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<meta name="keywords" content="C5394068, calm3, disease or syndrome, long qt syndrome 16, lqt16, ventricular tachycardia, catecholaminergic polymorphic 6, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="LQT16 Long QT syndrome-16 (LQT16) is characterized by a markedly prolonged corrected QT (QTc) interval and 2:1 atrioventricular (AV) block, with onset in the perinatal period. Patients experience bradycardia or ventricular tachyarrhythmias that may result in syncope, cardiac arrest, and/or sudden death (Reed et al., 2015; Wren et al., 2019). Patients with LQT14 (616247), LQT15 (616249), or LQT16, resulting from mutation in calmodulin genes CALM1 (114180), CALM2 (114182), or CALM3, respectively, typically have a more severe phenotype, with earlier onset, profound QT prolongation, and a high predilection for cardiac arrest and sudden death, than patients with mutations in other genes (Boczek et al., 2016). CPVT6 Catecholaminergic polymorphic ventricular tachycardia-6 (CPVT6) is characterized by childhood-onset syncopal episodes with exercise or stress. Electrocardiogram (ECG) shows a normal QT interval with a prominent U wave, and stress testing reveals premature ventricular contractions (PVCs) that may occur as bigeminy or couplets, and nonsustained ventricular tachycardia (Gomez-Hurtado et al., 2016)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=1713991
|
||
ConceptID=C5394068
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Long QT syndrome 16<span class="h1sub">(LQT16)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1713991</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C5394068</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>LONG QT SYNDROME 16; LQT16</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="CALM3 - ID: 808 - NCBI Gene" href="/gene/808" class="medgenPMinfo">CALM3</a> (19q13.32)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0032915" target="_blank">MONDO:0032915</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/618782" target="_blank">618782</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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||
<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">LQT16 Long QT syndrome-16 (LQT16) is characterized by a markedly prolonged corrected QT (QTc) interval and 2:1 atrioventricular (AV) block, with onset in the perinatal period. Patients experience bradycardia or ventricular tachyarrhythmias that may result in syncope, cardiac arrest, and/or sudden death (Reed et al., 2015; Wren et al., 2019). Patients with LQT14 (616247), LQT15 (616249), or LQT16, resulting from mutation in calmodulin genes CALM1 (114180), CALM2 (114182), or CALM3, respectively, typically have a more severe phenotype, with earlier onset, profound QT prolongation, and a high predilection for cardiac arrest and sudden death, than patients with mutations in other genes (Boczek et al., 2016). CPVT6 Catecholaminergic polymorphic ventricular tachycardia-6 (CPVT6) is characterized by childhood-onset syncopal episodes with exercise or stress. Electrocardiogram (ECG) shows a normal QT interval with a prominent U wave, and stress testing reveals premature ventricular contractions (PVCs) that may occur as bigeminy or couplets, and nonsustained ventricular tachycardia (Gomez-Hurtado et al., 2016). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_75546"><div><strong>Second degree atrioventricular block</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>75546</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0264906</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An intermittent atrioventricular block with failure of some atrial impulses to conduct to the ventricles, i.e., some but not all atrial impulses are conducted through the atrioventricular node and trigger ventricular contraction.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/75546">Feature record</a> | <a href="/medgen?term=%22Second%20degree%20atrioventricular%20block%22%5BClinical%20Features%5D%20OR%2075546%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_87490"><div><strong>Perimembranous ventricular septal defect</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>87490</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0344925</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A ventricular septal defect that is confluent with and involves the membranous septum and is bordered by an atrioventricular valve, not including the type 3 VSDs.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/87490">Feature record</a> | <a href="/medgen?term=%22Perimembranous%20ventricular%20septal%20defect%22%5BClinical%20Features%5D%20OR%2087490%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_140901"><div><strong>Bradycardia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>140901</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0428977</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A slower than normal heart rate (in adults, slower than 60 beats per minute).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/140901">Feature record</a> | <a href="/medgen?term=%22Bradycardia%22%5BClinical%20Features%5D%20OR%20140901%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_294666"><div><strong>Prolonged QTc interval</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>294666</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1560305</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A longer than normal interval (corrected for heart rate) between the Q and T waves in the heart's cycle. Prolonged QTc can cause premature action potentials during late phase depolarizations thereby leading to ventricular arrhythmias and ventricular fibrillations.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/294666">Feature record</a> | <a href="/medgen?term=%22Prolonged%20QTc%20interval%22%5BClinical%20Features%5D%20OR%20294666%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_745313"><div><strong>T-wave alternans</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>745313</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1998313</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A periodic beat-to-beat variation in the amplitude or shape of the T wave in an EKG.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/745313">Feature record</a> | <a href="/medgen?term=%22T-wave%20alternans%22%5BClinical%20Features%5D%20OR%20745313%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_868839"><div><strong>Patent ductus arteriosus after birth at term</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>868839</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4023249</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal persistent patency of the ductus arteriosus in postnatal life when birth was at 37 completed weeks of gestation or greater.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/868839">Feature record</a> | <a href="/medgen?term=%22Patent%20ductus%20arteriosus%20after%20birth%20at%20term%22%5BClinical%20Features%5D%20OR%20868839%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_140901" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bradycardia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_868839" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Patent ductus arteriosus after birth at term</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_87490" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Perimembranous ventricular septal defect</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_294666" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Prolonged QTc interval</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_75546" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Second degree atrioventricular block</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_745313" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">T-wave alternans</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/19926015">The RYR2-encoded ryanodine receptor/calcium release channel in patients diagnosed previously with either catecholaminergic polymorphic ventricular tachycardia or genotype negative, exercise-induced long QT syndrome: a comprehensive open reading frame mutational analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Medeiros-Domingo A,
|
||
Bhuiyan ZA,
|
||
Tester DJ,
|
||
Hofman N,
|
||
Bikker H,
|
||
van Tintelen JP,
|
||
Mannens MM,
|
||
Wilde AA,
|
||
Ackerman MJ</span><br />
|
||
<span class="medgenPMjournal">J Am Coll Cardiol</span>
|
||
2009 Nov 24;54(22):2065-74.
|
||
doi: 10.1016/j.jacc.2009.08.022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19926015" target="_blank">19926015</a><a href="/pmc/articles/PMC2880864" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17194624">Guidelines for the diagnosis and management of familial long QT syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Skinner JR;
|
||
CSANZ Cardiovascular Genetics Working Group</span><br />
|
||
<span class="medgenPMjournal">Heart Lung Circ</span>
|
||
2007 Feb;16(1):22-4.
|
||
Epub 2006 Dec 27
|
||
doi: 10.1016/j.hlc.2006.10.021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17194624" target="_blank">17194624</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15840476">Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tester DJ,
|
||
Will ML,
|
||
Haglund CM,
|
||
Ackerman MJ</span><br />
|
||
<span class="medgenPMjournal">Heart Rhythm</span>
|
||
2005 May;2(5):507-17.
|
||
doi: 10.1016/j.hrthm.2005.01.020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15840476" target="_blank">15840476</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(long%20qt%20syndrome%2016)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (64)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23716032">Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tisdale JE,
|
||
Jaynes HA,
|
||
Kingery JR,
|
||
Mourad NA,
|
||
Trujillo TN,
|
||
Overholser BR,
|
||
Kovacs RJ</span><br />
|
||
<span class="medgenPMjournal">Circ Cardiovasc Qual Outcomes</span>
|
||
2013 Jul;6(4):479-87.
|
||
Epub 2013 May 28
|
||
doi: 10.1161/CIRCOUTCOMES.113.000152.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23716032" target="_blank">23716032</a><a href="/pmc/articles/PMC3788679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22420530">Evaluation of cardiac manifestations in pediatric liver transplant candidates.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Madan N,
|
||
Arnon R,
|
||
Arnon R</span><br />
|
||
<span class="medgenPMjournal">Pediatr Transplant</span>
|
||
2012 Jun;16(4):318-28.
|
||
Epub 2012 Mar 16
|
||
doi: 10.1111/j.1399-3046.2012.01667.x.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22420530" target="_blank">22420530</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17194624">Guidelines for the diagnosis and management of familial long QT syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Skinner JR;
|
||
CSANZ Cardiovascular Genetics Working Group</span><br />
|
||
<span class="medgenPMjournal">Heart Lung Circ</span>
|
||
2007 Feb;16(1):22-4.
|
||
Epub 2006 Dec 27
|
||
doi: 10.1016/j.hlc.2006.10.021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17194624" target="_blank">17194624</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11598867">Pediatric arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hanisch D</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Nurs</span>
|
||
2001 Oct;16(5):351-62.
|
||
doi: 10.1053/jpdn.2001.26571.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11598867" target="_blank">11598867</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2016%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (577)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29394346">QTc in the elderly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandenbriele C,
|
||
Price S</span><br />
|
||
<span class="medgenPMjournal">Eur Heart J</span>
|
||
2018 Apr 21;39(16):1445.
|
||
doi: 10.1093/eurheartj/ehy015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29394346" target="_blank">29394346</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25367822">Systematic review of the electrocardiographic changes in the takotsubo syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duran-Cambra A,
|
||
Sutil-Vega M,
|
||
Fiol M,
|
||
Núñez-Gil IJ,
|
||
Vila M,
|
||
Sans-Roselló J,
|
||
Cinca J,
|
||
Sionis A</span><br />
|
||
<span class="medgenPMjournal">Ann Noninvasive Electrocardiol</span>
|
||
2015 Jan;20(1):1-6.
|
||
Epub 2014 Nov 4
|
||
doi: 10.1111/anec.12228.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25367822" target="_blank">25367822</a><a href="/pmc/articles/PMC6931802" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12709446">Long QT Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moss AJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2003 Apr 23-30;289(16):2041-4.
|
||
doi: 10.1001/jama.289.16.2041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12709446" target="_blank">12709446</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11271945">The long QT syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Priori SG,
|
||
Bloise R,
|
||
Crotti L</span><br />
|
||
<span class="medgenPMjournal">Europace</span>
|
||
2001 Jan;3(1):16-27.
|
||
doi: 10.1053/eupc.2000.0141.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11271945" target="_blank">11271945</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2016%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (442)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12709446">Long QT Syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moss AJ</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2003 Apr 23-30;289(16):2041-4.
|
||
doi: 10.1001/jama.289.16.2041.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12709446" target="_blank">12709446</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11598867">Pediatric arrhythmias.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hanisch D</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Nurs</span>
|
||
2001 Oct;16(5):351-62.
|
||
doi: 10.1053/jpdn.2001.26571.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11598867" target="_blank">11598867</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11271945">The long QT syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Priori SG,
|
||
Bloise R,
|
||
Crotti L</span><br />
|
||
<span class="medgenPMjournal">Europace</span>
|
||
2001 Jan;3(1):16-27.
|
||
doi: 10.1053/eupc.2000.0141.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11271945" target="_blank">11271945</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/7902224">Torsade de pointes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roden DM</span><br />
|
||
<span class="medgenPMjournal">Clin Cardiol</span>
|
||
1993 Sep;16(9):683-6.
|
||
doi: 10.1002/clc.4960160910.
|
||
<span class="bold">PMID: </span><a href="/pubmed/7902224" target="_blank">7902224</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2016%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (354)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37409478">DiscoVari: A Web-Based Precision Medicine Tool for Predicting Variant Pathogenicity in Cardiomyopathy- and Channelopathy-Associated Genes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kurzlechner LM,
|
||
Kishnani S,
|
||
Chowdhury S,
|
||
Atkins SL,
|
||
Moya-Mendez ME,
|
||
Parker LE,
|
||
Rosamilia MB,
|
||
Tadros HJ,
|
||
Pace LA,
|
||
Patel V,
|
||
Chahal CAA,
|
||
Landstrom AP</span><br />
|
||
<span class="medgenPMjournal">Circ Genom Precis Med</span>
|
||
2023 Aug;16(4):317-327.
|
||
Epub 2023 Jul 6
|
||
doi: 10.1161/CIRCGEN.122.003911.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37409478" target="_blank">37409478</a><a href="/pmc/articles/PMC10527712" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32250059">Exposure-Response Analysis to Assess the Concentration-QTc Relationship of Psilocybin/Psilocin.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dahmane E,
|
||
Hutson PR,
|
||
Gobburu JVS</span><br />
|
||
<span class="medgenPMjournal">Clin Pharmacol Drug Dev</span>
|
||
2021 Jan;10(1):78-85.
|
||
Epub 2020 Apr 6
|
||
doi: 10.1002/cpdd.796.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32250059" target="_blank">32250059</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32144177">A Review of Long QT Syndrome: Everything a Hospitalist Should Know.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sharma N,
|
||
Cortez D,
|
||
Disori K,
|
||
Imundo JR,
|
||
Beck M</span><br />
|
||
<span class="medgenPMjournal">Hosp Pediatr</span>
|
||
2020 Apr;10(4):369-375.
|
||
Epub 2020 Mar 6
|
||
doi: 10.1542/hpeds.2019-0139.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32144177" target="_blank">32144177</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23716032">Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tisdale JE,
|
||
Jaynes HA,
|
||
Kingery JR,
|
||
Mourad NA,
|
||
Trujillo TN,
|
||
Overholser BR,
|
||
Kovacs RJ</span><br />
|
||
<span class="medgenPMjournal">Circ Cardiovasc Qual Outcomes</span>
|
||
2013 Jul;6(4):479-87.
|
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Epub 2013 May 28
|
||
doi: 10.1161/CIRCOUTCOMES.113.000152.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23716032" target="_blank">23716032</a><a href="/pmc/articles/PMC3788679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9080858">Update on MADIT: the Multicenter Automatic Defibrillator Implantation Trial. The long QT interval syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Moss AJ</span><br />
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<span class="medgenPMjournal">Am J Cardiol</span>
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1997 Mar 20;79(6A):16-9.
|
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doi: 10.1016/s0002-9149(97)00116-1.
|
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<span class="bold">PMID: </span><a href="/pubmed/9080858" target="_blank">9080858</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2016%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (287)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37071726">Elucidation of ALG10B as a Novel Long-QT Syndrome-Susceptibility Gene.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Zhou W,
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Ye D,
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Tester DJ,
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Bains S,
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Giudicessi JR,
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Haglund-Turnquist CM,
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Orland KM,
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January CT,
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Eckhardt LL,
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Maginot KR,
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Ackerman MJ</span><br />
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<span class="medgenPMjournal">Circ Genom Precis Med</span>
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2023 Apr;16(2):e003726.
|
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Epub 2023 Feb 22
|
||
doi: 10.1161/CIRCGEN.122.003726.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37071726" target="_blank">37071726</a><a href="/pmc/articles/PMC10844923" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
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Vandenberk B,
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Vandenberghe J,
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Willems R,
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Foulon V</span><br />
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<span class="medgenPMjournal">Int J Clin Pharm</span>
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2017 Feb;39(1):16-25.
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Epub 2016 Dec 23
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doi: 10.1007/s11096-016-0414-2.
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<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
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||
<div class="nl"><a target="_blank" href="/pubmed/23716032">Development and validation of a risk score to predict QT interval prolongation in hospitalized patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tisdale JE,
|
||
Jaynes HA,
|
||
Kingery JR,
|
||
Mourad NA,
|
||
Trujillo TN,
|
||
Overholser BR,
|
||
Kovacs RJ</span><br />
|
||
<span class="medgenPMjournal">Circ Cardiovasc Qual Outcomes</span>
|
||
2013 Jul;6(4):479-87.
|
||
Epub 2013 May 28
|
||
doi: 10.1161/CIRCOUTCOMES.113.000152.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23716032" target="_blank">23716032</a><a href="/pmc/articles/PMC3788679" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15840476">Compendium of cardiac channel mutations in 541 consecutive unrelated patients referred for long QT syndrome genetic testing.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tester DJ,
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Will ML,
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Haglund CM,
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Ackerman MJ</span><br />
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<span class="medgenPMjournal">Heart Rhythm</span>
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2005 May;2(5):507-17.
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doi: 10.1016/j.hrthm.2005.01.020.
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<span class="bold">PMID: </span><a href="/pubmed/15840476" target="_blank">15840476</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12402413">Neonatal lupus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Brucato A,
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Cimaz R,
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Stramba-Badiale M</span><br />
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<span class="medgenPMjournal">Clin Rev Allergy Immunol</span>
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2002 Dec;23(3):279-99.
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doi: 10.1385/CRIAI:23:3:279.
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<span class="bold">PMID: </span><a href="/pubmed/12402413" target="_blank">12402413</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2016%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (315)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37850595">Life-threatening cardiac arrhythmia and sudden death during electronic gaming: An international case series and systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lawley CM,
|
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Tester M,
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Sanatani S,
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||
Prendiville T,
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Beach CM,
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||
Vinocur JM,
|
||
Horie M,
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||
Uhm JS,
|
||
Khongphatthanayothin A,
|
||
Ayers MD,
|
||
Starling L,
|
||
Yoshida Y,
|
||
Shah MJ,
|
||
Skinner JR,
|
||
Turner C</span><br />
|
||
<span class="medgenPMjournal">Heart Rhythm</span>
|
||
2022 Nov;19(11):1826-1833.
|
||
Epub 2022 Oct 11
|
||
doi: 10.1016/j.hrthm.2022.08.003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37850595" target="_blank">37850595</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35861842">Utility of Provocative Testing in the Diagnosis and Genotyping of Congenital Long QT Syndrome: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang Y,
|
||
Lv TT,
|
||
Li SY,
|
||
Liu P,
|
||
Gao QG,
|
||
Zhang P</span><br />
|
||
<span class="medgenPMjournal">J Am Heart Assoc</span>
|
||
2022 Jul 19;11(14):e025246.
|
||
Epub 2022 Jul 8
|
||
doi: 10.1161/JAHA.122.025246.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35861842" target="_blank">35861842</a><a href="/pmc/articles/PMC9707831" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29380395">Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang N,
|
||
Gong M,
|
||
Tse G,
|
||
Zhang Z,
|
||
Meng L,
|
||
Yan BP,
|
||
Zhang L,
|
||
Wu G,
|
||
Xia Y,
|
||
Xin-Yan G,
|
||
Li G,
|
||
Liu T</span><br />
|
||
<span class="medgenPMjournal">Pacing Clin Electrophysiol</span>
|
||
2018 Mar;41(3):321-327.
|
||
Epub 2018 Feb 16
|
||
doi: 10.1111/pace.13292.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29380395" target="_blank">29380395</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28012118">Risk factors for QTc-prolongation: systematic review of the evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Vandael E,
|
||
Vandenberk B,
|
||
Vandenberghe J,
|
||
Willems R,
|
||
Foulon V</span><br />
|
||
<span class="medgenPMjournal">Int J Clin Pharm</span>
|
||
2017 Feb;39(1):16-25.
|
||
Epub 2016 Dec 23
|
||
doi: 10.1007/s11096-016-0414-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28012118" target="_blank">28012118</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25367822">Systematic review of the electrocardiographic changes in the takotsubo syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Duran-Cambra A,
|
||
Sutil-Vega M,
|
||
Fiol M,
|
||
Núñez-Gil IJ,
|
||
Vila M,
|
||
Sans-Roselló J,
|
||
Cinca J,
|
||
Sionis A</span><br />
|
||
<span class="medgenPMjournal">Ann Noninvasive Electrocardiol</span>
|
||
2015 Jan;20(1):1-6.
|
||
Epub 2014 Nov 4
|
||
doi: 10.1111/anec.12228.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25367822" target="_blank">25367822</a><a href="/pmc/articles/PMC6931802" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Long%20QT%20syndrome%2016%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (10)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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|
||
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||
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|
||
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|
||
|
||
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|
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</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C5394068%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (13)</a></li>
|
||
<li><a href="/gtr/tests?term=C5394068%5bDISCUI%5d&filter=method%3A2%5F29" target="_blank">Detection of homozygosity (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C5394068%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C5394068%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (12)</a></li>
|
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<li><a href="/gtr/tests?term=C5394068%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (5)</a></li>
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||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C5394068%5bDISCUI%5d" target="_blank">See all (13)</a></total></li>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=618782" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Long%20QT%20syndrome%2016" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(long%20qt%20syndrome%2016)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=114183" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=808[geneid]" target="_blank">View CALM3 variations in ClinVar</a></li><li><a href="https://catalog.coriell.org/Search?q=618782" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/long_qt_syndrome_16" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Long%20QT%20syndrome%2016" target="_blank">MedlinePlus</a></li></ul></div>
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<h3>Reviews</h3>
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<li>
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<a href="/pubmed/20301308" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=3" target="_blank"><span class="gene_reviews">GeneReviews</span></a>
|
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<li>
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<a href="/pubmed/clinical?term=Long%20QT%20syndrome%2016" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=3" target="_blank">PubMed Clinical Queries</a>
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<li>
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<a href="/pubmed?term=Long%20QT%20syndrome%2016%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=3&linkpostotal=3" target="_blank">Reviews in PubMed</a>
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</li>
|
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</div>
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<div class="portlet_head">
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<div class="portlet_title">
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<h3>Related information</h3>
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||
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<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=1713991" ref="log$=recordlinks">ClinVar</a>
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