2214 lines
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Entry
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- #140700 - HEINZ BODY ANEMIAS
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- OMIM
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<p>
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<span class="h4">#140700</span>
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<br />
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<strong>Table of Contents</strong>
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<a href="#title"><strong>Title</strong></a>
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<li role="presentation">
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<a href="#phenotypeMap"><strong>Phenotype-Gene Relationships</strong></a>
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<li role="presentation">
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<a href="/clinicalSynopsis/140700"><strong>Clinical Synopsis</strong></a>
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<a href="#text"><strong>Text</strong></a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#description">Description</a>
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<a href="#clinicalFeatures">Clinical Features</a>
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<a href="#molecularGenetics">Molecular Genetics</a>
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<a href="#seeAlso"><strong>See Also</strong></a>
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<a href="#references"><strong>References</strong></a>
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<a href="#contributors"><strong>Contributors</strong></a>
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<a href="#creationDate"><strong>Creation Date</strong></a>
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<a href="#editHistory"><strong>Edit History</strong></a>
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<div style="display: table-cell;">External Links</div>
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</a>
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</h4>
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<div style="display: table-row">
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<div id="mimClinicalResourcesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">▼</div>
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<div style="display: table-cell;">Clinical Resources</div>
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<div><a href="https://clinicaltrials.gov/search?cond=(HEINZ BODY ANEMIAS) OR (HBB OR HBA2 OR HBA1)" class="mim-tip-hint" title="Clinical Trials" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Clinical Trials', 'domain': 'clinicaltrials.gov'})">Clinical Trials</a></div>
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<div><a href="https://www.diseaseinfosearch.org/x/3265" class="mim-tip-hint" title="Network of disease-specific advocacy organizations, universities, private companies, government agencies, and public policy organizations." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Genetic Alliance', 'domain': 'diseaseinfosearch.org'})">Genetic Alliance</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=140700[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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<span class="small">
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<a href="#mimAnimalModelsLinksFold" id="mimAnimalModelsLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimAnimalModelsLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Animal Models</div>
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</a>
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</span>
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.alliancegenome.org/disease/DOID:0111363" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
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<div><a href="http://www.informatics.jax.org/disease/140700" class="mim-tip-hint" title="Phenotypes, alleles, and disease models from Mouse Genome Informatics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Phenotype', 'domain': 'informatics.jax.org'})">MGI Mouse Phenotype</a></div>
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<div><a href="https://wormbase.org/resources/disease/DOID:0111363" class="mim-tip-hint" title="Database of the biology and genome of Caenorhabditis elegans and related nematodes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Wormbase Disease Ontology', 'domain': 'wormbase.org'})">Wormbase Disease Ontology</a></div>
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<span>
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<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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</span>
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<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
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<div>
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<a id="title" class="mim-anchor"></a>
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<div>
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<a id="number" class="mim-anchor"></a>
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<div class="text-right">
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<a href="#" class="mim-tip-icd" qtip_title="<strong>ICD+</strong>" qtip_text="
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<strong>DO:</strong> 0111363<br />
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">ICD+</a>
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<div>
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<span class="h3">
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<span class="mim-font mim-tip-hint" title="Phenotype description, molecular basis known">
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<span class="text-danger"><strong>#</strong></span>
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140700
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</span>
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</span>
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<div>
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<a id="preferredTitle" class="mim-anchor"></a>
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<h3>
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<span class="mim-font">
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HEINZ BODY ANEMIAS
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</h3>
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</div>
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<div>
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<br />
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</div>
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<a id="phenotypeMap" class="mim-anchor"></a>
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<h4>
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<span class="mim-font">
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<strong>Phenotype-Gene Relationships</strong>
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</span>
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</h4>
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<div>
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<table class="table table-bordered table-condensed table-hover small mim-table-padding">
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<thead>
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<tr class="active">
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<th>
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Location
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</th>
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<th>
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Phenotype
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</th>
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<th>
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Phenotype <br /> MIM number
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</th>
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<th>
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Inheritance
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</th>
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<th>
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Phenotype <br /> mapping key
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</th>
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<th>
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Gene/Locus
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</th>
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<th>
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Gene/Locus <br /> MIM number
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<tbody>
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<tr>
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<td>
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<span class="mim-font">
|
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<a href="/geneMap/11/110?start=-3&limit=10&highlight=110">
|
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11p15.4
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</a>
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</span>
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</td>
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<td>
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<span class="mim-font">
|
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Heinz body anemia
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/140700"> 140700 </a>
|
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
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HBB
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/141900"> 141900 </a>
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</span>
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</td>
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</tr>
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<tr>
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<td>
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<span class="mim-font">
|
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<a href="/geneMap/16/17?start=-3&limit=10&highlight=17">
|
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16p13.3
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</a>
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</span>
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</td>
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<td>
|
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<span class="mim-font">
|
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Heinz body anemia
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</span>
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</td>
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<td>
|
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<span class="mim-font">
|
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<a href="/entry/140700"> 140700 </a>
|
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
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HBA2
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/141850"> 141850 </a>
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</span>
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</td>
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</tr>
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<tr>
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<td>
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<span class="mim-font">
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<a href="/geneMap/16/18?start=-3&limit=10&highlight=18">
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16p13.3
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</a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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Heinz body anemias, alpha-
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</span>
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</td>
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<td>
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<span class="mim-font">
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<a href="/entry/140700"> 140700 </a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="Autosomal dominant">AD</abbr>
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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</span>
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HBA1
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<a href="/entry/141800"> 141800 </a>
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<span class="glyphicon glyphicon-question-sign mim-tip-hint" title="OMIM PheneGene graphics depict relationships between phenotypes, groups of related phenotypes (Phenotypic Series), and genes.<br /><a href='/static/omim/pdf/OMIM_Graphics.pdf' target='_blank'>A quick reference overview and guide (PDF)</a>"></span>
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- Nonspherocytic hemolytic anemia <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C4025735&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C4025735</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0001930" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0001930</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0001930" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0001930</a>]</span><br /> - Heinz bodies in erythrocytes after splenectomy<br />
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<strong> Inheritance </strong>
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- Autosomal dominant <span class="mim-feature-ids hidden">[SNOMEDCT: <a href="https://purl.bioontology.org/ontology/SNOMEDCT/263681008" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">263681008</a>, <a href="https://purl.bioontology.org/ontology/SNOMEDCT/771269000" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'SNOMEDCT\', \'domain\': \'bioontology.org\'})">771269000</a>]</span> <span class="mim-feature-ids hidden">[UMLS: <a href="https://bioportal.bioontology.org/search?q=C0443147&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C0443147</a>, <a href="https://bioportal.bioontology.org/search?q=C1867440&searchproperties=true" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'UMLS\', \'domain\': \'bioontology.org\'})">C1867440</a> HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000006" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000006</a>]</span> <span class="mim-feature-ids hidden">[HPO: <a href="https://hpo.jax.org/app/browse/term/HP:0000006" target="_blank" onclick="gtag(\'event\', \'mim_outbound\', {\'name\': \'HPO\', \'domain\': \'hpo.jax.org\'})">HP:0000006</a>]</span><br />
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<p>A number sign (#) is used with this entry because Heinz body anemia is observed with heterozygous mutations in either the alpha-globin (HBA1, <a href="/entry/141800">141800</a>; HBA2, <a href="/entry/141850">141850</a>) or the beta-globin (HBB; <a href="/entry/141900">141900</a>) genes.</p>
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<p>This is a form of nonspherocytic hemolytic anemia of Dacie type I (in vitro autohemolysis is not corrected by added glucose). After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability.</p><p>Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies; <a href="/entry/208530">208530</a>).</p>
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<p><a href="#4" class="mim-tip-reference" title="Rees, D. C., Rochette, J., Schofield, C., Green, B., Morris, M., Parker, N. E., Sasaki, H., Tanaka, A., Ohba, Y., Clegg, J. B. <strong>A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta-67(E11) val-met-to-asp).</strong> Blood 88: 341-348, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8704193/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8704193</a>]" pmid="8704193">Rees et al. (1996)</a> reinvestigated the patient who was the subject of the first description of idiopathic Heinz body anemia (<a href="#1" class="mim-tip-reference" title="Cathie, I. A. B. <strong>Apparent idiopathic Heinz body anaemia.</strong> Great Ormond Street J. 2: 43-48, 1952."None>Cathie, 1952</a>) and who was subsequently shown to have hemoglobin Bristol (<a href="/entry/141900#0030">141900.0030</a>). The patient was a 5-year-old boy with anemia from birth and no obvious precipitating toxic agents. The child was first seen at age 16 months, when he was jaundiced, with a hemoglobin of 7 g/dl, punctate basophilia, and 37% reticulocytes. A diagnosis of congenital achloruric jaundice was made and the spleen removed. He received blood transfusions regularly until he was 15, when they were stopped with no adverse effects. At the time of the report by <a href="#4" class="mim-tip-reference" title="Rees, D. C., Rochette, J., Schofield, C., Green, B., Morris, M., Parker, N. E., Sasaki, H., Tanaka, A., Ohba, Y., Clegg, J. B. <strong>A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta-67(E11) val-met-to-asp).</strong> Blood 88: 341-348, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8704193/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8704193</a>]" pmid="8704193">Rees et al. (1996)</a>, the patient was 47 years old and in good health. His steady-state hemoglobin was 7.5 g/dl. He had suffered one hemolytic crisis following food poisoning in 1991 but did not need a transfusion. He had 2 subarachnoid hemorrhages in his twenties, with no residual deficit. He had valvular heart disease following rheumatic fever at age 16. None of his relatives, including parents and 5 sibs, suffered from hemolysis or anemia. The 2 unrelated patients studied by <a href="#4" class="mim-tip-reference" title="Rees, D. C., Rochette, J., Schofield, C., Green, B., Morris, M., Parker, N. E., Sasaki, H., Tanaka, A., Ohba, Y., Clegg, J. B. <strong>A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta-67(E11) val-met-to-asp).</strong> Blood 88: 341-348, 1996.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8704193/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8704193</a>]" pmid="8704193">Rees et al. (1996)</a> were the Japanese patients of <a href="#3" class="mim-tip-reference" title="Ohba, Y., Matsuoka, M., Miyaji, T., Shibuya, T., Sakuragawa, M. <strong>Hemoglobin Bristol or beta 67 (E11) val-to-asp in Japan.</strong> Hemoglobin 9: 79-85, 1985.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3997544/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3997544</a>] [<a href="https://doi.org/10.3109/03630268508996986" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="3997544">Ohba et al. (1985)</a>. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=3997544+8704193" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>Specific defects of the beta-globin gene have been demonstrated as the basis of Heinz body anemia associated with Hb Bruxelles (<a href="/entry/141900#0033">141900.0033</a>), Hb Hammersmith (<a href="/entry/141900#0100">141900.0100</a>), Hb Indianapolis (<a href="/entry/141900#0117">141900.0117</a>), and Hb Tacoma (<a href="/entry/141900#0278">141900.0278</a>). In addition to severe Heinz body anemia, Hb St. Louis (<a href="/entry/141900#0268">141900.0268</a>) also causes methemoglobinemia.</p><p>Hb Toyama (<a href="/entry/141800#0152">141800.0152</a>) is an example of a Heinz body anemia due to mutation in the HBA1 gene.</p><p>Hb Bibba (<a href="/entry/141850#0030">141850.0030</a>) is an example of Heinz body anemia due to mutation in the HBA2 gene.</p>
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<a href="#Dacie1964" class="mim-tip-reference" title="Dacie, J. V., Grimes, A. J., Meisler, A., Steingold, L., Hemsted, E. H., Beaven, G. H., White, J. C. <strong>Hereditary Heinz-body anaemia: a report of studies on five patients with mild anaemia.</strong> Brit. J. Haemat. 10: 388-402, 1964.">Dacie et al. (1964)</a>
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<a id="Cathie1952" class="mim-anchor"></a>
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Cathie, I. A. B.
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<strong>Apparent idiopathic Heinz body anaemia.</strong>
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Great Ormond Street J. 2: 43-48, 1952.
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Dacie, J. V., Grimes, A. J., Meisler, A., Steingold, L., Hemsted, E. H., Beaven, G. H., White, J. C.
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<strong>Hereditary Heinz-body anaemia: a report of studies on five patients with mild anaemia.</strong>
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Brit. J. Haemat. 10: 388-402, 1964.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/14184033/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">14184033</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=14184033" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1111/j.1365-2141.1964.tb00715.x" target="_blank">Full Text</a>]
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Ohba, Y., Matsuoka, M., Miyaji, T., Shibuya, T., Sakuragawa, M.
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<strong>Hemoglobin Bristol or beta 67 (E11) val-to-asp in Japan.</strong>
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Hemoglobin 9: 79-85, 1985.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/3997544/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">3997544</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=3997544" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.3109/03630268508996986" target="_blank">Full Text</a>]
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Rees, D. C., Rochette, J., Schofield, C., Green, B., Morris, M., Parker, N. E., Sasaki, H., Tanaka, A., Ohba, Y., Clegg, J. B.
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<strong>A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta-67(E11) val-met-to-asp).</strong>
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Blood 88: 341-348, 1996.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/8704193/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">8704193</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=8704193" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Ada Hamosh - updated : 6/15/1999
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Creation Date:
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<span class="mim-text-font">
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Victor A. McKusick : 6/4/1986
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carol : 06/14/2018
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carol : 05/14/2018<br>carol : 08/12/2011<br>alopez : 4/19/2005<br>carol : 6/27/1999<br>carol : 6/27/1999<br>carol : 6/15/1999<br>mimadm : 9/24/1994<br>carol : 4/14/1992<br>supermim : 3/16/1992<br>carol : 1/17/1992<br>carol : 10/25/1991<br>carol : 10/21/1991
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<strong>#</strong> 140700
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HEINZ BODY ANEMIAS
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<strong>DO:</strong> 0111363;
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<strong>Phenotype-Gene Relationships</strong>
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Location
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Phenotype
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Phenotype <br /> MIM number
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Inheritance
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Phenotype <br /> mapping key
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Gene/Locus
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Gene/Locus <br /> MIM number
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11p15.4
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Heinz body anemia
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140700
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Autosomal dominant
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3
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HBB
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141900
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16p13.3
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Heinz body anemia
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140700
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Autosomal dominant
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3
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HBA2
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141850
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16p13.3
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Heinz body anemias, alpha-
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140700
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Autosomal dominant
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3
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HBA1
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141800
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<span class="mim-font">
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<strong>TEXT</strong>
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</h4>
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<span class="mim-text-font">
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<p>A number sign (#) is used with this entry because Heinz body anemia is observed with heterozygous mutations in either the alpha-globin (HBA1, 141800; HBA2, 141850) or the beta-globin (HBB; 141900) genes.</p>
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<span class="mim-font">
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<strong>Description</strong>
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<p>This is a form of nonspherocytic hemolytic anemia of Dacie type I (in vitro autohemolysis is not corrected by added glucose). After splenectomy, which has little benefit, basophilic inclusions called Heinz bodies are demonstrable in the erythrocytes. Before splenectomy, diffuse or punctate basophilia may be evident. Most of these cases are probably instances of hemoglobinopathy. The hemoglobin demonstrates heat lability.</p><p>Heinz bodies are observed also with the Ivemark syndrome (asplenia with cardiovascular anomalies; 208530).</p>
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<h4>
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<span class="mim-font">
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<strong>Clinical Features</strong>
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<p>Rees et al. (1996) reinvestigated the patient who was the subject of the first description of idiopathic Heinz body anemia (Cathie, 1952) and who was subsequently shown to have hemoglobin Bristol (141900.0030). The patient was a 5-year-old boy with anemia from birth and no obvious precipitating toxic agents. The child was first seen at age 16 months, when he was jaundiced, with a hemoglobin of 7 g/dl, punctate basophilia, and 37% reticulocytes. A diagnosis of congenital achloruric jaundice was made and the spleen removed. He received blood transfusions regularly until he was 15, when they were stopped with no adverse effects. At the time of the report by Rees et al. (1996), the patient was 47 years old and in good health. His steady-state hemoglobin was 7.5 g/dl. He had suffered one hemolytic crisis following food poisoning in 1991 but did not need a transfusion. He had 2 subarachnoid hemorrhages in his twenties, with no residual deficit. He had valvular heart disease following rheumatic fever at age 16. None of his relatives, including parents and 5 sibs, suffered from hemolysis or anemia. The 2 unrelated patients studied by Rees et al. (1996) were the Japanese patients of Ohba et al. (1985). </p>
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<h4>
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<span class="mim-font">
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<strong>Molecular Genetics</strong>
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</h4>
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<span class="mim-text-font">
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<p>Specific defects of the beta-globin gene have been demonstrated as the basis of Heinz body anemia associated with Hb Bruxelles (141900.0033), Hb Hammersmith (141900.0100), Hb Indianapolis (141900.0117), and Hb Tacoma (141900.0278). In addition to severe Heinz body anemia, Hb St. Louis (141900.0268) also causes methemoglobinemia.</p><p>Hb Toyama (141800.0152) is an example of a Heinz body anemia due to mutation in the HBA1 gene.</p><p>Hb Bibba (141850.0030) is an example of Heinz body anemia due to mutation in the HBA2 gene.</p>
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<div>
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<h4>
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<span class="mim-font">
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<strong>See Also:</strong>
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</span>
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</h4>
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<span class="mim-text-font">
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Dacie et al. (1964)
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<div>
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<br />
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<span class="mim-font">
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<strong>REFERENCES</strong>
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</span>
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</h4>
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<div>
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<p />
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<ol>
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<li>
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<p class="mim-text-font">
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Cathie, I. A. B.
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<strong>Apparent idiopathic Heinz body anaemia.</strong>
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Great Ormond Street J. 2: 43-48, 1952.
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</p>
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</li>
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<li>
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<p class="mim-text-font">
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Dacie, J. V., Grimes, A. J., Meisler, A., Steingold, L., Hemsted, E. H., Beaven, G. H., White, J. C.
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<strong>Hereditary Heinz-body anaemia: a report of studies on five patients with mild anaemia.</strong>
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Brit. J. Haemat. 10: 388-402, 1964.
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[PubMed: 14184033]
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[Full Text: https://doi.org/10.1111/j.1365-2141.1964.tb00715.x]
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</p>
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<li>
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<p class="mim-text-font">
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Ohba, Y., Matsuoka, M., Miyaji, T., Shibuya, T., Sakuragawa, M.
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<strong>Hemoglobin Bristol or beta 67 (E11) val-to-asp in Japan.</strong>
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Hemoglobin 9: 79-85, 1985.
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[PubMed: 3997544]
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[Full Text: https://doi.org/10.3109/03630268508996986]
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</p>
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<li>
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<p class="mim-text-font">
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Rees, D. C., Rochette, J., Schofield, C., Green, B., Morris, M., Parker, N. E., Sasaki, H., Tanaka, A., Ohba, Y., Clegg, J. B.
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<strong>A novel silent posttranslational mechanism converts methionine to aspartate in hemoglobin Bristol (beta-67(E11) val-met-to-asp).</strong>
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Blood 88: 341-348, 1996.
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[PubMed: 8704193]
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Contributors:
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</div>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Ada Hamosh - updated : 6/15/1999
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</span>
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</div>
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</div>
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</div>
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<div>
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Creation Date:
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</span>
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</div>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Victor A. McKusick : 6/4/1986
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<span class="text-nowrap mim-text-font">
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Edit History:
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</span>
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</div>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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carol : 06/14/2018<br>carol : 05/14/2018<br>carol : 08/12/2011<br>alopez : 4/19/2005<br>carol : 6/27/1999<br>carol : 6/27/1999<br>carol : 6/15/1999<br>mimadm : 9/24/1994<br>carol : 4/14/1992<br>supermim : 3/16/1992<br>carol : 1/17/1992<br>carol : 10/25/1991<br>carol : 10/21/1991
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