2161 lines
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Entry
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- *605328 - KRUPPEL-LIKE FACTOR 13; KLF13
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- OMIM
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<p>
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<span class="h4">*605328</span>
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<br />
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<strong>Table of Contents</strong>
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<nav>
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<li role="presentation">
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<a href="#title"><strong>Title</strong></a>
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<a href="#text"><strong>Text</strong></a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#description">Description</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#cloning">Cloning and Expression</a>
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</li>
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<li role="presentation" style="margin-left: 1em">
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<a href="#geneFunction">Gene Function</a>
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<a href="#mapping">Mapping</a>
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<a href="#references"><strong>References</strong></a>
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<a href="#contributors"><strong>Contributors</strong></a>
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<a href="#creationDate"><strong>Creation Date</strong></a>
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<li role="presentation">
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<a href="#editHistory"><strong>Edit History</strong></a>
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<h4 class="panel-title">
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<div id="mimExternalLinksToggleTriangle" class="small" style="color: white; display: table-cell;">▼</div>
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<div style="display: table-cell;">External Links</div>
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</div>
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</a>
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</h4>
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<a href="#mimGenomeLinksFold" id="mimGenomeLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimGenomeLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Genome
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</a>
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</span>
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</span>
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</div>
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<div id="mimGenomeLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="genome">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000169926;t=ENST00000307145" class="mim-tip-hint" title="Genome databases for vertebrates and other eukaryotic species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/genome/gdv/browser/gene/?id=51621" class="mim-tip-hint" title="Detailed views of the complete genomes of selected organisms from vertebrates to protozoa." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Genome Viewer', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Genome Viewer</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=605328" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimDna">
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<span class="panel-title">
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<span class="small">
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<a href="#mimDnaLinksFold" id="mimDnaLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimDnaLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> DNA
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</a>
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</span>
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</span>
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</div>
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<div id="mimDnaLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Transcript/Sequence_cDNA?db=core;g=ENSG00000169926;t=ENST00000307145" class="mim-tip-hint" title="Transcript-based views for coding and noncoding DNA." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl (MANE Select)</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_001302461,NM_015995" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_015995" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq (MANE)', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq (MANE Select)</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=605328" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimProtein">
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<span class="panel-title">
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<span class="small">
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<a href="#mimProteinLinksFold" id="mimProteinLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
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<span id="mimProteinLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Protein
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</a>
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</span>
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</span>
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</div>
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<div id="mimProteinLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://hprd.org/summary?hprd_id=05620&isoform_id=05620_1&isoform_name=Isoform_1" class="mim-tip-hint" title="The Human Protein Reference Database; manually extracted and visually depicted information on human proteins." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HPRD', 'domain': 'hprd.org'})">HPRD</a></div>
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<div><a href="https://www.proteinatlas.org/search/KLF13" class="mim-tip-hint" title="The Human Protein Atlas contains information for a large majority of all human protein-coding genes regarding the expression and localization of the corresponding proteins based on both RNA and protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HumanProteinAtlas', 'domain': 'proteinatlas.org'})">Human Protein Atlas</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/protein/4633816,4929495,14714602,15215311,15530301,17369913,37693995,119581669,608785359,608785636,698320875" class="mim-tip-hint" title="NCBI protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Protein', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Protein</a></div>
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<div><a href="https://www.uniprot.org/uniprotkb/Q9Y2Y9" class="mim-tip-hint" title="Comprehensive protein sequence and functional information, including supporting data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UniProt', 'domain': 'uniprot.org'})">UniProt</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimGeneInfo">
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<span class="panel-title">
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<span class="small">
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<a href="#mimGeneInfoLinksFold" id="mimGeneInfoLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimGeneInfoLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Gene Info</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimGeneInfoLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="http://biogps.org/#goto=genereport&id=51621" class="mim-tip-hint" title="The Gene Portal Hub; customizable portal of gene and protein function information." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'BioGPS', 'domain': 'biogps.org'})">BioGPS</a></div>
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<div><a href="https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000169926;t=ENST00000307145" class="mim-tip-hint" title="Orthologs, paralogs, regulatory regions, and splice variants." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=KLF13" class="mim-tip-hint" title="The Human Genome Compendium; web-based cards integrating automatically mined information on human genes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneCards', 'domain': 'genecards.org'})">GeneCards</a></div>
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<div><a href="http://amigo.geneontology.org/amigo/search/annotation?q=KLF13" class="mim-tip-hint" title="Terms, defined using controlled vocabulary, representing gene product properties (biologic process, cellular component, molecular function) across species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneOntology', 'domain': 'amigo.geneontology.org'})">Gene Ontology</a></div>
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<div><a href="https://www.genome.jp/dbget-bin/www_bget?hsa+51621" class="mim-tip-hint" title="Kyoto Encyclopedia of Genes and Genomes; diagrams of signaling pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'KEGG', 'domain': 'genome.jp'})">KEGG</a></div>
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<dd><a href="http://v1.marrvel.org/search/gene/KLF13" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></dd>
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<dd><a href="https://monarchinitiative.org/NCBIGene:51621" class="mim-tip-hint" title="Monarch Initiative." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Monarch', 'domain': 'monarchinitiative.org'})">Monarch</a></dd>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/51621" class="mim-tip-hint" title="Gene-specific map, sequence, expression, structure, function, citation, and homology data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Gene', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Gene</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_chrom=chr15&hgg_gene=ENST00000307145.4&hgg_start=31326835&hgg_end=31435665&hgg_type=knownGene" class="mim-tip-hint" title="UCSC Genome Bioinformatics; gene-specific structure and function information with links to other databases." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC', 'domain': 'genome.ucsc.edu'})">UCSC</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimClinicalResources">
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<span class="panel-title">
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<span class="small">
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<a href="#mimClinicalResourcesLinksFold" id="mimClinicalResourcesLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimClinicalResourcesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Clinical Resources</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimClinicalResourcesLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="clinicalResources">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://search.clinicalgenome.org/kb/genes/HGNC:13672" class="mim-tip-hint" title="A ClinGen curated resource of ratings for the strength of evidence supporting or refuting the clinical validity of the claim(s) that variation in a particular gene causes disease." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ClinGen Validity', 'domain': 'search.clinicalgenome.org'})">ClinGen Validity</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=605328[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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<span id="mimVariationLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">▼</span> Variation
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<div><a href="https://www.ncbi.nlm.nih.gov/clinvar?term=605328[MIM]" class="mim-tip-hint" title="ClinVar aggregates information about sequence variation and its relationship to human health." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ClinVar', 'domain': 'ncbi.nlm.nih.gov'})">ClinVar</a></div>
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<div><a href="https://gnomad.broadinstitute.org/gene/ENSG00000169926" class="mim-tip-hint" title="The Genome Aggregation Database (gnomAD), Broad Institute." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'gnomAD', 'domain': 'gnomad.broadinstitute.org'})">gnomAD</a></div>
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<div><a href="https://www.ebi.ac.uk/gwas/search?query=KLF13" class="mim-tip-hint" title="GWAS Catalog; NHGRI-EBI Catalog of published genome-wide association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Catalog', 'domain': 'gwascatalog.org'})">GWAS Catalog </a></div>
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<div><a href="https://www.gwascentral.org/search?q=KLF13" class="mim-tip-hint" title="GWAS Central; summary level genotype-to-phenotype information from genetic association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Central', 'domain': 'gwascentral.org'})">GWAS Central </a></div>
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<div><a href="https://evs.gs.washington.edu/EVS/PopStatsServlet?searchBy=Gene+Hugo&target=KLF13&upstreamSize=0&downstreamSize=0&x=0&y=0" class="mim-tip-hint" title="National Heart, Lung, and Blood Institute Exome Variant Server." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NHLBI EVS', 'domain': 'evs.gs.washington.edu'})">NHLBI EVS</a></div>
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<div><a href="https://www.pharmgkb.org/gene/PA30133" class="mim-tip-hint" title="Pharmacogenomics Knowledge Base; curated and annotated information regarding the effects of human genetic variations on drug response." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PharmGKB', 'domain': 'pharmgkb.org'})">PharmGKB</a></div>
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<div style="display: table-cell;">Animal Models</div>
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<div><a href="https://www.alliancegenome.org/gene/HGNC:13672" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
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<div><a href="https://flybase.org/reports/FBgn0043364.html" class="mim-tip-hint" title="A Database of Drosophila Genes and Genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'FlyBase', 'domain': 'flybase.org'})">FlyBase</a></div>
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<div><a href="https://www.mousephenotype.org/data/genes/MGI:1354948" class="mim-tip-hint" title="International Mouse Phenotyping Consortium." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'IMPC', 'domain': 'knockoutmouse.org'})">IMPC</a></div>
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<div><a href="http://v1.marrvel.org/search/gene/KLF13#HomologGenesPanel" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></div>
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<div><a href="http://www.informatics.jax.org/marker/MGI:1354948" class="mim-tip-hint" title="Mouse Genome Informatics; international database resource for the laboratory mouse, including integrated genetic, genomic, and biological data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Gene', 'domain': 'informatics.jax.org'})">MGI Mouse Gene</a></div>
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<div><a href="https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=" class="mim-tip-hint" title="Mutant Mouse Resource & Research Centers." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MMRRC', 'domain': 'mmrrc.org'})">MMRRC</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/51621/ortholog/" class="mim-tip-hint" title="Orthologous genes at NCBI." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Orthologs', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Orthologs</a></div>
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<div><a href="https://www.orthodb.org/?ncbi=51621" class="mim-tip-hint" title="Hierarchical catalogue of orthologs." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'OrthoDB', 'domain': 'orthodb.org'})">OrthoDB</a></div>
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<div><a href="https://zfin.org/ZDB-GENE-060929-1274" class="mim-tip-hint" title="The Zebrafish Model Organism Database." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ZFin', 'domain': 'zfin.org'})">ZFin</a></div>
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<div style="display: table-cell;">Cellular Pathways</div>
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<div><a href="https://reactome.org/content/query?q=KLF13&species=Homo+sapiens&types=Reaction&types=Pathway&cluster=true" class="definition" title="Protein-specific information in the context of relevant cellular pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {{'name': 'Reactome', 'domain': 'reactome.org'}})">Reactome</a></div>
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<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
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<a id="title" class="mim-anchor"></a>
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<span class="h3">
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<span class="mim-font mim-tip-hint" title="Gene description">
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<span class="text-danger"><strong>*</strong></span>
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605328
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<a id="preferredTitle" class="mim-anchor"></a>
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<h3>
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KRUPPEL-LIKE FACTOR 13; KLF13
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</div>
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<div>
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<br />
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<span class="mim-font">
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<em>Alternative titles; symbols</em>
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<h4>
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<span class="mim-font">
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RANTES FACTOR OF LATE-ACTIVATED T LYMPHOCYTES 1; RFLAT1<br />
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FKLF2
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</h4>
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<br />
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<span class="mim-text-font">
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<strong><em>HGNC Approved Gene Symbol: <a href="https://www.genenames.org/tools/search/#!/genes?query=KLF13" class="mim-tip-hint" title="HUGO Gene Nomenclature Committee." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HGNC', 'domain': 'genenames.org'})">KLF13</a></em></strong>
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<a id="cytogeneticLocation" class="mim-anchor"></a>
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<span class="mim-text-font">
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<strong>
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<em>
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Cytogenetic location: <a href="/geneMap/15/56?start=-3&limit=10&highlight=56">15q13.3</a>
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Genomic coordinates <span class="small">(GRCh38)</span> : <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&position=chr15:31326835-31435665&dgv=pack&knownGene=pack&omimGene=pack" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">15:31,326,835-31,435,665</a> </span>
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</em>
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</strong>
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<a href="https://www.ncbi.nlm.nih.gov/" target="_blank" class="small"> (from NCBI) </a>
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<h4>
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<span class="mim-font">
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<span class="mim-tip-floating" qtip_title="<strong>Looking For More References?</strong>" qtip_text="Click the 'reference plus' icon <span class='glyphicon glyphicon-plus-sign'></span> at the end of each OMIM text paragraph to see more references related to the content of the preceding paragraph.">
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<strong>TEXT</strong>
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</span>
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</span>
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<a id="description" class="mim-anchor"></a>
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<span id="mimDescriptionToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<span class="mim-font">
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<strong>Description</strong>
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<span class="mim-text-font">
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<p>KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (<a href="#2" class="mim-tip-reference" title="Scohy, S., Gabant, P., Van Reeth, T., Hertveldt, V., Dreze, P.-L., Van Vooren, P., Riviere, M., Szpirer, J., Szpiper, C. <strong>Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.</strong> Genomics 70: 93-101, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11087666/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11087666</a>] [<a href="https://doi.org/10.1006/geno.2000.6362" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11087666">Scohy et al., 2000</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11087666" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<span id="mimCloningToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<strong>Cloning and Expression</strong>
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<p>Although many genes are induced early after T-cell activation, a few, like RANTES (<a href="/entry/187011">187011</a>), are induced at the T-cell differentiation stage. The A promoter region of the RANTES gene binds REL (e.g., RELA, <a href="/entry/164014">164014</a>) as well as non-REL proteins. Using Southwestern blotting of nuclear extracts of activated peripheral blood lymphocytes (PBL) probed with oligonucleotides from the RANTES promoter A and B sites, <a href="#4" class="mim-tip-reference" title="Song, A., Chen, Y. F., Thamatrakoln, K., Storm, T. A., Krensky, A. M. <strong>RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.</strong> Immunity 10: 93-103, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10023774/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10023774</a>] [<a href="https://doi.org/10.1016/s1074-7613(00)80010-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10023774">Song et al. (1999)</a> identified proteins detected only at late activation stages. By screening a day 5 activated PBL library with a 3-tandem A site probe, <a href="#4" class="mim-tip-reference" title="Song, A., Chen, Y. F., Thamatrakoln, K., Storm, T. A., Krensky, A. M. <strong>RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.</strong> Immunity 10: 93-103, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10023774/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10023774</a>] [<a href="https://doi.org/10.1016/s1074-7613(00)80010-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10023774">Song et al. (1999)</a> obtained a cDNA encoding the KLF13 protein, which they termed RFLAT (RANTES factor of late-activated T lymphocytes). The deduced 228-amino acid protein contains 3 contiguous TFIIIA (GTF3A; <a href="/entry/600860">600860</a>)-like C-terminal DNA-binding zinc finger motifs, which are 65 to 73% homologous to SP1 (<a href="/entry/189906">189906</a>), SP3 (<a href="/entry/601804">601804</a>), and BTEB (<a href="/entry/602902">602902</a>). Its N terminus, which is preceded by a stretch rich in basic amino acids, is rich in proline, serine, and alanine residues. SDS-PAGE and Western blot analysis indicated that KLF13 is expressed as a phosphorylated 38-kD protein. Northern blot analysis revealed ubiquitous expression of 7.5- and 5.0-kb transcripts, with greatest abundance in PBL and thymus. Immunofluorescence and Western blot analysis showed that KLF13 is localized in the nucleus. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10023774" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Using degenerate PCR primers based on the sequence for KLF1 (<a href="/entry/600599">600599</a>), <a href="#1" class="mim-tip-reference" title="Asano, H., Li, X. S., Stamatoyannopoulos, G. <strong>FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes.</strong> Blood 95: 3578-3584, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10828046/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10828046</a>]" pmid="10828046">Asano et al. (2000)</a> cloned a cDNA from fetal liver erythroid cells that encodes KLF13, which they termed FKLF2 based on its structural similarity to FKLF (TIEG2; <a href="/entry/603301">603301</a>). By Northern blot analysis, they showed that KLF13 was expressed as 4.4- and 1.5-kb transcripts in the bone marrow and striated muscles but not in 12 other human tissues analyzed. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10828046" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>By searching for sequences related to the zinc finger DNA-binding domain of SP1, followed by screening a fetal mouse liver cDNA library, <a href="#2" class="mim-tip-reference" title="Scohy, S., Gabant, P., Van Reeth, T., Hertveldt, V., Dreze, P.-L., Van Vooren, P., Riviere, M., Szpirer, J., Szpiper, C. <strong>Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.</strong> Genomics 70: 93-101, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11087666/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11087666</a>] [<a href="https://doi.org/10.1006/geno.2000.6362" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11087666">Scohy et al. (2000)</a> cloned mouse Klf13. Like the human protein, mouse Klf13 encodes a deduced 288-amino acid protein. Mouse and human KLF13 share 98% amino acid identity through the zinc finger domains and 87% identity overall. Residues within each of the 3 zinc fingers that establish specific contacts with DNA are completely conserved in KLF13, suggesting that both mouse and human KLF13 recognize a classical GC box. Klf13 also contains an N-terminal region rich in proline and alanine. RT-PCR analysis revealed Klf13 expression in all mouse tissues examined, with lowest levels in testis and liver. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11087666" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>Gelshift binding analysis by <a href="#4" class="mim-tip-reference" title="Song, A., Chen, Y. F., Thamatrakoln, K., Storm, T. A., Krensky, A. M. <strong>RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.</strong> Immunity 10: 93-103, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10023774/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10023774</a>] [<a href="https://doi.org/10.1016/s1074-7613(00)80010-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10023774">Song et al. (1999)</a> demonstrated that KLF13 binds to the A and A/B RANTES promoter binding sites, but not the B site alone, and that NFKB (<a href="/entry/164011">164011</a>) also binds to these sites. Northern and Western blot analysis demonstrated that while KLF13 mRNA is detectable at constant steady state levels in resting and activated T cells, KLF13 protein appears only late after activation. Luciferase reporter assays showed that KLF13 can transactivate the RANTES gene; whereas KLF13 is the dominant transactivator of RANTES in T-cells, RELA is the dominant transactivator in fibroblasts. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10023774" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Luciferase reporter assays by <a href="#1" class="mim-tip-reference" title="Asano, H., Li, X. S., Stamatoyannopoulos, G. <strong>FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes.</strong> Blood 95: 3578-3584, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10828046/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10828046</a>]" pmid="10828046">Asano et al. (2000)</a> showed that KLF13 activates predominantly the gamma- (HBG1; <a href="/entry/142200">142200</a>) and, to a lesser degree, the epsilon- (HBE1; <a href="/entry/142100">142100</a>) and beta- (HBB; <a href="/entry/141900">141900</a>) globin gene promoters. They found that KLF13 is involved in activation of transcription of a wide variety of genes in the cells of erythroid lineage, including GATA1 (<a href="/entry/305371">305371</a>), glycophorin B (<a href="/entry/617923">617923</a>), ferrochelatase (<a href="/entry/612386">612386</a>), porphobilinogen deaminase (HMBS; <a href="/entry/609806">609806</a>), and 5-aminolevulinate synthase (<a href="/entry/125290">125290</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10828046" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#3" class="mim-tip-reference" title="Scott, A. F. <strong>Personal Communication.</strong> Baltimore, Md. 9/25/2000."None>Scott (2000)</a> mapped the KLF13 gene to chromosome 15 based on sequence similarity between the KLF13 sequence (GenBank <a href="https://www.ncbi.nlm.nih.gov/search/all/?term=AF150628" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'GENBANK\', \'domain\': \'ncbi.nlm.nih.gov\'})">AF150628</a>) and a chromosome 15 clone (GenBank <a href="https://www.ncbi.nlm.nih.gov/search/all/?term=AC009873" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'GENBANK\', \'domain\': \'ncbi.nlm.nih.gov\'})">AC009873</a>). By somatic cell hybrid analysis, <a href="#2" class="mim-tip-reference" title="Scohy, S., Gabant, P., Van Reeth, T., Hertveldt, V., Dreze, P.-L., Van Vooren, P., Riviere, M., Szpirer, J., Szpiper, C. <strong>Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.</strong> Genomics 70: 93-101, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11087666/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11087666</a>] [<a href="https://doi.org/10.1006/geno.2000.6362" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11087666">Scohy et al. (2000)</a> mapped the KLF13 gene to chromosome 15. <a href="#5" class="mim-tip-reference" title="Suske, G., Bruford, E., Philipsen, S. <strong>Mammalian SP/KLF transcription factors: bring in the family.</strong> Genomics 85: 551-556, 2005.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15820306/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15820306</a>] [<a href="https://doi.org/10.1016/j.ygeno.2005.01.005" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15820306">Suske et al. (2005)</a> stated that the human KLF13 gene maps to chromosome 15q13.2, and the mouse Klf13 gene to chromosome 7C. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=15820306+11087666" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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Asano, H., Li, X. S., Stamatoyannopoulos, G.
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<strong>FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes.</strong>
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Blood 95: 3578-3584, 2000.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10828046/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10828046</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10828046" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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Scohy, S., Gabant, P., Van Reeth, T., Hertveldt, V., Dreze, P.-L., Van Vooren, P., Riviere, M., Szpirer, J., Szpiper, C.
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<strong>Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.</strong>
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Genomics 70: 93-101, 2000.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11087666/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11087666</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11087666" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1006/geno.2000.6362" target="_blank">Full Text</a>]
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Scott, A. F.
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<strong>Personal Communication.</strong>
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Baltimore, Md. 9/25/2000.
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Song, A., Chen, Y. F., Thamatrakoln, K., Storm, T. A., Krensky, A. M.
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<strong>RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.</strong>
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Immunity 10: 93-103, 1999.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10023774/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10023774</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10023774" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1016/s1074-7613(00)80010-2" target="_blank">Full Text</a>]
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Suske, G., Bruford, E., Philipsen, S.
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Genomics 85: 551-556, 2005.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15820306/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15820306</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15820306" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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Patricia A. Hartz - updated : 5/31/2005
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Patricia A. Hartz - updated : 4/27/2004<br>Victor A. McKusick - updated : 10/11/2000
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carol : 11/06/2008<br>ckniffin : 1/5/2006<br>wwang : 5/31/2005<br>mgross : 4/27/2004<br>carol : 10/12/2000<br>carol : 10/11/2000
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<span class="mim-text-font">
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<strong><em>HGNC Approved Gene Symbol: KLF13</em></strong>
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<strong>
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<em>
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Cytogenetic location: 15q13.3
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Genomic coordinates <span class="small">(GRCh38)</span> : 15:31,326,835-31,435,665 </span>
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</em>
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</strong>
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<span class="small">(from NCBI)</span>
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<span class="mim-font">
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<strong>TEXT</strong>
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<span class="mim-font">
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<strong>Description</strong>
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<span class="mim-text-font">
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<p>KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes (Scohy et al., 2000). </p>
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<h4>
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<span class="mim-font">
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<strong>Cloning and Expression</strong>
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</span>
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</h4>
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<span class="mim-text-font">
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<p>Although many genes are induced early after T-cell activation, a few, like RANTES (187011), are induced at the T-cell differentiation stage. The A promoter region of the RANTES gene binds REL (e.g., RELA, 164014) as well as non-REL proteins. Using Southwestern blotting of nuclear extracts of activated peripheral blood lymphocytes (PBL) probed with oligonucleotides from the RANTES promoter A and B sites, Song et al. (1999) identified proteins detected only at late activation stages. By screening a day 5 activated PBL library with a 3-tandem A site probe, Song et al. (1999) obtained a cDNA encoding the KLF13 protein, which they termed RFLAT (RANTES factor of late-activated T lymphocytes). The deduced 228-amino acid protein contains 3 contiguous TFIIIA (GTF3A; 600860)-like C-terminal DNA-binding zinc finger motifs, which are 65 to 73% homologous to SP1 (189906), SP3 (601804), and BTEB (602902). Its N terminus, which is preceded by a stretch rich in basic amino acids, is rich in proline, serine, and alanine residues. SDS-PAGE and Western blot analysis indicated that KLF13 is expressed as a phosphorylated 38-kD protein. Northern blot analysis revealed ubiquitous expression of 7.5- and 5.0-kb transcripts, with greatest abundance in PBL and thymus. Immunofluorescence and Western blot analysis showed that KLF13 is localized in the nucleus. </p><p>Using degenerate PCR primers based on the sequence for KLF1 (600599), Asano et al. (2000) cloned a cDNA from fetal liver erythroid cells that encodes KLF13, which they termed FKLF2 based on its structural similarity to FKLF (TIEG2; 603301). By Northern blot analysis, they showed that KLF13 was expressed as 4.4- and 1.5-kb transcripts in the bone marrow and striated muscles but not in 12 other human tissues analyzed. </p><p>By searching for sequences related to the zinc finger DNA-binding domain of SP1, followed by screening a fetal mouse liver cDNA library, Scohy et al. (2000) cloned mouse Klf13. Like the human protein, mouse Klf13 encodes a deduced 288-amino acid protein. Mouse and human KLF13 share 98% amino acid identity through the zinc finger domains and 87% identity overall. Residues within each of the 3 zinc fingers that establish specific contacts with DNA are completely conserved in KLF13, suggesting that both mouse and human KLF13 recognize a classical GC box. Klf13 also contains an N-terminal region rich in proline and alanine. RT-PCR analysis revealed Klf13 expression in all mouse tissues examined, with lowest levels in testis and liver. </p>
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</span>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Gene Function</strong>
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</span>
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</h4>
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<span class="mim-text-font">
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<p>Gelshift binding analysis by Song et al. (1999) demonstrated that KLF13 binds to the A and A/B RANTES promoter binding sites, but not the B site alone, and that NFKB (164011) also binds to these sites. Northern and Western blot analysis demonstrated that while KLF13 mRNA is detectable at constant steady state levels in resting and activated T cells, KLF13 protein appears only late after activation. Luciferase reporter assays showed that KLF13 can transactivate the RANTES gene; whereas KLF13 is the dominant transactivator of RANTES in T-cells, RELA is the dominant transactivator in fibroblasts. </p><p>Luciferase reporter assays by Asano et al. (2000) showed that KLF13 activates predominantly the gamma- (HBG1; 142200) and, to a lesser degree, the epsilon- (HBE1; 142100) and beta- (HBB; 141900) globin gene promoters. They found that KLF13 is involved in activation of transcription of a wide variety of genes in the cells of erythroid lineage, including GATA1 (305371), glycophorin B (617923), ferrochelatase (612386), porphobilinogen deaminase (HMBS; 609806), and 5-aminolevulinate synthase (125290). </p>
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</span>
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<h4>
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<span class="mim-font">
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<strong>Mapping</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Scott (2000) mapped the KLF13 gene to chromosome 15 based on sequence similarity between the KLF13 sequence (GenBank AF150628) and a chromosome 15 clone (GenBank AC009873). By somatic cell hybrid analysis, Scohy et al. (2000) mapped the KLF13 gene to chromosome 15. Suske et al. (2005) stated that the human KLF13 gene maps to chromosome 15q13.2, and the mouse Klf13 gene to chromosome 7C. </p>
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</span>
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<h4>
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<span class="mim-font">
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<strong>REFERENCES</strong>
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</span>
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</h4>
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<p />
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</div>
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<ol>
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<li>
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<p class="mim-text-font">
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Asano, H., Li, X. S., Stamatoyannopoulos, G.
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<strong>FKLF-2: a novel Kruppel-like transcriptional factor that activates globin and other erythroid lineage genes.</strong>
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Blood 95: 3578-3584, 2000.
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[PubMed: 10828046]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Scohy, S., Gabant, P., Van Reeth, T., Hertveldt, V., Dreze, P.-L., Van Vooren, P., Riviere, M., Szpirer, J., Szpiper, C.
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<strong>Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family.</strong>
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Genomics 70: 93-101, 2000.
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[PubMed: 11087666]
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[Full Text: https://doi.org/10.1006/geno.2000.6362]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Scott, A. F.
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<strong>Personal Communication.</strong>
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Baltimore, Md. 9/25/2000.
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Song, A., Chen, Y. F., Thamatrakoln, K., Storm, T. A., Krensky, A. M.
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<strong>RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes.</strong>
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Immunity 10: 93-103, 1999.
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[PubMed: 10023774]
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[Full Text: https://doi.org/10.1016/s1074-7613(00)80010-2]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Suske, G., Bruford, E., Philipsen, S.
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<strong>Mammalian SP/KLF transcription factors: bring in the family.</strong>
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Genomics 85: 551-556, 2005.
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[PubMed: 15820306]
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[Full Text: https://doi.org/10.1016/j.ygeno.2005.01.005]
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</p>
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</li>
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</ol>
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<div>
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<br />
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</div>
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<div class="col-lg-1 col-md-1 col-sm-2 col-xs-2">
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<span class="text-nowrap mim-text-font">
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Contributors:
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</span>
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</div>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Patricia A. Hartz - updated : 5/31/2005<br>Patricia A. Hartz - updated : 4/27/2004<br>Victor A. McKusick - updated : 10/11/2000
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</span>
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<span class="text-nowrap mim-text-font">
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Creation Date:
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</span>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Paul J. Converse : 10/11/2000
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Edit History:
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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mgross : 03/29/2018<br>carol : 11/06/2008<br>ckniffin : 1/5/2006<br>wwang : 5/31/2005<br>mgross : 4/27/2004<br>carol : 10/12/2000<br>carol : 10/11/2000
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