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Entry
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- #613659 - GASTRIC CANCER
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- OMIM
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<p>
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<span class="h4">#613659</span>
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<br />
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<strong>Table of Contents</strong>
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<a href="#title"><strong>Title</strong></a>
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<a href="#phenotypeMap"><strong>Phenotype-Gene Relationships</strong></a>
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<a href="#text"><strong>Text</strong></a>
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<a href="#description">Description</a>
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<a href="#clinicalFeatures">Clinical Features</a>
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<a href="#inheritance">Inheritance</a>
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<a href="#populationGenetics">Population Genetics</a>
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<a href="#pathogenesis">Pathogenesis</a>
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<a href="#mapping">Mapping</a>
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<a href="#molecularGenetics">Molecular Genetics</a>
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<a href="#seeAlso"><strong>See Also</strong></a>
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<li role="presentation">
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<a href="#references"><strong>References</strong></a>
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<a href="#creationDate"><strong>Creation Date</strong></a>
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<a href="#editHistory"><strong>Edit History</strong></a>
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<div style="display: table-cell;">External Links</div>
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</a>
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</h4>
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<div style="display: table-row">
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<div id="mimClinicalResourcesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">▼</div>
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<div style="display: table-cell;">Clinical Resources</div>
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<div><a href="https://clinicaltrials.gov/search?cond=(GASTRIC CANCER) OR (KLF6 OR PIK3CA OR IL1RN OR ERBB2 OR MUTYH OR IL1B OR FGFR2 OR CASP10 OR KRAS OR IRF1 OR APC)" class="mim-tip-hint" title="Clinical Trials" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Clinical Trials', 'domain': 'clinicaltrials.gov'})">Clinical Trials</a></div>
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<div><a href="https://www.diseaseinfosearch.org/x/8973" class="mim-tip-hint" title="Network of disease-specific advocacy organizations, universities, private companies, government agencies, and public policy organizations." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Genetic Alliance', 'domain': 'diseaseinfosearch.org'})">Genetic Alliance</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=613659[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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<div id="mimAnimalModelsLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Animal Models</div>
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</a>
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.alliancegenome.org/disease/DOID:10534" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
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<div><a href="http://www.informatics.jax.org/disease/613659" class="mim-tip-hint" title="Phenotypes, alleles, and disease models from Mouse Genome Informatics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Phenotype', 'domain': 'informatics.jax.org'})">MGI Mouse Phenotype</a></div>
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<div><a href="https://wormbase.org/resources/disease/DOID:10534" class="mim-tip-hint" title="Database of the biology and genome of Caenorhabditis elegans and related nematodes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Disease Ontology', 'domain': 'wormbase.org'})">Wormbase Disease Ontology</a></div>
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<span>
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<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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</span>
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</span>
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</div>
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<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
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<div>
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<a id="title" class="mim-anchor"></a>
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<div>
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<a id="number" class="mim-anchor"></a>
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<div class="text-right">
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<a href="#" class="mim-tip-icd" qtip_title="<strong>ICD+</strong>" qtip_text="
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<strong>SNOMEDCT:</strong> 363349007<br />
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<strong>ICD10CM:</strong> C16, C16.9<br />
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<strong>ICD9CM:</strong> 151, 151.9<br />
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<strong>DO:</strong> 10534<br />
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">ICD+</a>
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</div>
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<div>
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<span class="h3">
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<span class="mim-font mim-tip-hint" title="Phenotype description, molecular basis known">
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<span class="text-danger"><strong>#</strong></span>
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613659
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</span>
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</span>
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</div>
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</div>
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<div>
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<a id="preferredTitle" class="mim-anchor"></a>
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<h3>
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<span class="mim-font">
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GASTRIC CANCER
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</span>
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</h3>
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</div>
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<div>
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<br />
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<a id="includedTitles" class="mim-anchor"></a>
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<div>
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<p>
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<span class="mim-font">
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Other entities represented in this entry:
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</span>
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</p>
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</div>
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<div>
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<span class="h3 mim-font">
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GASTRIC CANCER, INTESTINAL, INCLUDED
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</span>
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</div>
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</div>
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<div>
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<br />
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</div>
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</div>
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<div>
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<a id="phenotypeMap" class="mim-anchor"></a>
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<h4>
|
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<span class="mim-font">
|
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<strong>Phenotype-Gene Relationships</strong>
|
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</span>
|
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</h4>
|
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<div>
|
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<table class="table table-bordered table-condensed table-hover small mim-table-padding">
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<thead>
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<tr class="active">
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<th>
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Location
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</th>
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<th>
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Phenotype
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</th>
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<th>
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Phenotype <br /> MIM number
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</th>
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<th>
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Inheritance
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</th>
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<th>
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Phenotype <br /> mapping key
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</th>
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<th>
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Gene/Locus
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</th>
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<th>
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Gene/Locus <br /> MIM number
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</th>
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</tr>
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</thead>
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<tbody>
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<tr>
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<td>
|
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<span class="mim-font">
|
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<a href="/geneMap/1/554?start=-3&limit=10&highlight=554">
|
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1p34.1
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</a>
|
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</span>
|
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</td>
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<td>
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<span class="mim-font">
|
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Gastric cancer, somatic
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</span>
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</td>
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<td>
|
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<span class="mim-font">
|
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<a href="/entry/613659"> 613659 </a>
|
|
</span>
|
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</td>
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<td>
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<span class="mim-font">
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
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MUTYH
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</span>
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</td>
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<td>
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<span class="mim-font">
|
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<a href="/entry/604933"> 604933 </a>
|
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</span>
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</td>
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</tr>
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<tr>
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<td>
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<span class="mim-font">
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<a href="/geneMap/2/577?start=-3&limit=10&highlight=577">
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2q14.1
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</a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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{Gastric cancer risk after H. pylori infection}
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
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IL1B
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</span>
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</td>
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<td>
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<span class="mim-font">
|
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<a href="/entry/147720"> 147720 </a>
|
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</span>
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2q14.1
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<span class="mim-font">
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{Gastric cancer risk after H. pylori infection}
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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<span class="mim-font">
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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IL1RN
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<span class="mim-font">
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<a href="/entry/147679"> 147679 </a>
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<a href="/geneMap/2/913?start=-3&limit=10&highlight=913">
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2q33.1
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<span class="mim-font">
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Gastric cancer, somatic
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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CASP10
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<span class="mim-font">
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<a href="/entry/601762"> 601762 </a>
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<a href="/geneMap/3/876?start=-3&limit=10&highlight=876">
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3q26.32
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<span class="mim-font">
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Gastric cancer, somatic
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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<span class="mim-font">
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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PIK3CA
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<span class="mim-font">
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<a href="/entry/171834"> 171834 </a>
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</span>
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<span class="mim-font">
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<a href="/geneMap/5/369?start=-3&limit=10&highlight=369">
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5q22.2
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</a>
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<td>
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<span class="mim-font">
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Gastric cancer, somatic
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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APC
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<span class="mim-font">
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<a href="/entry/611731"> 611731 </a>
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<span class="mim-font">
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<a href="/geneMap/5/449?start=-3&limit=10&highlight=449">
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5q31.1
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</span>
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<td>
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<span class="mim-font">
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Gastric cancer, somatic
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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IRF1
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<span class="mim-font">
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<a href="/entry/147575"> 147575 </a>
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</span>
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<span class="mim-font">
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<a href="/geneMap/10/17?start=-3&limit=10&highlight=17">
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10p15.2
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</a>
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</span>
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</td>
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<span class="mim-font">
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Gastric cancer, somatic
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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KLF6
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<span class="mim-font">
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<a href="/entry/602053"> 602053 </a>
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</span>
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<span class="mim-font">
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<a href="/geneMap/10/618?start=-3&limit=10&highlight=618">
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10q26.13
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</td>
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<td>
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<span class="mim-font">
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Gastric cancer, somatic
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</span>
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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</span>
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</td>
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<span class="mim-font">
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<span class="mim-font">
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FGFR2
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<span class="mim-font">
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<a href="/entry/176943"> 176943 </a>
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</span>
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</td>
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<span class="mim-font">
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<a href="/geneMap/12/240?start=-3&limit=10&highlight=240">
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12p12.1
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</a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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Gastric cancer, somatic
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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<span class="mim-font">
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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KRAS
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<span class="mim-font">
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<a href="/entry/190070"> 190070 </a>
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<a href="/geneMap/17/491?start=-3&limit=10&highlight=491">
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17q12
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</td>
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<td>
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<span class="mim-font">
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Gastric cancer, somatic
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/613659"> 613659 </a>
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</span>
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</td>
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<span class="mim-font">
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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<span class="mim-font">
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ERBB2
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<span class="mim-font">
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<a href="/entry/164870"> 164870 </a>
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</span>
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</td>
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</tbody>
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</table>
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<div class="btn-group">
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<button type="button" class="btn btn-success dropdown-toggle" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
|
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PheneGene Graphics <span class="caret"></span>
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</button>
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<ul class="dropdown-menu" style="width: 17em;">
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<li><a href="/graph/linear/613659" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Linear'})"> Linear </a></li>
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<li><a href="/graph/radial/613659" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Radial'})"> Radial </a></li>
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</ul>
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</div>
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<span class="glyphicon glyphicon-question-sign mim-tip-hint" title="OMIM PheneGene graphics depict relationships between phenotypes, groups of related phenotypes (Phenotypic Series), and genes.<br /><a href='/static/omim/pdf/OMIM_Graphics.pdf' target='_blank'>A quick reference overview and guide (PDF)</a>"></span>
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<a id="text" class="mim-anchor"></a>
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<span class="mim-tip-floating" qtip_title="<strong>Looking For More References?</strong>" qtip_text="Click the 'reference plus' icon <span class='glyphicon glyphicon-plus-sign'></span> at the end of each OMIM text paragraph to see more references related to the content of the preceding paragraph.">
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<strong>TEXT</strong>
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<p>A number sign (#) is used with this entry because somatic mutations in various genes have been identified in gastric cancer tumor tissue. These genes include APC (<a href="/entry/611731">611731</a>), IRF1 (<a href="/entry/147575">147575</a>), KLF6 (<a href="/entry/602053">602053</a>), MUTYH (<a href="/entry/604933">604933</a>), KRAS (<a href="/entry/190070">190070</a>), CASP10 (<a href="/entry/601762">601762</a>), PIK3CA (<a href="/entry/171834">171834</a>), ERBB2 (<a href="/entry/164870">164870</a>), and FGFR2 (<a href="/entry/176943">176943</a>).</p>
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<div>
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<a id="description" class="mim-anchor"></a>
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<h4 href="#mimDescriptionFold" id="mimDescriptionToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
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<span id="mimDescriptionToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<span class="mim-font">
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<strong>Description</strong>
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<p>In a review article on the genetic predisposition to gastric cancer, <a href="#3" class="mim-tip-reference" title="Bevan, S., Houlston, R. S. <strong>Genetic predisposition to gastric cancer.</strong> Quart. J. Med. 92: 5-10, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10209666/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10209666</a>] [<a href="https://doi.org/10.1093/qjmed/92.1.5" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10209666">Bevan and Houlston (1999)</a> concluded that several genes may be associated with an increased risk of gastric cancer. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10209666" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see <a href="/entry/120435">120435</a>), familial adenomatous polyposis (FAP; <a href="/entry/175100">175100</a>), Peutz-Jeghers syndrome (PJS; <a href="/entry/175200">175200</a>), Cowden disease (CD; <a href="/entry/158350">158350</a>), the Li-Fraumeni syndrome (<a href="/entry/151623">151623</a>), and diffuse gastric and lobular breast cancer syndrome (DGLBC; <a href="/entry/137215">137215</a>).</p><p><a href="#5" class="mim-tip-reference" title="Canedo, P., Figueiredo, C., Machado, J. C. <strong>After Helicobacter pylori, genetic susceptibility to gastric carcinoma revisited.</strong> Helicobacter 12 Suppl. 2: 45-49, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17991176/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17991176</a>] [<a href="https://doi.org/10.1111/j.1523-5378.2007.00564.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17991176">Canedo et al. (2007)</a> provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see <a href="/entry/600263">600263</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17991176" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<br />
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<strong>Clinical Features</strong>
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<p><a href="#32" class="mim-tip-reference" title="Scott, N., Lansdown, M., Diament, R., Rathbone, B., Murday, V., Wyatt, J. I., McMahon, M., Dixon, M. F., Quirke, P. <strong>Helicobacter gastritis and intestinal metaplasia in a gastric cancer family. (Letter)</strong> Lancet 335: 728 only, 1990.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1969086/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1969086</a>] [<a href="https://doi.org/10.1016/0140-6736(90)90845-v" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1969086">Scott et al. (1990)</a> described a family in which 2 of 4 sibs under the age of 40 years presented with gastric cancer. A third sib had antrectomy for gastric dysplasia, and a fourth, aged 36, had extensive chronic atrophic gastritis and intestinal metaplasia. Of 8 children of these 4 individuals, 5 had Helicobacter pylori-positive, chronic atrophic gastritis, and in 3 of the 5, intestinal metaplasia developed in the gastric antrum but not in the body. <a href="#32" class="mim-tip-reference" title="Scott, N., Lansdown, M., Diament, R., Rathbone, B., Murday, V., Wyatt, J. I., McMahon, M., Dixon, M. F., Quirke, P. <strong>Helicobacter gastritis and intestinal metaplasia in a gastric cancer family. (Letter)</strong> Lancet 335: 728 only, 1990.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1969086/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1969086</a>] [<a href="https://doi.org/10.1016/0140-6736(90)90845-v" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1969086">Scott et al. (1990)</a> postulated that the family was segregating a genetic predisposition to the metaplasia/dysplasia/carcinoma sequence described by <a href="#8" class="mim-tip-reference" title="Correa, P. <strong>A human model of gastric carcinogenesis.</strong> Cancer Res. 48: 3554-3560, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3288329/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3288329</a>]" pmid="3288329">Correa (1988)</a>. Helicobacter pylori, previously designated Campylobacter pylori, may have acted as a promoter in the progression from normal to metaplastic epithelium, possibly by inducing a hyperproliferative state in the inflamed gastric mucosa. <a href="#32" class="mim-tip-reference" title="Scott, N., Lansdown, M., Diament, R., Rathbone, B., Murday, V., Wyatt, J. I., McMahon, M., Dixon, M. F., Quirke, P. <strong>Helicobacter gastritis and intestinal metaplasia in a gastric cancer family. (Letter)</strong> Lancet 335: 728 only, 1990.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1969086/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1969086</a>] [<a href="https://doi.org/10.1016/0140-6736(90)90845-v" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1969086">Scott et al. (1990)</a> noted that the gastric tumors in this family were consistent with the intestinal type, rather than the diffuse type. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=3288329+1969086" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#18" class="mim-tip-reference" title="Kakiuchi, H., Itoh, F., Kusano, M., Adachi, Y., Mita, H., Mihara, M., Matsuno, K., Endo, T., Hinoda, Y., Hosokawa, M., Imai, K. <strong>Familial gastric cancer in the Japanese population is frequently located at the cardiac region.</strong> Tumour Biol. 20: 235-241, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10436415/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10436415</a>] [<a href="https://doi.org/10.1159/000030069" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10436415">Kakiuchi et al. (1999)</a> studied the clinical features of the probands of 16 Japanese families with gastric cancer, defined as the existence of 3 or more family members with gastric cancer in at least 2 successive generations. Seven patients (44%) developed cancer in the cardiac region of the stomach, which was significantly higher than for gastric cancer in the general population in Japan (15.4%). The cancers were more often of the undifferentiated type (69%), and showed an increased frequency of disseminated peritoneal (40%) and liver metastases (20%) compared to gastric cancer in the general Japanese population. These unique characteristics suggested a genetic background in their etiology. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10436415" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#36" class="mim-tip-reference" title="Zanghieri, G., Di Gregorio, C., Sacchetti, C., Fante, R., Sassatelli, R., Cannizzo, G., Carriero, A., Ponz de Leon, M. <strong>Familial occurrence of gastric cancer in the 2-year experience of a population-based registry.</strong> Cancer 66: 2047-2051, 1990.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2224804/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2224804</a>] [<a href="https://doi.org/10.1002/1097-0142(19901101)66:9<2047::aid-cncr2820660934>3.0.co;2-g" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="2224804">Zanghieri et al. (1990)</a> and <a href="#23" class="mim-tip-reference" title="La Vecchia, C., Negri, E., Franceschi, S., Gentile, A. <strong>Family history and the risk of stomach and colorectal cancer.</strong> Cancer 70: 50-55, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1606546/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1606546</a>] [<a href="https://doi.org/10.1002/1097-0142(19920701)70:1<50::aid-cncr2820700109>3.0.co;2-i" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1606546">La Vecchia et al. (1992)</a> found that about 10% of gastric cancer cases show familial clustering. Epidemiologic studies have shown that the risk of gastric cancer in first-degree relatives is increased 2- to 3-fold (<a href="#10" class="mim-tip-reference" title="Goldgar, D. E., Easton, D. F., Cannon-Albright, L. A., Skolnick, M. H. <strong>Systematic population-based assessment of cancer risk in first-degree relatives of cancer probands.</strong> J. Nat. Cancer Inst. 86: 1600-1608, 1994.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7932824/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7932824</a>] [<a href="https://doi.org/10.1093/jnci/86.21.1600" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7932824">Goldgar et al., 1994</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?term=1606546+7932824+2224804" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a review, <a href="#11" class="mim-tip-reference" title="Gonzalez, C. A., Sala, N., Capella, G. <strong>Genetic susceptibility and gastric cancer risk.</strong> Int. J. Cancer 100: 249-260, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12115538/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12115538</a>] [<a href="https://doi.org/10.1002/ijc.10466" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12115538">Gonzalez et al. (2002)</a> noted that human gastric carcinogenesis best fits a multifactorial model, according to which different dietary and nondietary factors, including genetic susceptibility, are involved at different stages in the cancer process. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12115538" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>Despite a declining incidence (<a href="#15" class="mim-tip-reference" title="Howson, C. P., Hiyama, T., Wynder, E. L. <strong>The decline in gastric cancer: epidemiology of an unplanned triumph.</strong> Epidemiol. Rev. 8: 1-27, 1986.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3533579/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3533579</a>] [<a href="https://doi.org/10.1093/oxfordjournals.epirev.a036288" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3533579">Howson et al., 1986</a>), gastric cancer is a major cause of cancer death worldwide. <a href="#11" class="mim-tip-reference" title="Gonzalez, C. A., Sala, N., Capella, G. <strong>Genetic susceptibility and gastric cancer risk.</strong> Int. J. Cancer 100: 249-260, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12115538/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12115538</a>] [<a href="https://doi.org/10.1002/ijc.10466" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12115538">Gonzalez et al. (2002)</a> observed that gastric cancer constitutes the second most frequent cancer in the world and the fourth in Europe. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=3533579+12115538" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a nationwide epidemiologic study in Sweden, <a href="#12" class="mim-tip-reference" title="Hemminki, K., Jiang, Y. <strong>Familial and second gastric carcinomas: a nationwide epidemiologic study from Sweden.</strong> Cancer 94: 1157-1165, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11920487/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11920487</a>]" pmid="11920487">Hemminki and Jiang (2002)</a> found that the population-attributable proportion of familial gastric carcinoma was much lower than that cited in the literature. Patterns of multiple carcinomas suggested that immunologic factors modulate susceptibility to gastric carcinoma. The authors concluded that environmental factors, perhaps H. pylori infections, were the main reason for familial clustering of gastric carcinoma. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11920487" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#24" class="mim-tip-reference" title="Lauren, P. <strong>The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma: an attempt at a histo-clinical classification.</strong> Acta Path. Microbiol. Scand. 64: 31-49, 1965.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/14320675/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">14320675</a>] [<a href="https://doi.org/10.1111/apm.1965.64.1.31" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="14320675">Lauren (1965)</a> defined 2 main histologic types of gastric carcinomas, a 'diffuse' type and a so-called 'intestinal' type. Diffuse tumors, as observed in diffuse gastric and lobular breast cancer syndrome (DGLBC; <a href="/entry/137215">137215</a>), are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. This classification system was updated in 1995 to include 4 main types of gastric cancer: isolated cell and mixed types (representing the diffuse component); and glandular/intestinal and solid (representing the non-diffuse component). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=14320675" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>The association of gastric cancer with blood group A and pernicious anemia has been known for a long time. <a href="#34" class="mim-tip-reference" title="Thomsen, M., Jorgensen, F., Brandsborg, M., Gimsing, P., Nielsen, J. L., Ryder, L. P., Svejgaard, A. <strong>Association of pernicious anaemia and intrinsic factor antibody with HLA-D.</strong> Tissue Antigens 17: 97-103, 1981.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6166087/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6166087</a>] [<a href="https://doi.org/10.1111/j.1399-0039.1981.tb00672.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="6166087">Thomsen et al. (1981)</a> found that the HLA-DR5 genotype was associated with a 6-fold increase in risk of pernicious anemia (<a href="/entry/261000">261000</a>), suggesting that events leading to gastric cancer have a genetic component. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6166087" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#29" class="mim-tip-reference" title="Palli, D., Russo, A., Ottini, L., Masala, G., Saieva, C., Amorosi, A., Cama, A., D'Amico, C., Falchetti, M., Palmirotta, R., Decarli, A., Costantini R. M., Fraumeni, J. F., Jr. <strong>Red meat, family history, and increased risk of gastric cancer with microsatellite instability.</strong> Cancer Res. 61: 5415-5419, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11454685/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11454685</a>]" pmid="11454685">Palli et al. (2001)</a> evaluated the relation between dietary habits (particularly consumption of red meat) and MSI status using 126 gastric cancer cases and 561 population controls identified in a case-control study carried out in a high-incidence area around Florence, Italy. An MSI-positive phenotype was detected in 43 of 126 cases (34.1%). A risk of MSI-positive tumors was positively associated with consumption of red meat and meat sauce and negatively associated with consumption of white meat. Risk was especially high among subjects reporting both a positive family history for gastric cancer and a high consumption of red meat. The risk of MSI-negative tumors was strongly reduced by the frequent consumption of fresh fruits and vegetables. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11454685" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#11" class="mim-tip-reference" title="Gonzalez, C. A., Sala, N., Capella, G. <strong>Genetic susceptibility and gastric cancer risk.</strong> Int. J. Cancer 100: 249-260, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12115538/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12115538</a>] [<a href="https://doi.org/10.1002/ijc.10466" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12115538">Gonzalez et al. (2002)</a> stated that Helicobacter pylori infection is an established risk factor of gastric cancer, but gastric cancer occurs in only a very small proportion of people infected with the organism. Infection by H. pylori may result in gastric cancer through induced hyperproliferation of gastric cells, interference with antioxidant functions, and increased amounts of reactive oxygen species and nitric oxide, which may be responsible for oxidative DNA damage. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12115538" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#2" class="mim-tip-reference" title="Berman, D. M., Karhadkar, S. S., Maitra, A., Montes de Oca, R., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., Beachy, P. A. <strong>Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours.</strong> Nature 425: 846-851, 2003.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/14520411/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">14520411</a>] [<a href="https://doi.org/10.1038/nature01972" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="14520411">Berman et al. (2003)</a> demonstrated that a wide range of digestive tract tumors, including most of those originating in the esophagus, stomach, biliary tract, and pancreas, but not in the colon, display increased hedgehog pathway activity, which is suppressible by cyclopamine, a hedgehog pathway antagonist. Cyclopamine also suppresses cell growth in vitro and causes durable regression of xenograft tumors in vivo. Unlike tumors in Gorlin syndrome (<a href="/entry/109400">109400</a>), pathway activity and cell growth in these digestive tract tumors are driven by endogenous expression of hedgehog ligands, as indicated by the presence of Sonic hedgehog (<a href="/entry/600725">600725</a>) and Indian hedgehog (<a href="/entry/600726">600726</a>) transcripts, by the pathway- and growth-inhibitory activity of a hedgehog-neutralizing antibody, and by the dramatic growth-stimulatory activity of exogenously added hedgehog ligand. <a href="#2" class="mim-tip-reference" title="Berman, D. M., Karhadkar, S. S., Maitra, A., Montes de Oca, R., Gerstenblith, M. R., Briggs, K., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., Beachy, P. A. <strong>Widespread requirement for hedgehog ligand stimulation in growth of digestive tract tumours.</strong> Nature 425: 846-851, 2003.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/14520411/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">14520411</a>] [<a href="https://doi.org/10.1038/nature01972" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="14520411">Berman et al. (2003)</a> concluded that their results identified a group of common lethal malignancies in which hedgehog pathway activity, essential for tumor growth, is activated not by mutation but by ligand expression. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=14520411" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#14" class="mim-tip-reference" title="Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., Wang, T. C. <strong>Gastric cancer originating from bone marrow-derived cells.</strong> Science 306: 1568-1571, 2004.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15567866/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15567866</a>] [<a href="https://doi.org/10.1126/science.1099513" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15567866">Houghton et al. (2004)</a> showed that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to bone marrow-derived stem cell recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induced repopulation of the stomach with such stem cells. Subsequently, these cells progressed through metaplasia and dysplasia to intraepithelial cancer. <a href="#14" class="mim-tip-reference" title="Houghton, J., Stoicov, C., Nomura, S., Rogers, A. B., Carlson, J., Li, H., Cai, X., Fox, J. G., Goldenring, J. R., Wang, T. C. <strong>Gastric cancer originating from bone marrow-derived cells.</strong> Science 306: 1568-1571, 2004.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15567866/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15567866</a>] [<a href="https://doi.org/10.1126/science.1099513" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15567866">Houghton et al. (2004)</a> suggested that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15567866" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#6" class="mim-tip-reference" title="Chien, J., Aletti, G., Baldi, A., Catalano, V., Muretto, P., Keeney, G. L., Kalli, K. R., Staub, J., Ehrmann, M., Cliby, W. A., Lee, Y. K., Bible, K. C., Hartmann, L. C., Kaufmann, S. H., Shridhar, V. <strong>Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.</strong> J. Clin. Invest. 116: 1994-2004, 2006.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/16767218/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">16767218</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=16767218[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1172/JCI27698" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="16767218">Chien et al. (2006)</a> studied HTRA1 (PRSS11; <a href="/entry/602194">602194</a>) expression in tumors from 60 patients with epithelial ovarian cancer (<a href="/entry/167000">167000</a>) and 51 with gastric cancer and found that those with tumors expressing higher levels of HTRA1 showed a significantly higher response rate to chemotherapy than those with lower levels of HTRA1 expression. <a href="#6" class="mim-tip-reference" title="Chien, J., Aletti, G., Baldi, A., Catalano, V., Muretto, P., Keeney, G. L., Kalli, K. R., Staub, J., Ehrmann, M., Cliby, W. A., Lee, Y. K., Bible, K. C., Hartmann, L. C., Kaufmann, S. H., Shridhar, V. <strong>Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity.</strong> J. Clin. Invest. 116: 1994-2004, 2006.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/16767218/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">16767218</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=16767218[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1172/JCI27698" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="16767218">Chien et al. (2006)</a> suggested that loss of HTRA1 in ovarian and gastric cancers may contribute to in vivo chemoresistance. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=16767218" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>Loss of heterozygosity at chromosomes 1p, 5q, 7q, 11p, 13q, 17p, and 18p has been observed in a high proportion of gastric cancer tissues (<a href="#26" class="mim-tip-reference" title="Motomura, K., Nishisho, I., Takai, S., Tateishi, H., Okazaki, M., Yamamoto, M., Miki, T., Honjo, T., Mori, T. <strong>Loss of alleles at loci on chromosome 13 in human primary gastric cancers.</strong> Genomics 2: 180-184, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3410477/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3410477</a>] [<a href="https://doi.org/10.1016/0888-7543(88)90101-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3410477">Motomura et al., 1988</a>; <a href="#21" class="mim-tip-reference" title="Kim, C. J., Kim, W. H., Kim, C. W., Lee, J. B., Lee, C. K., Kim, Y. L. <strong>Detection of 17p loss in gastric carcinoma using polymerase chain reaction.</strong> Lab. Invest. 72: 232-236, 1995.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7853854/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7853854</a>]" pmid="7853854">Kim et al., 1995</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?term=3410477+7853854" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#1" class="mim-tip-reference" title="Aoki, M., Yamamura, Y., Noshiro, H., Sakai, K., Yokota, J., Kohno, T., Tokino, T., Ishida, S., Ohyama, S., Ninomiya, I., Uesaka, K., Kitajima, M., and 17 others. <strong>A full genome scan for gastric cancer. (Letter)</strong> J. Med. Genet. 42: 83-87, 2005.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15635081/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15635081</a>] [<a href="https://doi.org/10.1136/jmg.2004.021782" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15635081">Aoki et al. (2005)</a> performed a genomewide screen for gastric cancer susceptibility genes in 170 affected sib pairs from 142 Japanese families. Nonparametric linkage analysis revealed the strongest signal to be on chromosome 2q33-q35, with multipoint and 2-point lod scores of 1.74 and 1.98, respectively. Analysis of a subgroup with proximal gastric cancer increased the signal of linkage to 2q33-q35 to multipoint and 2-point lod scores of 3.61 and 2.93, respectively (p = 0.002 by simulation studies). <a href="#1" class="mim-tip-reference" title="Aoki, M., Yamamura, Y., Noshiro, H., Sakai, K., Yokota, J., Kohno, T., Tokino, T., Ishida, S., Ohyama, S., Ninomiya, I., Uesaka, K., Kitajima, M., and 17 others. <strong>A full genome scan for gastric cancer. (Letter)</strong> J. Med. Genet. 42: 83-87, 2005.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15635081/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15635081</a>] [<a href="https://doi.org/10.1136/jmg.2004.021782" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15635081">Aoki et al. (2005)</a> suggested that there is a gastric cancer susceptibility locus on chromosome 2q33-q35. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15635081" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><strong><em>Germline Mutations in Cancer Predisposition Syndromes</em></strong></p><p>
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Carriers of germline mutations in mismatch repair genes (see, e.g., MLH1, <a href="/entry/120436">120436</a>) have a 4-fold increased risk of gastric cancer in addition to the high risk of colorectal cancer (<a href="#25" class="mim-tip-reference" title="Lynch, H. T., Smyrk, T. <strong>Hereditary nonpolyposis colorectal cancer (Lynch syndrome): an updated review.</strong> Cancer 78: 1149-1167, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8826936/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8826936</a>] [<a href="https://doi.org/10.1002/(SICI)1097-0142(19960915)78:6<1149::AID-CNCR1>3.0.CO;2-5" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8826936">Lynch and Smyrk, 1996</a>; <a href="#35" class="mim-tip-reference" title="Watson, P., Lynch, H. T. <strong>Extracolonic cancer in hereditary nonpolyposis colorectal cancer.</strong> Cancer 71: 677-685, 1993.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8431847/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8431847</a>] [<a href="https://doi.org/10.1002/1097-0142(19930201)71:3<677::aid-cncr2820710305>3.0.co;2-#" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8431847">Watson and Lynch, 1993</a>). Mutations in mismatch repair genes result in microsatellite instability (MSI). Although MSI is seen in 20 to 30% of cases of gastric cancer (<a href="#31" class="mim-tip-reference" title="Renault, B., Calistri, D., Buonsanti, G., Nanni, O., Amadori, D., Ranzani, G. N. <strong>Microsatellite instability and mutations of p53 and TGF-beta RII genes in gastric cancer.</strong> Hum. Genet. 98: 601-607, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8882883/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8882883</a>] [<a href="https://doi.org/10.1007/s004390050267" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8882883">Renault et al., 1996</a>), germline or somatic mutations in these MMR genes are rarely seen in sporadic or familial non-HNPCC gastric cancer (<a href="#19" class="mim-tip-reference" title="Keller, G., Grimm, V., Vogelsang, H., Bischoff, P., Mueller, J., Siewert, J. R., Hofler, H. <strong>Analysis for microsatellite instability and mutations of the DNA mismatch repair gene hMLH1 in familial gastric cancer.</strong> Int. J. Cancer 68: 571-576, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8938136/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8938136</a>] [<a href="https://doi.org/10.1002/(SICI)1097-0215(19961127)68:5<571::AID-IJC3>3.0.CO;2-W" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8938136">Keller et al., 1996</a>). <a href="#28" class="mim-tip-reference" title="Ottini, L., Palli, D., Falchetti, M., D'Amico, C., Amorosi, A., Saieva, C., Calzolari, A., Cimoli, F., Tatarelli, C., De Marchis, L., Masala, G., Mariani-Costantini, R., Cama, A. <strong>Microsatellite instability in gastric cancer is associated with tumor location and family history in a high risk population from Tuscany.</strong> Cancer Res. 57: 4523-4529, 1997.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/9377564/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">9377564</a>]" pmid="9377564">Ottini et al. (1997)</a> showed that microsatellite instability was significantly associated with distal (antral) tumors of the stomach and a positive family history of gastric cancer. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=9377564+8938136+8882883+8826936+8431847" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#28" class="mim-tip-reference" title="Ottini, L., Palli, D., Falchetti, M., D'Amico, C., Amorosi, A., Saieva, C., Calzolari, A., Cimoli, F., Tatarelli, C., De Marchis, L., Masala, G., Mariani-Costantini, R., Cama, A. <strong>Microsatellite instability in gastric cancer is associated with tumor location and family history in a high risk population from Tuscany.</strong> Cancer Res. 57: 4523-4529, 1997.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/9377564/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">9377564</a>]" pmid="9377564">Ottini et al. (1997)</a> showed that microsatellite instability was significantly associated with distal (antral) tumors of the stomach and a positive family history of gastric cancer. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=9377564" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#11" class="mim-tip-reference" title="Gonzalez, C. A., Sala, N., Capella, G. <strong>Genetic susceptibility and gastric cancer risk.</strong> Int. J. Cancer 100: 249-260, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12115538/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12115538</a>] [<a href="https://doi.org/10.1002/ijc.10466" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12115538">Gonzalez et al. (2002)</a> reviewed published evidence on the contribution of genetic susceptibility to gastric cancer risk in humans. Most of the studies assessed the effect of genes involved in detoxifying pathways and inflammatory responses. The most consistent results were the increased gastric cancer risk associated with interleukin 1-beta (IL1B; <a href="/entry/147720">147720</a>) and N-acetyltransferase-1 (NAT1; <a href="/entry/108345">108345</a>) variants, which may account for up to 48% of attributable risk of gastric cancer. Polymorphisms at the HLA-DQ (<a href="/entry/146880">146880</a>), tumor necrosis factor (TNF; (<a href="/entry/191160">191160</a>), and CYP2E <a href="/entry/124040">124040</a>) genes may confer some protective effect against gastric cancer. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12115538" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#9" class="mim-tip-reference" title="El-Omar, E. M., Carrington, M., Chow, W.-H., McColl, K. E. L., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C.-C., Rothman, N., Lanyon, G., Martin, M., Fraumeni, J. F., Jr., Rabkin, C. S. <strong>Interleukin-1 polymorphisms associated with increased risk of gastric cancer.</strong> Nature 404: 398-402, 2000. Note: Erratum: Nature 412: 99 only, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10746728/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10746728</a>] [<a href="https://doi.org/10.1038/35006081" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10746728">El-Omar et al. (2000)</a> found that individuals carrying the IL1B -31 T polymorphism (<a href="/entry/147720#0001">147720.0001</a>) were at a higher risk of hypochlorhydria and of gastric cancer after H. pylori infection. <a href="#9" class="mim-tip-reference" title="El-Omar, E. M., Carrington, M., Chow, W.-H., McColl, K. E. L., Bream, J. H., Young, H. A., Herrera, J., Lissowska, J., Yuan, C.-C., Rothman, N., Lanyon, G., Martin, M., Fraumeni, J. F., Jr., Rabkin, C. S. <strong>Interleukin-1 polymorphisms associated with increased risk of gastric cancer.</strong> Nature 404: 398-402, 2000. Note: Erratum: Nature 412: 99 only, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10746728/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10746728</a>] [<a href="https://doi.org/10.1038/35006081" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10746728">El-Omar et al. (2000)</a> found that IL1RN*2 (<a href="/entry/147679#0001">147679.0001</a>) homozygotes were at increased risk of hypochlorhydria and gastric cancer. Risk for these disorders among IL1RN*2 heterozygotes was not significantly increased. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10746728" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#17" class="mim-tip-reference" title="Huntsman, D. G., Carneiro, F., Lewis, F. R., MacLeod, P. M., Hayashi, A., Monaghan, K. G., Maung, R., Seruca, R., Jackson, C. E., Caldas, C. <strong>Early gastric cancer in young, asymptomatic carriers of germ-line E-cadherin mutations.</strong> New Eng. J. Med. 344: 1904-1909, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11419427/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11419427</a>] [<a href="https://doi.org/10.1056/NEJM200106213442504" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11419427">Huntsman et al. (2001)</a> noted that hereditary gastric cancer predisposition syndromes and CDH1 (<a href="/entry/192090">192090</a>) germline mutations contribute very little to the overall load of new gastric cancer cases. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11419427" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a 2-stage genomewide association study of Japanese patients with gastric cancer and controls, the <a href="#33" class="mim-tip-reference" title="Study Group of Millennium Genome Project for Cancer. <strong>Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.</strong> Nature Genet. 40: 730-740, 2008.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18488030/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18488030</a>] [<a href="https://doi.org/10.1038/ng.152" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="18488030">Study Group of Millennium Genome Project for Cancer (2008)</a> identified a significant association between 2 SNPs in the PSCA gene (<a href="/entry/602470">602470</a>), <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs2976392;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs2976392</a> and <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs2294008;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs2294008</a>, and diffuse-type gastric cancer (allele-specific odds ratio = 1.62 and 1.58, respectively; p = 1.11 x 10(-9) and 6.3 x 10(-9), respectively). The SNPs were in strong linkage disequilibrium with each other; the authors noted that in functional studies, the risk allele 'T' of <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs2294008;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs2294008</a> reduced transcriptional activity of an upstream fragment of the gene, suggesting that <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs2294008;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs2294008</a> was the functional SNP. The same risk allele of <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs2294008;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs2294008</a> was also significantly associated with diffuse-type gastric cancer in Korean patients and controls (allele-specific OR = 1.90; p = 8.01 x 10(-11)). The authors concluded that polymorphism of the PSCA gene influences susceptibility to diffuse-type gastric cancer. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=18488030" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a Korean population, <a href="#22" class="mim-tip-reference" title="Kwon, J.-A., Lee, S.-Y., Ahn, E.-K., Seol, S.-Y., Kim, M. C., Kim, S. J., Kim, S. I., Chu, I.-S., Leem, S.-H. <strong>Short rare MUC6 minisatellites-5 alleles influence susceptibility to gastric carcinoma by regulating gene expression.</strong> Hum. Mutat. 31: 942-949, 2010.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/20506113/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">20506113</a>] [<a href="https://doi.org/10.1002/humu.21289" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="20506113">Kwon et al. (2010)</a> presented evidence suggesting that variation in polymorphic microsatellite repeats in the MUC6 gene (<a href="/entry/158374">158374</a>) may influence susceptibility to gastric cancer by regulating expression of the MUC6 gene. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=20506113" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><strong><em>Somatic Mutations</em></strong></p><p>
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Inactivation of the APC gene (<a href="/entry/611731">611731</a>) is seen in about 20% of early sporadic gastric cancer (<a href="#16" class="mim-tip-reference" title="Hsieh, L. L., Huang, Y. C. <strong>Loss of heterozygosity of APC/MCC gene in differentiated and undifferentiated gastric carcinomas in Taiwan.</strong> Cancer Lett. 96: 169-174, 1995.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7585453/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7585453</a>] [<a href="https://doi.org/10.1016/0304-3835(95)03925-m" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7585453">Hsieh and Huang, 1995</a>). <a href="#13" class="mim-tip-reference" title="Horii, A., Nakatsuru, S., Miyoshi, Y., Ichii, S., Nagase, H., Kato, Y., Yanagisawa, A., Nakamura, Y. <strong>The APC gene, responsible for familial adenomatous polyposis, is mutated in human gastric cancer.</strong> Cancer Res. 52: 3231-3233, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1317264/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1317264</a>]" pmid="1317264">Horii et al. (1992)</a> detected somatic mutations in the APC gene (<a href="/entry/611731#0010">611731.0010</a>; <a href="/entry/611731#0011">611731.0011</a>) in tumor tissue of 3 of 44 gastric cancers. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=7585453+1317264" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a human gastric cancer cell line, <a href="#27" class="mim-tip-reference" title="Nozawa, H., Oda, E., Tamura, G., Maesawa, C., Muto, T., Taniguchi, T., Tanaka, N. <strong>Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer.</strong> Int. J. Cancer 77: 522-527, 1998.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/9679752/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">9679752</a>] [<a href="https://doi.org/10.1002/(sici)1097-0215(19980812)77:4<522::aid-ijc8>3.0.co;2-w" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="9679752">Nozawa et al. (1998)</a> found a somatic point mutation in the IRF1 gene (<a href="/entry/147575#0001">147575.0001</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=9679752" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a set of 80 gastric cancer tissues, <a href="#7" class="mim-tip-reference" title="Cho, Y. G., Kim, C. J., Park, C. H., Yang, Y. M., Kim, S. Y., Nam, S. W., Lee, S. H., Yoo, N. J., Lee, J. Y., Park, W. S. <strong>Genetic alterations of the KLF6 gene in gastric cancer.</strong> Oncogene 24: 4588-4590, 2005.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15824733/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15824733</a>] [<a href="https://doi.org/10.1038/sj.onc.1208670" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15824733">Cho et al. (2005)</a> identified 4 somatic missense mutations in the KLF6 gene (see, e.g., <a href="/entry/602053#0006">602053.0006</a>); the mutations were absent from corresponding normal tissue. In addition, 16 (43.2%) of 37 informative cases showed allelic loss at the KLF6 locus. All of the cases with mutation and 13 of the 16 with allelic loss were of advanced intestinal-type gastric cancer with lymph node metastasis. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15824733" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In gastric cancer tissue from 2 unrelated patients who were carriers of H. pylori, <a href="#20" class="mim-tip-reference" title="Kim, C. J., Cho, Y. G., Park, C. H., Kim, S. Y., Nam, S. W., Lee, S. H., Yoo, N. J., Lee, J. Y., Park, W. S. <strong>Genetic alterations of the MYH gene in gastric cancer.</strong> Oncogene 23: 6820-6822, 2004.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15273732/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15273732</a>] [<a href="https://doi.org/10.1038/sj.onc.1207574" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15273732">Kim et al. (2004)</a> identified heterozygous somatic mutations in the MUTYH gene (<a href="/entry/604933#0006">604933.0006</a> and <a href="/entry/604933#0007">604933.0007</a>, respectively) and loss of the remaining allele. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15273732" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#30" class="mim-tip-reference" title="Park, W. S., Lee, J. H., Shin, M. S., Park, J. Y., Kim, H. S., Lee, J. H., Kim, Y. S., Lee, S. N., Xiao, W., Park, C. H., Lee, S. H., Yoo, N. J., Lee, J. Y. <strong>Inactivating mutations of the caspase-10 gene in gastric cancer.</strong> Oncogene 21: 2919-2925, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11973654/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11973654</a>] [<a href="https://doi.org/10.1038/sj.onc.1205394" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11973654">Park et al. (2002)</a> identified somatic mutations in the CASP10 gene (see, e.g., <a href="/entry/601762#0004">601762.0004</a> and <a href="/entry/601762#0006">601762.0006</a>) in 3 of 99 gastric cancers. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11973654" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<a href="#Caldas1999" class="mim-tip-reference" title="Caldas, C., Carneiro, F., Lynch, H. T., Yokota, J., Wiesner, G. L., Powell, S. M., Lewis, F. R., Huntsman, D. G., Pharoah, P. D. P., Jankowski, J. A., MacLeod, P., Vogelsang, H., and 12 others. <strong>Familial gastric cancer: overview and guidelines for management.</strong> J. Med. Genet. 36: 873-880, 1999.">Caldas et al. (1999)</a>
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[<a href="https://doi.org/10.1111/apm.1965.64.1.31" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="25" class="mim-anchor"></a>
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<a id="Lynch1996" class="mim-anchor"></a>
|
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<div class="">
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<p class="mim-text-font">
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|
Lynch, H. T., Smyrk, T.
|
|
<strong>Hereditary nonpolyposis colorectal cancer (Lynch syndrome): an updated review.</strong>
|
|
Cancer 78: 1149-1167, 1996.
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|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8826936/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8826936</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8826936" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1002/(SICI)1097-0142(19960915)78:6<1149::AID-CNCR1>3.0.CO;2-5" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="26" class="mim-anchor"></a>
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<a id="Motomura1988" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Motomura, K., Nishisho, I., Takai, S., Tateishi, H., Okazaki, M., Yamamoto, M., Miki, T., Honjo, T., Mori, T.
|
|
<strong>Loss of alleles at loci on chromosome 13 in human primary gastric cancers.</strong>
|
|
Genomics 2: 180-184, 1988.
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|
|
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|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3410477/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3410477</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3410477" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1016/0888-7543(88)90101-2" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="27" class="mim-anchor"></a>
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<a id="Nozawa1998" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
|
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Nozawa, H., Oda, E., Tamura, G., Maesawa, C., Muto, T., Taniguchi, T., Tanaka, N.
|
|
<strong>Functionally inactivating point mutation in the tumor-suppressor IRF-1 gene identified in human gastric cancer.</strong>
|
|
Int. J. Cancer 77: 522-527, 1998.
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|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/9679752/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">9679752</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=9679752" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1002/(sici)1097-0215(19980812)77:4<522::aid-ijc8>3.0.co;2-w" target="_blank">Full Text</a>]
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<li>
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<a id="28" class="mim-anchor"></a>
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<a id="Ottini1997" class="mim-anchor"></a>
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<div class="">
|
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<p class="mim-text-font">
|
|
Ottini, L., Palli, D., Falchetti, M., D'Amico, C., Amorosi, A., Saieva, C., Calzolari, A., Cimoli, F., Tatarelli, C., De Marchis, L., Masala, G., Mariani-Costantini, R., Cama, A.
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<strong>Microsatellite instability in gastric cancer is associated with tumor location and family history in a high risk population from Tuscany.</strong>
|
|
Cancer Res. 57: 4523-4529, 1997.
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|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/9377564/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">9377564</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=9377564" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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</p>
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</div>
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<li>
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<a id="29" class="mim-anchor"></a>
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<a id="Palli2001" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Palli, D., Russo, A., Ottini, L., Masala, G., Saieva, C., Amorosi, A., Cama, A., D'Amico, C., Falchetti, M., Palmirotta, R., Decarli, A., Costantini R. M., Fraumeni, J. F., Jr.
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<strong>Red meat, family history, and increased risk of gastric cancer with microsatellite instability.</strong>
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Cancer Res. 61: 5415-5419, 2001.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11454685/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11454685</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11454685" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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</p>
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<a id="30" class="mim-anchor"></a>
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<a id="Park2002" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Park, W. S., Lee, J. H., Shin, M. S., Park, J. Y., Kim, H. S., Lee, J. H., Kim, Y. S., Lee, S. N., Xiao, W., Park, C. H., Lee, S. H., Yoo, N. J., Lee, J. Y.
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<strong>Inactivating mutations of the caspase-10 gene in gastric cancer.</strong>
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Oncogene 21: 2919-2925, 2002.
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|
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11973654/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11973654</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11973654" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/sj.onc.1205394" target="_blank">Full Text</a>]
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<a id="31" class="mim-anchor"></a>
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<a id="Renault1996" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Renault, B., Calistri, D., Buonsanti, G., Nanni, O., Amadori, D., Ranzani, G. N.
|
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<strong>Microsatellite instability and mutations of p53 and TGF-beta RII genes in gastric cancer.</strong>
|
|
Hum. Genet. 98: 601-607, 1996.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8882883/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8882883</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8882883" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1007/s004390050267" target="_blank">Full Text</a>]
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<li>
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<a id="32" class="mim-anchor"></a>
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<a id="Scott1990" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Scott, N., Lansdown, M., Diament, R., Rathbone, B., Murday, V., Wyatt, J. I., McMahon, M., Dixon, M. F., Quirke, P.
|
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<strong>Helicobacter gastritis and intestinal metaplasia in a gastric cancer family. (Letter)</strong>
|
|
Lancet 335: 728 only, 1990.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1969086/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1969086</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1969086" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1016/0140-6736(90)90845-v" target="_blank">Full Text</a>]
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<li>
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<a id="33" class="mim-anchor"></a>
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<a id="{Study Group of Millennium Genome Project for Cancer}2008" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Study Group of Millennium Genome Project for Cancer.
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<strong>Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer.</strong>
|
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Nature Genet. 40: 730-740, 2008.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18488030/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18488030</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=18488030" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/ng.152" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="34" class="mim-anchor"></a>
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<a id="Thomsen1981" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Thomsen, M., Jorgensen, F., Brandsborg, M., Gimsing, P., Nielsen, J. L., Ryder, L. P., Svejgaard, A.
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<strong>Association of pernicious anaemia and intrinsic factor antibody with HLA-D.</strong>
|
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Tissue Antigens 17: 97-103, 1981.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6166087/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6166087</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6166087" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1111/j.1399-0039.1981.tb00672.x" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="35" class="mim-anchor"></a>
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<a id="Watson1993" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Watson, P., Lynch, H. T.
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<strong>Extracolonic cancer in hereditary nonpolyposis colorectal cancer.</strong>
|
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Cancer 71: 677-685, 1993.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8431847/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8431847</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8431847" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1002/1097-0142(19930201)71:3<677::aid-cncr2820710305>3.0.co;2-#" target="_blank">Full Text</a>]
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<li>
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<a id="36" class="mim-anchor"></a>
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<a id="Zanghieri1990" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Zanghieri, G., Di Gregorio, C., Sacchetti, C., Fante, R., Sassatelli, R., Cannizzo, G., Carriero, A., Ponz de Leon, M.
|
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<strong>Familial occurrence of gastric cancer in the 2-year experience of a population-based registry.</strong>
|
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Cancer 66: 2047-2051, 1990.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2224804/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2224804</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2224804" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1002/1097-0142(19901101)66:9<2047::aid-cncr2820660934>3.0.co;2-g" target="_blank">Full Text</a>]
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</ol>
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<div>
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<br />
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</div>
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<div>
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<a id="creationDate" class="mim-anchor"></a>
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<div class="row">
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<div class="col-lg-2 col-md-2 col-sm-4 col-xs-4">
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<span class="text-nowrap mim-text-font">
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Creation Date:
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</span>
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</div>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Cassandra L. Kniffin : 12/1/2010
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</span>
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<a id="editHistory" class="mim-anchor"></a>
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<div class="col-lg-2 col-md-2 col-sm-4 col-xs-4">
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<span class="text-nowrap mim-text-font">
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<a href="#mimCollapseEditHistory" role="button" data-toggle="collapse"> Edit History: </a>
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</span>
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</div>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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carol : 02/07/2022
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</span>
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</div>
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</div>
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<div class="row collapse" id="mimCollapseEditHistory">
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<div class="col-lg-offset-2 col-md-offset-2 col-sm-offset-4 col-xs-offset-4 col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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carol : 02/03/2022<br>carol : 05/17/2019<br>carol : 03/23/2011<br>carol : 3/22/2011<br>terry : 2/28/2011<br>carol : 12/22/2010<br>ckniffin : 12/3/2010
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<h3>
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<span class="mim-font">
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<strong>#</strong> 613659
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</span>
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</h3>
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</div>
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<div>
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<h3>
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<span class="mim-font">
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GASTRIC CANCER
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</span>
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</h3>
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<div>
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<br />
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<span class="mim-font">
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Other entities represented in this entry:
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</span>
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</p>
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</div>
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<div>
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<span class="h3 mim-font">
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GASTRIC CANCER, INTESTINAL, INCLUDED
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</span>
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</div>
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<div>
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<br />
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<div>
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<p>
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<span class="mim-text-font">
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<strong>SNOMEDCT:</strong> 363349007;
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<strong>ICD10CM:</strong> C16, C16.9;
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<strong>ICD9CM:</strong> 151, 151.9;
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<strong>DO:</strong> 10534;
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</span>
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</p>
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</div>
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<div>
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<br />
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Phenotype-Gene Relationships</strong>
|
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</span>
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</h4>
|
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<div>
|
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<table class="table table-bordered table-condensed small mim-table-padding">
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<thead>
|
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<tr class="active">
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<th>
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Location
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</th>
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<th>
|
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Phenotype
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</th>
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<th>
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Phenotype <br /> MIM number
|
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</th>
|
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<th>
|
|
Inheritance
|
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</th>
|
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<th>
|
|
Phenotype <br /> mapping key
|
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</th>
|
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<th>
|
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Gene/Locus
|
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</th>
|
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<th>
|
|
Gene/Locus <br /> MIM number
|
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</th>
|
|
</tr>
|
|
</thead>
|
|
<tbody>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
1p34.1
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
MUTYH
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|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
604933
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|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
2q14.1
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
{Gastric cancer risk after H. pylori infection}
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
IL1B
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
147720
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|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
2q14.1
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
{Gastric cancer risk after H. pylori infection}
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
IL1RN
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
147679
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
2q33.1
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
CASP10
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
601762
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
3q26.32
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
PIK3CA
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
171834
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
5q22.2
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
APC
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
611731
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
5q31.1
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
IRF1
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
147575
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
10p15.2
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
KLF6
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
602053
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
10q26.13
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
FGFR2
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
176943
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
12p12.1
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
KRAS
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
190070
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
<tr>
|
|
<td>
|
|
<span class="mim-font">
|
|
17q12
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
Gastric cancer, somatic
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
613659
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
3
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
ERBB2
|
|
</span>
|
|
</td>
|
|
<td>
|
|
<span class="mim-font">
|
|
164870
|
|
</span>
|
|
</td>
|
|
</tr>
|
|
|
|
</tbody>
|
|
</table>
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
|
|
|
|
<div>
|
|
|
|
<h4>
|
|
<span class="mim-font">
|
|
<strong>TEXT</strong>
|
|
</span>
|
|
</h4>
|
|
|
|
|
|
|
|
|
|
|
|
<span class="mim-text-font">
|
|
<p>A number sign (#) is used with this entry because somatic mutations in various genes have been identified in gastric cancer tumor tissue. These genes include APC (611731), IRF1 (147575), KLF6 (602053), MUTYH (604933), KRAS (190070), CASP10 (601762), PIK3CA (171834), ERBB2 (164870), and FGFR2 (176943).</p>
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
|
|
|
|
<div>
|
|
<h4>
|
|
<span class="mim-font">
|
|
<strong>Description</strong>
|
|
</span>
|
|
</h4>
|
|
</div>
|
|
|
|
|
|
|
|
<span class="mim-text-font">
|
|
<p>In a review article on the genetic predisposition to gastric cancer, Bevan and Houlston (1999) concluded that several genes may be associated with an increased risk of gastric cancer. </p><p>Gastric cancer is a manifestation of a number of inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (HNPCC1; see 120435), familial adenomatous polyposis (FAP; 175100), Peutz-Jeghers syndrome (PJS; 175200), Cowden disease (CD; 158350), the Li-Fraumeni syndrome (151623), and diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215).</p><p>Canedo et al. (2007) provided a review of genetic susceptibility to gastric cancer in patients infected with Helicobacter pylori (see 600263). </p>
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
|
|
|
|
<div>
|
|
<h4>
|
|
<span class="mim-font">
|
|
<strong>Clinical Features</strong>
|
|
</span>
|
|
</h4>
|
|
</div>
|
|
|
|
|
|
|
|
<span class="mim-text-font">
|
|
<p>Scott et al. (1990) described a family in which 2 of 4 sibs under the age of 40 years presented with gastric cancer. A third sib had antrectomy for gastric dysplasia, and a fourth, aged 36, had extensive chronic atrophic gastritis and intestinal metaplasia. Of 8 children of these 4 individuals, 5 had Helicobacter pylori-positive, chronic atrophic gastritis, and in 3 of the 5, intestinal metaplasia developed in the gastric antrum but not in the body. Scott et al. (1990) postulated that the family was segregating a genetic predisposition to the metaplasia/dysplasia/carcinoma sequence described by Correa (1988). Helicobacter pylori, previously designated Campylobacter pylori, may have acted as a promoter in the progression from normal to metaplastic epithelium, possibly by inducing a hyperproliferative state in the inflamed gastric mucosa. Scott et al. (1990) noted that the gastric tumors in this family were consistent with the intestinal type, rather than the diffuse type. </p><p>Kakiuchi et al. (1999) studied the clinical features of the probands of 16 Japanese families with gastric cancer, defined as the existence of 3 or more family members with gastric cancer in at least 2 successive generations. Seven patients (44%) developed cancer in the cardiac region of the stomach, which was significantly higher than for gastric cancer in the general population in Japan (15.4%). The cancers were more often of the undifferentiated type (69%), and showed an increased frequency of disseminated peritoneal (40%) and liver metastases (20%) compared to gastric cancer in the general Japanese population. These unique characteristics suggested a genetic background in their etiology. </p>
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
|
|
|
|
<div>
|
|
<h4>
|
|
<span class="mim-font">
|
|
<strong>Inheritance</strong>
|
|
</span>
|
|
</h4>
|
|
</div>
|
|
|
|
|
|
|
|
<span class="mim-text-font">
|
|
<p>Zanghieri et al. (1990) and La Vecchia et al. (1992) found that about 10% of gastric cancer cases show familial clustering. Epidemiologic studies have shown that the risk of gastric cancer in first-degree relatives is increased 2- to 3-fold (Goldgar et al., 1994). </p><p>In a review, Gonzalez et al. (2002) noted that human gastric carcinogenesis best fits a multifactorial model, according to which different dietary and nondietary factors, including genetic susceptibility, are involved at different stages in the cancer process. </p>
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
|
|
|
|
<div>
|
|
<h4>
|
|
<span class="mim-font">
|
|
<strong>Population Genetics</strong>
|
|
</span>
|
|
</h4>
|
|
</div>
|
|
|
|
|
|
|
|
<span class="mim-text-font">
|
|
<p>Despite a declining incidence (Howson et al., 1986), gastric cancer is a major cause of cancer death worldwide. Gonzalez et al. (2002) observed that gastric cancer constitutes the second most frequent cancer in the world and the fourth in Europe. </p><p>In a nationwide epidemiologic study in Sweden, Hemminki and Jiang (2002) found that the population-attributable proportion of familial gastric carcinoma was much lower than that cited in the literature. Patterns of multiple carcinomas suggested that immunologic factors modulate susceptibility to gastric carcinoma. The authors concluded that environmental factors, perhaps H. pylori infections, were the main reason for familial clustering of gastric carcinoma. </p>
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
|
|
|
|
<div>
|
|
<h4>
|
|
<span class="mim-font">
|
|
<strong>Pathogenesis</strong>
|
|
</span>
|
|
</h4>
|
|
</div>
|
|
|
|
|
|
|
|
<span class="mim-text-font">
|
|
<p>Lauren (1965) defined 2 main histologic types of gastric carcinomas, a 'diffuse' type and a so-called 'intestinal' type. Diffuse tumors, as observed in diffuse gastric and lobular breast cancer syndrome (DGLBC; 137215), are poorly differentiated infiltrating lesions resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. This classification system was updated in 1995 to include 4 main types of gastric cancer: isolated cell and mixed types (representing the diffuse component); and glandular/intestinal and solid (representing the non-diffuse component). </p><p>The association of gastric cancer with blood group A and pernicious anemia has been known for a long time. Thomsen et al. (1981) found that the HLA-DR5 genotype was associated with a 6-fold increase in risk of pernicious anemia (261000), suggesting that events leading to gastric cancer have a genetic component. </p><p>Palli et al. (2001) evaluated the relation between dietary habits (particularly consumption of red meat) and MSI status using 126 gastric cancer cases and 561 population controls identified in a case-control study carried out in a high-incidence area around Florence, Italy. An MSI-positive phenotype was detected in 43 of 126 cases (34.1%). A risk of MSI-positive tumors was positively associated with consumption of red meat and meat sauce and negatively associated with consumption of white meat. Risk was especially high among subjects reporting both a positive family history for gastric cancer and a high consumption of red meat. The risk of MSI-negative tumors was strongly reduced by the frequent consumption of fresh fruits and vegetables. </p><p>Gonzalez et al. (2002) stated that Helicobacter pylori infection is an established risk factor of gastric cancer, but gastric cancer occurs in only a very small proportion of people infected with the organism. Infection by H. pylori may result in gastric cancer through induced hyperproliferation of gastric cells, interference with antioxidant functions, and increased amounts of reactive oxygen species and nitric oxide, which may be responsible for oxidative DNA damage. </p><p>Berman et al. (2003) demonstrated that a wide range of digestive tract tumors, including most of those originating in the esophagus, stomach, biliary tract, and pancreas, but not in the colon, display increased hedgehog pathway activity, which is suppressible by cyclopamine, a hedgehog pathway antagonist. Cyclopamine also suppresses cell growth in vitro and causes durable regression of xenograft tumors in vivo. Unlike tumors in Gorlin syndrome (109400), pathway activity and cell growth in these digestive tract tumors are driven by endogenous expression of hedgehog ligands, as indicated by the presence of Sonic hedgehog (600725) and Indian hedgehog (600726) transcripts, by the pathway- and growth-inhibitory activity of a hedgehog-neutralizing antibody, and by the dramatic growth-stimulatory activity of exogenously added hedgehog ligand. Berman et al. (2003) concluded that their results identified a group of common lethal malignancies in which hedgehog pathway activity, essential for tumor growth, is activated not by mutation but by ligand expression. </p><p>Houghton et al. (2004) showed that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to bone marrow-derived stem cell recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induced repopulation of the stomach with such stem cells. Subsequently, these cells progressed through metaplasia and dysplasia to intraepithelial cancer. Houghton et al. (2004) suggested that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression. </p><p>Chien et al. (2006) studied HTRA1 (PRSS11; 602194) expression in tumors from 60 patients with epithelial ovarian cancer (167000) and 51 with gastric cancer and found that those with tumors expressing higher levels of HTRA1 showed a significantly higher response rate to chemotherapy than those with lower levels of HTRA1 expression. Chien et al. (2006) suggested that loss of HTRA1 in ovarian and gastric cancers may contribute to in vivo chemoresistance. </p>
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
|
|
|
|
<div>
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<h4>
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<span class="mim-font">
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<strong>Mapping</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Loss of heterozygosity at chromosomes 1p, 5q, 7q, 11p, 13q, 17p, and 18p has been observed in a high proportion of gastric cancer tissues (Motomura et al., 1988; Kim et al., 1995). </p><p>Aoki et al. (2005) performed a genomewide screen for gastric cancer susceptibility genes in 170 affected sib pairs from 142 Japanese families. Nonparametric linkage analysis revealed the strongest signal to be on chromosome 2q33-q35, with multipoint and 2-point lod scores of 1.74 and 1.98, respectively. Analysis of a subgroup with proximal gastric cancer increased the signal of linkage to 2q33-q35 to multipoint and 2-point lod scores of 3.61 and 2.93, respectively (p = 0.002 by simulation studies). Aoki et al. (2005) suggested that there is a gastric cancer susceptibility locus on chromosome 2q33-q35. </p>
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</span>
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<div>
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<br />
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Molecular Genetics</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p><strong><em>Germline Mutations in Cancer Predisposition Syndromes</em></strong></p><p>
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Carriers of germline mutations in mismatch repair genes (see, e.g., MLH1, 120436) have a 4-fold increased risk of gastric cancer in addition to the high risk of colorectal cancer (Lynch and Smyrk, 1996; Watson and Lynch, 1993). Mutations in mismatch repair genes result in microsatellite instability (MSI). Although MSI is seen in 20 to 30% of cases of gastric cancer (Renault et al., 1996), germline or somatic mutations in these MMR genes are rarely seen in sporadic or familial non-HNPCC gastric cancer (Keller et al., 1996). Ottini et al. (1997) showed that microsatellite instability was significantly associated with distal (antral) tumors of the stomach and a positive family history of gastric cancer. </p><p>Ottini et al. (1997) showed that microsatellite instability was significantly associated with distal (antral) tumors of the stomach and a positive family history of gastric cancer. </p><p>Gonzalez et al. (2002) reviewed published evidence on the contribution of genetic susceptibility to gastric cancer risk in humans. Most of the studies assessed the effect of genes involved in detoxifying pathways and inflammatory responses. The most consistent results were the increased gastric cancer risk associated with interleukin 1-beta (IL1B; 147720) and N-acetyltransferase-1 (NAT1; 108345) variants, which may account for up to 48% of attributable risk of gastric cancer. Polymorphisms at the HLA-DQ (146880), tumor necrosis factor (TNF; (191160), and CYP2E 124040) genes may confer some protective effect against gastric cancer. </p><p>El-Omar et al. (2000) found that individuals carrying the IL1B -31 T polymorphism (147720.0001) were at a higher risk of hypochlorhydria and of gastric cancer after H. pylori infection. El-Omar et al. (2000) found that IL1RN*2 (147679.0001) homozygotes were at increased risk of hypochlorhydria and gastric cancer. Risk for these disorders among IL1RN*2 heterozygotes was not significantly increased. </p><p>Huntsman et al. (2001) noted that hereditary gastric cancer predisposition syndromes and CDH1 (192090) germline mutations contribute very little to the overall load of new gastric cancer cases. </p><p>In a 2-stage genomewide association study of Japanese patients with gastric cancer and controls, the Study Group of Millennium Genome Project for Cancer (2008) identified a significant association between 2 SNPs in the PSCA gene (602470), rs2976392 and rs2294008, and diffuse-type gastric cancer (allele-specific odds ratio = 1.62 and 1.58, respectively; p = 1.11 x 10(-9) and 6.3 x 10(-9), respectively). The SNPs were in strong linkage disequilibrium with each other; the authors noted that in functional studies, the risk allele 'T' of rs2294008 reduced transcriptional activity of an upstream fragment of the gene, suggesting that rs2294008 was the functional SNP. The same risk allele of rs2294008 was also significantly associated with diffuse-type gastric cancer in Korean patients and controls (allele-specific OR = 1.90; p = 8.01 x 10(-11)). The authors concluded that polymorphism of the PSCA gene influences susceptibility to diffuse-type gastric cancer. </p><p>In a Korean population, Kwon et al. (2010) presented evidence suggesting that variation in polymorphic microsatellite repeats in the MUC6 gene (158374) may influence susceptibility to gastric cancer by regulating expression of the MUC6 gene. </p><p><strong><em>Somatic Mutations</em></strong></p><p>
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Inactivation of the APC gene (611731) is seen in about 20% of early sporadic gastric cancer (Hsieh and Huang, 1995). Horii et al. (1992) detected somatic mutations in the APC gene (611731.0010; 611731.0011) in tumor tissue of 3 of 44 gastric cancers. </p><p>In a human gastric cancer cell line, Nozawa et al. (1998) found a somatic point mutation in the IRF1 gene (147575.0001). </p><p>In a set of 80 gastric cancer tissues, Cho et al. (2005) identified 4 somatic missense mutations in the KLF6 gene (see, e.g., 602053.0006); the mutations were absent from corresponding normal tissue. In addition, 16 (43.2%) of 37 informative cases showed allelic loss at the KLF6 locus. All of the cases with mutation and 13 of the 16 with allelic loss were of advanced intestinal-type gastric cancer with lymph node metastasis. </p><p>In gastric cancer tissue from 2 unrelated patients who were carriers of H. pylori, Kim et al. (2004) identified heterozygous somatic mutations in the MUTYH gene (604933.0006 and 604933.0007, respectively) and loss of the remaining allele. </p><p>Park et al. (2002) identified somatic mutations in the CASP10 gene (see, e.g., 601762.0004 and 601762.0006) in 3 of 99 gastric cancers. </p>
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</span>
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<div>
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<br />
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</div>
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>See Also:</strong>
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</span>
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</h4>
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<span class="mim-text-font">
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Caldas et al. (1999)
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</span>
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<div>
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<br />
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</div>
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>REFERENCES</strong>
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