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<title>
Entry
- #619145 - SPERMATOGENIC FAILURE 50; SPGF50
- OMIM
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<span class="h4">#619145</span>
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<strong>Table of Contents</strong>
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<a href="#title"><strong>Title</strong></a>
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<a href="#phenotypeMap"><strong>Phenotype-Gene Relationships</strong></a>
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<a href="/clinicalSynopsis/619145"><strong>Clinical Synopsis</strong></a>
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<a href="/phenotypicSeries/PS258150"> <strong>Phenotypic Series</strong> </a>
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<a href="#text"><strong>Text</strong></a>
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<a href="#description">Description</a>
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<li role="presentation" style="margin-left: 1em">
<a href="#clinicalFeatures">Clinical Features</a>
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<li role="presentation" style="margin-left: 1em">
<a href="#inheritance">Inheritance</a>
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<li role="presentation" style="margin-left: 1em">
<a href="#mapping">Mapping</a>
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<li role="presentation" style="margin-left: 1em">
<a href="#molecularGenetics">Molecular Genetics</a>
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<a href="#references"><strong>References</strong></a>
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<a href="#creationDate"><strong>Creation Date</strong></a>
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<div><a href="https://clinicaltrials.gov/search?cond=(SPERMATOGENIC FAILURE) OR (XRCC2)" class="mim-tip-hint" title="Clinical Trials" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Clinical Trials', 'domain': 'clinicaltrials.gov'})">Clinical Trials</a></div>
<div><a href="https://www.orpha.net/consor/cgi-bin/ClinicalLabs_Search_Simple.php?lng=EN&LnkId=22775&Typ=Pat" class="mim-tip-hint" title="A list of European laboratories that offer genetic testing." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'EuroGentest', 'domain': 'orpha.net'})">EuroGentest</a></div>
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<div><a href="https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=399808" class="mim-tip-hint" title="European reference portal for information on rare diseases and orphan drugs." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'OrphaNet', 'domain': 'orpha.net'})">OrphaNet</a></div>
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<div><a href="https://www.alliancegenome.org/disease/DOID:0112272" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
<div><a href="http://www.informatics.jax.org/disease/619145" class="mim-tip-hint" title="Phenotypes, alleles, and disease models from Mouse Genome Informatics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Phenotype', 'domain': 'informatics.jax.org'})">MGI Mouse Phenotype</a></div>
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<a id="number" class="mim-anchor"></a>
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<a href="#" class="mim-tip-icd" qtip_title="<strong>ICD+</strong>" qtip_text="
<strong>ORPHA:</strong> 399808<br />
<strong>DO:</strong> 0112272<br />
">ICD+</a>
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<span class="h3">
<span class="mim-font mim-tip-hint" title="Phenotype description, molecular basis known">
<span class="text-danger"><strong>#</strong></span>
619145
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<a id="preferredTitle" class="mim-anchor"></a>
<h3>
<span class="mim-font">
SPERMATOGENIC FAILURE 50; SPGF50
</span>
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<br />
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<strong>Phenotype-Gene Relationships</strong>
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<table class="table table-bordered table-condensed table-hover small mim-table-padding">
<thead>
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Location
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Phenotype
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Phenotype <br /> MIM number
</th>
<th>
Inheritance
</th>
<th>
Phenotype <br /> mapping key
</th>
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Gene/Locus
</th>
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Gene/Locus <br /> MIM number
</th>
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<td>
<span class="mim-font">
<a href="/geneMap/7/844?start=-3&limit=10&highlight=844">
7q36.1
</a>
</span>
</td>
<td>
<span class="mim-font">
Spermatogenic failure 50
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619145"> 619145 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
XRCC2
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600375"> 600375 </a>
</span>
</td>
</tr>
</tbody>
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PheneGene Graphics <span class="caret"></span>
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<li><a href="/graph/linear/619145" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Linear'})"> Linear </a></li>
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<span class="glyphicon glyphicon-question-sign mim-tip-hint" title="OMIM PheneGene graphics depict relationships between phenotypes, groups of related phenotypes (Phenotypic Series), and genes.<br /><a href='/static/omim/pdf/OMIM_Graphics.pdf' target='_blank'>A quick reference overview and guide (PDF)</a>"></span>
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<div id="mimClinicalSynopsisFold" class="well well-sm collapse mimSingletonToggleFold">
<div class="small" style="margin: 5px">
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<span class="h5 mim-font">
<strong> INHERITANCE </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<span class="mim-font">
- Autosomal recessive <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/258211005" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">258211005</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0441748&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0441748</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000007" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000007</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000007" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000007</a>]</span><br />
</span>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> GENITOURINARY </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<div>
<span class="h5 mim-font">
<em> Internal Genitalia (Male) </em>
</span>
</div>
<div style="margin-left: 2em;">
<span class="mim-font">
- Infertility <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/8619003" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">8619003</a>, <a href="https://purl.bioontology.org/ontology/SNOMEDCT/15296000" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">15296000</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C4074771&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C4074771</a>, <a href="https://bioportal.bioontology.org/search?q=C0021359&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0021359</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000789" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000789</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000789" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000789</a>]</span><br /> -
Small testes <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/276411001" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">276411001</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0241355&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0241355</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0008734" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0008734</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0008734" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0008734</a>]</span><br /> -
Azoospermia <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/425558002" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">425558002</a>, <a href="https://purl.bioontology.org/ontology/SNOMEDCT/48188009" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">48188009</a>]</span> <span class="mim-feature-ids hidden">[ICD10CM: <a href="https://purl.bioontology.org/ontology/ICD10CM/N46.01" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">N46.01</a>, <a href="https://purl.bioontology.org/ontology/ICD10CM/N46.0" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">N46.0</a>]</span> <span class="mim-feature-ids hidden">[ICD9CM: <a href="https://purl.bioontology.org/ontology/ICD9CM/606.0" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">606.0</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0004509&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0004509</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000027" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000027</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000027" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000027</a>]</span><br /> -
Meiotic arrest at zygotene stage of prophase I <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C5563260&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C5563260</a>]</span><br />
</span>
</div>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> MOLECULAR BASIS </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<span class="mim-font">
- Caused by mutation in the X-ray repair, complementing defective, in Chinese hamster, 2 gene (XRCC2, <a href="/entry/600375#0002">600375.0002</a>)<br />
</span>
</div>
</div>
</div>
<div class="text-right">
<a href="#mimClinicalSynopsisFold" data-toggle="collapse">&#9650;&nbsp;Close</a>
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<div class="small">
<div class="row">
<div class="col-lg-12 col-md-12 col-sm-12 col-xs-12">
<h5>
Spermatogenic failure
- <a href="/phenotypicSeries/PS258150">PS258150</a>
- 110 Entries
</h5>
</div>
</div>
<div class="row" style="margin-left: 0.125em; margin-right: 0.125em;">
<table class="table table-bordered table-condensed table-hover mim-table-padding">
<thead>
<tr>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Location</strong>
</th>
<th class="col-lg-5 col-md-5 col-sm-5 col-xs-6 text-nowrap">
<strong>Phenotype</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Inheritance</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Phenotype<br />mapping key</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Phenotype<br />MIM number</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Gene/Locus</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Gene/Locus<br />MIM number</strong>
</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/451?start=-3&limit=10&highlight=451"> 1p34.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620354"> Spermatogenic failure 83 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620354"> 620354 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602135"> DNALI1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602135"> 602135 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/516?start=-3&limit=10&highlight=516"> 1p34.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620917"> Spermatogenic failure 95 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620917"> 620917 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614259"> CFAP57 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614259"> 614259 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/729?start=-3&limit=10&highlight=729"> 1p31.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/108420"> Spermatogenic failure 2 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/108420"> 108420 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602105"> MSH4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602105"> 602105 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/796?start=-3&limit=10&highlight=796"> 1p22.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617644"> ?Spermatogenic failure 21 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617644"> 617644 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602144"> BRDT </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602144"> 602144 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/969?start=-3&limit=10&highlight=969"> 1p12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619380"> ?Spermatogenic failure 55 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619380"> 619380 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616554"> SPAG17 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616554"> 616554 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/1183?start=-3&limit=10&highlight=1183"> 1q21.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621057"> ?Spermatogenic failure 97 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621057"> 621057 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621033"> NUP210L </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621033"> 621033 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/107?start=-3&limit=10&highlight=107"> 2p23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620222"> Spermatogenic failure 80 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620222"> 620222 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615288"> DRC1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615288"> 615288 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/392?start=-3&limit=10&highlight=392"> 2p13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619108"> Spermatogenic failure 48 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619108"> 619108 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619098"> M1AP </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619098"> 619098 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/499?start=-3&limit=10&highlight=499"> 2q11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617961"> ?Spermatogenic failure 26 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617961"> 617961 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607166"> TSGA10 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607166"> 607166 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/846?start=-3&limit=10&highlight=846"> 2q32.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618153"> Spermatogenic failure 34 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618153"> 618153 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615796"> FSIP2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615796"> 615796 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/918?start=-3&limit=10&highlight=918"> 2q33.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619805"> ?Spermatogenic failure 68 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619805"> 619805 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619776"> C2CD6 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619776"> 619776 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/1005?start=-3&limit=10&highlight=1005"> 2q35 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619379"> ?Spermatogenic failure 54 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619379"> 619379 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619387"> CATIP </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619387"> 619387 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/1026?start=-3&limit=10&highlight=1026"> 2q35 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618664"> Spermatogenic failure 40 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618664"> 618664 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614270"> CFAP65 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614270"> 614270 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/186?start=-3&limit=10&highlight=186"> 3p22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618429"> Spermatogenic failure 37 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618429"> 618429 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611430"> TTC21A </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611430"> 611430 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/373?start=-3&limit=10&highlight=373"> 3p21.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617576"> Spermatogenic failure 18 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617576"> 617576 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603332"> DNAH1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603332"> 603332 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/552?start=-3&limit=10&highlight=552"> 3q13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617593"> Spermatogenic failure 20 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617593"> 617593 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617559"> CFAP44 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617559"> 617559 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/579?start=-3&limit=10&highlight=579"> 3q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619177"> Spermatogenic failure 51 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619177"> 619177 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609910"> CFAP91 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609910"> 609910 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/870?start=-3&limit=10&highlight=870"> 3q26.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/102530"> ?Spermatogenic failure 6 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/102530"> 102530 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609856"> SPATA16 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609856"> 609856 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/24?start=-3&limit=10&highlight=24"> 4p16.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619673"> ?Spermatogenic failure 62 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619673"> 619673 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612041"> RNF212 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612041"> 612041 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/157?start=-3&limit=10&highlight=157"> 4p14 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619867"> ?Spermatogenic failure 72 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619867"> 619867 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608151"> WDR19 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608151"> 608151 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/242?start=-3&limit=10&highlight=242"> 4q12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618091"> ?Spermatogenic failure 29 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618091"> 618091 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605753"> SPINK2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605753"> 605753 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/421?start=-3&limit=10&highlight=421"> 4q22.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619828"> Spermatogenic failure 70 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619828"> 619828 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/179061"> PDHA2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/179061"> 179061 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/594?start=-3&limit=10&highlight=594"> 4q31.22 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618745"> Spermatogenic failure 42 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618745"> 618745 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618735"> TTC29 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618735"> 618735 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/105?start=-3&limit=10&highlight=105"> 5p13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618751"> Spermatogenic failure 43 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618751"> 618751 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610172"> SPEF2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610172"> 610172 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/331?start=-3&limit=10&highlight=331"> 6p21.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619937"> Spermatogenic failure 74 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619937"> 619937 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603382"> MSH5 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603382"> 603382 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/432?start=-3&limit=10&highlight=432"> 6p21.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620744"> Spermatogenic failure 90 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620744"> 620744 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620377"> ARMC12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620377"> 620377 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/436?start=-3&limit=10&highlight=436"> 6p21.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606766"> Spermatogenic failure 3 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>, <abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606766"> 606766 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608480"> SLC26A8 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608480"> 608480 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/461?start=-3&limit=10&highlight=461"> 6p21.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619095"> Spermatogenic failure 46 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619095"> 619095 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603337"> DNAH8 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603337"> 603337 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/697?start=-3&limit=10&highlight=697"> 6q15 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620490"> ?Spermatogenic failure 85 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620490"> 620490 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612739"> SPACA1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612739"> 612739 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/762?start=-3&limit=10&highlight=762"> 6q21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618433"> Spermatogenic failure 38 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618433"> 618433 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618424"> ARMC2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618424"> 618424 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/768?start=-3&limit=10&highlight=768"> 6q21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620705"> Spermatogenic failure 89 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620705"> 620705 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615358"> AK9 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615358"> 615358 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/997?start=-3&limit=10&highlight=997"> 6q25.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619528"> Spermatogenic failure 57 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619528"> 619528 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619529"> PNLDC1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619529"> 619529 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/261?start=-3&limit=10&highlight=261"> 7p12.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619799"> ?Spermatogenic failure 66 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619799"> 619799 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608498"> ZPBP </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608498"> 608498 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/315?start=-3&limit=10&highlight=315"> 7q11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620103"> Spermatogenic failure 77 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620103"> 620103 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604839"> FKBP6 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604839"> 604839 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/362?start=-3&limit=10&highlight=362"> 7q11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620850"> Spermatogenic failure 94 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620850"> 620850 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619829"> CCDC146 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619829"> 619829 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/398?start=-3&limit=10&highlight=398"> 7q21.13 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617959"> Spermatogenic failure 24 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617959"> 617959 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617949"> CFAP69 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617949"> 617949 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/492?start=-3&limit=10&highlight=492"> 7q22.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619672"> Spermatogenic failure 61 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619672"> 619672 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608489"> STAG3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608489"> 608489 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/844?start=-3&limit=10&highlight=844"> 7q36.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619145"> Spermatogenic failure 50 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619145"> 619145 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600375"> XRCC2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600375"> 600375 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/183?start=-3&limit=10&highlight=183"> 8p12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617960"> Spermatogenic failure 25 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617960"> 617960 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605795"> TEX15 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605795"> 605795 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/194?start=-3&limit=10&highlight=194"> 8p11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620196"> Spermatogenic failure 79 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620196"> 620196 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615215"> KCNU1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615215"> 615215 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/440?start=-3&limit=10&highlight=440"> 8q22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619696"> Spermatogenic failure 64 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619696"> 619696 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609110"> FBXO43 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609110"> 609110 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/111?start=-3&limit=10&highlight=111"> 9p21.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619585"> Spermatogenic failure 58 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619585"> 619585 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608040"> IFT74 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608040"> 608040 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/185?start=-3&limit=10&highlight=185"> 9p13.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620838"> Spermatogenic failure 91 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620838"> 620838 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603960"> CCIN </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603960"> 603960 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/396?start=-3&limit=10&highlight=396"> 9q31.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620499"> Spermatogenic failure 86 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620499"> 620499 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604303"> ACTL7A </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604303"> 604303 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/414?start=-3&limit=10&highlight=414"> 9q31.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619949"> Spermatogenic failure 75 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619949"> 619949 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618038"> SHOC1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618038"> 618038 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/489?start=-3&limit=10&highlight=489"> 9q33.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613957"> Spermatogenic failure 8 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613957"> 613957 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/184757"> NR5A1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/184757"> 184757 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/641?start=-3&limit=10&highlight=641"> 9q34.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618115"> Spermatogenic failure 32 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618115"> 618115 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610224"> SOHLH1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610224"> 610224 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/10/300?start=-3&limit=10&highlight=300"> 10q22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618670"> ?Spermatogenic failure 41 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618670"> 618670 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618661"> CFAP70 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618661"> 618661 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/10/547?start=-3&limit=10&highlight=547"> 10q25.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617592"> Spermatogenic failure 19 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617592"> 617592 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617558"> CFAP43 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617558"> 617558 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/10/551?start=-3&limit=10&highlight=551"> 10q25.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619144"> Spermatogenic failure 49 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619144"> 619144 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619129"> CFAP58 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619129"> 619129 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/10/606?start=-3&limit=10&highlight=606"> 10q26.11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615413"> Spermatogenic failure 12 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615413"> 615413 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608226"> NANOS1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608226"> 608226 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/10/684?start=-3&limit=10&highlight=684"> 10q26.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616950"> ?Spermatogenic failure 15 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616950"> 616950 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611486"> SYCE1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611486"> 611486 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/132?start=-3&limit=10&highlight=132"> 11p15.4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619712"> Spermatogenic failure 65 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619712"> 619712 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617277"> DNHD1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617277"> 617277 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/155?start=-3&limit=10&highlight=155"> 11p15.4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620849"> ?Spermatogenic failure 93 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620849"> 620849 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607670"> STK33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607670"> 607670 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/256?start=-3&limit=10&highlight=256"> 11p14.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620084"> Spermatogenic failure 76 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620084"> 620084 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612324"> CCDC34 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612324"> 612324 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/621?start=-3&limit=10&highlight=621"> 11q13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612997"> Spermatogenic failure 7 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612997"> 612997 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606389"> CATSPER1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606389"> 606389 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/37?start=-3&limit=10&highlight=37"> 12p13.32 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620353"> Spermatogenic failure 82 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620353"> 620353 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604689"> AKAP3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604689"> 604689 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/77?start=-3&limit=10&highlight=77"> 12p13.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620848"> Spermatogenic failure 92 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620848"> 620848 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620708"> LRRC23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620708"> 620708 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/211?start=-3&limit=10&highlight=211"> 12p12.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617214"> Spermatogenic failure 17 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617214"> 617214 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608075"> PLCZ1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608075"> 608075 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/576?start=-3&limit=10&highlight=576"> 12q14.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613958"> Spermatogenic failure 9 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613958"> 613958 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613893"> DPY19L2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613893"> 613893 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/708?start=-3&limit=10&highlight=708"> 12q23.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621124"> Spermatogenic failure 98 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621124"> 621124 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621121"> CFAP54 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621121"> 621121 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/730?start=-3&limit=10&highlight=730"> 12q23.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/270960"> Spermatogenic failure 4 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/270960"> 270960 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604759"> SYCP3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604759"> 604759 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/730?start=-3&limit=10&highlight=730"> 12q23.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/270960"> Pregnancy loss, recurrent, 4 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/270960"> 270960 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604759"> SYCP3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604759"> 604759 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/901?start=-3&limit=10&highlight=901"> 12q24.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618152"> Spermatogenic failure 33 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618152"> 618152 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618146"> WDR66 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618146"> 618146 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/916?start=-3&limit=10&highlight=916"> 12q24.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619803"> ?Spermatogenic failure 67 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619803"> 619803 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613481"> CCDC62 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613481"> 613481 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/936?start=-3&limit=10&highlight=936"> 12q24.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619515"> Spermatogenic failure 56 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619515"> 619515 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605884"> DNAH10 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605884"> 605884 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/13/268?start=-3&limit=10&highlight=268"> 13q32.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619102"> Spermatogenic failure 47 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619102"> 619102 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608671"> DZIP1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608671"> 608671 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/168?start=-3&limit=10&highlight=168"> 14q13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618420"> Spermatogenic failure 36 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618420"> 618420 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615902"> PPP2R3C </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615902"> 615902 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/200?start=-3&limit=10&highlight=200"> 14q21.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618086"> Spermatogenic failure 28 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618086"> 618086 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609644"> FANCM </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609644"> 609644 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/202?start=-3&limit=10&highlight=202"> 14q21.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619689"> ?Spermatogenic failure 63 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619689"> 619689 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619655"> RPL10L </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619655"> 619655 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/285?start=-3&limit=10&highlight=285"> 14q23.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619202"> Spermatogenic failure 52 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619202"> 619202 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617307"> C14orf39 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617307"> 617307 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/512?start=-3&limit=10&highlight=512"> 14q32.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617965"> ?Spermatogenic failure 27 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617965"> 617965 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615364"> AK7 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615364"> 615364 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/585?start=-3&limit=10&highlight=585"> 14q32.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618110"> ?Spermatogenic failure 30 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618110"> 618110 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617963"> TDRD9 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617963"> 617963 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/15/172?start=-3&limit=10&highlight=172"> 15q21.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619645"> ?Spermatogenic failure 59 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619645"> 619645 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617131"> TERB2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617131"> 617131 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/79?start=-3&limit=10&highlight=79"> 16p13.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617706"> Spermatogenic failure 22 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617706"> 617706 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617670"> MEIOB </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617670"> 617670 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/165?start=-3&limit=10&highlight=165"> 16p13.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614822"> Spermatogenic failure 10 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614822"> 614822 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611562"> SEPTIN12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611562"> 611562 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/523?start=-3&limit=10&highlight=523"> 16q22.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619646"> Spermatogenic failure 60 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619646"> 619646 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617332"> TERB1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617332"> 617332 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/629?start=-3&limit=10&highlight=629"> 16q22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618112"> Spermatogenic failure 31 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618112"> 618112 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618085"> PMFBP1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618085"> 618085 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/57?start=-3&limit=10&highlight=57"> 17p13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621001"> Spermatogenic failure 96 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621001"> 621001 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617673"> SPATA22 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617673"> 617673 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/84?start=-3&limit=10&highlight=84"> 17p13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615842"> ?Spermatogenic failure 14 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615842"> 615842 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614312"> ZMYND15 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614312"> 614312 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/178?start=-3&limit=10&highlight=178"> 17p13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619094"> Spermatogenic failure 45 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619094"> 619094 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603333"> DNAH2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603333"> 603333 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/245?start=-3&limit=10&highlight=245"> 17p12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620277"> Spermatogenic failure 81 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620277"> 620277 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612683"> TEKT3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612683"> 612683 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/250?start=-3&limit=10&highlight=250"> 17p12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619831"> Spermatogenic failure 71 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619831"> 619831 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614535"> ZSWIM7 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614535"> 614535 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/559?start=-3&limit=10&highlight=559"> 17q21.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615081"> Spermatogenic failure 11 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615081"> 615081 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608778"> KLHL10 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608778"> 608778 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/791?start=-3&limit=10&highlight=791"> 17q22 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617707"> Spermatogenic failure 23 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617707"> 617707 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605792"> TEX14 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605792"> 605792 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/865?start=-3&limit=10&highlight=865"> 17q24.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619044"> Spermatogenic failure 44 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619044"> 619044 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618980"> CEP112 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618980"> 618980 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/970?start=-3&limit=10&highlight=970"> 17q25.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618341"> Spermatogenic failure 35 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618341"> 618341 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618304"> QRICH2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618304"> 618304 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/999?start=-3&limit=10&highlight=999"> 17q25.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618643"> Spermatogenic failure 39 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618643"> 618643 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610063"> DNAH17 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610063"> 610063 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/18/104?start=-3&limit=10&highlight=104"> 18q11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615841"> ?Spermatogenic failure 13 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615841"> 615841 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601689"> TAF4B </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601689"> 601689 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/240?start=-3&limit=10&highlight=240"> 19p13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619258"> Spermatogenic failure 53 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619258"> 619258 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619251"> ACTL9 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619251"> 619251 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/458?start=-3&limit=10&highlight=458"> 19p13.11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620170"> Spermatogenic failure 78 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620170"> 620170 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620160"> IQCN </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620160"> 620160 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/646?start=-3&limit=10&highlight=646"> 19q13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619826"> Spermatogenic failure 69 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619826"> 619826 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609966"> GGN </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609966"> 609966 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/941?start=-3&limit=10&highlight=941"> 19q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620547"> Spermatogenic failure 88 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620547"> 620547 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618125"> KASH5 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618125"> 618125 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/1203?start=-3&limit=10&highlight=1203"> 19q13.43 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/243060"> Spermatogenic failure 5 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/243060"> 243060 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603495"> AURKC </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603495"> 603495 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/132?start=-3&limit=10&highlight=132"> 20p11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620409"> Spermatogenic failure 84 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620409"> 620409 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620381"> CFAP61 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620381"> 620381 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/205?start=-3&limit=10&highlight=205"> 20q11.21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617187"> Spermatogenic failure 16 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617187"> 617187 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613942"> SUN5 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613942"> 613942 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/435?start=-3&limit=10&highlight=435"> 20q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/258150"> Spermatogenic failure 1 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/258150"> 258150 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604105"> SYCP2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604105"> 604105 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/402?start=-3&limit=10&highlight=402"> 22q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619878"> ?Spermatogenic failure 73 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619878"> 619878 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605794"> MOV10L1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605794"> 605794 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/425?start=-3&limit=10&highlight=425"> 22q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620500"> ?Spermatogenic failure 87 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620500"> 620500 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/102480"> ACR </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/102480"> 102480 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/93?start=-3&limit=10&highlight=93"> Xp22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301137"> Spermatogenic failure, X-linked, 9 </a>
</span>
</td>
<td>
<span class="mim-font">
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301137"> 301137 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300825"> RBBP7 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300825"> 300825 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/153?start=-3&limit=10&highlight=153"> Xp21.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301059"> Spermatogenic failure, X-linked 3 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301059"> 301059 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301057"> CFAP47 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301057"> 301057 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/242?start=-3&limit=10&highlight=242"> Xp11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301099"> Spermatogenic failure, X-linked, 5 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked">XL</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301099"> 301099 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/312820"> SSX1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/312820"> 312820 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/399?start=-3&limit=10&highlight=399"> Xq13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/309120"> Spermatogenic failure, X-linked 2 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/309120"> 309120 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300311"> TEX11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300311"> 300311 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/413?start=-3&limit=10&highlight=413"> Xq13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301077"> Spermatogenic failure, X-linked, 4 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked">XL</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301077"> 301077 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300369"> GCNA </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300369"> 300369 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/466?start=-3&limit=10&highlight=466"> Xq21.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301119"> {Spermatogenic failure, X-linked, 8, susceptibility to} </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked">XL</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301119"> 301119 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300768"> CYLC1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300768"> 300768 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/688?start=-3&limit=10&highlight=688"> Xq26.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301101"> Spermatogenic failure, X-linked, 6 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked">XL</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301101"> 301101 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300309"> USP26 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300309"> 300309 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/706?start=-3&limit=10&highlight=706"> Xq26.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301106"> ?Spermatogenic failure, X-linked, 7 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301106"> 301106 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301105"> CT55 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301105"> 301105 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/Y/22?start=-3&limit=10&highlight=22"> Yq11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/400042"> Spermatogenic failure, Y-linked, 1 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Y-linked">YL</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="4 - A contiguous gene duplication or deletion syndrome in which multiple genes are involved"> 4 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/400042"> 400042 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/400042"> DELYq11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/400042"> 400042 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/Y/24?start=-3&limit=10&highlight=24"> Yq11.221 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/415000"> Spermatogenic failure, Y-linked, 2 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Y-linked">YL</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/415000"> 415000 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/400005"> USP9Y </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/400005"> 400005 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
Not Mapped
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/305700"> Spermatogenic failure, X-linked 1 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked">XL</abbr>
</span>
</td>
<td>
<span class="mim-font">
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/305700"> 305700 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/305700"> SPGFX1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/305700"> 305700 </a>
</span>
</td>
</tr>
</tbody>
</table>
</div>
<div class="text-right small">
<a href="#mimPhenotypicSeriesFold" data-toggle="collapse">&#9650;&nbsp;Close</a>
</div>
</div>
</div>
</div>
<div>
<br />
</div>
<div>
<a id="text" class="mim-anchor"></a>
<h4 href="#mimTextFold" id="mimTextToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimTextToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<span class="mim-tip-floating" qtip_title="<strong>Looking For More References?</strong>" qtip_text="Click the 'reference plus' icon &lt;span class='glyphicon glyphicon-plus-sign'&gt;&lt;/span&gt at the end of each OMIM text paragraph to see more references related to the content of the preceding paragraph.">
<strong>TEXT</strong>
</span>
</span>
</h4>
<div id="mimTextFold" class="collapse in ">
<span class="mim-text-font">
<p>A number sign (#) is used with this entry because of evidence that spermatogenic failure-50 (SPGF50) is caused by homozygous mutation in the XRCC2 gene (<a href="/entry/600375">600375</a>) on chromosome 7q36.</p><p>Homozygous mutation in XRCC2 has also been reported in premature ovarian failure (see POF17, <a href="/entry/619146">619146</a>).</p>
</span>
<div>
<br />
</div>
</div>
<div>
<a id="description" class="mim-anchor"></a>
<h4 href="#mimDescriptionFold" id="mimDescriptionToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimDescriptionToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<strong>Description</strong>
</span>
</h4>
</div>
<div id="mimDescriptionFold" class="collapse in ">
<span class="mim-text-font">
<p>Spermatogenic failure-50 (SPGF50) is characterized by male infertility due to azoospermia resulting from meiotic arrest at prophase I (<a href="#1" class="mim-tip-reference" title="Yang, Y., Guo, J., Dai, L., Zhu, Y., Hu, H., Tan, L., Chen, W., Liang, D., He, J., Tu, M., Wang, K., Wu, L. &lt;strong&gt;XRCC2 mutation causes meiotic arrest, azoospermia and infertility.&lt;/strong&gt; J. Med. Genet. 55: 628-636, 2018.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/30042186/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;30042186&lt;/a&gt;, &lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pmc/?term=30042186[PMID]&amp;report=imagesdocsum&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed Image&#x27;, &#x27;domain&#x27;: &#x27;ncbi.nlm.nih.gov&#x27;})&quot;&gt;images&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1136/jmedgenet-2017-105145&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="30042186">Yang et al., 2018</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30042186" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>For a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (<a href="/entry/258150">258150</a>).</p>
</span>
<div>
<br />
</div>
</div>
<div>
<a id="clinicalFeatures" class="mim-anchor"></a>
<h4 href="#mimClinicalFeaturesFold" id="mimClinicalFeaturesToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimClinicalFeaturesToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<strong>Clinical Features</strong>
</span>
</h4>
</div>
<div id="mimClinicalFeaturesFold" class="collapse in mimTextToggleFold">
<span class="mim-text-font">
<p><a href="#1" class="mim-tip-reference" title="Yang, Y., Guo, J., Dai, L., Zhu, Y., Hu, H., Tan, L., Chen, W., Liang, D., He, J., Tu, M., Wang, K., Wu, L. &lt;strong&gt;XRCC2 mutation causes meiotic arrest, azoospermia and infertility.&lt;/strong&gt; J. Med. Genet. 55: 628-636, 2018.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/30042186/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;30042186&lt;/a&gt;, &lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pmc/?term=30042186[PMID]&amp;report=imagesdocsum&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed Image&#x27;, &#x27;domain&#x27;: &#x27;ncbi.nlm.nih.gov&#x27;})&quot;&gt;images&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1136/jmedgenet-2017-105145&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="30042186">Yang et al. (2018)</a> studied 2 infertile brothers, born of first-cousin parents, from a Tujia ethnic minority family in China. Small testes had been noted at ages 10 and 12 years, and testes were still small at ages 29 and 31. Both were azoospermic, with no sperm observed on percutaneous epididymal sperm aspiration. Testicular biopsy confirmed the absence of sperm and showed meiotic arrest at the zygotene stage of prophase I. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30042186" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#2" class="mim-tip-reference" title="Zhang, Y.-X., Li, H.-Y., He, W.-B., Tu, C., Du, J., Li, W., Lu, G.-X., Lin, G., Yang, Y., Tan, Y.-Q. &lt;strong&gt;XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.&lt;/strong&gt; Clin. Genet. 95: 442-443, 2019.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/30489636/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;30489636&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1111/cge.13475&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="30489636">Zhang et al. (2019)</a> reported a consanguineous Chinese family in which a 31-year-old man was infertile due to complete azoospermia; only primary spermatocytes were observed on testicular biopsy. He had normal testicular size and normal hormone levels. His 29-year-old sister had premature ovarian failure (see POF17, <a href="/entry/619146">619146</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30489636" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
</span>
<div>
<br />
</div>
</div>
<div>
<a id="inheritance" class="mim-anchor"></a>
<h4 href="#mimInheritanceFold" id="mimInheritanceToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimInheritanceToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<strong>Inheritance</strong>
</span>
</h4>
</div>
<div id="mimInheritanceFold" class="collapse in mimTextToggleFold">
<span class="mim-text-font">
<p>The transmission pattern of SPGF50 in the family studied by <a href="#1" class="mim-tip-reference" title="Yang, Y., Guo, J., Dai, L., Zhu, Y., Hu, H., Tan, L., Chen, W., Liang, D., He, J., Tu, M., Wang, K., Wu, L. &lt;strong&gt;XRCC2 mutation causes meiotic arrest, azoospermia and infertility.&lt;/strong&gt; J. Med. Genet. 55: 628-636, 2018.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/30042186/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;30042186&lt;/a&gt;, &lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pmc/?term=30042186[PMID]&amp;report=imagesdocsum&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed Image&#x27;, &#x27;domain&#x27;: &#x27;ncbi.nlm.nih.gov&#x27;})&quot;&gt;images&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1136/jmedgenet-2017-105145&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="30042186">Yang et al. (2018)</a> was consistent with autosomal recessive inheritance. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30042186" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
</span>
<div>
<br />
</div>
</div>
<div>
<a id="mapping" class="mim-anchor"></a>
<h4 href="#mimMappingFold" id="mimMappingToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimMappingToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<strong>Mapping</strong>
</span>
</h4>
</div>
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<p><a href="#1" class="mim-tip-reference" title="Yang, Y., Guo, J., Dai, L., Zhu, Y., Hu, H., Tan, L., Chen, W., Liang, D., He, J., Tu, M., Wang, K., Wu, L. &lt;strong&gt;XRCC2 mutation causes meiotic arrest, azoospermia and infertility.&lt;/strong&gt; J. Med. Genet. 55: 628-636, 2018.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/30042186/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;30042186&lt;/a&gt;, &lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pmc/?term=30042186[PMID]&amp;report=imagesdocsum&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed Image&#x27;, &#x27;domain&#x27;: &#x27;ncbi.nlm.nih.gov&#x27;})&quot;&gt;images&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1136/jmedgenet-2017-105145&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="30042186">Yang et al. (2018)</a> performed homozygosity mapping in a consanguineous Chinese family with male infertility and identified 4 homozygous intervals totaling 35.2 Mb, at 2q26.1-q36.3, 7q36.1-qter, 13q12.1-q14.1, and 19p13.2-19p13.3. None of the regions showed overlap with previously described loci associated with azoospermia, meiotic arrest, and infertility. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30042186" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<strong>Molecular Genetics</strong>
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<p>By whole-exome sequencing in a consanguineous Chinese family in which 2 brothers were infertile due to azoospermia, <a href="#1" class="mim-tip-reference" title="Yang, Y., Guo, J., Dai, L., Zhu, Y., Hu, H., Tan, L., Chen, W., Liang, D., He, J., Tu, M., Wang, K., Wu, L. &lt;strong&gt;XRCC2 mutation causes meiotic arrest, azoospermia and infertility.&lt;/strong&gt; J. Med. Genet. 55: 628-636, 2018.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/30042186/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;30042186&lt;/a&gt;, &lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pmc/?term=30042186[PMID]&amp;report=imagesdocsum&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed Image&#x27;, &#x27;domain&#x27;: &#x27;ncbi.nlm.nih.gov&#x27;})&quot;&gt;images&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1136/jmedgenet-2017-105145&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="30042186">Yang et al. (2018)</a> identified homozygosity for a missense mutation in the XRCC2 gene (L14P; <a href="/entry/600375#0002">600375.0002</a>) that segregated with disease in the family. The authors noted that XRCC2 is located within 1 of the previously identified regions of homozygosity in the 2 affected brothers. Direct sequencing of XRCC2 in 127 unrelated infertile Chinese men with nonobstructive azoospermia did not detect any mutations. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30042186" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>By whole-exome sequencing in a 31-year-old Chinese man with infertility due to azoospermia and his 29-year-old sister with POF, <a href="#2" class="mim-tip-reference" title="Zhang, Y.-X., Li, H.-Y., He, W.-B., Tu, C., Du, J., Li, W., Lu, G.-X., Lin, G., Yang, Y., Tan, Y.-Q. &lt;strong&gt;XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.&lt;/strong&gt; Clin. Genet. 95: 442-443, 2019.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/30489636/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;30489636&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1111/cge.13475&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="30489636">Zhang et al. (2019)</a> identified homozygosity for the L14P mutation in the XRCC2 gene, for which their unaffected first-cousin parents were heterozygous. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30489636" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<strong>REFERENCES</strong>
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<a id="1" class="mim-anchor"></a>
<a id="Yang2018" class="mim-anchor"></a>
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Yang, Y., Guo, J., Dai, L., Zhu, Y., Hu, H., Tan, L., Chen, W., Liang, D., He, J., Tu, M., Wang, K., Wu, L.
<strong>XRCC2 mutation causes meiotic arrest, azoospermia and infertility.</strong>
J. Med. Genet. 55: 628-636, 2018.
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/30042186/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">30042186</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=30042186[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30042186" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
[<a href="https://doi.org/10.1136/jmedgenet-2017-105145" target="_blank">Full Text</a>]
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<a id="Zhang2019" class="mim-anchor"></a>
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<p class="mim-text-font">
Zhang, Y.-X., Li, H.-Y., He, W.-B., Tu, C., Du, J., Li, W., Lu, G.-X., Lin, G., Yang, Y., Tan, Y.-Q.
<strong>XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.</strong>
Clin. Genet. 95: 442-443, 2019.
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/30489636/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">30489636</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=30489636" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
[<a href="https://doi.org/10.1111/cge.13475" target="_blank">Full Text</a>]
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Marla J. F. O&#x27;Neill : 12/30/2020
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carol : 03/03/2021
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alopez : 02/08/2021<br>alopez : 12/30/2020
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<strong>#</strong> 619145
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<h3>
<span class="mim-font">
SPERMATOGENIC FAILURE 50; SPGF50
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<span class="mim-text-font">
<strong>ORPHA:</strong> 399808; &nbsp;
<strong>DO:</strong> 0112272; &nbsp;
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<h4>
<span class="mim-font">
<strong>Phenotype-Gene Relationships</strong>
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<table class="table table-bordered table-condensed small mim-table-padding">
<thead>
<tr class="active">
<th>
Location
</th>
<th>
Phenotype
</th>
<th>
Phenotype <br /> MIM number
</th>
<th>
Inheritance
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<th>
Phenotype <br /> mapping key
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Gene/Locus
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Gene/Locus <br /> MIM number
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7q36.1
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Spermatogenic failure 50
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<td>
<span class="mim-font">
619145
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<span class="mim-font">
Autosomal recessive
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3
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XRCC2
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<span class="mim-font">
600375
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<span class="mim-font">
<strong>TEXT</strong>
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<p>A number sign (#) is used with this entry because of evidence that spermatogenic failure-50 (SPGF50) is caused by homozygous mutation in the XRCC2 gene (600375) on chromosome 7q36.</p><p>Homozygous mutation in XRCC2 has also been reported in premature ovarian failure (see POF17, 619146).</p>
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<strong>Description</strong>
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<p>Spermatogenic failure-50 (SPGF50) is characterized by male infertility due to azoospermia resulting from meiotic arrest at prophase I (Yang et al., 2018). </p><p>For a discussion of genetic heterogeneity of spermatogenic failure, see SPGF1 (258150).</p>
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<span class="mim-font">
<strong>Clinical Features</strong>
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<p>Yang et al. (2018) studied 2 infertile brothers, born of first-cousin parents, from a Tujia ethnic minority family in China. Small testes had been noted at ages 10 and 12 years, and testes were still small at ages 29 and 31. Both were azoospermic, with no sperm observed on percutaneous epididymal sperm aspiration. Testicular biopsy confirmed the absence of sperm and showed meiotic arrest at the zygotene stage of prophase I. </p><p>Zhang et al. (2019) reported a consanguineous Chinese family in which a 31-year-old man was infertile due to complete azoospermia; only primary spermatocytes were observed on testicular biopsy. He had normal testicular size and normal hormone levels. His 29-year-old sister had premature ovarian failure (see POF17, 619146). </p>
</span>
<div>
<br />
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<h4>
<span class="mim-font">
<strong>Inheritance</strong>
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<span class="mim-text-font">
<p>The transmission pattern of SPGF50 in the family studied by Yang et al. (2018) was consistent with autosomal recessive inheritance. </p>
</span>
<div>
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<h4>
<span class="mim-font">
<strong>Mapping</strong>
</span>
</h4>
</div>
<span class="mim-text-font">
<p>Yang et al. (2018) performed homozygosity mapping in a consanguineous Chinese family with male infertility and identified 4 homozygous intervals totaling 35.2 Mb, at 2q26.1-q36.3, 7q36.1-qter, 13q12.1-q14.1, and 19p13.2-19p13.3. None of the regions showed overlap with previously described loci associated with azoospermia, meiotic arrest, and infertility. </p>
</span>
<div>
<br />
</div>
<div>
<h4>
<span class="mim-font">
<strong>Molecular Genetics</strong>
</span>
</h4>
</div>
<span class="mim-text-font">
<p>By whole-exome sequencing in a consanguineous Chinese family in which 2 brothers were infertile due to azoospermia, Yang et al. (2018) identified homozygosity for a missense mutation in the XRCC2 gene (L14P; 600375.0002) that segregated with disease in the family. The authors noted that XRCC2 is located within 1 of the previously identified regions of homozygosity in the 2 affected brothers. Direct sequencing of XRCC2 in 127 unrelated infertile Chinese men with nonobstructive azoospermia did not detect any mutations. </p><p>By whole-exome sequencing in a 31-year-old Chinese man with infertility due to azoospermia and his 29-year-old sister with POF, Zhang et al. (2019) identified homozygosity for the L14P mutation in the XRCC2 gene, for which their unaffected first-cousin parents were heterozygous. </p>
</span>
<div>
<br />
</div>
</div>
<div>
<h4>
<span class="mim-font">
<strong>REFERENCES</strong>
</span>
</h4>
<div>
<p />
</div>
<div>
<ol>
<li>
<p class="mim-text-font">
Yang, Y., Guo, J., Dai, L., Zhu, Y., Hu, H., Tan, L., Chen, W., Liang, D., He, J., Tu, M., Wang, K., Wu, L.
<strong>XRCC2 mutation causes meiotic arrest, azoospermia and infertility.</strong>
J. Med. Genet. 55: 628-636, 2018.
[PubMed: 30042186]
[Full Text: https://doi.org/10.1136/jmedgenet-2017-105145]
</p>
</li>
<li>
<p class="mim-text-font">
Zhang, Y.-X., Li, H.-Y., He, W.-B., Tu, C., Du, J., Li, W., Lu, G.-X., Lin, G., Yang, Y., Tan, Y.-Q.
<strong>XRCC2 mutation causes premature ovarian insufficiency as well as non-obstructive azoospermia in humans.</strong>
Clin. Genet. 95: 442-443, 2019.
[PubMed: 30489636]
[Full Text: https://doi.org/10.1111/cge.13475]
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Creation Date:
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Marla J. F. O&#x27;Neill : 12/30/2020
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carol : 03/03/2021<br>alopez : 02/08/2021<br>alopez : 12/30/2020
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