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<title>
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Entry
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- #112010 - BLOOD GROUP--WALDNER TYPE; WD
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- OMIM
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<a href="#phenotypeMap"><strong>Phenotype-Gene Relationships</strong></a>
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<div style="display: table-cell;">External Links</div>
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</a>
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<div><a href="https://clinicaltrials.gov/search?cond=(BLOOD GROUP--WALDNER TYPE) OR (SLC4A1)" class="mim-tip-hint" title="Clinical Trials" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Clinical Trials', 'domain': 'clinicaltrials.gov'})">Clinical Trials</a></div>
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<div><a href="https://www.diseaseinfosearch.org/x/7845" class="mim-tip-hint" title="Network of disease-specific advocacy organizations, universities, private companies, government agencies, and public policy organizations." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'Genetic Alliance', 'domain': 'diseaseinfosearch.org'})">Genetic Alliance</a></div>
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<div><a href="https://www.ncbi.nlm.nih.gov/gtr/all/tests/?term=112010[mim]" class="mim-tip-hint" title="Genetic Testing Registry." target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'GTR', 'domain': 'ncbi.nlm.nih.gov'})">GTR</a></div>
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<span>
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<span class="mim-tip-bottom" qtip_title="<strong>Looking for this gene or this phenotype in other resources?</strong>" qtip_text="Select a related resource from the dropdown menu and click for a targeted link to information directly relevant.">
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<a id="title" class="mim-anchor"></a>
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<a id="number" class="mim-anchor"></a>
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<span class="h3">
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<span class="mim-font mim-tip-hint" title="Phenotype description, molecular basis known">
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<span class="text-danger"><strong>#</strong></span>
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112010
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</span>
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</span>
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</div>
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<div>
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<a id="preferredTitle" class="mim-anchor"></a>
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<h3>
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<span class="mim-font">
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BLOOD GROUP--WALDNER TYPE; WD
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</h3>
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<div>
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<br />
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<a id="alternativeTitles" class="mim-anchor"></a>
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<span class="mim-font">
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<em>Alternative titles; symbols</em>
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</span>
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<h4>
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<span class="mim-font">
|
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WALDNER BLOOD GROUP ANTIGEN
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</span>
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</h4>
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</div>
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<div>
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<br />
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<a id="phenotypeMap" class="mim-anchor"></a>
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<h4>
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<span class="mim-font">
|
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<strong>Phenotype-Gene Relationships</strong>
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</span>
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</h4>
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<div>
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<table class="table table-bordered table-condensed table-hover small mim-table-padding">
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<th>
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Location
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</th>
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<th>
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Phenotype
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</th>
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<th>
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Phenotype <br /> MIM number
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</th>
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<th>
|
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Inheritance
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</th>
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<th>
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Phenotype <br /> mapping key
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</th>
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<th>
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Gene/Locus
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</th>
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<th>
|
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Gene/Locus <br /> MIM number
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</th>
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</tr>
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</thead>
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<tbody>
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<tr>
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<td>
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<span class="mim-font">
|
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<a href="/geneMap/17/635?start=-3&limit=10&highlight=635">
|
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17q21.31
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</a>
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</span>
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</td>
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<td>
|
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<span class="mim-font">
|
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[Blood group, Waldner]
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</span>
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</td>
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<td>
|
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<span class="mim-font">
|
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<a href="/entry/112010"> 112010 </a>
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</span>
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</td>
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<td>
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<span class="mim-font">
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</span>
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</td>
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<td>
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<span class="mim-font">
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<abbr class="mim-tip-hint" title="3 - The molecular basis of the disorder is known"> 3 </abbr>
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</td>
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<td>
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<span class="mim-font">
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SLC4A1
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</td>
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<td>
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<span class="mim-font">
|
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<a href="/entry/109270"> 109270 </a>
|
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</span>
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</td>
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<div class="btn-group">
|
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<button type="button" class="btn btn-success dropdown-toggle" data-toggle="dropdown" aria-haspopup="true" aria-expanded="false">
|
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PheneGene Graphics <span class="caret"></span>
|
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</button>
|
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<ul class="dropdown-menu" style="width: 17em;">
|
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<li><a href="/graph/linear/112010" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Linear'})"> Linear </a></li>
|
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<li><a href="/graph/radial/112010" target="_blank" onclick="gtag('event', 'mim_graph', {'destination': 'Radial'})"> Radial </a></li>
|
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</ul>
|
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</div>
|
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<span class="glyphicon glyphicon-question-sign mim-tip-hint" title="OMIM PheneGene graphics depict relationships between phenotypes, groups of related phenotypes (Phenotypic Series), and genes.<br /><a href='/static/omim/pdf/OMIM_Graphics.pdf' target='_blank'>A quick reference overview and guide (PDF)</a>"></span>
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<div>
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<br />
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<a id="text" class="mim-anchor"></a>
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<h4 href="#mimTextFold" id="mimTextToggle" class="mimTriangleToggle" style="cursor: pointer;" data-toggle="collapse">
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<span id="mimTextToggleTriangle" class="small mimTextToggleTriangle">▼</span>
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<span class="mim-font">
|
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<span class="mim-tip-floating" qtip_title="<strong>Looking For More References?</strong>" qtip_text="Click the 'reference plus' icon <span class='glyphicon glyphicon-plus-sign'></span> at the end of each OMIM text paragraph to see more references related to the content of the preceding paragraph.">
|
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<strong>TEXT</strong>
|
|
</span>
|
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</span>
|
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</h4>
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<div id="mimTextFold" class="collapse in ">
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<span class="mim-text-font">
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<p>A number sign (#) is used with this entry because of evidence that Waldner blood group expression is caused by a point mutation in the SLC4A1 gene (<a href="/entry/109270">109270</a>).</p><p><a href="#2" class="mim-tip-reference" title="Lewis, M., Kaita, H. <strong>A 'new' low incidence 'Hutterite' blood group antigen Waldner (Wd-a).</strong> Am. J. Hum. Genet. 33: 418-420, 1981.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6941697/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6941697</a>]" pmid="6941697">Lewis and Kaita (1981)</a> found a 'new' red cell antigen in Hutterites of the surname Waldner. <a href="#3" class="mim-tip-reference" title="Zelinski, T., Coghlan, G., White, L., Phillips, S. <strong>Assignment of the Waldner blood group locus (WD) to 17q12-q21.</strong> Genomics 25: 320-322, 1995.[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7774942/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7774942</a>] [<a href="https://doi.org/10.1016/0888-7543(95)80148-f" target="_blank" onclick="gtag('event', 'mim_outbound', {'destination': 'Publisher'})">Full Text</a>]" pmid="7774942">Zelinski et al. (1995)</a> stated that the WD blood group antigen had been identified in Khoisans in South Africa and in a family in Holland. By genetic linkage analysis, they showed that WD is loosely linked to the reference marker D17S41 at 17q12-q24 and closely linked to the SLC4A1 locus at 17q12-q21. <a href="https://pubmed.ncbi.nlm.nih.gov/?term=7774942+6941697" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})"><span class="glyphicon glyphicon-plus-sign mim-tip-hint" title="Click this 'reference-plus' icon to see articles related to this paragraph in PubMed."></span></a></p><p><a href="#1" class="mim-tip-reference" title="Bruce, L. J., Tanner, M. J. A., Zelinski, T. <strong>The low incidence blood group antigen, Wd(a), is associated with the substitution val557-to-met in human erythrocyte band 3. (Abstract)</strong> Transfusion 35 (suppl.): 52S only, 1995."None>Bruce et al. (1995)</a> demonstrated that the Wd(a) results from a substitution of methionine for valine-557 in erythrocyte band-3 (<a href="/entry/109270#0011">109270.0011</a>).</p>
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Bruce, L. J., Tanner, M. J. A., Zelinski, T.
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<strong>The low incidence blood group antigen, Wd(a), is associated with the substitution val557-to-met in human erythrocyte band 3. (Abstract)</strong>
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Transfusion 35 (suppl.): 52S only, 1995.
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Lewis, M., Kaita, H.
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<strong>A 'new' low incidence 'Hutterite' blood group antigen Waldner (Wd-a).</strong>
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Am. J. Hum. Genet. 33: 418-420, 1981.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/6941697/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">6941697</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=6941697" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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Zelinski, T., Coghlan, G., White, L., Phillips, S.
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<strong>Assignment of the Waldner blood group locus (WD) to 17q12-q21.</strong>
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Genomics 25: 320-322, 1995.
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[PubMed: <a href="https://pubmed.ncbi.nlm.nih.gov/7774942/" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">7774942</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/?cmd=link&linkname=pubmed_pubmed&from_uid=7774942" target="_blank" onclick="gtag('event', 'mim_outbound', {'name': 'PubMed Related', 'domain': 'pubmed.ncbi.nlm.nih.gov'})">related citations</a>]
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[<a href="https://doi.org/10.1016/0888-7543(95)80148-f" target="_blank">Full Text</a>]
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Victor A. McKusick : 6/4/1986
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carol : 12/28/2005
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alopez : 6/26/1997<br>mark : 12/26/1996<br>terry : 12/16/1996<br>carol : 2/10/1995<br>supermim : 3/16/1992<br>supermim : 3/20/1990<br>ddp : 10/26/1989<br>marie : 3/25/1988<br>root : 1/28/1988
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BLOOD GROUP--WALDNER TYPE; WD
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WALDNER BLOOD GROUP ANTIGEN
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SLC4A1
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109270
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<p>A number sign (#) is used with this entry because of evidence that Waldner blood group expression is caused by a point mutation in the SLC4A1 gene (109270).</p><p>Lewis and Kaita (1981) found a 'new' red cell antigen in Hutterites of the surname Waldner. Zelinski et al. (1995) stated that the WD blood group antigen had been identified in Khoisans in South Africa and in a family in Holland. By genetic linkage analysis, they showed that WD is loosely linked to the reference marker D17S41 at 17q12-q24 and closely linked to the SLC4A1 locus at 17q12-q21. </p><p>Bruce et al. (1995) demonstrated that the Wd(a) results from a substitution of methionine for valine-557 in erythrocyte band-3 (109270.0011).</p>
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<strong>REFERENCES</strong>
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Bruce, L. J., Tanner, M. J. A., Zelinski, T.
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<strong>The low incidence blood group antigen, Wd(a), is associated with the substitution val557-to-met in human erythrocyte band 3. (Abstract)</strong>
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Transfusion 35 (suppl.): 52S only, 1995.
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<p class="mim-text-font">
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Lewis, M., Kaita, H.
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<strong>A 'new' low incidence 'Hutterite' blood group antigen Waldner (Wd-a).</strong>
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Am. J. Hum. Genet. 33: 418-420, 1981.
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[PubMed: 6941697]
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Zelinski, T., Coghlan, G., White, L., Phillips, S.
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<strong>Assignment of the Waldner blood group locus (WD) to 17q12-q21.</strong>
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Genomics 25: 320-322, 1995.
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[PubMed: 7774942]
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[Full Text: https://doi.org/10.1016/0888-7543(95)80148-f]
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Victor A. McKusick : 6/4/1986
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carol : 12/28/2005<br>alopez : 6/26/1997<br>mark : 12/26/1996<br>terry : 12/16/1996<br>carol : 2/10/1995<br>supermim : 3/16/1992<br>supermim : 3/20/1990<br>ddp : 10/26/1989<br>marie : 3/25/1988<br>root : 1/28/1988
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NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers,
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and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal
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NOTE: OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers,
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and by advanced students in science and medicine. While the OMIM database is open to the public, users seeking information about a personal
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medical or genetic condition are urged to consult with a qualified physician for diagnosis and for answers to personal questions.
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OMIM<sup>®</sup> and Online Mendelian Inheritance in Man<sup>®</sup> are registered trademarks of the Johns Hopkins University.
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Copyright<sup>®</sup> 1966-2025 Johns Hopkins University.
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Thank you in advance for your generous support, <br />
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Ada Hamosh, MD, MPH <br />
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Scientific Director, OMIM <br />
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