2431 lines
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Entry
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- *135620 - INTEGRIN, ALPHA-5; ITGA5
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- OMIM
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<p>
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<span class="h4">*135620</span>
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<br />
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<strong>Table of Contents</strong>
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</p>
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<nav>
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<li role="presentation">
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<a href="#title"><strong>Title</strong></a>
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<li role="presentation">
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<a href="#text"><strong>Text</strong></a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#cloning">Cloning and Expression</a>
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</li>
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<li role="presentation" style="margin-left: 1em">
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<a href="#geneFunction">Gene Function</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#mapping">Mapping</a>
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<li role="presentation" style="margin-left: 1em">
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<a href="#animalModel">Animal Model</a>
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<li role="presentation">
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<a href="#references"><strong>References</strong></a>
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<li role="presentation">
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<a href="#contributors"><strong>Contributors</strong></a>
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<a href="#creationDate"><strong>Creation Date</strong></a>
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</li>
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<li role="presentation">
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<a href="#editHistory"><strong>Edit History</strong></a>
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<div class="panel-heading mim-panel-heading" role="tab" id="mimExternalLinks">
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<h4 class="panel-title">
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<a href="#mimExternalLinksFold" id="mimExternalLinksToggle" class="mimTriangleToggle" role="button" data-toggle="collapse">
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<div style="display: table-row">
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<div id="mimExternalLinksToggleTriangle" class="small" style="color: white; display: table-cell;">▼</div>
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<div style="display: table-cell;">External Links</div>
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</div>
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</a>
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</h4>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimGenome">
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<span class="panel-title">
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<span class="small">
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<a href="#mimGenomeLinksFold" id="mimGenomeLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimGenomeLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Genome
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</a>
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</span>
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</span>
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</div>
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<div id="mimGenomeLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="genome">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000161638;t=ENST00000293379" class="mim-tip-hint" title="Genome databases for vertebrates and other eukaryotic species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/genome/gdv/browser/gene/?id=3678" class="mim-tip-hint" title="Detailed views of the complete genomes of selected organisms from vertebrates to protozoa." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Genome Viewer', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Genome Viewer</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=135620" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimDna">
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<span class="panel-title">
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<span class="small">
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<a href="#mimDnaLinksFold" id="mimDnaLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimDnaLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> DNA
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</a>
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</span>
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</span>
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</div>
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<div id="mimDnaLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ensembl.org/Homo_sapiens/Transcript/Sequence_cDNA?db=core;g=ENSG00000161638;t=ENST00000293379" class="mim-tip-hint" title="Transcript-based views for coding and noncoding DNA." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl (MANE Select)</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_002205,XM_024448970" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/nuccore/NM_002205" class="mim-tip-hint" title="A collection of genome, gene, and transcript sequence data from several sources, including GenBank, RefSeq." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI RefSeq (MANE)', 'domain': 'ncbi.nlm.nih'})">NCBI RefSeq (MANE Select)</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&hgFind=omimGeneAcc&position=135620" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">UCSC Genome Browser</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimProtein">
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<span class="panel-title">
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<span class="small">
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<a href="#mimProteinLinksFold" id="mimProteinLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
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<span id="mimProteinLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">►</span> Protein
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</a>
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</span>
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</span>
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</div>
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<div id="mimProteinLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://hprd.org/summary?hprd_id=00627&isoform_id=00627_1&isoform_name=Isoform_1" class="mim-tip-hint" title="The Human Protein Reference Database; manually extracted and visually depicted information on human proteins." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HPRD', 'domain': 'hprd.org'})">HPRD</a></div>
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<div><a href="https://www.proteinatlas.org/search/ITGA5" class="mim-tip-hint" title="The Human Protein Atlas contains information for a large majority of all human protein-coding genes regarding the expression and localization of the corresponding proteins based on both RNA and protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HumanProteinAtlas', 'domain': 'proteinatlas.org'})">Human Protein Atlas</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/protein/31438,182710,14250644,23831237,119617186,119617187,119617188,158256572,189065485,194388164,311643789,1017029567,1370461815,2462531751" class="mim-tip-hint" title="NCBI protein data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Protein', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Protein</a></div>
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<div><a href="https://www.uniprot.org/uniprotkb/P08648" class="mim-tip-hint" title="Comprehensive protein sequence and functional information, including supporting data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UniProt', 'domain': 'uniprot.org'})">UniProt</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimGeneInfo">
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<span class="panel-title">
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<span class="small">
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<a href="#mimGeneInfoLinksFold" id="mimGeneInfoLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimGeneInfoLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Gene Info</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimGeneInfoLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="http://biogps.org/#goto=genereport&id=3678" class="mim-tip-hint" title="The Gene Portal Hub; customizable portal of gene and protein function information." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'BioGPS', 'domain': 'biogps.org'})">BioGPS</a></div>
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<div><a href="https://www.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000161638;t=ENST00000293379" class="mim-tip-hint" title="Orthologs, paralogs, regulatory regions, and splice variants." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Ensembl', 'domain': 'ensembl.org'})">Ensembl</a></div>
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<div><a href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ITGA5" class="mim-tip-hint" title="The Human Genome Compendium; web-based cards integrating automatically mined information on human genes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneCards', 'domain': 'genecards.org'})">GeneCards</a></div>
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<div><a href="http://amigo.geneontology.org/amigo/search/annotation?q=ITGA5" class="mim-tip-hint" title="Terms, defined using controlled vocabulary, representing gene product properties (biologic process, cellular component, molecular function) across species." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GeneOntology', 'domain': 'amigo.geneontology.org'})">Gene Ontology</a></div>
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<div><a href="https://www.genome.jp/dbget-bin/www_bget?hsa+3678" class="mim-tip-hint" title="Kyoto Encyclopedia of Genes and Genomes; diagrams of signaling pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'KEGG', 'domain': 'genome.jp'})">KEGG</a></div>
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<dd><a href="http://v1.marrvel.org/search/gene/ITGA5" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></dd>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/3678" class="mim-tip-hint" title="Gene-specific map, sequence, expression, structure, function, citation, and homology data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Gene', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Gene</a></div>
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<div><a href="https://genome.ucsc.edu/cgi-bin/hgGene?db=hg38&hgg_chrom=chr12&hgg_gene=ENST00000293379.9&hgg_start=54395261&hgg_end=54419266&hgg_type=knownGene" class="mim-tip-hint" title="UCSC Genome Bioinformatics; gene-specific structure and function information with links to other databases." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC', 'domain': 'genome.ucsc.edu'})">UCSC</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimClinicalResources">
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<span class="panel-title">
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<span class="small">
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<a href="#mimClinicalResourcesLinksFold" id="mimClinicalResourcesLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
|
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<div style="display: table-row">
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<div id="mimClinicalResourcesLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Clinical Resources</div>
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</div>
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</a>
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</span>
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</span>
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</div>
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<div id="mimClinicalResourcesLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel" aria-labelledby="clinicalResources">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=135620[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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</div>
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</div>
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</div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimVariation">
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<span class="panel-title">
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<span class="small">
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<a href="#mimVariationLinksFold" id="mimVariationLinksToggle" class=" mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<span id="mimVariationLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5">▼</span> Variation
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</a>
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<div id="mimVariationLinksFold" class="panel-collapse collapse in mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.ncbi.nlm.nih.gov/clinvar?term=135620[MIM]" class="mim-tip-hint" title="ClinVar aggregates information about sequence variation and its relationship to human health." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ClinVar', 'domain': 'ncbi.nlm.nih.gov'})">ClinVar</a></div>
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<div><a href="https://www.deciphergenomics.org/gene/ITGA5/overview/clinical-info" class="mim-tip-hint" title="DECIPHER" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'DECIPHER', 'domain': 'DECIPHER'})">DECIPHER</a></div>
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<div><a href="https://gnomad.broadinstitute.org/gene/ENSG00000161638" class="mim-tip-hint" title="The Genome Aggregation Database (gnomAD), Broad Institute." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'gnomAD', 'domain': 'gnomad.broadinstitute.org'})">gnomAD</a></div>
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<div><a href="https://www.ebi.ac.uk/gwas/search?query=ITGA5" class="mim-tip-hint" title="GWAS Catalog; NHGRI-EBI Catalog of published genome-wide association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Catalog', 'domain': 'gwascatalog.org'})">GWAS Catalog </a></div>
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<div><a href="https://www.gwascentral.org/search?q=ITGA5" class="mim-tip-hint" title="GWAS Central; summary level genotype-to-phenotype information from genetic association studies." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GWAS Central', 'domain': 'gwascentral.org'})">GWAS Central </a></div>
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<div><a href="https://evs.gs.washington.edu/EVS/PopStatsServlet?searchBy=Gene+Hugo&target=ITGA5&upstreamSize=0&downstreamSize=0&x=0&y=0" class="mim-tip-hint" title="National Heart, Lung, and Blood Institute Exome Variant Server." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NHLBI EVS', 'domain': 'evs.gs.washington.edu'})">NHLBI EVS</a></div>
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<div><a href="https://www.pharmgkb.org/gene/PA29941" class="mim-tip-hint" title="Pharmacogenomics Knowledge Base; curated and annotated information regarding the effects of human genetic variations on drug response." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PharmGKB', 'domain': 'pharmgkb.org'})">PharmGKB</a></div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimAnimalModels">
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<span class="panel-title">
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<span class="small">
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<a href="#mimAnimalModelsLinksFold" id="mimAnimalModelsLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimAnimalModelsLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Animal Models</div>
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</div>
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</a>
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</span>
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<div id="mimAnimalModelsLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.alliancegenome.org/gene/HGNC:6141" class="mim-tip-hint" title="Search Across Species; explore model organism and human comparative genomics." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Alliance Genome', 'domain': 'alliancegenome.org'})">Alliance Genome</a></div>
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<div><a href="https://flybase.org/reports/FBgn0001250.html" class="mim-tip-hint" title="A Database of Drosophila Genes and Genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'FlyBase', 'domain': 'flybase.org'})">FlyBase</a></div>
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<div><a href="https://www.mousephenotype.org/data/genes/MGI:96604" class="mim-tip-hint" title="International Mouse Phenotyping Consortium." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'IMPC', 'domain': 'knockoutmouse.org'})">IMPC</a></div>
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<div><a href="http://v1.marrvel.org/search/gene/ITGA5#HomologGenesPanel" class="mim-tip-hint" title="Model organism Aggregated Resources for Rare Variant ExpLoration." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MARRVEL', 'domain': 'marrvel.org'})">MARRVEL</a></div>
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<div><a href="http://www.informatics.jax.org/marker/MGI:96604" class="mim-tip-hint" title="Mouse Genome Informatics; international database resource for the laboratory mouse, including integrated genetic, genomic, and biological data." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MGI Mouse Gene', 'domain': 'informatics.jax.org'})">MGI Mouse Gene</a></div>
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<div><a href="https://www.mmrrc.org/catalog/StrainCatalogSearchForm.php?search_query=" class="mim-tip-hint" title="Mutant Mouse Resource & Research Centers." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'MMRRC', 'domain': 'mmrrc.org'})">MMRRC</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gene/3678/ortholog/" class="mim-tip-hint" title="Orthologous genes at NCBI." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'NCBI Orthologs', 'domain': 'ncbi.nlm.nih.gov'})">NCBI Orthologs</a></div>
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<div><a href="https://www.orthodb.org/?ncbi=3678" class="mim-tip-hint" title="Hierarchical catalogue of orthologs." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'OrthoDB', 'domain': 'orthodb.org'})">OrthoDB</a></div>
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<div><a href="https://wormbase.org/db/gene/gene?name=WBGene00003929;class=Gene" class="mim-tip-hint" title="Database of the biology and genome of Caenorhabditis elegans and related nematodes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name'{'name': 'Wormbase Gene', 'domain': 'wormbase.org'})">Wormbase Gene</a></div>
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<div><a href="https://zfin.org/ZDB-GENE-031116-52" class="mim-tip-hint" title="The Zebrafish Model Organism Database." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'ZFin', 'domain': 'zfin.org'})">ZFin</a></div>
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<div class="panel panel-default" style="margin-top: 0px; border-radius: 0px">
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<div class="panel-heading mim-panel-heading" role="tab" id="mimCellularPathways">
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<span class="panel-title">
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<span class="small">
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<a href="#mimCellularPathwaysLinksFold" id="mimCellularPathwaysLinksToggle" class="collapsed mimSingletonTriangleToggle" role="button" data-toggle="collapse" data-parent="#mimExternalLinksAccordion">
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<div style="display: table-row">
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<div id="mimCellularPathwaysLinksToggleTriangle" class="small mimSingletonTriangle" style="color: #337CB5; display: table-cell;">►</div>
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<div style="display: table-cell;">Cellular Pathways</div>
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</div>
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</a>
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</span>
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</div>
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<div id="mimCellularPathwaysLinksFold" class="panel-collapse collapse mimLinksFold" role="tabpanel">
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<div class="panel-body small mim-panel-body">
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<div><a href="https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:3678" class="mim-tip-hint" title="Kyoto Encyclopedia of Genes and Genomes; diagrams of signaling pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'KEGG', 'domain': 'genome.jp'})">KEGG</a></div>
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<div><a href="https://reactome.org/content/query?q=ITGA5&species=Homo+sapiens&types=Reaction&types=Pathway&cluster=true" class="definition" title="Protein-specific information in the context of relevant cellular pathways." target="_blank" onclick="gtag('event', 'mim_outbound', {{'name': 'Reactome', 'domain': 'reactome.org'}})">Reactome</a></div>
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<span>
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<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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</span>
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</span>
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<div class="col-lg-8 col-lg-pull-2 col-md-8 col-md-pull-2 col-sm-8 col-sm-pull-2 col-xs-12">
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<div>
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<a id="title" class="mim-anchor"></a>
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<a id="number" class="mim-anchor"></a>
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<div class="text-right">
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<div>
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<span class="h3">
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<span class="mim-font mim-tip-hint" title="Gene description">
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<span class="text-danger"><strong>*</strong></span>
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135620
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</span>
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</span>
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</div>
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<div>
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<a id="preferredTitle" class="mim-anchor"></a>
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<h3>
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<span class="mim-font">
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INTEGRIN, ALPHA-5; ITGA5
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</span>
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</h3>
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</div>
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<div>
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<br />
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</div>
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<div>
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<a id="alternativeTitles" class="mim-anchor"></a>
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<div>
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<p>
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<span class="mim-font">
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<em>Alternative titles; symbols</em>
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</span>
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</p>
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</div>
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<div>
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<h4>
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<span class="mim-font">
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FIBRONECTIN RECEPTOR, ALPHA SUBUNIT; FNRA<br />
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VERY LATE ACTIVATION PROTEIN 5, ALPHA SUBUNIT; VLA5A
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</span>
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</h4>
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</div>
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<div>
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<br />
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<div>
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<a id="approvedGeneSymbols" class="mim-anchor"></a>
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<p>
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<span class="mim-text-font">
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<strong><em>HGNC Approved Gene Symbol: <a href="https://www.genenames.org/tools/search/#!/genes?query=ITGA5" class="mim-tip-hint" title="HUGO Gene Nomenclature Committee." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'HGNC', 'domain': 'genenames.org'})">ITGA5</a></em></strong>
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</span>
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</p>
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<div>
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<a id="cytogeneticLocation" class="mim-anchor"></a>
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<p>
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<span class="mim-text-font">
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<strong>
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<em>
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Cytogenetic location: <a href="/geneMap/12/468?start=-3&limit=10&highlight=468">12q13.13</a>
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Genomic coordinates <span class="small">(GRCh38)</span> : <a href="https://genome.ucsc.edu/cgi-bin/hgTracks?db=hg38&position=chr12:54395261-54419266&dgv=pack&knownGene=pack&omimGene=pack" class="mim-tip-hint" title="UCSC Genome Browser; reference sequences and working draft assemblies for a large collection of genomes." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'UCSC Genome Browser', 'domain': 'genome.ucsc.edu'})">12:54,395,261-54,419,266</a> </span>
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</em>
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</strong>
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<a href="https://www.ncbi.nlm.nih.gov/" target="_blank" class="small"> (from NCBI) </a>
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</span>
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</p>
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<div>
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<br />
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</div>
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<div>
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<a id="text" class="mim-anchor"></a>
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<h4>
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<span class="mim-font">
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<span class="mim-tip-floating" qtip_title="<strong>Looking For More References?</strong>" qtip_text="Click the 'reference plus' icon <span class='glyphicon glyphicon-plus-sign'></span> at the end of each OMIM text paragraph to see more references related to the content of the preceding paragraph.">
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<strong>TEXT</strong>
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</span>
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</span>
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</h4>
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<div>
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<a id="cloning" class="mim-anchor"></a>
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<h4 href="#mimCloningFold" id="mimCloningToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
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<span id="mimCloningToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<span class="mim-font">
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<strong>Cloning and Expression</strong>
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</span>
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</h4>
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<div id="mimCloningFold" class="collapse in mimTextToggleFold">
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<span class="mim-text-font">
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<p>The fibronectin receptor, a member of the integrin family of heterodimeric glycopeptides, mediates binding of cells to fibronectin substrata. To study the structure of the receptor, <a href="#2" class="mim-tip-reference" title="Argraves, W. S., Pytela, R., Suzuki, S., Millan, J. L., Pierschbacher, M. D., Ruoslahti, E. <strong>cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide.</strong> J. Biol. Chem. 261: 12922-12924, 1986.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2944883/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2944883</a>]" pmid="2944883">Argraves et al. (1986)</a> isolated cDNA clones coding for the alpha subunit from a placenta cDNA library. The cDNAs code for 229 amino acids from the C terminus of the alpha subunit. The deduced sequence has a hydrophobic region with properties characteristic of a membrane-spanning domain. <a href="#3" class="mim-tip-reference" title="Argraves, W. S., Suzuki, S., Arai, H., Thompson, K., Pierschbacher, M. D., Ruoslahti, E. <strong>Amino acid sequence of the human fibronectin receptor.</strong> J. Cell Biol. 105: 1183-1190, 1987.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2958481/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2958481</a>] [<a href="https://doi.org/10.1083/jcb.105.3.1183" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="2958481">Argraves et al. (1987)</a> deduced the amino acid sequence from cDNA. The alpha subunit, which is processed into 2 polypeptides disulfide-bonded to one another, has 1,008 amino acids; the beta subunit has 778 amino acids. <a href="#4" class="mim-tip-reference" title="Fitzgerald, L. A., Poncz, M., Steiner, B., Rall, S. C., Jr., Bennett, J. S., Phillips, D. R. <strong>Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.</strong> Biochemistry 26: 8158-8165, 1987.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2450560/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2450560</a>] [<a href="https://doi.org/10.1021/bi00399a021" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="2450560">Fitzgerald et al. (1987)</a> presented comparisons of the cDNA-derived protein sequences of fibronectin receptor, vitronectin receptor (<a href="/entry/193210">193210</a>), and platelet glycoprotein IIb (<a href="/entry/607759">607759</a>). <a href="https://pubmed.ncbi.nlm.nih.gov/?term=2944883+2450560+2958481" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<div>
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<br />
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</div>
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<div>
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<a id="geneFunction" class="mim-anchor"></a>
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<h4 href="#mimGeneFunctionFold" id="mimGeneFunctionToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
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<span id="mimGeneFunctionToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<span class="mim-font">
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<strong>Gene Function</strong>
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</span>
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</h4>
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</div>
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<div id="mimGeneFunctionFold" class="collapse in mimTextToggleFold">
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<span class="mim-text-font">
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<p><a href="#7" class="mim-tip-reference" title="Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Konig, W., Backert, S. <strong>Helicobacter exploits integrin for type IV secretion and kinase activation.</strong> Nature 449: 862-866, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17943123/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17943123</a>] [<a href="https://doi.org/10.1038/nature06187" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17943123">Kwok et al. (2007)</a> found that the Helicobacter pylori (see <a href="/entry/600263">600263</a>) adhesin protein CagL was targeted to the bacterial type IV secretion pilus surface, where it bound and activated the ITGA5/ITGB1 (<a href="/entry/135630">135630</a>) receptor on gastric epithelial cells through its arg-gly-asp motif. CagL interaction with the integrin receptor triggered delivery of the H. pylori oncoprotein CagA into target cells and activation of FAK (PTK2; <a href="/entry/600758">600758</a>) and SRC (<a href="/entry/190090">190090</a>) tyrosine kinases. <a href="#7" class="mim-tip-reference" title="Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Konig, W., Backert, S. <strong>Helicobacter exploits integrin for type IV secretion and kinase activation.</strong> Nature 449: 862-866, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17943123/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17943123</a>] [<a href="https://doi.org/10.1038/nature06187" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17943123">Kwok et al. (2007)</a> suggested that CagL may be used as a molecular tool to better understand integrin signaling and the mechanism by which H. pylori causes gastric ulcer and cancer. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17943123" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#12" class="mim-tip-reference" title="Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., Bluestone, J. A., Sheppard, D. <strong>Loss of integrin alpha-V/beta-8 on dendritic cells causes autoimmunity and colitis in mice.</strong> Nature 449: 361-365, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17694047/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17694047</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=17694047[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature06110" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17694047">Travis et al. (2007)</a> showed that conditional loss of the TGF-beta (<a href="/entry/190180">190180</a>)-activating integrin alpha-V/beta-8 (<a href="/entry/604160">604160</a>) on leukocytes causes severe inflammatory bowel disease and age-related autoimmunity in mice. This autoimmune phenotype is largely due to lack of alpha-V/beta-8 on dendritic cells, as mice lacking alpha-V/beta-8 principally on dendritic cells develop identical immunologic abnormalities as mice lacking alpha-V/beta-8 on all leukocytes, whereas mice lacking alpha-V/beta-8 on T cells alone are phenotypically normal. <a href="#12" class="mim-tip-reference" title="Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., Bluestone, J. A., Sheppard, D. <strong>Loss of integrin alpha-V/beta-8 on dendritic cells causes autoimmunity and colitis in mice.</strong> Nature 449: 361-365, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17694047/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17694047</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=17694047[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature06110" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17694047">Travis et al. (2007)</a> further showed that dendritic cells lacking alpha-V/beta-8 failed to induce regulatory T cells in vitro, an effect that depends on TGF-beta activity. Furthermore, mice lacking alpha-V/beta-8 on dendritic cells had reduced proportions of regulatory T cells in colonic tissue. <a href="#12" class="mim-tip-reference" title="Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., Bluestone, J. A., Sheppard, D. <strong>Loss of integrin alpha-V/beta-8 on dendritic cells causes autoimmunity and colitis in mice.</strong> Nature 449: 361-365, 2007.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17694047/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17694047</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=17694047[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1038/nature06110" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="17694047">Travis et al. (2007)</a> concluded that alpha-V/beta-8-mediated TGF-beta activation by dendritic cells is essential for preventing immune dysfunction that results in inflammatory bowel disease and autoimmunity, effects that are due, at least in part, to the ability of alpha-V/beta-8 on dendritic cells to induce and/or maintain tissue regulatory cells. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17694047" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#8" class="mim-tip-reference" title="Lammermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Soldner, R., Hirsch, K., Keller, M., Forster, R., Critchley, D. R., Fassler, R., Sixt, M. <strong>Rapid leukocyte migration by integrin-independent flowing and squeezing.</strong> Nature 453: 51-55, 2008.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18451854/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18451854</a>] [<a href="https://doi.org/10.1038/nature06887" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="18451854">Lammermann et al. (2008)</a> studied the interplay between adhesive, contractile, and protrusive forces during interstitial leukocyte chemotaxis in vivo and in vitro. The authors ablated genes encoding integrin heterodimeric partners ITGA5, ITGB1, ITGB2 (<a href="/entry/600065">600065</a>), and ITGB7 (<a href="/entry/147559">147559</a>) from murine leukocytes and demonstrated that functional integrins do not contribute to migration in 3-dimensional environments. Instead, these cells migrate by the sole force of actin network expansion, which promotes protrusive flowing of the leading edge. Myosin II-dependent contraction is required only on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=18451854" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#5" class="mim-tip-reference" title="Friedland, J. C., Lee, M. H., Boettiger, D. <strong>Mechanically activated integrin switch controls alpha-5/beta-1 function.</strong> Science 323: 642-644, 2009.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/19179533/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">19179533</a>] [<a href="https://doi.org/10.1126/science.1168441" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="19179533">Friedland et al. (2009)</a> showed that the alpha-5/beta-1 (<a href="/entry/135630">135630</a>) integrin switches between relaxed and tensioned states in response to myosin II (see <a href="/entry/160776">160776</a>)-generated cytoskeletal force. Force combines with extracellular matrix stiffness to generate tension that triggers the integrin switch. This switch directly controls the alpha-5/beta-1-fibronectin bond strength through engaging the synergy site in fibronectin and is required to generate signals through phosphorylation of focal adhesion kinase. In the context of tissues, this integrin switch connects cytoskeleton and extracellular matrix mechanics to adhesion-dependent motility and signaling pathways. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=19179533" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p><a href="#10" class="mim-tip-reference" title="Sosnoski, D., Emanuel, B. S., Hawkins, A. L., van Tuinen, P., Ledbetter, D. H., Nussbaum, R. L., Kaos, F.-T., Schwartz, E., Phillips, D., Bennett, J. S., Fitzgerald, L. A., Poncz, M. <strong>Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha-subunits and for platelet glycoproteins IIb and IIIa.</strong> J. Clin. Invest. 81: 1993-1998, 1988.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2454952/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2454952</a>] [<a href="https://doi.org/10.1172/JCI113548" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="2454952">Sosnoski et al. (1988)</a> assigned the FNRA gene to chromosome 12q11-q13 by Southern analysis of somatic cell hybrid DNA. Location on chromosome 12 was confirmed by <a href="#11" class="mim-tip-reference" title="Spurr, N. K., Rooke, L. <strong>Confirmation of the assignment of the vitronectin (VNRA) and fibronectin (FNRA) receptor alpha-subunits.</strong> Ann. Hum. Genet. 55: 217-223, 1991.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1722386/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1722386</a>] [<a href="https://doi.org/10.1111/j.1469-1809.1991.tb00416.x" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1722386">Spurr and Rooke (1991)</a> by study of human/rodent somatic cell hybrids. <a href="#6" class="mim-tip-reference" title="Krissansen, G. W., Yuan, Q., Jenkins, D., Jiang, W.-M., Rooke, L., Spurr, N. K., Eccles, M., Leung, E., Watson, J. D. <strong>Chromosomal locations of the genes coding for the integrin beta-6 and beta-7 subunits.</strong> Immunogenetics 35: 58-61, 1992.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1729173/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1729173</a>] [<a href="https://doi.org/10.1007/BF00216629" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="1729173">Krissansen et al. (1992)</a> pointed out the possible significance of the fact that a related gene coding for integrin beta-7 subunit (ITGB7; <a href="/entry/147559">147559</a>) is also located on chromosome 12. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=1722386+2454952+1729173" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#1" class="mim-tip-reference" title="Adkison, L. R., White, R. A., Haney, D. M., Lee, J. C., Pusey, K. T., Gardner, J. <strong>The fibronectin receptor, alpha subunit (Itga5) maps to murine chromosome 15, distal to D15Mit16.</strong> Mammalian Genome 5: 456-457, 1994.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7919661/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7919661</a>] [<a href="https://doi.org/10.1007/BF00357009" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7919661">Adkison et al. (1994)</a> mapped the murine homolog, Itga5, to chromosome 15, distal to D15Mit16, by analysis of DNA from an interspecific backcross. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7919661" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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<p>Mouse embryos genetically null for the alpha integrin subunit develop intracerebral hemorrhages at midgestation and die shortly after birth. <a href="#9" class="mim-tip-reference" title="McCarty, J. H., Monahan-Earley, R. A., Brown, L. F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Dvorak, H. F., Wolburg, H., Bader, B. L., Dvorak, A. M., Hynes, R. O. <strong>Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alpha-v integrins.</strong> Molec. Cell. Biol. 22: 7667-7677, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12370313/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12370313</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=12370313[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1128/MCB.22.21.7667-7677.2002" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12370313">McCarty et al. (2002)</a> determined that the endothelial cells and pericytes established normal cerebral microvessels, however, light and electron microscopy revealed defective associations between cerebral microvessels and the neuroepithelial cells, glia, and neuronal precursors of the surrounding brain parenchyma. <a href="#9" class="mim-tip-reference" title="McCarty, J. H., Monahan-Earley, R. A., Brown, L. F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Dvorak, H. F., Wolburg, H., Bader, B. L., Dvorak, A. M., Hynes, R. O. <strong>Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alpha-v integrins.</strong> Molec. Cell. Biol. 22: 7667-7677, 2002.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12370313/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12370313</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=12370313[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>] [<a href="https://doi.org/10.1128/MCB.22.21.7667-7677.2002" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="12370313">McCarty et al. (2002)</a> concluded that alpha integrins provide an association between cerebral microvessels and central nervous system parenchymal cells, and defective association leads to cerebral hemorrhage. <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12370313" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p>
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Adkison, L. R., White, R. A., Haney, D. M., Lee, J. C., Pusey, K. T., Gardner, J.
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<strong>The fibronectin receptor, alpha subunit (Itga5) maps to murine chromosome 15, distal to D15Mit16.</strong>
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Mammalian Genome 5: 456-457, 1994.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7919661/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7919661</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7919661" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1007/BF00357009" target="_blank">Full Text</a>]
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Argraves, W. S., Pytela, R., Suzuki, S., Millan, J. L., Pierschbacher, M. D., Ruoslahti, E.
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<strong>cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide.</strong>
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J. Biol. Chem. 261: 12922-12924, 1986.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2944883/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2944883</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2944883" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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Argraves, W. S., Suzuki, S., Arai, H., Thompson, K., Pierschbacher, M. D., Ruoslahti, E.
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<strong>Amino acid sequence of the human fibronectin receptor.</strong>
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J. Cell Biol. 105: 1183-1190, 1987.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2958481/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2958481</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2958481" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1083/jcb.105.3.1183" target="_blank">Full Text</a>]
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Fitzgerald, L. A., Poncz, M., Steiner, B., Rall, S. C., Jr., Bennett, J. S., Phillips, D. R.
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<strong>Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.</strong>
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Biochemistry 26: 8158-8165, 1987.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2450560/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2450560</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2450560" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1021/bi00399a021" target="_blank">Full Text</a>]
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</p>
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<a id="Friedland2009" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Friedland, J. C., Lee, M. H., Boettiger, D.
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<strong>Mechanically activated integrin switch controls alpha-5/beta-1 function.</strong>
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Science 323: 642-644, 2009.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/19179533/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">19179533</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=19179533" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1126/science.1168441" target="_blank">Full Text</a>]
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</p>
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<a id="6" class="mim-anchor"></a>
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<a id="Krissansen1992" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Krissansen, G. W., Yuan, Q., Jenkins, D., Jiang, W.-M., Rooke, L., Spurr, N. K., Eccles, M., Leung, E., Watson, J. D.
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<strong>Chromosomal locations of the genes coding for the integrin beta-6 and beta-7 subunits.</strong>
|
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Immunogenetics 35: 58-61, 1992.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1729173/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1729173</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1729173" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1007/BF00216629" target="_blank">Full Text</a>]
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</p>
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<a id="7" class="mim-anchor"></a>
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<a id="Kwok2007" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Konig, W., Backert, S.
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<strong>Helicobacter exploits integrin for type IV secretion and kinase activation.</strong>
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Nature 449: 862-866, 2007.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17943123/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17943123</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17943123" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/nature06187" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="8" class="mim-anchor"></a>
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<a id="Lammermann2008" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Lammermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Soldner, R., Hirsch, K., Keller, M., Forster, R., Critchley, D. R., Fassler, R., Sixt, M.
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<strong>Rapid leukocyte migration by integrin-independent flowing and squeezing.</strong>
|
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Nature 453: 51-55, 2008.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/18451854/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">18451854</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=18451854" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/nature06887" target="_blank">Full Text</a>]
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<li>
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<a id="9" class="mim-anchor"></a>
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<a id="McCarty2002" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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McCarty, J. H., Monahan-Earley, R. A., Brown, L. F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Dvorak, H. F., Wolburg, H., Bader, B. L., Dvorak, A. M., Hynes, R. O.
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<strong>Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alpha-v integrins.</strong>
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Molec. Cell. Biol. 22: 7667-7677, 2002.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/12370313/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">12370313</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=12370313[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=12370313" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1128/MCB.22.21.7667-7677.2002" target="_blank">Full Text</a>]
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<li>
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<a id="10" class="mim-anchor"></a>
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<a id="Sosnoski1988" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Sosnoski, D., Emanuel, B. S., Hawkins, A. L., van Tuinen, P., Ledbetter, D. H., Nussbaum, R. L., Kaos, F.-T., Schwartz, E., Phillips, D., Bennett, J. S., Fitzgerald, L. A., Poncz, M.
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<strong>Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha-subunits and for platelet glycoproteins IIb and IIIa.</strong>
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J. Clin. Invest. 81: 1993-1998, 1988.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/2454952/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">2454952</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=2454952" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1172/JCI113548" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="11" class="mim-anchor"></a>
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<a id="Spurr1991" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Spurr, N. K., Rooke, L.
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<strong>Confirmation of the assignment of the vitronectin (VNRA) and fibronectin (FNRA) receptor alpha-subunits.</strong>
|
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Ann. Hum. Genet. 55: 217-223, 1991.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/1722386/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">1722386</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=1722386" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1111/j.1469-1809.1991.tb00416.x" target="_blank">Full Text</a>]
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</p>
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<li>
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<a id="12" class="mim-anchor"></a>
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<a id="Travis2007" class="mim-anchor"></a>
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<div class="">
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<p class="mim-text-font">
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Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., Bluestone, J. A., Sheppard, D.
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<strong>Loss of integrin alpha-V/beta-8 on dendritic cells causes autoimmunity and colitis in mice.</strong>
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Nature 449: 361-365, 2007.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/17694047/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">17694047</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/?term=17694047[PMID]&report=imagesdocsum" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Image', 'domain': 'ncbi.nlm.nih.gov'})">images</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=17694047" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1038/nature06110" target="_blank">Full Text</a>]
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</ol>
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<br />
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</div>
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<a id="contributors" class="mim-anchor"></a>
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<a href="#mimCollapseContributors" role="button" data-toggle="collapse"> Contributors: </a>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Ada Hamosh - updated : 3/10/2009
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<div class="row collapse" id="mimCollapseContributors">
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<div class="col-lg-offset-2 col-md-offset-4 col-sm-offset-4 col-xs-offset-2 col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Ada Hamosh - updated : 6/12/2008<br>Ada Hamosh - updated : 1/10/2008<br>Paul J. Converse - updated : 12/20/2007<br>Patricia A. Hartz - updated : 4/21/2003
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</span>
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<a id="creationDate" class="mim-anchor"></a>
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<div class="col-lg-2 col-md-2 col-sm-4 col-xs-4">
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Creation Date:
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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Victor A. McKusick : 12/15/1986
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<a id="editHistory" class="mim-anchor"></a>
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<a href="#mimCollapseEditHistory" role="button" data-toggle="collapse"> Edit History: </a>
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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<span class="mim-text-font">
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alopez : 03/12/2009
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<div class="row collapse" id="mimCollapseEditHistory">
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<span class="mim-text-font">
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terry : 3/10/2009<br>alopez : 6/17/2008<br>alopez : 6/17/2008<br>terry : 6/12/2008<br>alopez : 1/29/2008<br>alopez : 1/29/2008<br>terry : 1/10/2008<br>mgross : 12/20/2007<br>terry : 12/20/2007<br>carol : 5/14/2003<br>cwells : 4/23/2003<br>terry : 4/21/2003<br>dkim : 9/9/1998<br>mark : 6/12/1997<br>terry : 8/26/1994<br>carol : 1/13/1993<br>carol : 3/26/1992<br>supermim : 3/16/1992<br>carol : 2/26/1992<br>supermim : 3/20/1990
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</span>
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<div class="container visible-print-block">
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<h3>
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<span class="mim-font">
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<strong>*</strong> 135620
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<h3>
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<span class="mim-font">
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INTEGRIN, ALPHA-5; ITGA5
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</div>
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<div>
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<br />
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<span class="mim-font">
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<em>Alternative titles; symbols</em>
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<h4>
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<span class="mim-font">
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FIBRONECTIN RECEPTOR, ALPHA SUBUNIT; FNRA<br />
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VERY LATE ACTIVATION PROTEIN 5, ALPHA SUBUNIT; VLA5A
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</span>
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</h4>
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<span class="mim-text-font">
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<strong><em>HGNC Approved Gene Symbol: ITGA5</em></strong>
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</span>
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<strong>
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<em>
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Cytogenetic location: 12q13.13
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Genomic coordinates <span class="small">(GRCh38)</span> : 12:54,395,261-54,419,266 </span>
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</em>
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</strong>
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<span class="small">(from NCBI)</span>
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</span>
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<h4>
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<span class="mim-font">
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<strong>TEXT</strong>
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</span>
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<div>
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<h4>
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<span class="mim-font">
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<strong>Cloning and Expression</strong>
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<span class="mim-text-font">
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<p>The fibronectin receptor, a member of the integrin family of heterodimeric glycopeptides, mediates binding of cells to fibronectin substrata. To study the structure of the receptor, Argraves et al. (1986) isolated cDNA clones coding for the alpha subunit from a placenta cDNA library. The cDNAs code for 229 amino acids from the C terminus of the alpha subunit. The deduced sequence has a hydrophobic region with properties characteristic of a membrane-spanning domain. Argraves et al. (1987) deduced the amino acid sequence from cDNA. The alpha subunit, which is processed into 2 polypeptides disulfide-bonded to one another, has 1,008 amino acids; the beta subunit has 778 amino acids. Fitzgerald et al. (1987) presented comparisons of the cDNA-derived protein sequences of fibronectin receptor, vitronectin receptor (193210), and platelet glycoprotein IIb (607759). </p>
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</span>
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<div>
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<br />
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<div>
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<h4>
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<span class="mim-font">
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<strong>Gene Function</strong>
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</span>
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</h4>
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<span class="mim-text-font">
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<p>Kwok et al. (2007) found that the Helicobacter pylori (see 600263) adhesin protein CagL was targeted to the bacterial type IV secretion pilus surface, where it bound and activated the ITGA5/ITGB1 (135630) receptor on gastric epithelial cells through its arg-gly-asp motif. CagL interaction with the integrin receptor triggered delivery of the H. pylori oncoprotein CagA into target cells and activation of FAK (PTK2; 600758) and SRC (190090) tyrosine kinases. Kwok et al. (2007) suggested that CagL may be used as a molecular tool to better understand integrin signaling and the mechanism by which H. pylori causes gastric ulcer and cancer. </p><p>Travis et al. (2007) showed that conditional loss of the TGF-beta (190180)-activating integrin alpha-V/beta-8 (604160) on leukocytes causes severe inflammatory bowel disease and age-related autoimmunity in mice. This autoimmune phenotype is largely due to lack of alpha-V/beta-8 on dendritic cells, as mice lacking alpha-V/beta-8 principally on dendritic cells develop identical immunologic abnormalities as mice lacking alpha-V/beta-8 on all leukocytes, whereas mice lacking alpha-V/beta-8 on T cells alone are phenotypically normal. Travis et al. (2007) further showed that dendritic cells lacking alpha-V/beta-8 failed to induce regulatory T cells in vitro, an effect that depends on TGF-beta activity. Furthermore, mice lacking alpha-V/beta-8 on dendritic cells had reduced proportions of regulatory T cells in colonic tissue. Travis et al. (2007) concluded that alpha-V/beta-8-mediated TGF-beta activation by dendritic cells is essential for preventing immune dysfunction that results in inflammatory bowel disease and autoimmunity, effects that are due, at least in part, to the ability of alpha-V/beta-8 on dendritic cells to induce and/or maintain tissue regulatory cells. </p><p>Lammermann et al. (2008) studied the interplay between adhesive, contractile, and protrusive forces during interstitial leukocyte chemotaxis in vivo and in vitro. The authors ablated genes encoding integrin heterodimeric partners ITGA5, ITGB1, ITGB2 (600065), and ITGB7 (147559) from murine leukocytes and demonstrated that functional integrins do not contribute to migration in 3-dimensional environments. Instead, these cells migrate by the sole force of actin network expansion, which promotes protrusive flowing of the leading edge. Myosin II-dependent contraction is required only on passage through narrow gaps, where a squeezing contraction of the trailing edge propels the rigid nucleus. </p><p>Friedland et al. (2009) showed that the alpha-5/beta-1 (135630) integrin switches between relaxed and tensioned states in response to myosin II (see 160776)-generated cytoskeletal force. Force combines with extracellular matrix stiffness to generate tension that triggers the integrin switch. This switch directly controls the alpha-5/beta-1-fibronectin bond strength through engaging the synergy site in fibronectin and is required to generate signals through phosphorylation of focal adhesion kinase. In the context of tissues, this integrin switch connects cytoskeleton and extracellular matrix mechanics to adhesion-dependent motility and signaling pathways. </p>
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<strong>Mapping</strong>
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<p>Sosnoski et al. (1988) assigned the FNRA gene to chromosome 12q11-q13 by Southern analysis of somatic cell hybrid DNA. Location on chromosome 12 was confirmed by Spurr and Rooke (1991) by study of human/rodent somatic cell hybrids. Krissansen et al. (1992) pointed out the possible significance of the fact that a related gene coding for integrin beta-7 subunit (ITGB7; 147559) is also located on chromosome 12. </p><p>Adkison et al. (1994) mapped the murine homolog, Itga5, to chromosome 15, distal to D15Mit16, by analysis of DNA from an interspecific backcross. </p>
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<strong>Animal Model</strong>
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<p>Mouse embryos genetically null for the alpha integrin subunit develop intracerebral hemorrhages at midgestation and die shortly after birth. McCarty et al. (2002) determined that the endothelial cells and pericytes established normal cerebral microvessels, however, light and electron microscopy revealed defective associations between cerebral microvessels and the neuroepithelial cells, glia, and neuronal precursors of the surrounding brain parenchyma. McCarty et al. (2002) concluded that alpha integrins provide an association between cerebral microvessels and central nervous system parenchymal cells, and defective association leads to cerebral hemorrhage. </p>
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<h4>
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<span class="mim-font">
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<strong>REFERENCES</strong>
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</span>
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</h4>
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Adkison, L. R., White, R. A., Haney, D. M., Lee, J. C., Pusey, K. T., Gardner, J.
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<strong>The fibronectin receptor, alpha subunit (Itga5) maps to murine chromosome 15, distal to D15Mit16.</strong>
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Mammalian Genome 5: 456-457, 1994.
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[PubMed: 7919661]
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[Full Text: https://doi.org/10.1007/BF00357009]
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Argraves, W. S., Pytela, R., Suzuki, S., Millan, J. L., Pierschbacher, M. D., Ruoslahti, E.
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<strong>cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide.</strong>
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J. Biol. Chem. 261: 12922-12924, 1986.
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[PubMed: 2944883]
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Argraves, W. S., Suzuki, S., Arai, H., Thompson, K., Pierschbacher, M. D., Ruoslahti, E.
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<strong>Amino acid sequence of the human fibronectin receptor.</strong>
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J. Cell Biol. 105: 1183-1190, 1987.
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[PubMed: 2958481]
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[Full Text: https://doi.org/10.1083/jcb.105.3.1183]
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Fitzgerald, L. A., Poncz, M., Steiner, B., Rall, S. C., Jr., Bennett, J. S., Phillips, D. R.
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<strong>Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.</strong>
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Biochemistry 26: 8158-8165, 1987.
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[PubMed: 2450560]
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[Full Text: https://doi.org/10.1021/bi00399a021]
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</p>
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</li>
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<p class="mim-text-font">
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Friedland, J. C., Lee, M. H., Boettiger, D.
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<strong>Mechanically activated integrin switch controls alpha-5/beta-1 function.</strong>
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Science 323: 642-644, 2009.
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[PubMed: 19179533]
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[Full Text: https://doi.org/10.1126/science.1168441]
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<p class="mim-text-font">
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Krissansen, G. W., Yuan, Q., Jenkins, D., Jiang, W.-M., Rooke, L., Spurr, N. K., Eccles, M., Leung, E., Watson, J. D.
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<strong>Chromosomal locations of the genes coding for the integrin beta-6 and beta-7 subunits.</strong>
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Immunogenetics 35: 58-61, 1992.
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[PubMed: 1729173]
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[Full Text: https://doi.org/10.1007/BF00216629]
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Kwok, T., Zabler, D., Urman, S., Rohde, M., Hartig, R., Wessler, S., Misselwitz, R., Berger, J., Sewald, N., Konig, W., Backert, S.
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<strong>Helicobacter exploits integrin for type IV secretion and kinase activation.</strong>
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Nature 449: 862-866, 2007.
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[PubMed: 17943123]
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[Full Text: https://doi.org/10.1038/nature06187]
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Lammermann, T., Bader, B. L., Monkley, S. J., Worbs, T., Wedlich-Soldner, R., Hirsch, K., Keller, M., Forster, R., Critchley, D. R., Fassler, R., Sixt, M.
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<strong>Rapid leukocyte migration by integrin-independent flowing and squeezing.</strong>
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Nature 453: 51-55, 2008.
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[PubMed: 18451854]
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[Full Text: https://doi.org/10.1038/nature06887]
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McCarty, J. H., Monahan-Earley, R. A., Brown, L. F., Keller, M., Gerhardt, H., Rubin, K., Shani, M., Dvorak, H. F., Wolburg, H., Bader, B. L., Dvorak, A. M., Hynes, R. O.
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<strong>Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alpha-v integrins.</strong>
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Molec. Cell. Biol. 22: 7667-7677, 2002.
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[PubMed: 12370313]
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[Full Text: https://doi.org/10.1128/MCB.22.21.7667-7677.2002]
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Sosnoski, D., Emanuel, B. S., Hawkins, A. L., van Tuinen, P., Ledbetter, D. H., Nussbaum, R. L., Kaos, F.-T., Schwartz, E., Phillips, D., Bennett, J. S., Fitzgerald, L. A., Poncz, M.
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<strong>Chromosomal localization of the genes for the vitronectin and fibronectin receptors alpha-subunits and for platelet glycoproteins IIb and IIIa.</strong>
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J. Clin. Invest. 81: 1993-1998, 1988.
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[PubMed: 2454952]
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[Full Text: https://doi.org/10.1172/JCI113548]
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Spurr, N. K., Rooke, L.
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<strong>Confirmation of the assignment of the vitronectin (VNRA) and fibronectin (FNRA) receptor alpha-subunits.</strong>
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Ann. Hum. Genet. 55: 217-223, 1991.
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[PubMed: 1722386]
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[Full Text: https://doi.org/10.1111/j.1469-1809.1991.tb00416.x]
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Travis, M. A., Reizis, B., Melton, A. C., Masteller, E., Tang, Q., Proctor, J. M., Wang, Y., Bernstein, X., Huang, X., Reichardt, L. F., Bluestone, J. A., Sheppard, D.
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<strong>Loss of integrin alpha-V/beta-8 on dendritic cells causes autoimmunity and colitis in mice.</strong>
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Nature 449: 361-365, 2007.
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[PubMed: 17694047]
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[Full Text: https://doi.org/10.1038/nature06110]
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<div class="col-lg-6 col-md-6 col-sm-6 col-xs-6">
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Ada Hamosh - updated : 3/10/2009<br>Ada Hamosh - updated : 6/12/2008<br>Ada Hamosh - updated : 1/10/2008<br>Paul J. Converse - updated : 12/20/2007<br>Patricia A. Hartz - updated : 4/21/2003
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Victor A. McKusick : 12/15/1986
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