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<meta name="keywords" content="C5935637, disease or syndrome, hrob, odg11, ovarian dysgenesis 11, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Ovarian dysgenesis-11 (ODG11) is characterized by primary amenorrhea and delayed puberty, with absent ovaries on pelvic ultrasound (Tucker et al., 2022; Wu et al., 2023). For a discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
|
||
UID=1856331
|
||
ConceptID=C5935637
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Ovarian dysgenesis 11<span class="h1sub">(ODG11)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1856331</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C5935637</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>ODG11; OVARIAN DYSGENESIS 11</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="HROB - ID: 78995 - NCBI Gene" href="/gene/78995" class="medgenPMinfo">HROB</a> (17q21.31)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0971176" target="_blank">MONDO:0971176</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/620897" target="_blank">620897</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Ovarian dysgenesis-11 (ODG11) is characterized by primary amenorrhea and delayed puberty, with absent ovaries on pelvic ultrasound (Tucker et al., 2022; Wu et al., 2023). For a discussion of genetic heterogeneity of ovarian dysgenesis, see ODG1 (233300). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
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<div class="portlet mgSection" id="ID_102">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_115918"><div><strong>Primary amenorrhea</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>115918</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0232939</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormally late or absent menarche in a female with normal secondary sexual characteristics.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/115918">Feature record</a> | <a href="/medgen?term=%22Primary%20amenorrhea%22%5BClinical%20Features%5D%20OR%20115918%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_452348"><div><strong>Aplasia of the ovary</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>452348</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0266368</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Aplasia, that is failure to develop, of the ovary.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/452348">Feature record</a> | <a href="/medgen?term=%22Aplasia%20of%20the%20ovary%22%5BClinical%20Features%5D%20OR%20452348%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_46203"><div><strong>Delayed puberty</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>46203</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0034012</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/46203">Feature record</a> | <a href="/medgen?term=%22Delayed%20puberty%22%5BClinical%20Features%5D%20OR%2046203%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_69129"><div><strong>Decreased serum estradiol</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>69129</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0241011</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A reduction below normal concentration of estradiol in the circulation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/69129">Feature record</a> | <a href="/medgen?term=%22Decreased%20serum%20estradiol%22%5BClinical%20Features%5D%20OR%2069129%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_184929"><div><strong>Delayed menarche</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>184929</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0949173</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">First period after the age of 15 years.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/184929">Feature record</a> | <a href="/medgen?term=%22Delayed%20menarche%22%5BClinical%20Features%5D%20OR%20184929%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_867192"><div><strong>Elevated circulating follicle stimulating hormone level</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>867192</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4021550</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An elevated concentration of follicle-stimulating hormone in the blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/867192">Feature record</a> | <a href="/medgen?term=%22Elevated%20circulating%20follicle%20stimulating%20hormone%20level%22%5BClinical%20Features%5D%20OR%20867192%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_868698"><div><strong>Elevated circulating luteinizing hormone level</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868698</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4023101</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An elevated concentration of luteinizing hormone in the blood.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/868698">Feature record</a> | <a href="/medgen?term=%22Elevated%20circulating%20luteinizing%20hormone%20level%22%5BClinical%20Features%5D%20OR%20868698%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1391876"><div><strong>Decreased circulating antimullerian hormone circulation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1391876</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4476972</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A reduction below the normal range of the antimullerian hormone in the circulation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1391876">Feature record</a> | <a href="/medgen?term=%22Decreased%20circulating%20antimullerian%20hormone%20circulation%22%5BClinical%20Features%5D%20OR%201391876%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1391876" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased circulating antimullerian hormone circulation</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_69129" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Decreased serum estradiol</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_184929" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Delayed menarche</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_46203" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Delayed puberty</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_867192" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated circulating follicle stimulating hormone level</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_868698" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated circulating luteinizing hormone level</a></span></li></ul></li><li><span class="TLline">Abnormality of the genitourinary system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_452348" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aplasia of the ovary</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_115918" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary amenorrhea</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33347618">Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tso LO,
|
||
Costello MF,
|
||
Albuquerque LET,
|
||
Andriolo RB,
|
||
Macedo CR</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2020 Dec 21;12(12):CD006105.
|
||
doi: 10.1002/14651858.CD006105.pub4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33347618" target="_blank">33347618</a><a href="/pmc/articles/PMC8171384" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32296393">Editorial: Congenital Adrenal Hyperplasia, Unresolved Issues and Implications on Clinical Management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Livadas S,
|
||
Stratakis CA,
|
||
Macut D</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2020;11:170.
|
||
Epub 2020 Mar 31
|
||
doi: 10.3389/fendo.2020.00170.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32296393" target="_blank">32296393</a><a href="/pmc/articles/PMC7136517" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26509855">AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goodman NF,
|
||
Cobin RH,
|
||
Futterweit W,
|
||
Glueck JS,
|
||
Legro RS,
|
||
Carmina E;
|
||
American Association of Clinical Endocrinologists (AACE);
|
||
American College of Endocrinology (ACE);
|
||
Androgen Excess and PCOS Society (AES)</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2015 Nov;21(11):1291-300.
|
||
doi: 10.4158/EP15748.DSC.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26509855" target="_blank">26509855</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(ovarian%20dysgenesis%2011)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (29)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38637590">Polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stener-Victorin E,
|
||
Teede H,
|
||
Norman RJ,
|
||
Legro R,
|
||
Goodarzi MO,
|
||
Dokras A,
|
||
Laven J,
|
||
Hoeger K,
|
||
Piltonen TT</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2024 Apr 18;10(1):27.
|
||
doi: 10.1038/s41572-024-00511-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38637590" target="_blank">38637590</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35728697">Turner Syndrome and Fertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Viuff M,
|
||
Gravholt CH</span><br />
|
||
<span class="medgenPMjournal">Ann Endocrinol (Paris)</span>
|
||
2022 Aug;83(4):244-249.
|
||
Epub 2022 Jun 18
|
||
doi: 10.1016/j.ando.2022.06.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35728697" target="_blank">35728697</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33347618">Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tso LO,
|
||
Costello MF,
|
||
Albuquerque LET,
|
||
Andriolo RB,
|
||
Macedo CR</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2020 Dec 21;12(12):CD006105.
|
||
doi: 10.1002/14651858.CD006105.pub4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33347618" target="_blank">33347618</a><a href="/pmc/articles/PMC8171384" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26509855">AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Goodman NF,
|
||
Cobin RH,
|
||
Futterweit W,
|
||
Glueck JS,
|
||
Legro RS,
|
||
Carmina E;
|
||
American Association of Clinical Endocrinologists (AACE);
|
||
American College of Endocrinology (ACE);
|
||
Androgen Excess and PCOS Society (AES)</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2015 Nov;21(11):1291-300.
|
||
doi: 10.4158/EP15748.DSC.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26509855" target="_blank">26509855</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8950667">Pancreatic adenocarcinoma: epidemiology and genetics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flanders TY,
|
||
Foulkes WD</span><br />
|
||
<span class="medgenPMjournal">J Med Genet</span>
|
||
1996 Nov;33(11):889-98.
|
||
doi: 10.1136/jmg.33.11.889.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8950667" target="_blank">8950667</a><a href="/pmc/articles/PMC1050781" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ovarian%20dysgenesis%2011%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (279)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38637590">Polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stener-Victorin E,
|
||
Teede H,
|
||
Norman RJ,
|
||
Legro R,
|
||
Goodarzi MO,
|
||
Dokras A,
|
||
Laven J,
|
||
Hoeger K,
|
||
Piltonen TT</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2024 Apr 18;10(1):27.
|
||
doi: 10.1038/s41572-024-00511-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38637590" target="_blank">38637590</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38152131">Androgen excess: a hallmark of polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang K,
|
||
Li Y,
|
||
Chen Y</span><br />
|
||
<span class="medgenPMjournal">Front Endocrinol (Lausanne)</span>
|
||
2023;14:1273542.
|
||
Epub 2023 Dec 13
|
||
doi: 10.3389/fendo.2023.1273542.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38152131" target="_blank">38152131</a><a href="/pmc/articles/PMC10751361" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36759093">Polycystic Ovarian Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Shrivastava S,
|
||
Conigliaro RL</span><br />
|
||
<span class="medgenPMjournal">Med Clin North Am</span>
|
||
2023 Mar;107(2):227-234.
|
||
Epub 2022 Dec 26
|
||
doi: 10.1016/j.mcna.2022.10.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36759093" target="_blank">36759093</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36190593">A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siddiqui S,
|
||
Mateen S,
|
||
Ahmad R,
|
||
Moin S</span><br />
|
||
<span class="medgenPMjournal">J Assist Reprod Genet</span>
|
||
2022 Nov;39(11):2439-2473.
|
||
Epub 2022 Oct 3
|
||
doi: 10.1007/s10815-022-02625-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36190593" target="_blank">36190593</a><a href="/pmc/articles/PMC9723082" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30616916">Polycystic ovary syndrome in adult women.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ortiz-Flores AE,
|
||
Luque-Ramírez M,
|
||
Escobar-Morreale HF</span><br />
|
||
<span class="medgenPMjournal">Med Clin (Barc)</span>
|
||
2019 Jun 7;152(11):450-457.
|
||
Epub 2019 Jan 4
|
||
doi: 10.1016/j.medcli.2018.11.019.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30616916" target="_blank">30616916</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ovarian%20dysgenesis%2011%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (279)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38870290">Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu Y,
|
||
Jiang JJ,
|
||
Du SY,
|
||
Mu LS,
|
||
Fan JJ,
|
||
Hu JC,
|
||
Ye Y,
|
||
Ding M,
|
||
Zhou WY,
|
||
Yu QH,
|
||
Xia YF,
|
||
Xu HY,
|
||
Shi YJ,
|
||
Qian SW,
|
||
Tang Y,
|
||
Li W,
|
||
Dang YJ,
|
||
Dong X,
|
||
Li XY,
|
||
Xu CJ,
|
||
Tang QQ</span><br />
|
||
<span class="medgenPMjournal">Science</span>
|
||
2024 Jun 14;384(6701):eadk5382.
|
||
doi: 10.1126/science.adk5382.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38870290" target="_blank">38870290</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36190593">A brief insight into the etiology, genetics, and immunology of polycystic ovarian syndrome (PCOS).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siddiqui S,
|
||
Mateen S,
|
||
Ahmad R,
|
||
Moin S</span><br />
|
||
<span class="medgenPMjournal">J Assist Reprod Genet</span>
|
||
2022 Nov;39(11):2439-2473.
|
||
Epub 2022 Oct 3
|
||
doi: 10.1007/s10815-022-02625-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36190593" target="_blank">36190593</a><a href="/pmc/articles/PMC9723082" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35728697">Turner Syndrome and Fertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Viuff M,
|
||
Gravholt CH</span><br />
|
||
<span class="medgenPMjournal">Ann Endocrinol (Paris)</span>
|
||
2022 Aug;83(4):244-249.
|
||
Epub 2022 Jun 18
|
||
doi: 10.1016/j.ando.2022.06.001.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35728697" target="_blank">35728697</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33347618">Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tso LO,
|
||
Costello MF,
|
||
Albuquerque LET,
|
||
Andriolo RB,
|
||
Macedo CR</span><br />
|
||
<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
|
||
2020 Dec 21;12(12):CD006105.
|
||
doi: 10.1002/14651858.CD006105.pub4.
|
||
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<div class="nl"><a target="_blank" href="/pubmed/26509855">AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Goodman NF,
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Cobin RH,
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Futterweit W,
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Glueck JS,
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Legro RS,
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Carmina E;
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American Association of Clinical Endocrinologists (AACE);
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American College of Endocrinology (ACE);
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Androgen Excess and PCOS Society (AES)</span><br />
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<span class="medgenPMjournal">Endocr Pract</span>
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2015 Nov;21(11):1291-300.
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<span class="bold">PMID: </span><a href="/pubmed/26509855" target="_blank">26509855</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ovarian%20dysgenesis%2011%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (119)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35728697">Turner Syndrome and Fertility.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Viuff M,
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<div class="nl"><a target="_blank" href="/pubmed/26509855">AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Goodman NF,
|
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Cobin RH,
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Futterweit W,
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Glueck JS,
|
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Legro RS,
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Carmina E;
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American Association of Clinical Endocrinologists (AACE);
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American College of Endocrinology (ACE);
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Androgen Excess and PCOS Society (AES)</span><br />
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<span class="medgenPMjournal">Endocr Pract</span>
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2015 Nov;21(11):1291-300.
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<span class="bold">PMID: </span><a href="/pubmed/26509855" target="_blank">26509855</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ovarian%20dysgenesis%2011%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (108)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/26509855">AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS, AMERICAN COLLEGE OF ENDOCRINOLOGY, AND ANDROGEN EXCESS AND PCOS SOCIETY DISEASE STATE CLINICAL REVIEW: GUIDE TO THE BEST PRACTICES IN THE EVALUATION AND TREATMENT OF POLYCYSTIC OVARY SYNDROME--PART 1.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Goodman NF,
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Cobin RH,
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Futterweit W,
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Glueck JS,
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Legro RS,
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Carmina E;
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American Association of Clinical Endocrinologists (AACE);
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American College of Endocrinology (ACE);
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Androgen Excess and PCOS Society (AES)</span><br />
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<span class="medgenPMjournal">Endocr Pract</span>
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2015 Nov;21(11):1291-300.
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doi: 10.4158/EP15748.DSC.
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<span class="bold">PMID: </span><a href="/pubmed/26509855" target="_blank">26509855</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/22699864">Ileostomy-associated chronic papillomatous dermatitis showing nevus sebaceous-like hyperplasia, HPV 16 infection, and lymphedema: a case report and literature review of ostomy-associated reactive epidermal hyperplasias.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ovarian%20dysgenesis%2011%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (168)</a></div></div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/36823415">Anatomical variations, treatment and outcomes of Herlyn-Werner-Wunderlich syndrome: a literature review of 1673 cases.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Liu Y,
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Li Z,
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Dou Y,
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Wang J,
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Li Y</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/36823415" target="_blank">36823415</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35675999">Anti-Müllerian hormone levels in the diagnosis of adolescent polycystic ovarian syndrome: a systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tsukui Y,
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Kitahara Y,
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Hasegawa Y,
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Kobayashi M,
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Osuka S,
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Iwase A</span><br />
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Epub 2022 Jun 8
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<span class="bold">PMID: </span><a href="/pubmed/35675999" target="_blank">35675999</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33347618">Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tso LO,
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Costello MF,
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Albuquerque LET,
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Andriolo RB,
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Macedo CR</span><br />
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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<span class="bold">PMID: </span><a href="/pubmed/33347618" target="_blank">33347618</a><a href="/pmc/articles/PMC8171384" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/31918426">Turner Syndrome Systematic Review: Spontaneous Thelarche and Menarche Stratified by Karyotype.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Dabrowski E,
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Jensen R,
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Johnson EK,
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Habiby RL,
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Brickman WJ,
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Finlayson C</span><br />
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<span class="medgenPMjournal">Horm Res Paediatr</span>
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2019;92(3):143-149.
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Epub 2020 Jan 9
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doi: 10.1159/000502902.
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<span class="bold">PMID: </span><a href="/pubmed/31918426" target="_blank">31918426</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27484228">Ovarian Stimulation, Intrauterine Insemination, Multiple Pregnancy and Major Congenital Malformations: A Systematic Review and Meta- Analysis- The ART_Rev Study.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Chaabane S,
|
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Sheehy O,
|
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Monnier P,
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Fraser W,
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Bissonnette F,
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Trasler JM,
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Muanda FT,
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Boukhris T,
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Karam F,
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Santos F,
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Blais L,
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<span class="medgenPMjournal">Curr Drug Saf</span>
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2016;11(3):222-61.
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<span class="bold">PMID: </span><a href="/pubmed/27484228" target="_blank">27484228</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ovarian%20dysgenesis%2011%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div></div>
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