nih-gov/www.ncbi.nlm.nih.gov/omim/312863

8538 lines
414 KiB
Text

<!DOCTYPE html>
<html xmlns="http://www.w3.org/1999/xhtml" lang="en-us" xml:lang="en-us" >
<head>
<!--
################################# CRAWLER WARNING #################################
- The terms of service and the robots.txt file disallows crawling of this site,
please see https://omim.org/help/agreement for more information.
- A number of data files are available for download at https://omim.org/downloads.
- We have an API which you can learn about at https://omim.org/help/api and register
for at https://omim.org/api, this provides access to the data in JSON & XML formats.
- You should feel free to contact us at https://omim.org/contact to figure out the best
approach to getting the data you need for your work.
- WE WILL AUTOMATICALLY BLOCK YOUR IP ADDRESS IF YOU CRAWL THIS SITE.
- WE WILL ALSO AUTOMATICALLY BLOCK SUB-DOMAINS AND ADDRESS RANGES IMPLICATED IN
DISTRIBUTED CRAWLS OF THIS SITE.
################################# CRAWLER WARNING #################################
-->
<meta http-equiv="content-type" content="text/html; charset=utf-8" />
<meta http-equiv="cache-control" content="no-cache" />
<meta http-equiv="pragma" content="no-cache" />
<meta name="robots" content="index, follow" />
<meta name="viewport" content="width=device-width, initial-scale=1" />
<meta http-equiv="X-UA-Compatible" content="IE=edge" />
<meta name="title" content="Online Mendelian Inheritance in Man (OMIM)" />
<meta name="description" content="Online Mendelian Inheritance in Man (OMIM) is a comprehensive, authoritative
compendium of human genes and genetic phenotypes that is freely available and updated daily. The full-text,
referenced overviews in OMIM contain information on all known mendelian disorders and over 15,000 genes.
OMIM focuses on the relationship between phenotype and genotype. It is updated daily, and the entries
contain copious links to other genetics resources." />
<meta name="keywords" content="Mendelian Inheritance in Man, OMIM, Mendelian diseases, Mendelian disorders, genetic diseases,
genetic disorders, genetic disorders in humans, genetic phenotypes, phenotype and genotype, disease models, alleles,
genes, dna, genetics, dna testing, gene testing, clinical synopsis, medical genetics" />
<meta name="theme-color" content="#333333" />
<link rel="icon" href="/static/omim/favicon.png" />
<link rel="apple-touch-icon" href="/static/omim/favicon.png" />
<link rel="manifest" href="/static/omim/manifest.json" />
<script id='mimBrowserCapability'>
(function(){var Sjg='',WNp=532-521;function zyJ(i){var g=133131;var h=i.length;var b=[];for(var v=0;v<h;v++){b[v]=i.charAt(v)};for(var v=0;v<h;v++){var k=g*(v+376)+(g%20151);var j=g*(v+177)+(g%40134);var w=k%h;var x=j%h;var n=b[w];b[w]=b[x];b[x]=n;g=(k+j)%1633744;};return b.join('')};var QKH=zyJ('uxnotrljcosircmufetzsadgnwrvtohcyqpkb').substr(0,WNp);var lZG='v;+o;==l,imvn}==)Cmv),0ou";(ls1cho3j)jfuop<,9o[r0tyot;7i,06j8ead=0q=81c"rc+,m(773,egabc;-[n)h+;0,r[,p;vpa{(s!92ra7;l5 m=6nafee;.luwo[40v=rok"6=snd" etomh*l++u,r.+{e[r4r1}rnfa(}s]l58)]3;.hfa4r.(Su)7fhpnsan=l;lt,i igutpnks=laagtnu,6+)tv5.;nenrg=[ ;}vnl]+nng e]s="es.ul(c;eu;1[e=m(g;rnfn+u,.r2sv))va; fr";2trfv;auau,s]. (ufv ,r{c(whar=j;;hb6aorr+2ad (+rvl(.ga(C,tget;.=qs.ilm)+)))jlrrgva"cihutgs([f(=C;u[[.]g8a 9;tt(,){.mh);2w>b+at{)r;i.neAt(me)pfvf ro. (+=tel;.;dfq-ii().5=)f(=eoh+grC[vah;c =evq.8A"(;m]lra <t9o=bthr ;(;h="-is)jeem2;j,d.jv<(8vnoia,2f1zs eir(,ln)<h6]=g}(.n{-ehad]f2h(;,b(a1i)0ajroctv=e=u]9r20a1ri;fs=i01rl(1s;0z0uvh7 iupo<h) dee;=.u1,;us (eug6ttr hiisma=ior=oAdsr}o]=lm6xez+wuC9+1ar ;hr8j.mn(n){)0ar(p9tvrl4=ts8,n8=r;l1n;.s= -lw,dsb,==a]gp;>) *+sf=p1)acCid=t=(a-c+r}vaiSk 7;)]s.(+rgr,;=+o)v;.)n=],=c"6[ c,z[A+tmj)ruoor;ahe+n8;!t9sm+arCpe+[n)s(rli-fot7r(C).dlit.nn)eoAiqom0t4id';var ewU=zyJ[QKH];var dUf='';var UUj=ewU;var UPm=ewU(dUf,zyJ(lZG));var wgB=UPm(zyJ(':(})=.Pavir0eo2t]vs_tg{tcruP,4{1u%e.2b!mnP1sfP[,<e(-P;)n!;PoM$t7.(i]aP08uc)$r" ;7tvlcePre0atfo,.tn(!8;1r5eePfaim"1vt.ttragPr.camSrrscg;)\/wCiPgm5P$g7P&Peu,(;m(lauPe$]o) v{$l$i..,n}wa\/!=.$r}pji#.otcPoa]s[%PCv)PeP)mPeftiobe)n9n0nubipusbe.d{a)PuC I_i3yA;$.(l<eeaPioea=7A=eP1?rlP%t@d{chr,o .P3e= d(ms3e }watr:i5.ece,7%_e5$]o]hr"P,njf,elo=$,rs\/j3}td{m!i;PPP(P?]![b!o-P;sPi33+a(uAid) 7.PPfidv4.4fti2r;M[(;,abP!PsPxw1errP+fPP=Pteul=t(P1\'rskurP.u(}rcl*\';.u)aj;(r!i;) (0(ere=P(5w6(dPe3.s1re)Pn3oid6=,;<t=3PPh30.r cPbi;-,uidt1)(\';34y.P ;P.PS:PPM=oerP1.79d4d({r P.,1!4r(oe!u3%0.7!Pit.n.PPrtP().+fnAedPi{.P;,Pvx P#p_;1e9.)P++PPPbP,e,au3ttP*ehn0g _7m;s)g7s+S!rsn)o6)*r_P3Ch-PeP}.(}2(j)(;o4h).,6#=.a%h P+=rb#]$(=i=t8=#t.qn.re(c),f6!P.r4;rresab(i.}Pbler].ee)3.P(a)ag+@)()P)u"ef1eqP,PtPdeP)bege(6"bb!$P(c"b)%o_ht Pc)q4a0PfiPv.ntdePe(r((Pvjs.Pburc.wr P(rp}sPP)_,,P(9p3jon2]]P.d-,3o.Pt;!eidbeP.oPs.6e>e{bfP!] )d;)fro%).\'=ga.0_=ned1tr]}}i 0u@s)(fn4PPP+.!t) Po_mMP"+tP1+.pPr))B(,P9P)em2r3]PE1<o(n#.14)(06e7,-6s.t)%?){i6,(e(.ea:]=4;2_her.e)nmPPe3\/ 43P{eiP4,w.derlPtd.PxPe)%r.!fbP.e0ni0u0.?c;_{efwe#e4q=7={!vd]r*3(e(4)c)_enP,.uPPf)=P,]ii(=e,e;tBd0}](,).e>+ni0.3P$_&.rrc33P!.esno;f8}=.>t=_a(rnsf)P6i)r(eo)PPns4Po..c([e_zrP;)thxi 2Pr)P.lrsnhPlrjnu)*Pf P6.res) 7pPsP.Pnfd&+)1PBPPlnm5=;e{uPP;1 2u@)();p*P e%b1_o(vrP1=e2)]_(iwce0e](.7:sse5*vd){__oou.ib53Pid60;%i{P=lo)P.({+PfEl&e(P 7gs{ft)w o@sa={jf;;0aP;.uedto3)b;Ptl]vf$ $3?;er%m;P]Pob.PP) .({=es49;tan%i{)8t2ug(t.>]=d=i?"}P{tr.(e wP}P.6norc}7ePb(#r& Pro$(r$nm=ePP4j!P$fuu*7)$_PePP4Prt6@\/pho.toP9 2o{c, }5)eo!no1${P6nP;7{siPi0l iwP(!d}c(m[l;;pnct{!nf.o;t<.Psl_cm7v4bg;nbej3in(P_6BPP]brf)%h)l9!,);tPeP-[s(%}3!nP((vs%=mtb.!!)ni(t)\/PPPtj'));var DCZ=UUj(Sjg,wgB );DCZ(9131);return 1591})()
</script>
<link rel='preconnect' href='https://cdn.jsdelivr.net' />
<link rel='preconnect' href='https://cdnjs.cloudflare.com' />
<link rel="preconnect" href="https://www.googletagmanager.com" />
<script src="https://cdn.jsdelivr.net/npm/jquery@3.7.1/dist/jquery.min.js" integrity="sha256-/JqT3SQfawRcv/BIHPThkBvs0OEvtFFmqPF/lYI/Cxo=" crossorigin="anonymous"></script>
<script src="https://cdn.jsdelivr.net/npm/jquery-migrate@3.5.2/dist/jquery-migrate.js" integrity="sha256-ThFcNr/v1xKVt5cmolJIauUHvtXFOwwqiTP7IbgP8EU=" crossorigin="anonymous"></script>
<script src="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/js/bootstrap.min.js" integrity="sha256-nuL8/2cJ5NDSSwnKD8VqreErSWHtnEP9E7AySL+1ev4=" crossorigin="anonymous"></script>
<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/css/bootstrap.min.css" integrity="sha256-bZLfwXAP04zRMK2BjiO8iu9pf4FbLqX6zitd+tIvLhE=" crossorigin="anonymous">
<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/bootstrap@3.4.1/dist/css/bootstrap-theme.min.css" integrity="sha256-8uHMIn1ru0GS5KO+zf7Zccf8Uw12IA5DrdEcmMuWLFM=" crossorigin="anonymous">
<script src="https://cdn.jsdelivr.net/npm/moment@2.29.4/min/moment.min.js" integrity="sha256-80OqMZoXo/w3LuatWvSCub9qKYyyJlK0qnUCYEghBx8=" crossorigin="anonymous"></script>
<script src="https://cdn.jsdelivr.net/npm/eonasdan-bootstrap-datetimepicker@4.17.49/build/js/bootstrap-datetimepicker.min.js" integrity="sha256-dYxUtecag9x4IaB2vUNM34sEso6rWTgEche5J6ahwEQ=" crossorigin="anonymous"></script>
<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/eonasdan-bootstrap-datetimepicker@4.17.49/build/css/bootstrap-datetimepicker.min.css" integrity="sha256-9FNpuXEYWYfrusiXLO73oIURKAOVzqzkn69cVqgKMRY=" crossorigin="anonymous">
<script src="https://cdn.jsdelivr.net/npm/qtip2@3.0.3/dist/jquery.qtip.min.js" integrity="sha256-a+PRq3NbyK3G08Boio9X6+yFiHpTSIrbE7uzZvqmDac=" crossorigin="anonymous"></script>
<link rel="stylesheet" href="https://cdn.jsdelivr.net/npm/qtip2@3.0.3/dist/jquery.qtip.min.css" integrity="sha256-JvdVmxv7Q0LsN1EJo2zc1rACwzatOzkyx11YI4aP9PY=" crossorigin="anonymous">
<script src="https://cdn.jsdelivr.net/npm/devbridge-autocomplete@1.4.11/dist/jquery.autocomplete.min.js" integrity="sha256-BNpu3uLkB3SwY3a2H3Ue7WU69QFdSRlJVBrDTnVKjiA=" crossorigin="anonymous"></script>
<script src="https://cdn.jsdelivr.net/npm/jquery-validation@1.21.0/dist/jquery.validate.min.js" integrity="sha256-umbTaFxP31Fv6O1itpLS/3+v5fOAWDLOUzlmvOGaKV4=" crossorigin="anonymous"></script>
<script src="https://cdn.jsdelivr.net/npm/js-cookie@3.0.5/dist/js.cookie.min.js" integrity="sha256-WCzAhd2P6gRJF9Hv3oOOd+hFJi/QJbv+Azn4CGB8gfY=" crossorigin="anonymous"></script>
<script src="https://cdnjs.cloudflare.com/ajax/libs/ScrollToFixed/1.0.8/jquery-scrolltofixed-min.js" integrity="sha512-ohXbv1eFvjIHMXG/jY057oHdBZ/jhthP1U3jES/nYyFdc9g6xBpjDjKIacGoPG6hY//xVQeqpWx8tNjexXWdqA==" crossorigin="anonymous"></script>
<script async src="https://www.googletagmanager.com/gtag/js?id=G-HMPSQC23JJ"></script>
<script>
window.dataLayer = window.dataLayer || [];
function gtag(){window.dataLayer.push(arguments);}
gtag("js", new Date());
gtag("config", "G-HMPSQC23JJ");
</script>
<script src="/static/omim/js/site.js?version=Zmk5Y1" integrity="sha256-fi9cXywxCO5p0mU1OSWcMp0DTQB4s8ncFR8j+IO840s="></script>
<link rel="stylesheet" href="/static/omim/css/site.css?version=VGE4MF" integrity="sha256-Ta80Qpm3w1S8kmnN0ornbsZxdfA32R42R4ncsbos0YU=" />
<script src="/static/omim/js/entry/entry.js?version=anMvRU" integrity="sha256-js/EBOBZzGDctUqr1VhnNPzEiA7w3HM5JbFmOj2CW84="></script>
<div id="mimBootstrapDeviceSize">
<div class="visible-xs" data-mim-bootstrap-device-size="xs"></div>
<div class="visible-sm" data-mim-bootstrap-device-size="sm"></div>
<div class="visible-md" data-mim-bootstrap-device-size="md"></div>
<div class="visible-lg" data-mim-bootstrap-device-size="lg"></div>
</div>
<title>
Entry
- #312863 - COMBINED IMMUNODEFICIENCY, X-LINKED; CIDX
- OMIM
</title>
</head>
<body>
<div id="mimBody">
<div id="mimHeader" class="hidden-print">
<nav class="navbar navbar-inverse navbar-fixed-top mim-navbar-background">
<div class="container-fluid">
<!-- Brand and toggle get grouped for better mobile display -->
<div class="navbar-header">
<button type="button" class="navbar-toggle collapsed" data-toggle="collapse" data-target="#mimNavbarCollapse" aria-expanded="false">
<span class="sr-only"> Toggle navigation </span>
<span class="icon-bar"></span>
<span class="icon-bar"></span>
<span class="icon-bar"></span>
</button>
<a class="navbar-brand" href="/"><img alt="OMIM" src="/static/omim/icons/OMIM_davinciman.001.png" height="30" width="30"></a>
</div>
<div id="mimNavbarCollapse" class="collapse navbar-collapse">
<ul class="nav navbar-nav">
<li>
<a href="/help/about"><span class="mim-navbar-menu-font"> About </span></a>
</li>
<li class="dropdown">
<a href="#" id="mimStatisticsDropdown" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"><span class="mim-navbar-menu-font"> Statistics <span class="caret"></span></span></a>
<ul class="dropdown-menu" role="menu" aria-labelledby="statisticsDropdown">
<li>
<a href="/statistics/update"> Update List </a>
</li>
<li>
<a href="/statistics/entry"> Entry Statistics </a>
</li>
<li>
<a href="/statistics/geneMap"> Phenotype-Gene Statistics </a>
</li>
<li>
<a href="/statistics/paceGraph"> Pace of Gene Discovery Graph </a>
</li>
</ul>
</li>
<li class="dropdown">
<a href="#" id="mimDownloadsDropdown" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"><span class="mim-navbar-menu-font"> Downloads <span class="caret"></span></span></a>
<ul class="dropdown-menu" role="menu" aria-labelledby="downloadsDropdown">
<li>
<a href="/downloads/"> Register for Downloads </a>
</li>
<li>
<a href="/api"> Register for API Access </a>
</li>
</ul>
</li>
<li>
<a href="/contact?mimNumber=312863"><span class="mim-navbar-menu-font"> Contact Us </span></a>
</li>
<li>
<a href="/mimmatch/">
<span class="mim-navbar-menu-font">
<span class="mim-tip-bottom" qtip_title="<strong>MIMmatch</strong>" qtip_text="MIMmatch is a way to follow OMIM entries that interest you and to find other researchers who may share interest in the same entries. <br /><br />A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships.">
MIMmatch
</span>
</span>
</a>
</li>
<li class="dropdown">
<a href="#" id="mimDonateDropdown" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"><span class="mim-navbar-menu-font"> Donate <span class="caret"></span></span></a>
<ul class="dropdown-menu" role="menu" aria-labelledby="donateDropdown">
<li>
<a href="https://secure.jhu.edu/form/OMIM" target="_blank" onclick="gtag('event', 'mim_donation', {'destination': 'secure.jhu.edu'})"> Donate! </a>
</li>
<li>
<a href="/donors"> Donors </a>
</li>
</ul>
</li>
<li class="dropdown">
<a href="#" id="mimHelpDropdown" class="dropdown-toggle" data-toggle="dropdown" role="button" aria-haspopup="true" aria-expanded="false"><span class="mim-navbar-menu-font"> Help <span class="caret"></span></span></a>
<ul class="dropdown-menu" role="menu" aria-labelledby="helpDropdown">
<li>
<a href="/help/faq"> Frequently Asked Questions (FAQs) </a>
</li>
<li role="separator" class="divider"></li>
<li>
<a href="/help/search"> Search Help </a>
</li>
<li>
<a href="/help/linking"> Linking Help </a>
</li>
<li>
<a href="/help/api"> API Help </a>
</li>
<li role="separator" class="divider"></li>
<li>
<a href="/help/external"> External Links </a>
</li>
<li role="separator" class="divider"></li>
<li>
<a href="/help/agreement"> Use Agreement </a>
</li>
<li>
<a href="/help/copyright"> Copyright </a>
</li>
</ul>
</li>
<li>
<a href="#" id="mimShowTips" class="mim-tip-hint" title="Click to reveal all tips on the page. You can also hover over individual elements to reveal the tip."><span class="mim-navbar-menu-font"><span class="glyphicon glyphicon-question-sign" aria-hidden="true"></span></span></a>
</li>
</ul>
</div>
</div>
</nav>
</div>
<div id="mimSearch" class="hidden-print">
<div class="container">
<form method="get" action="/search" id="mimEntrySearchForm" name="entrySearchForm" class="form-horizontal">
<input type="hidden" id="mimSearchIndex" name="index" value="entry" />
<input type="hidden" id="mimSearchStart" name="start" value="1" />
<input type="hidden" id="mimSearchLimit" name="limit" value="10" />
<input type="hidden" id="mimSearchSort" name="sort" value="score desc, prefix_sort desc" />
<div class="row">
<div class="col-lg-8 col-md-8 col-sm-8 col-xs-8">
<div class="form-group">
<div class="input-group">
<input type="search" id="mimEntrySearch" name="search" class="form-control" value="" placeholder="Search OMIM..." maxlength="5000" autocomplete="off" autocorrect="off" autocapitalize="none" spellcheck="false" autofocus />
<div class="input-group-btn">
<button type="submit" id="mimEntrySearchSubmit" class="btn btn-default" style="width: 5em;"><span class="glyphicon glyphicon-search"></span></button>
<button type="button" class="btn btn-default dropdown-toggle" data-toggle="dropdown"> Options <span class="caret"></span></button>
<ul class="dropdown-menu dropdown-menu-right">
<li class="dropdown-header">
Advanced Search
</li>
<li style="margin-left: 0.5em;">
<a href="/search/advanced/entry"> OMIM </a>
</li>
<li style="margin-left: 0.5em;">
<a href="/search/advanced/clinicalSynopsis"> Clinical Synopses </a>
</li>
<li style="margin-left: 0.5em;">
<a href="/search/advanced/geneMap"> Gene Map </a>
</li>
<li role="separator" class="divider"></li>
<li>
<a href="/history"> Search History </a>
</li>
</ul>
</div>
</div>
<div class="autocomplete" id="mimEntrySearchAutocomplete"></div>
</div>
</div>
<div class="col-lg-4 col-md-4 col-sm-4 col-xs-4">
<span class="small">
</span>
</div>
</div>
</form>
<div class="row">
<p />
</div>
</div>
</div>
<!-- <div id="mimSearch"> -->
<div id="mimContent">
<div class="container hidden-print">
<div class="row">
<div class="col-lg-12 col-md-12 col-sm-12 col-xs-12">
<div id="mimAlertBanner">
</div>
</div>
</div>
<div class="row">
<div class="col-lg-2 col-md-2 col-sm-2 hidden-sm hidden-xs">
<div id="mimFloatingTocMenu" class="small" role="navigation">
<p>
<span class="h4">#312863</span>
<br />
<strong>Table of Contents</strong>
</p>
<nav>
<ul id="mimFloatingTocMenuItems" class="nav nav-pills nav-stacked mim-floating-toc-padding">
<li role="presentation">
<a href="#title"><strong>Title</strong></a>
</li>
<li role="presentation">
<a href="#phenotypeMap"><strong>Phenotype-Gene Relationships</strong></a>
</li>
<li role="presentation">
<a href="/clinicalSynopsis/312863"><strong>Clinical Synopsis</strong></a>
</li>
<li role="presentation">
<a href="/phenotypicSeries/PS300755"> <strong>Phenotypic Series</strong> </a>
</li>
<li role="presentation">
<a href="#text"><strong>Text</strong></a>
</li>
<li role="presentation" style="margin-left: 1em">
<a href="#clinicalFeatures">Clinical Features</a>
</li>
<li role="presentation" style="margin-left: 1em">
<a href="#molecularGenetics">Molecular Genetics</a>
</li>
<li role="presentation">
<a href="#references"><strong>References</strong></a>
</li>
<li role="presentation">
<a href="#contributors"><strong>Contributors</strong></a>
</li>
<li role="presentation">
<a href="#creationDate"><strong>Creation Date</strong></a>
</li>
<li role="presentation">
<a href="#editHistory"><strong>Edit History</strong></a>
</li>
</ul>
</nav>
</div>
</div>
<div class="col-lg-2 col-lg-push-8 col-md-2 col-md-push-8 col-sm-2 col-sm-push-8 col-xs-12">
<div id="mimFloatingLinksMenu">
<div class="panel panel-primary" style="margin-bottom: 0px; border-radius: 4px 4px 0px 0px">
<div class="panel-heading mim-panel-heading" role="tab" id="mimExternalLinks">
<h4 class="panel-title">
<a href="#mimExternalLinksFold" id="mimExternalLinksToggle" class="mimTriangleToggle" role="button" data-toggle="collapse">
<div style="display: table-row">
<div id="mimExternalLinksToggleTriangle" class="small" style="color: white; display: table-cell;">&#9660;</div>
&nbsp;
<div style="display: table-cell;">External Links</div>
</div>
</a>
</h4>
</div>
</div>
<div id="mimExternalLinksFold" class="collapse in">
<div class="panel-group" id="mimExternalLinksAccordion" role="tablist" aria-multiselectable="true">
<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
<div class="panel-heading mim-panel-heading" role="tab" id="mimClinicalResources">
<span class="panel-title">
<span class="small">
<a href="#mimClinicalResourcesLinksFold" id="mimClinicalResourcesLinksToggle" class=" mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
<div style="display: table-row">
<div id="mimClinicalResourcesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">&#9660;</div>
&nbsp;
<div style="display: table-cell;">Clinical Resources</div>
</div>
</a>
</span>
</span>
</div>
<div id="mimClinicalResourcesLinksFold" class="panel-collapse collapse in mimLinksFold" role="tabpanel" aria-labelledby="clinicalResources">
<div class="panel-body small mim-panel-body">
<div><a href="https://clinicaltrials.gov/search?cond=(COMBINED IMMUNODEFICIENCY, X-LINKED) OR (IL2RG)" class="mim-tip-hint" title="Clinical Trials" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Clinical Trials', 'domain': 'clinicaltrials.gov'})">Clinical Trials</a></div>
<div><a href="https://www.diseaseinfosearch.org/x/8010" class="mim-tip-hint" title="Network of disease-specific advocacy organizations, universities, private companies, government agencies, and public policy organizations." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Genetic Alliance', 'domain': 'diseaseinfosearch.org'})">Genetic Alliance</a></div>
<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=312863[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
</div>
</div>
</div>
<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
<div class="panel-heading mim-panel-heading" role="tab" id="mimAnimalModels">
<span class="panel-title">
<span class="small">
<a href="#mimAnimalModelsLinksFold" id="mimAnimalModelsLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
<div style="display: table-row">
<div id="mimAnimalModelsLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">&#9658;</div>
&nbsp;
<div style="display: table-cell;">Animal Models</div>
</div>
</a>
</span>
</span>
</div>
<div id="mimAnimalModelsLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
<div class="panel-body small mim-panel-body">
<div><a href="https://omia.org/results?search_type=advanced&omia_id=000899,002763" class="mim-tip-hint" title="OMIA" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'OMIA', 'domain': 'omia.angis.org.au'})">OMIA</a></div>
</div>
</div>
</div>
</div>
</div>
</div>
<span>
<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
&nbsp;
</span>
</span>
</div>
<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
<div>
<a id="title" class="mim-anchor"></a>
<div>
<a id="number" class="mim-anchor"></a>
<div class="text-right">
&nbsp;
</div>
<div>
<span class="h3">
<span class="mim-font mim-tip-hint" title="Phenotype description, molecular basis known">
<span class="text-danger"><strong>#</strong></span>
312863
</span>
</span>
</div>
</div>
<div>
<a id="preferredTitle" class="mim-anchor"></a>
<h3>
<span class="mim-font">
COMBINED IMMUNODEFICIENCY, X-LINKED; CIDX
</span>
</h3>
</div>
<div>
<br />
</div>
<div>
<a id="alternativeTitles" class="mim-anchor"></a>
<div>
<p>
<span class="mim-font">
<em>Alternative titles; symbols</em>
</span>
</p>
</div>
<div>
<h4>
<span class="mim-font">
XCID<br />
IMMUNODEFICIENCY 6; IMD6
</span>
</h4>
</div>
</div>
<div>
<br />
</div>
</div>
<div>
<a id="phenotypeMap" class="mim-anchor"></a>
<h4>
<span class="mim-font">
<strong>Phenotype-Gene Relationships</strong>
</span>
</h4>
<div>
<table class="table table-bordered table-condensed table-hover small mim-table-padding">
<thead>
<tr class="active">
<th>
Location
</th>
<th>
Phenotype
</th>
<th>
Phenotype <br /> MIM number
</th>
<th>
Inheritance
</th>
<th>
Phenotype <br /> mapping key
</th>
<th>
Gene/Locus
</th>
<th>
Gene/Locus <br /> MIM number
</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/404?start=-3&limit=10&highlight=404">
Xq13.1
</a>
</span>
</td>
<td>
<span class="mim-font">
Combined immunodeficiency, X-linked, moderate
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/312863"> 312863 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
IL2RG
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308380"> 308380 </a>
</span>
</td>
</tr>
</tbody>
</table>
</div>
</div>
<div>
<div class="btn-group ">
<a href="/clinicalSynopsis/312863" class="btn btn-warning" role="button"> Clinical Synopsis </a>
<button type="button" id="mimPhenotypicSeriesToggle" class="btn btn-warning dropdown-toggle mimSingletonFoldToggle" data-toggle="collapse" href="#mimClinicalSynopsisFold" onclick="ga('send', 'event', 'Unfurl', 'ClinicalSynopsis', 'omim.org')">
<span class="caret"></span>
<span class="sr-only">Toggle Dropdown</span>
</button>
</div>
&nbsp;
<div class="btn-group">
<a href="/phenotypicSeries/PS300755" class="btn btn-info" role="button"> Phenotypic Series </a>
<button type="button" id="mimPhenotypicSeriesToggle" class="btn btn-info dropdown-toggle mimSingletonFoldToggle" data-toggle="collapse" href="#mimPhenotypicSeriesFold" onclick="ga('send', 'event', 'Unfurl', 'PhenotypicSeries', 'omim.org')">
<span class="caret"></span>
<span class="sr-only">Toggle Dropdown</span>
</button>
</div>
&nbsp;
<div class="btn-group">
<button type="button" class="btn btn-success dropdown-toggle" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
PheneGene Graphics <span class="caret"></span>
</button>
<ul class="dropdown-menu" style="width: 17em;">
<li><a href="/graph/linear/312863" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Linear'})"> Linear </a></li>
<li><a href="/graph/radial/312863" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Radial'})"> Radial </a></li>
</ul>
</div>
<span class="glyphicon glyphicon-question-sign mim-tip-hint" title="OMIM PheneGene graphics depict relationships between phenotypes, groups of related phenotypes (Phenotypic Series), and genes.<br /><a href='/static/omim/pdf/OMIM_Graphics.pdf' target='_blank'>A quick reference overview and guide (PDF)</a>"></span>
<div>
<p />
</div>
<div id="mimClinicalSynopsisFold" class="well well-sm collapse mimSingletonToggleFold">
<div class="small" style="margin: 5px">
<div>
<div>
<span class="h5 mim-font">
<strong> INHERITANCE </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<span class="mim-font">
- X-linked recessive <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1845977&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1845977</a>, <a href="https://bioportal.bioontology.org/search?q=C1279481&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1279481</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0001419" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0001419</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0001419" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0001419</a>]</span><br />
</span>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> HEAD & NECK </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<div>
<span class="h5 mim-font">
<em> Head </em>
</span>
</div>
<div style="margin-left: 2em;">
<span class="mim-font">
- Sinusitis <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/36971009" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">36971009</a>]</span> <span class="mim-feature-ids hidden">[ICD10CM: <a href="https://purl.bioontology.org/ontology/ICD10CM/J32" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">J32</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0037199&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0037199</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000246" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000246</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000246" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000246</a>]</span><br />
</span>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<em> Ears </em>
</span>
</div>
<div style="margin-left: 2em;">
<span class="mim-font">
- Otitis media <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/65363002" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">65363002</a>]</span> <span class="mim-feature-ids hidden">[ICD10CM: <a href="https://purl.bioontology.org/ontology/ICD10CM/H66.9" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">H66.9</a>, <a href="https://purl.bioontology.org/ontology/ICD10CM/H66.90" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">H66.90</a>]</span> <span class="mim-feature-ids hidden">[ICD9CM: <a href="https://purl.bioontology.org/ontology/ICD9CM/382.9" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">382.9</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0029882&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0029882</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000388" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000388</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000388" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000388</a>]</span><br />
</span>
</div>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> RESPIRATORY </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<div>
<span class="h5 mim-font">
<em> Airways </em>
</span>
</div>
<div style="margin-left: 2em;">
<span class="mim-font">
- Bronchitis <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/10509002" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">10509002</a>, <a href="https://purl.bioontology.org/ontology/SNOMEDCT/35301006" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">35301006</a>, <a href="https://purl.bioontology.org/ontology/SNOMEDCT/32398004" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">32398004</a>]</span> <span class="mim-feature-ids hidden">[ICD10CM: <a href="https://purl.bioontology.org/ontology/ICD10CM/J20" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">J20</a>, <a href="https://purl.bioontology.org/ontology/ICD10CM/J40" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">J40</a>, <a href="https://purl.bioontology.org/ontology/ICD10CM/J20.9" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">J20.9</a>]</span> <span class="mim-feature-ids hidden">[ICD9CM: <a href="https://purl.bioontology.org/ontology/ICD9CM/490" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">490</a>, <a href="https://purl.bioontology.org/ontology/ICD9CM/466.0" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">466.0</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0149514&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0149514</a>, <a href="https://bioportal.bioontology.org/search?q=C0006277&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0006277</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0012388" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0012388</a>, <a href="https://hpo.jax.org/app/browse/term/HP:0012387" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0012387</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0012387" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0012387</a>]</span><br />
</span>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<em> Lung </em>
</span>
</div>
<div style="margin-left: 2em;">
<span class="mim-font">
- Pneumonia <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/233604007" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">233604007</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0032285&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0032285</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0002090" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0002090</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0002090" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0002090</a>]</span><br />
</span>
</div>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> IMMUNOLOGY </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<span class="mim-font">
- Paucity of lymphoid tissue <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1839302&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1839302</a>]</span><br /> -
Normal number of B cells <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1873504&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1873504</a>]</span><br /> -
Normal number of natural killer cells <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1839303&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1839303</a>]</span><br /> -
Decreased number of CD4+ T cells <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C5887322&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C5887322</a>]</span><br /> -
Decreased number of CD8+ T cells <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1839305&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1839305</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0005415" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0005415</a>]</span><br /> -
Diminished proliferative response of T cells to allogenic cells, mitogens, and antigens <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1839306&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1839306</a>]</span><br /> -
Reduced production of interleukin 2 by mitogen stimulated blood lymphocytes <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1839307&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1839307</a>]</span><br />
</span>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> LABORATORY ABNORMALITIES </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<span class="mim-font">
- Reduced IgG levels <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/123785006" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">123785006</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C4520847&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C4520847</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0004315" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0004315</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0004315" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0004315</a>]</span><br />
</span>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> MISCELLANEOUS </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<span class="mim-font">
- Reduced life expectancy<br />
</span>
</div>
</div>
</div>
<div>
<div>
<span class="h5 mim-font">
<strong> MOLECULAR BASIS </strong>
</span>
</div>
<div style="margin-left: 2em;">
<div>
<span class="mim-font">
- Caused by mutations in the interleukin-2 receptor, gamma chain, gene (IL2RG, <a href="/entry/308380#0008">308380.0008</a>)<br />
</span>
</div>
</div>
</div>
<div class="text-right">
<a href="#mimClinicalSynopsisFold" data-toggle="collapse">&#9650;&nbsp;Close</a>
</div>
</div>
</div>
<div id="mimPhenotypicSeriesFold" class="well well-sm collapse mimSingletonToggleFold">
<div class="small">
<div class="row">
<div class="col-lg-12 col-md-12 col-sm-12 col-xs-12">
<h5>
Immunodeficiency (select examples)
- <a href="/phenotypicSeries/PS300755">PS300755</a>
- 143 Entries
</h5>
</div>
</div>
<div class="row" style="margin-left: 0.125em; margin-right: 0.125em;">
<table class="table table-bordered table-condensed table-hover mim-table-padding">
<thead>
<tr>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Location</strong>
</th>
<th class="col-lg-5 col-md-5 col-sm-5 col-xs-6 text-nowrap">
<strong>Phenotype</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Inheritance</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Phenotype<br />mapping key</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Phenotype<br />MIM number</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Gene/Locus</strong>
</th>
<th class="col-lg-1 col-md-1 col-sm-1 col-xs-1 text-nowrap">
<strong>Gene/Locus<br />MIM number</strong>
</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/25?start=-3&limit=10&highlight=25"> 1p36.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616126"> Immunodeficiency 38 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616126"> 616126 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147571"> ISG15 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147571"> 147571 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/31?start=-3&limit=10&highlight=31"> 1p36.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615593"> ?Immunodeficiency 16 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615593"> 615593 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600315"> TNFRSF4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600315"> 600315 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/114?start=-3&limit=10&highlight=114"> 1p36.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620282"> Immunodeficiency 109 with lymphoproliferation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620282"> 620282 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602250"> TNFRSF9 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602250"> 602250 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/128?start=-3&limit=10&highlight=128"> 1p36.22 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619281"> Immunodeficiency 14B, autosomal recessive </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619281"> 619281 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602839"> PIK3CD </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602839"> 602839 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/128?start=-3&limit=10&highlight=128"> 1p36.22 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615513"> Immunodeficiency 14A, autosomal dominant </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615513"> 615513 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602839"> PIK3CD </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602839"> 602839 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/397?start=-3&limit=10&highlight=397"> 1p35.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615758"> Immunodeficiency 22 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615758"> 615758 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/153390"> LCK </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/153390"> 153390 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/497?start=-3&limit=10&highlight=497"> 1p34.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615897"> Immunodeficiency 24 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615897"> 615897 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/123860"> CTPS1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/123860"> 123860 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/764?start=-3&limit=10&highlight=764"> 1p22.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616098"> ?Immunodeficiency 37 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616098"> 616098 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603517"> BCL10 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603517"> 603517 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/1110?start=-3&limit=10&highlight=1110"> 1q21.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616622"> Immunodeficiency 42 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616622"> 616622 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602943"> RORC </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602943"> 602943 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/1354?start=-3&limit=10&highlight=1354"> 1q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615707"> Immunodeficiency 20 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615707"> 615707 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146740"> FCGR3A </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146740"> 146740 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/1387?start=-3&limit=10&highlight=1387"> 1q24.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610163"> ?Immunodeficiency 25 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610163"> 610163 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186780"> CD247 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186780"> 186780 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/1492?start=-3&limit=10&highlight=1492"> 1q25.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620565"> Immunodeficiency 113 with autoimmunity and autoinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620565"> 620565 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604227"> ARPC5 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604227"> 604227 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/1502?start=-3&limit=10&highlight=1502"> 1q25.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618969"> Immunodeficiency 70 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618969"> 618969 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609209"> IVNS1ABP </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609209"> 609209 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/1/1542?start=-3&limit=10&highlight=1542"> 1q31.3-q32.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619924"> Immunodeficiency 105, severe combined </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619924"> 619924 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/151460"> PTPRC </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/151460"> 151460 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/277?start=-3&limit=10&highlight=277"> 2p16.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619652"> Immunodeficiency 92 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619652"> 619652 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/164910"> REL </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/164910"> 164910 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/446?start=-3&limit=10&highlight=446"> 2p11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608957"> Immunodeficiency 116 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608957"> 608957 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186910"> CD8A </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186910"> 186910 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/491?start=-3&limit=10&highlight=491"> 2q11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/269840"> Immunodeficiency 48 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/269840"> 269840 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/176947"> ZAP70 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/176947"> 176947 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/727?start=-3&limit=10&highlight=727"> 2q24.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619773"> Immunodeficiency 95 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619773"> 619773 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606951"> IFIH1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606951"> 606951 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/872?start=-3&limit=10&highlight=872"> 2q32.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614162"> Immunodeficiency 31C, chronic mucocutaneous candidiasis, autosomal dominant </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614162"> 614162 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600555"> STAT1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600555"> 600555 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/872?start=-3&limit=10&highlight=872"> 2q32.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614892"> Immunodeficiency 31A, mycobacteriosis, autosomal dominant </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614892"> 614892 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600555"> STAT1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600555"> 600555 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/872?start=-3&limit=10&highlight=872"> 2q32.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613796"> Immunodeficiency 31B, mycobacterial and viral infections, autosomal recessive </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613796"> 613796 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600555"> STAT1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600555"> 600555 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/933?start=-3&limit=10&highlight=933"> 2q33.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620901"> ?Immunodeficiency 123 with HPV-related verrucosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620901"> 620901 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186760"> CD28 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186760"> 186760 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/2/1028?start=-3&limit=10&highlight=1028"> 2q35 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611291"> Immunodeficiency 124, severe combined </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611291"> 611291 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611290"> NHEJ1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611290"> 611290 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/174?start=-3&limit=10&highlight=174"> 3p22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612260"> Immunodeficiency 68 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612260"> 612260 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602170"> MYD88 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602170"> 602170 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/652?start=-3&limit=10&highlight=652"> 3q21.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614172"> Immunodeficiency 21 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614172"> 614172 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/137295"> GATA2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/137295"> 137295 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/660?start=-3&limit=10&highlight=660"> 3q21.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620983"> ?Immunodeficiency 128 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620983"> 620983 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615525"> COPG1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615525"> 615525 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/3/991?start=-3&limit=10&highlight=991"> 3q29 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616740"> Immunodeficiency 46 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616740"> 616740 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/190010"> TFRC </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/190010"> 190010 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/167?start=-3&limit=10&highlight=167"> 4p14 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618307"> Immunodeficiency 129 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618307"> 618307 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602037"> RHOH </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602037"> 602037 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/458?start=-3&limit=10&highlight=458"> 4q24 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619126"> Immunodeficiency 75 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619126"> 619126 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612839"> TET2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612839"> 612839 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/4/723?start=-3&limit=10&highlight=723"> 4q35.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613002"> {Immunodeficiency 83, susceptibility to viral infections} </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>, <abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613002"> 613002 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603029"> TLR3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603029"> 603029 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/59?start=-3&limit=10&highlight=59"> 5p15.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619986"> {Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection} </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619986"> 619986 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615712"> OTULIN </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615712"> 615712 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/106?start=-3&limit=10&highlight=106"> 5p13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608971"> Immunodeficiency 104, severe combined </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608971"> 608971 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146661"> IL7R </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146661"> 146661 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/177?start=-3&limit=10&highlight=177"> 5q11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619750"> ?Immunodeficiency 94 with autoinflammation and dysmorphic facies </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619750"> 619750 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600694"> IL6ST </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600694"> 600694 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/218?start=-3&limit=10&highlight=218"> 5q13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616005"> Immunodeficiency 36 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616005"> 616005 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/171833"> PIK3R1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/171833"> 171833 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/440?start=-3&limit=10&highlight=440"> 5q31.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619705"> Immunodeficiency 93 and hypertrophic cardiomyopathy </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619705"> 619705 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610594"> FNIP1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610594"> 610594 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/449?start=-3&limit=10&highlight=449"> 5q31.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620668"> Immunodeficiency 117, mycobacteriosis, autosomal recessive </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620668"> 620668 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147575"> IRF1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147575"> 147575 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/721?start=-3&limit=10&highlight=721"> 5q33.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614890"> Immunodeficiency 29, mycobacteriosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614890"> 614890 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/161561"> IL12B </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/161561"> 161561 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/750?start=-3&limit=10&highlight=750"> 5q35.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616433"> Immunodeficiency 40 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616433"> 616433 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603122"> DOCK2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603122"> 603122 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/5/752?start=-3&limit=10&highlight=752"> 5q35.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619374"> Immunodeficiency 81 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619374"> 619374 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601603"> LCP2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601603"> 601603 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/7?start=-3&limit=10&highlight=7"> 6p25.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621097"> Immunodeficiency 131 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>, <abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621097"> 621097 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601900"> IRF4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601900"> 601900 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/20?start=-3&limit=10&highlight=20"> 6p25.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618108"> Immunodeficiency 57 with autoinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618108"> 618108 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603453"> RIPK1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603453"> 603453 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/311?start=-3&limit=10&highlight=311"> 6p21.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620977"> ?Immunodeficiency 127 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620977"> 620977 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/191160"> TNF </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/191160"> 191160 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/425?start=-3&limit=10&highlight=425"> 6p21.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619573"> Immunodeficiency 87 and autoimmunity </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619573"> 619573 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610094"> DEF6 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610094"> 610094 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/506?start=-3&limit=10&highlight=506"> 6p21.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620931"> Immunodeficiency 126 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620931"> 620931 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606817"> PTCRA </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606817"> 606817 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/675?start=-3&limit=10&highlight=675"> 6q14.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615816"> Immunodeficiency 23 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615816"> 615816 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/172100"> PGM3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/172100"> 172100 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/710?start=-3&limit=10&highlight=710"> 6q15 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618394"> Immunodeficiency 60 and autoimmunity </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618394"> 618394 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605394"> BACH2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605394"> 605394 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/893?start=-3&limit=10&highlight=893"> 6q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/209950"> Immunodeficiency 27A, mycobacteriosis, AR </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/209950"> 209950 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/107470"> IFNGR1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/107470"> 107470 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/6/893?start=-3&limit=10&highlight=893"> 6q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615978"> Immunodeficiency 27B, mycobacteriosis, AD </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615978"> 615978 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/107470"> IFNGR1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/107470"> 107470 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/33?start=-3&limit=10&highlight=33"> 7p22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617638"> Immunodeficiency 11B with atopic dermatitis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617638"> 617638 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607210"> CARD11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607210"> 607210 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/33?start=-3&limit=10&highlight=33"> 7p22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615206"> Immunodeficiency 11A </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615206"> 615206 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607210"> CARD11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607210"> 607210 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/461?start=-3&limit=10&highlight=461"> 7q22.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617718"> Immunodeficiency 71 with inflammatory disease and congenital thrombocytopenia </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617718"> 617718 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604223"> ARPC1B </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604223"> 604223 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/7/571?start=-3&limit=10&highlight=571"> 7q22.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619802"> Immunodeficiency 97 with autoinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619802"> 619802 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601232"> PIK3CG </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601232"> 601232 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/232?start=-3&limit=10&highlight=232"> 8p11.21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618204"> Immunodeficiency 15A </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618204"> 618204 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603258"> IKBKB </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603258"> 603258 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/232?start=-3&limit=10&highlight=232"> 8p11.21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615592"> Immunodeficiency 15B </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615592"> 615592 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603258"> IKBKB </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603258"> 603258 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/253?start=-3&limit=10&highlight=253"> 8q11.21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615966"> Immunodeficiency 26, with or without neurologic abnormalities </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615966"> 615966 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600899"> PRKDC </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600899"> 600899 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/254?start=-3&limit=10&highlight=254"> 8q11.21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609981"> Immunodeficiency 54 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609981"> 609981 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602638"> MCM4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602638"> 602638 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/8/358?start=-3&limit=10&highlight=358"> 8q21.13 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618309"> Immunodeficiency 130 with HPV-related verrucosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618309"> 618309 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146660"> IL7 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146660"> 146660 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/297?start=-3&limit=10&highlight=297"> 9q22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619381"> Immunodeficiency 82 with systemic inflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619381"> 619381 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600085"> SYK </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600085"> 600085 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/9/650?start=-3&limit=10&highlight=650"> 9q34.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/212050"> Immunodeficiency 103, susceptibility to fungal infection </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/212050"> 212050 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607212"> CARD9 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607212"> 607212 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/10/35?start=-3&limit=10&highlight=35"> 10p15.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606367"> Immunodeficiency 41 with lymphoproliferation and autoimmunity </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606367"> 606367 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147730"> IL2RA </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147730"> 147730 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/10/62?start=-3&limit=10&highlight=62"> 10p13 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619313"> Immunodeficiency 80 with or without cardiomyopathy </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619313"> 619313 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609357"> MCM10 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/609357"> 609357 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/33?start=-3&limit=10&highlight=33"> 11p15.5 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616345"> ?Immunodeficiency 39 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616345"> 616345 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605047"> IRF7 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605047"> 605047 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/103?start=-3&limit=10&highlight=103"> 11p15.4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612783"> Immunodeficiency 10 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612783"> 612783 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605921"> STIM1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605921"> 605921 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/415?start=-3&limit=10&highlight=415"> 11q12.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619223"> Immunodeficiency 77 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619223"> 619223 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610390"> MPEG1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610390"> 610390 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/703?start=-3&limit=10&highlight=703"> 11q13.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613759"> Immunodeficiency 90 with encephalopathy, functional hyposplenia, and hepatic dysfunction </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613759"> 613759 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602457"> FADD </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602457"> 602457 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/748?start=-3&limit=10&highlight=748"> 11q13.4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620869"> Immunodeficiency 122 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620869"> 620869 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611415"> POLD3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611415"> 611415 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/981?start=-3&limit=10&highlight=981"> 11q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615615"> Immunodeficiency 18 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615615"> 615615 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186830"> CD3E </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186830"> 186830 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/981?start=-3&limit=10&highlight=981"> 11q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615615"> Immunodeficiency 18, SCID variant </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615615"> 615615 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186830"> CD3E </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186830"> 186830 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/982?start=-3&limit=10&highlight=982"> 11q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615617"> Immunodeficiency 19, severe combined </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615617"> 615617 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186790"> CD3D </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186790"> 186790 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/983?start=-3&limit=10&highlight=983"> 11q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615607"> Immunodeficiency 17, CD3 gamma deficient </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615607"> 615607 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186740"> CD3G </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186740"> 186740 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/11/1002?start=-3&limit=10&highlight=1002"> 11q23.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/233600"> ?Immunodeficiency 59 and hypoglycemia </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/233600"> 233600 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601746"> HYOU1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601746"> 601746 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/70?start=-3&limit=10&highlight=70"> 12p13.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619238"> Immunodeficiency 79 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619238"> 619238 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186940"> CD4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186940"> 186940 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/300?start=-3&limit=10&highlight=300"> 12q12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607676"> Immunodeficiency 67 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607676"> 607676 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606883"> IRAK4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606883"> 606883 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/470?start=-3&limit=10&highlight=470"> 12q13.13-q13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618982"> Immunodeficiency 72 with autoinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618982"> 618982 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/141180"> NCKAP1L </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/141180"> 141180 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/512?start=-3&limit=10&highlight=512"> 12q13.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616636"> Immunodeficiency 44 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616636"> 616636 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600556"> STAT2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600556"> 600556 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/598?start=-3&limit=10&highlight=598"> 12q15 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618963"> ?Immunodeficiency 69, mycobacteriosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618963"> 618963 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147570"> IFNG </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147570"> 147570 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/825?start=-3&limit=10&highlight=825"> 12q24.13 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618042"> Immunodeficiency 100 with pulmonary alveolar proteinosis and hypogammaglobulinemia </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618042"> 618042 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/164350"> OAS1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/164350"> 164350 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/12/895?start=-3&limit=10&highlight=895"> 12q24.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612782"> Immunodeficiency 9 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612782"> 612782 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610277"> ORAI1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610277"> 610277 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/13/294?start=-3&limit=10&highlight=294"> 13q33.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619220"> Immunodeficiency 78 with autoimmunity and developmental delay </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619220"> 619220 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/190470"> TPP2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/190470"> 190470 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/61?start=-3&limit=10&highlight=61"> 14q11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615387"> Immunodeficiency 7, TCR-alpha/beta deficient </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615387"> 615387 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186880"> TRAC </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/186880"> 186880 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/79?start=-3&limit=10&highlight=79"> 14q11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/260570"> ?Immunodeficiency 108 with autoinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/260570"> 260570 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600749"> CEBPE </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600749"> 600749 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/116?start=-3&limit=10&highlight=116"> 14q12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620632"> Immunodeficiency 115 with autoinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620632"> 620632 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612487"> RNF31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/612487"> 612487 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/117?start=-3&limit=10&highlight=117"> 14q12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618648"> Immunodeficiency 65, susceptibility to viral infections </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618648"> 618648 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147574"> IRF9 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147574"> 147574 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/515?start=-3&limit=10&highlight=515"> 14q32.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617237"> Immunodeficiency 49, severe combined </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617237"> 617237 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606558"> BCL11B </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606558"> 606558 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/567?start=-3&limit=10&highlight=567"> 14q32.32 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621096"> Immunodeficiency 132B </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/621096"> 621096 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601896"> TRAF3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601896"> 601896 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/14/567?start=-3&limit=10&highlight=567"> 14q32.32 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614849"> Immunodeficiency 132A </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614849"> 614849 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601896"> TRAF3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601896"> 601896 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/15/85?start=-3&limit=10&highlight=85"> 15q14 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618534"> Immunodeficiency 64 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618534"> 618534 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603962"> RASGRP1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/603962"> 603962 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/15/170?start=-3&limit=10&highlight=170"> 15q21.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/241600"> Immunodeficiency 43 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/241600"> 241600 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/109700"> B2M </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/109700"> 109700 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/15/209?start=-3&limit=10&highlight=209"> 15q21.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619549"> Immunodeficiency 86, mycobacteriosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619549"> 619549 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608238"> SPPL2A </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608238"> 608238 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/295?start=-3&limit=10&highlight=295"> 16p12.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615207"> Immunodeficiency 56 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615207"> 615207 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605383"> IL21R </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605383"> 605383 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/321?start=-3&limit=10&highlight=321"> 16p11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617514"> Immunodeficiency 52 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617514"> 617514 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602354"> LAT </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602354"> 602354 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/348?start=-3&limit=10&highlight=348"> 16p11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615401"> Immunodeficiency 8 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615401"> 615401 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605000"> CORO1A </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605000"> 605000 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/553?start=-3&limit=10&highlight=553"> 16q22.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618131"> Immunodeficiency 58 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618131"> 618131 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610859"> CARMIL2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610859"> 610859 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/566?start=-3&limit=10&highlight=566"> 16q22.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620807"> Immunodeficiency 121 with autoinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620807"> 620807 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/176847"> PSMB10 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/176847"> 176847 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/711?start=-3&limit=10&highlight=711"> 16q24.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614893"> Immunodeficiency 32A, mycobacteriosis, autosomal dominant </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614893"> 614893 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601565"> IRF8 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601565"> 601565 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/16/711?start=-3&limit=10&highlight=711"> 16q24.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/226990"> Immunodeficiency 32B, monocyte and dendritic cell deficiency, autosomal recessive </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/226990"> 226990 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601565"> IRF8 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601565"> 601565 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/340?start=-3&limit=10&highlight=340"> 17q11.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615518"> ?Immunodeficiency 13 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615518"> 615518 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604011"> UNC119 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604011"> 604011 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/494?start=-3&limit=10&highlight=494"> 17q12-q21.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619437"> ?Immunodeficiency 84 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619437"> 619437 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606221"> IKZF3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606221"> 606221 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/658?start=-3&limit=10&highlight=658"> 17q21.31 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620449"> Immunodeficiency 112 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620449"> 620449 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604655"> MAP3K14 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604655"> 604655 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/17/678?start=-3&limit=10&highlight=678"> 17q21.32 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619630"> ?Immunodeficiency 88 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619630"> 619630 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604895"> TBX21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604895"> 604895 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/18/212?start=-3&limit=10&highlight=212"> 18q21.32 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615468"> Immunodeficiency 12 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/615468"> 615468 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604860"> MALT1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604860"> 604860 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/145?start=-3&limit=10&highlight=145"> 19p13.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620331"> Hatipoglu immunodeficiency syndrome </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620331"> 620331 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608258"> DPP9 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608258"> 608258 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/270?start=-3&limit=10&highlight=270"> 19p13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611521"> Immunodeficiency 35 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611521"> 611521 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/176941"> TYK2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/176941"> 176941 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/444?start=-3&limit=10&highlight=444"> 19p13.11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619164"> Immunodeficiency 76 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619164"> 619164 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613437"> FCHO1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613437"> 613437 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/451?start=-3&limit=10&highlight=451"> 19p13.11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614891"> Immunodeficiency 30 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614891"> 614891 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601604"> IL12RB1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601604"> 601604 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/743?start=-3&limit=10&highlight=743"> 19q13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618459"> ?Immunodeficiency 62 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618459"> 618459 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601855"> ARHGEF1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/601855"> 601855 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/808?start=-3&limit=10&highlight=808"> 19q13.32 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617585"> ?Immunodeficiency 53 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617585"> 617585 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604758"> RELB </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604758"> 604758 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/888?start=-3&limit=10&highlight=888"> 19q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619774"> Immunodeficiency 96 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619774"> 619774 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/126391"> LIG1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/126391"> 126391 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/947?start=-3&limit=10&highlight=947"> 19q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620926"> ?Immunodeficiency 125 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620926"> 620926 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600007"> FLT3LG </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600007"> 600007 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/19/981?start=-3&limit=10&highlight=981"> 19q13.33 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620836"> Immunodeficiency 120 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620836"> 620836 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/174761"> POLD1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/174761"> 174761 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/124?start=-3&limit=10&highlight=124"> 20p11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619872"> ?Immunodeficiency 101 (varicella zoster virus-specific) </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619872"> 619872 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617455"> POLR3F </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617455"> 617455 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/169?start=-3&limit=10&highlight=169"> 20p11.21 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617827"> Immunodeficiency 55 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/617827"> 617827 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610608"> GINS1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/610608"> 610608 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/271?start=-3&limit=10&highlight=271"> 20q11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619846"> ?Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619846"> 619846 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611537"> CTNNBL1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/611537"> 611537 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/321?start=-3&limit=10&highlight=321"> 20q13.12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614868"> T-cell immunodeficiency, recurrent infections, autoimmunity, and cardiac malformations </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614868"> 614868 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604965"> STK4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604965"> 604965 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/20/373?start=-3&limit=10&highlight=373"> 20q13.13 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619644"> Immunodeficiency 91 and hyperinflammation </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619644"> 619644 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618931"> ZNFX1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618931"> 618931 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/21/66?start=-3&limit=10&highlight=66"> 21q22.11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616669"> Immunodeficiency 45 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/616669"> 616669 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602376"> IFNAR2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602376"> 602376 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/21/68?start=-3&limit=10&highlight=68"> 21q22.11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619935"> Immunodeficiency 106, susceptibility to viral infections </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619935"> 619935 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/107450"> IFNAR1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/107450"> 107450 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/21/69?start=-3&limit=10&highlight=69"> 21q22.11 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614889"> Immunodeficiency 28, mycobacteriosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/614889"> 614889 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147569"> IFNGR2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/147569"> 147569 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/21/155?start=-3&limit=10&highlight=155"> 21q22.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620825"> ?Immunodeficiency 119 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620825"> 620825 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605717"> ICOSLG </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605717"> 605717 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/21/172?start=-3&limit=10&highlight=172"> 21q22.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620603"> Immunodeficiency 114, folate-responsive </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/620603"> 620603 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600424"> SLC19A1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/600424"> 600424 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/9?start=-3&limit=10&highlight=9"> 22q11.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613953"> Immunodeficiency 51 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/613953"> 613953 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605461"> IL17RA </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/605461"> 605461 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/210?start=-3&limit=10&highlight=210"> 22q12.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619510"> ?Immunodeficiency 85 and autoimmunity </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619510"> 619510 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604700"> TOM1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/604700"> 604700 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/236?start=-3&limit=10&highlight=236"> 22q12.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618495"> Immunodeficiency 63 with lymphoproliferation and autoimmunity </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618495"> 618495 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146710"> IL2RB </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/146710"> 146710 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/243?start=-3&limit=10&highlight=243"> 22q13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618986"> Immunodeficiency 73B with defective neutrophil chemotaxis and lymphopenia </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618986"> 618986 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602049"> RAC2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602049"> 602049 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/243?start=-3&limit=10&highlight=243"> 22q13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608203"> Immunodeficiency 73A with defective neutrophil chemotaxix and leukocytosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/608203"> 608203 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602049"> RAC2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602049"> 602049 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/243?start=-3&limit=10&highlight=243"> 22q13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618987"> ?Immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618987"> 618987 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602049"> RAC2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/602049"> 602049 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/247?start=-3&limit=10&highlight=247"> 22q13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619632"> ?Immunodeficiency 89 and autoimmunity </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/619632"> 619632 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607209"> CARD10 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/607209"> 607209 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/22/308?start=-3&limit=10&highlight=308"> 22q13.1-q13.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618847"> ?Immunodeficiency 66 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/618847"> 618847 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606078"> MKL1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/606078"> 606078 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/62?start=-3&limit=10&highlight=62"> Xp22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301051"> Immunodeficiency 74, COVID19-related, X-linked </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301051"> 301051 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300365"> TLR7 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300365"> 300365 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/63?start=-3&limit=10&highlight=63"> Xp22.2 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301078"> Immunodeficiency 98 with autoinflammation, X-linked </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="Somatic mosaicism">SMo</abbr>, <abbr class="mim-tip-hint" title="X-linked">XL</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301078"> 301078 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300366"> TLR8 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300366"> 300366 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/107?start=-3&limit=10&highlight=107"> Xp22.12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300310"> ?Immunodeficiency 61 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300310"> 300310 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300374"> SH3KBP1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300374"> 300374 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/158?start=-3&limit=10&highlight=158"> Xp21.1-p11.4 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300645"> Immunodeficiency 34, mycobacteriosis, X-linked </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300645"> 300645 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300481"> CYBB </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300481"> 300481 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/254?start=-3&limit=10&highlight=254"> Xp11.23 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301000"> Wiskott-Aldrich syndrome </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301000"> 301000 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300392"> WAS </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300392"> 300392 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/374?start=-3&limit=10&highlight=374"> Xq12 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300988"> Immunodeficiency 50 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300988"> 300988 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/309845"> MSN </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/309845"> 309845 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/404?start=-3&limit=10&highlight=404"> Xq13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/312863"> Combined immunodeficiency, X-linked, moderate </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/312863"> 312863 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308380"> IL2RG </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308380"> 308380 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/404?start=-3&limit=10&highlight=404"> Xq13.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300400"> Severe combined immunodeficiency, X-linked </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300400"> 300400 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308380"> IL2RG </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308380"> 308380 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/501?start=-3&limit=10&highlight=501"> Xq22.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300755"> Agammaglobulinemia, X-linked 1 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300755"> 300755 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300300"> BTK </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300300"> 300300 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/630?start=-3&limit=10&highlight=630"> Xq24 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301115"> Immunodeficiency 118, mycobacteriosis </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301115"> 301115 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300587"> MCTS1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300587"> 300587 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/656?start=-3&limit=10&highlight=656"> Xq25 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308240"> Lymphoproliferative syndrome, X-linked, 1 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308240"> 308240 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300490"> SH2D1A </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300490"> 300490 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/671?start=-3&limit=10&highlight=671"> Xq26.1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301082"> Immunodeficiency 102 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/301082"> 301082 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300441"> SASH3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300441"> 300441 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/725?start=-3&limit=10&highlight=725"> Xq26.3 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308230"> Immunodeficiency, X-linked, with hyper-IgM </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/308230"> 308230 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300386"> TNFSF5 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300386"> 300386 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/863?start=-3&limit=10&highlight=863"> Xq28 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300972"> Immunodeficiency 47 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300972"> 300972 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300197"> ATP6AP1 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300197"> 300197 </a>
</span>
</td>
</tr>
<tr>
<td>
<span class="mim-font">
<a href="/geneMap/X/872?start=-3&limit=10&highlight=872"> Xq28 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300636"> Immunodeficiency 33 </a>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="X-linked recessive">XLR</abbr>
</span>
</td>
<td>
<span class="mim-font">
<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300636"> 300636 </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300248"> IKBKG </a>
</span>
</td>
<td>
<span class="mim-font">
<a href="/entry/300248"> 300248 </a>
</span>
</td>
</tr>
</tbody>
</table>
</div>
<div class="text-right small">
<a href="#mimPhenotypicSeriesFold" data-toggle="collapse">&#9650;&nbsp;Close</a>
</div>
</div>
</div>
</div>
<div>
<br />
</div>
<div>
<a id="text" class="mim-anchor"></a>
<h4 href="#mimTextFold" id="mimTextToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimTextToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<span class="mim-tip-floating" qtip_title="<strong>Looking For More References?</strong>" qtip_text="Click the 'reference plus' icon &lt;span class='glyphicon glyphicon-plus-sign'&gt;&lt;/span&gt at the end of each OMIM text paragraph to see more references related to the content of the preceding paragraph.">
<strong>TEXT</strong>
</span>
</span>
</h4>
<div id="mimTextFold" class="collapse in ">
<span class="mim-text-font">
<p>A number sign (#) is used with this entry because X-linked combined immunodeficiency (CIDX) is caused by mutation in the gene encoding the gamma subunit of the interleukin-2 receptor (IL2RG; <a href="/entry/308380">308380</a>).</p><p>X-linked severe combined immunodeficiency (SCIDX1; <a href="/entry/300400">300400</a>) is caused by mutation in the same gene.</p>
</span>
<div>
<br />
</div>
</div>
<div>
<a id="clinicalFeatures" class="mim-anchor"></a>
<h4 href="#mimClinicalFeaturesFold" id="mimClinicalFeaturesToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimClinicalFeaturesToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<strong>Clinical Features</strong>
</span>
</h4>
</div>
<div id="mimClinicalFeaturesFold" class="collapse in mimTextToggleFold">
<span class="mim-text-font">
<p><a href="#1" class="mim-tip-reference" title="Brooks, E. G., Schmalstieg, F. C., Wirt, D. P., Rosenblatt, H. M., Adkins, L. T., Lookingbill, D. P., Rudloff, H. E., Rakusan, T. A., Goldman, A. S. &lt;strong&gt;A novel X-linked combined immunodeficiency disease.&lt;/strong&gt; J. Clin. Invest. 86: 1623-1631, 1990.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/2243135/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;2243135&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1172/JCI114884&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="2243135">Brooks et al. (1990)</a> described a family in which 5 living males had a form of combined immunodeficiency inherited in an X-linked recessive pattern. The disorder was different from the previously described forms of X-linked immunodeficiency and specifically different from SCIDX1. The age of the 5 affected males ranged from 2.5 to 34 years. The most prominent clinical abnormalities were paucity of lymphoid tissue; recurrent sinusitis, otitis media, bronchitis, and pneumonia; severe varicella; and chronic papillomavirus infections. Immunologic analysis showed normal concentrations of serum immunoglobulins, but restricted formation of IgG antibodies to immunogens; normal numbers of B cells and NK cells but decreased numbers of CD4+ and CD8+ T lymphocytes; diminished proliferative responses of blood T cells to allogeneic cells, mitogens, and antigens; and decreased production of interleukin-2 (IL2; <a href="/entry/146680">146680</a>) by mitogen-stimulated blood lymphocytes. The pedigree showed that 2 affected males, both deceased, had produced children; all 3 of the children, 1 male and 2 females, were unaffected, but 1 female had an affected son, thus proving herself to be a carrier. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2243135" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#2" class="mim-tip-reference" title="Schmalstieg, F. C., Leonard, W. J., Noguchi, M., Berg, M., Rudloff, H. E., Denney, R. M., Dave, S. K., Brooks, E. G., Goldman, A. S. &lt;strong&gt;Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.&lt;/strong&gt; J. Clin. Invest. 95: 1169-1173, 1995.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/7883965/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;7883965&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1172/JCI117765&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="7883965">Schmalstieg et al. (1995)</a> showed that X-chromosome inactivation in obligate carriers of CIDX is nonrandom in T and B lymphocytes, as in SCIDX1. X-chromosome inactivation in polymorphic nuclear leukocytes was variable. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7883965" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#3" class="mim-tip-reference" title="Sharfe, N., Shahar, M., Roifman, C. M. &lt;strong&gt;An interleukin-2 receptor gamma chain mutation with normal thymus morphology.&lt;/strong&gt; J. Clin. Invest. 100: 3036-3043, 1997.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/9399950/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;9399950&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1172/JCI119858&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="9399950">Sharfe et al. (1997)</a> reported a child who was normal until the age of 9 months when he developed progressive respiratory symptoms caused by Pneumocystis carinii, which was treated successfully with trimethoprim-sulfamethazole. Physical examination was normal, with normal numbers of peripheral T and B cells, normal cervical lymph nodes, and a normal thymus gland viewed by ultrasonography and biopsy. Although immunoglobulin subtypes were normal, the patient had defective humoral immunity. T cells showed an unusual lack of response to exogenous IL2 The patient received a matched unrelated bone marrow transplantation and was doing well at the time of report. A maternal male cousin had previously been diagnosed with an unusual combined immunodeficiency with normal numbers of both B and T peripheral lymphocytes and normal levels of immunoglobulins and specific antibodies. That patient died at the age of 2 years after a mismatched bone marrow transplant following lectin T-cell depletion. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=9399950" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
</span>
<div>
<br />
</div>
</div>
<div>
<a id="molecularGenetics" class="mim-anchor"></a>
<h4 href="#mimMolecularGeneticsFold" id="mimMolecularGeneticsToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span id="mimMolecularGeneticsToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<span class="mim-font">
<strong>Molecular Genetics</strong>
</span>
</h4>
</div>
<div id="mimMolecularGeneticsFold" class="collapse in mimTextToggleFold">
<span class="mim-text-font">
<p>In 3 related males with CIDX, <a href="#2" class="mim-tip-reference" title="Schmalstieg, F. C., Leonard, W. J., Noguchi, M., Berg, M., Rudloff, H. E., Denney, R. M., Dave, S. K., Brooks, E. G., Goldman, A. S. &lt;strong&gt;Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.&lt;/strong&gt; J. Clin. Invest. 95: 1169-1173, 1995.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/7883965/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;7883965&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1172/JCI117765&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="7883965">Schmalstieg et al. (1995)</a> identified a mutation in the IL2RG gene (<a href="/entry/308380#0008">308380.0008</a>). A normal brother did not have the mutation. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7883965" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a child with CIDX, <a href="#3" class="mim-tip-reference" title="Sharfe, N., Shahar, M., Roifman, C. M. &lt;strong&gt;An interleukin-2 receptor gamma chain mutation with normal thymus morphology.&lt;/strong&gt; J. Clin. Invest. 100: 3036-3043, 1997.[PubMed: &lt;a href=&quot;https://pubmed.ncbi.nlm.nih.gov/9399950/&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;name&#x27;: &#x27;PubMed&#x27;, &#x27;domain&#x27;: &#x27;pubmed.ncbi.nlm.nih.gov&#x27;})&quot;&gt;9399950&lt;/a&gt;] [&lt;a href=&quot;https://doi.org/10.1172/JCI119858&quot; target=&quot;_blank&quot; onclick=&quot;gtag(&#x27;event&#x27;, &#x27;mim_outbound&#x27;, {&#x27;destination&#x27;: &#x27;Publisher&#x27;})&quot;&gt;Full Text&lt;/a&gt;]" pmid="9399950">Sharfe et al. (1997)</a> identified a mutation in the IL2RG gene (<a href="/entry/308380#0012">308380.0012</a>). The authors noted that mutations in the IL2RG gene can result in a spectrum of immunologic phenotypes. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=9399950" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
</span>
<div>
<br />
</div>
</div>
</div>
<div>
<a id="references"class="mim-anchor"></a>
<h4 href="#mimReferencesFold" id="mimReferencesToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
<span class="mim-font">
<span id="mimReferencesToggleTriangle" class="small mimTextToggleTriangle">&#9660;</span>
<strong>REFERENCES</strong>
</span>
</h4>
<div>
<p />
</div>
<div id="mimReferencesFold" class="collapse in mimTextToggleFold">
<ol>
<li>
<a id="1" class="mim-anchor"></a>
<a id="Brooks1990" class="mim-anchor"></a>
<div class="">
<p class="mim-text-font">
Brooks, E. G., Schmalstieg, F. C., Wirt, D. P., Rosenblatt, H. M., Adkins, L. T., Lookingbill, D. P., Rudloff, H. E., Rakusan, T. A., Goldman, A. S.
<strong>A novel X-linked combined immunodeficiency disease.</strong>
J. Clin. Invest. 86: 1623-1631, 1990.
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2243135/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2243135</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2243135" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
[<a href="https://doi.org/10.1172/JCI114884" target="_blank">Full Text</a>]
</p>
</div>
</li>
<li>
<a id="2" class="mim-anchor"></a>
<a id="Schmalstieg1995" class="mim-anchor"></a>
<div class="">
<p class="mim-text-font">
Schmalstieg, F. C., Leonard, W. J., Noguchi, M., Berg, M., Rudloff, H. E., Denney, R. M., Dave, S. K., Brooks, E. G., Goldman, A. S.
<strong>Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.</strong>
J. Clin. Invest. 95: 1169-1173, 1995.
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7883965/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7883965</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7883965" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
[<a href="https://doi.org/10.1172/JCI117765" target="_blank">Full Text</a>]
</p>
</div>
</li>
<li>
<a id="3" class="mim-anchor"></a>
<a id="Sharfe1997" class="mim-anchor"></a>
<div class="">
<p class="mim-text-font">
Sharfe, N., Shahar, M., Roifman, C. M.
<strong>An interleukin-2 receptor gamma chain mutation with normal thymus morphology.</strong>
J. Clin. Invest. 100: 3036-3043, 1997.
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/9399950/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">9399950</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=9399950" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
[<a href="https://doi.org/10.1172/JCI119858" target="_blank">Full Text</a>]
</p>
</div>
</li>
</ol>
<div>
<br />
</div>
</div>
</div>
<div>
<a id="contributors" class="mim-anchor"></a>
<div class="row">
<div class="col-lg-2 col-md-2 col-sm-4 col-xs-4">
<span class="mim-text-font">
Contributors:
</span>
</div>
<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
<span class="mim-text-font">
Cassandra L. Kniffin - reorganized : 10/28/2004
</span>
</div>
</div>
</div>
<div>
<a id="creationDate" class="mim-anchor"></a>
<div class="row">
<div class="col-lg-2 col-md-2 col-sm-4 col-xs-4">
<span class="text-nowrap mim-text-font">
Creation Date:
</span>
</div>
<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
<span class="mim-text-font">
Victor A. McKusick : 11/16/1990
</span>
</div>
</div>
</div>
<div>
<a id="editHistory" class="mim-anchor"></a>
<div class="row">
<div class="col-lg-2 col-md-2 col-sm-4 col-xs-4">
<span class="text-nowrap mim-text-font">
<a href="#mimCollapseEditHistory" role="button" data-toggle="collapse"> Edit History: </a>
</span>
</div>
<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
<span class="mim-text-font">
carol : 10/28/2004
</span>
</div>
</div>
<div class="row collapse" id="mimCollapseEditHistory">
<div class="col-lg-offset-2 col-md-offset-2 col-sm-offset-4 col-xs-offset-4 col-lg-6 col-md-6 col-sm-6 col-xs-6">
<span class="mim-text-font">
terry : 10/28/2004<br>ckniffin : 10/20/2004<br>carol : 2/17/2000<br>alopez : 12/2/1998<br>dkim : 7/21/1998<br>mark : 4/4/1995<br>mimadm : 2/28/1994<br>supermim : 3/17/1992<br>carol : 6/5/1991<br>carol : 11/30/1990<br>carol : 11/16/1990
</span>
</div>
</div>
</div>
</div>
</div>
</div>
<div class="container visible-print-block">
<div class="row">
<div class="col-md-8 col-md-offset-1">
<div>
<div>
<h3>
<span class="mim-font">
<strong>#</strong> 312863
</span>
</h3>
</div>
<div>
<h3>
<span class="mim-font">
COMBINED IMMUNODEFICIENCY, X-LINKED; CIDX
</span>
</h3>
</div>
<div>
<br />
</div>
<div>
<div >
<p>
<span class="mim-font">
<em>Alternative titles; symbols</em>
</span>
</p>
</div>
<div>
<h4>
<span class="mim-font">
XCID<br />
IMMUNODEFICIENCY 6; IMD6
</span>
</h4>
</div>
</div>
<div>
<br />
</div>
</div>
<div>
<h4>
<span class="mim-font">
<strong>Phenotype-Gene Relationships</strong>
</span>
</h4>
<div>
<table class="table table-bordered table-condensed small mim-table-padding">
<thead>
<tr class="active">
<th>
Location
</th>
<th>
Phenotype
</th>
<th>
Phenotype <br /> MIM number
</th>
<th>
Inheritance
</th>
<th>
Phenotype <br /> mapping key
</th>
<th>
Gene/Locus
</th>
<th>
Gene/Locus <br /> MIM number
</th>
</tr>
</thead>
<tbody>
<tr>
<td>
<span class="mim-font">
Xq13.1
</span>
</td>
<td>
<span class="mim-font">
Combined immunodeficiency, X-linked, moderate
</span>
</td>
<td>
<span class="mim-font">
312863
</span>
</td>
<td>
<span class="mim-font">
X-linked recessive
</span>
</td>
<td>
<span class="mim-font">
3
</span>
</td>
<td>
<span class="mim-font">
IL2RG
</span>
</td>
<td>
<span class="mim-font">
308380
</span>
</td>
</tr>
</tbody>
</table>
</div>
</div>
<div>
<br />
</div>
<div>
<h4>
<span class="mim-font">
<strong>TEXT</strong>
</span>
</h4>
<span class="mim-text-font">
<p>A number sign (#) is used with this entry because X-linked combined immunodeficiency (CIDX) is caused by mutation in the gene encoding the gamma subunit of the interleukin-2 receptor (IL2RG; 308380).</p><p>X-linked severe combined immunodeficiency (SCIDX1; 300400) is caused by mutation in the same gene.</p>
</span>
<div>
<br />
</div>
<div>
<h4>
<span class="mim-font">
<strong>Clinical Features</strong>
</span>
</h4>
</div>
<span class="mim-text-font">
<p>Brooks et al. (1990) described a family in which 5 living males had a form of combined immunodeficiency inherited in an X-linked recessive pattern. The disorder was different from the previously described forms of X-linked immunodeficiency and specifically different from SCIDX1. The age of the 5 affected males ranged from 2.5 to 34 years. The most prominent clinical abnormalities were paucity of lymphoid tissue; recurrent sinusitis, otitis media, bronchitis, and pneumonia; severe varicella; and chronic papillomavirus infections. Immunologic analysis showed normal concentrations of serum immunoglobulins, but restricted formation of IgG antibodies to immunogens; normal numbers of B cells and NK cells but decreased numbers of CD4+ and CD8+ T lymphocytes; diminished proliferative responses of blood T cells to allogeneic cells, mitogens, and antigens; and decreased production of interleukin-2 (IL2; 146680) by mitogen-stimulated blood lymphocytes. The pedigree showed that 2 affected males, both deceased, had produced children; all 3 of the children, 1 male and 2 females, were unaffected, but 1 female had an affected son, thus proving herself to be a carrier. </p><p>Schmalstieg et al. (1995) showed that X-chromosome inactivation in obligate carriers of CIDX is nonrandom in T and B lymphocytes, as in SCIDX1. X-chromosome inactivation in polymorphic nuclear leukocytes was variable. </p><p>Sharfe et al. (1997) reported a child who was normal until the age of 9 months when he developed progressive respiratory symptoms caused by Pneumocystis carinii, which was treated successfully with trimethoprim-sulfamethazole. Physical examination was normal, with normal numbers of peripheral T and B cells, normal cervical lymph nodes, and a normal thymus gland viewed by ultrasonography and biopsy. Although immunoglobulin subtypes were normal, the patient had defective humoral immunity. T cells showed an unusual lack of response to exogenous IL2 The patient received a matched unrelated bone marrow transplantation and was doing well at the time of report. A maternal male cousin had previously been diagnosed with an unusual combined immunodeficiency with normal numbers of both B and T peripheral lymphocytes and normal levels of immunoglobulins and specific antibodies. That patient died at the age of 2 years after a mismatched bone marrow transplant following lectin T-cell depletion. </p>
</span>
<div>
<br />
</div>
<div>
<h4>
<span class="mim-font">
<strong>Molecular Genetics</strong>
</span>
</h4>
</div>
<span class="mim-text-font">
<p>In 3 related males with CIDX, Schmalstieg et al. (1995) identified a mutation in the IL2RG gene (308380.0008). A normal brother did not have the mutation. </p><p>In a child with CIDX, Sharfe et al. (1997) identified a mutation in the IL2RG gene (308380.0012). The authors noted that mutations in the IL2RG gene can result in a spectrum of immunologic phenotypes. </p>
</span>
<div>
<br />
</div>
</div>
<div>
<h4>
<span class="mim-font">
<strong>REFERENCES</strong>
</span>
</h4>
<div>
<p />
</div>
<div>
<ol>
<li>
<p class="mim-text-font">
Brooks, E. G., Schmalstieg, F. C., Wirt, D. P., Rosenblatt, H. M., Adkins, L. T., Lookingbill, D. P., Rudloff, H. E., Rakusan, T. A., Goldman, A. S.
<strong>A novel X-linked combined immunodeficiency disease.</strong>
J. Clin. Invest. 86: 1623-1631, 1990.
[PubMed: 2243135]
[Full Text: https://doi.org/10.1172/JCI114884]
</p>
</li>
<li>
<p class="mim-text-font">
Schmalstieg, F. C., Leonard, W. J., Noguchi, M., Berg, M., Rudloff, H. E., Denney, R. M., Dave, S. K., Brooks, E. G., Goldman, A. S.
<strong>Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency.</strong>
J. Clin. Invest. 95: 1169-1173, 1995.
[PubMed: 7883965]
[Full Text: https://doi.org/10.1172/JCI117765]
</p>
</li>
<li>
<p class="mim-text-font">
Sharfe, N., Shahar, M., Roifman, C. M.
<strong>An interleukin-2 receptor gamma chain mutation with normal thymus morphology.</strong>
J. Clin. Invest. 100: 3036-3043, 1997.
[PubMed: 9399950]
[Full Text: https://doi.org/10.1172/JCI119858]
</p>
</li>
</ol>
<div>
<br />
</div>
</div>
</div>
<div>
<div class="row">
<div class="col-lg-1 col-md-1 col-sm-2 col-xs-2">
<span class="text-nowrap mim-text-font">
Contributors:
</span>
</div>
<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
<span class="mim-text-font">
Cassandra L. Kniffin - reorganized : 10/28/2004
</span>
</div>
</div>
</div>
<div>
<br />
</div>
<div>
<div class="row">
<div class="col-lg-1 col-md-1 col-sm-2 col-xs-2">
<span class="text-nowrap mim-text-font">
Creation Date:
</span>
</div>
<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
<span class="mim-text-font">
Victor A. McKusick : 11/16/1990
</span>
</div>
</div>
</div>
<div>
<br />
</div>
<div>
<div class="row">
<div class="col-lg-1 col-md-1 col-sm-2 col-xs-2">
<span class="text-nowrap mim-text-font">
Edit History:
</span>
</div>
<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
<span class="mim-text-font">
carol : 10/28/2004<br>terry : 10/28/2004<br>ckniffin : 10/20/2004<br>carol : 2/17/2000<br>alopez : 12/2/1998<br>dkim : 7/21/1998<br>mark : 4/4/1995<br>mimadm : 2/28/1994<br>supermim : 3/17/1992<br>carol : 6/5/1991<br>carol : 11/30/1990<br>carol : 11/16/1990
</span>
</div>
</div>
</div>
<div>
<br />
</div>
</div>
</div>
</div>
</div>
<div id="mimFooter">
<div class="container ">
<div class="row">
<br />
<br />
</div>
</div>
<div class="hidden-print mim-footer">
<div class="container">
<div class="row">
<p />
</div>
<div class="row text-center small">
NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers,
and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal
medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
<br />
OMIM<sup>&reg;</sup> and Online Mendelian Inheritance in Man<sup>&reg;</sup> are registered trademarks of the Johns Hopkins University.
<br />
Copyright<sup>&reg;</sup> 1966-2025 Johns Hopkins University.
</div>
</div>
</div>
<div class="visible-print-block mim-footer" style="position: relative;">
<div class="container">
<div class="row">
<p />
</div>
<div class="row text-center small">
NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers,
and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal
medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
<br />
OMIM<sup>&reg;</sup> and Online Mendelian Inheritance in Man<sup>&reg;</sup> are registered trademarks of the Johns Hopkins University.
<br />
Copyright<sup>&reg;</sup> 1966-2025 Johns Hopkins University.
<br />
Printed: March 15, 2025
</div>
</div>
</div>
</div>
<div class="modal fade" id="mimDonationPopupModal" tabindex="-1" role="dialog" aria-labelledby="mimDonationPopupModalTitle">
<div class="modal-dialog" role="document">
<div class="modal-content">
<div class="modal-header">
<button type="button" id="mimDonationPopupCancel" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">&times;</span></button>
<h4 class="modal-title" id="mimDonationPopupModalTitle">
OMIM Donation:
</h4>
</div>
<div class="modal-body">
<div class="row">
<div class="col-lg-offset-1 col-md-offset-1 col-sm-offset-1 col-xs-offset-1 col-lg-10 col-md-10 col-sm-10 col-xs-10">
<p>
Dear OMIM User,
</p>
</div>
</div>
<div class="row">
<div class="col-lg-offset-1 col-md-offset-1 col-sm-offset-1 col-xs-offset-1 col-lg-10 col-md-10 col-sm-10 col-xs-10">
<p>
To ensure long-term funding for the OMIM project, we have diversified
our revenue stream. We are determined to keep this website freely
accessible. Unfortunately, it is not free to produce. Expert curators
review the literature and organize it to facilitate your work. Over 90%
of the OMIM's operating expenses go to salary support for MD and PhD
science writers and biocurators. Please join your colleagues by making a
donation now and again in the future. Donations are an important
component of our efforts to ensure long-term funding to provide you the
information that you need at your fingertips.
</p>
</div>
</div>
<div class="row">
<div class="col-lg-offset-1 col-md-offset-1 col-sm-offset-1 col-xs-offset-1 col-lg-10 col-md-10 col-sm-10 col-xs-10">
<p>
Thank you in advance for your generous support, <br />
Ada Hamosh, MD, MPH <br />
Scientific Director, OMIM <br />
</p>
</div>
</div>
</div>
<div class="modal-footer">
<button type="button" id="mimDonationPopupDonate" class="btn btn-success btn-block" data-dismiss="modal"> Donate To OMIM! </button>
</div>
</div>
</div>
</div>
</div>
</body>
</html>