2256 lines
145 KiB
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- *600453 - TRIPARTITE MOTIF-CONTAINING PROTEIN 25; TRIM25
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- OMIM
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<p>
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<span class="h4">*600453</span>
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<br />
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<strong>Table of Contents</strong>
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</p>
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<li role="presentation">
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<a href="#title"><strong>Title</strong></a>
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<a href="#text"><strong>Text</strong></a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#cloning">Cloning and Expression</a>
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<a href="#mapping">Mapping</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#geneFunction">Gene Function</a>
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<a href="#animalModel">Animal Model</a>
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<a href="#references"><strong>References</strong></a>
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<a href="#contributors"><strong>Contributors</strong></a>
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<a href="#creationDate"><strong>Creation Date</strong></a>
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<li role="presentation">
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<a href="#editHistory"><strong>Edit History</strong></a>
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<h4 class="panel-title">
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<a href="#mimExternalLinksFold" id="mimExternalLinksToggle" class="mimTriangleToggle" role="button" data-toggle="collapse">
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<div id="mimExternalLinksToggleTriangle" class="small" style="color: white; display: table-cell;">▼</div>
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<div style="display: table-cell;">External Links</div>
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</div>
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</a>
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</h4>
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<a href="#mimGenomeLinksFold" id="mimGenomeLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimGenomeLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Genome
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</a>
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</span>
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</span>
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</div>
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<div id="mimGenomeLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="genome">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000121060;t=ENST00000316881" class="mim-tip-hint" title="Genome databases for vertebrates and other eukaryotic species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/genome/gdv/browser/gene/?id=7706" class="mim-tip-hint" title="Detailed views of the complete genomes of selected organisms from vertebrates to protozoa." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Genome Viewer', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Genome Viewer</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=600453" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimDna">
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<span class="panel-title">
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<span class="small">
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<a href="#mimDnaLinksFold" id="mimDnaLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimDnaLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> DNA
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</a>
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</span>
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</span>
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</div>
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<div id="mimDnaLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Transcript/Sequence_cDNA?db=core;g=ENSG00000121060;t=ENST00000316881" class="mim-tip-hint" title="Transcript-based views for coding and noncoding DNA." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl (MANE Select)</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_005082" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_005082" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq (MANE)', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq (MANE Select)</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=600453" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimProtein">
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<span class="panel-title">
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<span class="small">
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<a href="#mimProteinLinksFold" id="mimProteinLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimProteinLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Protein
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</a>
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</span>
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</span>
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</div>
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<div id="mimProteinLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://hprd.org/summary?hprd_id=02711&isoform_id=02711_1&isoform_name=Isoform_1" class="mim-tip-hint" title="The Human Protein Reference Database; manually extracted and visually depicted information on human proteins." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HPRD', 'domain': 'hprd.org'})">HPRD</a></div>
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<div><a href="https://www.proteinatlas.org/search/TRIM25" class="mim-tip-hint" title="The Human Protein Atlas contains information for a large majority of all human protein-coding genes regarding the expression and localization of the corresponding proteins based on both RNA and protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HumanProteinAtlas', 'domain': 'proteinatlas.org'})">Human Protein Atlas</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/protein/458726,16877339,27769298,62087568,68160937,119614929,119614930,119614931,313104033" class="mim-tip-hint" title="NCBI protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Protein', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Protein</a></div>
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<div><a href="https://www.uniprot.org/uniprotkb/Q14258" class="mim-tip-hint" title="Comprehensive protein sequence and functional information, including supporting data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UniProt', 'domain': 'uniprot.org'})">UniProt</a></div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimGeneInfo">
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<span class="panel-title">
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<span class="small">
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<a href="#mimGeneInfoLinksFold" id="mimGeneInfoLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimGeneInfoLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Gene Info</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimGeneInfoLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="http://biogps.org/#goto=genereport&id=7706" class="mim-tip-hint" title="The Gene Portal Hub; customizable portal of gene and protein function information." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'BioGPS', 'domain': 'biogps.org'})">BioGPS</a></div>
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<div><a href="https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000121060;t=ENST00000316881" class="mim-tip-hint" title="Orthologs, paralogs, regulatory regions, and splice variants." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=TRIM25" class="mim-tip-hint" title="The Human Genome Compendium; web-based cards integrating automatically mined information on human genes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneCards', 'domain': 'genecards.org'})">GeneCards</a></div>
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<div><a href="http://amigo.geneontology.org/amigo/search/annotation?q=TRIM25" class="mim-tip-hint" title="Terms, defined using controlled vocabulary, representing gene product properties (biologic process, cellular component, molecular function) across species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneOntology', 'domain': 'amigo.geneontology.org'})">Gene Ontology</a></div>
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<div><a href="https://www.genome.jp/dbget-bin/www_bget?hsa+7706" class="mim-tip-hint" title="Kyoto Encyclopedia of Genes and Genomes; diagrams of signaling pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'KEGG', 'domain': 'genome.jp'})">KEGG</a></div>
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<dd><a href="http://v1.marrvel.org/search/gene/TRIM25" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></dd>
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<dd><a href="https://monarchinitiative.org/NCBIGene:7706" class="mim-tip-hint" title="Monarch Initiative." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Monarch', 'domain': 'monarchinitiative.org'})">Monarch</a></dd>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/7706" class="mim-tip-hint" title="Gene-specific map, sequence, expression, structure, function, citation, and homology data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Gene', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Gene</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_chrom=chr17&hgg_gene=ENST00000316881.9&hgg_start=56887909&hgg_end=56914049&hgg_type=knownGene" class="mim-tip-hint" title="UCSC Genome Bioinformatics; gene-specific structure and function information with links to other databases." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC', 'domain': 'genome.ucsc.edu'})">UCSC</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimClinicalResources">
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<span class="panel-title">
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<span class="small">
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<a href="#mimClinicalResourcesLinksFold" id="mimClinicalResourcesLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimClinicalResourcesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Clinical Resources</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimClinicalResourcesLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="clinicalResources">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=600453[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimVariation">
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<span class="panel-title">
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<span class="small">
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<a href="#mimVariationLinksFold" id="mimVariationLinksToggle" class=" mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimVariationLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">▼</span> Variation
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</a>
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<div id="mimVariationLinksFold" class="panel-collapse collapse in mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ncbi.nlm.nih.gov/clinvar?term=600453[MIM]" class="mim-tip-hint" title="ClinVar aggregates information about sequence variation and its relationship to human health." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ClinVar', 'domain': 'ncbi.nlm.nih.gov'})">ClinVar</a></div>
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<div><a href="https://www.deciphergenomics.org/gene/TRIM25/overview/clinical-info" class="mim-tip-hint" title="DECIPHER" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'DECIPHER', 'domain': 'DECIPHER'})">DECIPHER</a></div>
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<div><a href="https://gnomad.broadinstitute.org/gene/ENSG00000121060" class="mim-tip-hint" title="The Genome Aggregation Database (gnomAD), Broad Institute." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'gnomAD', 'domain': 'gnomad.broadinstitute.org'})">gnomAD</a></div>
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<div><a href="https://www.ebi.ac.uk/gwas/search?query=TRIM25" class="mim-tip-hint" title="GWAS Catalog; NHGRI-EBI Catalog of published genome-wide association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Catalog', 'domain': 'gwascatalog.org'})">GWAS Catalog </a></div>
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<div><a href="https://www.gwascentral.org/search?q=TRIM25" class="mim-tip-hint" title="GWAS Central; summary level genotype-to-phenotype information from genetic association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Central', 'domain': 'gwascentral.org'})">GWAS Central </a></div>
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<div><a href="https://evs.gs.washington.edu/EVS/PopStatsServlet?searchBy=Gene+Hugo&target=TRIM25&upstreamSize=0&downstreamSize=0&x=0&y=0" class="mim-tip-hint" title="National Heart, Lung, and Blood Institute Exome Variant Server." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NHLBI EVS', 'domain': 'evs.gs.washington.edu'})">NHLBI EVS</a></div>
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<div><a href="https://www.pharmgkb.org/gene/PA37519" class="mim-tip-hint" title="Pharmacogenomics Knowledge Base; curated and annotated information regarding the effects of human genetic variations on drug response." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PharmGKB', 'domain': 'pharmgkb.org'})">PharmGKB</a></div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimAnimalModels">
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<span class="panel-title">
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<span class="small">
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<a href="#mimAnimalModelsLinksFold" id="mimAnimalModelsLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimAnimalModelsLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Animal Models</div>
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</div>
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</a>
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<div id="mimAnimalModelsLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.alliancegenome.org/gene/HGNC:12932" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
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<div><a href="https://www.mousephenotype.org/data/genes/MGI:102749" class="mim-tip-hint" title="International Mouse Phenotyping Consortium." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'IMPC', 'domain': 'knockoutmouse.org'})">IMPC</a></div>
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<div><a href="http://v1.marrvel.org/search/gene/TRIM25#HomologGenesPanel" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></div>
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<div><a href="http://www.informatics.jax.org/marker/MGI:102749" class="mim-tip-hint" title="Mouse Genome Informatics; international database resource for the laboratory mouse, including integrated genetic, genomic, and biological data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Gene', 'domain': 'informatics.jax.org'})">MGI Mouse Gene</a></div>
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<div><a href="https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=" class="mim-tip-hint" title="Mutant Mouse Resource & Research Centers." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MMRRC', 'domain': 'mmrrc.org'})">MMRRC</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/7706/ortholog/" class="mim-tip-hint" title="Orthologous genes at NCBI." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Orthologs', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Orthologs</a></div>
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<div><a href="https://www.orthodb.org/?ncbi=7706" class="mim-tip-hint" title="Hierarchical catalogue of orthologs." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'OrthoDB', 'domain': 'orthodb.org'})">OrthoDB</a></div>
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<div><a href="mim#WormbaseGeneFold" id="mimWormbaseGeneToggle" data-toggle="collapse" class="mim-tip-hint mimTriangleToggle" title="Database of the biology and genome of Caenorhabditis elegans and related nematodes."><span id="mimWormbaseGeneToggleTriangle" class="small" style="margin-left: -0.8em;">►</span>Wormbase Gene</div>
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<div id="mimWormbaseGeneFold" class="collapse">
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<div style="margin-left: 0.5em;"><a href="https://wormbase.org/db/gene/gene?name=WBGene00015114;class=Gene" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">WBGene00015114 </a></div><div style="margin-left: 0.5em;"><a href="https://wormbase.org/db/gene/gene?name=WBGene00016190;class=Gene" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">WBGene00016190 </a></div><div style="margin-left: 0.5em;"><a href="https://wormbase.org/db/gene/gene?name=WBGene00016191;class=Gene" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">WBGene00016191 </a></div><div style="margin-left: 0.5em;"><a href="https://wormbase.org/db/gene/gene?name=WBGene00018384;class=Gene" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">WBGene00018384 </a></div><div style="margin-left: 0.5em;"><a href="https://wormbase.org/db/gene/gene?name=WBGene00022868;class=Gene" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">WBGene00022868 </a></div><div style="margin-left: 0.5em;"><a href="https://wormbase.org/db/gene/gene?name=WBGene00022870;class=Gene" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">WBGene00022870 </a></div><div style="margin-left: 0.5em;"><a href="https://wormbase.org/db/gene/gene?name=WBGene00022872;class=Gene" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">WBGene00022872 </a></div>
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<div><a href="https://zfin.org/ZDB-GENE-040426-797" class="mim-tip-hint" title="The Zebrafish Model Organism Database." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ZFin', 'domain': 'zfin.org'})">ZFin</a></div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimCellularPathways">
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<span class="panel-title">
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<span class="small">
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<a href="#mimCellularPathwaysLinksFold" id="mimCellularPathwaysLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimCellularPathwaysLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Cellular Pathways</div>
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</div>
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</a>
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</span>
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</div>
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<div id="mimCellularPathwaysLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:7706" class="mim-tip-hint" title="Kyoto Encyclopedia of Genes and Genomes; diagrams of signaling pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'KEGG', 'domain': 'genome.jp'})">KEGG</a></div>
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<div><a href="https://reactome.org/content/query?q=TRIM25&species=Homo+sapiens&types=Reaction&types=Pathway&cluster=true" class="definition" title="Protein-specific information in the context of relevant cellular pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {{'name': 'Reactome', 'domain': 'reactome.org'}})">Reactome</a></div>
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<span>
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<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
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<div>
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<a id="title" class="mim-anchor"></a>
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<div>
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<a id="number" class="mim-anchor"></a>
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<div class="text-right">
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<div>
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<span class="h3">
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<span class="mim-font mim-tip-hint" title="Gene description">
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<span class="text-danger"><strong>*</strong></span>
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600453
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</span>
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</span>
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</div>
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</div>
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<div>
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<a id="preferredTitle" class="mim-anchor"></a>
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<h3>
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<span class="mim-font">
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TRIPARTITE MOTIF-CONTAINING PROTEIN 25; TRIM25
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</span>
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</h3>
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</div>
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<div>
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<br />
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</div>
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<div>
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<a id="alternativeTitles" class="mim-anchor"></a>
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<div>
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<p>
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<span class="mim-font">
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<em>Alternative titles; symbols</em>
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</div>
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<div>
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<h4>
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<span class="mim-font">
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ZINC FINGER PROTEIN 147; ZNF147<br />
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ESTROGEN-RESPONSIVE FINGER PROTEIN; EFP
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</span>
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</h4>
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</div>
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<div>
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<br />
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</div>
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<a id="approvedGeneSymbols" class="mim-anchor"></a>
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<p>
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<span class="mim-text-font">
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<strong><em>HGNC Approved Gene Symbol: <a href="https://www.genenames.org/tools/search/#!/genes?query=TRIM25" class="mim-tip-hint" title="HUGO Gene Nomenclature Committee." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HGNC', 'domain': 'genenames.org'})">TRIM25</a></em></strong>
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</span>
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</p>
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<div>
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<a id="cytogeneticLocation" class="mim-anchor"></a>
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<p>
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<span class="mim-text-font">
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<strong>
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<em>
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Cytogenetic location: <a href="/geneMap/17/770?start=-3&limit=10&highlight=770">17q22</a>
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Genomic coordinates <span class="small">(GRCh38)</span> : <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&position=chr17:56887909-56914049&dgv=pack&knownGene=pack&omimGene=pack" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">17:56,887,909-56,914,049</a> </span>
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</em>
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</strong>
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<a href="https://www.ncbi.nlm.nih.gov/" target="_blank" class="small"> (from NCBI) </a>
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</span>
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</p>
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<div>
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<div>
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<br />
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</div>
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<div>
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<a id="text" class="mim-anchor"></a>
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<h4>
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<span class="mim-font">
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<span class="mim-tip-floating" qtip_title="<strong>Looking For More References?</strong>" qtip_text="Click the 'reference plus' icon <span class='glyphicon glyphicon-plus-sign'></span> at the end of each OMIM text paragraph to see more references related to the content of the preceding paragraph.">
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<strong>TEXT</strong>
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</span>
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</span>
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</h4>
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<div>
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<a id="cloning" class="mim-anchor"></a>
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<h4 href="#mimCloningFold" id="mimCloningToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
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<span id="mimCloningToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<span class="mim-font">
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<strong>Cloning and Expression</strong>
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</span>
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</h4>
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<div id="mimCloningFold" class="collapse in mimTextToggleFold">
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<span class="mim-text-font">
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<p>The human estrogen-responsive finger protein, a member of the RING finger protein family, was isolated by <a href="#2" class="mim-tip-reference" title="Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H., Muramatsu, M. <strong>Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.</strong> Proc. Nat. Acad. Sci. 90: 11117-11121, 1993.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8248217/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8248217</a>] [<a href="https://doi.org/10.1073/pnas.90.23.11117" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8248217">Inoue et al. (1993)</a> from a human placenta cDNA library using an estrogen receptor-binding fragment containing an estrogen-responsive element. Since this estrogen-responsive finger protein is induced by estrogen via an estrogen-responsive element (ERE) in the 3-prime untranslated region of the gene, it is an attractive candidate for the correlation between estradiol levels and breast/ovarian cancer risk. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8248217" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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</span>
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<div>
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<br />
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<div>
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<a id="mapping" class="mim-anchor"></a>
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<h4 href="#mimMappingFold" id="mimMappingToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
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<span id="mimMappingToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<span class="mim-font">
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<strong>Mapping</strong>
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</h4>
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<p>By fluorescence in situ hybridization, <a href="#3" class="mim-tip-reference" title="Inoue, S., Orimo, A., Matsuda, Y., Inazawa, J., Emi, M., Nakamura, Y., Hori, T., Muramatsu, M. <strong>Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family.</strong> Genomics 25: 581-583, 1995.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7789997/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7789997</a>] [<a href="https://doi.org/10.1016/0888-7543(95)80064-s" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7789997">Inoue et al. (1995)</a> demonstrated that the human EFP gene, also called ZNF147, is located on 17q23.1 and that mouse Efp is located at 11C. <a href="#4" class="mim-tip-reference" title="Law, D. J., Prasad, M. A., King, S. E., Spranger, K. D., Lee, Y. H., Fox, R. E., Collins, E. E., Gebuhr, T. C., Miller, D. E., Petty, E. M. <strong>Localization of the human estrogen-responsive finger protein (EFP) gene (ZNF147) within a YAC contig containing the myeloperoxidase (MPO) gene.</strong> Genomics 28: 361-363, 1995.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8530055/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8530055</a>] [<a href="https://doi.org/10.1006/geno.1995.1160" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8530055">Law et al. (1995)</a> demonstrated that the ZNF147 gene is located within a YAC contig containing the myeloperoxidase (MPO; <a href="/entry/606989">606989</a>) gene. Approximately 300 kb separate the 2 loci. This result was confirmed by fluorescence in situ hybridization, which again showed that the EFP gene is located at 17q23.1 and refined the assignment of the location of MPO to the same site. At the same time, they mapped the homologous gene in the mouse to chromosome 11 near the Mpo gene. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=8530055+7789997" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#7" class="mim-tip-reference" title="Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S. <strong>Efp targets 14-3-3-sigma for proteolysis and promotes breast tumour growth.</strong> Nature 417: 871-875, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12075357/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12075357</a>] [<a href="https://doi.org/10.1038/nature00826" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12075357">Urano et al. (2002)</a> demonstrated that EFP is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma (<a href="/entry/601290">601290</a>), a negative cell cycle regulator that causes G2 arrest. <a href="#7" class="mim-tip-reference" title="Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S. <strong>Efp targets 14-3-3-sigma for proteolysis and promotes breast tumour growth.</strong> Nature 417: 871-875, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12075357/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12075357</a>] [<a href="https://doi.org/10.1038/nature00826" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12075357">Urano et al. (2002)</a> demonstrated that tumor growth of breast cancer MCF7 cells implanted in female athymic mice is reduced by treatment with antisense Efp oligonucleotide. Efp-overexpressing MCF7 cells in ovariectomized athymic mice generated tumors in the absence of estrogen. Loss of Efp function in mouse embryonic fibroblasts resulted in an accumulation of 14-3-3-sigma, which was responsible for reduced cell growth. <a href="#7" class="mim-tip-reference" title="Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S. <strong>Efp targets 14-3-3-sigma for proteolysis and promotes breast tumour growth.</strong> Nature 417: 871-875, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12075357/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12075357</a>] [<a href="https://doi.org/10.1038/nature00826" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12075357">Urano et al. (2002)</a> concluded that their data provide an insight into the cell cycle machinery and tumorigenesis of breast cancer by identifying 14-3-3-sigma as a target for proteolysis by EFP, leading to cell proliferation. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12075357" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#1" class="mim-tip-reference" title="Gack, M. U., Shin, Y. C., Joo, C.-H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., Jung, J. U. <strong>TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.</strong> Nature 446: 916-920, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17392790/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17392790</a>] [<a href="https://doi.org/10.1038/nature05732" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17392790">Gack et al. (2007)</a> reported that the N-terminal caspase recruitment domains (CARDs) of RIGI (<a href="/entry/609631">609631</a>) undergo robust ubiquitination induced by TRIM25 in mammalian cells. The C-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIGI; this interaction effectively delivers the lys63-linked ubiquitin moiety to the N-terminal CARDs of RIGI, resulting in a marked increase in RIGI downstream signaling activity. The lys172 residue of RIGI is critical for efficient TRIM25-mediated ubiquitination and for MAVS (<a href="/entry/609676">609676</a>) binding, as well as the ability of RIGI to induce antiviral signal transduction. Gene targeting demonstrated that TRIM25 is essential not only for RIGI ubiquitination but also for RIGI-mediated interferon-beta (see <a href="/entry/147640">147640</a>) production and antiviral activity in response to RNA virus infection. Thus, <a href="#1" class="mim-tip-reference" title="Gack, M. U., Shin, Y. C., Joo, C.-H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., Jung, J. U. <strong>TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.</strong> Nature 446: 916-920, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17392790/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17392790</a>] [<a href="https://doi.org/10.1038/nature05732" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17392790">Gack et al. (2007)</a> demonstrated that TRIM25 E3 ubiquitin ligase induces the lys63-linked ubiquitination of RIGI, which is crucial for the cytosolic RIGI signaling pathway to elicit host antiviral innate immunity. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17392790" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Dengue virus (see <a href="/entry/614371">614371</a>) may become more virulent or show greater outbreak potential in a population exposed to new viral strains. <a href="#5" class="mim-tip-reference" title="Manokaran, G., Finol, E., Wang, C., Gunaratne, J., Bahl, J., Ong, E. Z., Tan, H. C., Sessions, O. M., Ward, A. M., Gubler, D. J., Harris, E., Garcia-Blanco, M. A., Ooi, E. E. <strong>Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.</strong> Science 350: 217-221, 2015.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/26138103/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">26138103</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=26138103[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1126/science.aab3369" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="26138103">Manokaran et al. (2015)</a> identified a determinant of fitness in a new clade (PR-2B) of Dengue virus serotype-2 (DENV-2) that became dominant during a 1994 epidemic in Puerto Rico and replaced an endemic clade (PR-1) of DENV-2. PR-2B DENV-2 showed increased levels of subgenomic flavivirus RNA (sfRNA) compared with genomic RNA during replication. PR-2B sfRNA exhibited sequence-dependent binding to and prevention of TRIM25 deubiquitylation, which is required for sustained and amplified RIGI-induced type I interferon (see <a href="/entry/147640">147640</a>) expression. <a href="#5" class="mim-tip-reference" title="Manokaran, G., Finol, E., Wang, C., Gunaratne, J., Bahl, J., Ong, E. Z., Tan, H. C., Sessions, O. M., Ward, A. M., Gubler, D. J., Harris, E., Garcia-Blanco, M. A., Ooi, E. E. <strong>Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.</strong> Science 350: 217-221, 2015.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/26138103/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">26138103</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=26138103[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1126/science.aab3369" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="26138103">Manokaran et al. (2015)</a> concluded that a distinctive viral RNA-host protein interaction leads to evasion of the innate immune response, resulting in increased epidemiologic fitness of the new viral strain. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=26138103" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#6" class="mim-tip-reference" title="Orimo, A., Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, J., Hiroi, H., Shimizu, Y., Suzuki, M., Noda, T., Muramatsu, M. <strong>Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha.</strong> Proc. Nat. Acad. Sci. 96: 12027-12032, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10518570/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10518570</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=10518570[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1073/pnas.96.21.12027" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10518570">Orimo et al. (1999)</a> generated mice carrying a loss-of-function mutation in Efp by gene-targeted mutagenesis. Although Efp -/- mice were viable and fertile in both sexes, the uterus, which expressed abundant estrogen receptor-alpha (<a href="/entry/133430">133430</a>), exhibited significant underdevelopment. When the ovariectomized mutants were subject to 17-beta-estradiol treatment, they showed remarkably attenuated responses to estrogen, as exemplified by decreased interstitial water imbibition and retarded endometrial cell increase, attributable at least in part to the lower ratio of G1 to S-phase progression in epithelial cells. <a href="#6" class="mim-tip-reference" title="Orimo, A., Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, J., Hiroi, H., Shimizu, Y., Suzuki, M., Noda, T., Muramatsu, M. <strong>Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha.</strong> Proc. Nat. Acad. Sci. 96: 12027-12032, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10518570/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10518570</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=10518570[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1073/pnas.96.21.12027" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10518570">Orimo et al. (1999)</a> concluded that EFP is essential for the normal estrogen-induced cell proliferation and uterine swelling and is one of the direct targets of estrogen receptor-alpha. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10518570" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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Gack, M. U., Shin, Y. C., Joo, C.-H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., Jung, J. U.
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<strong>TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.</strong>
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Nature 446: 916-920, 2007.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17392790/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17392790</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17392790" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/nature05732" target="_blank">Full Text</a>]
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Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H., Muramatsu, M.
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<strong>Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.</strong>
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Proc. Nat. Acad. Sci. 90: 11117-11121, 1993.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8248217/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8248217</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8248217" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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Inoue, S., Orimo, A., Matsuda, Y., Inazawa, J., Emi, M., Nakamura, Y., Hori, T., Muramatsu, M.
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<strong>Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family.</strong>
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Genomics 25: 581-583, 1995.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7789997/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7789997</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7789997" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1016/0888-7543(95)80064-s" target="_blank">Full Text</a>]
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Law, D. J., Prasad, M. A., King, S. E., Spranger, K. D., Lee, Y. H., Fox, R. E., Collins, E. E., Gebuhr, T. C., Miller, D. E., Petty, E. M.
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<strong>Localization of the human estrogen-responsive finger protein (EFP) gene (ZNF147) within a YAC contig containing the myeloperoxidase (MPO) gene.</strong>
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Genomics 28: 361-363, 1995.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8530055/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8530055</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8530055" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1006/geno.1995.1160" target="_blank">Full Text</a>]
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Manokaran, G., Finol, E., Wang, C., Gunaratne, J., Bahl, J., Ong, E. Z., Tan, H. C., Sessions, O. M., Ward, A. M., Gubler, D. J., Harris, E., Garcia-Blanco, M. A., Ooi, E. E.
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<strong>Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.</strong>
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Science 350: 217-221, 2015.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/26138103/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">26138103</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=26138103[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=26138103" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1126/science.aab3369" target="_blank">Full Text</a>]
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<a id="Orimo1999" class="mim-anchor"></a>
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<div class="">
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Orimo, A., Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, J., Hiroi, H., Shimizu, Y., Suzuki, M., Noda, T., Muramatsu, M.
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<strong>Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha.</strong>
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Proc. Nat. Acad. Sci. 96: 12027-12032, 1999.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10518570/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10518570</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=10518570[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10518570" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1073/pnas.96.21.12027" target="_blank">Full Text</a>]
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<a id="Urano2002" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S.
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<strong>Efp targets 14-3-3-sigma for proteolysis and promotes breast tumour growth.</strong>
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Nature 417: 871-875, 2002.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12075357/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12075357</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12075357" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/nature00826" target="_blank">Full Text</a>]
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Paul J. Converse - updated : 10/29/2015
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Ada Hamosh - updated : 7/12/2002
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Creation Date:
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<span class="mim-text-font">
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Victor A. McKusick : 3/9/1995
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mgross : 10/29/2015
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alopez : 6/12/2007<br>alopez : 6/12/2007<br>terry : 5/29/2007<br>mgross : 4/30/2007<br>tkritzer : 1/5/2004<br>alopez : 7/16/2002<br>alopez : 7/16/2002<br>terry : 7/12/2002<br>ckniffin : 5/29/2002<br>dkim : 12/16/1998<br>dkim : 6/26/1998<br>jenny : 11/5/1997<br>mark : 8/25/1995<br>carol : 3/10/1995<br>carol : 3/9/1995
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<strong>*</strong> 600453
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TRIPARTITE MOTIF-CONTAINING PROTEIN 25; TRIM25
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ZINC FINGER PROTEIN 147; ZNF147<br />
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ESTROGEN-RESPONSIVE FINGER PROTEIN; EFP
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<strong><em>HGNC Approved Gene Symbol: TRIM25</em></strong>
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Cytogenetic location: 17q22
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Genomic coordinates <span class="small">(GRCh38)</span> : 17:56,887,909-56,914,049 </span>
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</em>
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<span class="small">(from NCBI)</span>
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<strong>Cloning and Expression</strong>
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<p>The human estrogen-responsive finger protein, a member of the RING finger protein family, was isolated by Inoue et al. (1993) from a human placenta cDNA library using an estrogen receptor-binding fragment containing an estrogen-responsive element. Since this estrogen-responsive finger protein is induced by estrogen via an estrogen-responsive element (ERE) in the 3-prime untranslated region of the gene, it is an attractive candidate for the correlation between estradiol levels and breast/ovarian cancer risk. </p>
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<strong>Mapping</strong>
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<p>By fluorescence in situ hybridization, Inoue et al. (1995) demonstrated that the human EFP gene, also called ZNF147, is located on 17q23.1 and that mouse Efp is located at 11C. Law et al. (1995) demonstrated that the ZNF147 gene is located within a YAC contig containing the myeloperoxidase (MPO; 606989) gene. Approximately 300 kb separate the 2 loci. This result was confirmed by fluorescence in situ hybridization, which again showed that the EFP gene is located at 17q23.1 and refined the assignment of the location of MPO to the same site. At the same time, they mapped the homologous gene in the mouse to chromosome 11 near the Mpo gene. </p>
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<strong>Gene Function</strong>
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<p>Urano et al. (2002) demonstrated that EFP is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma (601290), a negative cell cycle regulator that causes G2 arrest. Urano et al. (2002) demonstrated that tumor growth of breast cancer MCF7 cells implanted in female athymic mice is reduced by treatment with antisense Efp oligonucleotide. Efp-overexpressing MCF7 cells in ovariectomized athymic mice generated tumors in the absence of estrogen. Loss of Efp function in mouse embryonic fibroblasts resulted in an accumulation of 14-3-3-sigma, which was responsible for reduced cell growth. Urano et al. (2002) concluded that their data provide an insight into the cell cycle machinery and tumorigenesis of breast cancer by identifying 14-3-3-sigma as a target for proteolysis by EFP, leading to cell proliferation. </p><p>Gack et al. (2007) reported that the N-terminal caspase recruitment domains (CARDs) of RIGI (609631) undergo robust ubiquitination induced by TRIM25 in mammalian cells. The C-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIGI; this interaction effectively delivers the lys63-linked ubiquitin moiety to the N-terminal CARDs of RIGI, resulting in a marked increase in RIGI downstream signaling activity. The lys172 residue of RIGI is critical for efficient TRIM25-mediated ubiquitination and for MAVS (609676) binding, as well as the ability of RIGI to induce antiviral signal transduction. Gene targeting demonstrated that TRIM25 is essential not only for RIGI ubiquitination but also for RIGI-mediated interferon-beta (see 147640) production and antiviral activity in response to RNA virus infection. Thus, Gack et al. (2007) demonstrated that TRIM25 E3 ubiquitin ligase induces the lys63-linked ubiquitination of RIGI, which is crucial for the cytosolic RIGI signaling pathway to elicit host antiviral innate immunity. </p><p>Dengue virus (see 614371) may become more virulent or show greater outbreak potential in a population exposed to new viral strains. Manokaran et al. (2015) identified a determinant of fitness in a new clade (PR-2B) of Dengue virus serotype-2 (DENV-2) that became dominant during a 1994 epidemic in Puerto Rico and replaced an endemic clade (PR-1) of DENV-2. PR-2B DENV-2 showed increased levels of subgenomic flavivirus RNA (sfRNA) compared with genomic RNA during replication. PR-2B sfRNA exhibited sequence-dependent binding to and prevention of TRIM25 deubiquitylation, which is required for sustained and amplified RIGI-induced type I interferon (see 147640) expression. Manokaran et al. (2015) concluded that a distinctive viral RNA-host protein interaction leads to evasion of the innate immune response, resulting in increased epidemiologic fitness of the new viral strain. </p>
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<strong>Animal Model</strong>
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<p>Orimo et al. (1999) generated mice carrying a loss-of-function mutation in Efp by gene-targeted mutagenesis. Although Efp -/- mice were viable and fertile in both sexes, the uterus, which expressed abundant estrogen receptor-alpha (133430), exhibited significant underdevelopment. When the ovariectomized mutants were subject to 17-beta-estradiol treatment, they showed remarkably attenuated responses to estrogen, as exemplified by decreased interstitial water imbibition and retarded endometrial cell increase, attributable at least in part to the lower ratio of G1 to S-phase progression in epithelial cells. Orimo et al. (1999) concluded that EFP is essential for the normal estrogen-induced cell proliferation and uterine swelling and is one of the direct targets of estrogen receptor-alpha. </p>
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<span class="mim-font">
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<strong>REFERENCES</strong>
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</span>
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</h4>
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<div>
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<p />
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</div>
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<ol>
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<p class="mim-text-font">
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Gack, M. U., Shin, Y. C., Joo, C.-H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., Jung, J. U.
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<strong>TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.</strong>
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Nature 446: 916-920, 2007.
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[PubMed: 17392790]
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[Full Text: https://doi.org/10.1038/nature05732]
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Inoue, S., Orimo, A., Hosoi, T., Kondo, S., Toyoshima, H., Kondo, T., Ikegami, A., Ouchi, Y., Orimo, H., Muramatsu, M.
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<strong>Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.</strong>
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Proc. Nat. Acad. Sci. 90: 11117-11121, 1993.
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[PubMed: 8248217]
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[Full Text: https://doi.org/10.1073/pnas.90.23.11117]
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Inoue, S., Orimo, A., Matsuda, Y., Inazawa, J., Emi, M., Nakamura, Y., Hori, T., Muramatsu, M.
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<strong>Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family.</strong>
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Genomics 25: 581-583, 1995.
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[PubMed: 7789997]
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[Full Text: https://doi.org/10.1016/0888-7543(95)80064-s]
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Law, D. J., Prasad, M. A., King, S. E., Spranger, K. D., Lee, Y. H., Fox, R. E., Collins, E. E., Gebuhr, T. C., Miller, D. E., Petty, E. M.
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<strong>Localization of the human estrogen-responsive finger protein (EFP) gene (ZNF147) within a YAC contig containing the myeloperoxidase (MPO) gene.</strong>
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Genomics 28: 361-363, 1995.
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[PubMed: 8530055]
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[Full Text: https://doi.org/10.1006/geno.1995.1160]
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Manokaran, G., Finol, E., Wang, C., Gunaratne, J., Bahl, J., Ong, E. Z., Tan, H. C., Sessions, O. M., Ward, A. M., Gubler, D. J., Harris, E., Garcia-Blanco, M. A., Ooi, E. E.
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<strong>Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.</strong>
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Science 350: 217-221, 2015.
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[PubMed: 26138103]
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[Full Text: https://doi.org/10.1126/science.aab3369]
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Orimo, A., Inoue, S., Minowa, O., Tominaga, N., Tomioka, Y., Sato, M., Kuno, J., Hiroi, H., Shimizu, Y., Suzuki, M., Noda, T., Muramatsu, M.
|
|
<strong>Underdeveloped uterus and reduced estrogen responsiveness in mice with disruption of the estrogen-responsive finger protein gene, which is a direct target of estrogen receptor alpha.</strong>
|
|
Proc. Nat. Acad. Sci. 96: 12027-12032, 1999.
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[PubMed: 10518570]
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[Full Text: https://doi.org/10.1073/pnas.96.21.12027]
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<p class="mim-text-font">
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Urano, T., Saito, T., Tsukui, T., Fujita, M., Hosoi, T., Muramatsu, M., Ouchi, Y., Inoue, S.
|
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<strong>Efp targets 14-3-3-sigma for proteolysis and promotes breast tumour growth.</strong>
|
|
Nature 417: 871-875, 2002.
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[PubMed: 12075357]
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[Full Text: https://doi.org/10.1038/nature00826]
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Paul J. Converse - updated : 10/29/2015<br>Ada Hamosh - updated : 7/12/2002
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Victor A. McKusick : 3/9/1995
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mgross : 10/29/2015<br>alopez : 6/12/2007<br>alopez : 6/12/2007<br>terry : 5/29/2007<br>mgross : 4/30/2007<br>tkritzer : 1/5/2004<br>alopez : 7/16/2002<br>alopez : 7/16/2002<br>terry : 7/12/2002<br>ckniffin : 5/29/2002<br>dkim : 12/16/1998<br>dkim : 6/26/1998<br>jenny : 11/5/1997<br>mark : 8/25/1995<br>carol : 3/10/1995<br>carol : 3/9/1995
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