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<meta name="keywords" content="CN184091, aminoglycoside antibacterials response, aminoglycoside response, mt-ts1, sign or symptom, trmu, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Mitochondrial nonsyndromic hearing loss and deafness is characterized by sensorineural hearing loss (SNHL) of variable onset and severity. Pathogenic variants in MT-RNR1 can be associated with predisposition to aminoglycoside ototoxicity and/or late-onset SNHL. Hearing loss associated with aminoglycoside ototoxicity is bilateral and severe to profound, occurring within a few days to weeks after administration of any amount (even a single dose) of an aminoglycoside antibiotic such as gentamycin, tobramycin, amikacin, kanamycin, or streptomycin. Pathogenic variants in MT-TS1 are usually associated with childhood onset of SNHL that is generally nonsyndromic – although the MT-TS1 substitution m.7445A>G has been found in some families who also have palmoplantar keratoderma (scaling, hyperkeratosis, and honeycomb appearance of the skin of the palms, soles, and heels)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=776458
|
||
ConceptID=CN184091
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Aminoglycoside antibacterials response</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>776458</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier assigned by MedGen (starting with CN) for terms that cannot be identified in NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">CN184091</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Sign or Symptom</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Aminoglycoside response</td></tr>
|
||
<tr><td>Drug:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="drug_8114"><div><strong>Aminoglycoside antibacterials</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>8114</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003233</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Antibiotic</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any antibiotic containing amino-modified sugars originally isolated from various Streptomyces and Micromonospora species. Aminoglycoside antibiotics bind to the 16S RNA of the bacterial 30S ribosomal subunit, inhibiting translation and protein synthesis. Aminoglycoside use is associated with ototoxicity, neurotxicity and nephrotoxicity. [from NCI]</div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#drug_8114" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aminoglycoside antibacterials</a></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="MT-TS1 - ID: 4574 - NCBI Gene" href="/gene/4574" class="medgenPMinfo">MT-TS1</a>; <a target="_blank" title="TRMU - ID: 55687 - NCBI Gene" href="/gene/55687" class="medgenPMinfo">TRMU</a> (22q13.31)</td></tr>
|
||
<tr><td><a class="help" data-jig="ncbipopper" href="#target-gene-related">Related genes:<img src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div id="target-gene-related" class="display-none">
|
||
Gene(s) associated with related conditions. For conditions<br />
|
||
in a hierarchy, the parent condition will list the genes<br />
|
||
associated with the children conditions.</div></td>
|
||
<td><a target="_blank" href="/gene/6052">RNR1</a>, <a target="_blank" href="/gene/4549">RNR1</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1422" target="_blank">Nonsyndromic Hearing Loss and Deafness, Mitochondrial</a></div><div>Mitochondrial nonsyndromic hearing loss and deafness is characterized by sensorineural hearing loss (SNHL) of variable onset and severity. Pathogenic variants in MT-RNR1 can be associated with predisposition to aminoglycoside ototoxicity and/or late-onset SNHL. Hearing loss associated with aminoglycoside ototoxicity is bilateral and severe to profound, occurring within a few days to weeks after administration of any amount (even a single dose) of an aminoglycoside antibiotic such as gentamycin, tobramycin, amikacin, kanamycin, or streptomycin. Pathogenic variants in MT-TS1 are usually associated with childhood onset of SNHL that is generally nonsyndromic – although the MT-TS1 substitution m.7445A>G has been found in some families who also have palmoplantar keratoderma (scaling, hyperkeratosis, and honeycomb appearance of the skin of the palms, soles, and heels). [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Summary" target="NBK1422">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Diagnosis" target="NBK1422">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Clinical_Characteristics" target="NBK1422">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Genetically_Related_Allelic" target="NBK1422">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Differential_Diagnosis" target="NBK1422">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Management" target="NBK1422">Management</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Genetic_Counseling" target="NBK1422">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Resources" target="NBK1422">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Molecular_Genetics" target="NBK1422">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.Chapter_Notes" target="NBK1422">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1422#mt-deafness.References" target="NBK1422">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Shin-ichi Usami | Shin-ya Nishio <a href="/books/NBK1422" target="NBK1422" title="NCBI Bookshelf: Nonsyndromic Hearing Loss and Deafness, Mitochondrial">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN184091[DISCUI]&test_type=Clinical" ref="ncbi_uid=776458">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1422/" ref="ncbi_uid=776458">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline">Aminoglycoside antibacterials response</span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN184546[DISCUI]&test_type=Clinical" ref="ncbi_uid=776649">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1422/" ref="ncbi_uid=776649">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/776649" ref="tree=GTR&ncbi_uid=776649&link_uid=776649" title="View MedGen record for 'Amikacin response'">Amikacin response</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1838854[DISCUI]&test_type=Clinical" ref="ncbi_uid=374074">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=374074" target="_blank" href="/omim/516030">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/?term=(NBK1422%20OR%20NBK1434)%20AND%20gene%5Bbook%5D&showtype=onebook" ref="ncbi_uid=374074">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=374074" ref="ncbi_uid=374074">V</a></span></span><span class="TLline"><a href="/medgen/374074" ref="tree=GTR&ncbi_uid=374074&link_uid=374074" title="View MedGen record for 'Aminoglycoside-induced deafness'">Aminoglycoside-induced deafness</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN184225[DISCUI]&test_type=Clinical" ref="ncbi_uid=776533">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1422/" ref="ncbi_uid=776533">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=776533" ref="ncbi_uid=776533">V</a></span></span><span class="TLline"><a href="/medgen/776533" ref="tree=GTR&ncbi_uid=776533&link_uid=776533" title="View MedGen record for 'Gentamicin response'">Gentamicin response</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN184547[DISCUI]&test_type=Clinical" ref="ncbi_uid=776650">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1422/" ref="ncbi_uid=776650">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/776650" ref="tree=GTR&ncbi_uid=776650&link_uid=776650" title="View MedGen record for 'Kanamycin response'">Kanamycin response</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1154708[DISCUI]&test_type=Clinical" ref="ncbi_uid=776646">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1422/" ref="ncbi_uid=776646">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/776646" ref="tree=GTR&ncbi_uid=776646&link_uid=776646" title="View MedGen record for 'Streptomycin response'">Streptomycin response</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN184545[DISCUI]&test_type=Clinical" ref="ncbi_uid=776648">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1422/" ref="ncbi_uid=776648">G</a></span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/776648" ref="tree=GTR&ncbi_uid=776648&link_uid=776648" title="View MedGen record for 'Tobramycin response'">Tobramycin response</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="matched_ds">Aminoglycoside antibacterials response</span><ul><li><span class="TLline"><a href="/medgen/776649" ref="tree=MeSH" title="MedGen record for Amikacin response">Amikacin response</a></span></li><li><span class="TLline"><a href="/medgen/374074" ref="tree=MeSH" title="MedGen record for Aminoglycoside-induced deafness">Aminoglycoside-induced deafness</a></span></li><li><span class="TLline"><a href="/medgen/776533" ref="tree=MeSH" title="MedGen record for Gentamicin response">Gentamicin response</a></span></li><li><span class="TLline"><a href="/medgen/776650" ref="tree=MeSH" title="MedGen record for Kanamycin response">Kanamycin response</a></span></li><li><span class="TLline"><a href="/medgen/776646" ref="tree=MeSH" title="MedGen record for Streptomycin response">Streptomycin response</a></span></li><li><span class="TLline"><a href="/medgen/776648" ref="tree=MeSH" title="MedGen record for Tobramycin response">Tobramycin response</a></span></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36522272">Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pintado V,
|
||
Ruiz-Garbajosa P,
|
||
Aguilera-Alonso D,
|
||
Baquero-Artigao F,
|
||
Bou G,
|
||
Cantón R,
|
||
Grau S,
|
||
Gutiérrez-Gutiérrez B,
|
||
Larrosa N,
|
||
Machuca I,
|
||
Martínez Martínez L,
|
||
Montero MM,
|
||
Morte-Romea E,
|
||
Oliver A,
|
||
Paño-Pardo JR,
|
||
Sorlí L</span><br />
|
||
<span class="medgenPMjournal">Enferm Infecc Microbiol Clin (Engl Ed)</span>
|
||
2023 Jun-Jul;41(6):360-370.
|
||
Epub 2022 Dec 13
|
||
doi: 10.1016/j.eimce.2022.06.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36522272" target="_blank">36522272</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34314673">Treatment of Mycobacterium abscessus Pulmonary Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Griffith DE,
|
||
Daley CL</span><br />
|
||
<span class="medgenPMjournal">Chest</span>
|
||
2022 Jan;161(1):64-75.
|
||
Epub 2021 Jul 24
|
||
doi: 10.1016/j.chest.2021.07.035.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34314673" target="_blank">34314673</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34161555">Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Milosavljevic MN,
|
||
Milosavljevic JZ,
|
||
Kocovic AG,
|
||
Stefanovic SM,
|
||
Jankovic SM,
|
||
Djesevic M,
|
||
Milentijevic MN</span><br />
|
||
<span class="medgenPMjournal">Rev Inst Med Trop Sao Paulo</span>
|
||
2021;63:e49.
|
||
Epub 2021 Jun 18
|
||
doi: 10.1590/S1678-9946202163049.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34161555" target="_blank">34161555</a><a href="/pmc/articles/PMC8216692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(aminoglycoside%20antibacterials%20response)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (311)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3><h3 class="nl vspace"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=abd1f64e-4283-4370-aae8-3666316aa36e" target="_blank">DailyMed Drug Label, STREPTOMYCIN, 2013</a></h3>
|
||
<h3 class="nl vspace"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6aab2c4c-148a-4fce-af07-41cd086d9e9c" target="_blank">DailyMed Drug Label, TOBRAMYCIN, 2013</a></h3>
|
||
<h3 class="nl vspace"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6ec3129b-c53b-4bdb-913d-a2d0060fa140" target="_blank">DailyMed Drug Label, AMIKACIN, 2013</a></h3>
|
||
<h3 class="nl vspace"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a73a5453-c091-43fd-aae2-d992152363b1" target="_blank">DailyMed Drug Label, GENTAMICIN, 2012</a></h3>
|
||
<h3 class="nl vspace"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d4865638-1259-4eef-a73c-fe919af6e850" target="_blank">DailyMed Drug Label, KANAMYCIN, 2012</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36053506">Bedaquiline-Pretomanid-Linezolid Regimens for Drug-Resistant Tuberculosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Conradie F,
|
||
Bagdasaryan TR,
|
||
Borisov S,
|
||
Howell P,
|
||
Mikiashvili L,
|
||
Ngubane N,
|
||
Samoilova A,
|
||
Skornykova S,
|
||
Tudor E,
|
||
Variava E,
|
||
Yablonskiy P,
|
||
Everitt D,
|
||
Wills GH,
|
||
Sun E,
|
||
Olugbosi M,
|
||
Egizi E,
|
||
Li M,
|
||
Holsta A,
|
||
Timm J,
|
||
Bateson A,
|
||
Crook AM,
|
||
Fabiane SM,
|
||
Hunt R,
|
||
McHugh TD,
|
||
Tweed CD,
|
||
Foraida S,
|
||
Mendel CM,
|
||
Spigelman M;
|
||
ZeNix Trial Team</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2022 Sep 1;387(9):810-823.
|
||
doi: 10.1056/NEJMoa2119430.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36053506" target="_blank">36053506</a><a href="/pmc/articles/PMC9490302" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33565627">From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wicha SG,
|
||
Märtson AG,
|
||
Nielsen EI,
|
||
Koch BCP,
|
||
Friberg LE,
|
||
Alffenaar JW,
|
||
Minichmayr IK;
|
||
International Society of Anti-Infective Pharmacology (ISAP), the PK/PD study group of the European Society of Clinical Microbiology, Infectious Diseases (EPASG)</span><br />
|
||
<span class="medgenPMjournal">Clin Pharmacol Ther</span>
|
||
2021 Apr;109(4):928-941.
|
||
Epub 2021 Mar 16
|
||
doi: 10.1002/cpt.2202.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33565627" target="_blank">33565627</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21288078">Fidaxomicin versus vancomycin for Clostridium difficile infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Louie TJ,
|
||
Miller MA,
|
||
Mullane KM,
|
||
Weiss K,
|
||
Lentnek A,
|
||
Golan Y,
|
||
Gorbach S,
|
||
Sears P,
|
||
Shue YK;
|
||
OPT-80-003 Clinical Study Group</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2011 Feb 3;364(5):422-31.
|
||
doi: 10.1056/NEJMoa0910812.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21288078" target="_blank">21288078</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17266591">Aminoglycoside-induced ototoxicity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Selimoglu E</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Des</span>
|
||
2007;13(1):119-26.
|
||
doi: 10.2174/138161207779313731.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17266591" target="_blank">17266591</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6338150">Ototoxicity: etiology and issues.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">D'Alonzo BJ,
|
||
Cantor AB</span><br />
|
||
<span class="medgenPMjournal">J Fam Pract</span>
|
||
1983 Mar;16(3):489-94.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6338150" target="_blank">6338150</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aminoglycoside%20antibacterials%20response%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1270)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36522272">Executive summary of the consensus document of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the diagnosis and antimicrobial treatment of infections due to carbapenem-resistant Gram-negative bacteria.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pintado V,
|
||
Ruiz-Garbajosa P,
|
||
Aguilera-Alonso D,
|
||
Baquero-Artigao F,
|
||
Bou G,
|
||
Cantón R,
|
||
Grau S,
|
||
Gutiérrez-Gutiérrez B,
|
||
Larrosa N,
|
||
Machuca I,
|
||
Martínez Martínez L,
|
||
Montero MM,
|
||
Morte-Romea E,
|
||
Oliver A,
|
||
Paño-Pardo JR,
|
||
Sorlí L</span><br />
|
||
<span class="medgenPMjournal">Enferm Infecc Microbiol Clin (Engl Ed)</span>
|
||
2023 Jun-Jul;41(6):360-370.
|
||
Epub 2022 Dec 13
|
||
doi: 10.1016/j.eimce.2022.06.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36522272" target="_blank">36522272</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34161555">Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Milosavljevic MN,
|
||
Milosavljevic JZ,
|
||
Kocovic AG,
|
||
Stefanovic SM,
|
||
Jankovic SM,
|
||
Djesevic M,
|
||
Milentijevic MN</span><br />
|
||
<span class="medgenPMjournal">Rev Inst Med Trop Sao Paulo</span>
|
||
2021;63:e49.
|
||
Epub 2021 Jun 18
|
||
doi: 10.1590/S1678-9946202163049.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34161555" target="_blank">34161555</a><a href="/pmc/articles/PMC8216692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12427228">Endophthalmitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Elder MJ,
|
||
Morlet N;
|
||
EPSWA. Endophthalmitis Population Study of Western Australia</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Ophthalmol</span>
|
||
2002 Dec;30(6):394-8.
|
||
doi: 10.1046/j.1442-9071.2002.00567.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12427228" target="_blank">12427228</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11190351">Antipseudomonal antibiotics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Giamarellou H,
|
||
Antoniadou A</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2001 Jan;85(1):19-42, v.
|
||
doi: 10.1016/s0025-7125(05)70303-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11190351" target="_blank">11190351</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8170691">Neomycin ototoxicity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Langman AW</span><br />
|
||
<span class="medgenPMjournal">Otolaryngol Head Neck Surg</span>
|
||
1994 Apr;110(4):441-4.
|
||
doi: 10.1177/019459989411000416.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8170691" target="_blank">8170691</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aminoglycoside%20antibacterials%20response%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (838)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34750338">Therapeutic Drug Monitoring of Antibiotics: Defining the Therapeutic Range.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abdul-Aziz MH,
|
||
Brady K,
|
||
Cotta MO,
|
||
Roberts JA</span><br />
|
||
<span class="medgenPMjournal">Ther Drug Monit</span>
|
||
2022 Feb 1;44(1):19-31.
|
||
doi: 10.1097/FTD.0000000000000940.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34750338" target="_blank">34750338</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34161555">Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Milosavljevic MN,
|
||
Milosavljevic JZ,
|
||
Kocovic AG,
|
||
Stefanovic SM,
|
||
Jankovic SM,
|
||
Djesevic M,
|
||
Milentijevic MN</span><br />
|
||
<span class="medgenPMjournal">Rev Inst Med Trop Sao Paulo</span>
|
||
2021;63:e49.
|
||
Epub 2021 Jun 18
|
||
doi: 10.1590/S1678-9946202163049.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34161555" target="_blank">34161555</a><a href="/pmc/articles/PMC8216692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21288078">Fidaxomicin versus vancomycin for Clostridium difficile infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Louie TJ,
|
||
Miller MA,
|
||
Mullane KM,
|
||
Weiss K,
|
||
Lentnek A,
|
||
Golan Y,
|
||
Gorbach S,
|
||
Sears P,
|
||
Shue YK;
|
||
OPT-80-003 Clinical Study Group</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2011 Feb 3;364(5):422-31.
|
||
doi: 10.1056/NEJMoa0910812.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21288078" target="_blank">21288078</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17266591">Aminoglycoside-induced ototoxicity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Selimoglu E</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Des</span>
|
||
2007;13(1):119-26.
|
||
doi: 10.2174/138161207779313731.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17266591" target="_blank">17266591</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19667545">Optimal antibiotic dosing. The pharmacokinetic-pharmacodynamic interface.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reed MD</span><br />
|
||
<span class="medgenPMjournal">Postgrad Med</span>
|
||
2000 Dec;108(7 Suppl Contemporaty):17-24.
|
||
doi: 10.3810/pgm.12.2000.suppl10.52.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19667545" target="_blank">19667545</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aminoglycoside%20antibacterials%20response%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2348)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34314673">Treatment of Mycobacterium abscessus Pulmonary Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Griffith DE,
|
||
Daley CL</span><br />
|
||
<span class="medgenPMjournal">Chest</span>
|
||
2022 Jan;161(1):64-75.
|
||
Epub 2021 Jul 24
|
||
doi: 10.1016/j.chest.2021.07.035.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34314673" target="_blank">34314673</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30403305">Reappraisal of Contemporary Pharmacokinetic and Pharmacodynamic Principles for Informing Aminoglycoside Dosing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bland CM,
|
||
Pai MP,
|
||
Lodise TP</span><br />
|
||
<span class="medgenPMjournal">Pharmacotherapy</span>
|
||
2018 Dec;38(12):1229-1238.
|
||
doi: 10.1002/phar.2193.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30403305" target="_blank">30403305</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21288078">Fidaxomicin versus vancomycin for Clostridium difficile infection.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Louie TJ,
|
||
Miller MA,
|
||
Mullane KM,
|
||
Weiss K,
|
||
Lentnek A,
|
||
Golan Y,
|
||
Gorbach S,
|
||
Sears P,
|
||
Shue YK;
|
||
OPT-80-003 Clinical Study Group</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2011 Feb 3;364(5):422-31.
|
||
doi: 10.1056/NEJMoa0910812.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21288078" target="_blank">21288078</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17266591">Aminoglycoside-induced ototoxicity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Selimoglu E</span><br />
|
||
<span class="medgenPMjournal">Curr Pharm Des</span>
|
||
2007;13(1):119-26.
|
||
doi: 10.2174/138161207779313731.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17266591" target="_blank">17266591</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6997210">Therapeutic drug monitoring of aminoglycoside antibiotics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reeves DS</span><br />
|
||
<span class="medgenPMjournal">Infection</span>
|
||
1980;8 Suppl 3:S 313-20.
|
||
doi: 10.1007/BF01639603.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6997210" target="_blank">6997210</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aminoglycoside%20antibacterials%20response%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (745)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34314673">Treatment of Mycobacterium abscessus Pulmonary Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Griffith DE,
|
||
Daley CL</span><br />
|
||
<span class="medgenPMjournal">Chest</span>
|
||
2022 Jan;161(1):64-75.
|
||
Epub 2021 Jul 24
|
||
doi: 10.1016/j.chest.2021.07.035.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34314673" target="_blank">34314673</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34161555">Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Milosavljevic MN,
|
||
Milosavljevic JZ,
|
||
Kocovic AG,
|
||
Stefanovic SM,
|
||
Jankovic SM,
|
||
Djesevic M,
|
||
Milentijevic MN</span><br />
|
||
<span class="medgenPMjournal">Rev Inst Med Trop Sao Paulo</span>
|
||
2021;63:e49.
|
||
Epub 2021 Jun 18
|
||
doi: 10.1590/S1678-9946202163049.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34161555" target="_blank">34161555</a><a href="/pmc/articles/PMC8216692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33483370">Gut Microbiota Condition the Therapeutic Efficacy of Trastuzumab in HER2-Positive Breast Cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Di Modica M,
|
||
Gargari G,
|
||
Regondi V,
|
||
Bonizzi A,
|
||
Arioli S,
|
||
Belmonte B,
|
||
De Cecco L,
|
||
Fasano E,
|
||
Bianchi F,
|
||
Bertolotti A,
|
||
Tripodo C,
|
||
Villani L,
|
||
Corsi F,
|
||
Guglielmetti S,
|
||
Balsari A,
|
||
Triulzi T,
|
||
Tagliabue E</span><br />
|
||
<span class="medgenPMjournal">Cancer Res</span>
|
||
2021 Apr 15;81(8):2195-2206.
|
||
Epub 2021 Jan 22
|
||
doi: 10.1158/0008-5472.CAN-20-1659.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33483370" target="_blank">33483370</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30655633">Multidisciplinary approach to prostatitis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Magri V,
|
||
Boltri M,
|
||
Cai T,
|
||
Colombo R,
|
||
Cuzzocrea S,
|
||
De Visschere P,
|
||
Giuberti R,
|
||
Granatieri CM,
|
||
Latino MA,
|
||
Larganà G,
|
||
Leli C,
|
||
Maierna G,
|
||
Marchese V,
|
||
Massa E,
|
||
Matteelli A,
|
||
Montanari E,
|
||
Morgia G,
|
||
Naber KG,
|
||
Papadouli V,
|
||
Perletti G,
|
||
Rekleiti N,
|
||
Russo GI,
|
||
Sensini A,
|
||
Stamatiou K,
|
||
Trinchieri A,
|
||
Wagenlehner FME</span><br />
|
||
<span class="medgenPMjournal">Arch Ital Urol Androl</span>
|
||
2019 Jan 18;90(4):227-248.
|
||
doi: 10.4081/aiua.2018.4.227.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30655633" target="_blank">30655633</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30403305">Reappraisal of Contemporary Pharmacokinetic and Pharmacodynamic Principles for Informing Aminoglycoside Dosing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bland CM,
|
||
Pai MP,
|
||
Lodise TP</span><br />
|
||
<span class="medgenPMjournal">Pharmacotherapy</span>
|
||
2018 Dec;38(12):1229-1238.
|
||
doi: 10.1002/phar.2193.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30403305" target="_blank">30403305</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aminoglycoside%20antibacterials%20response%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (864)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34161555">Antimicrobial treatment of Corynebacterium striatum invasive infections: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Milosavljevic MN,
|
||
Milosavljevic JZ,
|
||
Kocovic AG,
|
||
Stefanovic SM,
|
||
Jankovic SM,
|
||
Djesevic M,
|
||
Milentijevic MN</span><br />
|
||
<span class="medgenPMjournal">Rev Inst Med Trop Sao Paulo</span>
|
||
2021;63:e49.
|
||
Epub 2021 Jun 18
|
||
doi: 10.1590/S1678-9946202163049.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34161555" target="_blank">34161555</a><a href="/pmc/articles/PMC8216692" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33172776">Adult parameningial alveolar rhabdomyosarcoma: Case report and literature review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barthère X,
|
||
Guillerm S,
|
||
Quero L,
|
||
Le Maignan C,
|
||
Torossian N,
|
||
Verillaud B,
|
||
Itti R,
|
||
Hennequin C</span><br />
|
||
<span class="medgenPMjournal">Cancer Radiother</span>
|
||
2020 Dec;24(8):870-875.
|
||
Epub 2020 Nov 7
|
||
doi: 10.1016/j.canrad.2020.03.015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33172776" target="_blank">33172776</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31760892">Pediatric pharmacokinetics of the antibiotics in the access and watch groups of the 2019 WHO model list of essential medicines for children: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rashed AN,
|
||
Jackson C,
|
||
Gastine S,
|
||
Hsia Y,
|
||
Bielicki J,
|
||
Standing JF,
|
||
Tomlin S,
|
||
Sharland M</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Clin Pharmacol</span>
|
||
2019 Dec;12(12):1099-1106.
|
||
Epub 2019 Nov 25
|
||
doi: 10.1080/17512433.2019.1693257.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31760892" target="_blank">31760892</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27494904">Amikacin use and therapeutic drug monitoring in adults: do dose regimens and drug exposures affect either outcome or adverse events? A systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jenkins A,
|
||
Thomson AH,
|
||
Brown NM,
|
||
Semple Y,
|
||
Sluman C,
|
||
MacGowan A,
|
||
Lovering AM,
|
||
Wiffen PJ;
|
||
(BSAC Working Party on Therapeutic Drug Monitoring)</span><br />
|
||
<span class="medgenPMjournal">J Antimicrob Chemother</span>
|
||
2016 Oct;71(10):2754-9.
|
||
Epub 2016 Jul 11
|
||
doi: 10.1093/jac/dkw250.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27494904" target="_blank">27494904</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9142773">Single daily dosing of aminoglycosides in immunocompromised adults: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hatala R,
|
||
Dinh TT,
|
||
Cook DJ</span><br />
|
||
<span class="medgenPMjournal">Clin Infect Dis</span>
|
||
1997 May;24(5):810-5.
|
||
doi: 10.1093/clinids/24.5.810.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9142773" target="_blank">9142773</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Aminoglycoside%20antibacterials%20response%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
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|
||
</div>
|
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<div class=" bottom">
|
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|
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</div>
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|
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</div>
|
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</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
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<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
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<div class="rightCol mgCol">
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul id="my-toc"></ul></div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=CN184091%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (1)</a></li>
|
||
<li><a href="/gtr/tests?term=CN184091%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=CN184091%5bDISCUI%5d" target="_blank">See all (2)</a></total></li>
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</ul></div>
|
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</div>
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|
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<div class="portlet mgSection" id="ID_119">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.pharmgkb.org/chemical/PA452167" target="_blank">PharmGKB</a></li><li><a href="https://www.pharmgkb.org/chemical/PA452167" target="_blank">PharmGKB</a></li><li><a href="https://clinicaltrials.gov/search?cond=Aminoglycoside%20antibacterials%20response" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
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<div class="portlet mgSection" id="ID_121">
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(aminoglycoside%20antibacterials%20response)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Aminoglycoside%20antibacterials%20response%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=abd1f64e-4283-4370-aae8-3666316aa36e">DailyMed Drug Label, 2013</a><div>DailyMed Drug Label, STREPTOMYCIN, 2013</div></li><li><a target="_blank" href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6aab2c4c-148a-4fce-af07-41cd086d9e9c">DailyMed Drug Label, 2013</a><div>DailyMed Drug Label, TOBRAMYCIN, 2013</div></li><li><a target="_blank" href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6ec3129b-c53b-4bdb-913d-a2d0060fa140">DailyMed Drug Label, 2013</a><div>DailyMed Drug Label, AMIKACIN, 2013</div></li><li><a target="_blank" href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=a73a5453-c091-43fd-aae2-d992152363b1">DailyMed Drug Label, 2012</a><div>DailyMed Drug Label, GENTAMICIN, 2012</div></li><li><a target="_blank" href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d4865638-1259-4eef-a73c-fe919af6e850">DailyMed Drug Label, 2012</a><div>DailyMed Drug Label, KANAMYCIN, 2012</div></li></ul></div>
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