label for="fg_pubdate">Publication date</label></li><li><input type="checkbox" id="fg_funding" data-always_show="yes" /><label for="fg_funding">Research Funder</label></li><li><input id="fg_field_search" type="checkbox" /><label for="fg_field_search">Search fields</label></li></ul><div class="actions clearfix"><button class="filter_groups_more_apply jig-ncbibutton primary-action" id="filter_groups_apply" data-jigconfig="'color': 'ui-ncbibutton-blue'">Show</button></div></div></ul><input name="EntrezSystem2.PEntrez.PMC.Facets.FacetsUrlFrag" sid="1" type="hidden" value="filters=" /><input name="EntrezSystem2.PEntrez.PMC.Facets.FacetSubmitted" sid="1" type="hidden" value="false" /><input name="EntrezSystem2.PEntrez.PMC.Facets.BMFacets" sid="1" type="hidden" value="" /></div>
|
||
</div>
|
||
<div id="maincontent" class="col seven_col">
|
||
<div class="content">
|
||
<div class="results_settings"><h4 class="left display_settings content_header jig-ncbipopper" id="display_set" data-jigconfig="triggerPosition : 'bottom center',destPosition : 'top center',destSelector : '#display_settings_menu', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : true, multipleHandlesSelector:'#display_set ~ ul.display_settings a', groupName: 'entrez_pg'"><a href="#" class="tgt_dark">Display Settings:</a></h4><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display" sid="2" href="#" sourceContent="display_settings_menu" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display">Summary,</a></li><li><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display" sid="3" href="#" sourceContent="display_settings_menu" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display">20 per page,</a></li><li><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display" sid="4" href="#" sourceContent="display_settings_menu" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display">Sorted by Default order</a></li></ul><div id="display_settings_menu" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation" sid="1" value="DocSum" format="" id="DocSum" checked="true" /><label for="DocSum">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation" sid="2" value="DocSum" format="text" id="DocSumtext" /><label for="DocSumtext">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation" sid="3" value="MEDLINE" format="text" id="MEDLINEtext" /><label for="MEDLINEtext">MEDLINE</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation" sid="4" value="uilist" format="text" id="uilisttext" /><label for="uilisttext">PMCID List</label></li></ul></fieldset><fieldset class="items"><legend>Items per page</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize" sid="1" value="5" id="ps5" /><label for="ps5">5</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize" sid="2" value="10" id="ps10" /><label for="ps10">10</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize" sid="3" value="20" id="ps20" checked="true" /><label for="ps20">20</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize" sid="4" value="50" id="ps50" /><label for="ps50">50</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize" sid="5" value="100" id="ps100" /><label for="ps100">100</label></li></ul></fieldset><fieldset class="sort"><legend>Sort by</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort" sid="1" value="none" id="none" checked="true" /><label for="none">Default order</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort" sid="2" value="PubDate" id="PubDate" /><label for="PubDate">Pub Date</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort" sid="3" value="Journal" id="Journal" /><label for="Journal">Journal</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort" sid="4" value="PmcLiveDate" id="PmcLiveDate" /><label for="PmcLiveDate">PMC Live Date</label></li></ul></fieldset><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SetDisplay" sid="1" class="button_apply ncbipopper-close-button">Apply</button></div><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto" data-jigconfig="triggerPosition:'bottom center', destPosition : 'top center',destSelector : '#send_to_menu', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu" class="tgt_dark">Send to:</a><script type="text/javascript">
|
||
jQuery(document).ready( function () {
|
||
jQuery("#send_to_menu input[type='radio']").click( function () {
|
||
var selectedValue = jQuery(this).val().toLowerCase();
|
||
var selectedDiv = jQuery("#send_to_menu div." + selectedValue);
|
||
|
||
if(selectedDiv.is(":hidden")){
|
||
jQuery("#send_to_menu div.submenu:visible").slideUp();
|
||
selectedDiv.slideDown();
|
||
}
|
||
});
|
||
|
||
});
|
||
|
||
jQuery("#sendto").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu input[type='radio']:checked").attr("checked",false);
|
||
});
|
||
|
||
</script></h4><div id="send_to_menu" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="1" value="File" id="dest_File" /><label for="dest_File">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="2" value="AddToClipboard" id="dest_AddToClipboard" /><label for="dest_AddToClipboard">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="3" value="Mail" id="dest_Mail" /><label for="dest_Mail">E-mail</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="4" value="AddToCollections" id="dest_AddToCollections" /><label for="dest_AddToCollections">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File" style="display: none;"><p id="submenu_File_hint" class="hidden"></p><ul><li><label for="file_format">Format</label><select id="file_format" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FFormat" sid="1"><option value="DocSum" format="text" selected="selected">Summary (text)</option><option value="MEDLINE" format="text">MEDLINE</option><option value="XML" format="text">XML</option><option value="uilist" format="text">PMCID List</option></select></li><li><label for="file_sort">Sort by</label><select id="file_sort" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FSort" sid="1"><option value="" selected="selected">Default order</option><option value="PubDate">Pub Date</option><option value="Journal">Journal</option><option value="PmcLiveDate">PMC Live Date</option></select></li></ul><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="1" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu mail" id="submenu_Mail" style="display: none;"><p id="email_alert" class="hidden"></p><ul><li id="email_desc">Search: "Expert Opin Orphan Drugs"[jour] </li><li><label for="email_format">Format</label><select id="email_format" name="email_format"><option value="DocSum" selected="selected">Summary</option><option value="DocSum" format="text">Summary (text)</option><option value="MEDLINE" format="text">MEDLINE</option><option value="uilist" format="text">PMCID List</option></select></li><li id="email_sort_option"><label for="email_sort">Sort by</label><select id="email_sort" name="email_sort"><option value="" selected="selected">Default order</option><option value="PubDate">Pub Date</option><option value="Journal">Journal</option><option value="PmcLiveDate">PMC Live Date</option></select></li><li id="email_count_option"><label for="email_count">Number to send</label><select id="email_count" name="email_count"><option value="5">5</option><option value="10">10</option><option value="20" selected="selected">20</option><option value="50">50</option><option value="100">100</option></select></li><li id="email_start_option"><label for="email_start">Start with item</label><input id="email_start" name="email_start" type="text" size="4" value="1" /></li><li><label for="email_address">E-mail</label><input id="email_address" value="" name="email_address" /></li></ul><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="2" class="button_apply email" type="submit" cmd="Mail" qk="90019">E-mail</button><div><a href="/corehtml/query/MyNCBI/exquery/spam_note.html" onclick="window.open('/corehtml/query/MyNCBI/exquery/spam_note.html','','resizable=yes,scrollbars=yes,toolbar=no,location=no,directories=no,status=no,menubar=no,copyhistory=no,alwaysRaised=yes,depend=yes,top=50,left=200,width=550,height=430');return false;">"SPAM" filtering software notice</a></div></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard" style="display: none;"><p id="submenu_AddToClipboard_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="3" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections" style="display: none;"><p id="submenu_AddToCollections_hint" class="hidden"></p><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="4" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div><div><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FileFormat" sid="1" type="hidden" value="docsum" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastPresentation" sid="1" type="hidden" value="docsum" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Presentation" sid="1" type="hidden" value="docsum" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.PageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastPageSize" sid="1" type="hidden" value="20" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Sort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FileSort" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Format" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.LastFormat" sid="1" type="hidden" value="" /></div></div>
|
||
<div>
|
||
|
||
|
||
|
||
</div>
|
||
<div class="title_and_pager">
|
||
<div><div class="pmc-search-experiment ncbi-undecorated-link">
|
||
You searched <b>8+ million full text articles</b><p></p><a class="usa-external_link" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22expert%20opin%20orphan%20drugs%22%5Bjour%5D" data-ga-category="search experiment" data-ga-action="click docsum link" data-ga-label="try_this_search_in_abstracts" target="_blank">
|
||
Try this search in <b>34+ million citations and abstracts</b></a></div><h2>PMC Full-Text Search Results</h2><h3 class="result_count left">Items: 1 to 20 of 54</h3><span id="result_sel" class="nowrap"></span><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_ResultsSearchController.ResultCount" sid="1" type="hidden" id="resultcount" value="54" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_ResultsSearchController.RunLastQuery" sid="1" type="hidden" /></div>
|
||
<div class="pagination"><span title="Inactive first page of results" class="inactive page_link"><< First</span><span title="Inactive previous page of results" class="inactive page_link prev">< Prev</span><h3 class="page"><label for="pageno">Page </label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.cPage" id="pageno" type="text" class="num" sid="1" value="1" last="3" /> of 3</h3><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page" title="Next page of results" class="active page_link next" href="#" sid="3" page="2" accesskey="k" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page">Next ></a><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page" title="Last page of results" class="active page_link" href="#" sid="4" page="3" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page">Last >></a><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.CurrPage" sid="1" type="hidden" value="1" /></div>
|
||
</div>
|
||
<div id="messagearea" class="empty">
|
||
|
||
|
||
|
||
|
||
</div>
|
||
<div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox9087212" class="ui-helper-hidden-accessible">Select item 9087212</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="1" type="checkbox" id="UidCheckBox9087212" value="9087212" /><span>1.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=1&ncbi_uid=9087212&link_uid=9087212&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9087212/" class="view">Drugs and biologics receiving FDA orphan drug designation: an analysis of the most frequently designated products and their repositioning strategies</a></div><div class="supp"><div class="desc">Kathleen L. Miller, Selma Kraft, Abraham Ipe, Lewis Fermaglich</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2022 May 10.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2022 Mar 1; 9(11-12): 265–272. <span class="doi"><span>doi: </span>10.1080/21678707.2021.2047021</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC9087212</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=1&ncbi_uid=9087212&link_uid=9087212&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9087212/">Article</a><a ref="ordinalpos=1&ncbi_uid=9087212&link_uid=9087212&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC9087212/pdf/nihms-1785000.pdf">PDF–542K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox7676758" class="ui-helper-hidden-accessible">Select item 7676758</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="2" type="checkbox" id="UidCheckBox7676758" value="7676758" /><span>2.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=2&ncbi_uid=7676758&link_uid=7676758&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7676758/" class="view">The future of gene-targeted therapy for hereditary tyrosinemia type 1 as a lead indication among the inborn errors of metabolism</a></div><div class="supp"><div class="desc">Whitney S. Thompson, Gourish Mondal, Caitlin J. Vanlith, Robert A. Kaiser, Joseph B. Lillegard</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2020 Nov 19.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2020; 8(7): 245–256. <span class="">Published online 2020 Jul 21. </span><span class="doi"><span>doi: </span>10.1080/21678707.2020.1791082</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC7676758</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=2&ncbi_uid=7676758&link_uid=7676758&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7676758/">Article</a><a ref="ordinalpos=2&ncbi_uid=7676758&link_uid=7676758&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7676758/pdf/nihms-1625187.pdf">PDF–592K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox7104334" class="ui-helper-hidden-accessible">Select item 7104334</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="3" type="checkbox" id="UidCheckBox7104334" value="7104334" /><span>3.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=3&ncbi_uid=7104334&link_uid=7104334&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7104334/" class="view">Monitoring progression of retinitis pigmentosa: current recommendations and recent advances</a></div><div class="supp"><div class="desc">Moreno Menghini, Jasmina Cehajic-Kapetanovic, Robert E MacLaren</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2020 Mar 30.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2020; 8(2-3): 67–78. <span class="">Published online 2020 Mar 2. </span><span class="doi"><span>doi: </span>10.1080/21678707.2020.1735352</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC7104334</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=3&ncbi_uid=7104334&link_uid=7104334&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7104334/">Article</a><a ref="ordinalpos=3&ncbi_uid=7104334&link_uid=7104334&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7104334/pdf/EMS85947.pdf">PDF–1.6M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox7755158" class="ui-helper-hidden-accessible">Select item 7755158</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="4" type="checkbox" id="UidCheckBox7755158" value="7755158" /><span>4.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=4&ncbi_uid=7755158&link_uid=7755158&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7755158/" class="view">Advances in the Treatment of Neuronal Ceroid Lipofuscinosis</a></div><div class="supp"><div class="desc">Jonathan B. Rosenberg, Alvin Chen, Stephen M. Kaminsky, Ronald G. Crystal, Dolan Sondhi</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2020 Dec 22.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2019; 7(11): 473–500. <span class="">Published online 2019 Nov 27. </span><span class="doi"><span>doi: </span>10.1080/21678707.2019.1684258</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC7755158</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=4&ncbi_uid=7755158&link_uid=7755158&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7755158/">Article</a><a ref="ordinalpos=4&ncbi_uid=7755158&link_uid=7755158&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7755158/pdf/nihms-1653596.pdf">PDF–535K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox7577425" class="ui-helper-hidden-accessible">Select item 7577425</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="5" type="checkbox" id="UidCheckBox7577425" value="7577425" /><span>5.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=5&ncbi_uid=7577425&link_uid=7577425&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7577425/" class="view">Advances in potential treatment options for myeloproliferative neoplasm associated myelofibrosis</a></div><div class="supp"><div class="desc">Prithviraj Bose</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2020 Oct 21.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2019; 7(10): 415–425. <span class="">Published online 2019 Sep 24. </span><span class="doi"><span>doi: </span>10.1080/21678707.2019.1664900</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC7577425</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=5&ncbi_uid=7577425&link_uid=7577425&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7577425/">Article</a><a ref="ordinalpos=5&ncbi_uid=7577425&link_uid=7577425&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7577425/pdf/nihms-1541954.pdf">PDF–360K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox6375487" class="ui-helper-hidden-accessible">Select item 6375487</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="6" type="checkbox" id="UidCheckBox6375487" value="6375487" /><span>6.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=6&ncbi_uid=6375487&link_uid=6375487&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6375487/" class="view">CAR-T immunotherapy: how will it change treatment for acute lymphoblastic leukemia and beyond?</a></div><div class="supp"><div class="desc">Christian M. Capitini</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2019 Oct 8.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2018; 6(10): 563–566. <span class="">Published online 2018 Oct 8. </span><span class="doi"><span>doi: </span>10.1080/21678707.2018.1529562</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC6375487</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=6&ncbi_uid=6375487&link_uid=6375487&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6375487/">Article</a><a ref="ordinalpos=6&ncbi_uid=6375487&link_uid=6375487&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6375487/pdf/nihms-1514583.pdf">PDF–53K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox6296476" class="ui-helper-hidden-accessible">Select item 6296476</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="7" type="checkbox" id="UidCheckBox6296476" value="6296476" /><span>7.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=7&ncbi_uid=6296476&link_uid=6296476&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6296476/" class="view">Updates and challenges on treatment with BRAF/MEK-inhibitors in melanoma</a></div><div class="supp"><div class="desc">Zeynep Eroglu, Alpaslan Ozgun</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2019 Aug 28.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2018; 6(9): 545–551. <span class="">Published online 2018 Aug 28. </span><span class="doi"><span>doi: </span>10.1080/21678707.2018.1512402</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC6296476</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=7&ncbi_uid=6296476&link_uid=6296476&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6296476/">Article</a><a ref="ordinalpos=7&ncbi_uid=6296476&link_uid=6296476&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6296476/pdf/nihms-1514581.pdf">PDF–67K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox6059358" class="ui-helper-hidden-accessible">Select item 6059358</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="8" type="checkbox" id="UidCheckBox6059358" value="6059358" /><span>8.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=8&ncbi_uid=6059358&link_uid=6059358&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6059358/" class="view">Gene therapy for the treatment of X-linked retinitis pigmentosa</a></div><div class="supp"><div class="desc">Cristina Martinez-Fernandez De La Camara, Anika Nanda, Anna Paola Salvetti, M. Dominik Fischer, Robert E. MacLaren</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2018 Jul 25.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2018 Feb 27; 6(3): 167–177. <span class="">Published online 2018 Feb 27. </span><span class="doi"><span>doi: </span>10.1080/21678707.2018.1444476</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC6059358</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=8&ncbi_uid=6059358&link_uid=6059358&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6059358/">Article</a><a ref="ordinalpos=8&ncbi_uid=6059358&link_uid=6059358&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6059358/pdf/emss-78602.pdf">PDF–1.2M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox5697787" class="ui-helper-hidden-accessible">Select item 5697787</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="9" type="checkbox" id="UidCheckBox5697787" value="5697787" /><span>9.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=9&ncbi_uid=5697787&link_uid=5697787&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5697787/" class="view">Hard targets for a second skeleton: therapeutic horizons for fibrodysplasia ossificans progressiva (FOP)</a></div><div class="supp"><div class="desc">Frederick S. Kaplan, Robert J. Pignolo, Mona M. Al Mukaddam, Eileen M. Shore</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2018 Mar 17.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2017; 5(4): 291–294. <span class="">Published online 2017 Mar 17. </span><span class="doi"><span>doi: </span>10.1080/21678707.2017.1304211</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC5697787</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=9&ncbi_uid=5697787&link_uid=5697787&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5697787/">Article</a><a ref="ordinalpos=9&ncbi_uid=5697787&link_uid=5697787&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5697787/pdf/nihms889750.pdf">PDF–386K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox5693349" class="ui-helper-hidden-accessible">Select item 5693349</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="10" type="checkbox" id="UidCheckBox5693349" value="5693349" /><span>10.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=10&ncbi_uid=5693349&link_uid=5693349&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5693349/" class="view">Presentation and Treatments for Mucopolysaccharidosis Type II (MPS II; Hunter Syndrome)</a></div><div class="supp"><div class="desc">Molly Stapleton, Francyne Kubaski, Robert W. Mason, Hiromasa Yabe, Yasuyuki Suzuki, Kenji E. Orii, Tadao Orii, Shunji Tomatsu</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2018 Mar 8.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2017; 5(4): 295–307. <span class="">Published online 2017 Mar 8. </span><span class="doi"><span>doi: </span>10.1080/21678707.2017.1296761</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC5693349</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=10&ncbi_uid=5693349&link_uid=5693349&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5693349/">Article</a><a ref="ordinalpos=10&ncbi_uid=5693349&link_uid=5693349&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5693349/pdf/nihms889744.pdf">PDF–803K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox5461780" class="ui-helper-hidden-accessible">Select item 5461780</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="11" type="checkbox" id="UidCheckBox5461780" value="5461780" /><span>11.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=11&ncbi_uid=5461780&link_uid=5461780&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5461780/" class="view">Galactosialidosis: historic aspects and overview of investigated and emerging treatment options</a></div><div class="supp"><div class="desc">Ida Annunziata, Alessandra d’Azzo</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2018 Jan 1.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2017; 5(2): 131–141. <span class="">Published online 2016 Dec 14. </span><span class="doi"><span>doi: </span>10.1080/21678707.2016.1266933</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC5461780</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=11&ncbi_uid=5461780&link_uid=5461780&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5461780/">Article</a><a ref="ordinalpos=11&ncbi_uid=5461780&link_uid=5461780&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5461780/pdf/nihms850543.pdf">PDF–859K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox5472383" class="ui-helper-hidden-accessible">Select item 5472383</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="12" type="checkbox" id="UidCheckBox5472383" value="5472383" /><span>12.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=12&ncbi_uid=5472383&link_uid=5472383&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5472383/" class="view">Tissue Chips to aid drug development and modeling for rare diseases</a></div><div class="supp"><div class="desc">Lucie A. Low, Danilo A. Tagle</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2017 Oct 19.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2016; 4(11): 1113–1121. <span class="">Published online 2016 Oct 19. </span><span class="doi"><span>doi: </span>10.1080/21678707.2016.1244479</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC5472383</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=12&ncbi_uid=5472383&link_uid=5472383&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5472383/">Article</a><a ref="ordinalpos=12&ncbi_uid=5472383&link_uid=5472383&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5472383/pdf/nihms-832287.pdf">PDF–483K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox5487007" class="ui-helper-hidden-accessible">Select item 5487007</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="13" type="checkbox" id="UidCheckBox5487007" value="5487007" /><span>13.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=13&ncbi_uid=5487007&link_uid=5487007&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5487007/" class="view">Pharmacological therapeutics targeting the secondary defects and downstream pathology of Duchenne muscular dystrophy</a></div><div class="supp"><div class="desc">Dr. Janelle M. Spinazzola, Dr. Louis M. Kunkel</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2017 Oct 18.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2016; 4(11): 1179–1194. <span class="">Published online 2016 Oct 18. </span><span class="doi"><span>doi: </span>10.1080/21678707.2016.1240613</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC5487007</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=13&ncbi_uid=5487007&link_uid=5487007&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5487007/">Article</a><a ref="ordinalpos=13&ncbi_uid=5487007&link_uid=5487007&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5487007/pdf/nihms832286.pdf">PDF–623K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox5312776" class="ui-helper-hidden-accessible">Select item 5312776</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="14" type="checkbox" id="UidCheckBox5312776" value="5312776" /><span>14.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=14&ncbi_uid=5312776&link_uid=5312776&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5312776/" class="view">Current therapies for Morquio A syndrome and their clinical outcomes</a></div><div class="supp"><div class="desc">Kazuki Sawamoto, Yasuyuki Suzuki, William G. Mackenzie, Mary C. Theroux, Christian Pizarro, Hiromasa Yabe, Kenji E. Orii, Robert W. Mason, Tadao Orii, Shunji Tomatsu</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2017 Feb 16.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2016; 4(9): 941–951. <span class="">Published online 2016 Jul 28. </span><span class="doi"><span>doi: </span>10.1080/21678707.2016.1214572</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC5312776</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=14&ncbi_uid=5312776&link_uid=5312776&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5312776/">Article</a><a ref="ordinalpos=14&ncbi_uid=5312776&link_uid=5312776&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5312776/pdf/nihms814147.pdf">PDF–829K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox5010088" class="ui-helper-hidden-accessible">Select item 5010088</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="15" type="checkbox" id="UidCheckBox5010088" value="5010088" /><span>15.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=15&ncbi_uid=5010088&link_uid=5010088&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5010088/" class="view">Pembrolizumab for the treatment of advanced melanoma</a></div><div class="supp"><div class="desc">Michael C Burns, Aidan O’Donnell, Igor Puzanov</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2017 Jun 7.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2016; 4(8): 867–873. <span class="">Published online 2016 Jun 7. </span><span class="doi"><span>doi: </span>10.1080/21678707.2016.1191348</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC5010088</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=15&ncbi_uid=5010088&link_uid=5010088&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5010088/">Article</a><a ref="ordinalpos=15&ncbi_uid=5010088&link_uid=5010088&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5010088/pdf/nihms806847.pdf">PDF–378K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox4651452" class="ui-helper-hidden-accessible">Select item 4651452</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="16" type="checkbox" id="UidCheckBox4651452" value="4651452" /><span>16.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=16&ncbi_uid=4651452&link_uid=4651452&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4651452/" class="view">Gene Therapy for Duchenne muscular dystrophy</a></div><div class="supp"><div class="desc">Julian Ramos, Jeffrey S Chamberlain</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2015 Nov 18.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2015; 3(11): 1255–1266. <span class="">Published online 2015 Oct 6. </span><span class="doi"><span>doi: </span>10.1517/21678707.2015.1088780</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC4651452</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=16&ncbi_uid=4651452&link_uid=4651452&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4651452/">Article</a><a ref="ordinalpos=16&ncbi_uid=4651452&link_uid=4651452&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4651452/pdf/nihms731340.pdf">PDF–607K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox4643203" class="ui-helper-hidden-accessible">Select item 4643203</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="17" type="checkbox" id="UidCheckBox4643203" value="4643203" /><span>17.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=17&ncbi_uid=4643203&link_uid=4643203&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4643203/" class="view">New therapeutic targets in rare genetic skeletal diseases</a></div><div class="supp"><div class="desc">Michael D Briggs, Peter A Bell, Michael J Wright, Katarzyna A Pirog</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="citation-publication-date">2015 Oct 3; </span>3(10): 1137–1154. <span class="">Published online 2015 Sep 24. </span><span class="doi"><span>doi: </span>10.1517/21678707.2015.1083853</span></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC4643203</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=17&ncbi_uid=4643203&link_uid=4643203&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4643203/">Article</a><a ref="ordinalpos=17&ncbi_uid=4643203&link_uid=4643203&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4643203/pdf/ieod-3-1137.pdf">PDF–660K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox4993532" class="ui-helper-hidden-accessible">Select item 4993532</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="18" type="checkbox" id="UidCheckBox4993532" value="4993532" /><span>18.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=18&ncbi_uid=4993532&link_uid=4993532&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4993532/" class="view">Novel Therapeutic Strategies for the Management of Ventricular Arrhythmias Associated with the Brugada Syndrome</a></div><div class="supp"><div class="desc">Bence Patocskai, Charles Antzelevitch</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2016 Aug 22.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2015; 3(6): 633–651. <span class="">Published online 2015 May 13. </span><span class="doi"><span>doi: </span>10.1517/21678707.2015.1037280</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC4993532</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=18&ncbi_uid=4993532&link_uid=4993532&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4993532/">Article</a><a ref="ordinalpos=18&ncbi_uid=4993532&link_uid=4993532&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4993532/pdf/nihms774947.pdf">PDF–4.1M</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox6684277" class="ui-helper-hidden-accessible">Select item 6684277</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="19" type="checkbox" id="UidCheckBox6684277" value="6684277" /><span>19.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=19&ncbi_uid=6684277&link_uid=6684277&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6684277/" class="view">Bosutinib for the Treatment of Philadelphia Chromosome-Positive Leukemias</a></div><div class="supp"><div class="desc">Cristina Varallo-Rodriguez, Craig W. Freyer, Jr, Evelena P. Ontiveros, Elizabeth A. Griffiths, Eunice S Wang, Meir Wetzler</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2019 Aug 6.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2015; 3(5): 599–608. <span class="">Published online 2015 Apr 16. </span><span class="doi"><span>doi: </span>10.1517/21678707.2015.1036027</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC6684277</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=19&ncbi_uid=6684277&link_uid=6684277&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6684277/">Article</a><a ref="ordinalpos=19&ncbi_uid=6684277&link_uid=6684277&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6684277/pdf/nihms-742026.pdf">PDF–107K</a></div></div></div></div><div class="rprt"><div class="rprtnum"><label for="UidCheckBox4777310" class="ui-helper-hidden-accessible">Select item 4777310</label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_RVDocSum.uid" sid="20" type="checkbox" id="UidCheckBox4777310" value="4777310" /><span>20.</span></div><div class="rslt"><div class="title"><a ref="ordinalpos=20&ncbi_uid=4777310&link_uid=4777310&linksrc=docsum_title" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4777310/" class="view">Pathogenesis, Emerging therapeutic targets and Treatment in Sialidosis</a></div><div class="supp"><div class="desc">Alessandra d’Azzo, Eda Machado, Ida Annunziata</div><div class="details"><b>Expert Opin Orphan Drugs</b>. <span class="ms-submitted-date">Author manuscript; available in PMC 2016 Mar 3.</span><div>Published in final edited form as: <b>Expert Opin Orphan Drugs</b>. 2015; 3(5): 491–504. <span class="">Published online 2015 Apr 13. </span><span class="doi"><span>doi: </span>10.1517/21678707.2015.1025746</span></div></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMCID: </dt><dd>PMC4777310</dd></dl></div></div><div class="aux"><div class="links"><a ref="ordinalpos=20&ncbi_uid=4777310&link_uid=4777310&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4777310/">Article</a><a ref="ordinalpos=20&ncbi_uid=4777310&link_uid=4777310&linksrc=docsum_title" class="view" href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4777310/pdf/nihms737311.pdf">PDF–1022K</a></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class="title_and_pager bottom">
|
||
<div class="pagination"><span title="Inactive first page of results" class="inactive page_link"><< First</span><span title="Inactive previous page of results" class="inactive page_link prev">< Prev</span><h3 class="page"><label for="pageno2">Page </label><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.cPage" id="pageno2" type="text" class="num" sid="6" value="1" last="3" /> of 3</h3><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page" title="Next page of results" class="active page_link next" href="#" sid="8" page="2" accesskey="k" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page">Next ></a><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page" title="Last page of results" class="active page_link" href="#" sid="9" page="3" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Entrez_Pager.Page">Last >></a></div>
|
||
</div>
|
||
<div class="results_settings bottom"><h4 class="left display_settings content_header jig-ncbipopper" id="display_set2" data-jigconfig="triggerPosition : 'top center',destPosition : 'bottom center',destSelector : '#display_settings_menu2', hasArrow : false,openEvent : 'click',closeEvent : 'click',isTriggerElementCloseClick: false,addCloseButton : true, multipleHandlesSelector:'#display_set2 ~ ul.display_settings a', groupName: 'entrez_pg'"><a href="#" class="tgt_dark">Display Settings:</a></h4><ul class="inline_list left display_settings"><li><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display" sid="12" href="#" sourceContent="display_settings_menu2" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display">Summary,</a></li><li><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display" sid="13" href="#" sourceContent="display_settings_menu2" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display">20 per page,</a></li><li><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display" sid="14" href="#" sourceContent="display_settings_menu2" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.Display">Sorted by Default order</a></li></ul><div id="display_settings_menu2" class="disp_settings tabPopper"><fieldset class="format"><legend>Format</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation2" sid="21" value="DocSum" format="" id="DocSum2" checked="true" /><label for="DocSum2">Summary</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation2" sid="22" value="DocSum" format="text" id="DocSumtext2" /><label for="DocSumtext2">Summary (text)</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation2" sid="23" value="MEDLINE" format="text" id="MEDLINEtext2" /><label for="MEDLINEtext2">MEDLINE</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPresentation2" sid="24" value="uilist" format="text" id="uilisttext2" /><label for="uilisttext2">PMCID List</label></li></ul></fieldset><fieldset class="items"><legend>Items per page</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize2" sid="11" value="5" id="ps52" /><label for="ps52">5</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize2" sid="12" value="10" id="ps102" /><label for="ps102">10</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize2" sid="13" value="20" id="ps202" checked="true" /><label for="ps202">20</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize2" sid="14" value="50" id="ps502" /><label for="ps502">50</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sPageSize2" sid="15" value="100" id="ps1002" /><label for="ps1002">100</label></li></ul></fieldset><fieldset class="sort"><legend>Sort by</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort2" sid="11" value="none" id="none2" checked="true" /><label for="none2">Default order</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort2" sid="12" value="PubDate" id="PubDate2" /><label for="PubDate2">Pub Date</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort2" sid="13" value="Journal" id="Journal2" /><label for="Journal2">Journal</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.sSort2" sid="14" value="PmcLiveDate" id="PmcLiveDate2" /><label for="PmcLiveDate2">PMC Live Date</label></li></ul></fieldset><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SetDisplay" sid="2" class="button_apply ncbipopper-close-button">Apply</button></div><h4 class="content_header send_to align_right jig-ncbipopper" id="sendto2" data-jigconfig="triggerPosition:'top center', destPosition : 'bottom center',destSelector : '#send_to_menu2', hasArrow : false, openEvent : 'click',closeEvent : 'click', isTriggerElementCloseClick: false, addCloseButton:true, groupName: 'entrez_pg', adjustFit:'none'"><a href="#" sourceContent="send_to_menu2" class="tgt_dark">Send to:</a><script type="text/javascript">
|
||
jQuery(document).ready( function () {
|
||
jQuery("#send_to_menu2 input[type='radio']").click( function () {
|
||
var selectedValue = jQuery(this).val().toLowerCase();
|
||
var selectedDiv = jQuery("#send_to_menu2 div." + selectedValue);
|
||
|
||
if(selectedDiv.is(":hidden")){
|
||
jQuery("#send_to_menu2 div.submenu:visible").slideUp();
|
||
selectedDiv.slideDown();
|
||
}
|
||
});
|
||
|
||
});
|
||
|
||
jQuery("#sendto2").bind("ncbipopperclose", function(){
|
||
jQuery("#send_to_menu2 div.submenu:visible").css("display","none");
|
||
jQuery("#send_to_menu2 input[type='radio']:checked").attr("checked",false);
|
||
});
|
||
|
||
</script></h4><div id="send_to_menu2" class="tabPopper send_to"><fieldset><legend>Choose Destination</legend><ul class="column_list"><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="11" value="File" id="dest_File2" /><label for="dest_File2">File</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="12" value="AddToClipboard" id="dest_AddToClipboard2" /><label for="dest_AddToClipboard2">Clipboard</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="13" value="Mail" id="dest_Mail2" /><label for="dest_Mail2">E-mail</label></li><li><input type="radio" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendTo" sid="14" value="AddToCollections" id="dest_AddToCollections2" /><label for="dest_AddToCollections2">Collections</label></li></ul></fieldset><div class="submenu file" id="submenu_File2" style="display: none;"><p id="submenu_File_hint2" class="hidden"></p><ul><li><label for="file_format2">Format</label><select id="file_format2" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FFormat2" sid="101"><option value="DocSum" format="text" selected="selected">Summary (text)</option><option value="MEDLINE" format="text">MEDLINE</option><option value="XML" format="text">XML</option><option value="uilist" format="text">PMCID List</option></select></li><li><label for="file_sort2">Sort by</label><select id="file_sort2" name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.FSort2" sid="51"><option value="" selected="selected">Default order</option><option value="PubDate">Pub Date</option><option value="Journal">Journal</option><option value="PmcLiveDate">PMC Live Date</option></select></li></ul><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="11" class="button_apply file ncbipopper-close-button" type="submit" cmd="File">Create File</button></div><div class="submenu mail" id="submenu_Mail2" style="display: none;"><p id="email_alert2" class="hidden"></p><ul><li id="email_desc2">Search: "Expert Opin Orphan Drugs"[jour] </li><li><label for="email_format2">Format</label><select id="email_format2" name="email_format2"><option value="DocSum" selected="selected">Summary</option><option value="DocSum" format="text">Summary (text)</option><option value="MEDLINE" format="text">MEDLINE</option><option value="uilist" format="text">PMCID List</option></select></li><li id="email_sort_option2"><label for="email_sort2">Sort by</label><select id="email_sort2" name="email_sort2"><option value="" selected="selected">Default order</option><option value="PubDate">Pub Date</option><option value="Journal">Journal</option><option value="PmcLiveDate">PMC Live Date</option></select></li><li id="email_count_option2"><label for="email_count2">Number to send</label><select id="email_count2" name="email_count2"><option value="5">5</option><option value="10">10</option><option value="20" selected="selected">20</option><option value="50">50</option><option value="100">100</option></select></li><li id="email_start_option2"><label for="email_start2">Start with item</label><input id="email_start2" name="email_start2" type="text" size="4" value="1" /></li><li><label for="email_address2">E-mail</label><input id="email_address2" value="" name="email_address2" /></li></ul><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="12" class="button_apply email" type="submit" cmd="Mail" qk="90019">E-mail</button><div><a href="/corehtml/query/MyNCBI/exquery/spam_note.html" onclick="window.open('/corehtml/query/MyNCBI/exquery/spam_note.html','','resizable=yes,scrollbars=yes,toolbar=no,location=no,directories=no,status=no,menubar=no,copyhistory=no,alwaysRaised=yes,depend=yes,top=50,left=200,width=550,height=430');return false;">"SPAM" filtering software notice</a></div></div><div class="submenu addtoclipboard" id="submenu_AddToClipboard2" style="display: none;"><p id="submenu_AddToClipboard_hint2" class="hidden"></p><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="13" class="button_apply clipboard ncbipopper-close-button" type="submit" cmd="AddToClipboard">Add to Clipboard</button></div><div class="submenu addtocollections" id="submenu_AddToCollections2" style="display: none;"><p id="submenu_AddToCollections_hint2" class="hidden"></p><button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_DisplayBar.SendToSubmit" sid="14" class="button_apply collections ncbipopper-close-button" type="submit" cmd="AddToCollections">Add to Collections</button></div></div></div>
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
<div class="filters app_msg"><p><strong>Filter your results:</strong></p><ul class="portlet_list"><li class="filter_selected"><a title="Total Results">All (54) </a></li><li><a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab.Filter" filter="nih grants" sid="2" href="#" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab.Filter">NIH grants (49)</a></li><li><a class="empty_link" title="Embargoed Articles">Embargoed (0)</a></li></ul><ul class="inline_list app_msg_controls"><li><a href="/sites/myncbi/pmc/filters">Manage Filters</a></li></ul><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab.CurrFilter" sid="1" type="hidden" value="all" /><input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_FilterTab.LastFilter" sid="1" type="hidden" value="all" /></div>
|
||
|
||
<div class="hidden"></div>
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Find related data</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="RelatedDataLinks" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul class="related">
|
||
<li>
|
||
<label for="rdDatabase">Database: </label>
|
||
<select name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.rdDatabase" sid="1" id="rdDatabase">
|
||
<option value="rddbto">Select</option>
|
||
<option value="bioproject">BioProject</option>
|
||
<option value="books">Books</option>
|
||
<option value="clinvar">ClinVar</option>
|
||
<option value="cdd">Conserved Domains</option>
|
||
<option value="gap">dbGaP</option>
|
||
<option value="gene">Gene</option>
|
||
<option value="gds">GEO DataSets</option>
|
||
<option value="geoprofiles">GEO Profiles</option>
|
||
<option value="medgen">MedGen</option>
|
||
<option value="nuccore">Nucleotide</option>
|
||
<option value="omim">OMIM</option>
|
||
<option value="protein">Protein</option>
|
||
<option value="pcassay">PubChem BioAssay</option>
|
||
<option value="pccompound">PubChem Compound</option>
|
||
<option value="pcsubstance">PubChem Substance</option>
|
||
<option value="pubmed">PubMed</option>
|
||
<option value="snp">SNP</option>
|
||
<option value="sra">SRA</option>
|
||
<option value="structure">Structure</option>
|
||
<option value="taxonomy">Taxonomy</option>
|
||
</select>
|
||
</li>
|
||
<li>
|
||
<div id="rdOption" style="display: none;">
|
||
<label for="rdLinkOption">Option: </label>
|
||
<select name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.rdLinkOption" sid="1" id="rdLinkOption"></select>
|
||
</div>
|
||
</li>
|
||
</ul>
|
||
<p id="rdDescr"></p>
|
||
<button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.rdFind" sid="1" id="rdFind" disabled="disabled" class="jig-ncbibutton">Find items</button>
|
||
<input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Pmc_MultiItemSupl.Pmc_RelatedDataLinks.DbName" sid="1" type="hidden" id="DbName" value="pmc" />
|
||
<input type="hidden" id="rdqk" value="90019" />
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Search details</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Discovery_SearchDetails" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<textarea name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails.SearchDetailsTerm" sid="1" class="searchdetails_term" cols="30" rows="5" db="pmc">"Expert Opin Orphan Drugs"[jour]</textarea>
|
||
<div class="buttonwrap">
|
||
<button name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.Discovery_SearchDetails.SearchDetailsQuery" sid="1" class="jig-ncbibutton">Search</button>
|
||
</div>
|
||
<a class="seemore" href="/pmc/details?querykey=90019" ref="log$=details">
|
||
See more...
|
||
</a>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
|
||
<a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.ClearHistory" sid="1" realname="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.ClearHistory" cmd="ClearHT" href="?cmd=ClearHT&" onclick="return false;" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.ClearHistory">
|
||
Clear
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryToggle" sid="1" realname="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOn" cmd="HTOff" href="?cmd=HTOff&" onclick="return false;" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn Off
|
||
</a>
|
||
<a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryToggle" sid="2" realname="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryToggle" class="HTOff" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryToggle">
|
||
Turn On
|
||
</a>
|
||
</div>
|
||
<ul id="activity">
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67dc1b7a2f30673f7b5f4bad">"Expert Opin Orphan Drugs"[jour] <span class="number">(54)</span></a>
|
||
<div class="tertiary">PMC</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=2" href="/portal/utils/pageresolver.fcgi?recordid=67dc1b372f30673f7b5d9377">"Orthop Rev (Pavia)"[jour] <span class="number">(730)</span></a>
|
||
<div class="tertiary">PMC</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=3" href="/portal/utils/pageresolver.fcgi?recordid=67dc1aff67c23b31e01b6dfa">"Mol Pharm"[jour] <span class="number">(1587)</span></a>
|
||
<div class="tertiary">PMC</div>
|
||
</li>
|
||
<li class="ra_qry two_line">
|
||
<a class="htb" ref="log$=activity&linkpos=4" href="/portal/utils/pageresolver.fcgi?recordid=67dc1add84f3725e59850c33">"Diagnostics (Basel)"[jour] <span class="number">(14481)</span></a>
|
||
<div class="tertiary">PMC</div>
|
||
</li>
|
||
<li class="ra_rcd ralinkpopper two_line">
|
||
<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=5" href="/portal/utils/pageresolver.fcgi?recordid=67dc1abf67c23b31e019ddc4">Chicken mRNA for avidin</a>
|
||
<div class="ralinkpop offscreen_noflow">Chicken mRNA for avidin<div class="brieflinkpopdesc">gi|63071|emb|X05343.1|</div></div>
|
||
<div class="tertiary">Nucleotide</div>
|
||
</li>
|
||
</ul>
|
||
<p class="HTOn">Your browsing activity is empty.</p>
|
||
<p class="HTOff">Activity recording is turned off.</p>
|
||
<p id="turnOn" class="HTOff">
|
||
<a name="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryOn" sid="1" realname="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryOn" cmd="HTOn" href="?cmd=HTOn&" onclick="return false;" id="EntrezSystem2.PEntrez.PMC.Pmc_ResultsPanel.HistoryDisplay.HistoryOn">Turn recording back on</a>
|
||
</p>
|
||
<a class="seemore" href="/sites/myncbi/recentactivity">See more...</a>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
|
||
<div id="NCBIFooter_dynamic">
|
||
<div class="breadcrumbs">You are here:
|
||
<span id="breadcrumb_text"><a href="/guide/">NCBI</a> > <a href="https://www.ncbi.nlm.nih.gov/guide/literature/">Literature</a> > PubMed Central (PMC)</span></div>
|
||
<a id="help-desk-link" class="help_desk" href="https://support.ncbi.nlm.nih.gov/ics/support/KBList.asp?Time=2025-03-20T09:43:22-04:00&Snapshot=%2Fprojects%2FPMC%2FPMCEntrez@3.28&Host=portal106&ncbi_phid=CE8D05537DC158610000000000860078&ncbi_session=CE8BC1E97D9F05E1_0182SID&from=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2F&folderID=132&db=pmc&Ncbi_App=entrez&Page=docsum&style=classic&deptID=28049&report=docsum&querykey=90019&query=%22Expert%20Opin%20Orphan%20Drugs%22[jour];%20Page%20number:%201;%20Page%20size:%2020&term=%22Expert%20Opin%20Orphan%20Drugs%22[jour]" rel="noopener noreferrer" target="_blank">Support Center</a>
|
||
<noscript><img alt="" src="/stat?jsdisabled=true&ncbi_app=entrez&ncbi_db=pmc&ncbi_pdid=docsum&ncbi_phid=CE8D05537DC158610000000000860078" /></noscript>
|
||
</div>
|
||
|
||
<div xmlns="http://www.w3.org/1999/xhtml" class="footer" id="footer" xml:base="http://127.0.0.1/sites/static/header_footer/">
|
||
<section class="icon-section">
|
||
<div id="icon-section-header" class="icon-section_header">Follow NCBI</div>
|
||
<div class="grid-container container">
|
||
<div class="icon-section_container">
|
||
<a class="footer-icon" id="footer_twitter" href="https://twitter.com/ncbi" aria-label="Twitter">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="40" height="40" viewBox="0 0 40 40" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1008">
|
||
<path id="path1008" d="M6.06736 7L16.8778 20.8991L6.00001 32.2H10.2L18.6 23.1L25.668 32.2H34L22.8 17.5L31.9 7H28.4L20.7 15.4L14.401 7H6.06898H6.06736ZM9.66753 8.73423H12.9327L29.7327 30.4658H26.5697L9.66753 8.73423Z" fill="#5B616B"></path>
|
||
</g>
|
||
</svg>
|
||
</a>
|
||
<a class="footer-icon" id="footer_facebook" href="https://www.facebook.com/ncbi.nlm" aria-label="Facebook"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>Facebook</title>
|
||
<path class="cls-11" d="M210.5,115.12H171.74V97.82c0-8.14,5.39-10,9.19-10h27.14V52l-39.32-.12c-35.66,0-42.42,26.68-42.42,43.77v19.48H99.09v36.32h27.24v109h45.41v-109h35Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_linkedin" href="https://www.linkedin.com/company/ncbinlm" aria-label="LinkedIn"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<title>LinkedIn</title>
|
||
<path class="cls-11" d="M101.64,243.37H57.79v-114h43.85Zm-22-131.54h-.26c-13.25,0-21.82-10.36-21.82-21.76,0-11.65,8.84-21.15,22.33-21.15S101.7,78.72,102,90.38C102,101.77,93.4,111.83,79.63,111.83Zm100.93,52.61A17.54,17.54,0,0,0,163,182v61.39H119.18s.51-105.23,0-114H163v13a54.33,54.33,0,0,1,34.54-12.66c26,0,44.39,18.8,44.39,55.29v58.35H198.1V182A17.54,17.54,0,0,0,180.56,164.44Z">
|
||
</path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_github" href="https://github.com/ncbi" aria-label="GitHub"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 300 300">
|
||
<defs>
|
||
<style>
|
||
.cls-11,
|
||
.cls-12 {
|
||
fill: #737373;
|
||
}
|
||
|
||
.cls-11 {
|
||
fill-rule: evenodd;
|
||
}
|
||
</style>
|
||
</defs>
|
||
<title>GitHub</title>
|
||
<path class="cls-11" d="M151.36,47.28a105.76,105.76,0,0,0-33.43,206.1c5.28,1,7.22-2.3,7.22-5.09,0-2.52-.09-10.85-.14-19.69-29.42,6.4-35.63-12.48-35.63-12.48-4.81-12.22-11.74-15.47-11.74-15.47-9.59-6.56.73-6.43.73-6.43,10.61.75,16.21,10.9,16.21,10.9,9.43,16.17,24.73,11.49,30.77,8.79,1-6.83,3.69-11.5,6.71-14.14C108.57,197.1,83.88,188,83.88,147.51a40.92,40.92,0,0,1,10.9-28.39c-1.1-2.66-4.72-13.42,1-28,0,0,8.88-2.84,29.09,10.84a100.26,100.26,0,0,1,53,0C198,88.3,206.9,91.14,206.9,91.14c5.76,14.56,2.14,25.32,1,28a40.87,40.87,0,0,1,10.89,28.39c0,40.62-24.74,49.56-48.29,52.18,3.79,3.28,7.17,9.71,7.17,19.58,0,14.15-.12,25.54-.12,29,0,2.82,1.9,6.11,7.26,5.07A105.76,105.76,0,0,0,151.36,47.28Z">
|
||
</path>
|
||
<path class="cls-12" d="M85.66,199.12c-.23.52-1.06.68-1.81.32s-1.2-1.06-.95-1.59,1.06-.69,1.82-.33,1.21,1.07.94,1.6Zm-1.3-1">
|
||
</path>
|
||
<path class="cls-12" d="M90,203.89c-.51.47-1.49.25-2.16-.49a1.61,1.61,0,0,1-.31-2.19c.52-.47,1.47-.25,2.17.49s.82,1.72.3,2.19Zm-1-1.08">
|
||
</path>
|
||
<path class="cls-12" d="M94.12,210c-.65.46-1.71,0-2.37-.91s-.64-2.07,0-2.52,1.7,0,2.36.89.65,2.08,0,2.54Zm0,0"></path>
|
||
<path class="cls-12" d="M99.83,215.87c-.58.64-1.82.47-2.72-.41s-1.18-2.06-.6-2.7,1.83-.46,2.74.41,1.2,2.07.58,2.7Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M107.71,219.29c-.26.82-1.45,1.2-2.64.85s-2-1.34-1.74-2.17,1.44-1.23,2.65-.85,2,1.32,1.73,2.17Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M116.36,219.92c0,.87-1,1.59-2.24,1.61s-2.29-.68-2.3-1.54,1-1.59,2.26-1.61,2.28.67,2.28,1.54Zm0,0">
|
||
</path>
|
||
<path class="cls-12" d="M124.42,218.55c.15.85-.73,1.72-2,1.95s-2.37-.3-2.52-1.14.73-1.75,2-2,2.37.29,2.53,1.16Zm0,0"></path>
|
||
</svg></a>
|
||
<a class="footer-icon" id="footer_blog" href="https://ncbiinsights.ncbi.nlm.nih.gov/" aria-label="Blog">
|
||
<svg xmlns="http://www.w3.org/2000/svg" id="Layer_1" data-name="Layer 1" viewBox="0 0 40 40">
|
||
<defs><style>.cls-1{fill:#737373;}</style></defs>
|
||
<title>NCBI Insights Blog</title>
|
||
<path class="cls-1" d="M14,30a4,4,0,1,1-4-4,4,4,0,0,1,4,4Zm11,3A19,19,0,0,0,7.05,15a1,1,0,0,0-1,1v3a1,1,0,0,0,.93,1A14,14,0,0,1,20,33.07,1,1,0,0,0,21,34h3a1,1,0,0,0,1-1Zm9,0A28,28,0,0,0,7,6,1,1,0,0,0,6,7v3a1,1,0,0,0,1,1A23,23,0,0,1,29,33a1,1,0,0,0,1,1h3A1,1,0,0,0,34,33Z"></path>
|
||
</svg>
|
||
</a>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
|
||
<section class="container-fluid bg-primary">
|
||
<div class="container pt-5">
|
||
<div class="row mt-3">
|
||
<div class="col-lg-3 col-12">
|
||
<p><a class="text-white" href="https://www.nlm.nih.gov/socialmedia/index.html">Connect with NLM</a></p>
|
||
<ul class="list-inline social_media">
|
||
<li class="list-inline-item"><a href="https://twitter.com/NLM_NIH" aria-label="Twitter" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Twitter</title>
|
||
<g id="twitterx1009" clip-path="url(#clip0_65276_3946)">
|
||
<path id="Vector_Twitter" d="M17.5006 34.6565C26.9761 34.6565 34.6575 26.9751 34.6575 17.4996C34.6575 8.02416 26.9761 0.342773 17.5006 0.342773C8.02514 0.342773 0.34375 8.02416 0.34375 17.4996C0.34375 26.9751 8.02514 34.6565 17.5006 34.6565Z" fill="#205493" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
<path id="path1009" d="M8.54811 8.5L16.2698 18.4279L8.50001 26.5H11.5L17.5 20L22.5486 26.5H28.5L20.5 16L27 8.5H24.5L19 14.5L14.5007 8.5H8.54927H8.54811ZM11.1197 9.73873H13.4519L25.4519 25.2613H23.1926L11.1197 9.73873Z" fill="white"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_65276_3946">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.facebook.com/nationallibraryofmedicine" aria-label="Facebook" rel="noopener noreferrer" target="_blank">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Facebook</title>
|
||
<g id="Facebook" clip-path="url(#clip0_1717_1086)">
|
||
<path id="Vector_Facebook" d="M15.1147 29.1371C15.1147 29.0822 15.1147 29.0296 15.1147 28.9747V18.9414H11.8183C11.6719 18.9414 11.6719 18.9414 11.6719 18.8018C11.6719 17.5642 11.6719 16.3289 11.6719 15.0937C11.6719 14.9793 11.7062 14.9518 11.816 14.9518C12.8683 14.9518 13.9206 14.9518 14.9751 14.9518H15.1215V14.8329C15.1215 13.8057 15.1215 12.774 15.1215 11.7492C15.1274 10.9262 15.3148 10.1146 15.6706 9.37241C16.1301 8.38271 16.9475 7.60378 17.9582 7.19235C18.6492 6.90525 19.3923 6.76428 20.1405 6.7783C21.0029 6.79202 21.8653 6.83091 22.7278 6.86065C22.8879 6.86065 23.048 6.89496 23.2082 6.90182C23.2974 6.90182 23.3271 6.94071 23.3271 7.02993C23.3271 7.54235 23.3271 8.05477 23.3271 8.5649C23.3271 9.16882 23.3271 9.77274 23.3271 10.3767C23.3271 10.4819 23.2974 10.5139 23.1921 10.5116C22.5379 10.5116 21.8814 10.5116 21.2271 10.5116C20.9287 10.5184 20.6316 10.5528 20.3395 10.6146C20.0822 10.6619 19.8463 10.7891 19.6653 10.9779C19.4842 11.1668 19.3672 11.4078 19.3307 11.6669C19.2857 11.893 19.2612 12.1226 19.2575 12.3531C19.2575 13.1904 19.2575 14.0299 19.2575 14.8695C19.2575 14.8946 19.2575 14.9198 19.2575 14.9564H23.0229C23.1807 14.9564 23.183 14.9564 23.1624 15.1074C23.0778 15.7662 22.9885 16.425 22.9039 17.0816C22.8322 17.6321 22.7636 18.1827 22.698 18.7332C22.6729 18.9437 22.6797 18.9437 22.4693 18.9437H19.2644V28.8992C19.2644 28.9793 19.2644 29.0593 19.2644 29.1394L15.1147 29.1371Z" fill="white"></path>
|
||
<path id="Vector_2_Facebook" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1086">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
<li class="list-inline-item"><a href="https://www.youtube.com/user/NLMNIH" aria-label="Youtube" target="_blank" rel="noopener noreferrer">
|
||
<svg xmlns="http://www.w3.org/2000/svg" width="35" height="35" viewBox="0 0 36 35" fill="none">
|
||
<title>Youtube</title>
|
||
<g id="YouTube" clip-path="url(#clip0_1717_1101)">
|
||
<path id="Vector_Youtube" d="M26.2571 11.4791C25.9025 11.1589 25.5709 10.9576 24.228 10.834C22.5512 10.6785 20.2797 10.6556 18.564 10.6533H16.4365C14.7208 10.6533 12.4493 10.6785 10.7725 10.834C9.43196 10.9576 9.09798 11.1589 8.7434 11.4791C7.81464 12.321 7.6202 14.6268 7.59961 16.8938C7.59961 17.3178 7.59961 17.741 7.59961 18.1635C7.62706 20.4121 7.82837 22.686 8.7434 23.521C9.09798 23.8412 9.42967 24.0425 10.7725 24.1661C12.4493 24.3216 14.7208 24.3445 16.4365 24.3468H18.564C20.2797 24.3468 22.5512 24.3216 24.228 24.1661C25.5686 24.0425 25.9025 23.8412 26.2571 23.521C27.1722 22.6929 27.3735 20.451 27.4009 18.2206C27.4009 17.7402 27.4009 17.2599 27.4009 16.7795C27.3735 14.5491 27.1699 12.3072 26.2571 11.4791ZM15.5604 20.5311V14.652L20.561 17.5001L15.5604 20.5311Z" fill="white"></path>
|
||
<path id="Vector_2_Youtube" d="M17.5006 34.657C26.9761 34.657 34.6575 26.9756 34.6575 17.5001C34.6575 8.02465 26.9761 0.343262 17.5006 0.343262C8.02514 0.343262 0.34375 8.02465 0.34375 17.5001C0.34375 26.9756 8.02514 34.657 17.5006 34.657Z" stroke="white" stroke-width="1.0" stroke-miterlimit="10"></path>
|
||
</g>
|
||
<defs>
|
||
<clipPath id="clip0_1717_1101">
|
||
<rect width="35" height="35" fill="white"></rect>
|
||
</clipPath>
|
||
</defs>
|
||
</svg>
|
||
</a></li>
|
||
</ul>
|
||
</div>
|
||
<div class="col-lg-3 col-12">
|
||
<p class="address_footer text-white">National Library of Medicine<br />
|
||
<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
|
||
Bethesda, MD 20894</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
|
||
<a href="https://www.nih.gov/institutes-nih/nih-office-director/office-communications-public-liaison/freedom-information-act-office" class="text-white">FOIA</a><br />
|
||
<a href="https://www.hhs.gov/vulnerability-disclosure-policy/index.html" class="text-white" id="vdp">HHS Vulnerability Disclosure</a></p>
|
||
</div>
|
||
<div class="col-lg-3 col-12 centered-lg">
|
||
<p><a class="supportLink text-white" href="https://support.nlm.nih.gov/">Help</a><br />
|
||
<a href="https://www.nlm.nih.gov/accessibility.html" class="text-white">Accessibility</a><br />
|
||
<a href="https://www.nlm.nih.gov/careers/careers.html" class="text-white">Careers</a></p>
|
||
</div>
|
||
</div>
|
||
<div class="row">
|
||
<div class="col-lg-12 centered-lg">
|
||
<nav class="bottom-links">
|
||
<ul class="mt-3">
|
||
<li>
|
||
<a class="text-white" href="//www.nlm.nih.gov/">NLM</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.nih.gov/">NIH</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.hhs.gov/">HHS</a>
|
||
</li>
|
||
<li>
|
||
<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
|
||
</li>
|
||
</ul>
|
||
</nav>
|
||
</div>
|
||
</div>
|
||
</div>
|
||
</section>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/rlib/js/InstrumentOmnitureBaseJS/InstrumentNCBIConfigJS/InstrumentNCBIBaseJS/InstrumentPageStarterJS.js?v=1"> </script>
|
||
<script type="text/javascript" src="/portal/portal3rc.fcgi/static/js/hfjs2.js"> </script>
|
||
</div>
|
||
|
||
</div>
|
||
<div><input name="EntrezSystem2.PEntrez.DbConnector.Db" sid="1" type="hidden" value="pmc" /><input name="EntrezSystem2.PEntrez.DbConnector.LastDb" sid="1" type="hidden" value="pmc" /><input name="EntrezSystem2.PEntrez.DbConnector.Term" sid="1" type="hidden" value=""Expert Opin Orphan Drugs"[jour]" /><input name="EntrezSystem2.PEntrez.DbConnector.LastTabCmd" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastQueryKey" sid="1" type="hidden" value="90019" /><input name="EntrezSystem2.PEntrez.DbConnector.IdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LastIdsFromResult" sid="1" type="hidden" value="" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkReadableName" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.LinkSrcDb" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.Cmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.TabCmd" sid="1" type="hidden" /><input name="EntrezSystem2.PEntrez.DbConnector.QueryKey" sid="1" type="hidden" /></div>
|
||
<input type="hidden" name="p$a" id="p$a" /><input type="hidden" name="p$l" id="p$l" value="EntrezSystem2" /><input type="hidden" name="p$st" id="p$st" value="pmc" /><input name="SessionId" id="SessionId" value="CE8BC1E97D9F05E1_0182SID" disabled="disabled" type="hidden" /><input name="Snapshot" id="Snapshot" value="/projects/PMC/PMCEntrez@3.28" disabled="disabled" type="hidden" /></form>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<!-- CE8BC1E97D9F05E1_0182SID /projects/PMC/PMCEntrez@3.28 portal106 v4.1.r689238 Tue, Oct 22 2024 16:10:51 -->
|
||
<span id="portal-csrf-token" style="display:none" data-token="CE8BC1E97D9F05E1_0182SID"></span>
|
||
|
||
|
||
<script type='text/javascript' src='/portal/js/portal.js'></script><script type="text/javascript" src="//static.pubmed.gov/portal/portal3rc.fcgi/4213537/js/4200673/3812534/4087685/3812535/3781606/4120364/4191189/4080513/4181896/4186313/4191192/3758627/2146917/1053413/3812291/3908752/3423/1997347/3407051/3393413/4076482/31971/2084384/2020969/3924613/3890287/3798707/3397055/4001808.js" snapshot="pmc"></script></body>
|
||
</html> |