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<meta name="keywords" content="CN280943, colorectal cancer, familial, disease or syndrome, familial colorectal cancer, hereditary colorectal cancer, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=965772
|
||
ConceptID=CN280943
|
||
-->
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||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Familial colorectal cancer</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>965772</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">CN280943</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>colorectal cancer, familial; familial colorectal cancer; hereditary colorectal cancer</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0023113" target="_blank">MONDO:0023113</a></td></tr>
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||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln">Familial colon cancer is a cluster of colon cancer within a family. Most cases of colon cancer occur sporadically in people with little to no family history of the condition. Approximately 3-5% of colon cancer is considered 'hereditary' and is thought to be caused by an inherited predisposition tocolon cancer that is passed down through a family in an autosomal dominant or autosomal recessive manner. In some of these families, the underlying genetic cause is not known; however, many of these cases are caused by changes (mutations) in the APC , MYH , MLH1 , MSH2 , MSH6 , PMS2 , EPCAM , PTEN , STK11 , SMAD4 , BMPR1A , NTHL1 , POLE , and POLD1 genes (which are associated with hereditary cancer syndromes). An additional 10-30% of people diagnosed with colon cancer have a significant family history of the condition but have no identifiable mutation in a gene known to cause a hereditary predisposition to colon cancer. These clusters of colon cancer are likely due to a combination of gene(s) and other shared factors such as environment and lifestyle. High-risk cancer screening and other preventative measures such as prophylactic surgeries are typically recommended in people who have an increased risk for colon cancer based on their personal and/or family histories. [from <a title="Monarch Initiative" href="https://monarchinitiative.org/" class="defSource" target="_blank">MONDO</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0009404[DISCUI]&test_type=Clinical" ref="ncbi_uid=3171">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=3171" ref="ncbi_uid=3171">V</a></span></span><span class="TLline"><a href="/medgen/3171" ref="tree=GTR&ncbi_uid=3171&link_uid=3171" title="View MedGen record for 'Neoplasm of the large intestine'">Neoplasm of the large intestine</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/91125" ref="tree=GTR&ncbi_uid=91125&link_uid=91125" title="View MedGen record for 'Benign neoplasm of large intestine'">Benign neoplasm of large intestine</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0346629[DISCUI]&test_type=Clinical" ref="ncbi_uid=83428">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1211/" ref="ncbi_uid=83428">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=83428" ref="ncbi_uid=83428">V</a></span></span><span class="TLline"><a href="/medgen/83428" ref="tree=GTR&ncbi_uid=83428&link_uid=83428" title="View MedGen record for 'Colorectal cancer'">Colorectal cancer</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007102[DISCUI]&test_type=Clinical" ref="ncbi_uid=2839">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=2839" target="_blank" href="/omim/114500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=2839" ref="ncbi_uid=2839">V</a></span></span><span class="TLline"><a href="/medgen/2839" ref="tree=GTR&ncbi_uid=2839&link_uid=2839" title="View MedGen record for 'Colon cancer'">Colon cancer</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0699790[DISCUI]&test_type=Clinical" ref="ncbi_uid=147065">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0699790[DISCUI]&test_type=Research" ref="ncbi_uid=147065">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1211/" ref="ncbi_uid=147065">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=147065" ref="ncbi_uid=147065">V</a></span></span><span class="TLline"><a href="/medgen/147065" ref="tree=GTR&ncbi_uid=147065&link_uid=147065" title="View MedGen record for 'Carcinoma of colon'">Carcinoma of colon</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/101033" ref="tree=GTR&ncbi_uid=101033&link_uid=101033" title="View MedGen record for 'Colon lymphoma'">Colon lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/272493" ref="tree=GTR&ncbi_uid=272493&link_uid=272493" title="View MedGen record for 'Colon sarcoma'">Colon sarcoma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0009402[DISCUI]&test_type=Clinical" ref="ncbi_uid=3170">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=3170" target="_blank" href="/omim/114500">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=3170" ref="ncbi_uid=3170">V</a></span></span><span class="TLline"><a href="/medgen/3170" ref="tree=GTR&ncbi_uid=3170&link_uid=3170" title="View MedGen record for 'Colorectal carcinoma'">Colorectal carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/474455" ref="tree=GTR&ncbi_uid=474455&link_uid=474455" title="View MedGen record for 'Colorectal lymphoma'">Colorectal lymphoma</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN280943[DISCUI]&test_type=Clinical" ref="ncbi_uid=965772">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=CN280943[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=965772">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=965772" ref="ncbi_uid=965772">V</a></span></span><span class="TLline">Familial colorectal cancer</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0949022[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=181763">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/181763" ref="tree=GTR&ncbi_uid=181763&link_uid=181763" title="View MedGen record for 'Malignant tumor of rectum'">Malignant tumor of rectum</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0007113[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=40100">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/40100" ref="tree=GTR&ncbi_uid=40100&link_uid=40100" title="View MedGen record for 'Rectal carcinoma'">Rectal carcinoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/233393" ref="tree=GTR&ncbi_uid=233393&link_uid=233393" title="View MedGen record for 'Rectum lymphoma'">Rectum lymphoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/277577" ref="tree=GTR&ncbi_uid=277577&link_uid=277577" title="View MedGen record for 'Rectum sarcoma'">Rectum sarcoma</a></span></li></ul></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/232130" ref="tree=MeSH" title="MedGen record for Disorder by Site">Disorder by Site</a></span><ul><li><span class="TLline"><a href="/medgen/8970" ref="tree=MeSH" title="MedGen record for Disorder of gastrointestinal tract">Disorder of gastrointestinal tract</a></span><ul><li><span class="TLline"><a href="/medgen/7130" ref="tree=MeSH" title="MedGen record for Intestinal disorder">Intestinal disorder</a></span><ul><li><span class="TLline"><a href="/medgen/43932" ref="tree=MeSH" title="MedGen record for Intestinal neoplasm">Intestinal neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/87562" ref="tree=MeSH" title="MedGen record for Intestinal cancer">Intestinal cancer</a></span><ul><li><span class="TLline"><a href="/medgen/83428" ref="tree=MeSH" title="MedGen record for Colorectal cancer">Colorectal cancer</a></span><ul><li><span class="matched_ds">Familial colorectal cancer</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/27546013">Familial colorectal cancer: Patient assessment, surveillance and surgical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kennelly RP,
|
||
Gryfe R,
|
||
Winter DC</span><br />
|
||
<span class="medgenPMjournal">Eur J Surg Oncol</span>
|
||
2017 Feb;43(2):294-302.
|
||
Epub 2016 Jul 27
|
||
doi: 10.1016/j.ejso.2016.07.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27546013" target="_blank">27546013</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20555108">Familial colorectal cancer risk: ESMO Clinical Practice Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Balmaña J,
|
||
Castells A,
|
||
Cervantes A;
|
||
ESMO Guidelines Working Group</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2010 May;21 Suppl 5:v78-81.
|
||
doi: 10.1093/annonc/mdq169.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20555108" target="_blank">20555108</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17656264">MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kim JC,
|
||
Roh SA,
|
||
Yoon YS,
|
||
Kim HC,
|
||
Park IJ</span><br />
|
||
<span class="medgenPMjournal">Cancer Genet Cytogenet</span>
|
||
2007 Jul 15;176(2):172-4.
|
||
doi: 10.1016/j.cancergencyto.2007.04.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17656264" target="_blank">17656264</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22familial%20colorectal%20cancer%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (25)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng151" target="_blank">UK NICE Guideline NG151, Colorectal cancer, 2021</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389505">Genetics of Colorectal Cancer (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389505" target="_blank">26389505</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389258">Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389258" target="_blank">26389258</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div><h3 class="subhead">External</h3><h3 class="nl vspace"><a href="http://www.nchpeg.org/documents/crc/11-0456%20Fact%20sheets%20(MSI%20and%20IHC%20testing).pdf" target="_blank">AMA/NCHPEG, 2012</a></h3>
|
||
</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37852706">Role of colonoscopy in colorectal cancer screening: Available evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gimeno-García AZ,
|
||
Quintero E</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2023 Oct;66:101838.
|
||
Epub 2023 May 14
|
||
doi: 10.1016/j.bpg.2023.101838.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37852706" target="_blank">37852706</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36153112">Approach to Familial Predisposition to Colorectal Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ballester V,
|
||
Cruz-Correa M</span><br />
|
||
<span class="medgenPMjournal">Gastroenterol Clin North Am</span>
|
||
2022 Sep;51(3):593-607.
|
||
Epub 2022 Aug 30
|
||
doi: 10.1016/j.gtc.2022.06.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36153112" target="_blank">36153112</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35988967">Familial colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mangas-Sanjuan C,
|
||
Jover R</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2022 Jun-Aug;58-59:101798.
|
||
Epub 2022 Mar 25
|
||
doi: 10.1016/j.bpg.2022.101798.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35988967" target="_blank">35988967</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30520562">Early-onset colorectal cancer in young individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mauri G,
|
||
Sartore-Bianchi A,
|
||
Russo AG,
|
||
Marsoni S,
|
||
Bardelli A,
|
||
Siena S</span><br />
|
||
<span class="medgenPMjournal">Mol Oncol</span>
|
||
2019 Feb;13(2):109-131.
|
||
Epub 2018 Dec 22
|
||
doi: 10.1002/1878-0261.12417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30520562" target="_blank">30520562</a><a href="/pmc/articles/PMC6360363" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19454462">Familial colorectal cancer risk: ESMO clinical recommendations.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vasen HF,
|
||
van der Meulen-de Jong AE,
|
||
de Vos Tot Nederveen Cappel WH,
|
||
Oliveira J;
|
||
ESMO Guidelines Working Group</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2009 May;20 Suppl 4:51-3.
|
||
doi: 10.1093/annonc/mdp127.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19454462" target="_blank">19454462</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20colorectal%20cancer%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (270)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37852706">Role of colonoscopy in colorectal cancer screening: Available evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gimeno-García AZ,
|
||
Quintero E</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2023 Oct;66:101838.
|
||
Epub 2023 May 14
|
||
doi: 10.1016/j.bpg.2023.101838.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37852706" target="_blank">37852706</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35988967">Familial colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mangas-Sanjuan C,
|
||
Jover R</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Gastroenterol</span>
|
||
2022 Jun-Aug;58-59:101798.
|
||
Epub 2022 Mar 25
|
||
doi: 10.1016/j.bpg.2022.101798.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35988967" target="_blank">35988967</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30520562">Early-onset colorectal cancer in young individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mauri G,
|
||
Sartore-Bianchi A,
|
||
Russo AG,
|
||
Marsoni S,
|
||
Bardelli A,
|
||
Siena S</span><br />
|
||
<span class="medgenPMjournal">Mol Oncol</span>
|
||
2019 Feb;13(2):109-131.
|
||
Epub 2018 Dec 22
|
||
doi: 10.1002/1878-0261.12417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30520562" target="_blank">30520562</a><a href="/pmc/articles/PMC6360363" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25955461">Familial colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lung MS,
|
||
Trainer AH,
|
||
Campbell I,
|
||
Lipton L</span><br />
|
||
<span class="medgenPMjournal">Intern Med J</span>
|
||
2015 May;45(5):482-91.
|
||
doi: 10.1111/imj.12736.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25955461" target="_blank">25955461</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7863096">Hereditary and familial colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ponz de Leon M</span><br />
|
||
<span class="medgenPMjournal">Recent Results Cancer Res</span>
|
||
1994;136:203-37.
|
||
doi: 10.1007/978-3-642-85076-9_15.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7863096" target="_blank">7863096</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20colorectal%20cancer%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (196)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33673279">Whole Exome Sequencing Identifies APCDD1 and HDAC5 Genes as Potentially Cancer Predisposing in Familial Colorectal Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Skopelitou D,
|
||
Miao B,
|
||
Srivastava A,
|
||
Kumar A,
|
||
Kuswick M,
|
||
Dymerska D,
|
||
Paramasivam N,
|
||
Schlesner M,
|
||
Lubinski J,
|
||
Hemminki K,
|
||
Försti A,
|
||
Bandapalli OR</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2021 Feb 12;22(4)
|
||
doi: 10.3390/ijms22041837.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33673279" target="_blank">33673279</a><a href="/pmc/articles/PMC7917948" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31525516">Effects of Family History on Relative and Absolute Risks for Colorectal Cancer: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roos VH,
|
||
Mangas-Sanjuan C,
|
||
Rodriguez-Girondo M,
|
||
Medina-Prado L,
|
||
Steyerberg EW,
|
||
Bossuyt PMM,
|
||
Dekker E,
|
||
Jover R,
|
||
van Leerdam ME</span><br />
|
||
<span class="medgenPMjournal">Clin Gastroenterol Hepatol</span>
|
||
2019 Dec;17(13):2657-2667.e9.
|
||
Epub 2019 Sep 13
|
||
doi: 10.1016/j.cgh.2019.09.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31525516" target="_blank">31525516</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25855726">Thyroid dysfunction, thyroid hormone replacement and colorectal cancer risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Boursi B,
|
||
Haynes K,
|
||
Mamtani R,
|
||
Yang YX</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst</span>
|
||
2015 Jun;107(6):djv084.
|
||
Epub 2015 Apr 8
|
||
doi: 10.1093/jnci/djv084.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25855726" target="_blank">25855726</a><a href="/pmc/articles/PMC4838062" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20555108">Familial colorectal cancer risk: ESMO Clinical Practice Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Balmaña J,
|
||
Castells A,
|
||
Cervantes A;
|
||
ESMO Guidelines Working Group</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2010 May;21 Suppl 5:v78-81.
|
||
doi: 10.1093/annonc/mdq169.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20555108" target="_blank">20555108</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7863096">Hereditary and familial colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ponz de Leon M</span><br />
|
||
<span class="medgenPMjournal">Recent Results Cancer Res</span>
|
||
1994;136:203-37.
|
||
doi: 10.1007/978-3-642-85076-9_15.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7863096" target="_blank">7863096</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20colorectal%20cancer%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (26)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32449991">Candidate genes for hereditary colorectal cancer: Mutational screening and systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Belhadj S,
|
||
Terradas M,
|
||
Munoz-Torres PM,
|
||
Aiza G,
|
||
Navarro M,
|
||
Capellá G,
|
||
Valle L</span><br />
|
||
<span class="medgenPMjournal">Hum Mutat</span>
|
||
2020 Sep;41(9):1563-1576.
|
||
Epub 2020 Jul 28
|
||
doi: 10.1002/humu.24057.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32449991" target="_blank">32449991</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30520562">Early-onset colorectal cancer in young individuals.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mauri G,
|
||
Sartore-Bianchi A,
|
||
Russo AG,
|
||
Marsoni S,
|
||
Bardelli A,
|
||
Siena S</span><br />
|
||
<span class="medgenPMjournal">Mol Oncol</span>
|
||
2019 Feb;13(2):109-131.
|
||
Epub 2018 Dec 22
|
||
doi: 10.1002/1878-0261.12417.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30520562" target="_blank">30520562</a><a href="/pmc/articles/PMC6360363" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20555108">Familial colorectal cancer risk: ESMO Clinical Practice Guidelines.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Balmaña J,
|
||
Castells A,
|
||
Cervantes A;
|
||
ESMO Guidelines Working Group</span><br />
|
||
<span class="medgenPMjournal">Ann Oncol</span>
|
||
2010 May;21 Suppl 5:v78-81.
|
||
doi: 10.1093/annonc/mdq169.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20555108" target="_blank">20555108</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19540838">Concepts in familial colorectal cancer: where do we stand and what is the future?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Castells A,
|
||
Castellví-Bel S,
|
||
Balaguer F</span><br />
|
||
<span class="medgenPMjournal">Gastroenterology</span>
|
||
2009 Aug;137(2):404-9.
|
||
Epub 2009 Jun 21
|
||
doi: 10.1053/j.gastro.2009.06.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19540838" target="_blank">19540838</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7863096">Hereditary and familial colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ponz de Leon M</span><br />
|
||
<span class="medgenPMjournal">Recent Results Cancer Res</span>
|
||
1994;136:203-37.
|
||
doi: 10.1007/978-3-642-85076-9_15.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7863096" target="_blank">7863096</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20colorectal%20cancer%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (112)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32449991">Candidate genes for hereditary colorectal cancer: Mutational screening and systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Belhadj S,
|
||
Terradas M,
|
||
Munoz-Torres PM,
|
||
Aiza G,
|
||
Navarro M,
|
||
Capellá G,
|
||
Valle L</span><br />
|
||
<span class="medgenPMjournal">Hum Mutat</span>
|
||
2020 Sep;41(9):1563-1576.
|
||
Epub 2020 Jul 28
|
||
doi: 10.1002/humu.24057.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32449991" target="_blank">32449991</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31555933">Novel candidates in early-onset familial colorectal cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jansen AML,
|
||
Ghosh P,
|
||
Dakal TC,
|
||
Slavin TP,
|
||
Boland CR,
|
||
Goel A</span><br />
|
||
<span class="medgenPMjournal">Fam Cancer</span>
|
||
2020 Jan;19(1):1-10.
|
||
Epub 2019 Sep 25
|
||
doi: 10.1007/s10689-019-00145-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31555933" target="_blank">31555933</a><a href="/pmc/articles/PMC7241873" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26185367">Familial colorectal cancer screening: When and what to do?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Del Vecchio Blanco G,
|
||
Paoluzi OA,
|
||
Sileri P,
|
||
Rossi P,
|
||
Sica G,
|
||
Pallone F</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2015 Jul 14;21(26):7944-53.
|
||
doi: 10.3748/wjg.v21.i26.7944.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26185367" target="_blank">26185367</a><a href="/pmc/articles/PMC4499338" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25779305">Familial colorectal cancer syndromes: an overview of clinical management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sammour T,
|
||
Hayes IP,
|
||
Hill AG,
|
||
Macrae FA,
|
||
Winter DC</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Gastroenterol Hepatol</span>
|
||
2015 Jun;9(6):757-64.
|
||
Epub 2015 Mar 16
|
||
doi: 10.1586/17474124.2015.1026328.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25779305" target="_blank">25779305</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25071323">Familial colorectal cancer: a review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Armelao F,
|
||
de Pretis G</span><br />
|
||
<span class="medgenPMjournal">World J Gastroenterol</span>
|
||
2014 Jul 28;20(28):9292-8.
|
||
doi: 10.3748/wjg.v20.i28.9292.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25071323" target="_blank">25071323</a><a href="/pmc/articles/PMC4110560" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20colorectal%20cancer%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (127)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34980016">Mapping psychosocial interventions in familial colorectal cancer: a rapid systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ciucă A,
|
||
Moldovan R,
|
||
Băban A</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2022 Jan 3;22(1):8.
|
||
doi: 10.1186/s12885-021-09086-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34980016" target="_blank">34980016</a><a href="/pmc/articles/PMC8722202" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32449991">Candidate genes for hereditary colorectal cancer: Mutational screening and systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Belhadj S,
|
||
Terradas M,
|
||
Munoz-Torres PM,
|
||
Aiza G,
|
||
Navarro M,
|
||
Capellá G,
|
||
Valle L</span><br />
|
||
<span class="medgenPMjournal">Hum Mutat</span>
|
||
2020 Sep;41(9):1563-1576.
|
||
Epub 2020 Jul 28
|
||
doi: 10.1002/humu.24057.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32449991" target="_blank">32449991</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29096939">Familial Colorectal Cancer Type X (FCCTX) and the correlation with various genes-A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nejadtaghi M,
|
||
Jafari H,
|
||
Farrokhi E,
|
||
Samani KG</span><br />
|
||
<span class="medgenPMjournal">Curr Probl Cancer</span>
|
||
2017 Nov-Dec;41(6):388-397.
|
||
Epub 2017 Oct 18
|
||
doi: 10.1016/j.currproblcancer.2017.10.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29096939" target="_blank">29096939</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28927785">Do alcoholic beverages, obesity and other nutritional factors modify the risk of familial colorectal cancer? A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fardet A,
|
||
Druesne-Pecollo N,
|
||
Touvier M,
|
||
Latino-Martel P</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncol Hematol</span>
|
||
2017 Nov;119:94-112.
|
||
Epub 2017 Sep 7
|
||
doi: 10.1016/j.critrevonc.2017.09.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28927785" target="_blank">28927785</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11693338">A systematic review and meta-analysis of familial colorectal cancer risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Johns LE,
|
||
Houlston RS</span><br />
|
||
<span class="medgenPMjournal">Am J Gastroenterol</span>
|
||
2001 Oct;96(10):2992-3003.
|
||
doi: 10.1111/j.1572-0241.2001.04677.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11693338" target="_blank">11693338</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20colorectal%20cancer%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (7)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
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|
||
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||
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||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet mgSection" id="ID_106">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (44)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A1%5F3" target="_blank">Immunohistochemistry (1)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F15" target="_blank">Methylation analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F12" target="_blank">Microsatellite instability testing (MSI) (3)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (3)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (2)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&test_type=Research" target="_blank">Research (1)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (5)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (60)</a></li>
|
||
<li><a href="/gtr/tests?term=CN280943%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (11)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=CN280943%5bDISCUI%5d" target="_blank">See all (82)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://clinicaltrials.gov/search?cond=Familial%20colorectal%20cancer" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22familial%20colorectal%20cancer%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Familial%20colorectal%20cancer%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng151">NICE, 2021</a><div>UK NICE Guideline NG151, Colorectal cancer, 2021</div></li></ul></div>
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