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<title>
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Entry
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- #258870 - GYRATE ATROPHY OF CHOROID AND RETINA; GACR
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- OMIM
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<span class="h4">#258870</span>
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<br />
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<strong>Table of Contents</strong>
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<a href="#title"><strong>Title</strong></a>
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<a href="#phenotypeMap"><strong>Phenotype-Gene Relationships</strong></a>
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<a href="/clinicalSynopsis/258870"><strong>Clinical Synopsis</strong></a>
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<a href="#text"><strong>Text</strong></a>
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<a href="#description">Description</a>
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<a href="#clinicalFeatures">Clinical Features</a>
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<a href="#inheritance">Inheritance</a>
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<a href="#clinicalManagement">Clinical Management</a>
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<a href="#populationGenetics">Population Genetics</a>
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<a href="#mapping">Mapping</a>
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<a href="#molecularGenetics">Molecular Genetics</a>
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<a href="#animalModel">Animal Model</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#history">History</a>
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<a href="#seeAlso"><strong>See Also</strong></a>
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<li role="presentation">
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<a href="#references"><strong>References</strong></a>
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<a href="#contributors"><strong>Contributors</strong></a>
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<a href="#creationDate"><strong>Creation Date</strong></a>
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<li role="presentation">
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<a href="#editHistory"><strong>Edit History</strong></a>
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<div style="display: table-cell;">External Links</div>
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<div><a href="https://hprd.org/summary?hprd_id=02021&isoform_id=02021_1&isoform_name=Isoform_1" class="mim-tip-hint" title="The Human Protein Reference Database; manually extracted and visually depicted information on human proteins." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HPRD', 'domain': 'hprd.org'})">HPRD</a></div>
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<div><a href="https://clinicaltrials.gov/search?cond=(GYRATE ATROPHY OF CHOROID RETINA) OR (OAT)" class="mim-tip-hint" title="Clinical Trials" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Clinical Trials', 'domain': 'clinicaltrials.gov'})">Clinical Trials</a></div>
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<div><a href="https://www.orpha.net/consor/cgi-bin/ClinicalLabs_Search_Simple.php?lng=EN&LnkId=3349&Typ=Pat" class="mim-tip-hint" title="A list of European laboratories that offer genetic testing." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'EuroGentest', 'domain': 'orpha.net'})">EuroGentest</a></div>
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<div><a href="https://www.diseaseinfosearch.org/x/5411" class="mim-tip-hint" title="Network of disease-specific advocacy organizations, universities, private companies, government agencies, and public policy organizations." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Genetic Alliance', 'domain': 'diseaseinfosearch.org'})">Genetic Alliance</a></div>
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<div><a href="https://medlineplus.gov/genetics/condition/gyrate-atrophy-of-the-choroid-and-retina" class="mim-tip-hint" title="Consumer-friendly information about the effects of genetic variation on human health." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MedlinePlus Genetics', 'domain': 'medlineplus.gov'})">MedlinePlus Genetics</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=258870[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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<div><a href="https://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=414" class="mim-tip-hint" title="European reference portal for information on rare diseases and orphan drugs." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'OrphaNet', 'domain': 'orpha.net'})">OrphaNet</a></div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimAnimalModels">
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<span class="panel-title">
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<span class="small">
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<a href="#mimAnimalModelsLinksFold" id="mimAnimalModelsLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimAnimalModelsLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Animal Models</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimAnimalModelsLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.alliancegenome.org/disease/DOID:1415" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
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<div><a href="http://www.informatics.jax.org/disease/258870" class="mim-tip-hint" title="Phenotypes, alleles, and disease models from Mouse Genome Informatics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Phenotype', 'domain': 'informatics.jax.org'})">MGI Mouse Phenotype</a></div>
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<div><a href="https://omia.org/OMIA001774/" class="mim-tip-hint" title="Online Mendelian Inheritance in Animals (OMIA) is a database of genes, inherited disorders and traits in 191 animal species (other than human and mouse.)" target="_blank">OMIA</a></div>
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<div><a href="https://wormbase.org/resources/disease/DOID:1415" class="mim-tip-hint" title="Database of the biology and genome of Caenorhabditis elegans and related nematodes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Disease Ontology', 'domain': 'wormbase.org'})">Wormbase Disease Ontology</a></div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimCellLines">
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<span class="panel-title">
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<span class="small">
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<div style="display: table-row">
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<div id="mimCellLinesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Cell Lines</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimCellLinesLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://catalog.coriell.org/Search?q=OmimNum:258870" class="definition" title="Coriell Cell Repositories; cell cultures and DNA derived from cell cultures." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'CCR', 'domain': 'ccr.coriell.org'})">Coriell</a></div>
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</div>
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</div>
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</div>
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</div>
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</div>
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</div>
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<span>
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<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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</span>
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</span>
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</div>
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<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
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<div>
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<a id="title" class="mim-anchor"></a>
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<div>
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<a id="number" class="mim-anchor"></a>
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<div class="text-right">
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<a href="#" class="mim-tip-icd" qtip_title="<strong>ICD+</strong>" qtip_text="
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<strong>SNOMEDCT:</strong> 276426004, 314467007, 33985005<br />
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<strong>ORPHA:</strong> 414<br />
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<strong>DO:</strong> 1415<br />
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">ICD+</a>
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</div>
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<div>
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<span class="h3">
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<span class="mim-font mim-tip-hint" title="Phenotype description, molecular basis known">
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<span class="text-danger"><strong>#</strong></span>
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258870
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</span>
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</span>
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</div>
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</div>
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<div>
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<a id="preferredTitle" class="mim-anchor"></a>
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<h3>
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<span class="mim-font">
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GYRATE ATROPHY OF CHOROID AND RETINA; GACR
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</span>
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</h3>
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</div>
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<div>
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<br />
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</div>
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<div>
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<a id="alternativeTitles" class="mim-anchor"></a>
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<div>
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<p>
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<span class="mim-font">
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<em>Alternative titles; symbols</em>
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</span>
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</p>
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</div>
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<div>
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<h4>
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<span class="mim-font">
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HYPERORNITHINEMIA WITH GYRATE ATROPHY OF CHOROID AND RETINA; HOGA<br />
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GYRATE ATROPHY<br />
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ORNITHINE AMINOTRANSFERASE DEFICIENCY<br />
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OAT DEFICIENCY<br />
|
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ORNITHINE KETO ACID AMINOTRANSFERASE DEFICIENCY<br />
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OKT DEFICIENCY<br />
|
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ORNITHINE-DELTA-AMINOTRANSFERASE DEFICIENCY
|
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</span>
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</h4>
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</div>
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</div>
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<div>
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<br />
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</div>
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</div>
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<div>
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<a id="phenotypeMap" class="mim-anchor"></a>
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<h4>
|
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<span class="mim-font">
|
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<strong>Phenotype-Gene Relationships</strong>
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</span>
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</h4>
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<div>
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<table class="table table-bordered table-condensed table-hover small mim-table-padding">
|
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<thead>
|
|
<tr class="active">
|
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<th>
|
|
Location
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</th>
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<th>
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Phenotype
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</th>
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<th>
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Phenotype <br /> MIM number
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</th>
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<th>
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Inheritance
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</th>
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<th>
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Phenotype <br /> mapping key
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</th>
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<th>
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Gene/Locus
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</th>
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<th>
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Gene/Locus <br /> MIM number
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</th>
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</tr>
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</thead>
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<tbody>
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<tr>
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<td>
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<span class="mim-font">
|
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<a href="/geneMap/10/637?start=-3&limit=10&highlight=637">
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10q26.13
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</a>
|
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</span>
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</td>
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<td>
|
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<span class="mim-font">
|
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Gyrate atrophy of choroid and retina with or without ornithinemia
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</span>
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</td>
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<td>
|
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<span class="mim-font">
|
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<a href="/entry/258870"> 258870 </a>
|
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</span>
|
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</td>
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<td>
|
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="Autosomal recessive">AR</abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
|
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OAT
|
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</span>
|
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</td>
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<td>
|
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<span class="mim-font">
|
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<a href="/entry/613349"> 613349 </a>
|
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</span>
|
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</td>
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</tr>
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</tbody>
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</table>
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</div>
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</div>
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<div>
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<div class="btn-group ">
|
|
<a href="/clinicalSynopsis/258870" class="btn btn-warning" role="button"> Clinical Synopsis </a>
|
|
<button type="button" id="mimPhenotypicSeriesToggle" class="btn btn-warning dropdown-toggle mimSingletonFoldToggle" data-toggle="collapse" href="#mimClinicalSynopsisFold" onclick="ga('send', 'event', 'Unfurl', 'ClinicalSynopsis', 'omim.org')">
|
|
<span class="caret"></span>
|
|
<span class="sr-only">Toggle Dropdown</span>
|
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</button>
|
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</div>
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<div class="btn-group">
|
|
<button type="button" class="btn btn-success dropdown-toggle" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
|
|
PheneGene Graphics <span class="caret"></span>
|
|
</button>
|
|
<ul class="dropdown-menu" style="width: 17em;">
|
|
<li><a href="/graph/linear/258870" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Linear'})"> Linear </a></li>
|
|
<li><a href="/graph/radial/258870" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Radial'})"> Radial </a></li>
|
|
</ul>
|
|
</div>
|
|
<span class="glyphicon glyphicon-question-sign mim-tip-hint" title="OMIM PheneGene graphics depict relationships between phenotypes, groups of related phenotypes (Phenotypic Series), and genes.<br /><a href='/static/omim/pdf/OMIM_Graphics.pdf' target='_blank'>A quick reference overview and guide (PDF)</a>"></span>
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<div>
|
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<p />
|
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</div>
|
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<div id="mimClinicalSynopsisFold" class="well well-sm collapse mimSingletonToggleFold">
|
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<div class="small" style="margin: 5px">
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<div>
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<div>
|
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<span class="h5 mim-font">
|
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<strong> INHERITANCE </strong>
|
|
</span>
|
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</div>
|
|
<div style="margin-left: 2em;">
|
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<div>
|
|
<span class="mim-font">
|
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|
|
- Autosomal recessive <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/258211005" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">258211005</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0441748&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0441748</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000007" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000007</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000007" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000007</a>]</span><br />
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</span>
|
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</div>
|
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</div>
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</div>
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<div>
|
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<div>
|
|
<span class="h5 mim-font">
|
|
<strong> HEAD & NECK </strong>
|
|
</span>
|
|
</div>
|
|
<div style="margin-left: 2em;">
|
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<div>
|
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<div>
|
|
<span class="h5 mim-font">
|
|
<em> Eyes </em>
|
|
</span>
|
|
</div>
|
|
<div style="margin-left: 2em;">
|
|
<span class="mim-font">
|
|
|
|
- Progressive chorioretinal degeneration <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850241&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850241</a>]</span><br /> -
|
|
Myopia (onset in first decade) <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850242&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850242</a>]</span> <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/57190000" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">57190000</a>]</span> <span class="mim-feature-ids hidden">[ICD10CM: <a href="https://purl.bioontology.org/ontology/ICD10CM/H52.1" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">H52.1</a>]</span> <span class="mim-feature-ids hidden">[ICD9CM: <a href="https://purl.bioontology.org/ontology/ICD9CM/367.1" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">367.1</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000545" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000545</a>]</span><br /> -
|
|
Night blindness (onset in first decade) <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850243&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850243</a>]</span> <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/65194006" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">65194006</a>]</span> <span class="mim-feature-ids hidden">[ICD10CM: <a href="https://purl.bioontology.org/ontology/ICD10CM/H53.6" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">H53.6</a>, <a href="https://purl.bioontology.org/ontology/ICD10CM/H53.60" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">H53.60</a>]</span> <span class="mim-feature-ids hidden">[ICD9CM: <a href="https://purl.bioontology.org/ontology/ICD9CM/368.6" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">368.6</a>, <a href="https://purl.bioontology.org/ontology/ICD9CM/368.60" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">368.60</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000662" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000662</a>]</span><br /> -
|
|
Progressive loss of peripheral vision (onset in first decade) <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850244&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850244</a>]</span><br /> -
|
|
Blindness (onset in fourth or fifth decade) <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850245&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850245</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000618" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000618</a>]</span><br /> -
|
|
Posterior subcapsular cataracts (onset in second or third decade) <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C3806487&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C3806487</a>]</span> <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/315353005" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">315353005</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0007787" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0007787</a>]</span><br />
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|
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</span>
|
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</div>
|
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</div>
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</div>
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</div>
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<div>
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<div>
|
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<span class="h5 mim-font">
|
|
<strong> MUSCLE, SOFT TISSUES </strong>
|
|
</span>
|
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</div>
|
|
<div style="margin-left: 2em;">
|
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|
<div>
|
|
<span class="mim-font">
|
|
|
|
- Mild proximal muscle weakness (<10% of patients) <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1843869&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1843869</a>]</span> <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/249939004" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">249939004</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0003701" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0003701</a>]</span><br /> -
|
|
Tubular aggregates in type 2 skeletal muscle fibers <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850253&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850253</a>]</span><br /> -
|
|
Abnormal EMG <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/274523007" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">274523007</a>]</span> <span class="mim-feature-ids hidden">[ICD10CM: <a href="https://purl.bioontology.org/ontology/ICD10CM/R94.131" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD10CM\', \'domain\': \'bioontology.org\'})">R94.131</a>]</span> <span class="mim-feature-ids hidden">[ICD9CM: <a href="https://purl.bioontology.org/ontology/ICD9CM/794.17" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'ICD9CM\', \'domain\': \'bioontology.org\'})">794.17</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0476403&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0476403</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0003457" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0003457</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0003457" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0003457</a>]</span><br />
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</span>
|
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</div>
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</div>
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</div>
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- Elevated plasma ornithine (~10-fold) <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850247&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850247</a>]</span><br /> -
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Elevated urinary ornithine, lysine, arginine <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850250&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850250</a>]</span><br /> -
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Decreased plasma lysine, glutamic acid, and glutamine <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C1850251&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1850251</a>]</span><br />
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- Caused by mutation in the ornithine aminotransferase gene (OAT, <a href="/entry/613349#0001">613349.0001</a>)<br />
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<p>A number sign (#) is used with this entry because gyrate atrophy of the choroid and retina (GACR) is caused by homozygous or compound heterozygous mutation in the OAT gene (<a href="/entry/613349">613349</a>) on chromosome 10q26.</p>
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<p>Gyrate atrophy of the choroid and retina (GACR) due to deficiency of ornithine aminotransferase is clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence (summary by <a href="#19" class="mim-tip-reference" title="Peltola, K. E., Jaaskelainen, S., Heinonen, O. J., Falck, B., Nanto-Salonen, K., Heinanen, K., Simell, O. <strong>Peripheral nervous system in gyrate atrophy of the choroid and retina with hyperornithinemia.</strong> Neurology 59: 735-740, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12221166/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12221166</a>] [<a href="https://doi.org/10.1212/wnl.59.5.735" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12221166">Peltola et al., 2002</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12221166" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>See <a href="/entry/238970">238970</a> for another hyperornithinemia syndrome.</p>
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<p>Hyperornithinemia presumably due to deficiency of ornithine ketoacid aminotransferase was found in 9 patients with gyrate atrophy of the choroid and retina (<a href="#23" class="mim-tip-reference" title="Simell, O., Takki, K. <strong>Raised plasma ornithine and gyrate atrophy of the choroid and retina.</strong> Lancet 301: 1031-1033, 1973. Note: Originally Volume I.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4122112/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4122112</a>] [<a href="https://doi.org/10.1016/s0140-6736(73)90667-3" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4122112">Simell and Takki, 1973</a>). The clinical history of gyrate atrophy is usually night blindness that begins in late childhood, accompanied by sharply demarcated circular areas of chorioretinal atrophy. During the second and third decades the areas of atrophy enlarge. Ornithine levels were 10 to 20 times higher than normal in plasma, urine, spinal fluid, and aqueous humor. No consistent clinical abnormality other than the ocular one was found. Hyperammonemia was not found in the fasting state or after meals or stress testing. All the patients' parents were from the same geographic area of Finland. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4122112" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Most patients with gyrate atrophy have posterior subcapsular cataracts by the end of the second decade (<a href="#12" class="mim-tip-reference" title="Kaiser-Kupfer, M., Kuwabara, T., Uga, S., Takki, K., Valle, D. <strong>Cataracts in gyrate atrophy: clinical and morphologic studies.</strong> Invest. Ophthal. Vis. Sci. 24: 432-436, 1983.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6832916/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6832916</a>]" pmid="6832916">Kaiser-Kupfer et al., 1983</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6832916" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#27" class="mim-tip-reference" title="Sipila, I., Simell, O., Rapola, J., Sainio, K., Tuuteri, L. <strong>Gyrate atrophy of the choroid and retina with hyperornithinemia: tubular aggregates and type 2 fiber atrophy in muscle.</strong> Neurology 29: 996-1005, 1979.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/572946/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">572946</a>] [<a href="https://doi.org/10.1212/wnl.29.7.996" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="572946">Sipila et al. (1979)</a> studied 21 patients with gyrate atrophy with hyperornithinemia and found that type II muscle fibers were almost universally atrophic and had tubular aggregates. Despite the changes in type II fibers, the patients usually had no muscle symptoms, although some showed impaired performance when speed or acute strength was required. The disease progresses to almost complete loss of type II fibers, but the progression of muscle changes is slower than that of ocular pathology. <a href="#34" class="mim-tip-reference" title="Valtonen, M., Nanto-Salonen, K., Heinanen, K., Alanen, A., Kalimo, H., Simell, O. <strong>Skeletal muscle of patients with gyrate atrophy of the choroid and retina and hyperornithinaemia in ultralow-field magnetic resonance imaging and computed tomography.</strong> J. Inherit. Metab. Dis. 19: 729-734, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8982944/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8982944</a>] [<a href="https://doi.org/10.1007/BF01799162" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8982944">Valtonen et al. (1996)</a> found type II muscle fiber atrophy in all 7 patients with gyrate atrophy studied by muscle biopsy and found tubular aggregates in 6 of the 7 patients. CT and MRI studies showed changes in the thigh muscles in all patients. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=8982944+572946" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>It has been suggested that changes in skeletal muscle, as well as the ocular changes, may be mediated by hyperornithinemia-induced deficiency of high-energy creatine phosphate. Abnormal brain MRI and EEG studies are found in another disorder of creatine metabolism, guanidinoacetate methyltransferase deficiency (<a href="/entry/612736">612736</a>); for this reason, <a href="#35" class="mim-tip-reference" title="Valtonen, M., Nanto-Salonen, K., Jaaskelainen, S., Heinanen, K., Alanen, A., Heinonen, O. J., Lundbom, N., Erkintalo, M., Simell, O. <strong>Central nervous system involvement in gyrate atrophy of the choroid and retina with hyperornithinaemia.</strong> J. Inherit. Metab. Dis. 22: 855-866, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10604138/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10604138</a>] [<a href="https://doi.org/10.1023/a:1005602405349" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10604138">Valtonen et al. (1999)</a> investigated CNS involvement in gyrate atrophy, which seems to be associated with a milder degree of phosphocreatine deficiency. They compared 23 untreated gyrate atrophy patients with age-matched healthy controls, and with 9 patients who had received creatine or creatine precursor supplementation daily for several years. The MRI or EEG findings of the patients on creatine supplementation did not differ from those of the untreated group. Brain MRI revealed degenerative lesions in the white matter in 50% of the gyrate atrophy patients, and 70% of the patients had premature atrophic changes, with a striking increase in the number of Virchow spaces. Of the patients whose EEG was recorded, 58% had abnormal slow background activity, focal lesions, or high-amplitude beta rhythm. The EEG findings were not associated with the MRI changes or with the age or sex of the patients. <a href="#35" class="mim-tip-reference" title="Valtonen, M., Nanto-Salonen, K., Jaaskelainen, S., Heinanen, K., Alanen, A., Heinonen, O. J., Lundbom, N., Erkintalo, M., Simell, O. <strong>Central nervous system involvement in gyrate atrophy of the choroid and retina with hyperornithinaemia.</strong> J. Inherit. Metab. Dis. 22: 855-866, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10604138/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10604138</a>] [<a href="https://doi.org/10.1023/a:1005602405349" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10604138">Valtonen et al. (1999)</a> concluded that early degenerative and atrophic brain changes and abnormal EEG are features of gyrate atrophy, in addition to the well-characterized eye and muscle manifestations. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10604138" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#29" class="mim-tip-reference" title="Stoppoloni, G., Prisco, F., Santinelli, R., Tolone, C. <strong>Hyperornithinemia and gyrate atrophy of choroid and retina: report of a case.</strong> Helv. Paediat. Acta 33: 429-433, 1978.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/711502/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">711502</a>]" pmid="711502">Stoppoloni et al. (1978)</a> reported a patient with gyrate atrophy at age 3 years and 9 months who also had mild mental retardation, delayed language development, and speech defects. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=711502" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#31" class="mim-tip-reference" title="Valle, D., Kaiser-Kupfer, M. I., Del Valle, L. A. <strong>Gyrate atrophy of the choroid and retina: deficiency of ornithine aminotransferase in transformed lymphocytes.</strong> Proc. Nat. Acad. Sci. 74: 5159-5161, 1977.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/270753/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">270753</a>] [<a href="https://doi.org/10.1073/pnas.74.11.5159" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="270753">Valle et al. (1977)</a> demonstrated deficiency of ornithine-delta-aminotransferase, a pyridoxal-dependent enzyme, in transformed lymphocytes. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=270753" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Some cases of OAT deficiency are B6-responsive. <a href="#38" class="mim-tip-reference" title="Wirtz, M. K., Kennaway, N. G., Weleber, R. G. <strong>Heterogeneity and complementation analysis of fibroblasts from vitamin B6 responsive and non-responsive patients with gyrate atrophy of the choroid and retina.</strong> J. Inherit. Metab. Dis. 8: 71-74, 1985.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3939534/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3939534</a>] [<a href="https://doi.org/10.1007/BF01801668" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3939534">Wirtz et al. (1985)</a> found no complementation when fibroblasts from four B6-responsive and three B6-nonresponsive patients were fused. This suggests that the 2 forms are allelic. B6-responsive patients had higher activity of OAT in cell homogenates and greater incorporation of radioactivity from (14)C-ornithine into protein in cultured cells in situ than did B6-unresponsive patients. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3939534" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#22" class="mim-tip-reference" title="Shih, V. E., Mandell, R., Berson, E. L. <strong>Pyridoxine effects on ornithine ketoacid transaminase activity in fibroblasts from carriers of two forms of gyrate atrophy of the choroid and retina.</strong> Am. J. Hum. Genet. 43: 929-933, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3195590/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3195590</a>]" pmid="3195590">Shih et al. (1988)</a> studied fibroblasts from heterozygotes for the pyridoxine-responsive variant and from heterozygotes for the pyridoxine-nonresponsive variant. Both contain intermediate levels of OAT activity. The 2 variants could be distinguished, however, by the in vitro responsiveness of OAT activity to pyridoxal phosphate (PLP) stimulation. The ratios of OAT with no PLP added were lowest for controls, intermediate for pyridoxine-nonresponsive heterozygotes, and highest for pyridoxine-responsive heterozygotes. <a href="#13" class="mim-tip-reference" title="Kennaway, N. G., Stankova, L., Wirtz, M. K., Weleber, R. G. <strong>Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6.</strong> Am. J. Hum. Genet. 44: 344-352, 1989.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2916580/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2916580</a>]" pmid="2916580">Kennaway et al. (1989)</a> studied the mutant enzyme in 9 patients with gyrate atrophy of the choroid and retina by use of a radiochemical assay to measure the Km for PLP in fibroblast mitochondria and the heat stability of OAT at 45 degrees in the presence and absence of PLP. The apparent Km for PLP was lower in nonresponsive patients than in patients responsive to pyridoxine. In 7 patients studied, the apparent Km for ornithine was normal. The patient with the mildest clinical disease, responsive to pyridoxine, had the most stable enzyme, but also the highest Km for PLP. OAT protein was clearly detectable by Western blot analysis of mitochondrial proteins in the pyridoxine-responsive patients and in 2 of 5 nonresponders, but was low or undetectable in the 3 other patients. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=2916580+3195590" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#2" class="mim-tip-reference" title="Barrett, D. J., Bateman, J. B., Sparkes, R. S., Mohandas, T., Klisak, I., Inana, G. <strong>Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp11.2.</strong> Invest. Ophthal. Vis. Sci. 28: 1037-1042, 1987.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3596985/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3596985</a>]" pmid="3596985">Barrett et al. (1987)</a> reviewed 80 reported cases of gyrate atrophy and concluded that the pattern of inheritance was always consistent with the autosomal recessive hypothesis. Forty-four, or 55%, were female. No significant quantitative differences in OAT deficiency had been found in cultured fibroblasts and lymphocytes from male and female patients. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3596985" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>The main source of ornithine is arginine in dietary protein, and restriction of arginine in the diet appears to have therapeutic value (<a href="#11" class="mim-tip-reference" title="Kaiser-Kupfer, M. I., de Monasterio, F. M., Valle, D., Walser, M., Brusilow, S. <strong>Gyrate atrophy of the choroid and retina: improved visual function following reduction of plasma ornithine by diet.</strong> Science 210: 1128-1131, 1980.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7444439/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7444439</a>] [<a href="https://doi.org/10.1126/science.7444439" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7444439">Kaiser-Kupfer et al., 1980</a>; <a href="#33" class="mim-tip-reference" title="Valle, D., Walser, M., Brusilow, S. W. <strong>Gyrate atrophy of the choroid and retina: amino acid metabolism and correction of hyperornithinemia with an arginine-deficient diet.</strong> J. Clin. Invest. 65: 371-378, 1980.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7356686/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7356686</a>] [<a href="https://doi.org/10.1172/JCI109680" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7356686">Valle et al., 1980</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?term=7444439+7356686" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#10" class="mim-tip-reference" title="Kaiser-Kupfer, M. I., Caruso, R. C., Valle, D. <strong>Gyrate atrophy of the choroid and retina: further experience with long-term reduction of ornithine levels in children.</strong> Arch. Ophthal. 120: 146-153, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11831916/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11831916</a>] [<a href="https://doi.org/10.1001/archopht.120.2.146" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11831916">Kaiser-Kupfer et al. (2002)</a> reported the results of 16 to 17 years of arginine-restricted diet on 2 sib pairs. In both families, the younger sib in each pair, who was prescribed the diet at an earlier age, demonstrated a slower progression of lesions compared with the older sib. They concluded that, if started at an early age, long-term substantial reduction of plasma ornithine levels might appreciably slow the progression of the chorioretinal lesions and, to a lesser extent, the progressive loss of retinal function in patients with gyrate atrophy. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11831916" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#1" class="mim-tip-reference" title="Balfoort, B. M., Buijs, M. J. N., ten Asbroek, A. L. M. A., Bergen, A. A. B., Boon, C. J. F., Ferreira, E. A., Houtkooper, R. H., Wagenmakers, M. A. E. M., Wanders, R. J.A., Waterham, H. R., Timmer, C., van Karnebeek, C. D., Brands, M. M. <strong>A review of treatment modalities in gyrate atrophy of the choroid and retina (GACR).</strong> Molec. Genet. Metab. 134: 96-116, 2021.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/34340878/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">34340878</a>] [<a href="https://doi.org/10.1016/j.ymgme.2021.07.010" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="34340878">Balfoort et al. (2021)</a> performed a literature review to assess treatment modalities in gyrate atrophy and found that a protein-restricted diet, pyridoxine supplementation, and/or lysine supplementation were effective in lowering plasma ornithine levels. Responsiveness to pyridoxine was associated with specific mutations in the OAT gene. However, <a href="#1" class="mim-tip-reference" title="Balfoort, B. M., Buijs, M. J. N., ten Asbroek, A. L. M. A., Bergen, A. A. B., Boon, C. J. F., Ferreira, E. A., Houtkooper, R. H., Wagenmakers, M. A. E. M., Wanders, R. J.A., Waterham, H. R., Timmer, C., van Karnebeek, C. D., Brands, M. M. <strong>A review of treatment modalities in gyrate atrophy of the choroid and retina (GACR).</strong> Molec. Genet. Metab. 134: 96-116, 2021.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/34340878/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">34340878</a>] [<a href="https://doi.org/10.1016/j.ymgme.2021.07.010" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="34340878">Balfoort et al. (2021)</a> concluded that a lack of uniform clinical outcome measures made it difficult to determine clinical effectiveness of these ornithine-lowering interventions. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=34340878" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><strong><em>Gene Therapy</em></strong></p><p>
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<a href="#4" class="mim-tip-reference" title="Caruso, R. C., Nussenblatt, R. B., Csaky, K. G., Valle, D., Kaiser-Kupfer, M. I. <strong>Assessment of visual function in patients with gyrate atrophy who are considered candidates for gene replacement.</strong> Arch. Ophthal. 119: 667-669, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11346393/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11346393</a>] [<a href="https://doi.org/10.1001/archopht.119.5.667" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11346393">Caruso et al. (2001)</a> examined the course of change in visual function outcome variables in 5 patients with gyrate atrophy in anticipation of a gene replacement therapy clinical trial. In the 4 to 6 years during which each patient was followed, median visual field half-lives were 17.0 years (static perimetry) and 11.4 years (kinetic perimetry). Median electroretinogram half-lives were 16.0 years (maximal response) and 10.7 years (flicker response). The authors concluded that the decline in visual function outcome variables was frequently slow. Thus, a long-term clinical trial would be required to assess the efficacy of the intervention in the preservation of visual function in gyrate atrophy patients. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11346393" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#32" class="mim-tip-reference" title="Valle, D., Simell, O. <strong>The hyperornithinemias. In: Scriver, C. R.; Beaudet, A. L.; Sly, W. S.; Valle, D. (eds.): The Metabolic and Molecular Bases of Inherited Disease. Vol. II. (8th ed.)</strong> New York: McGraw-Hill (pub.) 2001. Pp. 1857-1895."None>Valle and Simell (2001)</a> stated that approximately 200 biochemically confirmed cases of GACR are known. The incidence is highest in Finland, with an estimated frequency of about 1 in 50,000 individuals and an estimated frequency for heterozygotes of 1 in 110 individuals.</p>
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<p><a href="#20" class="mim-tip-reference" title="Ramesh, V., Benoit, L. A., Crawford, P., Harvey, P. T., Shows, T. B., Shih, V. E., Gusella, J. F. <strong>The ornithine aminotransferase (OAT) locus: analysis of RFLPs in gyrate atrophy.</strong> Am. J. Hum. Genet. 42: 365-372, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2893548/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2893548</a>]" pmid="2893548">Ramesh et al. (1988)</a> demonstrated that the OAT locus segregated concordantly with gyrate atrophy in 1 pedigree and showed significant disequilibrium with gyrate atrophy, thus providing genetic evidence that a defect in the OAT structural gene on chromosome 10 is the cause of the disorder. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2893548" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>In patients with gyrate atrophy of the choroid and retina, <a href="#17" class="mim-tip-reference" title="Mitchell, G. A., Brody, L. C., Looney, J., Steel, G., Suchanek, M., Dowling, C., Der Kaloustian, V., Kaiser-Kupfer, M., Valle, D. <strong>An initiator codon mutation in ornithine-delta-aminotransferase causing gyrate atrophy of the choroid and retina.</strong> J. Clin. Invest. 81: 630-633, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3339136/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3339136</a>] [<a href="https://doi.org/10.1172/JCI113365" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3339136">Mitchell et al. (1988)</a> identified a mutation in the OAT gene (<a href="/entry/613349#0001">613349.0001</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3339136" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#3" class="mim-tip-reference" title="Brody, L. C., Mitchell, G. A., Obie, C., Michaud, J., Steel, G., Fontaine, G., Robert, M.-F., Sipila, I., Kaiser-Kupfer, M., Valle, D. <strong>Ornithine delta-aminotransferase mutations in gyrate atrophy: allelic heterogeneity and functional consequences.</strong> J. Biol. Chem. 267: 3302-3307, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1737786/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1737786</a>]" pmid="1737786">Brody et al. (1992)</a> discovered and characterized the molecular defect in 21 newly recognized OAT alleles. They determined the consequences of these and 3 previously described mutations on OAT mRNA, antigen, and enzyme activity in cultured fibroblasts. In 20 of the 24 alleles, normal amounts of normal-sized OAT mRNA were produced. By contrast, only 2 of the 24 had normal amounts of OAT antigen. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1737786" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#36" class="mim-tip-reference" title="Wang, T., Lawler, A. M., Steel, G., Sipila, I., Milam, A. H., Valle, D. <strong>Mice lacking ornithine-delta-amino-transferase have paradoxical neonatal hypoornithinaemia and retinal degeneration.</strong> Nature Genet. 11: 185-190, 1995.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7550347/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7550347</a>] [<a href="https://doi.org/10.1038/ng1095-185" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7550347">Wang et al. (1995)</a> found that Oat-deficient mice produced by gene targeting exhibit neonatal hypoornithinemia and lethality, rescuable by short-term arginine supplementation. Postweaning, these mice developed hyperornithinemia similar to human gyrate atrophy patients. Studies in 1 human gyrate atrophy infant also showed transient hypoornithinemia. Thus, the authors concluded that the OAT reaction plays opposite roles in neonatal and adult mammals. Over several months, Oat-deficient mice develop a retinal degeneration with involvement of photoreceptors and pigment epithelium. Oat-deficient mice appear to be an authentic model of human gyrate atrophy. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7550347" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>To determine whether chronic, systemic reduction of ornithine can prevent gyrate atrophy, <a href="#37" class="mim-tip-reference" title="Wang, T., Steel, G., Milam, A. H., Valle, D. <strong>Correction of ornithine accumulation prevents retinal degeneration in a mouse model of gyrate atrophy of the choroid and retina.</strong> Proc. Nat. Acad. Sci. 97: 1224-1229, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10655512/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10655512</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=10655512[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1073/pnas.97.3.1224" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10655512">Wang et al. (2000)</a> used an arginine-restricted diet to maintain long-term reduction of ornithine in the mouse model of Oat deficiency produced by gene targeting. They evaluated the mice over a 12-month period by measurement of plasma amino acids, electroretinograms, and retinal histology and ultrastructural studies. They found that an arginine-restricted diet substantially reduced plasma ornithine levels and completely prevented retinal degeneration in Oat -/- mice. This result indicated that ornithine accumulation is a necessary factor in the pathophysiology of the retinal degeneration in gyrate atrophy and that restoration of OAT activity in retina is not required for effective treatment of gyrate atrophy. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10655512" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>Fuchs atrophia gyrata chorioideae et retinae is a rare disorder characterized by slowly progressive atrophy of the choroid, pigment epithelium, and retina. <a href="#5" class="mim-tip-reference" title="Francois, J., Barbier, F., De Rouck, A. <strong>Les conducteurs du gene de l'atrophia gyrata chorioideae et retinae de fuchs (anomalie d'Alder).</strong> Acta Genet. Med. Gemellol. 9: 74-91, 1960.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/13824432/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">13824432</a>] [<a href="https://doi.org/10.1017/s1120962300018448" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="13824432">Francois et al. (1960)</a> described a patient in which leukocyte inclusions were present not only in the patient but also in both parents, who were consanguineous, and in other members of the family through 4 generations. The authors originally suggested that the leukocyte anomaly was a heterozygous expression of the gene which in the homozygous state produces Fuchs atrophy. In a later publication, however, <a href="#6" class="mim-tip-reference" title="Francois, J., Barbier, F., De Rouck, A. <strong>A propos des conducteurs du gene de l'atrophia gyrata chorioideae et retinae de fuchs.</strong> Acta Genet. Med. Gemellol. 15: 34-35, 1966.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5930170/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5930170</a>] [<a href="https://doi.org/10.1017/s1120962300013573" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="5930170">Francois et al. (1966)</a> reported failure to find the Alder anomaly in 9 patients with the eye anomaly. The authors concluded that there is no true gyrate atrophy independent of ornithinemia. Presumed cases may represent simulating conditions. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=5930170+13824432" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<a href="#Francois1961" class="mim-tip-reference" title="Francois, J. <strong>Heredity in Ophthalmology.</strong> St. Louis: C. V. Mosby (pub.) 1961.">Francois (1961)</a>; <a href="#Francois1962" class="mim-tip-reference" title="Francois, J. <strong>Progress in ophthalmic genetics. In: Steinberg, A. G.; Bearn, A. G. (eds.): Progress in Medical Genetics. Vol. II.</strong> New York: Grune and Stratton 1962. Pp. 331-365.">Francois (1962)</a>; <a href="#Fukuda1983" class="mim-tip-reference" title="Fukuda, K., Nishi, Y., Usui, T., Mishima, H., Hirata, H., Baba, S., Choshi, K., Tanaka, Y., Akiya, S. <strong>Free amino acid concentrations in blood cells of two brothers with gyrate atrophy of the choroid and retina with hyperornithinaemia.</strong> J. Inherit. Metab. Dis. 6: 137-142, 1983.">Fukuda et al. (1983)</a>; <a href="#Kennaway1977" class="mim-tip-reference" title="Kennaway, N. G., Weleber, R. G., Buist, N. R. M. <strong>Gyrate atrophy of choroid and retina: deficient activity of ornithine ketoacid aminotransferase in cultured skin fibroblasts. (Letter)</strong> New Eng. J. Med. 297: 1180 only, 1977.">Kennaway et
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al. (1977)</a>; <a href="#Kennaway1980" class="mim-tip-reference" title="Kennaway, N. G., Weleber, R. G., Buist, N. R. M. <strong>Gyrate atrophy of the choroid and retina with hyperornithinemia: biochemical and histologic studies and response to vitamin B6.</strong> Am. J. Hum. Genet. 32: 529-541, 1980.">Kennaway et al. (1980)</a>; <a href="#McInnes1981" class="mim-tip-reference" title="McInnes, R. R., Arshinoff, S. A., Bell, L., Marliss, E. B., McCulloch, J. C. <strong>Hyperornithinaemia and gyrate atrophy of the retina: improvement of vision during treatment with a low-arginine diet.</strong> Lancet 317: 513-516, 1981. Note: Originally Volume I.">McInnes et al. (1981)</a>; <a href="#O'Donnell1978" class="mim-tip-reference" title="O'Donnell, J. J., Sandman, R. P., Martin, S. R. <strong>Gyrate atrophy of the retina: inborn error of L-ornithine: 2-oxoacid aminotransferase.</strong> Science 200: 200-201, 1978.">O'Donnell
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et al. (1978)</a>; <a href="#Shih1978" class="mim-tip-reference" title="Shih, V. E., Berson, E. L., Mandell, R., Schmidt, S. Y. <strong>Ornithine ketoacid transaminase deficiency in gyrate atrophy of the choroid and retina.</strong> Am. J. Hum. Genet. 30: 174-179, 1978.">Shih et al. (1978)</a>; <a href="#Sipila1981" class="mim-tip-reference" title="Sipila, I., Simell, O., O'Donnell, J. J. <strong>Gyrate atrophy of the choroid and retina with hyperornithinemia: characterization of mutant liver L-ornithine:2-oxoacid aminotransferase kinetics.</strong> J. Clin. Invest. 67: 1805-1807, 1981.">Sipila et al. (1981)</a>; <a href="#Sipila1980" class="mim-tip-reference" title="Sipila, I., Simell, O., Takki, K. <strong>Hyperornithinemia with gyrate atrophy of the choroid and retina (HOGA). In: Eriksson, A. W.; Forsius, H. R.; Nevanlinna, H. R.; Workman, P. L.; Norio, R. K. (eds.): Population Structure and Genetic Disorders.</strong> New York: Academic Press (pub.) 1980. Pp. 620-625.">Sipila et
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al. (1980)</a>; <a href="#Sipila1981" class="mim-tip-reference" title="Sipila, I., Simell, O., O'Donnell, J. J. <strong>Gyrate atrophy of the choroid and retina with hyperornithinemia: characterization of mutant liver L-ornithine:2-oxoacid aminotransferase kinetics.</strong> J. Clin. Invest. 67: 1805-1807, 1981.">Sipila et al. (1981)</a>; <a href="#Sipila1980" class="mim-tip-reference" title="Sipila, I., Simell, O., Takki, K. <strong>Hyperornithinemia with gyrate atrophy of the choroid and retina (HOGA). In: Eriksson, A. W.; Forsius, H. R.; Nevanlinna, H. R.; Workman, P. L.; Norio, R. K. (eds.): Population Structure and Genetic Disorders.</strong> New York: Academic Press (pub.) 1980. Pp. 620-625.">Sipila et al. (1980)</a>; <a href="#Takki1974" class="mim-tip-reference" title="Takki, K., Simell, O. <strong>Genetic aspects in gyrate atrophy of the choroid and retina with hyperornithinaemia.</strong> Brit. J. Ophthal. 58: 907-916, 1974.">Takki and
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Simell (1974)</a>
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<strong>A review of treatment modalities in gyrate atrophy of the choroid and retina (GACR).</strong>
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[<a href="https://doi.org/10.1016/j.ymgme.2021.07.010" target="_blank">Full Text</a>]
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Brody, L. C., Mitchell, G. A., Obie, C., Michaud, J., Steel, G., Fontaine, G., Robert, M.-F., Sipila, I., Kaiser-Kupfer, M., Valle, D.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11346393/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11346393</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11346393" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1001/archopht.119.5.667" target="_blank">Full Text</a>]
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Francois, J., Barbier, F., De Rouck, A.
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<strong>Les conducteurs du gene de l'atrophia gyrata chorioideae et retinae de fuchs (anomalie d'Alder).</strong>
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/13824432/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">13824432</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=13824432" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1017/s1120962300018448" target="_blank">Full Text</a>]
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Francois, J., Barbier, F., De Rouck, A.
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<strong>A propos des conducteurs du gene de l'atrophia gyrata chorioideae et retinae de fuchs.</strong>
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5930170/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5930170</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5930170" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1017/s1120962300013573" target="_blank">Full Text</a>]
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Francois, J.
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<strong>Heredity in Ophthalmology.</strong>
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St. Louis: C. V. Mosby (pub.) 1961.
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Francois, J.
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<strong>Progress in ophthalmic genetics. In: Steinberg, A. G.; Bearn, A. G. (eds.): Progress in Medical Genetics. Vol. II.</strong>
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Fukuda, K., Nishi, Y., Usui, T., Mishima, H., Hirata, H., Baba, S., Choshi, K., Tanaka, Y., Akiya, S.
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<strong>Free amino acid concentrations in blood cells of two brothers with gyrate atrophy of the choroid and retina with hyperornithinaemia.</strong>
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J. Inherit. Metab. Dis. 6: 137-142, 1983.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6422152/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6422152</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6422152" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1007/BF02310866" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1001/archopht.120.2.146" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1126/science.7444439" target="_blank">Full Text</a>]
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Kennaway, N. G., Stankova, L., Wirtz, M. K., Weleber, R. G.
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<strong>Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6.</strong>
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Kennaway, N. G., Weleber, R. G., Buist, N. R. M.
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<strong>Gyrate atrophy of choroid and retina: deficient activity of ornithine ketoacid aminotransferase in cultured skin fibroblasts. (Letter)</strong>
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/917049/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">917049</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=917049" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1056/nejm197711242972116" target="_blank">Full Text</a>]
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Kennaway, N. G., Weleber, R. G., Buist, N. R. M.
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[<a href="https://doi.org/10.1016/s0140-6736(81)92858-0" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1172/JCI113365" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1126/science.635581" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1212/wnl.59.5.735" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1016/s0140-6736(73)90667-3" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1056/NEJM198104093041503" target="_blank">Full Text</a>]
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<strong>Gyrate atrophy of the choroid and retina with hyperornithinemia: deficient formation of guanidinoacetic acid from arginine.</strong>
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[<a href="https://doi.org/10.1172/JCI109905" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1172/jci110222" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1212/wnl.29.7.996" target="_blank">Full Text</a>]
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[<a href="https://doi.org/10.1073/pnas.74.11.5159" target="_blank">Full Text</a>]
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<a id="Valtonen1996" class="mim-anchor"></a>
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Valtonen, M., Nanto-Salonen, K., Heinanen, K., Alanen, A., Kalimo, H., Simell, O.
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<strong>Skeletal muscle of patients with gyrate atrophy of the choroid and retina and hyperornithinaemia in ultralow-field magnetic resonance imaging and computed tomography.</strong>
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J. Inherit. Metab. Dis. 19: 729-734, 1996.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8982944/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8982944</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8982944" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1007/BF01799162" target="_blank">Full Text</a>]
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<a id="Valtonen1999" class="mim-anchor"></a>
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Valtonen, M., Nanto-Salonen, K., Jaaskelainen, S., Heinanen, K., Alanen, A., Heinonen, O. J., Lundbom, N., Erkintalo, M., Simell, O.
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<strong>Central nervous system involvement in gyrate atrophy of the choroid and retina with hyperornithinaemia.</strong>
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J. Inherit. Metab. Dis. 22: 855-866, 1999.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10604138/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10604138</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10604138" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1023/a:1005602405349" target="_blank">Full Text</a>]
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<a id="36" class="mim-anchor"></a>
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<a id="Wang1995" class="mim-anchor"></a>
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<div class="">
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Wang, T., Lawler, A. M., Steel, G., Sipila, I., Milam, A. H., Valle, D.
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<strong>Mice lacking ornithine-delta-amino-transferase have paradoxical neonatal hypoornithinaemia and retinal degeneration.</strong>
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Nature Genet. 11: 185-190, 1995.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7550347/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7550347</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7550347" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/ng1095-185" target="_blank">Full Text</a>]
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<a id="Wang2000" class="mim-anchor"></a>
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Wang, T., Steel, G., Milam, A. H., Valle, D.
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<strong>Correction of ornithine accumulation prevents retinal degeneration in a mouse model of gyrate atrophy of the choroid and retina.</strong>
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Proc. Nat. Acad. Sci. 97: 1224-1229, 2000.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10655512/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10655512</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=10655512[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10655512" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1073/pnas.97.3.1224" target="_blank">Full Text</a>]
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<a id="Wirtz1985" class="mim-anchor"></a>
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Wirtz, M. K., Kennaway, N. G., Weleber, R. G.
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<strong>Heterogeneity and complementation analysis of fibroblasts from vitamin B6 responsive and non-responsive patients with gyrate atrophy of the choroid and retina.</strong>
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J. Inherit. Metab. Dis. 8: 71-74, 1985.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3939534/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3939534</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3939534" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1007/BF01801668" target="_blank">Full Text</a>]
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<span class="mim-text-font">
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Hilary J. Vernon - updated : 06/23/2022
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Carol A. Bocchini - updated : 4/9/2010<br>Victor A. McKusick - updated : 3/8/2007<br>Jane Kelly - updated : 11/4/2002<br>Jane Kelly - updated : 7/6/2001<br>Victor A. McKusick - updated : 2/22/2000<br>Victor A. McKusick - updated : 12/21/1999<br>Victor A. McKusick - updated : 5/30/1997<br>Victor A. McKusick - updated : 4/1/1997<br>Victor A. McKusick - edited : 3/7/1997
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Creation Date:
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Victor A. McKusick : 6/4/1986
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carol : 06/23/2022
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carol : 09/09/2016<br>carol : 07/09/2016<br>terry : 9/9/2010<br>terry : 5/11/2010<br>terry : 5/11/2010<br>carol : 4/26/2010<br>carol : 4/9/2010<br>terry : 4/9/2010<br>carol : 4/8/2010<br>carol : 4/20/2009<br>terry : 3/13/2009<br>carol : 12/7/2007<br>carol : 12/5/2007<br>carol : 12/5/2007<br>carol : 10/23/2007<br>ckniffin : 10/22/2007<br>alopez : 3/8/2007<br>alopez : 3/17/2004<br>carol : 3/11/2003<br>cwells : 11/4/2002<br>carol : 7/11/2001<br>mcapotos : 7/6/2001<br>mcapotos : 3/13/2000<br>terry : 2/22/2000<br>carol : 1/3/2000<br>terry : 12/21/1999<br>carol : 9/22/1999<br>terry : 5/30/1997<br>jenny : 4/1/1997<br>alopez : 3/28/1997<br>terry : 3/21/1997<br>mark : 3/7/1997<br>joanna : 8/6/1996<br>mark : 10/24/1995<br>davew : 7/26/1994<br>terry : 7/15/1994<br>carol : 5/10/1994<br>warfield : 4/19/1994<br>mimadm : 3/11/1994
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<strong>#</strong> 258870
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GYRATE ATROPHY OF CHOROID AND RETINA; GACR
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<em>Alternative titles; symbols</em>
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HYPERORNITHINEMIA WITH GYRATE ATROPHY OF CHOROID AND RETINA; HOGA<br />
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GYRATE ATROPHY<br />
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ORNITHINE AMINOTRANSFERASE DEFICIENCY<br />
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OAT DEFICIENCY<br />
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ORNITHINE KETO ACID AMINOTRANSFERASE DEFICIENCY<br />
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OKT DEFICIENCY<br />
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ORNITHINE-DELTA-AMINOTRANSFERASE DEFICIENCY
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<strong>SNOMEDCT:</strong> 276426004, 314467007, 33985005;
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<strong>ORPHA:</strong> 414;
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<strong>DO:</strong> 1415;
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<strong>Phenotype-Gene Relationships</strong>
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<table class="table table-bordered table-condensed small mim-table-padding">
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Phenotype
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Inheritance
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Phenotype <br /> mapping key
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<span class="mim-font">
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10q26.13
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<span class="mim-font">
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Gyrate atrophy of choroid and retina with or without ornithinemia
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258870
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Autosomal recessive
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3
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OAT
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613349
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<strong>TEXT</strong>
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<p>A number sign (#) is used with this entry because gyrate atrophy of the choroid and retina (GACR) is caused by homozygous or compound heterozygous mutation in the OAT gene (613349) on chromosome 10q26.</p>
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<strong>Description</strong>
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<p>Gyrate atrophy of the choroid and retina (GACR) due to deficiency of ornithine aminotransferase is clinically characterized by a triad of progressive chorioretinal degeneration, early cataract formation, and type II muscle fiber atrophy. Characteristic chorioretinal atrophy with progressive constriction of the visual fields leads to blindness at the latest during the sixth decade of life. Patients generally have normal intelligence (summary by Peltola et al., 2002). </p><p>See 238970 for another hyperornithinemia syndrome.</p>
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<strong>Clinical Features</strong>
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<p>Hyperornithinemia presumably due to deficiency of ornithine ketoacid aminotransferase was found in 9 patients with gyrate atrophy of the choroid and retina (Simell and Takki, 1973). The clinical history of gyrate atrophy is usually night blindness that begins in late childhood, accompanied by sharply demarcated circular areas of chorioretinal atrophy. During the second and third decades the areas of atrophy enlarge. Ornithine levels were 10 to 20 times higher than normal in plasma, urine, spinal fluid, and aqueous humor. No consistent clinical abnormality other than the ocular one was found. Hyperammonemia was not found in the fasting state or after meals or stress testing. All the patients' parents were from the same geographic area of Finland. </p><p>Most patients with gyrate atrophy have posterior subcapsular cataracts by the end of the second decade (Kaiser-Kupfer et al., 1983). </p><p>Sipila et al. (1979) studied 21 patients with gyrate atrophy with hyperornithinemia and found that type II muscle fibers were almost universally atrophic and had tubular aggregates. Despite the changes in type II fibers, the patients usually had no muscle symptoms, although some showed impaired performance when speed or acute strength was required. The disease progresses to almost complete loss of type II fibers, but the progression of muscle changes is slower than that of ocular pathology. Valtonen et al. (1996) found type II muscle fiber atrophy in all 7 patients with gyrate atrophy studied by muscle biopsy and found tubular aggregates in 6 of the 7 patients. CT and MRI studies showed changes in the thigh muscles in all patients. </p><p>It has been suggested that changes in skeletal muscle, as well as the ocular changes, may be mediated by hyperornithinemia-induced deficiency of high-energy creatine phosphate. Abnormal brain MRI and EEG studies are found in another disorder of creatine metabolism, guanidinoacetate methyltransferase deficiency (612736); for this reason, Valtonen et al. (1999) investigated CNS involvement in gyrate atrophy, which seems to be associated with a milder degree of phosphocreatine deficiency. They compared 23 untreated gyrate atrophy patients with age-matched healthy controls, and with 9 patients who had received creatine or creatine precursor supplementation daily for several years. The MRI or EEG findings of the patients on creatine supplementation did not differ from those of the untreated group. Brain MRI revealed degenerative lesions in the white matter in 50% of the gyrate atrophy patients, and 70% of the patients had premature atrophic changes, with a striking increase in the number of Virchow spaces. Of the patients whose EEG was recorded, 58% had abnormal slow background activity, focal lesions, or high-amplitude beta rhythm. The EEG findings were not associated with the MRI changes or with the age or sex of the patients. Valtonen et al. (1999) concluded that early degenerative and atrophic brain changes and abnormal EEG are features of gyrate atrophy, in addition to the well-characterized eye and muscle manifestations. </p><p>Stoppoloni et al. (1978) reported a patient with gyrate atrophy at age 3 years and 9 months who also had mild mental retardation, delayed language development, and speech defects. </p><p>Valle et al. (1977) demonstrated deficiency of ornithine-delta-aminotransferase, a pyridoxal-dependent enzyme, in transformed lymphocytes. </p><p>Some cases of OAT deficiency are B6-responsive. Wirtz et al. (1985) found no complementation when fibroblasts from four B6-responsive and three B6-nonresponsive patients were fused. This suggests that the 2 forms are allelic. B6-responsive patients had higher activity of OAT in cell homogenates and greater incorporation of radioactivity from (14)C-ornithine into protein in cultured cells in situ than did B6-unresponsive patients. </p><p>Shih et al. (1988) studied fibroblasts from heterozygotes for the pyridoxine-responsive variant and from heterozygotes for the pyridoxine-nonresponsive variant. Both contain intermediate levels of OAT activity. The 2 variants could be distinguished, however, by the in vitro responsiveness of OAT activity to pyridoxal phosphate (PLP) stimulation. The ratios of OAT with no PLP added were lowest for controls, intermediate for pyridoxine-nonresponsive heterozygotes, and highest for pyridoxine-responsive heterozygotes. Kennaway et al. (1989) studied the mutant enzyme in 9 patients with gyrate atrophy of the choroid and retina by use of a radiochemical assay to measure the Km for PLP in fibroblast mitochondria and the heat stability of OAT at 45 degrees in the presence and absence of PLP. The apparent Km for PLP was lower in nonresponsive patients than in patients responsive to pyridoxine. In 7 patients studied, the apparent Km for ornithine was normal. The patient with the mildest clinical disease, responsive to pyridoxine, had the most stable enzyme, but also the highest Km for PLP. OAT protein was clearly detectable by Western blot analysis of mitochondrial proteins in the pyridoxine-responsive patients and in 2 of 5 nonresponders, but was low or undetectable in the 3 other patients. </p>
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</span>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Inheritance</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Barrett et al. (1987) reviewed 80 reported cases of gyrate atrophy and concluded that the pattern of inheritance was always consistent with the autosomal recessive hypothesis. Forty-four, or 55%, were female. No significant quantitative differences in OAT deficiency had been found in cultured fibroblasts and lymphocytes from male and female patients. </p>
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</span>
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<div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Clinical Management</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>The main source of ornithine is arginine in dietary protein, and restriction of arginine in the diet appears to have therapeutic value (Kaiser-Kupfer et al., 1980; Valle et al., 1980). </p><p>Kaiser-Kupfer et al. (2002) reported the results of 16 to 17 years of arginine-restricted diet on 2 sib pairs. In both families, the younger sib in each pair, who was prescribed the diet at an earlier age, demonstrated a slower progression of lesions compared with the older sib. They concluded that, if started at an early age, long-term substantial reduction of plasma ornithine levels might appreciably slow the progression of the chorioretinal lesions and, to a lesser extent, the progressive loss of retinal function in patients with gyrate atrophy. </p><p>Balfoort et al. (2021) performed a literature review to assess treatment modalities in gyrate atrophy and found that a protein-restricted diet, pyridoxine supplementation, and/or lysine supplementation were effective in lowering plasma ornithine levels. Responsiveness to pyridoxine was associated with specific mutations in the OAT gene. However, Balfoort et al. (2021) concluded that a lack of uniform clinical outcome measures made it difficult to determine clinical effectiveness of these ornithine-lowering interventions. </p><p><strong><em>Gene Therapy</em></strong></p><p>
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Caruso et al. (2001) examined the course of change in visual function outcome variables in 5 patients with gyrate atrophy in anticipation of a gene replacement therapy clinical trial. In the 4 to 6 years during which each patient was followed, median visual field half-lives were 17.0 years (static perimetry) and 11.4 years (kinetic perimetry). Median electroretinogram half-lives were 16.0 years (maximal response) and 10.7 years (flicker response). The authors concluded that the decline in visual function outcome variables was frequently slow. Thus, a long-term clinical trial would be required to assess the efficacy of the intervention in the preservation of visual function in gyrate atrophy patients. </p>
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</span>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Population Genetics</strong>
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</span>
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</h4>
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<span class="mim-text-font">
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<p>Valle and Simell (2001) stated that approximately 200 biochemically confirmed cases of GACR are known. The incidence is highest in Finland, with an estimated frequency of about 1 in 50,000 individuals and an estimated frequency for heterozygotes of 1 in 110 individuals.</p>
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</span>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Mapping</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Ramesh et al. (1988) demonstrated that the OAT locus segregated concordantly with gyrate atrophy in 1 pedigree and showed significant disequilibrium with gyrate atrophy, thus providing genetic evidence that a defect in the OAT structural gene on chromosome 10 is the cause of the disorder. </p>
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</span>
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<div>
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<br />
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<div>
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<h4>
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<span class="mim-font">
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<strong>Molecular Genetics</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>In patients with gyrate atrophy of the choroid and retina, Mitchell et al. (1988) identified a mutation in the OAT gene (613349.0001). </p><p>Brody et al. (1992) discovered and characterized the molecular defect in 21 newly recognized OAT alleles. They determined the consequences of these and 3 previously described mutations on OAT mRNA, antigen, and enzyme activity in cultured fibroblasts. In 20 of the 24 alleles, normal amounts of normal-sized OAT mRNA were produced. By contrast, only 2 of the 24 had normal amounts of OAT antigen. </p>
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</span>
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<div>
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<br />
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Animal Model</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Wang et al. (1995) found that Oat-deficient mice produced by gene targeting exhibit neonatal hypoornithinemia and lethality, rescuable by short-term arginine supplementation. Postweaning, these mice developed hyperornithinemia similar to human gyrate atrophy patients. Studies in 1 human gyrate atrophy infant also showed transient hypoornithinemia. Thus, the authors concluded that the OAT reaction plays opposite roles in neonatal and adult mammals. Over several months, Oat-deficient mice develop a retinal degeneration with involvement of photoreceptors and pigment epithelium. Oat-deficient mice appear to be an authentic model of human gyrate atrophy. </p><p>To determine whether chronic, systemic reduction of ornithine can prevent gyrate atrophy, Wang et al. (2000) used an arginine-restricted diet to maintain long-term reduction of ornithine in the mouse model of Oat deficiency produced by gene targeting. They evaluated the mice over a 12-month period by measurement of plasma amino acids, electroretinograms, and retinal histology and ultrastructural studies. They found that an arginine-restricted diet substantially reduced plasma ornithine levels and completely prevented retinal degeneration in Oat -/- mice. This result indicated that ornithine accumulation is a necessary factor in the pathophysiology of the retinal degeneration in gyrate atrophy and that restoration of OAT activity in retina is not required for effective treatment of gyrate atrophy. </p>
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</span>
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<div>
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<br />
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>History</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Fuchs atrophia gyrata chorioideae et retinae is a rare disorder characterized by slowly progressive atrophy of the choroid, pigment epithelium, and retina. Francois et al. (1960) described a patient in which leukocyte inclusions were present not only in the patient but also in both parents, who were consanguineous, and in other members of the family through 4 generations. The authors originally suggested that the leukocyte anomaly was a heterozygous expression of the gene which in the homozygous state produces Fuchs atrophy. In a later publication, however, Francois et al. (1966) reported failure to find the Alder anomaly in 9 patients with the eye anomaly. The authors concluded that there is no true gyrate atrophy independent of ornithinemia. Presumed cases may represent simulating conditions. </p>
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</span>
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<div>
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<br />
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</div>
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>See Also:</strong>
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</span>
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</h4>
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<span class="mim-text-font">
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Francois (1961); Francois (1962); Fukuda et al. (1983); Kennaway et
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al. (1977); Kennaway et al. (1980); McInnes et al. (1981); O'Donnell
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|
et al. (1978); Shih et al. (1978); Sipila et al. (1981); Sipila et
|
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al. (1980); Sipila et al. (1981); Sipila et al. (1980); Takki and
|
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Simell (1974)
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</span>
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<div>
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<br />
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</div>
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>REFERENCES</strong>
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</span>
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</h4>
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<div>
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<p />
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</div>
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<div>
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<ol>
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<li>
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<p class="mim-text-font">
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Balfoort, B. M., Buijs, M. J. N., ten Asbroek, A. L. M. A., Bergen, A. A. B., Boon, C. J. F., Ferreira, E. A., Houtkooper, R. H., Wagenmakers, M. A. E. M., Wanders, R. J.A., Waterham, H. R., Timmer, C., van Karnebeek, C. D., Brands, M. M.
|
|
<strong>A review of treatment modalities in gyrate atrophy of the choroid and retina (GACR).</strong>
|
|
Molec. Genet. Metab. 134: 96-116, 2021.
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[PubMed: 34340878]
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[Full Text: https://doi.org/10.1016/j.ymgme.2021.07.010]
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</p>
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<p class="mim-text-font">
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Barrett, D. J., Bateman, J. B., Sparkes, R. S., Mohandas, T., Klisak, I., Inana, G.
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<strong>Chromosomal localization of human ornithine aminotransferase gene sequences to 10q26 and Xp11.2.</strong>
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Invest. Ophthal. Vis. Sci. 28: 1037-1042, 1987.
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<li>
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<p class="mim-text-font">
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Brody, L. C., Mitchell, G. A., Obie, C., Michaud, J., Steel, G., Fontaine, G., Robert, M.-F., Sipila, I., Kaiser-Kupfer, M., Valle, D.
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<strong>Ornithine delta-aminotransferase mutations in gyrate atrophy: allelic heterogeneity and functional consequences.</strong>
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J. Biol. Chem. 267: 3302-3307, 1992.
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<p class="mim-text-font">
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Caruso, R. C., Nussenblatt, R. B., Csaky, K. G., Valle, D., Kaiser-Kupfer, M. I.
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<strong>Assessment of visual function in patients with gyrate atrophy who are considered candidates for gene replacement.</strong>
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Arch. Ophthal. 119: 667-669, 2001.
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[PubMed: 11346393]
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[Full Text: https://doi.org/10.1001/archopht.119.5.667]
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<p class="mim-text-font">
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Francois, J., Barbier, F., De Rouck, A.
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<strong>Les conducteurs du gene de l'atrophia gyrata chorioideae et retinae de fuchs (anomalie d'Alder).</strong>
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Acta Genet. Med. Gemellol. 9: 74-91, 1960.
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[PubMed: 13824432]
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[Full Text: https://doi.org/10.1017/s1120962300018448]
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<li>
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<p class="mim-text-font">
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Francois, J., Barbier, F., De Rouck, A.
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<strong>A propos des conducteurs du gene de l'atrophia gyrata chorioideae et retinae de fuchs.</strong>
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Acta Genet. Med. Gemellol. 15: 34-35, 1966.
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[PubMed: 5930170]
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[Full Text: https://doi.org/10.1017/s1120962300013573]
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</p>
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<li>
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<p class="mim-text-font">
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Francois, J.
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<strong>Heredity in Ophthalmology.</strong>
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St. Louis: C. V. Mosby (pub.) 1961.
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<p class="mim-text-font">
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Francois, J.
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<strong>Progress in ophthalmic genetics. In: Steinberg, A. G.; Bearn, A. G. (eds.): Progress in Medical Genetics. Vol. II.</strong>
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New York: Grune and Stratton 1962. Pp. 331-365.
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</p>
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<li>
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Fukuda, K., Nishi, Y., Usui, T., Mishima, H., Hirata, H., Baba, S., Choshi, K., Tanaka, Y., Akiya, S.
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<strong>Free amino acid concentrations in blood cells of two brothers with gyrate atrophy of the choroid and retina with hyperornithinaemia.</strong>
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J. Inherit. Metab. Dis. 6: 137-142, 1983.
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[PubMed: 6422152]
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[Full Text: https://doi.org/10.1007/BF02310866]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Kaiser-Kupfer, M. I., Caruso, R. C., Valle, D.
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<strong>Gyrate atrophy of the choroid and retina: further experience with long-term reduction of ornithine levels in children.</strong>
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Arch. Ophthal. 120: 146-153, 2002.
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[PubMed: 11831916]
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[Full Text: https://doi.org/10.1001/archopht.120.2.146]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Kaiser-Kupfer, M. I., de Monasterio, F. M., Valle, D., Walser, M., Brusilow, S.
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<strong>Gyrate atrophy of the choroid and retina: improved visual function following reduction of plasma ornithine by diet.</strong>
|
|
Science 210: 1128-1131, 1980.
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[PubMed: 7444439]
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[Full Text: https://doi.org/10.1126/science.7444439]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
|
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Kaiser-Kupfer, M., Kuwabara, T., Uga, S., Takki, K., Valle, D.
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<strong>Cataracts in gyrate atrophy: clinical and morphologic studies.</strong>
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Invest. Ophthal. Vis. Sci. 24: 432-436, 1983.
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[PubMed: 6832916]
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<li>
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<p class="mim-text-font">
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Kennaway, N. G., Stankova, L., Wirtz, M. K., Weleber, R. G.
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<strong>Gyrate atrophy of the choroid and retina: characterization of mutant ornithine aminotransferase and mechanism of response to vitamin B6.</strong>
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Am. J. Hum. Genet. 44: 344-352, 1989.
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[PubMed: 2916580]
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<li>
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<p class="mim-text-font">
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Kennaway, N. G., Weleber, R. G., Buist, N. R. M.
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<strong>Gyrate atrophy of choroid and retina: deficient activity of ornithine ketoacid aminotransferase in cultured skin fibroblasts. (Letter)</strong>
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New Eng. J. Med. 297: 1180 only, 1977.
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[PubMed: 917049]
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[Full Text: https://doi.org/10.1056/nejm197711242972116]
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</p>
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<li>
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<p class="mim-text-font">
|
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Kennaway, N. G., Weleber, R. G., Buist, N. R. M.
|
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<strong>Gyrate atrophy of the choroid and retina with hyperornithinemia: biochemical and histologic studies and response to vitamin B6.</strong>
|
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Am. J. Hum. Genet. 32: 529-541, 1980.
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[PubMed: 7395865]
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</p>
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<li>
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<p class="mim-text-font">
|
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McInnes, R. R., Arshinoff, S. A., Bell, L., Marliss, E. B., McCulloch, J. C.
|
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<strong>Hyperornithinaemia and gyrate atrophy of the retina: improvement of vision during treatment with a low-arginine diet.</strong>
|
|
Lancet 317: 513-516, 1981. Note: Originally Volume I.
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[PubMed: 6111630]
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[Full Text: https://doi.org/10.1016/s0140-6736(81)92858-0]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
|
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Mitchell, G. A., Brody, L. C., Looney, J., Steel, G., Suchanek, M., Dowling, C., Der Kaloustian, V., Kaiser-Kupfer, M., Valle, D.
|
|
<strong>An initiator codon mutation in ornithine-delta-aminotransferase causing gyrate atrophy of the choroid and retina.</strong>
|
|
J. Clin. Invest. 81: 630-633, 1988.
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[PubMed: 3339136]
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[Full Text: https://doi.org/10.1172/JCI113365]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
|
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O'Donnell, J. J., Sandman, R. P., Martin, S. R.
|
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<strong>Gyrate atrophy of the retina: inborn error of L-ornithine: 2-oxoacid aminotransferase.</strong>
|
|
Science 200: 200-201, 1978.
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[PubMed: 635581]
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[Full Text: https://doi.org/10.1126/science.635581]
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Peltola, K. E., Jaaskelainen, S., Heinonen, O. J., Falck, B., Nanto-Salonen, K., Heinanen, K., Simell, O.
|
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<strong>Peripheral nervous system in gyrate atrophy of the choroid and retina with hyperornithinemia.</strong>
|
|
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