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<meta name="keywords" content="C5394062, chtd7, congenital abnormality, congenital heart defects, multiple types, 7, flt4, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Multiple types of congenital heart defects-7 (CHTD7) is an autosomal dominant disorder with incomplete penetrance characterized mainly by tetralogy of Fallot but also including right-sided aortic arch, absent pulmonary valve, and other cardiac abnormalities (Jin et al., 2017, Reuter et al., 2019)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=1714491
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ConceptID=C5394062
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Congenital heart defects, multiple types, 7<span class="h1sub">(CHTD7)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1714491</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C5394062</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>CHTD7; CONGENITAL HEART DEFECTS, MULTIPLE TYPES, 7</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="FLT4 - ID: 2324 - NCBI Gene" href="/gene/2324" class="medgenPMinfo">FLT4</a> (5q35.3)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0032913" target="_blank">MONDO:0032913</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/618780" target="_blank">618780</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Multiple types of congenital heart defects-7 (CHTD7) is an autosomal dominant disorder with incomplete penetrance characterized mainly by tetralogy of Fallot but also including right-sided aortic arch, absent pulmonary valve, and other cardiac abnormalities (Jin et al., 2017, Reuter et al., 2019). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
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</div>
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<div class="portlet mgSection" id="ID_102">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_48474"><div><strong>Right aortic arch</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>48474</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0035615</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Aorta descends on right instead of on the left.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/48474">Feature record</a> | <a href="/medgen?term=%22Right%20aortic%20arch%22%5BClinical%20Features%5D%20OR%2048474%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_21498"><div><strong>Tetralogy of Fallot</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>21498</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0039685</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Each of the heart defects associated with CCHD affects the flow of blood into, out of, or through the heart. Some of the heart defects involve structures within the heart itself, such as the two lower chambers of the heart (the ventricles) or the valves that control blood flow through the heart. Others affect the structure of the large blood vessels leading into and out of the heart (including the aorta and pulmonary artery). Still others involve a combination of these structural abnormalities.\n\nSome people with treated CCHD have few related health problems later in life. However, long-term effects of CCHD can include delayed development and reduced stamina during exercise. Adults with these heart defects have an increased risk of abnormal heart rhythms, heart failure, sudden cardiac arrest, stroke, and premature death.\n\nPeople with CCHD have one or more specific heart defects. The heart defects classified as CCHD include coarctation of the aorta, double-outlet right ventricle, D-transposition of the great arteries, Ebstein anomaly, hypoplastic left heart syndrome, interrupted aortic arch, pulmonary atresia with intact septum, single ventricle, total anomalous pulmonary venous connection, tetralogy of Fallot, tricuspid atresia, and truncus arteriosus.\n\nAlthough babies with CCHD may appear healthy for the first few hours or days of life, signs and symptoms soon become apparent. These can include an abnormal heart sound during a heartbeat (heart murmur), rapid breathing (tachypnea), low blood pressure (hypotension), low levels of oxygen in the blood (hypoxemia), and a blue or purple tint to the skin caused by a shortage of oxygen (cyanosis). If untreated, CCHD can lead to shock, coma, and death. However, most people with CCHD now survive past infancy due to improvements in early detection, diagnosis, and treatment.\n\nCritical congenital heart disease (CCHD) is a term that refers to a group of serious heart defects that are present from birth. These abnormalities result from problems with the formation of one or more parts of the heart during the early stages of embryonic development. CCHD prevents the heart from pumping blood effectively or reduces the amount of oxygen in the blood. As a result, organs and tissues throughout the body do not receive enough oxygen, which can lead to organ damage and life-threatening complications. Individuals with CCHD usually require surgery soon after birth.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/21498">Feature record</a> | <a href="/medgen?term=%22Tetralogy%20of%20Fallot%22%5BClinical%20Features%5D%20OR%2021498%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_78575"><div><strong>Absence of the pulmonary valve</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>78575</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265831</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Refers to the specific combination of defects with a severely dysplastic pulmonary valve and massively dilated branch pulmonary arteries.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/78575">Feature record</a> | <a href="/medgen?term=%22Absence%20of%20the%20pulmonary%20valve%22%5BClinical%20Features%5D%20OR%2078575%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_488819"><div><strong>Double aortic arch</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>488819</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265883</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A conenital abnormality of the aortic arch in which the two embryonic aortc arches form a vascular ring that surrounds the trachea or esophagus and then join to form the descending aorta. Double aortic arch can cause symptoms because of compression of the esophagus (dysphagia, cyanosis while eating) or trachea (stridor).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/488819">Feature record</a> | <a href="/medgen?term=%22Double%20aortic%20arch%22%5BClinical%20Features%5D%20OR%20488819%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_82723"><div><strong>Pulmonary artery atresia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>82723</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0265908</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A congenital anomaly with a narrowing or complete absence of the opening between the right ventricle and the pulmonary artery.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/82723">Feature record</a> | <a href="/medgen?term=%22Pulmonary%20artery%20atresia%22%5BClinical%20Features%5D%20OR%2082723%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_408291"><div><strong>Pulmonic stenosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>408291</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1956257</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A narrowing of the right ventricular outflow tract that can occur at the pulmonary valve (valvular stenosis), below the pulmonary valve (infundibular stenosis), or above the pulmonary valve (supravalvar stenosis).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/408291">Feature record</a> | <a href="/medgen?term=%22Pulmonic%20stenosis%22%5BClinical%20Features%5D%20OR%20408291%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1633176"><div><strong>Aortopulmonary collateral arteries</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1633176</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4703564</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1633176">Feature record</a> | <a href="/medgen?term=%22Aortopulmonary%20collateral%20arteries%22%5BClinical%20Features%5D%20OR%201633176%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1613"><div><strong>Anxiety</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1613</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0003467</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Intense feelings of nervousness, tension, or panic often arise in response to interpersonal stresses. There is worry about the negative effects of past unpleasant experiences and future negative possibilities. Individuals may feel fearful, apprehensive, or threatened by uncertainty, and they may also have fears of falling apart or losing control.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1613">Feature record</a> | <a href="/medgen?term=%22Anxiety%22%5BClinical%20Features%5D%20OR%201613%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_4229"><div><strong>Depression</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>4229</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0011581</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Mental or Behavioral Dysfunction</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Frequently experiencing feelings of being down, miserable, and/or hopeless; struggling to recover from these moods; having a pessimistic outlook on the future; feeling a pervasive sense of shame; having a low self-worth; experiencing thoughts of suicide and engaging in suicidal behavior.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/4229">Feature record</a> | <a href="/medgen?term=%22Depression%22%5BClinical%20Features%5D%20OR%204229%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of the cardiovascular system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_78575" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Absence of the pulmonary valve</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1633176" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Aortopulmonary collateral arteries</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_488819" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Double aortic arch</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_82723" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pulmonary artery atresia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_408291" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Pulmonic stenosis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_48474" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Right aortic arch</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_21498" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Tetralogy of Fallot</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1613" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anxiety</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_4229" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Depression</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39062575">Recent Advances in Hydrogel-Based 3D Bioprinting and Its Potential Application in the Treatment of Congenital Heart Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salih T,
|
||
Caputo M,
|
||
Ghorbel MT</span><br />
|
||
<span class="medgenPMjournal">Biomolecules</span>
|
||
2024 Jul 18;14(7)
|
||
doi: 10.3390/biom14070861.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39062575" target="_blank">39062575</a><a href="/pmc/articles/PMC11274841" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30079851">Improving maternal-infant bonding after prenatal diagnosis of CHD.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Barker PCA,
|
||
Tatum GH,
|
||
Campbell MJ,
|
||
Camitta MGW,
|
||
Milazzo AS,
|
||
Hornik CP,
|
||
French A,
|
||
Miller SG</span><br />
|
||
<span class="medgenPMjournal">Cardiol Young</span>
|
||
2018 Nov;28(11):1306-1315.
|
||
Epub 2018 Aug 6
|
||
doi: 10.1017/S104795111800121X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30079851" target="_blank">30079851</a><a href="/pmc/articles/PMC6197928" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29945508">Single Ventricle and Total Anomalous Pulmonary Venous Connection: Implications of Prenatal Diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hancock HS,
|
||
Romano JC,
|
||
Armstrong A,
|
||
Yu S,
|
||
Lowery R,
|
||
Gelehrter S</span><br />
|
||
<span class="medgenPMjournal">World J Pediatr Congenit Heart Surg</span>
|
||
2018 Jul;9(4):434-439.
|
||
doi: 10.1177/2150135118771344.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29945508" target="_blank">29945508</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(congenital%20heart%20defects%2C%20multiple%20types%2C%207)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (12)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35508600">CTA analysis of 482 cases of coronary artery fistula: A large-scale imaging study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cai R,
|
||
Ma X,
|
||
Zhao X,
|
||
Xu J,
|
||
Zhu L,
|
||
Ku L</span><br />
|
||
<span class="medgenPMjournal">J Card Surg</span>
|
||
2022 Jul;37(7):2172-2181.
|
||
Epub 2022 May 4
|
||
doi: 10.1111/jocs.16500.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35508600" target="_blank">35508600</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33683997">Updating an Empirically Based Tool for Analyzing Congenital Heart Surgery Mortality.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacobs ML,
|
||
Jacobs JP,
|
||
Thibault D,
|
||
Hill KD,
|
||
Anderson BR,
|
||
Eghtesady P,
|
||
Karamlou T,
|
||
Kumar SR,
|
||
Mayer JE,
|
||
Mery CM,
|
||
Nathan M,
|
||
Overman DM,
|
||
Pasquali SK,
|
||
St Louis JD,
|
||
Shahian D,
|
||
O'Brien SM</span><br />
|
||
<span class="medgenPMjournal">World J Pediatr Congenit Heart Surg</span>
|
||
2021 Mar;12(2):246-281.
|
||
doi: 10.1177/2150135121991528.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33683997" target="_blank">33683997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33238988">Clinical and epidemiological features of heart-hand syndrome, an updated analysis in China.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yin Y,
|
||
Ji J,
|
||
Zhao J,
|
||
Chen S,
|
||
Tian W</span><br />
|
||
<span class="medgenPMjournal">BMC Musculoskelet Disord</span>
|
||
2020 Nov 25;21(1):777.
|
||
doi: 10.1186/s12891-020-03813-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33238988" target="_blank">33238988</a><a href="/pmc/articles/PMC7690113" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30991346">Is there a role for autophagy in ascending aortopathy associated with tricuspid or bicuspid aortic valve?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Forte A,
|
||
Cipollaro M,
|
||
De Feo M,
|
||
Della Corte A</span><br />
|
||
<span class="medgenPMjournal">Clin Sci (Lond)</span>
|
||
2019 Apr 15;133(7):805-819.
|
||
Epub 2019 Apr 2
|
||
doi: 10.1042/CS20181092.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30991346" target="_blank">30991346</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23558868">Congenital heart defects in Kabuki syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yuan SM</span><br />
|
||
<span class="medgenPMjournal">Cardiol J</span>
|
||
2013;20(2):121-4.
|
||
doi: 10.5603/CJ.2013.0023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23558868" target="_blank">23558868</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20heart%20defects%2C%20multiple%20types%2C%207%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (66)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35179301">Co-occurring anomalies in congenital oral clefts.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stoll C,
|
||
Alembik Y,
|
||
Roth MP</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet A</span>
|
||
2022 Jun;188(6):1700-1715.
|
||
Epub 2022 Feb 18
|
||
doi: 10.1002/ajmg.a.62689.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35179301" target="_blank">35179301</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33881198">Co-occurring non-omphalocele and non-gastroschisis anomalies among cases with congenital omphalocele and gastroschisis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stoll C,
|
||
Alembik Y,
|
||
Roth MP</span><br />
|
||
<span class="medgenPMjournal">Am J Med Genet A</span>
|
||
2021 Jul;185(7):1954-1971.
|
||
Epub 2021 Apr 21
|
||
doi: 10.1002/ajmg.a.62112.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33881198" target="_blank">33881198</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28591192">Perinatal outcomes and congenital heart defect prognosis in 53313 non-selected perinatal infants.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie D,
|
||
Wang H,
|
||
Liu Z,
|
||
Fang J,
|
||
Yang T,
|
||
Zhou S,
|
||
Wang A,
|
||
Qin J,
|
||
Xiong L</span><br />
|
||
<span class="medgenPMjournal">PLoS One</span>
|
||
2017;12(6):e0177229.
|
||
Epub 2017 Jun 7
|
||
doi: 10.1371/journal.pone.0177229.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28591192" target="_blank">28591192</a><a href="/pmc/articles/PMC5462529" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25497206">Associated noncardiac congenital anomalies among cases with congenital heart defects.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stoll C,
|
||
Dott B,
|
||
Alembik Y,
|
||
Roth MP</span><br />
|
||
<span class="medgenPMjournal">Eur J Med Genet</span>
|
||
2015 Feb;58(2):75-85.
|
||
Epub 2014 Dec 12
|
||
doi: 10.1016/j.ejmg.2014.12.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25497206" target="_blank">25497206</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23558868">Congenital heart defects in Kabuki syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yuan SM</span><br />
|
||
<span class="medgenPMjournal">Cardiol J</span>
|
||
2013;20(2):121-4.
|
||
doi: 10.5603/CJ.2013.0023.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23558868" target="_blank">23558868</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20heart%20defects%2C%20multiple%20types%2C%207%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (54)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39062575">Recent Advances in Hydrogel-Based 3D Bioprinting and Its Potential Application in the Treatment of Congenital Heart Disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salih T,
|
||
Caputo M,
|
||
Ghorbel MT</span><br />
|
||
<span class="medgenPMjournal">Biomolecules</span>
|
||
2024 Jul 18;14(7)
|
||
doi: 10.3390/biom14070861.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39062575" target="_blank">39062575</a><a href="/pmc/articles/PMC11274841" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34857025">RASopathies and hemostatic abnormalities: key role of platelet dysfunction.</a></div>
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Marchetti V,
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Cirillo F,
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Di Minno A,
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Rosano C,
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Pagano S,
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Siano MA,
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Falco M,
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Assunto A,
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De Luca A,
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2021 Dec 2;16(1):499.
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<div class="portlet_content ln"><span class="medgenPMauthor">Yang L,
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Tai BC,
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Lawson C,
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Lupo PJ,
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Riehle-Colarusso TJ,
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Stewart PA,
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van Wijngaarden E,
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Correa A;
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20heart%20defects%2C%20multiple%20types%2C%207%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (21)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/36006061">Partial Anomalous Left Pulmonary Artery Anterior Versus Posterior Types: A Systematic Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Restrepo CS,
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Gonzalez TV,
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Baxi AJ,
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Saboo SS</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/36006061" target="_blank">36006061</a><a href="/pmc/articles/PMC9416361" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35508600">CTA analysis of 482 cases of coronary artery fistula: A large-scale imaging study.</a></div>
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Ma X,
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Zhao X,
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<span class="bold">PMID: </span><a href="/pubmed/35508600" target="_blank">35508600</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Forte A,
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Cipollaro M,
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De Feo M,
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Della Corte A</span><br />
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<span class="medgenPMjournal">Clin Sci (Lond)</span>
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2019 Apr 15;133(7):805-819.
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<span class="bold">PMID: </span><a href="/pubmed/30991346" target="_blank">30991346</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28591192">Perinatal outcomes and congenital heart defect prognosis in 53313 non-selected perinatal infants.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Xie D,
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Wang H,
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Liu Z,
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Fang J,
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Yang T,
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Zhou S,
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Wang A,
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Qin J,
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Xiong L</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/28591192" target="_blank">28591192</a><a href="/pmc/articles/PMC5462529" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
||
<div class="nl"><a target="_blank" href="/pubmed/23558868">Congenital heart defects in Kabuki syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yuan SM</span><br />
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<span class="medgenPMjournal">Cardiol J</span>
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<span class="bold">PMID: </span><a href="/pubmed/23558868" target="_blank">23558868</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20heart%20defects%2C%20multiple%20types%2C%207%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (37)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/38836834">Meta-regression of sulcal patterns, clinical and environmental factors on neurodevelopmental outcomes in participants with multiple CHD types.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Maleyeff L,
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Park HJ,
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Khazal ZSH,
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Wypij D,
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Rollins CK,
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Yun HJ,
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Bellinger DC,
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Watson CG,
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Roberts AE,
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Newburger JW,
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Grant PE,
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Im K,
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Morton SU</span><br />
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<span class="medgenPMjournal">Cereb Cortex</span>
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2024 Jun 4;34(6)
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doi: 10.1093/cercor/bhae224.
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<span class="bold">PMID: </span><a href="/pubmed/38836834" target="_blank">38836834</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37605817">Quality analysis of publicly available information about hypoplastic left heart syndrome.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Brennan Z,
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Sharaf OM,
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Treffalls JA,
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Roa-Vidal N,
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Weinstein DJ,
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Bassuk JS,
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Stukov Y,
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Peek GJ,
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Bleiweis MS,
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Jacobs JP</span><br />
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<span class="medgenPMjournal">Cardiol Young</span>
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2023 Jul;33(7):1079-1085.
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Epub 2023 Aug 22
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doi: 10.1017/S1047951123001294.
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||
<span class="bold">PMID: </span><a href="/pubmed/37605817" target="_blank">37605817</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34857025">RASopathies and hemostatic abnormalities: key role of platelet dysfunction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Di Candia F,
|
||
Marchetti V,
|
||
Cirillo F,
|
||
Di Minno A,
|
||
Rosano C,
|
||
Pagano S,
|
||
Siano MA,
|
||
Falco M,
|
||
Assunto A,
|
||
Boccia G,
|
||
Magliacane G,
|
||
Pinna V,
|
||
De Luca A,
|
||
Tartaglia M,
|
||
Di Minno G,
|
||
Strisciuglio P,
|
||
Melis D</span><br />
|
||
<span class="medgenPMjournal">Orphanet J Rare Dis</span>
|
||
2021 Dec 2;16(1):499.
|
||
doi: 10.1186/s13023-021-02122-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34857025" target="_blank">34857025</a><a href="/pmc/articles/PMC8638204" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33683997">Updating an Empirically Based Tool for Analyzing Congenital Heart Surgery Mortality.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacobs ML,
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Jacobs JP,
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Thibault D,
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Hill KD,
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Anderson BR,
|
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Eghtesady P,
|
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Karamlou T,
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Kumar SR,
|
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Mayer JE,
|
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Mery CM,
|
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Nathan M,
|
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Overman DM,
|
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Pasquali SK,
|
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St Louis JD,
|
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Shahian D,
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O'Brien SM</span><br />
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<span class="medgenPMjournal">World J Pediatr Congenit Heart Surg</span>
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||
2021 Mar;12(2):246-281.
|
||
doi: 10.1177/2150135121991528.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33683997" target="_blank">33683997</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21728077">The contribution of chromosomal abnormalities to congenital heart defects: a population-based study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hartman RJ,
|
||
Rasmussen SA,
|
||
Botto LD,
|
||
Riehle-Colarusso T,
|
||
Martin CL,
|
||
Cragan JD,
|
||
Shin M,
|
||
Correa A</span><br />
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<span class="medgenPMjournal">Pediatr Cardiol</span>
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||
2011 Dec;32(8):1147-57.
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Epub 2011 Jul 5
|
||
doi: 10.1007/s00246-011-0034-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21728077" target="_blank">21728077</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20heart%20defects%2C%20multiple%20types%2C%207%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (29)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36006061">Partial Anomalous Left Pulmonary Artery Anterior Versus Posterior Types: A Systematic Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Restrepo CS,
|
||
Gonzalez TV,
|
||
Baxi AJ,
|
||
Saboo SS</span><br />
|
||
<span class="medgenPMjournal">Tomography</span>
|
||
2022 Jul 27;8(4):1947-1958.
|
||
doi: 10.3390/tomography8040163.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36006061" target="_blank">36006061</a><a href="/pmc/articles/PMC9416361" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24773223">A systematic review on the efficacy and safety of transcatheter device closure of ventricular septal defects (VSD).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yang L,
|
||
Tai BC,
|
||
Khin LW,
|
||
Quek SC</span><br />
|
||
<span class="medgenPMjournal">J Interv Cardiol</span>
|
||
2014 Jun;27(3):260-72.
|
||
Epub 2014 Apr 29
|
||
doi: 10.1111/joic.12121.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24773223" target="_blank">24773223</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Congenital%20heart%20defects%2C%20multiple%20types%2C%207%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
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|
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<div class="supplemental col three_col last">
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C5394062%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C5394062%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C5394062%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (1)</a></li>
|
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C5394062%5bDISCUI%5d" target="_blank">See all (3)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=618780" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Congenital%20heart%20defects,%20multiple%20types,%207" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<a class="htb ralinkpopperctrl" ref="log$=activity&linkpos=1" href="/portal/utils/pageresolver.fcgi?recordid=67cc3369f4a390645e6f70d7">Congenital heart defects, multiple types, 7</a>
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