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Entry
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- *142800 - MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A
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- OMIM
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<div id="mimAlertBanner">
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<div id="mimFloatingTocMenu" class="small" role="navigation">
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<p>
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<span class="h4">*142800</span>
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<br />
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<strong>Table of Contents</strong>
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</p>
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<nav>
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<ul id="mimFloatingTocMenuItems" class="nav nav-pills nav-stacked mim-floating-toc-padding">
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<li role="presentation">
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<a href="#title"><strong>Title</strong></a>
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</li>
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<li role="presentation">
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<a href="#geneMap"><strong>Gene-Phenotype Relationships</strong></a>
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</li>
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<li role="presentation">
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<a href="#text"><strong>Text</strong></a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#description">Description</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#geneStructure">Gene Structure</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#mapping">Mapping</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#evolution">Evolution</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#geneFunction">Gene Function</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#molecularGenetics">Molecular Genetics</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#animalModel">Animal Model</a>
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</li>
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<li role="presentation" style="margin-left: 1em">
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<a href="#history">History</a>
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</li>
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<li role="presentation">
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<a href="#allelicVariants"><strong>Allelic Variants</strong></a>
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</li>
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<li role="presentation" style="margin-left: 1em">
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<a href="/allelicVariants/142800">Table View</a>
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</li>
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<li role="presentation">
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<a href="#seeAlso"><strong>See Also</strong></a>
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</li>
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<li role="presentation">
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<a href="#references"><strong>References</strong></a>
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</li>
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<li role="presentation">
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<a href="#contributors"><strong>Contributors</strong></a>
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</li>
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<li role="presentation">
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<a href="#creationDate"><strong>Creation Date</strong></a>
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</li>
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<li role="presentation">
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<a href="#editHistory"><strong>Edit History</strong></a>
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</li>
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</ul>
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</nav>
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</div>
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</div>
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<div class="col-lg-2 col-lg-push-8 col-md-2 col-md-push-8 col-sm-2 col-sm-push-8 col-xs-12">
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<div id="mimFloatingLinksMenu">
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<div class="panel panel-primary" style="margin-bottom: 0px; border-radius: 4px 4px 0px 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimExternalLinks">
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<h4 class="panel-title">
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<a href="#mimExternalLinksFold" id="mimExternalLinksToggle" class="mimTriangleToggle" role="button" data-toggle="collapse">
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<div style="display: table-row">
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<div id="mimExternalLinksToggleTriangle" class="small" style="color: white; display: table-cell;">▼</div>
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<div style="display: table-cell;">External Links</div>
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</div>
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</a>
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</h4>
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</div>
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</div>
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<div id="mimExternalLinksFold" class="collapse in">
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<div class="panel-group" id="mimExternalLinksAccordion" role="tablist" aria-multiselectable="true">
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimGenome">
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<span class="panel-title">
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<span class="small">
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<a href="#mimGenomeLinksFold" id="mimGenomeLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimGenomeLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Genome
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</a>
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</span>
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</span>
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</div>
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<div id="mimGenomeLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="genome">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000206503;t=ENST00000376809" class="mim-tip-hint" title="Genome databases for vertebrates and other eukaryotic species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/genome/gdv/browser/gene/?id=3105" class="mim-tip-hint" title="Detailed views of the complete genomes of selected organisms from vertebrates to protozoa." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Genome Viewer', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Genome Viewer</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=142800" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimDna">
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<span class="panel-title">
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<span class="small">
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<a href="#mimDnaLinksFold" id="mimDnaLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimDnaLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> DNA
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</a>
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</span>
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</span>
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</div>
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<div id="mimDnaLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Transcript/Sequence_cDNA?db=core;g=ENSG00000206503;t=ENST00000376809" class="mim-tip-hint" title="Transcript-based views for coding and noncoding DNA." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl (MANE Select)</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_002116" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_002116" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq (MANE)', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq (MANE Select)</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=142800" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimProtein">
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<span class="panel-title">
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<span class="small">
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<a href="#mimProteinLinksFold" id="mimProteinLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimProteinLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Protein
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</a>
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</span>
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</span>
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</div>
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<div id="mimProteinLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://hprd.org/summary?hprd_id=00826&isoform_id=00826_1&isoform_name=Isoform_1" class="mim-tip-hint" title="The Human Protein Reference Database; manually extracted and visually depicted information on human proteins." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HPRD', 'domain': 'hprd.org'})">HPRD</a></div>
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<div><a href="https://www.proteinatlas.org/search/HLA-A" class="mim-tip-hint" title="The Human Protein Atlas contains information for a large majority of all human protein-coding genes regarding the expression and localization of the corresponding proteins based on both RNA and protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HumanProteinAtlas', 'domain': 'proteinatlas.org'})">Human Protein Atlas</a></div>
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<div><a 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910735813,913375170,914407734,918465196,918776517,922664507,922664509,922664511,926438186,927144618,927144623,927144654,927927653,927927655,930056345,930626334,930715702,930715707,930841419,933617598,933617713,933617800,933617849,933617985,936370376,936370382,936370389,936370398,936370420,936370442,936910406,936910408,939107430,939460787,949377489,949377491,950648513,950648515,952979009,952979015,952979017,952987933,952987937,954330850,954330857,954330866,954330871,954330878,954330883,954330887,955665040,955665042,958108979,958108983,958109181,960515881,960515883,960515885,961349200,961349202,961349204,961349206,961349210,961349212,961349214,961349216,961349218,961349220,961349222,961349226,961349228,961349230,961349232,961349234,961349236,961349238,961349240,961349242,961349244,961349246,961349248,961349250,961349252,961349254,961349256,961349258,961349260,961349262,961349264,961349266,961349268,961349270,961349273,961349275,961349277,961349279,961349281,961349283,961349285,961349287,961349289,961349291,961349293,961349295,961349297,961349300,961349303,961349305,961349307,961349309,961349311,961349317,961349320,961349322,961349324,961349326,961349329,961349331,961349333,961349335,961349337,961349339,961349341,961349343,961349345,961349348,961349350,961349352,961349354,961349356,961349358,961349360,961349362,961349364,961349367,961349369,961349371,961349374,961349376,961349378,961349380,961349382,961349384,961349386,961349389,961349391,961349393,961349395,961349397,961349399,961349401,961349403,961349405,961349407,961349411,961349413,961349415,961349417,961349419,961349421,961349423,961349425,961349427,961349429,961349431,961349433,961349435,961349437,961349439,961349441,961349443,961349445,961349447,961349449,961349451,961349453,961349455,961349457,961349459,961349461,961349463,961349465,961349467,961349469,961349472,961349474,961349476,961349478,961349480,961349482,961349484,961349486,961349488,961527798,961527802,961556245,961556247,961556249,963528060,963528072,966798169,971459887,974048861,974397855,974397858,974397861,974397871,974397945,974569604,974569606,974569608,974569610,974569612,974569614,974569616,974569618,974569620,974569622,974569624,974569626,974569628,974569630,974569632,974569634,974569636,974569638,974569641,974569643,974569645,974569647,974569649,974569651,974569653,974569655,974569657,974569659,974569661,974569663,974569665,974569667,974569669,974569671,974569673,974569676,974569679,974569681,974569684,974569686,974569688,974569690,974569692,974569694,974569696,974569698,974569700,974569702,974569704,974569707,974569709,974569711,974569713,974569715,974569717,974569719,974569721,974569723,974569725,974569727,974569729,974569731,974569733,974569735,974569737,974569739,974569741,974569743,974569745,974569747,974569749,974569751,974569753,974707004,974707006,975825300,975825306,982326904,983174661,983174663,983174665,983656515,985477903,985477905,985477907,985560725,985700642,985742537,985742539,987919145,991461194,992391275,998453999,998615893,1001184033,1001229351,1002340238,1003310501,1003310506,1003310514,1003310516,1005139288,1005139290,1007870868,1007870931,1008904281,1009335660,1009427513,1009427515,1009427521,1009427523,1009427525,1009427527,1009427529,1009427531,1009427533,1009427535,1009427537,1009427539,1009427541,1009427657,1009427662,1009427664,1009427666,1009427668,1009427952,1009427954,1009427956,1009427965,1009427967,1011326606,1016149551,1022611504,1024212634,1024212646,1024212648,1024212650,1025608502,1025608504,1025608509,1025608517,1028614937,1031607309,1031607311,1031607313,1031607320,1031607330,1031978512,1032797888,1032797890,1032797892,1032797896,1032797898,1032797900,1032797902,1032797904,1032797906,1113818657,1167503232,1167503234,1167503236,2040144469,2040144471,2912143544" class="mim-tip-hint" title="NCBI protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Protein', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Protein</a></div>
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<div><a href="https://www.uniprot.org/uniprotkb/?query=P01893 OR P04439" class="mim-tip-hint" title="Comprehensive protein sequence and functional information, including supporting data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UniProt', 'domain': 'uniprot.org'})">UniProt</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimGeneInfo">
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<span class="panel-title">
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<span class="small">
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<a href="#mimGeneInfoLinksFold" id="mimGeneInfoLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimGeneInfoLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Gene Info</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimGeneInfoLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="http://biogps.org/#goto=genereport&id=3105" class="mim-tip-hint" title="The Gene Portal Hub; customizable portal of gene and protein function information." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'BioGPS', 'domain': 'biogps.org'})">BioGPS</a></div>
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<div><a href="https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000206503;t=ENST00000376809" class="mim-tip-hint" title="Orthologs, paralogs, regulatory regions, and splice variants." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=HLA-A" class="mim-tip-hint" title="The Human Genome Compendium; web-based cards integrating automatically mined information on human genes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneCards', 'domain': 'genecards.org'})">GeneCards</a></div>
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<div><a href="http://amigo.geneontology.org/amigo/search/annotation?q=HLA-A" class="mim-tip-hint" title="Terms, defined using controlled vocabulary, representing gene product properties (biologic process, cellular component, molecular function) across species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneOntology', 'domain': 'amigo.geneontology.org'})">Gene Ontology</a></div>
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<div><a href="https://www.genome.jp/dbget-bin/www_bget?hsa+3105" class="mim-tip-hint" title="Kyoto Encyclopedia of Genes and Genomes; diagrams of signaling pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'KEGG', 'domain': 'genome.jp'})">KEGG</a></div>
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<dd><a href="http://v1.marrvel.org/search/gene/HLA-A" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></dd>
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<dd><a href="https://monarchinitiative.org/NCBIGene:3105" class="mim-tip-hint" title="Monarch Initiative." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Monarch', 'domain': 'monarchinitiative.org'})">Monarch</a></dd>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/3105" class="mim-tip-hint" title="Gene-specific map, sequence, expression, structure, function, citation, and homology data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Gene', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Gene</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_chrom=chr6&hgg_gene=ENST00000376809.10&hgg_start=29942532&hgg_end=29945870&hgg_type=knownGene" class="mim-tip-hint" title="UCSC Genome Bioinformatics; gene-specific structure and function information with links to other databases." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC', 'domain': 'genome.ucsc.edu'})">UCSC</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
|
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<div class="panel-heading mim-panel-heading" role="tab" id="mimClinicalResources">
|
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<span class="panel-title">
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<span class="small">
|
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<a href="#mimClinicalResourcesLinksFold" id="mimClinicalResourcesLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
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<div style="display: table-row">
|
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<div id="mimClinicalResourcesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Clinical Resources</div>
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</div>
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</a>
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</span>
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</span>
|
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</div>
|
|
<div id="mimClinicalResourcesLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="clinicalResources">
|
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=142800[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
|
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<div class="panel-heading mim-panel-heading" role="tab" id="mimVariation">
|
|
<span class="panel-title">
|
|
<span class="small">
|
|
<a href="#mimVariationLinksFold" id="mimVariationLinksToggle" class=" mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
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<span id="mimVariationLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">▼</span> Variation
|
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</a>
|
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</span>
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</span>
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</div>
|
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<div id="mimVariationLinksFold" class="panel-collapse collapse in mimLinksFold" role="tabpanel">
|
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ncbi.nlm.nih.gov/clinvar?term=142800[MIM]" class="mim-tip-hint" title="ClinVar aggregates information about sequence variation and its relationship to human health." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ClinVar', 'domain': 'ncbi.nlm.nih.gov'})">ClinVar</a></div>
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<div><a href="https://gnomad.broadinstitute.org/gene/ENSG00000206503" class="mim-tip-hint" title="The Genome Aggregation Database (gnomAD), Broad Institute." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'gnomAD', 'domain': 'gnomad.broadinstitute.org'})">gnomAD</a></div>
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<div><a href="https://www.ebi.ac.uk/gwas/search?query=HLA-A" class="mim-tip-hint" title="GWAS Catalog; NHGRI-EBI Catalog of published genome-wide association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Catalog', 'domain': 'gwascatalog.org'})">GWAS Catalog </a></div>
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<div><a href="https://www.gwascentral.org/search?q=HLA-A" class="mim-tip-hint" title="GWAS Central; summary level genotype-to-phenotype information from genetic association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Central', 'domain': 'gwascentral.org'})">GWAS Central </a></div>
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<div><a href="http://www.hgmd.cf.ac.uk/ac/gene.php?gene=HLA-A" class="mim-tip-hint" title="Human Gene Mutation Database; published mutations causing or associated with human inherited disease; disease-associated/functional polymorphisms." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HGMD', 'domain': 'hgmd.cf.ac.uk'})">HGMD</a></div>
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<div><a href="http://www.ebi.ac.uk/imgt/hla/" class="mim-tip-hint" title="A gene-specific database of variation." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Locus Specific DB', 'domain': 'locus-specific-db.org'})">Locus Specific DBs</a></div>
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<div><a href="https://evs.gs.washington.edu/EVS/PopStatsServlet?searchBy=Gene+Hugo&target=HLA-A&upstreamSize=0&downstreamSize=0&x=0&y=0" class="mim-tip-hint" title="National Heart, Lung, and Blood Institute Exome Variant Server." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NHLBI EVS', 'domain': 'evs.gs.washington.edu'})">NHLBI EVS</a></div>
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<div><a href="https://www.pharmgkb.org/gene/PA35055" class="mim-tip-hint" title="Pharmacogenomics Knowledge Base; curated and annotated information regarding the effects of human genetic variations on drug response." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PharmGKB', 'domain': 'pharmgkb.org'})">PharmGKB</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
|
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<div class="panel-heading mim-panel-heading" role="tab" id="mimAnimalModels">
|
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<span class="panel-title">
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<span class="small">
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<a href="#mimAnimalModelsLinksFold" id="mimAnimalModelsLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
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<div style="display: table-row">
|
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<div id="mimAnimalModelsLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
|
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<div style="display: table-cell;">Animal Models</div>
|
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</div>
|
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</a>
|
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</span>
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</span>
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</div>
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<div id="mimAnimalModelsLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
|
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.alliancegenome.org/gene/HGNC:4931" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
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<div><a href="https://www.mousephenotype.org/data/search?q=MGI:95896 MGI:95904 MGI:95928 MGI:95929 MGI:95931 MGI:95933 MGI:95935 MGI:95936" class="mim-tip-hint" title="International Mouse Phenotyping Consortium." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'IMPC', 'domain': 'knockoutmouse.org'})">IMPC</a></div>
|
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<div><a href="http://v1.marrvel.org/search/gene/HLA-A#HomologGenesPanel" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></div>
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<div><a href="http://www.informatics.jax.org/batch/summary?idType=MGI&ids=MGI:95896 MGI:95904 MGI:95928 MGI:95929 MGI:95931 MGI:95933 MGI:95935 MGI:95936" class="mim-tip-hint" title="Mouse Genome Informatics; international database resource for the laboratory mouse, including integrated genetic, genomic, and biological data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Gene', 'domain': 'informatics.jax.org'})">MGI Mouse Gene</a></div>
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<div><a href="https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=" class="mim-tip-hint" title="Mutant Mouse Resource & Research Centers." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MMRRC', 'domain': 'mmrrc.org'})">MMRRC</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/3105/ortholog/" class="mim-tip-hint" title="Orthologous genes at NCBI." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Orthologs', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Orthologs</a></div>
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<div><a href="https://www.orthodb.org/?ncbi=3105" class="mim-tip-hint" title="Hierarchical catalogue of orthologs." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'OrthoDB', 'domain': 'orthodb.org'})">OrthoDB</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
|
|
<div class="panel-heading mim-panel-heading" role="tab" id="mimCellLines">
|
|
<span class="panel-title">
|
|
<span class="small">
|
|
<a href="#mimCellLinesLinksFold" id="mimCellLinesLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
|
<div style="display: table-row">
|
|
<div id="mimCellLinesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
|
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|
|
<div style="display: table-cell;">Cell Lines</div>
|
|
</div>
|
|
</a>
|
|
</span>
|
|
</span>
|
|
</div>
|
|
<div id="mimCellLinesLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
|
|
<div class="panel-body small mim-panel-body">
|
|
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<div><a href="https://catalog.coriell.org/Search?q=OmimNum:142800" class="definition" title="Coriell Cell Repositories; cell cultures and DNA derived from cell cultures." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'CCR', 'domain': 'ccr.coriell.org'})">Coriell</a></div>
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|
</div>
|
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</div>
|
|
</div>
|
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|
|
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|
|
<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
|
|
<div class="panel-heading mim-panel-heading" role="tab" id="mimCellularPathways">
|
|
<span class="panel-title">
|
|
<span class="small">
|
|
<a href="#mimCellularPathwaysLinksFold" id="mimCellularPathwaysLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
|
<div style="display: table-row">
|
|
<div id="mimCellularPathwaysLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
|
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|
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<div style="display: table-cell;">Cellular Pathways</div>
|
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</div>
|
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</a>
|
|
</span>
|
|
</span>
|
|
</div>
|
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<div id="mimCellularPathwaysLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
|
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3105" class="mim-tip-hint" title="Kyoto Encyclopedia of Genes and Genomes; diagrams of signaling pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'KEGG', 'domain': 'genome.jp'})">KEGG</a></div>
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<div><a href="https://reactome.org/content/query?q=HLA-A&species=Homo+sapiens&types=Reaction&types=Pathway&cluster=true" class="definition" title="Protein-specific information in the context of relevant cellular pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {{'name': 'Reactome', 'domain': 'reactome.org'}})">Reactome</a></div>
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</div>
|
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</div>
|
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</div>
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</div>
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</div>
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</div>
|
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<span>
|
|
<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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</span>
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</span>
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</div>
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<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
|
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|
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<div>
|
|
|
|
<a id="title" class="mim-anchor"></a>
|
|
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<div>
|
|
<a id="number" class="mim-anchor"></a>
|
|
<div class="text-right">
|
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|
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</div>
|
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<div>
|
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<span class="h3">
|
|
<span class="mim-font mim-tip-hint" title="Gene description">
|
|
<span class="text-danger"><strong>*</strong></span>
|
|
142800
|
|
</span>
|
|
</span>
|
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</div>
|
|
</div>
|
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<div>
|
|
<a id="preferredTitle" class="mim-anchor"></a>
|
|
<h3>
|
|
<span class="mim-font">
|
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|
|
MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A
|
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|
|
</span>
|
|
</h3>
|
|
</div>
|
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<div>
|
|
<br />
|
|
</div>
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|
|
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<div>
|
|
<a id="alternativeTitles" class="mim-anchor"></a>
|
|
<div>
|
|
<p>
|
|
<span class="mim-font">
|
|
<em>Alternative titles; symbols</em>
|
|
</span>
|
|
</p>
|
|
</div>
|
|
<div>
|
|
<h4>
|
|
<span class="mim-font">
|
|
HLA-A HISTOCOMPATIBILITY TYPE
|
|
</span>
|
|
</h4>
|
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</div>
|
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</div>
|
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<div>
|
|
<br />
|
|
</div>
|
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<div>
|
|
<a id="includedTitles" class="mim-anchor"></a>
|
|
<div>
|
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<p>
|
|
<span class="mim-font">
|
|
Other entities represented in this entry:
|
|
</span>
|
|
</p>
|
|
</div>
|
|
<div>
|
|
<span class="h3 mim-font">
|
|
MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, H PSEUDOGENE, INCLUDED; HLA-H, INCLUDED
|
|
</span>
|
|
</div>
|
|
|
|
<div>
|
|
<span class="h4 mim-font">
|
|
|
|
MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, J PSEUDOGENE, INCLUDED; HLA-J, INCLUDED
|
|
</span>
|
|
</div>
|
|
|
|
</div>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
|
|
</div>
|
|
|
|
|
|
|
|
<div>
|
|
<a id="approvedGeneSymbols" class="mim-anchor"></a>
|
|
<p>
|
|
<span class="mim-text-font">
|
|
<strong><em>HGNC Approved Gene Symbol: <a href="https://www.genenames.org/tools/search/#!/genes?query=HLA-A" class="mim-tip-hint" title="HUGO Gene Nomenclature Committee." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HGNC', 'domain': 'genenames.org'})">HLA-A</a></em></strong>
|
|
</span>
|
|
</p>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
<div>
|
|
<a id="cytogeneticLocation" class="mim-anchor"></a>
|
|
<p>
|
|
<span class="mim-text-font">
|
|
<strong>
|
|
<em>
|
|
Cytogenetic location: <a href="/geneMap/6/229?start=-3&limit=10&highlight=229">6p22.1</a>
|
|
|
|
Genomic coordinates <span class="small">(GRCh38)</span> : <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&position=chr6:29942532-29945870&dgv=pack&knownGene=pack&omimGene=pack" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">6:29,942,532-29,945,870</a> </span>
|
|
</em>
|
|
</strong>
|
|
<a href="https://www.ncbi.nlm.nih.gov/" target="_blank" class="small"> (from NCBI) </a>
|
|
|
|
|
|
|
|
</span>
|
|
</p>
|
|
</div>
|
|
|
|
|
|
<div>
|
|
<br />
|
|
</div>
|
|
<div>
|
|
<a id="geneMap" class="mim-anchor"></a>
|
|
<div style="margin-bottom: 10px;">
|
|
<span class="h4 mim-font">
|
|
<strong>Gene-Phenotype Relationships</strong>
|
|
</span>
|
|
</div>
|
|
<div>
|
|
<table class="table table-bordered table-condensed table-hover small mim-table-padding">
|
|
<thead>
|
|
<tr class="active">
|
|
<th>
|
|
Location
|
|
</th>
|
|
<th>
|
|
Phenotype
|
|
|
|
</th>
|
|
<th>
|
|
Phenotype <br /> MIM number
|
|
</th>
|
|
<th>
|
|
Inheritance
|
|
</th>
|
|
<th>
|
|
Phenotype <br /> mapping key
|
|
</th>
|
|
</tr>
|
|
</thead>
|
|
<tbody>
|
|
|
|
<tr>
|
|
<td rowspan="1">
|
|
<span class="mim-font">
|
|
<a href="/geneMap/6/229?start=-3&limit=10&highlight=229">
|
|
6p22.1
|
|
</a>
|
|
</span>
|
|
</td>
|
|
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<p>The human major histocompatibility complex (MHC) has been divided into 3 regions on chromosome 6p21.3: class II (centromeric), class III, and class I (telomeric), with extended class I and class II regions on either side. The MHC encodes highly polymorphic proteins, many of which are associated with the immune system. The products of classical polymorphic class I genes, human leukocyte antigen-A (HLA-A), HLA-B (<a href="/entry/142830">142830</a>), and HLA-C (<a href="/entry/142840">142840</a>), interact with T-cell receptor (TCR; see <a href="/entry/186880">186880</a>) molecules, as well as killer immunoglobulin-like receptors (KIRs; see <a href="/entry/604936">604936</a>) expressed on natural killer cells and some T cells (review by <a href="#111" class="mim-tip-reference" title="Trowsdale, J. <strong>Genetic and functional relationships between MHC and NK receptor genes.</strong> Immunity 15: 363-374, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11567627/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11567627</a>] [<a href="https://doi.org/10.1016/s1074-7613(01)00197-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11567627">Trowsdale, 2001</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11567627" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Evidence from amino acid sequences suggests an evolutionary relatedness of transplantation antigens, immunoglobulins and beta-2-microglobins (<a href="#109" class="mim-tip-reference" title="Tragardh, L., Rask, L., Wiman, K., Fohlman, J., Peterson, P. A. <strong>Amino acid sequence of an immunoglobulin HLA antigen heavy chain domain.</strong> Proc. Nat. Acad. Sci. 76: 5839-5842, 1979.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/118453/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">118453</a>] [<a href="https://doi.org/10.1073/pnas.76.11.5839" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="118453">Tragardh et al., 1979</a>). Both the class I MHC antigens (A, B, and C) and the class II antigens DR and DC1 are polymorphic 2-chain cell surface glycoproteins; they are recognized by different subsets of T cells and have different functions, tissue distributions, and structures. The light chain of class I antigens is beta-2-microglobulin (B2M; <a href="/entry/109700">109700</a>), which is coded by chromosome 15. The heavy chain, coded by chromosome 6, has a molecular mass of 44,000 and is made up of 3 N-terminal extracellular domains of 90 amino acids each, a small hydrophobic membrane-spanning segment and a small hydrophilic intracellular C-terminal domain. The 2 N-terminal domains are polymorphic, bear the carbohydrate and have no sequence homology with immunoglobulin. The third domain, closest to the membrane, and the 11.6-kD B2M light chain are highly conserved and have strong sequence homology with immunoglobulin. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=118453" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>The sequence of a human class I gene was determined by <a href="#77" class="mim-tip-reference" title="Malissen, M., Malissen, B., Jordan, B. R. <strong>Exon/intron organization and complete nucleotide sequence of an HLA gene.</strong> Proc. Nat. Acad. Sci. 79: 893-897, 1982.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6461010/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6461010</a>] [<a href="https://doi.org/10.1073/pnas.79.3.893" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="6461010">Malissen et al. (1982)</a>. As in mouse, the domain organization of the HLA protein is reflected precisely in the exon-intron structure of the gene: separate exons encode the signal peptide, each of the 3 external domains and the transmembrane region, and 3 exons encode the small cytoplasmic domain. (See <a href="#54" class="mim-tip-reference" title="Hood, L., Steinmetz, M., Goodenow, R. <strong>Genes of the major histocompatibility complex.</strong> Cell 28: 685-687, 1982.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6284368/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6284368</a>] [<a href="https://doi.org/10.1016/0092-8674(82)90046-0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="6284368">Hood et al., 1982</a>.) <a href="https://pubmed.ncbi.nlm.nih.gov/?term=6461010+6284368" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>Studying a family with a pericentric inversion, <a href="#65" class="mim-tip-reference" title="Lamm, L. U., Friedrich, U., Petersen, G. B., Jorgensen, J., Nielsen, J., Therkelsen, A. J., Kissmeyer-Nielsen, F. <strong>Assignment of the major histocompatibility complex to chromosome no. 6 in a family with a pericentric inversion.</strong> Hum. Hered. 24: 273-284, 1974.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4435793/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4435793</a>] [<a href="https://doi.org/10.1159/000152660" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4435793">Lamm et al. (1974)</a> confirmed assignment of the HLA complex to chromosome 6. In a familial 6-21 translocation (<a href="#20" class="mim-tip-reference" title="Borgaonkar, D. S., Bias, W. B., Chase, G. A., Sadasivan, G., Herr, H. M., Golomb, H. M., Bahr, G. F., Kunkel, L. M. <strong>Identification of C6-G21 translocation chromosome by the Q-M and Giemsa banding techniques in a patient with Down's syndrome, with possible assignment of Gm locus.</strong> Clin. Genet. 4: 53-57, 1973.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4120631/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4120631</a>] [<a href="https://doi.org/10.1111/j.1399-0004.1973.tb01122.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4120631">Borgaonkar et al., 1973</a>), <a href="#21" class="mim-tip-reference" title="Borgaonkar, D. S., Bias, W. B. <strong>HL-A loci and chromosome 6.</strong> Birth Defects Orig. Art. Ser. X(3): 67-68, 1974."None>Borgaonkar and Bias (1974)</a> could show that HLA is proximal to 6p22. <a href="#43" class="mim-tip-reference" title="Francke, U., Pellegrino, M. A. <strong>Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.</strong> Proc. Nat. Acad. Sci. 74: 5776 only, 1977."None>Francke and Pellegrino (1977)</a> concluded that HLA is distal to 6p21. Thus, rather precise localization is possible. <a href="#64" class="mim-tip-reference" title="Kompf, J., Bissbort, S., Gohler, F., Schunter, F., Wernet, P. <strong>Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM. I. Recombination frequencies.</strong> Hum. Genet. 44: 313-319, 1978.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/730169/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">730169</a>] [<a href="https://doi.org/10.1007/BF00394296" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="730169">Kompf et al. (1978)</a> and <a href="#98" class="mim-tip-reference" title="Schunter, F., Wernet, P., Kompf, J., Bissbort, S., Gohler, F. <strong>Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM. II. Segregation analysis.</strong> Hum. Genet. 44: 321-331, 1978.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/730170/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">730170</a>] [<a href="https://doi.org/10.1007/BF00394297" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="730170">Schunter et al. (1978)</a> presented evidence suggesting that PGM3 (<a href="/entry/172100">172100</a>) is on the HLA-A side of MHC rather than on the HLA-B side, as had previously been thought. From study of a 3-generation family segregating for variation of the centromeric heterochromatic region of chromosome 6p11 (6ph), <a href="#10" class="mim-tip-reference" title="Bakker, E., Pearson, P. L., Meera Khan, P., Schreuder, G. M. T., Madan, K. <strong>Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6.</strong> Clin. Genet. 15: 198-202, 1979.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/761421/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">761421</a>] [<a href="https://doi.org/10.1111/j.1399-0004.1979.tb01762.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="761421">Bakker et al. (1979)</a> concluded that the HLA cluster and 6ph are about 6 cM apart (with peak lod score of 3.466 at a recombination fraction of 0.0588; 95% confidence limits 0-0.18), that GLO is on the centromeric side of HLA, that PGM-3 is not on the short arm, and that HLA-B is closer to the centromere than HLA-A. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=4120631+4435793+730170+730169+761421" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a child partially trisomic for chromosome 6, <a href="#13" class="mim-tip-reference" title="Berger, R., Bernheim, A., Sasportes, M., Hauptmann, G., Hors, J., Legrand, L., Fellous, M. <strong>Regional mapping of the HLA on the short arm of chromosome 6.</strong> Clin. Genet. 15: 245-251, 1979.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/84721/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">84721</a>] [<a href="https://doi.org/10.1111/j.1399-0004.1979.tb00975.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="84721">Berger et al. (1979)</a> discovered 3 haplotypes for HLA-A, -B and -C from the mother. The patient had only 2 HLA-DR specificities. The region was assigned to 6p2105. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=84721" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>By in situ hybridization, <a href="#83" class="mim-tip-reference" title="Morton, C. C., Kirsch, I. R., Nance, W. E., Evans, G. A., Korman, A. J., Strominger, J. L. <strong>Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization.</strong> Proc. Nat. Acad. Sci. 81: 2816-2820, 1984.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6585830/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6585830</a>] [<a href="https://doi.org/10.1073/pnas.81.9.2816" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="6585830">Morton et al. (1984)</a> showed that class I HLA determinants (HLA-A, -B, -C) are located in 6p21.3 and class II determinants in 6p21.1. The findings suggested that one can resolve loci separated by as little as 1 cM by this technique. Using C-band heteromorphisms in linkage studies, <a href="#93" class="mim-tip-reference" title="Polacek, L. A., Phillips, R. B., Hackbarth, S. A., Duquesnoy, R. J. <strong>A linkage study of the HLA region using C-band heteromorphisms.</strong> Clin. Genet. 23: 177-185, 1983.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6851213/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6851213</a>] [<a href="https://doi.org/10.1111/j.1399-0004.1983.tb01869.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="6851213">Polacek et al. (1983)</a> estimated the centromere-HLA distance as 14 cM with 95% confidence limits of 0.012 and 0.263. Reference to the chiasma map of <a href="#84" class="mim-tip-reference" title="Morton, N. E., Rao, D. C., Lindsten, J., Hulten, M., Yee, S. <strong>A chiasma map of man.</strong> Hum. Hered. 27: 38-51, 1977.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/844885/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">844885</a>] [<a href="https://doi.org/10.1159/000152850" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="844885">Morton et al. (1977)</a> suggested that a map distance of 14 cM corresponds to 6p21-6p22, the region where HLA is mapped physically. <a href="#85" class="mim-tip-reference" title="Mulley, J. C., Hay, J., Sheffield, L. J., Sutherland, G. R. <strong>Regional localization for HLA by recombination with a fragile site at 6p23.</strong> Am. J. Hum. Genet. 35: 1284-1288, 1983.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6650505/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6650505</a>]" pmid="6650505">Mulley et al. (1983)</a> estimated that the genetic distance of HLA from fragile site 6p23 is 20 cM, with a lower 95% probability limit of 8.5 cM, placing HLA proximal to the midpoint of 6p22. This agreed closely with the other regionalization of HLA at 6p21.3. The work suggests that the fragile site does not distort recombination and that the genetic determinant predisposing to expression of the fragile site is situated at the fragile site. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=844885+6851213+6650505+6585830" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>By FISH, <a href="#53" class="mim-tip-reference" title="Hirai, M., Takahashi, E., Ishida, T., Hori, T. <strong>Chromosomal localization of the major histocompatibility complex (MHC) in the rhesus monkey and chimpanzee by fluorescence in situ hybridization.</strong> Cytogenet. Cell Genet. 57: 204-205, 1991.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1743075/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1743075</a>] [<a href="https://doi.org/10.1159/000133147" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1743075">Hirai et al. (1991)</a> placed the MHC loci on 5p21.3 in the chimpanzee, which corresponds precisely to their location on human chromosome 6p21.3. The chimpanzee has 48 chromosomes with 2 pairs of group D-like chromosomes which, in the human, are represented by the 2 arms of chromosome 2. The MHC loci were shown by <a href="#53" class="mim-tip-reference" title="Hirai, M., Takahashi, E., Ishida, T., Hori, T. <strong>Chromosomal localization of the major histocompatibility complex (MHC) in the rhesus monkey and chimpanzee by fluorescence in situ hybridization.</strong> Cytogenet. Cell Genet. 57: 204-205, 1991.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1743075/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1743075</a>] [<a href="https://doi.org/10.1159/000133147" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1743075">Hirai et al. (1991)</a> to be located on the long arm of the rhesus monkey chromosome 5; by study of somatic cell hybrids, the MHC loci had been thought to be on chromosome 2 of the rhesus. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1743075" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>The T-locus in the mouse is on the same chromosome as the H-2 locus and is likewise highly complex in its genetics (<a href="#47" class="mim-tip-reference" title="Gluecksohn-Waelsch, S., Erickson, R. P. <strong>The T-locus of the mouse: implications for mechanisms of development.</strong> Curr. Top. Dev. Biol. 5: 281-316, 1970.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4120274/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4120274</a>] [<a href="https://doi.org/10.1016/s0070-2153(08)60058-7" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4120274">Gluecksohn-Waelsch and Erickson, 1970</a>). The linkage of the T and H-2 loci may have significance since the T-locus is concerned with development, and surface antigens of the sort coded by H-2 (and HLA) are also important in development. The MHC antigens are differentiation antigens. Because of the close homologies, information on MHC of the mouse is of great relevance (<a href="#63" class="mim-tip-reference" title="Klein, J. <strong>The major histocompatibility complex of the mouse.</strong> Science 203: 516-521, 1979.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/104386/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">104386</a>] [<a href="https://doi.org/10.1126/science.104386" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="104386">Klein, 1979</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?term=4120274+104386" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#71" class="mim-tip-reference" title="Lawrance, S. K., Smith, C. L., Srivastava, R., Cantor, C. R., Weissman, S. M. <strong>Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis.</strong> Science 235: 1387-1390, 1987.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3029868/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3029868</a>] [<a href="https://doi.org/10.1126/science.3029868" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3029868">Lawrance et al. (1987)</a> demonstrated the feasibility of megabase-scale mapping of the HLA gene complex by pulsed-field gel electrophoresis. With previous methods, there existed a 'resolution gap' between molecular cloning experiments and meiotic linkage analyses. The enzymes used in the study were initially selected as those which recognize 8-basepair cleavage sites and/or contain CpG in their recognition sequences. Because of the rarity of CpG in mammalian genomes, these enzymes are expected to generate fragments that are much larger than would be predicted statistically in random sequence DNA. Enzyme restriction endonucleases used were NotI, SalI, and NruI. The data indicated that the HLA complex spans over 3 million bases (<a href="#95" class="mim-tip-reference" title="Ragoussis, J., van der Bliek, A., Trowsdale, J., Ziegler, A. <strong>Mapping of HLA genes using pulsed field gradient electrophoreses.</strong> FEBS Lett. 204: 1-4, 1986.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3743756/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3743756</a>] [<a href="https://doi.org/10.1016/0014-5793(86)81376-x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3743756">Ragoussis et al., 1986</a>; <a href="#71" class="mim-tip-reference" title="Lawrance, S. K., Smith, C. L., Srivastava, R., Cantor, C. R., Weissman, S. M. <strong>Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis.</strong> Science 235: 1387-1390, 1987.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3029868/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3029868</a>] [<a href="https://doi.org/10.1126/science.3029868" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3029868">Lawrance et al., 1987</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?term=3029868+3743756" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>To avoid problems of interpretation resulting from heterozygosity, <a href="#94" class="mim-tip-reference" title="Ragoussis, J., Bloemer, K., Pohla, H., Messer, G., Weiss, E. H., Ziegler, A. <strong>A physical map including a new class I gene (cda12) of the human major histocompatibility complex (A2/B13 haplotype) derived from a monosomy 6 mutant cell line.</strong> Genomics 4: 301-308, 1989.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2497062/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2497062</a>] [<a href="https://doi.org/10.1016/0888-7543(89)90334-0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="2497062">Ragoussis et al. (1989)</a> used a monosomy 6 mutant cell line to establish a molecular map of the MHC region. Field-inversion gel electrophoresis and Southern blotting techniques were used. The HLA complex has a length of 4,200 kb. Five HTF islands were positioned on the map: between DX (HLA-DQA1; <a href="/entry/613503">613503</a>) and DOB, close to DOB; between DRA and C4; between C2 and TNFA, close to C2; within 50 kb telomeric to HLA-C; and within 200 kb telomeric to HLA-A. The total length of the MHC region represents about 2.5% of the total length of chromosome 6. The class I region has a size of about 2,000 kb. The class II region has a size of 1,000 kb and is separated from the class I region by about 1,200 kb. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2497062" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#124" class="mim-tip-reference" title="Ziegler, A., Ragoussis, J., Fonatsch, C., Weiss, E. <strong>A physical map of the human major histocompatibility (HLA) complex derived from a monosomy 6 mutant cell line. (Abstract)</strong> Cytogenet. Cell Genet. 51: 1116 only, 1989."None>Ziegler et al. (1989)</a> presented a physical map of the human MHC locus derived from pulsed field gel electrophoresis data.</p><p><a href="#110" class="mim-tip-reference" title="Trowsdale, J., Ragoussis, J., Campbell, R. D. <strong>Map of the human MHC.</strong> Immun. Today 12: 443-446, 1991.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1786080/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1786080</a>] [<a href="https://doi.org/10.1016/0167-5699(91)90017-n" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1786080">Trowsdale et al. (1991)</a> and <a href="#25" class="mim-tip-reference" title="Campbell, R. D., Trowsdale, J. <strong>Map of the human MHC.</strong> Immun. Today 14: 349-352, 1993.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8363724/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8363724</a>] [<a href="https://doi.org/10.1016/0167-5699(93)90234-C" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8363724">Campbell and Trowsdale (1993)</a> provided maps compiling the physical mapping and cloning data related to the entire MHC region of the human. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=8363724+1786080" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#1" class="mim-tip-reference" title="Abderrahim, H., Sambucy, J.-L., Iris, F., Ougen, P., Billault, A., Chumakov, I. M., Dausset, J., Cohen, D., Le Paslier, D. <strong>Cloning the human major histocompatibility complex in YACs.</strong> Genomics 23: 520-527, 1994.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7851878/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7851878</a>] [<a href="https://doi.org/10.1006/geno.1994.1538" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7851878">Abderrahim et al. (1994)</a> isolated 53 YACs with an average size of 490 kb and organized them into a single large contig covering more than 4,000 kb spanning the entire MHC region. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7851878" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><strong><em>Class I HLA Pseudogenes</em></strong></p><p>
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HLA-H is a class I HLA pseudogene. (The designation HLAH, rather than HFE (<a href="/entry/613609">613609</a>), has been used by some for the gene mutant in hereditary hemochromatosis (<a href="/entry/235200">235200</a>). HLAHP may an appropriate symbol for this presumed pseudogene, thus avoiding confusion.) By a combination of cosmid cloning, chromosomal jumping, and pulsed field gel electrophoresis (PFGE), <a href="#101" class="mim-tip-reference" title="Shukla, H., Gillespie, G. A., Srivastava, R., Collins, F., Chorney, M. J. <strong>A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC.</strong> Genomics 10: 905-914, 1991.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1916822/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1916822</a>] [<a href="https://doi.org/10.1016/0888-7543(91)90178-h" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1916822">Shukla et al. (1991)</a> performed fine mapping of the HLA-A subregion of the major histocompatibility complex. They demonstrated that the Qa-like HLA-G class I gene (<a href="/entry/142871">142871</a>) is within 100 kb of HLA-H. Furthermore, these 2 genes are linked to HLA-A, with HLA-H lying no more than 200 kb from HLA-A. The data were interpreted as supporting the existence of a Qa-like subregion composed of nonclassic HLA class I genes within the human MHC and situated telomeric to the HLA-A locus. HLA-H is probably a pseudogene due to an in-frame termination codon in its fourth exon; however, at the RNA level, the gene is expressed. The human Qa-like subregion appears to be less densely populated with genes than is its mouse equivalent. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1916822" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>HLA-J is another class I HLA pseudogene. Nucleotide sequence comparisons show that the HLA-A, H, J, and G genes form a well-defined group of 'HLA-A-related' loci (<a href="#82" class="mim-tip-reference" title="Messer, G., Zemmour, J., Orr, H. T., Parham, P., Weiss, E. H., Girdlestone, J. <strong>HLA-J, a second inactivated class I HLA gene related to HLA-G and HLA-A.</strong> J. Immun. 148: 4043-4053, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1602142/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1602142</a>]" pmid="1602142">Messer et al., 1992</a>). Evolutionary relationships suggested that the 4 modern loci were formed by successive duplications from a common ancestral gene. It is thought that one intermediate locus gives rise to A and H, the other to G and J. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1602142" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#19" class="mim-tip-reference" title="Bodmer, W. F. <strong>Personal Communication.</strong> London, England 9/26/1986."None>Bodmer (1986)</a> suggested that the gene products of the major histocompatibility complex be referred to as histoglobulins, a term parallel to immunoglobulins, with which they share an evolutionary origin. The chimpanzee has 2 main allelic series of leukocyte antigens (<a href="#11" class="mim-tip-reference" title="Balner, H., D'Amaro, J., Visser, T. P. <strong>Tissue typing of chimpanzees: I. Evidence for two allelic series of leukocyte antigens.</strong> Transplant. Proc. 6: 141-149, 1974.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4831531/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4831531</a>]" pmid="4831531">Balner et al., 1974</a>) and the Rhesus monkey has histocompatibility-linked immune-response genes (<a href="#37" class="mim-tip-reference" title="Dorf, M. E., Balner, H., DeGroot, M. L., Benacerraf, B. <strong>Histocompatibility-linked immune-response genes in the Rhesus monkey.</strong> Transplant. Proc. 6: 119-124, 1974.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4208749/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4208749</a>]" pmid="4208749">Dorf et al., 1974</a>). The existence of one or more Ir (immune response) loci in man is suggested by the comparative studies of the MHC of mice and lower primates; furthermore, 2 separate loci in the MHC code for B-lymphocyte alloantigens (see <a href="/entry/146880">146880</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?term=4831531+4208749" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#62" class="mim-tip-reference" title="Klein, J., Figueroa, F. <strong>Evolution of the major histocompatibility complex.</strong> CRC Crit. Rev. Immun. 6: 295-386, 1986.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3536303/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3536303</a>]" pmid="3536303">Klein and Figueroa (1986)</a> reviewed the evolution of the major histocompatibility complex, using the designation Mhc for the mouse system. They reproduced the figure of the banding pattern of mouse chromosomes as revealed by Giemsa staining following treatment with trypsin and chymotrypsin. They concluded that the Mhc region represents a 'frozen linkage group;' that the complement and P-450 genes were transferred to the Mhc region from another chromosome at the time the beta-2-microglobulin gene separated from the Mhc cluster and that they are therefore foreign elements in the Mhc region and not functional parts of Mhc proper; and that class Ib loci (Qa and Tla) constitute the junkyard of the Mhc region, these being either pseudogenes or on the way to becoming pseudogenes. <a href="#42" class="mim-tip-reference" title="Figueroa, F., Gunther, E., Klein, J. <strong>MHC polymorphism pre-dating speciation. (Letter)</strong> Nature 335: 265-267, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3137477/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3137477</a>] [<a href="https://doi.org/10.1038/335265a0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3137477">Figueroa et al. (1988)</a> described MHC polymorphism that must have arisen before the separation of mice and rats from a common ancestor more than 10 million years ago. Similarly, <a href="#70" class="mim-tip-reference" title="Lawlor, D. A., Ward, F. E., Ennis, P. D., Jackson, A. P., Parham, P. <strong>HLA-A and B polymorphisms predate the divergence of humans and chimpanzees. (Letter)</strong> Nature 335: 268-271, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3412487/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3412487</a>] [<a href="https://doi.org/10.1038/335268a0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3412487">Lawlor et al. (1988)</a> found close similarity in the HLA-A and HLA-B (<a href="/entry/142830">142830</a>) alleles of human and chimpanzee. Indeed, individual alleles were found to be more closely related to individual chimpanzee alleles than to other HLA-A or -B alleles. Thus, again, a considerable proportion of contemporary HLA-A and -B polymorphism existed before divergence of the chimpanzee and human lines. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=3137477+3412487+3536303" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>MHC class I molecules play an essential role in the immune defense against intracellular infections. The hallmark of the MHC is its extensive degree of polymorphism at the population level. However, <a href="#36" class="mim-tip-reference" title="de Groot, N. G., Otting, N., Doxiadis, G. G. M., Balla-Jhagjhoorsingh, S. S., Heeney, J. L., van Rood, J. J., Gagneux, P., Bontrop, R. E. <strong>Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees.</strong> Proc. Nat. Acad. Sci. 99: 11748-11753, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12186979/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12186979</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=12186979[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1073/pnas.182420799" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12186979">de Groot et al. (2002)</a>, comparing MHC class I gene intron variation, found that chimpanzees have experienced a severe repertoire reduction at the orthologs of the HLA-A, -B, and -C loci. The loss of variability predated the (sub)speciation of chimpanzees and did not affect other known gene systems. Therefore, the selective sweep in the MHC class I gene may have resulted from a widespread viral infection. Based on their results and the fact that chimpanzees have a natural resistance to the development of AIDS, <a href="#36" class="mim-tip-reference" title="de Groot, N. G., Otting, N., Doxiadis, G. G. M., Balla-Jhagjhoorsingh, S. S., Heeney, J. L., van Rood, J. J., Gagneux, P., Bontrop, R. E. <strong>Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees.</strong> Proc. Nat. Acad. Sci. 99: 11748-11753, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12186979/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12186979</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=12186979[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1073/pnas.182420799" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12186979">de Groot et al. (2002)</a> hypothesized that the selective sweep was caused by the chimpanzee-derived simian immunodeficiency virus, the closest relative of HIV-1, or a closely related retrovirus. Hence, contemporary chimpanzee populations represent the offspring of AIDS-resistant animals, the survivors of an HIV-like pandemic that took place in the distant past. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12186979" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#31" class="mim-tip-reference" title="Danchin, E. G. J., Abi-Rached, L., Gilles, A., Pontarotti, P. <strong>Conservation of the MHC-like region throughout evolution.</strong> Immunogenetics 55: 141-148, 2003.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12734695/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12734695</a>] [<a href="https://doi.org/10.1007/s00251-003-0562-0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12734695">Danchin et al. (2003)</a> claimed to have confirmed for the first time with robust evidence the existence of a region of conserved synteny between the human genome and the Drosophila genome. Evolutionarily conserved synteny involved the human MHC and paralogous regions. The authors identified 19 conserved genes between these 2 species in a Drosophila genomic region of less than 2 Mb. The statistical analysis of the distribution of these 19 genes between the 2 genomes showed that it could not be explained by chance. <a href="#31" class="mim-tip-reference" title="Danchin, E. G. J., Abi-Rached, L., Gilles, A., Pontarotti, P. <strong>Conservation of the MHC-like region throughout evolution.</strong> Immunogenetics 55: 141-148, 2003.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12734695/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12734695</a>] [<a href="https://doi.org/10.1007/s00251-003-0562-0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12734695">Danchin et al. (2003)</a> suggested that their study constituted a first step toward the reconstruction of the genome of Urbilateria (the ancestor of all bilaterians) and allowed for a better understanding of the evolutionary history of the human genome as well as other metazoan genomes. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12734695" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>The usefulness of HLA typing for selection of kidney donors was demonstrated by <a href="#91" class="mim-tip-reference" title="Patel, R., Mickey, M. R., Terasaki, P. I. <strong>Serotyping for homotransplantation of kidneys from unrelated donors.</strong> New Eng. J. Med. 279: 501-506, 1968.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4876470/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4876470</a>] [<a href="https://doi.org/10.1056/NEJM196809052791001" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4876470">Patel et al. (1968)</a>. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4876470" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#97" class="mim-tip-reference" title="Salter, R. D., Norment, A. M., Chen, B. P., Clayberger, C., Krensky, A. M., Littman, D. R., Parham, P. <strong>Polymorphism in the alpha(3) domain of HLA-A molecules affects binding to CD8.</strong> Nature 338: 345-347, 1989.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2784196/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2784196</a>] [<a href="https://doi.org/10.1038/338345a0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="2784196">Salter et al. (1989)</a> demonstrated that the binding of CD8 (<a href="/entry/186910">186910</a>) glycoprotein on the surface of cytotoxic T-lymphocytes is mediated through the alpha-3 domain of class I MHC molecules. They demonstrated that 2 HLA-A alleles, which do not bind CD8, have a valine for alanine substitution at position 245. Further studies using site-directed mutagenesis demonstrated that this substitution in the alpha-3 domain mediates the CD8 binding. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2784196" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Although the major histocompatibility complex (MHC) is named for its association with graft rejection, clearly the prevention of tissue engraftment between individuals is not the raison d'etre for MHC-encoded molecules. Through the progress of knowledge concerning MHC and the evolution of concepts over a period of more than 50 years (see outline by <a href="#30" class="mim-tip-reference" title="Colombani, J. <strong>Changing the name of the major histocompatibility complex.</strong> Res. Immun. 143: 411-417, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1518955/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1518955</a>] [<a href="https://doi.org/10.1016/s0923-2494(05)80073-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1518955">Colombani, 1992</a>), it is now recognized that the products of the MHC genes are antigen-presenting molecules (APM) designed for the presentation of antigen fragments (peptides) to the T-cell receptor, thus participating in the immune response (<a href="#51" class="mim-tip-reference" title="Hedrick, S. M. <strong>Dawn of the hunt for nonclassical MHC function.</strong> Cell 70: 177-180, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1322246/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1322246</a>] [<a href="https://doi.org/10.1016/0092-8674(92)90092-q" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1322246">Hedrick, 1992</a>). Indeed, <a href="#30" class="mim-tip-reference" title="Colombani, J. <strong>Changing the name of the major histocompatibility complex.</strong> Res. Immun. 143: 411-417, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1518955/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1518955</a>] [<a href="https://doi.org/10.1016/s0923-2494(05)80073-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1518955">Colombani (1992)</a> suggested that instead of MHC the complex should be called MPHC, for major presentation and histocompatibility complex. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=1322246+1518955" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>MHC class I molecules present peptides that are derived from endogenous proteins. These antigens can also be transferred to professional antigen-presenting cells in a process called crosspresentation, which precedes initiation of a proper T-cell response. <a href="#86" class="mim-tip-reference" title="Neijssen, J., Herberts, C., Drijfhout, J. W., Reits, E., Janssen, L., Neefjes, J. <strong>Cross-presentation by intercellular peptide transfer through gap junctions.</strong> Nature 434: 83-88, 2005.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15744304/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15744304</a>] [<a href="https://doi.org/10.1038/nature03290" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15744304">Neijssen et al. (2005)</a> tested whether peptides can be transferred directly from the cytoplasm of one cell into the cytoplasm of its neighbor through gap junctions. They demonstrated that peptides with a molecular mass of up to approximately 1,800 diffuse intercellularly through gap junctions unless a 3-dimensional structure is imposed. This intercellular peptide transfer causes cytotoxic T-cell recognition of adjacent, innocent bystander cells as well as activated monocytes. Gap junction-mediated peptide transfer is restricted to a few coupling cells owing to the high cytosolic peptidase activity. <a href="#86" class="mim-tip-reference" title="Neijssen, J., Herberts, C., Drijfhout, J. W., Reits, E., Janssen, L., Neefjes, J. <strong>Cross-presentation by intercellular peptide transfer through gap junctions.</strong> Nature 434: 83-88, 2005.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15744304/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15744304</a>] [<a href="https://doi.org/10.1038/nature03290" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15744304">Neijssen et al. (2005)</a> presented a mechanism of antigen acquisition for crosspresentation that couples the antigen presentation system of 2 adjacent cells and is lost in most tumors: gap junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen-presenting cells for crosspriming. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15744304" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Transfusion-associated graft-versus-host disease (GVHD; see <a href="/entry/614395">614395</a>) is fatal in most cases. Since gamma irradiation of cellular blood components before transfusion can prevent the development of transfusion-associated GVHD, identification of susceptible hosts is critical. <a href="#100" class="mim-tip-reference" title="Shivdasani, R. A., Haluska, F. G., Dock, N. L., Dover, J. S., Kineke, E. J., Anderson, K. C. <strong>Graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors.</strong> New Eng. J. Med. 328: 766-770, 1993.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8437597/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8437597</a>] [<a href="https://doi.org/10.1056/NEJM199303183281105" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8437597">Shivdasani et al. (1993)</a> reported a case of transfusion-associated GVHD in the US that occurred after platelets from an HLA-homozygous donor, born of nonconsanguineous parents, were transfused into an immunocompetent patient who was heterozygous for the donor's haplotype. Because the likelihood that donors who are homozygous for a given HLA haplotype will provide blood for unrelated recipients who share that haplotype has been judged to be remote in the US, the general use of gamma irradiation of cellular blood components has not been recommended. <a href="#100" class="mim-tip-reference" title="Shivdasani, R. A., Haluska, F. G., Dock, N. L., Dover, J. S., Kineke, E. J., Anderson, K. C. <strong>Graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors.</strong> New Eng. J. Med. 328: 766-770, 1993.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8437597/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8437597</a>] [<a href="https://doi.org/10.1056/NEJM199303183281105" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8437597">Shivdasani et al. (1993)</a> suggested the existence of an HLA-related predisposition to transfusion-associated GVHD in immunocompetent patients and recommended that the guidelines for the irradiation of blood components be reassessed. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8437597" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Modulators of immune regulation 1 and 2 (MIR1 and MIR2) are E3 ubiquitin ligases encoded by Kaposi sarcoma-associated herpesvirus that mediate the ubiquitination of MHC I molecules and subsequent internalization. <a href="#24" class="mim-tip-reference" title="Cadwell, K., Coscoy, L. <strong>Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.</strong> Science 309: 127-130, 2005. Note: Erratum: Science 311: 177 only, 2006.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15994556/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15994556</a>] [<a href="https://doi.org/10.1126/science.1110340" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15994556">Cadwell and Coscoy (2005)</a> found that MIR1 but not MIR2 promoted downregulation of MHC I molecules lacking lysine residues in their intracytoplasmic domain. In the presence of MIR1, these MHC I molecules were ubiquitinated, and their association with ubiquitin was sensitive to beta-2-mercaptoethanol, unlike lysine-ubiquitin bonds. This form of ubiquitination required a cysteine residue in the intracytoplasmic tail of MHC I molecules. An MHC I molecule containing a single cysteine residue in an artificial glycine and alanine intracytoplasmic domain was endocytosed and degraded in the presence of MIR1. Thus, <a href="#24" class="mim-tip-reference" title="Cadwell, K., Coscoy, L. <strong>Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.</strong> Science 309: 127-130, 2005. Note: Erratum: Science 311: 177 only, 2006.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15994556/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15994556</a>] [<a href="https://doi.org/10.1126/science.1110340" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15994556">Cadwell and Coscoy (2005)</a> concluded that ubiquitination can occur on proteins lacking accessible lysines or an accessible N terminus. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15994556" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#96" class="mim-tip-reference" title="Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, MP., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., and 14 others. <strong>Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.</strong> Science 359: 86-90, 2018. Note: Erratum: Science 365 (6452) 2019.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/29302013/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">29302013</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=29302013[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1126/science.aam8825" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="29302013">Ramsuran et al. (2018)</a> analyzed 9,763 HIV-infected individuals from 21 cohorts and found that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E (<a href="/entry/143010">143010</a>), the ligand for the inhibitory NKG2A (see <a href="/entry/161555">161555</a>) natural killer cell receptor. HLA-B (<a href="/entry/142830">142830</a>) haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=29302013" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#69" class="mim-tip-reference" title="Lawlor, D. A., Dickel, C. D., Hauswirth, W. W., Parham, P. <strong>Ancient HLA genes from 7,500-year-old archaeological remains.</strong> Nature 349: 785-788, 1991.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2000147/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2000147</a>] [<a href="https://doi.org/10.1038/349785a0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="2000147">Lawlor et al. (1991)</a> used PCR to amplify brain DNA from the Windover pond of central Florida, which contains human remains about 7,500 years old. From 1 individual they characterized segments from 6 nuclear genes: that for beta-2-microglobulin and 5 members of the class I HLA heavy chain gene family. Distinctive patterns of nucleotide substitution in the cloned heavy chain gene segments permitted tentative assignment of the HLA-A,B type of the ancient individual. One of the HLA-A alleles that was found is observed at high frequency in the modern Amerindian population. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2000147" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#27" class="mim-tip-reference" title="Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., O'Brien, S. J. <strong>HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.</strong> Science 283: 1748-1752, 1999.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10073943/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10073943</a>] [<a href="https://doi.org/10.1126/science.283.5408.1748" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10073943">Carrington et al. (1999)</a> reported that the extended survival of 28 to 40% of HIV-1-infected Caucasian patients who avoided AIDS for 10 or more years (see <a href="/entry/609423">609423</a>) could be attributed to their being fully heterozygous at HLA class I loci, to lacking the AIDS-associated alleles B*35 and Cw*04, or to both. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10073943" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#76" class="mim-tip-reference" title="MacDonald, K. S., Fowke, K. R., Kimani, J., Dunand, V. A., Nagelkerke, N. J. D., Ball, T. B., Oyugi, J., Njagi, E., Gaur, L. K., Brunham, R. C., Wade, J., Luscher, M. A., Krausa, P., Rowland-Jones, S., Ngugi, E., Bwayo, J. J., Plummer, F. A. <strong>Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.</strong> J. Infect. Dis. 181: 1581-1589, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10823757/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10823757</a>] [<a href="https://doi.org/10.1086/315472" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10823757">MacDonald et al. (2000)</a> examined the influence of HLA types on susceptibility to HIV-1 infection in a population of chronically and highly exposed commercial sex workers enrolled in a prospective study in Nairobi, Kenya. MHC class I serologically defined alleles HLA-A2, HLA-A28, and HLA-B18 were associated with decreased risk of HIV-1 infection in this population, while HLA-A23 was associated with increased risk. Molecular subtyping identified a supertype, which consisted of the HLA-A2 subtypes HLA-A*0202, -A*0205, and -A*0214 and an HLA-A28 subtype, HLA-A*6802, that was associated with a significantly decreased rate of HIV-1 seroconversion. Molecular typing for MHC class II alleles revealed a significantly decreased risk of HIV-1 seroconversion associated with the HLA-DRB1*0102 allele of the HLA-DRB1*01 determinant. <a href="#76" class="mim-tip-reference" title="MacDonald, K. S., Fowke, K. R., Kimani, J., Dunand, V. A., Nagelkerke, N. J. D., Ball, T. B., Oyugi, J., Njagi, E., Gaur, L. K., Brunham, R. C., Wade, J., Luscher, M. A., Krausa, P., Rowland-Jones, S., Ngugi, E., Bwayo, J. J., Plummer, F. A. <strong>Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.</strong> J. Infect. Dis. 181: 1581-1589, 2000.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10823757/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10823757</a>] [<a href="https://doi.org/10.1086/315472" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="10823757">MacDonald et al. (2000)</a> noted that in this cohort resistance to HIV-1 infection was associated with immunologic responses to the virus but not with chemokine receptor polymorphisms (see CCR2; <a href="/entry/601267">601267</a>). They proposed that the A2/6802 supertype and the DRB1*01 determinant may mediate protection against HIV-1 through the presentation and restriction of conserved epitopes; however, these alleles are neither completely necessary nor sufficient for resistance. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10823757" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#105" class="mim-tip-reference" title="Szpak, Y., Vieville, J.-C., Tabary, T., Naud, M.-C., Chopin, M., Edelson, C., Cohen, J. H. M., Dausset, J., de Kozak, Y., Pla, M. <strong>Spontaneous retinopathy in HLA-A29 transgenic mice.</strong> Proc. Nat. Acad. Sci. 98: 2572-2576, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11226280/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11226280</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=11226280[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1073/pnas.051595998" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11226280">Szpak et al. (2001)</a> noted that the human MHC class I specificity HLA-A29 has been observed in nearly all patients (95.8%) with birdshot chorioretinopathy (BSCR; <a href="/entry/605808">605808</a>) compared with 7% in healthy controls. BSCR is characterized by multiple small, cream-colored lesions, symmetrically scattered mainly around the optic disc and radiating toward the equator. These depigmented spots, the most distinctive sign of the syndrome, appear at the level of the retinal pigment epithelium but, on occasion, suggest an even deeper infiltration. In an attempt to develop an animal model of HLA-A29-associated disease, <a href="#105" class="mim-tip-reference" title="Szpak, Y., Vieville, J.-C., Tabary, T., Naud, M.-C., Chopin, M., Edelson, C., Cohen, J. H. M., Dausset, J., de Kozak, Y., Pla, M. <strong>Spontaneous retinopathy in HLA-A29 transgenic mice.</strong> Proc. Nat. Acad. Sci. 98: 2572-2576, 2001.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11226280/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11226280</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=11226280[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1073/pnas.051595998" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11226280">Szpak et al. (2001)</a> produced transgenic mice expressing HLA-A29 molecules. They found that an eye disorder spontaneously arising in these transgenic mice included many of the features of HLA-A29-associated BSCR in humans. In humans the retinal vasculopathy and inflammatory signs associated with the funduscopic findings lead regularly to visual loss. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11226280" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#26" class="mim-tip-reference" title="Cardoso, C. S., Alves, H., Mascarenhas, M., Goncalves, R., Oliveira, P., Rodrigues, P., Cruz, E., de Sousa, M., Porto, G. <strong>Co-selection of the H63D mutation and the HLA-A29 allele: a new paradigm of linkage disequilibrium?</strong> Immunogenetics 53: 1002-1008, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11904676/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11904676</a>] [<a href="https://doi.org/10.1007/s00251-001-0414-8" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11904676">Cardoso et al. (2002)</a> found linkage disequilibrium between all HLA-A29-containing haplotypes and the hemochromatosis-producing H63D mutation (<a href="/entry/613609#0002">613609.0002</a>), favoring the hypothesis of a coselection of H63D and HLA-A29. They considered that support and insight were provided by the finding of significantly higher CD8+ T-lymphocyte counts in subjects simultaneously carrying the H63D mutation and the HLA-A29 allele. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11904676" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#123" class="mim-tip-reference" title="Zareparsi, S., James, D. M., Kaye, J. A., Bird, T. D., Schellenberg, G. D., Payami, H. <strong>HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease.</strong> Neurology 58: 973-975, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11914421/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11914421</a>] [<a href="https://doi.org/10.1212/wnl.58.6.973" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11914421">Zareparsi et al. (2002)</a> noted that several studies had found an increased frequency of the HLA-A2 allele in patients with early-onset Alzheimer disease (AD; <a href="/entry/104300">104300</a>) and that others had found an association between the A2 allele and earlier age of onset of AD. Among 458 unrelated patients with AD, <a href="#123" class="mim-tip-reference" title="Zareparsi, S., James, D. M., Kaye, J. A., Bird, T. D., Schellenberg, G. D., Payami, H. <strong>HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease.</strong> Neurology 58: 973-975, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11914421/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11914421</a>] [<a href="https://doi.org/10.1212/wnl.58.6.973" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="11914421">Zareparsi et al. (2002)</a> found that HLA-A2 homozygotes had an average 5-year earlier age of onset than either A2 heterozygotes or those without A2. The risk associated with the A2 homozygous genotype was 2.6 times greater in patients with early-onset AD (less than age 60) than in those with late-onset AD, reflecting a dosage effect. These effects were present regardless of gender, familial or sporadic nature of the disease, or presence or absence of the APOE (<a href="/entry/107741">107741</a>) E4 allele. The authors suggested that the A2 allele may have a role in regulating an immune response in the pathogenesis of AD or that there may be a responsible gene in close linkage to A2. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11914421" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a study of 40 Japanese patients with SJS/toxic epidermal necrolysis (TEN; <a href="/entry/608579">608579</a>) with ocular complications and 113 healthy Japanese individuals, <a href="#112" class="mim-tip-reference" title="Ueta, M., Sotozono, C., Tokunaga, K., Yabe, T., Kinoshita, S. <strong>Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese.</strong> Am. J. Ophthal. 143: 367-368, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17258541/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17258541</a>] [<a href="https://doi.org/10.1016/j.ajo.2006.09.029" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17258541">Ueta et al. (2007)</a> found a significant association with HLA-A*0206 (Pc less than .0005, OR = 5.1), but not with HLA-B, HLA-C, or other HLA-A alleles tested. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17258541" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Infectious mononucleosis (IM) is an immunopathologic disease caused by Epstein-Barr virus (EBV) that occurs in young adults and is a risk factor for Hodgkin lymphoma (<a href="/entry/236000">236000</a>). <a href="#80" class="mim-tip-reference" title="McAulay, K. A., Higgins, C. D., Macsween, K. F., Lake, A., Jarrett, R. F., Robertson, F. L., Williams, H., Crawford, D. H. <strong>HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection.</strong> J. Clin. Invest. 117: 3042-3048, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17909631/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17909631</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=17909631[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1172/JCI32377" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17909631">McAulay et al. (2007)</a> analyzed 2 microsatellite markers, D6S510 and D6S265, and 2 SNPs, <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs253088;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs253088</a> and <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs6457110;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs6457110</a>, from the HLA class I region in patients with acute IM and in asymptomatic EBV-seropositive and -seronegative individuals. Alleles of both microsatellite markers were significantly associated with development of IM, and allele A of <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs253088;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs253088</a> and allele T of <a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs6457110;toggle_HGVS_names=open" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'dbSNP\', \'domain\': \'ensembl.org\'})">rs6457110</a> were significantly more frequent in patients with IM than in EBV-seronegative individuals. IM patients with the associated microsatellite alleles had fewer lymphocytes, more neutrophils, and higher EBV titers than IM patients lacking the alleles. <a href="#80" class="mim-tip-reference" title="McAulay, K. A., Higgins, C. D., Macsween, K. F., Lake, A., Jarrett, R. F., Robertson, F. L., Williams, H., Crawford, D. H. <strong>HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection.</strong> J. Clin. Invest. 117: 3042-3048, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17909631/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17909631</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=17909631[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1172/JCI32377" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17909631">McAulay et al. (2007)</a> proposed that HLA class I polymorphisms predispose patients to development of IM upon primary EBV infection, possibly due to genetic variation in T-cell responses and the level of viral persistence. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17909631" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#87" class="mim-tip-reference" title="Nejentsev, S., Howson, J. M. M., Walker, N. M., Szesko, J., Field, S. F., Stevens, H. E., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, L. M., and 8 others. <strong>Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.</strong> Nature 450: 887-892, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18004301/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18004301</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=18004301[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature06406" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="18004301">Nejentsev et al. (2007)</a> used several large type I diabetes (<a href="/entry/222100">222100</a>) data sets to analyze a combined total of 1,729 polymorphisms, and applied statistical methods--recursive partitioning and regression--to pinpoint disease susceptibility to the MHC class I genes HLA-B (<a href="/entry/142830">142830</a>) and HLA-A (risk ratios greater than 1.5; P(combined) = 2.01 x 10(-19) and 2.35 x 10(-13), respectively) in addition to the established associations of the MHC class II genes HLA-DQB1 (<a href="/entry/604305">604305</a>) and HLA-DRB1 (<a href="/entry/142857">142857</a>). <a href="#87" class="mim-tip-reference" title="Nejentsev, S., Howson, J. M. M., Walker, N. M., Szesko, J., Field, S. F., Stevens, H. E., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, L. M., and 8 others. <strong>Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.</strong> Nature 450: 887-892, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18004301/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18004301</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=18004301[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature06406" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="18004301">Nejentsev et al. (2007)</a> suggested that other loci with smaller and/or rarer effects might also be involved, but to find these future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, <a href="#87" class="mim-tip-reference" title="Nejentsev, S., Howson, J. M. M., Walker, N. M., Szesko, J., Field, S. F., Stevens, H. E., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, L. M., and 8 others. <strong>Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.</strong> Nature 450: 887-892, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18004301/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18004301</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=18004301[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature06406" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="18004301">Nejentsev et al. (2007)</a> concluded that MHC class I-mediated events, principally involving HLA-B*39, contribute to the etiology of type I diabetes. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=18004301" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, the <a href="#56" class="mim-tip-reference" title="International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2. <strong>Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.</strong> Nature 476: 214-219, 2011.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/21833088/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">21833088</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=21833088[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature10251" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="21833088">International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2 (2011)</a> replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci for multiple sclerosis (<a href="/entry/126200">126200</a>). Within the MHC the <a href="#56" class="mim-tip-reference" title="International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2. <strong>Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.</strong> Nature 476: 214-219, 2011.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/21833088/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">21833088</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=21833088[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature10251" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="21833088">International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2 (2011)</a> refined the identity of the HLA-DRB1 risk alleles as DRB1*1501 (<a href="/entry/142857#0002">142857.0002</a>) and DRB1*1303, and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes were significantly overrepresented among those mapping close to identified loci and particularly implicated T helper cell differentiation in the pathogenesis of multiple sclerosis. The <a href="#56" class="mim-tip-reference" title="International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2. <strong>Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.</strong> Nature 476: 214-219, 2011.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/21833088/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">21833088</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=21833088[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature10251" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="21833088">International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2 (2011)</a> confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. HLA allele HLA*0201 has a combined odds ratio (OR) of 0.73 across independent populations of European descent. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=21833088" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#75" class="mim-tip-reference" title="Lutz, C. T. <strong>Human leukocyte antigen Bw4 and Bw6 epitopes recognized by antibodies and natural killer cells.</strong> Curr. Opin. Organ Transplant. 19: 436-441, 2014.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/24977435/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">24977435</a>] [<a href="https://doi.org/10.1097/MOT.0000000000000103" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="24977435">Lutz (2014)</a> reviewed HLA Bw4 and Bw6. As a result of transplantation, blood transfusion, or pregnancy, people are immunized and produce antibodies to 'private' epitopes, which are shared by few other HLA allele products, or 'public' epitopes, which are encoded by many HLA alleles. The most prominent public epitopes are Bw4 and Bw6. Either the Bw4 or the Bw6 epitope is expressed by virtually all HLA-B molecules, and Bw4 is also found on a few HLA-A proteins. <a href="#90" class="mim-tip-reference" title="Parham, P., Norman, P. J., Abi-Rached, L., Guethlein, L. A. <strong>Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.</strong> Phil. Trans. Roy. Soc. London B Biol. Sci. 367: 800-811, 2012.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/22312047/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">22312047</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=22312047[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1098/rstb.2011.0266" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="22312047">Parham et al. (2012)</a> reported that Bw4, along with HLA-A3, HLA-A11, HLA-C1, and HLA-C2, is a KIR (e.g., KIR3DL1; <a href="/entry/604946">604946</a>) ligand. <a href="#50" class="mim-tip-reference" title="Habegger de Sorrentino, A., Sinchi, J. L., Marinic, K., Lopez, R., Iliovich, E. <strong>KIR-HLA-A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina.</strong> Immunology 140: 273-279, 2013.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/23789883/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">23789883</a>] [<a href="https://doi.org/10.1111/imm.12137" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="23789883">Habegger de Sorrentino et al. (2013)</a> listed 14 HLA-B alleles and 4 HLA-A alleles expressing Bw4 epitopes. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=22312047+23789883+24977435" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><strong><em>Reviews</em></strong></p><p>
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<a href="#49" class="mim-tip-reference" title="Gruen, J. R., Nalabolu, S. R., Chu, T. W., Bowlus, C., Fan, W. F., Goei, V. L., Wei, H., Sivakamasundari, R., Liu, Y.-C., Xu, H. X., Parimoo, S., Nallur, G., Ajioka, R., Shukla, H., Bray-Ward, P., Pan, J., Weissman, S. M. <strong>A transcription map of the major histocompatibility complex (MHC) class I region.</strong> Genomics 36: 70-85, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8812418/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8812418</a>] [<a href="https://doi.org/10.1006/geno.1996.0427" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8812418">Gruen et al. (1996)</a> applied cDNA hybridization selection to 9 YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the major histocompatibility complex. In addition to class I genes and pseudogenes, they described over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these was a group of genes encoding proteins showing homology to the C-terminal sequences of butyrophilin and an additional group of zinc finger genes. <a href="#49" class="mim-tip-reference" title="Gruen, J. R., Nalabolu, S. R., Chu, T. W., Bowlus, C., Fan, W. F., Goei, V. L., Wei, H., Sivakamasundari, R., Liu, Y.-C., Xu, H. X., Parimoo, S., Nallur, G., Ajioka, R., Shukla, H., Bray-Ward, P., Pan, J., Weissman, S. M. <strong>A transcription map of the major histocompatibility complex (MHC) class I region.</strong> Genomics 36: 70-85, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8812418/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8812418</a>] [<a href="https://doi.org/10.1006/geno.1996.0427" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8812418">Gruen et al. (1996)</a> also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than had been appreciated. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8812418" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#99" class="mim-tip-reference" title="Shiina, T., Hosomichi, K., Inoko, H., Kulski, J. K. <strong>The HLA genomic loci map: expression, interaction, diversity and disease.</strong> J. Hum. Genet. 54: 15-39, 2009.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/19158813/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">19158813</a>] [<a href="https://doi.org/10.1038/jhg.2008.5" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="19158813">Shiina et al. (2009)</a> provided an extensive review of what they termed the 'HLA super-locus,' a genomic region on 6p21 that contains the 6 classical transplantation HLA genes and at least 132 protein coding genes that have important roles in the regulation of the immune system as well as some other fundamental molecular and cellular processes. The review included a tabulation of MHC monogenic and polygenic disease associations. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=19158813" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><strong><em>Major Histocompatibility Complex Database</em></strong></p><p>
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<a href="#88" class="mim-tip-reference" title="Newell, W. R., Trowsdale, J., Beck, S. <strong>MHCDB--database of the human MHC.</strong> Immunogenetics 40: 109-115, 1994.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8026859/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8026859</a>] [<a href="https://doi.org/10.1007/BF00188173" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="8026859">Newell et al. (1994)</a> described a database of the human major histocompatibility complex, MHCDB, which allows access, retrieval, and display of physical and genetic data relating to the human MHC. The contents of the database included: (1) location of over 100 genes and other markers; (2) location of over 250 YAC and cosmid clones; (3) 150 kb of genomic DNA sequence including full annotation (exon/intron boundaries, repeats, promoters, etc.); (4) cDNA sequences of currently known class I and class II alleles; and (5) accompanying descriptive data--references, comments, laboratory addresses, and so on. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8026859" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#106" class="mim-tip-reference" title="Teshima, T., Ordemann, R., Reddy, P., Gagin, S., Liu, C., Cooke, K. R., Ferrara, J. L. M. <strong>Acute graft-versus-host disease does not require alloantigen expression on host epithelium.</strong> Nature Med. 8: 575-581, 2002. Note: Erratum: Nature Med. 8: 1039 only, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12042807/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12042807</a>] [<a href="https://doi.org/10.1038/nm0602-575" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12042807">Teshima et al. (2002)</a> transferred bone marrow into irradiated wildtype and MHC class II-deficient recipient mice. Donors and recipients differed at only a single class II allele. The class II-knockout recipient chimeras, therefore, expressed class II only on hemopoietic cells or antigen-presenting cells (APCs). CD4+ T lymphocytes expressing CD25 (<a href="/entry/147730">147730</a>) and CD49 expanded in the wildtype but not the class II-null mice. Wildtype mice also had increased serum Ifng (<a href="/entry/147570">147570</a>). All wildtype but no knockout mice succumbed to acute graft-versus-host disease (GvHD) by day 7 after transplant. Other experiments showed that host APC, but not epithelial cell, class II alloantigens are sufficient to induce CD4+ T cell expansion, cytokine secretion, and lethal GvHD. Furthermore, blockade of inflammatory cytokines TNF (<a href="/entry/191160">191160</a>) and IL1B (<a href="/entry/147720">147720</a>) can block the effector phase of acute GvHD without blocking CD4 T cell expansion. Similarly, in mice lacking class I expression, host APC alloantigen expression is required for the development of CD8+ T lymphocyte-mediated GvHD. Fatal disease onset, but not target organ damage in surviving mice, is reduced in mice lacking epithelial cell class I expression. <a href="#106" class="mim-tip-reference" title="Teshima, T., Ordemann, R., Reddy, P., Gagin, S., Liu, C., Cooke, K. R., Ferrara, J. L. M. <strong>Acute graft-versus-host disease does not require alloantigen expression on host epithelium.</strong> Nature Med. 8: 575-581, 2002. Note: Erratum: Nature Med. 8: 1039 only, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12042807/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12042807</a>] [<a href="https://doi.org/10.1038/nm0602-575" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12042807">Teshima et al. (2002)</a> concluded that host APCs are sufficient in both activation and effector phases of acute GvHD and that alloantigen expression on target cells is not always required, particularly for CD4-mediated disease. They proposed that blockade of inflammatory cytokines could be beneficial in clinical bone marrow transplantation by preventing the toxicity of GvHD while allowing beneficial graft-versus-leukemia effects. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12042807" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#72" class="mim-tip-reference" title="Leinders-Zufall, T., Brennan, P., Widmayer, P., Chandramani S., P., Maul-Pavicic, A., Jager, M., Li, X.-H., Breer, H., Zufall, F., Boehm, T. <strong>MHC class I peptides as chemosensory signals in the vomeronasal organ.</strong> Science 306: 1033-1037, 2004.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15528444/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15528444</a>] [<a href="https://doi.org/10.1126/science.1102818" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="15528444">Leinders-Zufall et al. (2004)</a> showed that small peptides that serve as ligands for MHC class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal G-alpha-o- (<a href="/entry/139311">139311</a>) and V2R receptor (see <a href="/entry/605234">605234</a>)-expressing zone of the vomeronasal epithelium. In behaving mice, the same peptides function as individuality signals underlying mate recognition in the context of pregnancy block. MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15528444" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#104" class="mim-tip-reference" title="Strachan, T. <strong>Molecular genetics and polymorphism of class I HLA antigens.</strong> Brit. Med. Bull. 43: 1-14, 1987.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3315094/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3315094</a>] [<a href="https://doi.org/10.1093/oxfordjournals.bmb.a072166" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3315094">Strachan (1987)</a> reviewed the molecular genetics of class I HLA antigens. The genes for the classical HLA-A, -B, and -C heavy chains are members of a large multigene family of highly related sequences. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3315094" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#7" class="mim-tip-reference" title="Bach, F. H., Amos, D. B. <strong>Hu-1 major histocompatibility locus in man.</strong> Science 156: 1506-1508, 1967.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4887739/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4887739</a>] [<a href="https://doi.org/10.1126/science.156.3781.1506" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4887739">Bach and Amos (1967)</a> concluded that a single locus with 15 or more alleles controls reactivity in mixed leukocyte culture tests, and that genes at this locus also control most of the specificities measured by cytotoxic antiserums to leukocytes. This may be the major histocompatibility locus in man. <a href="#14" class="mim-tip-reference" title="Bernard, J. <strong>La decouverte du systeme principal d'histocompatibilite de l'homme. (Editorial)</strong> Presse Med. 75: 2369 only, 1967.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6060307/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6060307</a>]" pmid="6060307">Bernard (1967)</a> called discovery of the Hu-1 (now called HLA) system as important an event in biology as discovery of the ABO and Rh systems, perhaps more important. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=4887739+6060307" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>By gel filtration, <a href="#78" class="mim-tip-reference" title="Mann, D. L., Rogentine, G. N., Jr., Fahey, J. L., Nathenson, S. G. <strong>Molecular heterogeneity of human lymphoid (HL-A) alloantigens.</strong> Science 163: 1460-1462, 1969.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5773111/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5773111</a>] [<a href="https://doi.org/10.1126/science.163.3874.1460" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="5773111">Mann et al. (1969)</a> separated soluble preparations of HLA alloantigens into components having either 'LA' specificity or 'FOUR' specificity. This may indicate that the HLA 'locus' is a region with several different cistrons. Furthermore, family data indicate the existence of 2 'segregant series.' Antigens 1, 2, 3, 9, 10 and 11 are mutually exclusive members of one allelic series whereas a different array of antigens constitutes a second series (<a href="#8" class="mim-tip-reference" title="Bach, M. L., Bach, F. H. <strong>The genetics of histocompatibility.</strong> Hosp. Practice 5(8): 33-44, 1970."None>Bach and Bach, 1970</a>). The relation of the isoantigenic variants identified in human fibroblast cultures to the HLA system is not known. Both the HLA system in man and the H-2 system in mice seem to have haploid expression in sperm. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5773111" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Recombination has been observed within the HLA system (<a href="#17" class="mim-tip-reference" title="Bodmer, W. F., Bodmer, J. G., Tripp, M. <strong>Recombination between the LA and 4 loci of the HL-A system. In: Histocompatibility Testing 1970.</strong> Copenhagen: Munksgaard 1970. Pp. 187-191."None>Bodmer et al., 1970</a>). The LA and 'FOUR' loci are very closely linked (<a href="#61" class="mim-tip-reference" title="Kissmeyer-Nielsen, F., Thorsby, E. <strong>Human transplantation antigens.</strong> Transplant. Rev. 4: 1-176, 1970.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4110124/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4110124</a>]" pmid="4110124">Kissmeyer-Nielsen and Thorsby, 1970</a>). The ratio of female to male recombination fractions is 1.6 (<a href="#67" class="mim-tip-reference" title="Lamm, L. U., Svejgaard, A., Kissmeyer-Nielsen, F. <strong>Further evidence for PGM(3): HL-A is another linkage in man.</strong> Nature N.B. 231: 109-110, 1971.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5281183/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5281183</a>] [<a href="https://doi.org/10.1038/newbio231109a0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="5281183">Lamm et al., 1971</a>). The HLA loci are linked to the PGM3 locus, the distance being about 0.15 morgans in females (<a href="#67" class="mim-tip-reference" title="Lamm, L. U., Svejgaard, A., Kissmeyer-Nielsen, F. <strong>Further evidence for PGM(3): HL-A is another linkage in man.</strong> Nature N.B. 231: 109-110, 1971.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5281183/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5281183</a>] [<a href="https://doi.org/10.1038/newbio231109a0" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="5281183">Lamm et al., 1971</a>). <a href="#66" class="mim-tip-reference" title="Lamm, L. U., Kissmeyer-Nielsen, F., Svejgaard, A., Petersen, G. B., Thorsby, E., Mayr, W., Hogman, C. <strong>On the orientation of the HL-A region and the PGM(3) locus in the chromosome.</strong> Tissue Antigens 2: 205-214, 1972.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4668408/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4668408</a>] [<a href="https://doi.org/10.1111/j.1399-0039.1972.tb00137.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4668408">Lamm et al. (1972)</a> reviewed the evidence that the 'FOUR' and LA loci are about 1 centimorgan apart and presented evidence that the PGM-3 locus is on the 'FOUR' side of the HLA region. <a href="#58" class="mim-tip-reference" title="Kissmeyer-Nielsen, F., Jorgensen, F., Lamm, L. U. <strong>The HL-A system in clinical medicine.</strong> Johns Hopkins Med. J. 131: 385-400, 1972.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4117674/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4117674</a>]" pmid="4117674">Kissmeyer-Nielsen et al. (1972)</a> reviewed the genetics of HLA, including the close linkage of 'LA' and 'FOUR' and the linkage of HLA to other loci. An immune response locus (<a href="/entry/146880">146880</a>) is thought to be closely linked to the HLA locus or part of the HLA region. Studies of HLA antigens solubilized from cell membranes indicate that the products of the 2 loci reside on different molecules, and no firm association or bond between the 2 molecular products exists in the cell membrane. <a href="#103" class="mim-tip-reference" title="Solheim, B. G., Bratlie, A., Sandberg, L., Staub-Nielsen, L., Thorsby, E. <strong>Further evidence of a third HL-A locus.</strong> Tissue Antigens 3: 439-453, 1973.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4130127/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4130127</a>] [<a href="https://doi.org/10.1111/j.1399-0039.1973.tb00514.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4130127">Solheim et al. (1973)</a> presented evidence for a third segregant HLA series, the 'AJ' series. AJ appears to be between LA and 'FOUR' but closer to 'FOUR.' <a href="#121" class="mim-tip-reference" title="Weitkamp, L. R., Van Rood, J. J., Thorsby, E., Bias, W. B., Fotino, M., Lawler, S. D., Dausset, J., Mayr, W. R., Bodmer, J., Ward, F. S., Seignalet, J., Payne, R., Kissmeyer-Nielsen, F., Gatti, R. A., Sachs, J. A., Lamm, L. U. <strong>The relation of parental sex and age to recombination in the HL-A system.</strong> Hum. Hered. 23: 197-205, 1973.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4760577/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4760577</a>] [<a href="https://doi.org/10.1159/000152574" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="4760577">Weitkamp et al. (1973)</a> showed that recombination between the LA and 'FOUR' loci was 50% greater in females than in males but age had no effect. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=4130127+4110124+4668408+4117674+4760577+5281183" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>From the study of the primary structure of cross-reactive human histocompatibility antigens, <a href="#74" class="mim-tip-reference" title="Lopez de Castro, J. A., Strominger, J. L., Strong, D. M., Orr, H. T. <strong>Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.</strong> Proc. Nat. Acad. Sci. 79: 3813-3817, 1982.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6179086/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6179086</a>] [<a href="https://doi.org/10.1073/pnas.79.12.3813" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="6179086">Lopez de Castro et al. (1982)</a> concluded that gene conversion may have played a role in the generation of HLA polymorphism. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6179086" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Extended haplotypes in the MHC are evidenced by allelic association, better known as linkage disequilibrium, which is usually attributed to recent mutation of closely linked genes, founder effects, inbreeding, and so on. Due to crossover events, such effects are rapidly dissipated at chromosome map distances of 2 to 7 cM. The operation of crossover suppression was suggested by the findings of extended haplotypes that take in A1, at one end, and the GLO2 allele at the GLO1 locus, at the other end, and occur at frequencies significantly higher than expected (<a href="#6" class="mim-tip-reference" title="Awdeh, Z. L., Raum, D., Yunis, E. J., Alper, C. A. <strong>Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man.</strong> Proc. Nat. Acad. Sci. 80: 259-263, 1983.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6401863/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6401863</a>] [<a href="https://doi.org/10.1073/pnas.80.1.259" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="6401863">Awdeh et al., 1983</a>). One of the haplotypes was found to be transmitted from males to 83% of their offspring. A possible mechanism for the maintenance of extended haplotypes is represented by possible human analogs of murine T mutants which are characterized by crossover suppression and male transmission bias. (According to <a href="#115" class="mim-tip-reference" title="Van Rood, J. J., Amos, D. B. <strong>In memoriam: Ruggero Ceppellini, 1917-1988.</strong> Hum. Immun. 23: 1-3, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3056890/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3056890</a>] [<a href="https://doi.org/10.1016/0198-8859(88)90012-2" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3056890">Van Rood and Amos (1988)</a>, Ruggero Ceppellini introduced the term haplotype.) <a href="#35" class="mim-tip-reference" title="Dausset, J. <strong>Personal Communication.</strong> Paris, France 1/12/1983."None>Dausset (1983)</a> stated that he had probes that correlate with specific HLA haplotypes, e.g., the following Weissmann probes: EcoRV 8.6 kb with HLA-B8; EcoRV 4.6 kb with HLA-B35. He suggested the term genotope for a DNA fragment and the derivative terms allogenotope for a DNA fragment with polymorphism and isogenotope for one without polymorphism. Of course, polymorphism is probably usually present, even though not demonstrated with the restriction enzymes employed. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=3056890+6401863" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<strong>ALLELIC VARIANTS (<a href="/help/faq#1_4"></strong>
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<a href="https://www.ncbi.nlm.nih.gov/clinvar?term=142800[MIM]" class="btn btn-default mim-tip-hint" role="button" title="ClinVar aggregates information about sequence variation and its relationship to human health." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ClinVar', 'domain': 'ncbi.nlm.nih.gov'})">ClinVar</a>
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<strong>.0001 HYPERSENSITIVITY SYNDROME, CARBAMAZEPINE-INDUCED, SUSCEPTIBILITY TO</strong>
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<div class="btn-group"> <button type="button" class="btn btn-default btn-xs dropdown-toggle mim-font" data-toggle="dropdown"><span class="text-primary">●</span> rs1061235 <span class="caret"></span></button> <ul class="dropdown-menu"> <li><a href="https://www.ensembl.org/Homo_sapiens/Variation/Summary?v=rs1061235;toggle_HGVS_names=open" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'dbSNP', 'domain': 'ensembl.org'})">Ensembl</a></li> <li><a href="https://gnomad.broadinstitute.org/variant/rs1061235?dataset=gnomad_r2_1" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'dbSNP', 'domain': 'gnomad.broadinstitute.org'})" style="padding-left: 8px;"><span class="text-primary">●</span> gnomAD</a></li> <li><a href="https://www.ncbi.nlm.nih.gov/snp/?term=rs1061235" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'dbSNP', 'domain': 'www.ncbi.nlm.nih.gov'})">NCBI</a></li> <li><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&clinvar=pack&omimAvSnp=pack&position=rs1061235" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'dbSNP', 'domain': 'genome.ucsc.edu'})">UCSC</a></li> </ul> </div>
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<p><a href="#81" class="mim-tip-reference" title="McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., Sills, G. J., Marson, T., Jia, X., de Bakker, P. I. W., Chinthapalli, K., Molokhia, M., and 18 others. <strong>HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.</strong> New Eng. J. Med. 364: 1134-1143, 2011.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/21428769/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">21428769</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=21428769[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1056/NEJMoa1013297" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="21428769">McCormack et al. (2011)</a> performed a genomewide association study of samples obtained from 22 subjects with carbamazepine (CBZ)-induced hypersensitivity syndrome (HSS; see <a href="/entry/608579">608579</a>), 43 subjects with CBZ-induced maculopapular exanthema (MPE), and 3,987 control subjects, all of European descent. They replicated the associations in samples from 145 subjects with CBZ-induced hypersensitivity reactions. The HLA-A*3101 allele, which has a prevalence of 2 to 5% in northern European populations, was significantly associated with HSS (p = 3.5 x 10(-8)). An independent genomewide association study of samples from subjects with MPE also showed an association with the HLA-A*3101 allele (p = 1.1 x 10(-6)). Follow-up genotyping confirmed the variant as a risk factor for HSS (OR, 12.41; 95 CI, 1.27-121.03), MPE (OR, 8.33; 95% CI, 3.59-19.36), and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS-TEN) (OR, 25.93; 95% CI, 4.93-116.18). The presence of the HLA-A*3101 allele was associated with CBZ-induced hypersensitivity reactions among subjects of northern European ancestry. The presence of the allele increased the risk from 5.0% to 26.0%, whereas its absence reduced the risk from 5.0% to 3.8%. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=21428769" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Among 18 Chinese patients, <a href="#55" class="mim-tip-reference" title="Hung, S.-I., Chung, W.-H., Jee, S.-H., Chen, W.-C., Chang, Y.-T., Lee, W.-R., Hu, S.-L., Wu, M.-T., Chen, G.-S., Wong, T.-W., Hsiao, P.-F., Chen, W.-H., Shih, H.-Y., Fang, W.-H., Wei, C.-Y., Lou, Y.-H., Huang, Y.-L., Lin, J.-J., Chen, Y.-T. <strong>Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.</strong> Pharmacogenet. Genomics 16: 297-306, 2006.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/16538176/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">16538176</a>] [<a href="https://doi.org/10.1097/01.fpc.0000199500.46842.4a" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="16538176">Hung et al. (2006)</a> found a significant association between nonbullous adverse skin reactions induced by the drug carbamazepine and the HLA-A*3101 allele (p = 2.2 x 10(-3), OR of 17.5). The association was specific for maculopapular eruptions and not SJS (see <a href="/entry/608579">608579</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=16538176" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p>Among 42 Canadian children of diverse ancestries who experienced carbamazepine (CBZ)-induced hypersensitivity reactions and 91 CBZ-tolerant control children, <a href="#3" class="mim-tip-reference" title="Amstutz, U., Ross, C. J. D., Castro-Pastrana, L. I., Rieder, M. J., Shear, N. H., Hayden, M. R., Carleton, B. C., the CPNDS Consortium. <strong>HLA-A*31:01 and HLA-B*15:02 as genetic markers for carbamazepine hypersensitivity in children.</strong> Clin. Pharm. Ther. 94: 142-149, 2013.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/23588310/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">23588310</a>] [<a href="https://doi.org/10.1038/clpt.2013.55" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="23588310">Amstutz et al. (2013)</a> found that HLA-A*3101 was significantly associated with CBZ-HSS (OR, 26.4; p = 0.0025) and MPE (OR, 8.6; p = 0.0037) but not with CBZ-SJS. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=23588310" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<span class="mim-font">
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<span id="mimSeeAlsoToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<strong>See Also:</strong>
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<a href="#Adman1970" class="mim-tip-reference" title="Adman, R., Pious, D. A. <strong>Isoantigenic variants: isolation from human diploid cells in culture.</strong> Science 168: 370-372, 1970.">Adman and Pious (1970)</a>; <a href="#Arnaiz-Villena1976" class="mim-tip-reference" title="Arnaiz-Villena, A., Festenstein, H. <strong>HLA genotyping by using spermatozoa: evidence for haploid gene expression.</strong> Lancet 308: 707-709, 1976. Note: Originally Volume II.">Arnaiz-Villena and Festenstein (1976)</a>; <a href="#Auffray1986" class="mim-tip-reference" title="Auffray, C., Strominger, J. L. <strong>Molecular genetics of the human major histocompatibility complex.</strong> Adv. Hum. Genet. 15: 197-247, 1986.">Auffray and Strominger (1986)</a>; <a href="#Bailey1971" class="mim-tip-reference" title="Bailey, D. W. <strong>Recombinant inbred strains: an aid to finding identity, linkage, and function of histocompatibility and other genes.</strong> Transplantation 1 1: 325-327, 1971.">Bailey (1971)</a>; <a href="#Balner1981" class="mim-tip-reference" title="Balner, H. <strong>The major histocompatibility complex of primates: evolutionary aspects and comparative histogenetics.</strong> Phil. Trans. Roy. Soc. London B Biol. Sci. 292: 109-119, 1981.">Balner (1981)</a>; <a href="#Bodmer1972" class="mim-tip-reference" title="Bodmer, W. F. (ed.). <strong>Evolutionary significance of the HL-A system.</strong> Nature 237: 139-145, 1972.">Bodmer
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(1972)</a>; <a href="#Bodmer1966" class="mim-tip-reference" title="Bodmer, W. F., Bodmer, J. G., Adler, S., Payne, R., Bialek, J. <strong>Genetics of '4' and 'LA' human leukocyte groups.</strong> Ann. N.Y. Acad. Sci. 129: 473-489, 1966.">Bodmer et al. (1966)</a>; <a href="#Bodmer1978" class="mim-tip-reference" title="Bodmer, W. F. <strong>The HLA System (17 papers).</strong> Brit. Med. Bull. 34: 213-316, 1978.">Bodmer (1978)</a>; <a href="#Breuning1977" class="mim-tip-reference" title="Breuning, M. H., van den Berg-Loonen, E. M., Bernini, L. F., Bijlsma, J. B., van Loghem, E., Meera Khan, P., Nijenhuis, L. E. <strong>Localization of HLA on the short arm of chromosome 6.</strong> Hum. Genet. 37: 131-139, 1977.">Breuning et al. (1977)</a>; <a href="#Bull1978" class="mim-tip-reference" title="Bull, R. W., Benson, J. W., Pearson, G., Mann, J. D. <strong>HLA substantiation of a trisomic human chromosome 6.</strong> Transplant. Proc. 10: 747-748, 1978.">Bull et al. (1978)</a>; <a href="#Ceppellini1974" class="mim-tip-reference" title="Ceppellini, R., Van Rood, J. J. <strong>The HL-A system. I. Genetics and molecular biology.</strong> Semin. Hemat. 11: 233-252, 1974.">Ceppellini and Van Rood (1974)</a>; <a href="#Cohen1983" class="mim-tip-reference" title="Cohen, D., Paul, P., Font, M.-P., Cohen, O., Sayagh, B., Marcadet, A., Busson, M., Mahouy, G., Cann, H. M., Dausset, J. <strong>Analysis of HLA class I genes with restriction endonuclease fragments: implications for polymorphism of the human major histocompatibility complex.</strong> Proc. Nat. Acad. Sci. 80: 6289-6292, 1983.">Cohen et al.
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(1983)</a>; <a href="#Dausset1967" class="mim-tip-reference" title="Dausset, J., Ivanyi, P., Colombani, J., Feingold, N., Legrand, L. <strong>Le systeme Hu-1: etudes genetiques de population et de familles.</strong> Nouv. Rev. Franc. Hemat. 7: 897-899, 1967.">Dausset et al. (1967)</a>; <a href="#Dausset1972" class="mim-tip-reference" title="Dausset, J. <strong>Similarities between the HL-A system and other immunogenetic systems. (Editorial)</strong> Vox Sang. 23: 153-164, 1972.">Dausset (1972)</a>; <a href="#Dausset1981" class="mim-tip-reference" title="Dausset, J. <strong>The major histocompatibility complex in man: past, present, and future concepts.</strong> Science 213: 1469-1474, 1981.">Dausset (1981)</a>; <a href="#Edwards1973" class="mim-tip-reference" title="Edwards, J. H., Allen, F. H., Glenn, K. P., Lamm, L. U., Robson, E. B. <strong>The linkage relationships of HL-A. In: Histocompatibility Testing.</strong> Baltimore: Williams and Wilkins 1973.">Edwards et al. (1973)</a>; <a href="#Engelfriet1965" class="mim-tip-reference" title="Engelfriet, C. P., Britten, A. <strong>The cytotoxic test for leucocyte antibodies. A simple and reliable technique.</strong> Vox Sang. 10: 660-674, 1965.">Engelfriet and Britten (1965)</a>; <a href="#Erlich1983" class="mim-tip-reference" title="Erlich, H. A., Stetler, D., Sheng-Dong, R., Ness, D., Grumet, C. <strong>Segregation and mapping analysis of polymorphic HLA class I restriction fragments: detection of a novel fragment.</strong> Science 222: 72-74, 1983.">Erlich et al.
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(1983)</a>; <a href="#Fellous1970" class="mim-tip-reference" title="Fellous, M., Dausset, J. <strong>Probable haploid expression of HL-A antigens on human spermatozoon.</strong> Nature 225: 191-193, 1970.">Fellous and Dausset (1970)</a>; <a href="#Francke1977" class="mim-tip-reference" title="Francke, U., Pellegrino, M. A. <strong>Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.</strong> Proc. Nat. Acad. Sci. 74: 1147-1151, 1977.">Francke and Pellegrino (1977)</a>; <a href="#Gill1978" class="mim-tip-reference" title="Gill, T. J., III, Cramer, D. V., Kunz, H. W. <strong>The major histocompatibility complex--comparison in the mouse, man, and the rat: a review.</strong> Am. J. Path. 90: 735-777, 1978.">Gill et al. (1978)</a>; <a href="#Gladstone1982" class="mim-tip-reference" title="Gladstone, P., Fueresz, L., Pious, D. <strong>Gene dosage and gene expression in the HLA region: evidence from deletion variants.</strong> Proc. Nat. Acad. Sci. 79: 1235-1239, 1982.">Gladstone et al. (1982)</a>; <a href="#Goodfellow1975" class="mim-tip-reference" title="Goodfellow, P. N., Jones, E., Van Heyningen, V., Solomon, E., Kennett, R., Bobrow, M., Bodmer, W. F. <strong>Linkage relationships of the HL-A system and beta-2-microglobulin.</strong> Birth Defects Orig. Art. Ser. 11(3): 162-167, 1975. Note: Alternate: Cytogenet. Cell Genet. 14: 332-337, 1975.">Goodfellow et al.
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(1975)</a>; <a href="#Helenius1978" class="mim-tip-reference" title="Helenius, A., Morein, B., Fries, E., Simons, K., Robinson, P., Schirrmacher, V., Terhorst, C., Strominger, J. L. <strong>Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus.</strong> Proc. Nat. Acad. Sci. 75: 3846-3850, 1978.">Helenius et al. (1978)</a>; <a href="#Jordan1981" class="mim-tip-reference" title="Jordan, B. R., Bregegere, F., Kourilsky, P. <strong>Human HLA gene segment isolated by hybridization with mouse H-2 cDNA probes.</strong> Nature 290: 521-523, 1981.">Jordan et al. (1981)</a>; <a href="#Kissmeyer-Nielsen1969" class="mim-tip-reference" title="Kissmeyer-Nielsen, F., Svejgaard, A., Ahrons, S., Nielsen, L. S. <strong>Crossing-over within the HL-A system.</strong> Nature 224: 75-76, 1969.">Kissmeyer-Nielsen et al. (1969)</a>; <a href="#Kissmeyer-Nielsen1968" class="mim-tip-reference" title="Kissmeyer-Nielsen, F., Svejgaard, A., Hauge, M. <strong>Genetics of the human HL-A transplantation system.</strong> Nature 219: 1116-1119, 1968.">Kissmeyer-Nielsen et al. (1968)</a>; <a href="#Lamm1975" class="mim-tip-reference" title="Lamm, L. U., Thorsen, I.-L., Petersen, G. B., Jorgensen, J., Henningsen, K., Bech, B., Kissmeyer-Nielsen, F. <strong>Data on the HL-A linkage group.</strong> Ann. Hum. Genet. 38: 383-390, 1975.">Lamm et al. (1975)</a>; <a href="#Levine1985" class="mim-tip-reference" title="Levine, F., Erlich, H., Mach, B., Leach, R., White, R., Pious, D. <strong>Deletion mapping of HLA and chromosome 6p genes.</strong> Proc. Nat. Acad. Sci. 82: 3741-3745, 1985.">Levine et al. (1985)</a>; <a href="#Mayr1974" class="mim-tip-reference" title="Mayr, W. R., Mayr, D. <strong>Analysis of the linkage between the HL-A loci and the genes of other markers.</strong> Humangenetik 24: 129-133, 1974.">Mayr and Mayr (1974)</a>; <a href="#Orr1982" class="mim-tip-reference" title="Orr, H. T., Bach, F. H., Ploegh, H. L., Strominger, J. L., Kavathas, P., DeMars, R. <strong>Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex.</strong> Nature 296: 454-456, 1982.">Orr
|
|
et al. (1982)</a>; <a href="#Payne1964" class="mim-tip-reference" title="Payne, R., Tripp, M., Weigle, J., Bodmer, W. F., Bodmer, J. G. <strong>A new leukocyte isoantigen system in man.</strong> Cold Spring Harbor Symp. Quant. Biol. 29: 285-295, 1964.">Payne et al. (1964)</a>; <a href="#Snell1981" class="mim-tip-reference" title="Snell, G. D. <strong>Studies in histocompatibility.</strong> Science 213: 172-178, 1981.">Snell (1981)</a>; <a href="#Thorsby1970" class="mim-tip-reference" title="Thorsby, E., Sandberg, L., Lindholm, A., Kissmeyer-Nielsen, F. <strong>The HL-A system: evidence of a third sub-locus.</strong> Scand. J. Haemat. 7: 195-200, 1970.">Thorsby et al.
|
|
(1970)</a>; <a href="#Tiwari1985" class="mim-tip-reference" title="Tiwari, J. L., Terasaki, P. I. <strong>HLA and Disease Associations.</strong> New York: Springer-Verlag (pub.) 1985.">Tiwari and Terasaki (1985)</a>; <a href="#Uhr1979" class="mim-tip-reference" title="Uhr, J. W., Capra, J. D., Vitetta, E. S., Cook, R. G. <strong>Organization of the immune response genes.</strong> Science 206: 292-297, 1979.">Uhr et al. (1979)</a>; <a href="#Van1964" class="mim-tip-reference" title="Van Leeuwen, A., Eernisse, J. G., Van Rood, J. J. <strong>A new leucocyte group with two alleles: leucocyte group five.</strong> Vox Sang. 9: 431-446, 1964.">Van Leeuwen et
|
|
al. (1964)</a>; <a href="#Van1963" class="mim-tip-reference" title="Van Rood, J. J., Van Leeuwen, A. <strong>Leukocyte grouping: a method and its application.</strong> J. Clin. Invest. 42: 1382-1390, 1963.">Van Rood and Van Leeuwen (1963)</a>; <a href="#Van1969" class="mim-tip-reference" title="Van Rood, J. J. <strong>Tissue typing and organ transplantation.</strong> Lancet 293: 1142-1146, 1969. Note: Originally Volume I.">Van Rood (1969)</a>; <a href="#Van1969" class="mim-tip-reference" title="Van Rood, J. J. <strong>Tissue typing and organ transplantation.</strong> Lancet 293: 1142-1146, 1969. Note: Originally Volume I.">Van
|
|
Rood (1969)</a>; <a href="#Van1974" class="mim-tip-reference" title="Van Someren, H., Westerveld, A., Hagemeijer, A., Mees, J. R., Meera Khan, P., Zaalberg, O. B. <strong>Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: evidence for synteny between the HL-A, PGM-3, ME-1, and IPO-B loci.</strong> Proc. Nat. Acad. Sci. 71: 962-965, 1974.">Van Someren et al. (1974)</a>; <a href="#Walford1969" class="mim-tip-reference" title="Walford, R. L., Finkelstein, S., Hanna, C., Collins, Z. <strong>Third sublocus in the HL-A human transplantation system.</strong> Nature 224: 74-75, 1969.">Walford et al. (1969)</a>; <a href="#Wolski1975" class="mim-tip-reference" title="Wolski, K. P., Schmid, F. R., Mittal, K. K. <strong>Genetic linkage between the HL-A system and a deficit of the second component (C2) of complement.</strong> Science 188: 1020-1022, 1975.">Wolski
|
|
et al. (1975)</a>
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
</div>
|
|
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|
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|
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<h4 href="#mimReferencesFold" id="mimReferencesToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
|
|
<span class="mim-font">
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<span id="mimReferencesToggleTriangle" class="small mimTextToggleTriangle">▼</span>
|
|
<strong>REFERENCES</strong>
|
|
</span>
|
|
</h4>
|
|
<div>
|
|
<p />
|
|
</div>
|
|
|
|
<div id="mimReferencesFold" class="collapse in mimTextToggleFold">
|
|
<ol>
|
|
|
|
<li>
|
|
<a id="1" class="mim-anchor"></a>
|
|
<a id="Abderrahim1994" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Abderrahim, H., Sambucy, J.-L., Iris, F., Ougen, P., Billault, A., Chumakov, I. M., Dausset, J., Cohen, D., Le Paslier, D.
|
|
<strong>Cloning the human major histocompatibility complex in YACs.</strong>
|
|
Genomics 23: 520-527, 1994.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7851878/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7851878</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7851878" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1006/geno.1994.1538" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="2" class="mim-anchor"></a>
|
|
<a id="Adman1970" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Adman, R., Pious, D. A.
|
|
<strong>Isoantigenic variants: isolation from human diploid cells in culture.</strong>
|
|
Science 168: 370-372, 1970.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5461672/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5461672</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5461672" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.168.3929.370" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="3" class="mim-anchor"></a>
|
|
<a id="Amstutz2013" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Amstutz, U., Ross, C. J. D., Castro-Pastrana, L. I., Rieder, M. J., Shear, N. H., Hayden, M. R., Carleton, B. C., the CPNDS Consortium.
|
|
<strong>HLA-A*31:01 and HLA-B*15:02 as genetic markers for carbamazepine hypersensitivity in children.</strong>
|
|
Clin. Pharm. Ther. 94: 142-149, 2013.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/23588310/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">23588310</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=23588310" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/clpt.2013.55" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="4" class="mim-anchor"></a>
|
|
<a id="Arnaiz-Villena1976" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Arnaiz-Villena, A., Festenstein, H.
|
|
<strong>HLA genotyping by using spermatozoa: evidence for haploid gene expression.</strong>
|
|
Lancet 308: 707-709, 1976. Note: Originally Volume II.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/61393/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">61393</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=61393" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/s0140-6736(76)90005-2" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="5" class="mim-anchor"></a>
|
|
<a id="Auffray1986" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Auffray, C., Strominger, J. L.
|
|
<strong>Molecular genetics of the human major histocompatibility complex.</strong>
|
|
Adv. Hum. Genet. 15: 197-247, 1986.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3513484/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3513484</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3513484" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1007/978-1-4615-8356-1_4" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="6" class="mim-anchor"></a>
|
|
<a id="Awdeh1983" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Awdeh, Z. L., Raum, D., Yunis, E. J., Alper, C. A.
|
|
<strong>Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man.</strong>
|
|
Proc. Nat. Acad. Sci. 80: 259-263, 1983.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6401863/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6401863</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6401863" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.80.1.259" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="7" class="mim-anchor"></a>
|
|
<a id="Bach1967" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bach, F. H., Amos, D. B.
|
|
<strong>Hu-1 major histocompatibility locus in man.</strong>
|
|
Science 156: 1506-1508, 1967.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4887739/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4887739</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4887739" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.156.3781.1506" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="8" class="mim-anchor"></a>
|
|
<a id="Bach1970" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bach, M. L., Bach, F. H.
|
|
<strong>The genetics of histocompatibility.</strong>
|
|
Hosp. Practice 5(8): 33-44, 1970.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="9" class="mim-anchor"></a>
|
|
<a id="Bailey1971" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bailey, D. W.
|
|
<strong>Recombinant inbred strains: an aid to finding identity, linkage, and function of histocompatibility and other genes.</strong>
|
|
Transplantation 1 1: 325-327, 1971.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="10" class="mim-anchor"></a>
|
|
<a id="Bakker1979" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bakker, E., Pearson, P. L., Meera Khan, P., Schreuder, G. M. T., Madan, K.
|
|
<strong>Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6.</strong>
|
|
Clin. Genet. 15: 198-202, 1979.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/761421/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">761421</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=761421" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1399-0004.1979.tb01762.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="11" class="mim-anchor"></a>
|
|
<a id="Balner1974" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Balner, H., D'Amaro, J., Visser, T. P.
|
|
<strong>Tissue typing of chimpanzees: I. Evidence for two allelic series of leukocyte antigens.</strong>
|
|
Transplant. Proc. 6: 141-149, 1974.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4831531/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4831531</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4831531" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="12" class="mim-anchor"></a>
|
|
<a id="Balner1981" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Balner, H.
|
|
<strong>The major histocompatibility complex of primates: evolutionary aspects and comparative histogenetics.</strong>
|
|
Phil. Trans. Roy. Soc. London B Biol. Sci. 292: 109-119, 1981.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6115401/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6115401</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6115401" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1098/rstb.1981.0019" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="13" class="mim-anchor"></a>
|
|
<a id="Berger1979" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Berger, R., Bernheim, A., Sasportes, M., Hauptmann, G., Hors, J., Legrand, L., Fellous, M.
|
|
<strong>Regional mapping of the HLA on the short arm of chromosome 6.</strong>
|
|
Clin. Genet. 15: 245-251, 1979.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/84721/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">84721</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=84721" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1399-0004.1979.tb00975.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="14" class="mim-anchor"></a>
|
|
<a id="Bernard1967" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bernard, J.
|
|
<strong>La decouverte du systeme principal d'histocompatibilite de l'homme. (Editorial)</strong>
|
|
Presse Med. 75: 2369 only, 1967.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6060307/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6060307</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6060307" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="15" class="mim-anchor"></a>
|
|
<a id="Bodmer1972" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F. (ed.).
|
|
<strong>Evolutionary significance of the HL-A system.</strong>
|
|
Nature 237: 139-145, 1972.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4113158/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4113158</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4113158" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/237139a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="16" class="mim-anchor"></a>
|
|
<a id="Bodmer1966" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F., Bodmer, J. G., Adler, S., Payne, R., Bialek, J.
|
|
<strong>Genetics of '4' and 'LA' human leukocyte groups.</strong>
|
|
Ann. N.Y. Acad. Sci. 129: 473-489, 1966.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="17" class="mim-anchor"></a>
|
|
<a id="Bodmer1970" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F., Bodmer, J. G., Tripp, M.
|
|
<strong>Recombination between the LA and 4 loci of the HL-A system. In: Histocompatibility Testing 1970.</strong>
|
|
Copenhagen: Munksgaard 1970. Pp. 187-191.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="18" class="mim-anchor"></a>
|
|
<a id="Bodmer1978" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F.
|
|
<strong>The HLA System (17 papers).</strong>
|
|
Brit. Med. Bull. 34: 213-316, 1978.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/719335/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">719335</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=719335" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1093/oxfordjournals.bmb.a071500" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="19" class="mim-anchor"></a>
|
|
<a id="Bodmer1986" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F.
|
|
<strong>Personal Communication.</strong>
|
|
London, England 9/26/1986.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="20" class="mim-anchor"></a>
|
|
<a id="Borgaonkar1973" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Borgaonkar, D. S., Bias, W. B., Chase, G. A., Sadasivan, G., Herr, H. M., Golomb, H. M., Bahr, G. F., Kunkel, L. M.
|
|
<strong>Identification of C6-G21 translocation chromosome by the Q-M and Giemsa banding techniques in a patient with Down's syndrome, with possible assignment of Gm locus.</strong>
|
|
Clin. Genet. 4: 53-57, 1973.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4120631/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4120631</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4120631" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1399-0004.1973.tb01122.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="21" class="mim-anchor"></a>
|
|
<a id="Borgaonkar1974" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Borgaonkar, D. S., Bias, W. B.
|
|
<strong>HL-A loci and chromosome 6.</strong>
|
|
Birth Defects Orig. Art. Ser. X(3): 67-68, 1974.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="22" class="mim-anchor"></a>
|
|
<a id="Breuning1977" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Breuning, M. H., van den Berg-Loonen, E. M., Bernini, L. F., Bijlsma, J. B., van Loghem, E., Meera Khan, P., Nijenhuis, L. E.
|
|
<strong>Localization of HLA on the short arm of chromosome 6.</strong>
|
|
Hum. Genet. 37: 131-139, 1977.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/885534/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">885534</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=885534" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1007/BF00393575" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="23" class="mim-anchor"></a>
|
|
<a id="Bull1978" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Bull, R. W., Benson, J. W., Pearson, G., Mann, J. D.
|
|
<strong>HLA substantiation of a trisomic human chromosome 6.</strong>
|
|
Transplant. Proc. 10: 747-748, 1978.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/734744/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">734744</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=734744" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="24" class="mim-anchor"></a>
|
|
<a id="Cadwell2005" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Cadwell, K., Coscoy, L.
|
|
<strong>Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.</strong>
|
|
Science 309: 127-130, 2005. Note: Erratum: Science 311: 177 only, 2006.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15994556/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15994556</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15994556" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.1110340" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="25" class="mim-anchor"></a>
|
|
<a id="Campbell1993" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Campbell, R. D., Trowsdale, J.
|
|
<strong>Map of the human MHC.</strong>
|
|
Immun. Today 14: 349-352, 1993.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8363724/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8363724</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8363724" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0167-5699(93)90234-C" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="26" class="mim-anchor"></a>
|
|
<a id="Cardoso2002" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Cardoso, C. S., Alves, H., Mascarenhas, M., Goncalves, R., Oliveira, P., Rodrigues, P., Cruz, E., de Sousa, M., Porto, G.
|
|
<strong>Co-selection of the H63D mutation and the HLA-A29 allele: a new paradigm of linkage disequilibrium?</strong>
|
|
Immunogenetics 53: 1002-1008, 2002.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11904676/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11904676</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11904676" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1007/s00251-001-0414-8" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="27" class="mim-anchor"></a>
|
|
<a id="Carrington1999" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., O'Brien, S. J.
|
|
<strong>HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.</strong>
|
|
Science 283: 1748-1752, 1999.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10073943/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10073943</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10073943" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.283.5408.1748" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="28" class="mim-anchor"></a>
|
|
<a id="Ceppellini1974" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Ceppellini, R., Van Rood, J. J.
|
|
<strong>The HL-A system. I. Genetics and molecular biology.</strong>
|
|
Semin. Hemat. 11: 233-252, 1974.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4151844/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4151844</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4151844" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="29" class="mim-anchor"></a>
|
|
<a id="Cohen1983" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Cohen, D., Paul, P., Font, M.-P., Cohen, O., Sayagh, B., Marcadet, A., Busson, M., Mahouy, G., Cann, H. M., Dausset, J.
|
|
<strong>Analysis of HLA class I genes with restriction endonuclease fragments: implications for polymorphism of the human major histocompatibility complex.</strong>
|
|
Proc. Nat. Acad. Sci. 80: 6289-6292, 1983.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6312451/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6312451</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6312451" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.80.20.6289" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="30" class="mim-anchor"></a>
|
|
<a id="Colombani1992" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Colombani, J.
|
|
<strong>Changing the name of the major histocompatibility complex.</strong>
|
|
Res. Immun. 143: 411-417, 1992.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1518955/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1518955</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1518955" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/s0923-2494(05)80073-2" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="31" class="mim-anchor"></a>
|
|
<a id="Danchin2003" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Danchin, E. G. J., Abi-Rached, L., Gilles, A., Pontarotti, P.
|
|
<strong>Conservation of the MHC-like region throughout evolution.</strong>
|
|
Immunogenetics 55: 141-148, 2003.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12734695/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12734695</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12734695" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1007/s00251-003-0562-0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="32" class="mim-anchor"></a>
|
|
<a id="Dausset1967" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Dausset, J., Ivanyi, P., Colombani, J., Feingold, N., Legrand, L.
|
|
<strong>Le systeme Hu-1: etudes genetiques de population et de familles.</strong>
|
|
Nouv. Rev. Franc. Hemat. 7: 897-899, 1967.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4230384/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4230384</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4230384" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="33" class="mim-anchor"></a>
|
|
<a id="Dausset1972" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Dausset, J.
|
|
<strong>Similarities between the HL-A system and other immunogenetic systems. (Editorial)</strong>
|
|
Vox Sang. 23: 153-164, 1972.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4116477/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4116477</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4116477" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1423-0410.1972.tb03997.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="34" class="mim-anchor"></a>
|
|
<a id="Dausset1981" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Dausset, J.
|
|
<strong>The major histocompatibility complex in man: past, present, and future concepts.</strong>
|
|
Science 213: 1469-1474, 1981.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6792704/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6792704</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6792704" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.6792704" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="35" class="mim-anchor"></a>
|
|
<a id="Dausset1983" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Dausset, J.
|
|
<strong>Personal Communication.</strong>
|
|
Paris, France 1/12/1983.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="36" class="mim-anchor"></a>
|
|
<a id="de Groot2002" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
de Groot, N. G., Otting, N., Doxiadis, G. G. M., Balla-Jhagjhoorsingh, S. S., Heeney, J. L., van Rood, J. J., Gagneux, P., Bontrop, R. E.
|
|
<strong>Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees.</strong>
|
|
Proc. Nat. Acad. Sci. 99: 11748-11753, 2002.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12186979/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12186979</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=12186979[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12186979" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.182420799" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="37" class="mim-anchor"></a>
|
|
<a id="Dorf1974" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Dorf, M. E., Balner, H., DeGroot, M. L., Benacerraf, B.
|
|
<strong>Histocompatibility-linked immune-response genes in the Rhesus monkey.</strong>
|
|
Transplant. Proc. 6: 119-124, 1974.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4208749/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4208749</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4208749" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="38" class="mim-anchor"></a>
|
|
<a id="Edwards1973" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Edwards, J. H., Allen, F. H., Glenn, K. P., Lamm, L. U., Robson, E. B.
|
|
<strong>The linkage relationships of HL-A. In: Histocompatibility Testing.</strong>
|
|
Baltimore: Williams and Wilkins 1973.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="39" class="mim-anchor"></a>
|
|
<a id="Engelfriet1965" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Engelfriet, C. P., Britten, A.
|
|
<strong>The cytotoxic test for leucocyte antibodies. A simple and reliable technique.</strong>
|
|
Vox Sang. 10: 660-674, 1965.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4955436/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4955436</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4955436" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1423-0410.1965.tb05178.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="40" class="mim-anchor"></a>
|
|
<a id="Erlich1983" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Erlich, H. A., Stetler, D., Sheng-Dong, R., Ness, D., Grumet, C.
|
|
<strong>Segregation and mapping analysis of polymorphic HLA class I restriction fragments: detection of a novel fragment.</strong>
|
|
Science 222: 72-74, 1983.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6312559/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6312559</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6312559" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.6312559" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="41" class="mim-anchor"></a>
|
|
<a id="Fellous1970" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Fellous, M., Dausset, J.
|
|
<strong>Probable haploid expression of HL-A antigens on human spermatozoon.</strong>
|
|
Nature 225: 191-193, 1970.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5409969/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5409969</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5409969" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/225191a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="42" class="mim-anchor"></a>
|
|
<a id="Figueroa1988" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Figueroa, F., Gunther, E., Klein, J.
|
|
<strong>MHC polymorphism pre-dating speciation. (Letter)</strong>
|
|
Nature 335: 265-267, 1988.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3137477/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3137477</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3137477" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/335265a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="43" class="mim-anchor"></a>
|
|
<a id="Francke1977" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Francke, U., Pellegrino, M. A.
|
|
<strong>Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.</strong>
|
|
Proc. Nat. Acad. Sci. 74: 5776 only, 1977.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="44" class="mim-anchor"></a>
|
|
<a id="Francke1977" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Francke, U., Pellegrino, M. A.
|
|
<strong>Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.</strong>
|
|
Proc. Nat. Acad. Sci. 74: 1147-1151, 1977.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/265561/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">265561</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=265561" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.74.3.1147" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="45" class="mim-anchor"></a>
|
|
<a id="Gill1978" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Gill, T. J., III, Cramer, D. V., Kunz, H. W.
|
|
<strong>The major histocompatibility complex--comparison in the mouse, man, and the rat: a review.</strong>
|
|
Am. J. Path. 90: 735-777, 1978.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/24344/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">24344</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=24344" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="46" class="mim-anchor"></a>
|
|
<a id="Gladstone1982" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Gladstone, P., Fueresz, L., Pious, D.
|
|
<strong>Gene dosage and gene expression in the HLA region: evidence from deletion variants.</strong>
|
|
Proc. Nat. Acad. Sci. 79: 1235-1239, 1982.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6951171/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6951171</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6951171" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.79.4.1235" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="47" class="mim-anchor"></a>
|
|
<a id="Gluecksohn-Waelsch1970" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Gluecksohn-Waelsch, S., Erickson, R. P.
|
|
<strong>The T-locus of the mouse: implications for mechanisms of development.</strong>
|
|
Curr. Top. Dev. Biol. 5: 281-316, 1970.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4120274/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4120274</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4120274" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/s0070-2153(08)60058-7" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="48" class="mim-anchor"></a>
|
|
<a id="Goodfellow1975" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Goodfellow, P. N., Jones, E., Van Heyningen, V., Solomon, E., Kennett, R., Bobrow, M., Bodmer, W. F.
|
|
<strong>Linkage relationships of the HL-A system and beta-2-microglobulin.</strong>
|
|
Birth Defects Orig. Art. Ser. 11(3): 162-167, 1975. Note: Alternate: Cytogenet. Cell Genet. 14: 332-337, 1975.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/54197/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">54197</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=54197" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="49" class="mim-anchor"></a>
|
|
<a id="Gruen1996" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Gruen, J. R., Nalabolu, S. R., Chu, T. W., Bowlus, C., Fan, W. F., Goei, V. L., Wei, H., Sivakamasundari, R., Liu, Y.-C., Xu, H. X., Parimoo, S., Nallur, G., Ajioka, R., Shukla, H., Bray-Ward, P., Pan, J., Weissman, S. M.
|
|
<strong>A transcription map of the major histocompatibility complex (MHC) class I region.</strong>
|
|
Genomics 36: 70-85, 1996.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8812418/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8812418</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8812418" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1006/geno.1996.0427" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="50" class="mim-anchor"></a>
|
|
<a id="Habegger de Sorrentino2013" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Habegger de Sorrentino, A., Sinchi, J. L., Marinic, K., Lopez, R., Iliovich, E.
|
|
<strong>KIR-HLA-A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina.</strong>
|
|
Immunology 140: 273-279, 2013.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/23789883/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">23789883</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=23789883" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/imm.12137" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="51" class="mim-anchor"></a>
|
|
<a id="Hedrick1992" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Hedrick, S. M.
|
|
<strong>Dawn of the hunt for nonclassical MHC function.</strong>
|
|
Cell 70: 177-180, 1992.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1322246/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1322246</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1322246" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0092-8674(92)90092-q" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="52" class="mim-anchor"></a>
|
|
<a id="Helenius1978" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Helenius, A., Morein, B., Fries, E., Simons, K., Robinson, P., Schirrmacher, V., Terhorst, C., Strominger, J. L.
|
|
<strong>Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus.</strong>
|
|
Proc. Nat. Acad. Sci. 75: 3846-3850, 1978.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/278998/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">278998</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=278998" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.75.8.3846" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="53" class="mim-anchor"></a>
|
|
<a id="Hirai1991" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Hirai, M., Takahashi, E., Ishida, T., Hori, T.
|
|
<strong>Chromosomal localization of the major histocompatibility complex (MHC) in the rhesus monkey and chimpanzee by fluorescence in situ hybridization.</strong>
|
|
Cytogenet. Cell Genet. 57: 204-205, 1991.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1743075/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1743075</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1743075" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1159/000133147" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="54" class="mim-anchor"></a>
|
|
<a id="Hood1982" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Hood, L., Steinmetz, M., Goodenow, R.
|
|
<strong>Genes of the major histocompatibility complex.</strong>
|
|
Cell 28: 685-687, 1982.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6284368/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6284368</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6284368" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0092-8674(82)90046-0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="55" class="mim-anchor"></a>
|
|
<a id="Hung2006" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Hung, S.-I., Chung, W.-H., Jee, S.-H., Chen, W.-C., Chang, Y.-T., Lee, W.-R., Hu, S.-L., Wu, M.-T., Chen, G.-S., Wong, T.-W., Hsiao, P.-F., Chen, W.-H., Shih, H.-Y., Fang, W.-H., Wei, C.-Y., Lou, Y.-H., Huang, Y.-L., Lin, J.-J., Chen, Y.-T.
|
|
<strong>Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.</strong>
|
|
Pharmacogenet. Genomics 16: 297-306, 2006.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/16538176/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">16538176</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=16538176" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1097/01.fpc.0000199500.46842.4a" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="56" class="mim-anchor"></a>
|
|
<a id="{International Multiple Sclerosis Genetics Consortium}2011" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2.
|
|
<strong>Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.</strong>
|
|
Nature 476: 214-219, 2011.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/21833088/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">21833088</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=21833088[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=21833088" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/nature10251" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="57" class="mim-anchor"></a>
|
|
<a id="Jordan1981" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Jordan, B. R., Bregegere, F., Kourilsky, P.
|
|
<strong>Human HLA gene segment isolated by hybridization with mouse H-2 cDNA probes.</strong>
|
|
Nature 290: 521-523, 1981.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6452579/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6452579</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6452579" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/290521a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="58" class="mim-anchor"></a>
|
|
<a id="Kissmeyer-Nielsen1972" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Jorgensen, F., Lamm, L. U.
|
|
<strong>The HL-A system in clinical medicine.</strong>
|
|
Johns Hopkins Med. J. 131: 385-400, 1972.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4117674/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4117674</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4117674" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="59" class="mim-anchor"></a>
|
|
<a id="Kissmeyer-Nielsen1969" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Svejgaard, A., Ahrons, S., Nielsen, L. S.
|
|
<strong>Crossing-over within the HL-A system.</strong>
|
|
Nature 224: 75-76, 1969.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5822911/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5822911</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5822911" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/224075a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="60" class="mim-anchor"></a>
|
|
<a id="Kissmeyer-Nielsen1968" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Svejgaard, A., Hauge, M.
|
|
<strong>Genetics of the human HL-A transplantation system.</strong>
|
|
Nature 219: 1116-1119, 1968.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5675623/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5675623</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5675623" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/2191116a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="61" class="mim-anchor"></a>
|
|
<a id="Kissmeyer-Nielsen1970" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Thorsby, E.
|
|
<strong>Human transplantation antigens.</strong>
|
|
Transplant. Rev. 4: 1-176, 1970.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4110124/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4110124</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4110124" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="62" class="mim-anchor"></a>
|
|
<a id="Klein1986" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Klein, J., Figueroa, F.
|
|
<strong>Evolution of the major histocompatibility complex.</strong>
|
|
CRC Crit. Rev. Immun. 6: 295-386, 1986.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3536303/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3536303</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3536303" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="63" class="mim-anchor"></a>
|
|
<a id="Klein1979" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Klein, J.
|
|
<strong>The major histocompatibility complex of the mouse.</strong>
|
|
Science 203: 516-521, 1979.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/104386/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">104386</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=104386" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.104386" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="64" class="mim-anchor"></a>
|
|
<a id="Kompf1978" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Kompf, J., Bissbort, S., Gohler, F., Schunter, F., Wernet, P.
|
|
<strong>Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM. I. Recombination frequencies.</strong>
|
|
Hum. Genet. 44: 313-319, 1978.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/730169/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">730169</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=730169" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1007/BF00394296" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="65" class="mim-anchor"></a>
|
|
<a id="Lamm1974" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Friedrich, U., Petersen, G. B., Jorgensen, J., Nielsen, J., Therkelsen, A. J., Kissmeyer-Nielsen, F.
|
|
<strong>Assignment of the major histocompatibility complex to chromosome no. 6 in a family with a pericentric inversion.</strong>
|
|
Hum. Hered. 24: 273-284, 1974.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4435793/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4435793</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4435793" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1159/000152660" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="66" class="mim-anchor"></a>
|
|
<a id="Lamm1972" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Kissmeyer-Nielsen, F., Svejgaard, A., Petersen, G. B., Thorsby, E., Mayr, W., Hogman, C.
|
|
<strong>On the orientation of the HL-A region and the PGM(3) locus in the chromosome.</strong>
|
|
Tissue Antigens 2: 205-214, 1972.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4668408/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4668408</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4668408" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1399-0039.1972.tb00137.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="67" class="mim-anchor"></a>
|
|
<a id="Lamm1971" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Svejgaard, A., Kissmeyer-Nielsen, F.
|
|
<strong>Further evidence for PGM(3): HL-A is another linkage in man.</strong>
|
|
Nature N.B. 231: 109-110, 1971.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5281183/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5281183</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5281183" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/newbio231109a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="68" class="mim-anchor"></a>
|
|
<a id="Lamm1975" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Thorsen, I.-L., Petersen, G. B., Jorgensen, J., Henningsen, K., Bech, B., Kissmeyer-Nielsen, F.
|
|
<strong>Data on the HL-A linkage group.</strong>
|
|
Ann. Hum. Genet. 38: 383-390, 1975.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1190732/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1190732</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1190732" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1469-1809.1975.tb00628.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="69" class="mim-anchor"></a>
|
|
<a id="Lawlor1991" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lawlor, D. A., Dickel, C. D., Hauswirth, W. W., Parham, P.
|
|
<strong>Ancient HLA genes from 7,500-year-old archaeological remains.</strong>
|
|
Nature 349: 785-788, 1991.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2000147/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2000147</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2000147" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/349785a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="70" class="mim-anchor"></a>
|
|
<a id="Lawlor1988" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lawlor, D. A., Ward, F. E., Ennis, P. D., Jackson, A. P., Parham, P.
|
|
<strong>HLA-A and B polymorphisms predate the divergence of humans and chimpanzees. (Letter)</strong>
|
|
Nature 335: 268-271, 1988.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3412487/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3412487</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3412487" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/335268a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="71" class="mim-anchor"></a>
|
|
<a id="Lawrance1987" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lawrance, S. K., Smith, C. L., Srivastava, R., Cantor, C. R., Weissman, S. M.
|
|
<strong>Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis.</strong>
|
|
Science 235: 1387-1390, 1987.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3029868/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3029868</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3029868" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.3029868" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="72" class="mim-anchor"></a>
|
|
<a id="Leinders-Zufall2004" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Leinders-Zufall, T., Brennan, P., Widmayer, P., Chandramani S., P., Maul-Pavicic, A., Jager, M., Li, X.-H., Breer, H., Zufall, F., Boehm, T.
|
|
<strong>MHC class I peptides as chemosensory signals in the vomeronasal organ.</strong>
|
|
Science 306: 1033-1037, 2004.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15528444/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15528444</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15528444" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.1102818" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="73" class="mim-anchor"></a>
|
|
<a id="Levine1985" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Levine, F., Erlich, H., Mach, B., Leach, R., White, R., Pious, D.
|
|
<strong>Deletion mapping of HLA and chromosome 6p genes.</strong>
|
|
Proc. Nat. Acad. Sci. 82: 3741-3745, 1985.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2987942/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2987942</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2987942" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.82.11.3741" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="74" class="mim-anchor"></a>
|
|
<a id="Lopez de Castro1982" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lopez de Castro, J. A., Strominger, J. L., Strong, D. M., Orr, H. T.
|
|
<strong>Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.</strong>
|
|
Proc. Nat. Acad. Sci. 79: 3813-3817, 1982.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6179086/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6179086</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6179086" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.79.12.3813" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="75" class="mim-anchor"></a>
|
|
<a id="Lutz2014" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Lutz, C. T.
|
|
<strong>Human leukocyte antigen Bw4 and Bw6 epitopes recognized by antibodies and natural killer cells.</strong>
|
|
Curr. Opin. Organ Transplant. 19: 436-441, 2014.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/24977435/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">24977435</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=24977435" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1097/MOT.0000000000000103" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="76" class="mim-anchor"></a>
|
|
<a id="MacDonald2000" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
MacDonald, K. S., Fowke, K. R., Kimani, J., Dunand, V. A., Nagelkerke, N. J. D., Ball, T. B., Oyugi, J., Njagi, E., Gaur, L. K., Brunham, R. C., Wade, J., Luscher, M. A., Krausa, P., Rowland-Jones, S., Ngugi, E., Bwayo, J. J., Plummer, F. A.
|
|
<strong>Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.</strong>
|
|
J. Infect. Dis. 181: 1581-1589, 2000.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/10823757/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">10823757</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=10823757" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1086/315472" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="77" class="mim-anchor"></a>
|
|
<a id="Malissen1982" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Malissen, M., Malissen, B., Jordan, B. R.
|
|
<strong>Exon/intron organization and complete nucleotide sequence of an HLA gene.</strong>
|
|
Proc. Nat. Acad. Sci. 79: 893-897, 1982.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6461010/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6461010</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6461010" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.79.3.893" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="78" class="mim-anchor"></a>
|
|
<a id="Mann1969" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Mann, D. L., Rogentine, G. N., Jr., Fahey, J. L., Nathenson, S. G.
|
|
<strong>Molecular heterogeneity of human lymphoid (HL-A) alloantigens.</strong>
|
|
Science 163: 1460-1462, 1969.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5773111/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5773111</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5773111" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.163.3874.1460" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="79" class="mim-anchor"></a>
|
|
<a id="Mayr1974" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Mayr, W. R., Mayr, D.
|
|
<strong>Analysis of the linkage between the HL-A loci and the genes of other markers.</strong>
|
|
Humangenetik 24: 129-133, 1974.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4139102/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4139102</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4139102" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="80" class="mim-anchor"></a>
|
|
<a id="McAulay2007" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
McAulay, K. A., Higgins, C. D., Macsween, K. F., Lake, A., Jarrett, R. F., Robertson, F. L., Williams, H., Crawford, D. H.
|
|
<strong>HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection.</strong>
|
|
J. Clin. Invest. 117: 3042-3048, 2007.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17909631/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17909631</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=17909631[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17909631" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1172/JCI32377" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="81" class="mim-anchor"></a>
|
|
<a id="McCormack2011" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., Sills, G. J., Marson, T., Jia, X., de Bakker, P. I. W., Chinthapalli, K., Molokhia, M., and 18 others.
|
|
<strong>HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.</strong>
|
|
New Eng. J. Med. 364: 1134-1143, 2011.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/21428769/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">21428769</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=21428769[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=21428769" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1056/NEJMoa1013297" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="82" class="mim-anchor"></a>
|
|
<a id="Messer1992" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Messer, G., Zemmour, J., Orr, H. T., Parham, P., Weiss, E. H., Girdlestone, J.
|
|
<strong>HLA-J, a second inactivated class I HLA gene related to HLA-G and HLA-A.</strong>
|
|
J. Immun. 148: 4043-4053, 1992.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1602142/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1602142</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1602142" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="83" class="mim-anchor"></a>
|
|
<a id="Morton1984" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Morton, C. C., Kirsch, I. R., Nance, W. E., Evans, G. A., Korman, A. J., Strominger, J. L.
|
|
<strong>Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization.</strong>
|
|
Proc. Nat. Acad. Sci. 81: 2816-2820, 1984.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6585830/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6585830</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6585830" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.81.9.2816" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="84" class="mim-anchor"></a>
|
|
<a id="Morton1977" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Morton, N. E., Rao, D. C., Lindsten, J., Hulten, M., Yee, S.
|
|
<strong>A chiasma map of man.</strong>
|
|
Hum. Hered. 27: 38-51, 1977.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/844885/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">844885</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=844885" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1159/000152850" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="85" class="mim-anchor"></a>
|
|
<a id="Mulley1983" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Mulley, J. C., Hay, J., Sheffield, L. J., Sutherland, G. R.
|
|
<strong>Regional localization for HLA by recombination with a fragile site at 6p23.</strong>
|
|
Am. J. Hum. Genet. 35: 1284-1288, 1983.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6650505/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6650505</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6650505" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="86" class="mim-anchor"></a>
|
|
<a id="Neijssen2005" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Neijssen, J., Herberts, C., Drijfhout, J. W., Reits, E., Janssen, L., Neefjes, J.
|
|
<strong>Cross-presentation by intercellular peptide transfer through gap junctions.</strong>
|
|
Nature 434: 83-88, 2005.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/15744304/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">15744304</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=15744304" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/nature03290" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="87" class="mim-anchor"></a>
|
|
<a id="Nejentsev2007" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Nejentsev, S., Howson, J. M. M., Walker, N. M., Szesko, J., Field, S. F., Stevens, H. E., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, L. M., and 8 others.
|
|
<strong>Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.</strong>
|
|
Nature 450: 887-892, 2007.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18004301/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18004301</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=18004301[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=18004301" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/nature06406" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="88" class="mim-anchor"></a>
|
|
<a id="Newell1994" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Newell, W. R., Trowsdale, J., Beck, S.
|
|
<strong>MHCDB--database of the human MHC.</strong>
|
|
Immunogenetics 40: 109-115, 1994.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8026859/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8026859</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8026859" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1007/BF00188173" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="89" class="mim-anchor"></a>
|
|
<a id="Orr1982" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Orr, H. T., Bach, F. H., Ploegh, H. L., Strominger, J. L., Kavathas, P., DeMars, R.
|
|
<strong>Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex.</strong>
|
|
Nature 296: 454-456, 1982.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7063041/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7063041</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7063041" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/296454a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="90" class="mim-anchor"></a>
|
|
<a id="Parham2012" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Parham, P., Norman, P. J., Abi-Rached, L., Guethlein, L. A.
|
|
<strong>Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.</strong>
|
|
Phil. Trans. Roy. Soc. London B Biol. Sci. 367: 800-811, 2012.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/22312047/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">22312047</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=22312047[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=22312047" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1098/rstb.2011.0266" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="91" class="mim-anchor"></a>
|
|
<a id="Patel1968" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Patel, R., Mickey, M. R., Terasaki, P. I.
|
|
<strong>Serotyping for homotransplantation of kidneys from unrelated donors.</strong>
|
|
New Eng. J. Med. 279: 501-506, 1968.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4876470/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4876470</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4876470" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1056/NEJM196809052791001" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="92" class="mim-anchor"></a>
|
|
<a id="Payne1964" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Payne, R., Tripp, M., Weigle, J., Bodmer, W. F., Bodmer, J. G.
|
|
<strong>A new leukocyte isoantigen system in man.</strong>
|
|
Cold Spring Harbor Symp. Quant. Biol. 29: 285-295, 1964.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/14278475/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">14278475</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=14278475" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1101/sqb.1964.029.01.031" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="93" class="mim-anchor"></a>
|
|
<a id="Polacek1983" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Polacek, L. A., Phillips, R. B., Hackbarth, S. A., Duquesnoy, R. J.
|
|
<strong>A linkage study of the HLA region using C-band heteromorphisms.</strong>
|
|
Clin. Genet. 23: 177-185, 1983.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6851213/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6851213</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6851213" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1399-0004.1983.tb01869.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="94" class="mim-anchor"></a>
|
|
<a id="Ragoussis1989" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Ragoussis, J., Bloemer, K., Pohla, H., Messer, G., Weiss, E. H., Ziegler, A.
|
|
<strong>A physical map including a new class I gene (cda12) of the human major histocompatibility complex (A2/B13 haplotype) derived from a monosomy 6 mutant cell line.</strong>
|
|
Genomics 4: 301-308, 1989.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2497062/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2497062</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2497062" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0888-7543(89)90334-0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="95" class="mim-anchor"></a>
|
|
<a id="Ragoussis1986" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Ragoussis, J., van der Bliek, A., Trowsdale, J., Ziegler, A.
|
|
<strong>Mapping of HLA genes using pulsed field gradient electrophoreses.</strong>
|
|
FEBS Lett. 204: 1-4, 1986.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3743756/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3743756</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3743756" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0014-5793(86)81376-x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="96" class="mim-anchor"></a>
|
|
<a id="Ramsuran2018" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, MP., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., and 14 others.
|
|
<strong>Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.</strong>
|
|
Science 359: 86-90, 2018. Note: Erratum: Science 365 (6452) 2019.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/29302013/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">29302013</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=29302013[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=29302013" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.aam8825" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="97" class="mim-anchor"></a>
|
|
<a id="Salter1989" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Salter, R. D., Norment, A. M., Chen, B. P., Clayberger, C., Krensky, A. M., Littman, D. R., Parham, P.
|
|
<strong>Polymorphism in the alpha(3) domain of HLA-A molecules affects binding to CD8.</strong>
|
|
Nature 338: 345-347, 1989.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2784196/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2784196</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2784196" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/338345a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="98" class="mim-anchor"></a>
|
|
<a id="Schunter1978" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Schunter, F., Wernet, P., Kompf, J., Bissbort, S., Gohler, F.
|
|
<strong>Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM. II. Segregation analysis.</strong>
|
|
Hum. Genet. 44: 321-331, 1978.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/730170/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">730170</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=730170" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1007/BF00394297" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="99" class="mim-anchor"></a>
|
|
<a id="Shiina2009" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Shiina, T., Hosomichi, K., Inoko, H., Kulski, J. K.
|
|
<strong>The HLA genomic loci map: expression, interaction, diversity and disease.</strong>
|
|
J. Hum. Genet. 54: 15-39, 2009.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/19158813/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">19158813</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=19158813" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/jhg.2008.5" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="100" class="mim-anchor"></a>
|
|
<a id="Shivdasani1993" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Shivdasani, R. A., Haluska, F. G., Dock, N. L., Dover, J. S., Kineke, E. J., Anderson, K. C.
|
|
<strong>Graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors.</strong>
|
|
New Eng. J. Med. 328: 766-770, 1993.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8437597/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8437597</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8437597" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1056/NEJM199303183281105" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="101" class="mim-anchor"></a>
|
|
<a id="Shukla1991" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Shukla, H., Gillespie, G. A., Srivastava, R., Collins, F., Chorney, M. J.
|
|
<strong>A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC.</strong>
|
|
Genomics 10: 905-914, 1991.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1916822/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1916822</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1916822" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0888-7543(91)90178-h" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="102" class="mim-anchor"></a>
|
|
<a id="Snell1981" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Snell, G. D.
|
|
<strong>Studies in histocompatibility.</strong>
|
|
Science 213: 172-178, 1981.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7017931/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7017931</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7017931" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.7017931" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="103" class="mim-anchor"></a>
|
|
<a id="Solheim1973" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Solheim, B. G., Bratlie, A., Sandberg, L., Staub-Nielsen, L., Thorsby, E.
|
|
<strong>Further evidence of a third HL-A locus.</strong>
|
|
Tissue Antigens 3: 439-453, 1973.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4130127/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4130127</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4130127" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1399-0039.1973.tb00514.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="104" class="mim-anchor"></a>
|
|
<a id="Strachan1987" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Strachan, T.
|
|
<strong>Molecular genetics and polymorphism of class I HLA antigens.</strong>
|
|
Brit. Med. Bull. 43: 1-14, 1987.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3315094/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3315094</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3315094" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1093/oxfordjournals.bmb.a072166" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="105" class="mim-anchor"></a>
|
|
<a id="Szpak2001" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Szpak, Y., Vieville, J.-C., Tabary, T., Naud, M.-C., Chopin, M., Edelson, C., Cohen, J. H. M., Dausset, J., de Kozak, Y., Pla, M.
|
|
<strong>Spontaneous retinopathy in HLA-A29 transgenic mice.</strong>
|
|
Proc. Nat. Acad. Sci. 98: 2572-2576, 2001.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11226280/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11226280</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=11226280[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11226280" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.051595998" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="106" class="mim-anchor"></a>
|
|
<a id="Teshima2002" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Teshima, T., Ordemann, R., Reddy, P., Gagin, S., Liu, C., Cooke, K. R., Ferrara, J. L. M.
|
|
<strong>Acute graft-versus-host disease does not require alloantigen expression on host epithelium.</strong>
|
|
Nature Med. 8: 575-581, 2002. Note: Erratum: Nature Med. 8: 1039 only, 2002.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12042807/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12042807</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12042807" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/nm0602-575" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="107" class="mim-anchor"></a>
|
|
<a id="Thorsby1970" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Thorsby, E., Sandberg, L., Lindholm, A., Kissmeyer-Nielsen, F.
|
|
<strong>The HL-A system: evidence of a third sub-locus.</strong>
|
|
Scand. J. Haemat. 7: 195-200, 1970.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5447964/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5447964</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5447964" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1600-0609.1970.tb01887.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="108" class="mim-anchor"></a>
|
|
<a id="Tiwari1985" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Tiwari, J. L., Terasaki, P. I.
|
|
<strong>HLA and Disease Associations.</strong>
|
|
New York: Springer-Verlag (pub.) 1985.
|
|
|
|
|
|
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="109" class="mim-anchor"></a>
|
|
<a id="Tragardh1979" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Tragardh, L., Rask, L., Wiman, K., Fohlman, J., Peterson, P. A.
|
|
<strong>Amino acid sequence of an immunoglobulin HLA antigen heavy chain domain.</strong>
|
|
Proc. Nat. Acad. Sci. 76: 5839-5842, 1979.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/118453/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">118453</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=118453" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.76.11.5839" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="110" class="mim-anchor"></a>
|
|
<a id="Trowsdale1991" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Trowsdale, J., Ragoussis, J., Campbell, R. D.
|
|
<strong>Map of the human MHC.</strong>
|
|
Immun. Today 12: 443-446, 1991.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1786080/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1786080</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1786080" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0167-5699(91)90017-n" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="111" class="mim-anchor"></a>
|
|
<a id="Trowsdale2001" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Trowsdale, J.
|
|
<strong>Genetic and functional relationships between MHC and NK receptor genes.</strong>
|
|
Immunity 15: 363-374, 2001.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11567627/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11567627</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11567627" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/s1074-7613(01)00197-2" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="112" class="mim-anchor"></a>
|
|
<a id="Ueta2007" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Ueta, M., Sotozono, C., Tokunaga, K., Yabe, T., Kinoshita, S.
|
|
<strong>Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese.</strong>
|
|
Am. J. Ophthal. 143: 367-368, 2007.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17258541/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17258541</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17258541" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/j.ajo.2006.09.029" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="113" class="mim-anchor"></a>
|
|
<a id="Uhr1979" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Uhr, J. W., Capra, J. D., Vitetta, E. S., Cook, R. G.
|
|
<strong>Organization of the immune response genes.</strong>
|
|
Science 206: 292-297, 1979.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/113876/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">113876</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=113876" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.113876" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="114" class="mim-anchor"></a>
|
|
<a id="Van Leeuwen1964" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Van Leeuwen, A., Eernisse, J. G., Van Rood, J. J.
|
|
<strong>A new leucocyte group with two alleles: leucocyte group five.</strong>
|
|
Vox Sang. 9: 431-446, 1964.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/14177432/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">14177432</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=14177432" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1423-0410.1964.tb03311.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="115" class="mim-anchor"></a>
|
|
<a id="Van Rood1988" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J., Amos, D. B.
|
|
<strong>In memoriam: Ruggero Ceppellini, 1917-1988.</strong>
|
|
Hum. Immun. 23: 1-3, 1988.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3056890/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3056890</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3056890" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/0198-8859(88)90012-2" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="116" class="mim-anchor"></a>
|
|
<a id="Van Rood1963" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J., Van Leeuwen, A.
|
|
<strong>Leukocyte grouping: a method and its application.</strong>
|
|
J. Clin. Invest. 42: 1382-1390, 1963.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/14060982/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">14060982</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=14060982" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1172/JCI104822" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="117" class="mim-anchor"></a>
|
|
<a id="Van Rood1969" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J.
|
|
<strong>Leucocyte grouping and organ transplantation.</strong>
|
|
Brit. J. Haemat. 16: 211-220, 1969.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5795218/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5795218</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5795218" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1111/j.1365-2141.1969.tb00396.x" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="118" class="mim-anchor"></a>
|
|
<a id="Van Rood1969" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J.
|
|
<strong>Tissue typing and organ transplantation.</strong>
|
|
Lancet 293: 1142-1146, 1969. Note: Originally Volume I.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4182701/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4182701</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4182701" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1016/s0140-6736(69)91659-6" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="119" class="mim-anchor"></a>
|
|
<a id="Van Someren1974" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Van Someren, H., Westerveld, A., Hagemeijer, A., Mees, J. R., Meera Khan, P., Zaalberg, O. B.
|
|
<strong>Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: evidence for synteny between the HL-A, PGM-3, ME-1, and IPO-B loci.</strong>
|
|
Proc. Nat. Acad. Sci. 71: 962-965, 1974.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4362641/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4362641</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4362641" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1073/pnas.71.3.962" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="120" class="mim-anchor"></a>
|
|
<a id="Walford1969" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Walford, R. L., Finkelstein, S., Hanna, C., Collins, Z.
|
|
<strong>Third sublocus in the HL-A human transplantation system.</strong>
|
|
Nature 224: 74-75, 1969.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/5822910/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">5822910</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=5822910" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1038/224074a0" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="121" class="mim-anchor"></a>
|
|
<a id="Weitkamp1973" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Weitkamp, L. R., Van Rood, J. J., Thorsby, E., Bias, W. B., Fotino, M., Lawler, S. D., Dausset, J., Mayr, W. R., Bodmer, J., Ward, F. S., Seignalet, J., Payne, R., Kissmeyer-Nielsen, F., Gatti, R. A., Sachs, J. A., Lamm, L. U.
|
|
<strong>The relation of parental sex and age to recombination in the HL-A system.</strong>
|
|
Hum. Hered. 23: 197-205, 1973.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/4760577/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">4760577</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=4760577" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1159/000152574" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="122" class="mim-anchor"></a>
|
|
<a id="Wolski1975" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Wolski, K. P., Schmid, F. R., Mittal, K. K.
|
|
<strong>Genetic linkage between the HL-A system and a deficit of the second component (C2) of complement.</strong>
|
|
Science 188: 1020-1022, 1975.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1145185/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1145185</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1145185" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1126/science.1145185" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="123" class="mim-anchor"></a>
|
|
<a id="Zareparsi2002" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Zareparsi, S., James, D. M., Kaye, J. A., Bird, T. D., Schellenberg, G. D., Payami, H.
|
|
<strong>HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease.</strong>
|
|
Neurology 58: 973-975, 2002.
|
|
|
|
|
|
[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/11914421/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">11914421</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=11914421" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
|
|
|
|
|
|
[<a href="https://doi.org/10.1212/wnl.58.6.973" target="_blank">Full Text</a>]
|
|
|
|
|
|
</p>
|
|
</div>
|
|
</li>
|
|
|
|
<li>
|
|
<a id="124" class="mim-anchor"></a>
|
|
<a id="Ziegler1989" class="mim-anchor"></a>
|
|
<div class="">
|
|
<p class="mim-text-font">
|
|
Ziegler, A., Ragoussis, J., Fonatsch, C., Weiss, E.
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<strong>A physical map of the human major histocompatibility (HLA) complex derived from a monosomy 6 mutant cell line. (Abstract)</strong>
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Cytogenet. Cell Genet. 51: 1116 only, 1989.
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<a href="#mimCollapseContributors" role="button" data-toggle="collapse"> Contributors: </a>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Ada Hamosh - updated : 08/14/2018
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<div class="row collapse" id="mimCollapseContributors">
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<span class="mim-text-font">
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Paul J. Converse - updated : 3/19/2015<br>Marla J. F. O'Neill - updated : 6/30/2014<br>Ada Hamosh - updated : 8/24/2011<br>Ada Hamosh - updated : 6/7/2011<br>Carol A. Bocchini - updated : 5/21/2009<br>Ada Hamosh - updated : 4/24/2008<br>Paul J. Converse - updated : 2/5/2008<br>Jane Kelly - updated : 11/21/2007<br>Cassandra L. Kniffin - updated : 10/30/2007<br>Ada Hamosh - updated : 2/1/2006<br>Ada Hamosh - updated : 3/3/2005<br>Victor A. McKusick - updated : 9/22/2003<br>Cassandra L. Kniffin - updated : 12/9/2002<br>Victor A. McKusick - updated : 10/11/2002<br>Paul J. Converse - updated : 5/31/2002<br>Victor A. McKusick - updated : 5/23/2002<br>Paul J. Converse - updated : 4/30/2001<br>Victor A. McKusick - updated : 3/12/2001<br>Ada Hamosh - updated : 3/24/1999
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<a id="creationDate" class="mim-anchor"></a>
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<div class="col-lg-2 col-md-2 col-sm-4 col-xs-4">
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Creation Date:
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Victor A. McKusick : 6/4/1986
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<span class="mim-text-font">
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carol : 03/24/2022
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<div class="row collapse" id="mimCollapseEditHistory">
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carol : 10/10/2019<br>carol : 05/20/2019<br>carol : 02/18/2019<br>alopez : 08/14/2018<br>carol : 04/26/2017<br>alopez : 10/07/2016<br>carol : 07/20/2015<br>mgross : 4/2/2015<br>mgross : 4/2/2015<br>mcolton : 3/19/2015<br>mgross : 11/12/2014<br>mcolton : 11/10/2014<br>carol : 7/8/2014<br>carol : 7/1/2014<br>mcolton : 6/30/2014<br>carol : 11/4/2013<br>terry : 3/14/2013<br>mgross : 12/16/2011<br>alopez : 8/25/2011<br>terry : 8/24/2011<br>alopez : 6/13/2011<br>alopez : 6/13/2011<br>alopez : 6/13/2011<br>terry : 6/7/2011<br>terry : 4/21/2011<br>carol : 10/21/2010<br>joanna : 8/18/2010<br>mgross : 7/26/2010<br>mgross : 3/25/2010<br>terry : 12/16/2009<br>carol : 5/28/2009<br>carol : 5/27/2009<br>carol : 5/21/2009<br>terry : 1/14/2009<br>alopez : 5/8/2008<br>terry : 4/24/2008<br>mgross : 2/5/2008<br>mgross : 2/5/2008<br>carol : 11/21/2007<br>wwang : 11/12/2007<br>ckniffin : 10/30/2007<br>alopez : 2/2/2006<br>terry : 2/1/2006<br>alopez : 1/18/2006<br>alopez : 7/20/2005<br>mgross : 6/17/2005<br>terry : 3/11/2005<br>alopez : 3/4/2005<br>terry : 3/3/2005<br>ckniffin : 4/30/2004<br>cwells : 11/7/2003<br>cwells : 11/5/2003<br>tkritzer : 9/25/2003<br>tkritzer : 9/23/2003<br>tkritzer : 9/22/2003<br>terry : 9/8/2003<br>carol : 12/16/2002<br>carol : 12/16/2002<br>tkritzer : 12/13/2002<br>ckniffin : 12/9/2002<br>tkritzer : 10/28/2002<br>tkritzer : 10/17/2002<br>terry : 10/11/2002<br>alopez : 5/31/2002<br>alopez : 5/28/2002<br>terry : 5/23/2002<br>mgross : 4/30/2001<br>mgross : 4/30/2001<br>carol : 4/2/2001<br>mcapotos : 3/30/2001<br>mcapotos : 3/21/2001<br>terry : 3/12/2001<br>carol : 2/19/2000<br>kayiaros : 2/17/2000<br>carol : 8/26/1999<br>alopez : 3/24/1999<br>alopez : 5/29/1998<br>mark : 10/10/1997<br>mark : 10/10/1997<br>mark : 8/6/1997<br>mark : 8/6/1997<br>mark : 8/6/1997<br>mark : 9/12/1996<br>terry : 9/4/1996<br>mark : 7/30/1995<br>carol : 12/13/1994<br>terry : 8/26/1994<br>davew : 8/10/1994<br>warfield : 4/8/1994<br>pfoster : 3/31/1994
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<span class="mim-font">
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<strong>*</strong> 142800
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<h3>
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<span class="mim-font">
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MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, A; HLA-A
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<span class="mim-font">
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<em>Alternative titles; symbols</em>
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<span class="mim-font">
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HLA-A HISTOCOMPATIBILITY TYPE
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<span class="mim-font">
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Other entities represented in this entry:
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<span class="h3 mim-font">
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MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, H PSEUDOGENE, INCLUDED; HLA-H, INCLUDED
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<span class="h4 mim-font">
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MAJOR HISTOCOMPATIBILITY COMPLEX, CLASS I, J PSEUDOGENE, INCLUDED; HLA-J, INCLUDED
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<span class="mim-text-font">
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<strong><em>HGNC Approved Gene Symbol: HLA-A</em></strong>
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<strong>
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<em>
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Cytogenetic location: 6p22.1
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Genomic coordinates <span class="small">(GRCh38)</span> : 6:29,942,532-29,945,870 </span>
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</em>
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</strong>
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<span class="small">(from NCBI)</span>
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</span>
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<h4>
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<span class="mim-font">
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<strong>Gene-Phenotype Relationships</strong>
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</span>
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<div>
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<table class="table table-bordered table-condensed small mim-table-padding">
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<thead>
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<tr class="active">
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<th>
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Location
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</th>
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<th>
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Phenotype
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</th>
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<th>
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Phenotype <br /> MIM number
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</th>
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<th>
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Inheritance
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<th>
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Phenotype <br /> mapping key
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<span class="mim-font">
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6p22.1
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<span class="mim-font">
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{Hypersensitivity syndrome, carbamazepine-induced, susceptibility to}
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</span>
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</td>
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<td>
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<span class="mim-font">
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608579
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</td>
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<td>
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<span class="mim-font">
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<td>
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<span class="mim-font">
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3
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<span class="mim-font">
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<strong>TEXT</strong>
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<span class="mim-font">
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<strong>Description</strong>
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</div>
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<span class="mim-text-font">
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<p>The human major histocompatibility complex (MHC) has been divided into 3 regions on chromosome 6p21.3: class II (centromeric), class III, and class I (telomeric), with extended class I and class II regions on either side. The MHC encodes highly polymorphic proteins, many of which are associated with the immune system. The products of classical polymorphic class I genes, human leukocyte antigen-A (HLA-A), HLA-B (142830), and HLA-C (142840), interact with T-cell receptor (TCR; see 186880) molecules, as well as killer immunoglobulin-like receptors (KIRs; see 604936) expressed on natural killer cells and some T cells (review by Trowsdale, 2001). </p><p>Evidence from amino acid sequences suggests an evolutionary relatedness of transplantation antigens, immunoglobulins and beta-2-microglobins (Tragardh et al., 1979). Both the class I MHC antigens (A, B, and C) and the class II antigens DR and DC1 are polymorphic 2-chain cell surface glycoproteins; they are recognized by different subsets of T cells and have different functions, tissue distributions, and structures. The light chain of class I antigens is beta-2-microglobulin (B2M; 109700), which is coded by chromosome 15. The heavy chain, coded by chromosome 6, has a molecular mass of 44,000 and is made up of 3 N-terminal extracellular domains of 90 amino acids each, a small hydrophobic membrane-spanning segment and a small hydrophilic intracellular C-terminal domain. The 2 N-terminal domains are polymorphic, bear the carbohydrate and have no sequence homology with immunoglobulin. The third domain, closest to the membrane, and the 11.6-kD B2M light chain are highly conserved and have strong sequence homology with immunoglobulin. </p>
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<h4>
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<span class="mim-font">
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<strong>Gene Structure</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>The sequence of a human class I gene was determined by Malissen et al. (1982). As in mouse, the domain organization of the HLA protein is reflected precisely in the exon-intron structure of the gene: separate exons encode the signal peptide, each of the 3 external domains and the transmembrane region, and 3 exons encode the small cytoplasmic domain. (See Hood et al., 1982.) </p>
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</span>
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<div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Mapping</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Studying a family with a pericentric inversion, Lamm et al. (1974) confirmed assignment of the HLA complex to chromosome 6. In a familial 6-21 translocation (Borgaonkar et al., 1973), Borgaonkar and Bias (1974) could show that HLA is proximal to 6p22. Francke and Pellegrino (1977) concluded that HLA is distal to 6p21. Thus, rather precise localization is possible. Kompf et al. (1978) and Schunter et al. (1978) presented evidence suggesting that PGM3 (172100) is on the HLA-A side of MHC rather than on the HLA-B side, as had previously been thought. From study of a 3-generation family segregating for variation of the centromeric heterochromatic region of chromosome 6p11 (6ph), Bakker et al. (1979) concluded that the HLA cluster and 6ph are about 6 cM apart (with peak lod score of 3.466 at a recombination fraction of 0.0588; 95% confidence limits 0-0.18), that GLO is on the centromeric side of HLA, that PGM-3 is not on the short arm, and that HLA-B is closer to the centromere than HLA-A. </p><p>In a child partially trisomic for chromosome 6, Berger et al. (1979) discovered 3 haplotypes for HLA-A, -B and -C from the mother. The patient had only 2 HLA-DR specificities. The region was assigned to 6p2105. </p><p>By in situ hybridization, Morton et al. (1984) showed that class I HLA determinants (HLA-A, -B, -C) are located in 6p21.3 and class II determinants in 6p21.1. The findings suggested that one can resolve loci separated by as little as 1 cM by this technique. Using C-band heteromorphisms in linkage studies, Polacek et al. (1983) estimated the centromere-HLA distance as 14 cM with 95% confidence limits of 0.012 and 0.263. Reference to the chiasma map of Morton et al. (1977) suggested that a map distance of 14 cM corresponds to 6p21-6p22, the region where HLA is mapped physically. Mulley et al. (1983) estimated that the genetic distance of HLA from fragile site 6p23 is 20 cM, with a lower 95% probability limit of 8.5 cM, placing HLA proximal to the midpoint of 6p22. This agreed closely with the other regionalization of HLA at 6p21.3. The work suggests that the fragile site does not distort recombination and that the genetic determinant predisposing to expression of the fragile site is situated at the fragile site. </p><p>By FISH, Hirai et al. (1991) placed the MHC loci on 5p21.3 in the chimpanzee, which corresponds precisely to their location on human chromosome 6p21.3. The chimpanzee has 48 chromosomes with 2 pairs of group D-like chromosomes which, in the human, are represented by the 2 arms of chromosome 2. The MHC loci were shown by Hirai et al. (1991) to be located on the long arm of the rhesus monkey chromosome 5; by study of somatic cell hybrids, the MHC loci had been thought to be on chromosome 2 of the rhesus. </p><p>The T-locus in the mouse is on the same chromosome as the H-2 locus and is likewise highly complex in its genetics (Gluecksohn-Waelsch and Erickson, 1970). The linkage of the T and H-2 loci may have significance since the T-locus is concerned with development, and surface antigens of the sort coded by H-2 (and HLA) are also important in development. The MHC antigens are differentiation antigens. Because of the close homologies, information on MHC of the mouse is of great relevance (Klein, 1979). </p><p>Lawrance et al. (1987) demonstrated the feasibility of megabase-scale mapping of the HLA gene complex by pulsed-field gel electrophoresis. With previous methods, there existed a 'resolution gap' between molecular cloning experiments and meiotic linkage analyses. The enzymes used in the study were initially selected as those which recognize 8-basepair cleavage sites and/or contain CpG in their recognition sequences. Because of the rarity of CpG in mammalian genomes, these enzymes are expected to generate fragments that are much larger than would be predicted statistically in random sequence DNA. Enzyme restriction endonucleases used were NotI, SalI, and NruI. The data indicated that the HLA complex spans over 3 million bases (Ragoussis et al., 1986; Lawrance et al., 1987). </p><p>To avoid problems of interpretation resulting from heterozygosity, Ragoussis et al. (1989) used a monosomy 6 mutant cell line to establish a molecular map of the MHC region. Field-inversion gel electrophoresis and Southern blotting techniques were used. The HLA complex has a length of 4,200 kb. Five HTF islands were positioned on the map: between DX (HLA-DQA1; 613503) and DOB, close to DOB; between DRA and C4; between C2 and TNFA, close to C2; within 50 kb telomeric to HLA-C; and within 200 kb telomeric to HLA-A. The total length of the MHC region represents about 2.5% of the total length of chromosome 6. The class I region has a size of about 2,000 kb. The class II region has a size of 1,000 kb and is separated from the class I region by about 1,200 kb. </p><p>Ziegler et al. (1989) presented a physical map of the human MHC locus derived from pulsed field gel electrophoresis data.</p><p>Trowsdale et al. (1991) and Campbell and Trowsdale (1993) provided maps compiling the physical mapping and cloning data related to the entire MHC region of the human. </p><p>Abderrahim et al. (1994) isolated 53 YACs with an average size of 490 kb and organized them into a single large contig covering more than 4,000 kb spanning the entire MHC region. </p><p><strong><em>Class I HLA Pseudogenes</em></strong></p><p>
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HLA-H is a class I HLA pseudogene. (The designation HLAH, rather than HFE (613609), has been used by some for the gene mutant in hereditary hemochromatosis (235200). HLAHP may an appropriate symbol for this presumed pseudogene, thus avoiding confusion.) By a combination of cosmid cloning, chromosomal jumping, and pulsed field gel electrophoresis (PFGE), Shukla et al. (1991) performed fine mapping of the HLA-A subregion of the major histocompatibility complex. They demonstrated that the Qa-like HLA-G class I gene (142871) is within 100 kb of HLA-H. Furthermore, these 2 genes are linked to HLA-A, with HLA-H lying no more than 200 kb from HLA-A. The data were interpreted as supporting the existence of a Qa-like subregion composed of nonclassic HLA class I genes within the human MHC and situated telomeric to the HLA-A locus. HLA-H is probably a pseudogene due to an in-frame termination codon in its fourth exon; however, at the RNA level, the gene is expressed. The human Qa-like subregion appears to be less densely populated with genes than is its mouse equivalent. </p><p>HLA-J is another class I HLA pseudogene. Nucleotide sequence comparisons show that the HLA-A, H, J, and G genes form a well-defined group of 'HLA-A-related' loci (Messer et al., 1992). Evolutionary relationships suggested that the 4 modern loci were formed by successive duplications from a common ancestral gene. It is thought that one intermediate locus gives rise to A and H, the other to G and J. </p>
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</span>
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<div>
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<br />
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</div>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Evolution</strong>
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</span>
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</h4>
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</div>
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<span class="mim-text-font">
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<p>Bodmer (1986) suggested that the gene products of the major histocompatibility complex be referred to as histoglobulins, a term parallel to immunoglobulins, with which they share an evolutionary origin. The chimpanzee has 2 main allelic series of leukocyte antigens (Balner et al., 1974) and the Rhesus monkey has histocompatibility-linked immune-response genes (Dorf et al., 1974). The existence of one or more Ir (immune response) loci in man is suggested by the comparative studies of the MHC of mice and lower primates; furthermore, 2 separate loci in the MHC code for B-lymphocyte alloantigens (see 146880). </p><p>Klein and Figueroa (1986) reviewed the evolution of the major histocompatibility complex, using the designation Mhc for the mouse system. They reproduced the figure of the banding pattern of mouse chromosomes as revealed by Giemsa staining following treatment with trypsin and chymotrypsin. They concluded that the Mhc region represents a 'frozen linkage group;' that the complement and P-450 genes were transferred to the Mhc region from another chromosome at the time the beta-2-microglobulin gene separated from the Mhc cluster and that they are therefore foreign elements in the Mhc region and not functional parts of Mhc proper; and that class Ib loci (Qa and Tla) constitute the junkyard of the Mhc region, these being either pseudogenes or on the way to becoming pseudogenes. Figueroa et al. (1988) described MHC polymorphism that must have arisen before the separation of mice and rats from a common ancestor more than 10 million years ago. Similarly, Lawlor et al. (1988) found close similarity in the HLA-A and HLA-B (142830) alleles of human and chimpanzee. Indeed, individual alleles were found to be more closely related to individual chimpanzee alleles than to other HLA-A or -B alleles. Thus, again, a considerable proportion of contemporary HLA-A and -B polymorphism existed before divergence of the chimpanzee and human lines. </p><p>MHC class I molecules play an essential role in the immune defense against intracellular infections. The hallmark of the MHC is its extensive degree of polymorphism at the population level. However, de Groot et al. (2002), comparing MHC class I gene intron variation, found that chimpanzees have experienced a severe repertoire reduction at the orthologs of the HLA-A, -B, and -C loci. The loss of variability predated the (sub)speciation of chimpanzees and did not affect other known gene systems. Therefore, the selective sweep in the MHC class I gene may have resulted from a widespread viral infection. Based on their results and the fact that chimpanzees have a natural resistance to the development of AIDS, de Groot et al. (2002) hypothesized that the selective sweep was caused by the chimpanzee-derived simian immunodeficiency virus, the closest relative of HIV-1, or a closely related retrovirus. Hence, contemporary chimpanzee populations represent the offspring of AIDS-resistant animals, the survivors of an HIV-like pandemic that took place in the distant past. </p><p>Danchin et al. (2003) claimed to have confirmed for the first time with robust evidence the existence of a region of conserved synteny between the human genome and the Drosophila genome. Evolutionarily conserved synteny involved the human MHC and paralogous regions. The authors identified 19 conserved genes between these 2 species in a Drosophila genomic region of less than 2 Mb. The statistical analysis of the distribution of these 19 genes between the 2 genomes showed that it could not be explained by chance. Danchin et al. (2003) suggested that their study constituted a first step toward the reconstruction of the genome of Urbilateria (the ancestor of all bilaterians) and allowed for a better understanding of the evolutionary history of the human genome as well as other metazoan genomes. </p>
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<strong>Gene Function</strong>
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<p>The usefulness of HLA typing for selection of kidney donors was demonstrated by Patel et al. (1968). </p><p>Salter et al. (1989) demonstrated that the binding of CD8 (186910) glycoprotein on the surface of cytotoxic T-lymphocytes is mediated through the alpha-3 domain of class I MHC molecules. They demonstrated that 2 HLA-A alleles, which do not bind CD8, have a valine for alanine substitution at position 245. Further studies using site-directed mutagenesis demonstrated that this substitution in the alpha-3 domain mediates the CD8 binding. </p><p>Although the major histocompatibility complex (MHC) is named for its association with graft rejection, clearly the prevention of tissue engraftment between individuals is not the raison d'etre for MHC-encoded molecules. Through the progress of knowledge concerning MHC and the evolution of concepts over a period of more than 50 years (see outline by Colombani, 1992), it is now recognized that the products of the MHC genes are antigen-presenting molecules (APM) designed for the presentation of antigen fragments (peptides) to the T-cell receptor, thus participating in the immune response (Hedrick, 1992). Indeed, Colombani (1992) suggested that instead of MHC the complex should be called MPHC, for major presentation and histocompatibility complex. </p><p>MHC class I molecules present peptides that are derived from endogenous proteins. These antigens can also be transferred to professional antigen-presenting cells in a process called crosspresentation, which precedes initiation of a proper T-cell response. Neijssen et al. (2005) tested whether peptides can be transferred directly from the cytoplasm of one cell into the cytoplasm of its neighbor through gap junctions. They demonstrated that peptides with a molecular mass of up to approximately 1,800 diffuse intercellularly through gap junctions unless a 3-dimensional structure is imposed. This intercellular peptide transfer causes cytotoxic T-cell recognition of adjacent, innocent bystander cells as well as activated monocytes. Gap junction-mediated peptide transfer is restricted to a few coupling cells owing to the high cytosolic peptidase activity. Neijssen et al. (2005) presented a mechanism of antigen acquisition for crosspresentation that couples the antigen presentation system of 2 adjacent cells and is lost in most tumors: gap junction-mediated intercellular peptide coupling for presentation by bystander MHC class I molecules and transfer to professional antigen-presenting cells for crosspriming. </p><p>Transfusion-associated graft-versus-host disease (GVHD; see 614395) is fatal in most cases. Since gamma irradiation of cellular blood components before transfusion can prevent the development of transfusion-associated GVHD, identification of susceptible hosts is critical. Shivdasani et al. (1993) reported a case of transfusion-associated GVHD in the US that occurred after platelets from an HLA-homozygous donor, born of nonconsanguineous parents, were transfused into an immunocompetent patient who was heterozygous for the donor's haplotype. Because the likelihood that donors who are homozygous for a given HLA haplotype will provide blood for unrelated recipients who share that haplotype has been judged to be remote in the US, the general use of gamma irradiation of cellular blood components has not been recommended. Shivdasani et al. (1993) suggested the existence of an HLA-related predisposition to transfusion-associated GVHD in immunocompetent patients and recommended that the guidelines for the irradiation of blood components be reassessed. </p><p>Modulators of immune regulation 1 and 2 (MIR1 and MIR2) are E3 ubiquitin ligases encoded by Kaposi sarcoma-associated herpesvirus that mediate the ubiquitination of MHC I molecules and subsequent internalization. Cadwell and Coscoy (2005) found that MIR1 but not MIR2 promoted downregulation of MHC I molecules lacking lysine residues in their intracytoplasmic domain. In the presence of MIR1, these MHC I molecules were ubiquitinated, and their association with ubiquitin was sensitive to beta-2-mercaptoethanol, unlike lysine-ubiquitin bonds. This form of ubiquitination required a cysteine residue in the intracytoplasmic tail of MHC I molecules. An MHC I molecule containing a single cysteine residue in an artificial glycine and alanine intracytoplasmic domain was endocytosed and degraded in the presence of MIR1. Thus, Cadwell and Coscoy (2005) concluded that ubiquitination can occur on proteins lacking accessible lysines or an accessible N terminus. </p><p>Ramsuran et al. (2018) analyzed 9,763 HIV-infected individuals from 21 cohorts and found that higher HLA-A levels confer poorer control of HIV. Elevated HLA-A expression provides enhanced levels of an HLA-A-derived signal peptide that specifically binds and determines expression levels of HLA-E (143010), the ligand for the inhibitory NKG2A (see 161555) natural killer cell receptor. HLA-B (142830) haplotypes that favor NKG2A-mediated NK cell licensing (i.e., education) exacerbate the deleterious effect of high HLA-A on HIV control, consistent with NKG2A-mediated inhibition impairing NK cell clearance of HIV-infected targets. </p>
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<strong>Molecular Genetics</strong>
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<p>Lawlor et al. (1991) used PCR to amplify brain DNA from the Windover pond of central Florida, which contains human remains about 7,500 years old. From 1 individual they characterized segments from 6 nuclear genes: that for beta-2-microglobulin and 5 members of the class I HLA heavy chain gene family. Distinctive patterns of nucleotide substitution in the cloned heavy chain gene segments permitted tentative assignment of the HLA-A,B type of the ancient individual. One of the HLA-A alleles that was found is observed at high frequency in the modern Amerindian population. </p><p>Carrington et al. (1999) reported that the extended survival of 28 to 40% of HIV-1-infected Caucasian patients who avoided AIDS for 10 or more years (see 609423) could be attributed to their being fully heterozygous at HLA class I loci, to lacking the AIDS-associated alleles B*35 and Cw*04, or to both. </p><p>MacDonald et al. (2000) examined the influence of HLA types on susceptibility to HIV-1 infection in a population of chronically and highly exposed commercial sex workers enrolled in a prospective study in Nairobi, Kenya. MHC class I serologically defined alleles HLA-A2, HLA-A28, and HLA-B18 were associated with decreased risk of HIV-1 infection in this population, while HLA-A23 was associated with increased risk. Molecular subtyping identified a supertype, which consisted of the HLA-A2 subtypes HLA-A*0202, -A*0205, and -A*0214 and an HLA-A28 subtype, HLA-A*6802, that was associated with a significantly decreased rate of HIV-1 seroconversion. Molecular typing for MHC class II alleles revealed a significantly decreased risk of HIV-1 seroconversion associated with the HLA-DRB1*0102 allele of the HLA-DRB1*01 determinant. MacDonald et al. (2000) noted that in this cohort resistance to HIV-1 infection was associated with immunologic responses to the virus but not with chemokine receptor polymorphisms (see CCR2; 601267). They proposed that the A2/6802 supertype and the DRB1*01 determinant may mediate protection against HIV-1 through the presentation and restriction of conserved epitopes; however, these alleles are neither completely necessary nor sufficient for resistance. </p><p>Szpak et al. (2001) noted that the human MHC class I specificity HLA-A29 has been observed in nearly all patients (95.8%) with birdshot chorioretinopathy (BSCR; 605808) compared with 7% in healthy controls. BSCR is characterized by multiple small, cream-colored lesions, symmetrically scattered mainly around the optic disc and radiating toward the equator. These depigmented spots, the most distinctive sign of the syndrome, appear at the level of the retinal pigment epithelium but, on occasion, suggest an even deeper infiltration. In an attempt to develop an animal model of HLA-A29-associated disease, Szpak et al. (2001) produced transgenic mice expressing HLA-A29 molecules. They found that an eye disorder spontaneously arising in these transgenic mice included many of the features of HLA-A29-associated BSCR in humans. In humans the retinal vasculopathy and inflammatory signs associated with the funduscopic findings lead regularly to visual loss. </p><p>Cardoso et al. (2002) found linkage disequilibrium between all HLA-A29-containing haplotypes and the hemochromatosis-producing H63D mutation (613609.0002), favoring the hypothesis of a coselection of H63D and HLA-A29. They considered that support and insight were provided by the finding of significantly higher CD8+ T-lymphocyte counts in subjects simultaneously carrying the H63D mutation and the HLA-A29 allele. </p><p>Zareparsi et al. (2002) noted that several studies had found an increased frequency of the HLA-A2 allele in patients with early-onset Alzheimer disease (AD; 104300) and that others had found an association between the A2 allele and earlier age of onset of AD. Among 458 unrelated patients with AD, Zareparsi et al. (2002) found that HLA-A2 homozygotes had an average 5-year earlier age of onset than either A2 heterozygotes or those without A2. The risk associated with the A2 homozygous genotype was 2.6 times greater in patients with early-onset AD (less than age 60) than in those with late-onset AD, reflecting a dosage effect. These effects were present regardless of gender, familial or sporadic nature of the disease, or presence or absence of the APOE (107741) E4 allele. The authors suggested that the A2 allele may have a role in regulating an immune response in the pathogenesis of AD or that there may be a responsible gene in close linkage to A2. </p><p>In a study of 40 Japanese patients with SJS/toxic epidermal necrolysis (TEN; 608579) with ocular complications and 113 healthy Japanese individuals, Ueta et al. (2007) found a significant association with HLA-A*0206 (Pc less than .0005, OR = 5.1), but not with HLA-B, HLA-C, or other HLA-A alleles tested. </p><p>Infectious mononucleosis (IM) is an immunopathologic disease caused by Epstein-Barr virus (EBV) that occurs in young adults and is a risk factor for Hodgkin lymphoma (236000). McAulay et al. (2007) analyzed 2 microsatellite markers, D6S510 and D6S265, and 2 SNPs, rs253088 and rs6457110, from the HLA class I region in patients with acute IM and in asymptomatic EBV-seropositive and -seronegative individuals. Alleles of both microsatellite markers were significantly associated with development of IM, and allele A of rs253088 and allele T of rs6457110 were significantly more frequent in patients with IM than in EBV-seronegative individuals. IM patients with the associated microsatellite alleles had fewer lymphocytes, more neutrophils, and higher EBV titers than IM patients lacking the alleles. McAulay et al. (2007) proposed that HLA class I polymorphisms predispose patients to development of IM upon primary EBV infection, possibly due to genetic variation in T-cell responses and the level of viral persistence. </p><p>Nejentsev et al. (2007) used several large type I diabetes (222100) data sets to analyze a combined total of 1,729 polymorphisms, and applied statistical methods--recursive partitioning and regression--to pinpoint disease susceptibility to the MHC class I genes HLA-B (142830) and HLA-A (risk ratios greater than 1.5; P(combined) = 2.01 x 10(-19) and 2.35 x 10(-13), respectively) in addition to the established associations of the MHC class II genes HLA-DQB1 (604305) and HLA-DRB1 (142857). Nejentsev et al. (2007) suggested that other loci with smaller and/or rarer effects might also be involved, but to find these future searches must take into account both the HLA class II and class I genes and use even larger samples. Taken together with previous studies, Nejentsev et al. (2007) concluded that MHC class I-mediated events, principally involving HLA-B*39, contribute to the etiology of type I diabetes. </p><p>In a collaborative GWAS involving 9,772 cases of European descent collected by 23 research groups working in 15 different countries, the International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2 (2011) replicated almost all of the previously suggested associations and identified at least a further 29 novel susceptibility loci for multiple sclerosis (126200). Within the MHC the International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2 (2011) refined the identity of the HLA-DRB1 risk alleles as DRB1*1501 (142857.0002) and DRB1*1303, and confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. Immunologically relevant genes were significantly overrepresented among those mapping close to identified loci and particularly implicated T helper cell differentiation in the pathogenesis of multiple sclerosis. The International Multiple Sclerosis Genetics Consortium and Wellcome Trust Case Control Consortium 2 (2011) confirmed that variation in the HLA-A gene underlies the independent protective effect attributable to the class I region. HLA allele HLA*0201 has a combined odds ratio (OR) of 0.73 across independent populations of European descent. </p><p>Lutz (2014) reviewed HLA Bw4 and Bw6. As a result of transplantation, blood transfusion, or pregnancy, people are immunized and produce antibodies to 'private' epitopes, which are shared by few other HLA allele products, or 'public' epitopes, which are encoded by many HLA alleles. The most prominent public epitopes are Bw4 and Bw6. Either the Bw4 or the Bw6 epitope is expressed by virtually all HLA-B molecules, and Bw4 is also found on a few HLA-A proteins. Parham et al. (2012) reported that Bw4, along with HLA-A3, HLA-A11, HLA-C1, and HLA-C2, is a KIR (e.g., KIR3DL1; 604946) ligand. Habegger de Sorrentino et al. (2013) listed 14 HLA-B alleles and 4 HLA-A alleles expressing Bw4 epitopes. </p><p><strong><em>Reviews</em></strong></p><p>
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Gruen et al. (1996) applied cDNA hybridization selection to 9 YACs spanning 3 Mb of genomic DNA from a region centromeric to HLA-A to the histone cluster that lies telomeric to the major histocompatibility complex. In addition to class I genes and pseudogenes, they described over 63 genes and 23 additional expressed sequence tags distributed throughout the region. Many of the full-length genes belong to gene families. Prominent among these was a group of genes encoding proteins showing homology to the C-terminal sequences of butyrophilin and an additional group of zinc finger genes. Gruen et al. (1996) also detected several previously undefined genes that are specifically expressed in cells of the immune system, indicating a more complex role of the MHC in the immune response than had been appreciated. </p><p>Shiina et al. (2009) provided an extensive review of what they termed the 'HLA super-locus,' a genomic region on 6p21 that contains the 6 classical transplantation HLA genes and at least 132 protein coding genes that have important roles in the regulation of the immune system as well as some other fundamental molecular and cellular processes. The review included a tabulation of MHC monogenic and polygenic disease associations. </p><p><strong><em>Major Histocompatibility Complex Database</em></strong></p><p>
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Newell et al. (1994) described a database of the human major histocompatibility complex, MHCDB, which allows access, retrieval, and display of physical and genetic data relating to the human MHC. The contents of the database included: (1) location of over 100 genes and other markers; (2) location of over 250 YAC and cosmid clones; (3) 150 kb of genomic DNA sequence including full annotation (exon/intron boundaries, repeats, promoters, etc.); (4) cDNA sequences of currently known class I and class II alleles; and (5) accompanying descriptive data--references, comments, laboratory addresses, and so on. </p>
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<p>Teshima et al. (2002) transferred bone marrow into irradiated wildtype and MHC class II-deficient recipient mice. Donors and recipients differed at only a single class II allele. The class II-knockout recipient chimeras, therefore, expressed class II only on hemopoietic cells or antigen-presenting cells (APCs). CD4+ T lymphocytes expressing CD25 (147730) and CD49 expanded in the wildtype but not the class II-null mice. Wildtype mice also had increased serum Ifng (147570). All wildtype but no knockout mice succumbed to acute graft-versus-host disease (GvHD) by day 7 after transplant. Other experiments showed that host APC, but not epithelial cell, class II alloantigens are sufficient to induce CD4+ T cell expansion, cytokine secretion, and lethal GvHD. Furthermore, blockade of inflammatory cytokines TNF (191160) and IL1B (147720) can block the effector phase of acute GvHD without blocking CD4 T cell expansion. Similarly, in mice lacking class I expression, host APC alloantigen expression is required for the development of CD8+ T lymphocyte-mediated GvHD. Fatal disease onset, but not target organ damage in surviving mice, is reduced in mice lacking epithelial cell class I expression. Teshima et al. (2002) concluded that host APCs are sufficient in both activation and effector phases of acute GvHD and that alloantigen expression on target cells is not always required, particularly for CD4-mediated disease. They proposed that blockade of inflammatory cytokines could be beneficial in clinical bone marrow transplantation by preventing the toxicity of GvHD while allowing beneficial graft-versus-leukemia effects. </p><p>Leinders-Zufall et al. (2004) showed that small peptides that serve as ligands for MHC class I molecules function also as sensory stimuli for a subset of vomeronasal sensory neurons located in the basal G-alpha-o- (139311) and V2R receptor (see 605234)-expressing zone of the vomeronasal epithelium. In behaving mice, the same peptides function as individuality signals underlying mate recognition in the context of pregnancy block. MHC peptides constitute a previously unknown family of chemosensory stimuli by which MHC genotypic diversity can influence social behavior. </p>
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<strong>History</strong>
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<p>Strachan (1987) reviewed the molecular genetics of class I HLA antigens. The genes for the classical HLA-A, -B, and -C heavy chains are members of a large multigene family of highly related sequences. </p><p>Bach and Amos (1967) concluded that a single locus with 15 or more alleles controls reactivity in mixed leukocyte culture tests, and that genes at this locus also control most of the specificities measured by cytotoxic antiserums to leukocytes. This may be the major histocompatibility locus in man. Bernard (1967) called discovery of the Hu-1 (now called HLA) system as important an event in biology as discovery of the ABO and Rh systems, perhaps more important. </p><p>By gel filtration, Mann et al. (1969) separated soluble preparations of HLA alloantigens into components having either 'LA' specificity or 'FOUR' specificity. This may indicate that the HLA 'locus' is a region with several different cistrons. Furthermore, family data indicate the existence of 2 'segregant series.' Antigens 1, 2, 3, 9, 10 and 11 are mutually exclusive members of one allelic series whereas a different array of antigens constitutes a second series (Bach and Bach, 1970). The relation of the isoantigenic variants identified in human fibroblast cultures to the HLA system is not known. Both the HLA system in man and the H-2 system in mice seem to have haploid expression in sperm. </p><p>Recombination has been observed within the HLA system (Bodmer et al., 1970). The LA and 'FOUR' loci are very closely linked (Kissmeyer-Nielsen and Thorsby, 1970). The ratio of female to male recombination fractions is 1.6 (Lamm et al., 1971). The HLA loci are linked to the PGM3 locus, the distance being about 0.15 morgans in females (Lamm et al., 1971). Lamm et al. (1972) reviewed the evidence that the 'FOUR' and LA loci are about 1 centimorgan apart and presented evidence that the PGM-3 locus is on the 'FOUR' side of the HLA region. Kissmeyer-Nielsen et al. (1972) reviewed the genetics of HLA, including the close linkage of 'LA' and 'FOUR' and the linkage of HLA to other loci. An immune response locus (146880) is thought to be closely linked to the HLA locus or part of the HLA region. Studies of HLA antigens solubilized from cell membranes indicate that the products of the 2 loci reside on different molecules, and no firm association or bond between the 2 molecular products exists in the cell membrane. Solheim et al. (1973) presented evidence for a third segregant HLA series, the 'AJ' series. AJ appears to be between LA and 'FOUR' but closer to 'FOUR.' Weitkamp et al. (1973) showed that recombination between the LA and 'FOUR' loci was 50% greater in females than in males but age had no effect. </p><p>From the study of the primary structure of cross-reactive human histocompatibility antigens, Lopez de Castro et al. (1982) concluded that gene conversion may have played a role in the generation of HLA polymorphism. </p><p>Extended haplotypes in the MHC are evidenced by allelic association, better known as linkage disequilibrium, which is usually attributed to recent mutation of closely linked genes, founder effects, inbreeding, and so on. Due to crossover events, such effects are rapidly dissipated at chromosome map distances of 2 to 7 cM. The operation of crossover suppression was suggested by the findings of extended haplotypes that take in A1, at one end, and the GLO2 allele at the GLO1 locus, at the other end, and occur at frequencies significantly higher than expected (Awdeh et al., 1983). One of the haplotypes was found to be transmitted from males to 83% of their offspring. A possible mechanism for the maintenance of extended haplotypes is represented by possible human analogs of murine T mutants which are characterized by crossover suppression and male transmission bias. (According to Van Rood and Amos (1988), Ruggero Ceppellini introduced the term haplotype.) Dausset (1983) stated that he had probes that correlate with specific HLA haplotypes, e.g., the following Weissmann probes: EcoRV 8.6 kb with HLA-B8; EcoRV 4.6 kb with HLA-B35. He suggested the term genotope for a DNA fragment and the derivative terms allogenotope for a DNA fragment with polymorphism and isogenotope for one without polymorphism. Of course, polymorphism is probably usually present, even though not demonstrated with the restriction enzymes employed. </p>
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<strong>ALLELIC VARIANTS</strong>
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<strong>1 Selected Example):</strong>
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<strong>.0001 HYPERSENSITIVITY SYNDROME, CARBAMAZEPINE-INDUCED, SUSCEPTIBILITY TO</strong>
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HLA-A, HLA-A*3101
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SNP: rs1061235,
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gnomAD: rs1061235,
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ClinVar: RCV000022618
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<p>McCormack et al. (2011) performed a genomewide association study of samples obtained from 22 subjects with carbamazepine (CBZ)-induced hypersensitivity syndrome (HSS; see 608579), 43 subjects with CBZ-induced maculopapular exanthema (MPE), and 3,987 control subjects, all of European descent. They replicated the associations in samples from 145 subjects with CBZ-induced hypersensitivity reactions. The HLA-A*3101 allele, which has a prevalence of 2 to 5% in northern European populations, was significantly associated with HSS (p = 3.5 x 10(-8)). An independent genomewide association study of samples from subjects with MPE also showed an association with the HLA-A*3101 allele (p = 1.1 x 10(-6)). Follow-up genotyping confirmed the variant as a risk factor for HSS (OR, 12.41; 95 CI, 1.27-121.03), MPE (OR, 8.33; 95% CI, 3.59-19.36), and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS-TEN) (OR, 25.93; 95% CI, 4.93-116.18). The presence of the HLA-A*3101 allele was associated with CBZ-induced hypersensitivity reactions among subjects of northern European ancestry. The presence of the allele increased the risk from 5.0% to 26.0%, whereas its absence reduced the risk from 5.0% to 3.8%. </p><p>Among 18 Chinese patients, Hung et al. (2006) found a significant association between nonbullous adverse skin reactions induced by the drug carbamazepine and the HLA-A*3101 allele (p = 2.2 x 10(-3), OR of 17.5). The association was specific for maculopapular eruptions and not SJS (see 608579). </p><p>Among 42 Canadian children of diverse ancestries who experienced carbamazepine (CBZ)-induced hypersensitivity reactions and 91 CBZ-tolerant control children, Amstutz et al. (2013) found that HLA-A*3101 was significantly associated with CBZ-HSS (OR, 26.4; p = 0.0025) and MPE (OR, 8.6; p = 0.0037) but not with CBZ-SJS. </p>
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<strong>See Also:</strong>
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Adman and Pious (1970); Arnaiz-Villena and Festenstein (1976);
|
|
Auffray and Strominger (1986); Bailey (1971); Balner (1981); Bodmer
|
|
(1972); Bodmer et al. (1966); Bodmer (1978); Breuning et al. (1977);
|
|
Bull et al. (1978); Ceppellini and Van Rood (1974); Cohen et al.
|
|
(1983); Dausset et al. (1967); Dausset (1972); Dausset (1981);
|
|
Edwards et al. (1973); Engelfriet and Britten (1965); Erlich et al.
|
|
(1983); Fellous and Dausset (1970); Francke and Pellegrino (1977);
|
|
Gill et al. (1978); Gladstone et al. (1982); Goodfellow et al.
|
|
(1975); Helenius et al. (1978); Jordan et al. (1981);
|
|
Kissmeyer-Nielsen et al. (1969); Kissmeyer-Nielsen et al. (1968);
|
|
Lamm et al. (1975); Levine et al. (1985); Mayr and Mayr (1974); Orr
|
|
et al. (1982); Payne et al. (1964); Snell (1981); Thorsby et al.
|
|
(1970); Tiwari and Terasaki (1985); Uhr et al. (1979); Van Leeuwen et
|
|
al. (1964); Van Rood and Van Leeuwen (1963); Van Rood (1969); Van
|
|
Rood (1969); Van Someren et al. (1974); Walford et al. (1969); Wolski
|
|
et al. (1975)
|
|
</span>
|
|
<div>
|
|
<br />
|
|
</div>
|
|
</div>
|
|
|
|
|
|
|
|
|
|
<div>
|
|
<h4>
|
|
<span class="mim-font">
|
|
<strong>REFERENCES</strong>
|
|
</span>
|
|
</h4>
|
|
<div>
|
|
<p />
|
|
</div>
|
|
|
|
<div>
|
|
<ol>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Abderrahim, H., Sambucy, J.-L., Iris, F., Ougen, P., Billault, A., Chumakov, I. M., Dausset, J., Cohen, D., Le Paslier, D.
|
|
<strong>Cloning the human major histocompatibility complex in YACs.</strong>
|
|
Genomics 23: 520-527, 1994.
|
|
|
|
|
|
[PubMed: 7851878]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1006/geno.1994.1538]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Adman, R., Pious, D. A.
|
|
<strong>Isoantigenic variants: isolation from human diploid cells in culture.</strong>
|
|
Science 168: 370-372, 1970.
|
|
|
|
|
|
[PubMed: 5461672]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.168.3929.370]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Amstutz, U., Ross, C. J. D., Castro-Pastrana, L. I., Rieder, M. J., Shear, N. H., Hayden, M. R., Carleton, B. C., the CPNDS Consortium.
|
|
<strong>HLA-A*31:01 and HLA-B*15:02 as genetic markers for carbamazepine hypersensitivity in children.</strong>
|
|
Clin. Pharm. Ther. 94: 142-149, 2013.
|
|
|
|
|
|
[PubMed: 23588310]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/clpt.2013.55]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Arnaiz-Villena, A., Festenstein, H.
|
|
<strong>HLA genotyping by using spermatozoa: evidence for haploid gene expression.</strong>
|
|
Lancet 308: 707-709, 1976. Note: Originally Volume II.
|
|
|
|
|
|
[PubMed: 61393]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/s0140-6736(76)90005-2]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Auffray, C., Strominger, J. L.
|
|
<strong>Molecular genetics of the human major histocompatibility complex.</strong>
|
|
Adv. Hum. Genet. 15: 197-247, 1986.
|
|
|
|
|
|
[PubMed: 3513484]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1007/978-1-4615-8356-1_4]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Awdeh, Z. L., Raum, D., Yunis, E. J., Alper, C. A.
|
|
<strong>Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man.</strong>
|
|
Proc. Nat. Acad. Sci. 80: 259-263, 1983.
|
|
|
|
|
|
[PubMed: 6401863]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.80.1.259]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bach, F. H., Amos, D. B.
|
|
<strong>Hu-1 major histocompatibility locus in man.</strong>
|
|
Science 156: 1506-1508, 1967.
|
|
|
|
|
|
[PubMed: 4887739]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.156.3781.1506]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bach, M. L., Bach, F. H.
|
|
<strong>The genetics of histocompatibility.</strong>
|
|
Hosp. Practice 5(8): 33-44, 1970.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bailey, D. W.
|
|
<strong>Recombinant inbred strains: an aid to finding identity, linkage, and function of histocompatibility and other genes.</strong>
|
|
Transplantation 1 1: 325-327, 1971.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bakker, E., Pearson, P. L., Meera Khan, P., Schreuder, G. M. T., Madan, K.
|
|
<strong>Orientation of major histocompatibility (MHC) genes relative to the centromere of human chromosome 6.</strong>
|
|
Clin. Genet. 15: 198-202, 1979.
|
|
|
|
|
|
[PubMed: 761421]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1399-0004.1979.tb01762.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Balner, H., D'Amaro, J., Visser, T. P.
|
|
<strong>Tissue typing of chimpanzees: I. Evidence for two allelic series of leukocyte antigens.</strong>
|
|
Transplant. Proc. 6: 141-149, 1974.
|
|
|
|
|
|
[PubMed: 4831531]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Balner, H.
|
|
<strong>The major histocompatibility complex of primates: evolutionary aspects and comparative histogenetics.</strong>
|
|
Phil. Trans. Roy. Soc. London B Biol. Sci. 292: 109-119, 1981.
|
|
|
|
|
|
[PubMed: 6115401]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1098/rstb.1981.0019]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Berger, R., Bernheim, A., Sasportes, M., Hauptmann, G., Hors, J., Legrand, L., Fellous, M.
|
|
<strong>Regional mapping of the HLA on the short arm of chromosome 6.</strong>
|
|
Clin. Genet. 15: 245-251, 1979.
|
|
|
|
|
|
[PubMed: 84721]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1399-0004.1979.tb00975.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bernard, J.
|
|
<strong>La decouverte du systeme principal d'histocompatibilite de l'homme. (Editorial)</strong>
|
|
Presse Med. 75: 2369 only, 1967.
|
|
|
|
|
|
[PubMed: 6060307]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F. (ed.).
|
|
<strong>Evolutionary significance of the HL-A system.</strong>
|
|
Nature 237: 139-145, 1972.
|
|
|
|
|
|
[PubMed: 4113158]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/237139a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F., Bodmer, J. G., Adler, S., Payne, R., Bialek, J.
|
|
<strong>Genetics of '4' and 'LA' human leukocyte groups.</strong>
|
|
Ann. N.Y. Acad. Sci. 129: 473-489, 1966.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F., Bodmer, J. G., Tripp, M.
|
|
<strong>Recombination between the LA and 4 loci of the HL-A system. In: Histocompatibility Testing 1970.</strong>
|
|
Copenhagen: Munksgaard 1970. Pp. 187-191.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F.
|
|
<strong>The HLA System (17 papers).</strong>
|
|
Brit. Med. Bull. 34: 213-316, 1978.
|
|
|
|
|
|
[PubMed: 719335]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1093/oxfordjournals.bmb.a071500]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bodmer, W. F.
|
|
<strong>Personal Communication.</strong>
|
|
London, England 9/26/1986.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Borgaonkar, D. S., Bias, W. B., Chase, G. A., Sadasivan, G., Herr, H. M., Golomb, H. M., Bahr, G. F., Kunkel, L. M.
|
|
<strong>Identification of C6-G21 translocation chromosome by the Q-M and Giemsa banding techniques in a patient with Down's syndrome, with possible assignment of Gm locus.</strong>
|
|
Clin. Genet. 4: 53-57, 1973.
|
|
|
|
|
|
[PubMed: 4120631]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1399-0004.1973.tb01122.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Borgaonkar, D. S., Bias, W. B.
|
|
<strong>HL-A loci and chromosome 6.</strong>
|
|
Birth Defects Orig. Art. Ser. X(3): 67-68, 1974.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Breuning, M. H., van den Berg-Loonen, E. M., Bernini, L. F., Bijlsma, J. B., van Loghem, E., Meera Khan, P., Nijenhuis, L. E.
|
|
<strong>Localization of HLA on the short arm of chromosome 6.</strong>
|
|
Hum. Genet. 37: 131-139, 1977.
|
|
|
|
|
|
[PubMed: 885534]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1007/BF00393575]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Bull, R. W., Benson, J. W., Pearson, G., Mann, J. D.
|
|
<strong>HLA substantiation of a trisomic human chromosome 6.</strong>
|
|
Transplant. Proc. 10: 747-748, 1978.
|
|
|
|
|
|
[PubMed: 734744]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Cadwell, K., Coscoy, L.
|
|
<strong>Ubiquitination on nonlysine residues by a viral E3 ubiquitin ligase.</strong>
|
|
Science 309: 127-130, 2005. Note: Erratum: Science 311: 177 only, 2006.
|
|
|
|
|
|
[PubMed: 15994556]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.1110340]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Campbell, R. D., Trowsdale, J.
|
|
<strong>Map of the human MHC.</strong>
|
|
Immun. Today 14: 349-352, 1993.
|
|
|
|
|
|
[PubMed: 8363724]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0167-5699(93)90234-C]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Cardoso, C. S., Alves, H., Mascarenhas, M., Goncalves, R., Oliveira, P., Rodrigues, P., Cruz, E., de Sousa, M., Porto, G.
|
|
<strong>Co-selection of the H63D mutation and the HLA-A29 allele: a new paradigm of linkage disequilibrium?</strong>
|
|
Immunogenetics 53: 1002-1008, 2002.
|
|
|
|
|
|
[PubMed: 11904676]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1007/s00251-001-0414-8]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Carrington, M., Nelson, G. W., Martin, M. P., Kissner, T., Vlahov, D., Goedert, J. J., Kaslow, R., Buchbinder, S., Hoots, K., O'Brien, S. J.
|
|
<strong>HLA and HIV-1: heterozygote advantage and B*35-Cw*04 disadvantage.</strong>
|
|
Science 283: 1748-1752, 1999.
|
|
|
|
|
|
[PubMed: 10073943]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.283.5408.1748]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Ceppellini, R., Van Rood, J. J.
|
|
<strong>The HL-A system. I. Genetics and molecular biology.</strong>
|
|
Semin. Hemat. 11: 233-252, 1974.
|
|
|
|
|
|
[PubMed: 4151844]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Cohen, D., Paul, P., Font, M.-P., Cohen, O., Sayagh, B., Marcadet, A., Busson, M., Mahouy, G., Cann, H. M., Dausset, J.
|
|
<strong>Analysis of HLA class I genes with restriction endonuclease fragments: implications for polymorphism of the human major histocompatibility complex.</strong>
|
|
Proc. Nat. Acad. Sci. 80: 6289-6292, 1983.
|
|
|
|
|
|
[PubMed: 6312451]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.80.20.6289]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Colombani, J.
|
|
<strong>Changing the name of the major histocompatibility complex.</strong>
|
|
Res. Immun. 143: 411-417, 1992.
|
|
|
|
|
|
[PubMed: 1518955]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/s0923-2494(05)80073-2]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Danchin, E. G. J., Abi-Rached, L., Gilles, A., Pontarotti, P.
|
|
<strong>Conservation of the MHC-like region throughout evolution.</strong>
|
|
Immunogenetics 55: 141-148, 2003.
|
|
|
|
|
|
[PubMed: 12734695]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1007/s00251-003-0562-0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Dausset, J., Ivanyi, P., Colombani, J., Feingold, N., Legrand, L.
|
|
<strong>Le systeme Hu-1: etudes genetiques de population et de familles.</strong>
|
|
Nouv. Rev. Franc. Hemat. 7: 897-899, 1967.
|
|
|
|
|
|
[PubMed: 4230384]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Dausset, J.
|
|
<strong>Similarities between the HL-A system and other immunogenetic systems. (Editorial)</strong>
|
|
Vox Sang. 23: 153-164, 1972.
|
|
|
|
|
|
[PubMed: 4116477]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1423-0410.1972.tb03997.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Dausset, J.
|
|
<strong>The major histocompatibility complex in man: past, present, and future concepts.</strong>
|
|
Science 213: 1469-1474, 1981.
|
|
|
|
|
|
[PubMed: 6792704]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.6792704]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Dausset, J.
|
|
<strong>Personal Communication.</strong>
|
|
Paris, France 1/12/1983.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
de Groot, N. G., Otting, N., Doxiadis, G. G. M., Balla-Jhagjhoorsingh, S. S., Heeney, J. L., van Rood, J. J., Gagneux, P., Bontrop, R. E.
|
|
<strong>Evidence for an ancient selective sweep in the MHC class I gene repertoire of chimpanzees.</strong>
|
|
Proc. Nat. Acad. Sci. 99: 11748-11753, 2002.
|
|
|
|
|
|
[PubMed: 12186979]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.182420799]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Dorf, M. E., Balner, H., DeGroot, M. L., Benacerraf, B.
|
|
<strong>Histocompatibility-linked immune-response genes in the Rhesus monkey.</strong>
|
|
Transplant. Proc. 6: 119-124, 1974.
|
|
|
|
|
|
[PubMed: 4208749]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Edwards, J. H., Allen, F. H., Glenn, K. P., Lamm, L. U., Robson, E. B.
|
|
<strong>The linkage relationships of HL-A. In: Histocompatibility Testing.</strong>
|
|
Baltimore: Williams and Wilkins 1973.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Engelfriet, C. P., Britten, A.
|
|
<strong>The cytotoxic test for leucocyte antibodies. A simple and reliable technique.</strong>
|
|
Vox Sang. 10: 660-674, 1965.
|
|
|
|
|
|
[PubMed: 4955436]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1423-0410.1965.tb05178.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Erlich, H. A., Stetler, D., Sheng-Dong, R., Ness, D., Grumet, C.
|
|
<strong>Segregation and mapping analysis of polymorphic HLA class I restriction fragments: detection of a novel fragment.</strong>
|
|
Science 222: 72-74, 1983.
|
|
|
|
|
|
[PubMed: 6312559]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.6312559]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Fellous, M., Dausset, J.
|
|
<strong>Probable haploid expression of HL-A antigens on human spermatozoon.</strong>
|
|
Nature 225: 191-193, 1970.
|
|
|
|
|
|
[PubMed: 5409969]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/225191a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Figueroa, F., Gunther, E., Klein, J.
|
|
<strong>MHC polymorphism pre-dating speciation. (Letter)</strong>
|
|
Nature 335: 265-267, 1988.
|
|
|
|
|
|
[PubMed: 3137477]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/335265a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Francke, U., Pellegrino, M. A.
|
|
<strong>Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.</strong>
|
|
Proc. Nat. Acad. Sci. 74: 5776 only, 1977.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Francke, U., Pellegrino, M. A.
|
|
<strong>Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6.</strong>
|
|
Proc. Nat. Acad. Sci. 74: 1147-1151, 1977.
|
|
|
|
|
|
[PubMed: 265561]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.74.3.1147]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Gill, T. J., III, Cramer, D. V., Kunz, H. W.
|
|
<strong>The major histocompatibility complex--comparison in the mouse, man, and the rat: a review.</strong>
|
|
Am. J. Path. 90: 735-777, 1978.
|
|
|
|
|
|
[PubMed: 24344]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Gladstone, P., Fueresz, L., Pious, D.
|
|
<strong>Gene dosage and gene expression in the HLA region: evidence from deletion variants.</strong>
|
|
Proc. Nat. Acad. Sci. 79: 1235-1239, 1982.
|
|
|
|
|
|
[PubMed: 6951171]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.79.4.1235]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Gluecksohn-Waelsch, S., Erickson, R. P.
|
|
<strong>The T-locus of the mouse: implications for mechanisms of development.</strong>
|
|
Curr. Top. Dev. Biol. 5: 281-316, 1970.
|
|
|
|
|
|
[PubMed: 4120274]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/s0070-2153(08)60058-7]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Goodfellow, P. N., Jones, E., Van Heyningen, V., Solomon, E., Kennett, R., Bobrow, M., Bodmer, W. F.
|
|
<strong>Linkage relationships of the HL-A system and beta-2-microglobulin.</strong>
|
|
Birth Defects Orig. Art. Ser. 11(3): 162-167, 1975. Note: Alternate: Cytogenet. Cell Genet. 14: 332-337, 1975.
|
|
|
|
|
|
[PubMed: 54197]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Gruen, J. R., Nalabolu, S. R., Chu, T. W., Bowlus, C., Fan, W. F., Goei, V. L., Wei, H., Sivakamasundari, R., Liu, Y.-C., Xu, H. X., Parimoo, S., Nallur, G., Ajioka, R., Shukla, H., Bray-Ward, P., Pan, J., Weissman, S. M.
|
|
<strong>A transcription map of the major histocompatibility complex (MHC) class I region.</strong>
|
|
Genomics 36: 70-85, 1996.
|
|
|
|
|
|
[PubMed: 8812418]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1006/geno.1996.0427]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Habegger de Sorrentino, A., Sinchi, J. L., Marinic, K., Lopez, R., Iliovich, E.
|
|
<strong>KIR-HLA-A and B alleles of the Bw4 epitope against HIV infection in discordant heterosexual couples in Chaco Argentina.</strong>
|
|
Immunology 140: 273-279, 2013.
|
|
|
|
|
|
[PubMed: 23789883]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/imm.12137]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Hedrick, S. M.
|
|
<strong>Dawn of the hunt for nonclassical MHC function.</strong>
|
|
Cell 70: 177-180, 1992.
|
|
|
|
|
|
[PubMed: 1322246]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0092-8674(92)90092-q]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Helenius, A., Morein, B., Fries, E., Simons, K., Robinson, P., Schirrmacher, V., Terhorst, C., Strominger, J. L.
|
|
<strong>Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus.</strong>
|
|
Proc. Nat. Acad. Sci. 75: 3846-3850, 1978.
|
|
|
|
|
|
[PubMed: 278998]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.75.8.3846]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Hirai, M., Takahashi, E., Ishida, T., Hori, T.
|
|
<strong>Chromosomal localization of the major histocompatibility complex (MHC) in the rhesus monkey and chimpanzee by fluorescence in situ hybridization.</strong>
|
|
Cytogenet. Cell Genet. 57: 204-205, 1991.
|
|
|
|
|
|
[PubMed: 1743075]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1159/000133147]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Hood, L., Steinmetz, M., Goodenow, R.
|
|
<strong>Genes of the major histocompatibility complex.</strong>
|
|
Cell 28: 685-687, 1982.
|
|
|
|
|
|
[PubMed: 6284368]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0092-8674(82)90046-0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Hung, S.-I., Chung, W.-H., Jee, S.-H., Chen, W.-C., Chang, Y.-T., Lee, W.-R., Hu, S.-L., Wu, M.-T., Chen, G.-S., Wong, T.-W., Hsiao, P.-F., Chen, W.-H., Shih, H.-Y., Fang, W.-H., Wei, C.-Y., Lou, Y.-H., Huang, Y.-L., Lin, J.-J., Chen, Y.-T.
|
|
<strong>Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions.</strong>
|
|
Pharmacogenet. Genomics 16: 297-306, 2006.
|
|
|
|
|
|
[PubMed: 16538176]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1097/01.fpc.0000199500.46842.4a]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control Consortium 2.
|
|
<strong>Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.</strong>
|
|
Nature 476: 214-219, 2011.
|
|
|
|
|
|
[PubMed: 21833088]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/nature10251]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Jordan, B. R., Bregegere, F., Kourilsky, P.
|
|
<strong>Human HLA gene segment isolated by hybridization with mouse H-2 cDNA probes.</strong>
|
|
Nature 290: 521-523, 1981.
|
|
|
|
|
|
[PubMed: 6452579]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/290521a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Jorgensen, F., Lamm, L. U.
|
|
<strong>The HL-A system in clinical medicine.</strong>
|
|
Johns Hopkins Med. J. 131: 385-400, 1972.
|
|
|
|
|
|
[PubMed: 4117674]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Svejgaard, A., Ahrons, S., Nielsen, L. S.
|
|
<strong>Crossing-over within the HL-A system.</strong>
|
|
Nature 224: 75-76, 1969.
|
|
|
|
|
|
[PubMed: 5822911]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/224075a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Svejgaard, A., Hauge, M.
|
|
<strong>Genetics of the human HL-A transplantation system.</strong>
|
|
Nature 219: 1116-1119, 1968.
|
|
|
|
|
|
[PubMed: 5675623]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/2191116a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Kissmeyer-Nielsen, F., Thorsby, E.
|
|
<strong>Human transplantation antigens.</strong>
|
|
Transplant. Rev. 4: 1-176, 1970.
|
|
|
|
|
|
[PubMed: 4110124]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Klein, J., Figueroa, F.
|
|
<strong>Evolution of the major histocompatibility complex.</strong>
|
|
CRC Crit. Rev. Immun. 6: 295-386, 1986.
|
|
|
|
|
|
[PubMed: 3536303]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Klein, J.
|
|
<strong>The major histocompatibility complex of the mouse.</strong>
|
|
Science 203: 516-521, 1979.
|
|
|
|
|
|
[PubMed: 104386]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.104386]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Kompf, J., Bissbort, S., Gohler, F., Schunter, F., Wernet, P.
|
|
<strong>Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM. I. Recombination frequencies.</strong>
|
|
Hum. Genet. 44: 313-319, 1978.
|
|
|
|
|
|
[PubMed: 730169]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1007/BF00394296]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Friedrich, U., Petersen, G. B., Jorgensen, J., Nielsen, J., Therkelsen, A. J., Kissmeyer-Nielsen, F.
|
|
<strong>Assignment of the major histocompatibility complex to chromosome no. 6 in a family with a pericentric inversion.</strong>
|
|
Hum. Hered. 24: 273-284, 1974.
|
|
|
|
|
|
[PubMed: 4435793]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1159/000152660]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Kissmeyer-Nielsen, F., Svejgaard, A., Petersen, G. B., Thorsby, E., Mayr, W., Hogman, C.
|
|
<strong>On the orientation of the HL-A region and the PGM(3) locus in the chromosome.</strong>
|
|
Tissue Antigens 2: 205-214, 1972.
|
|
|
|
|
|
[PubMed: 4668408]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1399-0039.1972.tb00137.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Svejgaard, A., Kissmeyer-Nielsen, F.
|
|
<strong>Further evidence for PGM(3): HL-A is another linkage in man.</strong>
|
|
Nature N.B. 231: 109-110, 1971.
|
|
|
|
|
|
[PubMed: 5281183]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/newbio231109a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lamm, L. U., Thorsen, I.-L., Petersen, G. B., Jorgensen, J., Henningsen, K., Bech, B., Kissmeyer-Nielsen, F.
|
|
<strong>Data on the HL-A linkage group.</strong>
|
|
Ann. Hum. Genet. 38: 383-390, 1975.
|
|
|
|
|
|
[PubMed: 1190732]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1469-1809.1975.tb00628.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lawlor, D. A., Dickel, C. D., Hauswirth, W. W., Parham, P.
|
|
<strong>Ancient HLA genes from 7,500-year-old archaeological remains.</strong>
|
|
Nature 349: 785-788, 1991.
|
|
|
|
|
|
[PubMed: 2000147]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/349785a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lawlor, D. A., Ward, F. E., Ennis, P. D., Jackson, A. P., Parham, P.
|
|
<strong>HLA-A and B polymorphisms predate the divergence of humans and chimpanzees. (Letter)</strong>
|
|
Nature 335: 268-271, 1988.
|
|
|
|
|
|
[PubMed: 3412487]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/335268a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lawrance, S. K., Smith, C. L., Srivastava, R., Cantor, C. R., Weissman, S. M.
|
|
<strong>Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis.</strong>
|
|
Science 235: 1387-1390, 1987.
|
|
|
|
|
|
[PubMed: 3029868]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.3029868]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Leinders-Zufall, T., Brennan, P., Widmayer, P., Chandramani S., P., Maul-Pavicic, A., Jager, M., Li, X.-H., Breer, H., Zufall, F., Boehm, T.
|
|
<strong>MHC class I peptides as chemosensory signals in the vomeronasal organ.</strong>
|
|
Science 306: 1033-1037, 2004.
|
|
|
|
|
|
[PubMed: 15528444]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.1102818]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Levine, F., Erlich, H., Mach, B., Leach, R., White, R., Pious, D.
|
|
<strong>Deletion mapping of HLA and chromosome 6p genes.</strong>
|
|
Proc. Nat. Acad. Sci. 82: 3741-3745, 1985.
|
|
|
|
|
|
[PubMed: 2987942]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.82.11.3741]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lopez de Castro, J. A., Strominger, J. L., Strong, D. M., Orr, H. T.
|
|
<strong>Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.</strong>
|
|
Proc. Nat. Acad. Sci. 79: 3813-3817, 1982.
|
|
|
|
|
|
[PubMed: 6179086]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.79.12.3813]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Lutz, C. T.
|
|
<strong>Human leukocyte antigen Bw4 and Bw6 epitopes recognized by antibodies and natural killer cells.</strong>
|
|
Curr. Opin. Organ Transplant. 19: 436-441, 2014.
|
|
|
|
|
|
[PubMed: 24977435]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1097/MOT.0000000000000103]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
MacDonald, K. S., Fowke, K. R., Kimani, J., Dunand, V. A., Nagelkerke, N. J. D., Ball, T. B., Oyugi, J., Njagi, E., Gaur, L. K., Brunham, R. C., Wade, J., Luscher, M. A., Krausa, P., Rowland-Jones, S., Ngugi, E., Bwayo, J. J., Plummer, F. A.
|
|
<strong>Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.</strong>
|
|
J. Infect. Dis. 181: 1581-1589, 2000.
|
|
|
|
|
|
[PubMed: 10823757]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1086/315472]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Malissen, M., Malissen, B., Jordan, B. R.
|
|
<strong>Exon/intron organization and complete nucleotide sequence of an HLA gene.</strong>
|
|
Proc. Nat. Acad. Sci. 79: 893-897, 1982.
|
|
|
|
|
|
[PubMed: 6461010]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.79.3.893]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Mann, D. L., Rogentine, G. N., Jr., Fahey, J. L., Nathenson, S. G.
|
|
<strong>Molecular heterogeneity of human lymphoid (HL-A) alloantigens.</strong>
|
|
Science 163: 1460-1462, 1969.
|
|
|
|
|
|
[PubMed: 5773111]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.163.3874.1460]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Mayr, W. R., Mayr, D.
|
|
<strong>Analysis of the linkage between the HL-A loci and the genes of other markers.</strong>
|
|
Humangenetik 24: 129-133, 1974.
|
|
|
|
|
|
[PubMed: 4139102]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
McAulay, K. A., Higgins, C. D., Macsween, K. F., Lake, A., Jarrett, R. F., Robertson, F. L., Williams, H., Crawford, D. H.
|
|
<strong>HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection.</strong>
|
|
J. Clin. Invest. 117: 3042-3048, 2007.
|
|
|
|
|
|
[PubMed: 17909631]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1172/JCI32377]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
McCormack, M., Alfirevic, A., Bourgeois, S., Farrell, J. J., Kasperaviciute, D., Carrington, M., Sills, G. J., Marson, T., Jia, X., de Bakker, P. I. W., Chinthapalli, K., Molokhia, M., and 18 others.
|
|
<strong>HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.</strong>
|
|
New Eng. J. Med. 364: 1134-1143, 2011.
|
|
|
|
|
|
[PubMed: 21428769]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1056/NEJMoa1013297]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Messer, G., Zemmour, J., Orr, H. T., Parham, P., Weiss, E. H., Girdlestone, J.
|
|
<strong>HLA-J, a second inactivated class I HLA gene related to HLA-G and HLA-A.</strong>
|
|
J. Immun. 148: 4043-4053, 1992.
|
|
|
|
|
|
[PubMed: 1602142]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Morton, C. C., Kirsch, I. R., Nance, W. E., Evans, G. A., Korman, A. J., Strominger, J. L.
|
|
<strong>Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization.</strong>
|
|
Proc. Nat. Acad. Sci. 81: 2816-2820, 1984.
|
|
|
|
|
|
[PubMed: 6585830]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.81.9.2816]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Morton, N. E., Rao, D. C., Lindsten, J., Hulten, M., Yee, S.
|
|
<strong>A chiasma map of man.</strong>
|
|
Hum. Hered. 27: 38-51, 1977.
|
|
|
|
|
|
[PubMed: 844885]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1159/000152850]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Mulley, J. C., Hay, J., Sheffield, L. J., Sutherland, G. R.
|
|
<strong>Regional localization for HLA by recombination with a fragile site at 6p23.</strong>
|
|
Am. J. Hum. Genet. 35: 1284-1288, 1983.
|
|
|
|
|
|
[PubMed: 6650505]
|
|
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Neijssen, J., Herberts, C., Drijfhout, J. W., Reits, E., Janssen, L., Neefjes, J.
|
|
<strong>Cross-presentation by intercellular peptide transfer through gap junctions.</strong>
|
|
Nature 434: 83-88, 2005.
|
|
|
|
|
|
[PubMed: 15744304]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/nature03290]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Nejentsev, S., Howson, J. M. M., Walker, N. M., Szesko, J., Field, S. F., Stevens, H. E., Reynolds, P., Hardy, M., King, E., Masters, J., Hulme, J., Maier, L. M., and 8 others.
|
|
<strong>Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.</strong>
|
|
Nature 450: 887-892, 2007.
|
|
|
|
|
|
[PubMed: 18004301]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/nature06406]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Newell, W. R., Trowsdale, J., Beck, S.
|
|
<strong>MHCDB--database of the human MHC.</strong>
|
|
Immunogenetics 40: 109-115, 1994.
|
|
|
|
|
|
[PubMed: 8026859]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1007/BF00188173]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Orr, H. T., Bach, F. H., Ploegh, H. L., Strominger, J. L., Kavathas, P., DeMars, R.
|
|
<strong>Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex.</strong>
|
|
Nature 296: 454-456, 1982.
|
|
|
|
|
|
[PubMed: 7063041]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/296454a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Parham, P., Norman, P. J., Abi-Rached, L., Guethlein, L. A.
|
|
<strong>Human-specific evolution of killer cell immunoglobulin-like receptor recognition of major histocompatibility complex class I molecules.</strong>
|
|
Phil. Trans. Roy. Soc. London B Biol. Sci. 367: 800-811, 2012.
|
|
|
|
|
|
[PubMed: 22312047]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1098/rstb.2011.0266]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Patel, R., Mickey, M. R., Terasaki, P. I.
|
|
<strong>Serotyping for homotransplantation of kidneys from unrelated donors.</strong>
|
|
New Eng. J. Med. 279: 501-506, 1968.
|
|
|
|
|
|
[PubMed: 4876470]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1056/NEJM196809052791001]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Payne, R., Tripp, M., Weigle, J., Bodmer, W. F., Bodmer, J. G.
|
|
<strong>A new leukocyte isoantigen system in man.</strong>
|
|
Cold Spring Harbor Symp. Quant. Biol. 29: 285-295, 1964.
|
|
|
|
|
|
[PubMed: 14278475]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1101/sqb.1964.029.01.031]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Polacek, L. A., Phillips, R. B., Hackbarth, S. A., Duquesnoy, R. J.
|
|
<strong>A linkage study of the HLA region using C-band heteromorphisms.</strong>
|
|
Clin. Genet. 23: 177-185, 1983.
|
|
|
|
|
|
[PubMed: 6851213]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1399-0004.1983.tb01869.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Ragoussis, J., Bloemer, K., Pohla, H., Messer, G., Weiss, E. H., Ziegler, A.
|
|
<strong>A physical map including a new class I gene (cda12) of the human major histocompatibility complex (A2/B13 haplotype) derived from a monosomy 6 mutant cell line.</strong>
|
|
Genomics 4: 301-308, 1989.
|
|
|
|
|
|
[PubMed: 2497062]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0888-7543(89)90334-0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Ragoussis, J., van der Bliek, A., Trowsdale, J., Ziegler, A.
|
|
<strong>Mapping of HLA genes using pulsed field gradient electrophoreses.</strong>
|
|
FEBS Lett. 204: 1-4, 1986.
|
|
|
|
|
|
[PubMed: 3743756]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0014-5793(86)81376-x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, MP., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., and 14 others.
|
|
<strong>Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells.</strong>
|
|
Science 359: 86-90, 2018. Note: Erratum: Science 365 (6452) 2019.
|
|
|
|
|
|
[PubMed: 29302013]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.aam8825]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Salter, R. D., Norment, A. M., Chen, B. P., Clayberger, C., Krensky, A. M., Littman, D. R., Parham, P.
|
|
<strong>Polymorphism in the alpha(3) domain of HLA-A molecules affects binding to CD8.</strong>
|
|
Nature 338: 345-347, 1989.
|
|
|
|
|
|
[PubMed: 2784196]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/338345a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Schunter, F., Wernet, P., Kompf, J., Bissbort, S., Gohler, F.
|
|
<strong>Mapping of the linkage group GLO-Bf-HLA-B, C, A-PGM. II. Segregation analysis.</strong>
|
|
Hum. Genet. 44: 321-331, 1978.
|
|
|
|
|
|
[PubMed: 730170]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1007/BF00394297]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Shiina, T., Hosomichi, K., Inoko, H., Kulski, J. K.
|
|
<strong>The HLA genomic loci map: expression, interaction, diversity and disease.</strong>
|
|
J. Hum. Genet. 54: 15-39, 2009.
|
|
|
|
|
|
[PubMed: 19158813]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/jhg.2008.5]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Shivdasani, R. A., Haluska, F. G., Dock, N. L., Dover, J. S., Kineke, E. J., Anderson, K. C.
|
|
<strong>Graft-versus-host disease associated with transfusion of blood from unrelated HLA-homozygous donors.</strong>
|
|
New Eng. J. Med. 328: 766-770, 1993.
|
|
|
|
|
|
[PubMed: 8437597]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1056/NEJM199303183281105]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Shukla, H., Gillespie, G. A., Srivastava, R., Collins, F., Chorney, M. J.
|
|
<strong>A class I jumping clone places the HLA-G gene approximately 100 kilobases from HLA-H within the HLA-A subregion of the human MHC.</strong>
|
|
Genomics 10: 905-914, 1991.
|
|
|
|
|
|
[PubMed: 1916822]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0888-7543(91)90178-h]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Snell, G. D.
|
|
<strong>Studies in histocompatibility.</strong>
|
|
Science 213: 172-178, 1981.
|
|
|
|
|
|
[PubMed: 7017931]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.7017931]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Solheim, B. G., Bratlie, A., Sandberg, L., Staub-Nielsen, L., Thorsby, E.
|
|
<strong>Further evidence of a third HL-A locus.</strong>
|
|
Tissue Antigens 3: 439-453, 1973.
|
|
|
|
|
|
[PubMed: 4130127]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1399-0039.1973.tb00514.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Strachan, T.
|
|
<strong>Molecular genetics and polymorphism of class I HLA antigens.</strong>
|
|
Brit. Med. Bull. 43: 1-14, 1987.
|
|
|
|
|
|
[PubMed: 3315094]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1093/oxfordjournals.bmb.a072166]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Szpak, Y., Vieville, J.-C., Tabary, T., Naud, M.-C., Chopin, M., Edelson, C., Cohen, J. H. M., Dausset, J., de Kozak, Y., Pla, M.
|
|
<strong>Spontaneous retinopathy in HLA-A29 transgenic mice.</strong>
|
|
Proc. Nat. Acad. Sci. 98: 2572-2576, 2001.
|
|
|
|
|
|
[PubMed: 11226280]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.051595998]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Teshima, T., Ordemann, R., Reddy, P., Gagin, S., Liu, C., Cooke, K. R., Ferrara, J. L. M.
|
|
<strong>Acute graft-versus-host disease does not require alloantigen expression on host epithelium.</strong>
|
|
Nature Med. 8: 575-581, 2002. Note: Erratum: Nature Med. 8: 1039 only, 2002.
|
|
|
|
|
|
[PubMed: 12042807]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/nm0602-575]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Thorsby, E., Sandberg, L., Lindholm, A., Kissmeyer-Nielsen, F.
|
|
<strong>The HL-A system: evidence of a third sub-locus.</strong>
|
|
Scand. J. Haemat. 7: 195-200, 1970.
|
|
|
|
|
|
[PubMed: 5447964]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1600-0609.1970.tb01887.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Tiwari, J. L., Terasaki, P. I.
|
|
<strong>HLA and Disease Associations.</strong>
|
|
New York: Springer-Verlag (pub.) 1985.
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Tragardh, L., Rask, L., Wiman, K., Fohlman, J., Peterson, P. A.
|
|
<strong>Amino acid sequence of an immunoglobulin HLA antigen heavy chain domain.</strong>
|
|
Proc. Nat. Acad. Sci. 76: 5839-5842, 1979.
|
|
|
|
|
|
[PubMed: 118453]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.76.11.5839]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Trowsdale, J., Ragoussis, J., Campbell, R. D.
|
|
<strong>Map of the human MHC.</strong>
|
|
Immun. Today 12: 443-446, 1991.
|
|
|
|
|
|
[PubMed: 1786080]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0167-5699(91)90017-n]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Trowsdale, J.
|
|
<strong>Genetic and functional relationships between MHC and NK receptor genes.</strong>
|
|
Immunity 15: 363-374, 2001.
|
|
|
|
|
|
[PubMed: 11567627]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/s1074-7613(01)00197-2]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Ueta, M., Sotozono, C., Tokunaga, K., Yabe, T., Kinoshita, S.
|
|
<strong>Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese.</strong>
|
|
Am. J. Ophthal. 143: 367-368, 2007.
|
|
|
|
|
|
[PubMed: 17258541]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/j.ajo.2006.09.029]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Uhr, J. W., Capra, J. D., Vitetta, E. S., Cook, R. G.
|
|
<strong>Organization of the immune response genes.</strong>
|
|
Science 206: 292-297, 1979.
|
|
|
|
|
|
[PubMed: 113876]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.113876]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Van Leeuwen, A., Eernisse, J. G., Van Rood, J. J.
|
|
<strong>A new leucocyte group with two alleles: leucocyte group five.</strong>
|
|
Vox Sang. 9: 431-446, 1964.
|
|
|
|
|
|
[PubMed: 14177432]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1423-0410.1964.tb03311.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J., Amos, D. B.
|
|
<strong>In memoriam: Ruggero Ceppellini, 1917-1988.</strong>
|
|
Hum. Immun. 23: 1-3, 1988.
|
|
|
|
|
|
[PubMed: 3056890]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/0198-8859(88)90012-2]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J., Van Leeuwen, A.
|
|
<strong>Leukocyte grouping: a method and its application.</strong>
|
|
J. Clin. Invest. 42: 1382-1390, 1963.
|
|
|
|
|
|
[PubMed: 14060982]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1172/JCI104822]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J.
|
|
<strong>Leucocyte grouping and organ transplantation.</strong>
|
|
Brit. J. Haemat. 16: 211-220, 1969.
|
|
|
|
|
|
[PubMed: 5795218]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1111/j.1365-2141.1969.tb00396.x]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Van Rood, J. J.
|
|
<strong>Tissue typing and organ transplantation.</strong>
|
|
Lancet 293: 1142-1146, 1969. Note: Originally Volume I.
|
|
|
|
|
|
[PubMed: 4182701]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1016/s0140-6736(69)91659-6]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Van Someren, H., Westerveld, A., Hagemeijer, A., Mees, J. R., Meera Khan, P., Zaalberg, O. B.
|
|
<strong>Human antigen and enzyme markers in man-Chinese hamster somatic cell hybrids: evidence for synteny between the HL-A, PGM-3, ME-1, and IPO-B loci.</strong>
|
|
Proc. Nat. Acad. Sci. 71: 962-965, 1974.
|
|
|
|
|
|
[PubMed: 4362641]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1073/pnas.71.3.962]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Walford, R. L., Finkelstein, S., Hanna, C., Collins, Z.
|
|
<strong>Third sublocus in the HL-A human transplantation system.</strong>
|
|
Nature 224: 74-75, 1969.
|
|
|
|
|
|
[PubMed: 5822910]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1038/224074a0]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Weitkamp, L. R., Van Rood, J. J., Thorsby, E., Bias, W. B., Fotino, M., Lawler, S. D., Dausset, J., Mayr, W. R., Bodmer, J., Ward, F. S., Seignalet, J., Payne, R., Kissmeyer-Nielsen, F., Gatti, R. A., Sachs, J. A., Lamm, L. U.
|
|
<strong>The relation of parental sex and age to recombination in the HL-A system.</strong>
|
|
Hum. Hered. 23: 197-205, 1973.
|
|
|
|
|
|
[PubMed: 4760577]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1159/000152574]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Wolski, K. P., Schmid, F. R., Mittal, K. K.
|
|
<strong>Genetic linkage between the HL-A system and a deficit of the second component (C2) of complement.</strong>
|
|
Science 188: 1020-1022, 1975.
|
|
|
|
|
|
[PubMed: 1145185]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1126/science.1145185]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Zareparsi, S., James, D. M., Kaye, J. A., Bird, T. D., Schellenberg, G. D., Payami, H.
|
|
<strong>HLA-A2 homozygosity but not heterozygosity is associated with Alzheimer disease.</strong>
|
|
Neurology 58: 973-975, 2002.
|
|
|
|
|
|
[PubMed: 11914421]
|
|
|
|
|
|
[Full Text: https://doi.org/10.1212/wnl.58.6.973]
|
|
|
|
|
|
</p>
|
|
</li>
|
|
|
|
<li>
|
|
<p class="mim-text-font">
|
|
Ziegler, A., Ragoussis, J., Fonatsch, C., Weiss, E.
|
|
<strong>A physical map of the human major histocompatibility (HLA) complex derived from a monosomy 6 mutant cell line. (Abstract)</strong>
|
|
Cytogenet. Cell Genet. 51: 1116 only, 1989.
|
|
|
|
</p>
|
|
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|
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Ada Hamosh - updated : 08/14/2018<br>Paul J. Converse - updated : 3/19/2015<br>Marla J. F. O'Neill - updated : 6/30/2014<br>Ada Hamosh - updated : 8/24/2011<br>Ada Hamosh - updated : 6/7/2011<br>Carol A. Bocchini - updated : 5/21/2009<br>Ada Hamosh - updated : 4/24/2008<br>Paul J. Converse - updated : 2/5/2008<br>Jane Kelly - updated : 11/21/2007<br>Cassandra L. Kniffin - updated : 10/30/2007<br>Ada Hamosh - updated : 2/1/2006<br>Ada Hamosh - updated : 3/3/2005<br>Victor A. McKusick - updated : 9/22/2003<br>Cassandra L. Kniffin - updated : 12/9/2002<br>Victor A. McKusick - updated : 10/11/2002<br>Paul J. Converse - updated : 5/31/2002<br>Victor A. McKusick - updated : 5/23/2002<br>Paul J. Converse - updated : 4/30/2001<br>Victor A. McKusick - updated : 3/12/2001<br>Ada Hamosh - updated : 3/24/1999
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Victor A. McKusick : 6/4/1986
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