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<!--
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UID=808058
|
||
ConceptID=CN221249
|
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-->
|
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Methadone response</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>808058</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">CN221249</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Drug:</td>
|
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<td>
|
||
<div class="divPopper rprt" id="drug_6335"><div><strong>Methadone</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>6335</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0025605</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pharmacologic Substance</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine and morphine-like agents. The characteristic morphine-like effects include analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. However, the detoxification symptoms between morphine-like agents and methadone differ in that the onset of methadone''s withdrawal symptoms is slower, the course is more prolonged and the symptoms are less severe. [from NCI]</div></div>
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|
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33880737">Restless Legs Syndrome: Contemporary Diagnosis and Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gossard TR,
|
||
Trotti LM,
|
||
Videnovic A,
|
||
St Louis EK</span><br />
|
||
<span class="medgenPMjournal">Neurotherapeutics</span>
|
||
2021 Jan;18(1):140-155.
|
||
Epub 2021 Apr 20
|
||
doi: 10.1007/s13311-021-01019-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33880737" target="_blank">33880737</a><a href="/pmc/articles/PMC8116476" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32564328">Methadone for Pain Management: A Pharmacotherapeutic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kreutzwiser D,
|
||
Tawfic QA</span><br />
|
||
<span class="medgenPMjournal">CNS Drugs</span>
|
||
2020 Aug;34(8):827-839.
|
||
doi: 10.1007/s40263-020-00743-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32564328" target="_blank">32564328</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31418602">Pain management in opioid maintenance treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Koller G,
|
||
Schwarzer A,
|
||
Halfter K,
|
||
Soyka M</span><br />
|
||
<span class="medgenPMjournal">Expert Opin Pharmacother</span>
|
||
2019 Nov;20(16):1993-2005.
|
||
Epub 2019 Aug 16
|
||
doi: 10.1080/14656566.2019.1652270.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31418602" target="_blank">31418602</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22methadone%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (2957)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e72841bf-364b-49b1-8e69-7e26ddcd2657" target="_blank">DailyMed Drug Label, METHADONE HYDROCHLORIDE, 2021</a></h3>
|
||
<h3 class="nl vspace"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5e70e915-b946-4a80-bcc6-3f49bc30f2f5" target="_blank">DailyMed Drug Label, methadone, 2007</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
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<div class="portlet mgSection" id="ID_103">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38341456">The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haupt LM,
|
||
Haywood A,
|
||
Sutherland HG,
|
||
Yu C,
|
||
Albury CL,
|
||
Pharasi A,
|
||
Zunk M,
|
||
George R,
|
||
Griffiths LR,
|
||
Good P,
|
||
Hardy J</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2024 Feb 10;14(1):3411.
|
||
doi: 10.1038/s41598-024-54009-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38341456" target="_blank">38341456</a><a href="/pmc/articles/PMC10858860" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36261449">Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ozberk D,
|
||
Haywood A,
|
||
Sutherland HG,
|
||
Yu C,
|
||
Albury CL,
|
||
Zunk M,
|
||
George R,
|
||
Good P,
|
||
Griffiths LR,
|
||
Hardy J,
|
||
Haupt LM</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Oct 19;12(1):17422.
|
||
doi: 10.1038/s41598-022-21180-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36261449" target="_blank">36261449</a><a href="/pmc/articles/PMC9582209" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29168075">Pharmacogenetics of Methadone Response.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fonseca F,
|
||
Torrens M</span><br />
|
||
<span class="medgenPMjournal">Mol Diagn Ther</span>
|
||
2018 Feb;22(1):57-78.
|
||
doi: 10.1007/s40291-017-0311-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29168075" target="_blank">29168075</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24489693">Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dennis BB,
|
||
Bawor M,
|
||
Thabane L,
|
||
Sohani Z,
|
||
Samaan Z</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2014;9(1):e86114.
|
||
Epub 2014 Jan 29
|
||
doi: 10.1371/journal.pone.0086114.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24489693" target="_blank">24489693</a><a href="/pmc/articles/PMC3906028" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10517040">Methadone response in advanced cancer patients with pain followed at home.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mercadante S,
|
||
Casuccio A,
|
||
Agnello A,
|
||
Barresi L</span><br />
|
||
<span class="medgenPMjournal">J Pain Symptom Manage</span>
|
||
1999 Sep;18(3):188-92.
|
||
doi: 10.1016/s0885-3924(99)00048-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10517040" target="_blank">10517040</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Methadone%20response%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38341456">The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haupt LM,
|
||
Haywood A,
|
||
Sutherland HG,
|
||
Yu C,
|
||
Albury CL,
|
||
Pharasi A,
|
||
Zunk M,
|
||
George R,
|
||
Griffiths LR,
|
||
Good P,
|
||
Hardy J</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2024 Feb 10;14(1):3411.
|
||
doi: 10.1038/s41598-024-54009-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38341456" target="_blank">38341456</a><a href="/pmc/articles/PMC10858860" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36261449">Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ozberk D,
|
||
Haywood A,
|
||
Sutherland HG,
|
||
Yu C,
|
||
Albury CL,
|
||
Zunk M,
|
||
George R,
|
||
Good P,
|
||
Griffiths LR,
|
||
Hardy J,
|
||
Haupt LM</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Oct 19;12(1):17422.
|
||
doi: 10.1038/s41598-022-21180-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36261449" target="_blank">36261449</a><a href="/pmc/articles/PMC9582209" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32705966">Pharmacogenomics of methadone: a narrative review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Packiasabapathy S,
|
||
Aruldhas BW,
|
||
Horn N,
|
||
Overholser BR,
|
||
Quinney SK,
|
||
Renschler JS,
|
||
Sadhasivam S</span><br />
|
||
<span class="medgenPMjournal">Pharmacogenomics</span>
|
||
2020 Aug;21(12):871-887.
|
||
Epub 2020 Jul 24
|
||
doi: 10.2217/pgs-2020-0040.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32705966" target="_blank">32705966</a><a href="/pmc/articles/PMC7444627" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29168075">Pharmacogenetics of Methadone Response.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fonseca F,
|
||
Torrens M</span><br />
|
||
<span class="medgenPMjournal">Mol Diagn Ther</span>
|
||
2018 Feb;22(1):57-78.
|
||
doi: 10.1007/s40291-017-0311-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29168075" target="_blank">29168075</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18422375">Interindividual variability of methadone response: impact of genetic polymorphism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Kantelip JP,
|
||
Gerritsen-van Schieveen P,
|
||
Davani S</span><br />
|
||
<span class="medgenPMjournal">Mol Diagn Ther</span>
|
||
2008;12(2):109-24.
|
||
doi: 10.1007/BF03256276.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18422375" target="_blank">18422375</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Methadone%20response%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32705966">Pharmacogenomics of methadone: a narrative review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Packiasabapathy S,
|
||
Aruldhas BW,
|
||
Horn N,
|
||
Overholser BR,
|
||
Quinney SK,
|
||
Renschler JS,
|
||
Sadhasivam S</span><br />
|
||
<span class="medgenPMjournal">Pharmacogenomics</span>
|
||
2020 Aug;21(12):871-887.
|
||
Epub 2020 Jul 24
|
||
doi: 10.2217/pgs-2020-0040.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32705966" target="_blank">32705966</a><a href="/pmc/articles/PMC7444627" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Methadone%20response%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38341456">The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haupt LM,
|
||
Haywood A,
|
||
Sutherland HG,
|
||
Yu C,
|
||
Albury CL,
|
||
Pharasi A,
|
||
Zunk M,
|
||
George R,
|
||
Griffiths LR,
|
||
Good P,
|
||
Hardy J</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2024 Feb 10;14(1):3411.
|
||
doi: 10.1038/s41598-024-54009-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38341456" target="_blank">38341456</a><a href="/pmc/articles/PMC10858860" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36261449">Association of KCNJ6 rs2070995 and methadone response for pain management in advanced cancer at end-of-life.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ozberk D,
|
||
Haywood A,
|
||
Sutherland HG,
|
||
Yu C,
|
||
Albury CL,
|
||
Zunk M,
|
||
George R,
|
||
Good P,
|
||
Griffiths LR,
|
||
Hardy J,
|
||
Haupt LM</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2022 Oct 19;12(1):17422.
|
||
doi: 10.1038/s41598-022-21180-w.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36261449" target="_blank">36261449</a><a href="/pmc/articles/PMC9582209" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32705966">Pharmacogenomics of methadone: a narrative review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Packiasabapathy S,
|
||
Aruldhas BW,
|
||
Horn N,
|
||
Overholser BR,
|
||
Quinney SK,
|
||
Renschler JS,
|
||
Sadhasivam S</span><br />
|
||
<span class="medgenPMjournal">Pharmacogenomics</span>
|
||
2020 Aug;21(12):871-887.
|
||
Epub 2020 Jul 24
|
||
doi: 10.2217/pgs-2020-0040.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32705966" target="_blank">32705966</a><a href="/pmc/articles/PMC7444627" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24489693">Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dennis BB,
|
||
Bawor M,
|
||
Thabane L,
|
||
Sohani Z,
|
||
Samaan Z</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2014;9(1):e86114.
|
||
Epub 2014 Jan 29
|
||
doi: 10.1371/journal.pone.0086114.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24489693" target="_blank">24489693</a><a href="/pmc/articles/PMC3906028" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18422375">Interindividual variability of methadone response: impact of genetic polymorphism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Kantelip JP,
|
||
Gerritsen-van Schieveen P,
|
||
Davani S</span><br />
|
||
<span class="medgenPMjournal">Mol Diagn Ther</span>
|
||
2008;12(2):109-24.
|
||
doi: 10.1007/BF03256276.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18422375" target="_blank">18422375</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Methadone%20response%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/24489693">Impact of ABCB1 and CYP2B6 genetic polymorphisms on methadone metabolism, dose and treatment response in patients with opioid addiction: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dennis BB,
|
||
Bawor M,
|
||
Thabane L,
|
||
Sohani Z,
|
||
Samaan Z</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2014;9(1):e86114.
|
||
Epub 2014 Jan 29
|
||
doi: 10.1371/journal.pone.0086114.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24489693" target="_blank">24489693</a><a href="/pmc/articles/PMC3906028" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Methadone%20response%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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</div>
|
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|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=CN221249%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (6)</a></li>
|
||
<li><a href="/gtr/tests?term=CN221249%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=CN221249%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (12)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=CN221249%5bDISCUI%5d" target="_blank">See all (13)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.pharmgkb.org/chemical/PA450401" target="_blank">PharmGKB</a></li><li><a href="https://clinicaltrials.gov/search?cond=Methadone%20response" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22methadone%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Methadone%20response%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e72841bf-364b-49b1-8e69-7e26ddcd2657">DailyMed Drug Label, 2021</a><div>DailyMed Drug Label, METHADONE HYDROCHLORIDE, 2021</div></li><li><a target="_blank" href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=5e70e915-b946-4a80-bcc6-3f49bc30f2f5">DailyMed Drug Label, 2007</a><div>DailyMed Drug Label, methadone, 2007</div></li></ul></div>
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