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<meta name="keywords" content="C3808986, disease or syndrome, flrt3, flrt3 hypogonadotropic hypogonadism, hh21, hypogonadotropic hypogonadism 21 with anosmia, hypogonadotropic hypogonadism 21 with or without anosmia, hypogonadotropic hypogonadism caused by mutation in flrt3, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt." /><meta name="robots" content="index,nofollow,noarchive" />
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<title>Hypogonadotropic hypogonadism 21 with or without anosmia (Concept Id: C3808986)
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<!--
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UID=815316
|
||
ConceptID=C3808986
|
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-->
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<!--imgCountBooks = 4--><div class="ncbi_carousel" data-ncbicarousel-config="imageWidth:'100px',numItemsVisible:2,toggler:false"><div class="nc_header"><span class="img_strip_title">Images (4)</span></div><div class="nc_content"><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image003.gif" src-large="/books/NBK1334/bin/kms-Image003.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F3/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image001.gif" src-large="/books/NBK1334/bin/kms-Image001.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F1/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image002.gif" src-large="/books/NBK1334/bin/kms-Image002.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F2/" title="GeneReviews" target="_blank">details</a></div><div class="nc_item"><a class="figpopup"><img alt="Image from GeneReviews" src="/books/NBK1334/bin/kms-Image004.gif" src-large="/books/NBK1334/bin/kms-Image004.jpg" /></a><br /><a href="/books/NBK1334/figure/kms.F4/" title="GeneReviews" target="_blank">details</a></div></div></div><h1 class="medgenTitle"><div class="MedGenTitleText">Hypogonadotropic hypogonadism 21 with or without anosmia<span class="h1sub">(HH21)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>815316</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C3808986</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>HH21; HYPOGONADOTROPIC HYPOGONADISM 21 WITH ANOSMIA</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="FLRT3 - ID: 23767 - NCBI Gene" href="/gene/23767" class="medgenPMinfo">FLRT3</a> (20p12.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0014107" target="_blank">MONDO:0014107</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/615271" target="_blank">615271</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1334" target="_blank">Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency</a></div><div>Isolated gonadotropin-releasing hormone (GnRH) deficiency (IGD) is characterized by inappropriately low serum concentrations of the gonadotropins LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in the presence of low circulating concentrations of sex steroids. IGD is associated with a normal sense of smell (normosmic IGD) in approximately 40% of affected individuals and an impaired sense of smell (Kallmann syndrome) in approximately 60%. IGD can first become apparent in infancy, adolescence, or adulthood. Infant boys with congenital IGD often have micropenis and cryptorchidism. Adolescents and adults with IGD have clinical evidence of hypogonadism and incomplete sexual maturation on physical examination. Adult males with IGD tend to have prepubertal testicular volume (i.e., <4 mL), absence of secondary sexual features (e.g., facial and axillary hair growth, deepening of the voice), decreased muscle mass, diminished libido, erectile dysfunction, and infertility. Adult females have little or no breast development and primary amenorrhea. Although skeletal maturation is delayed, the rate of linear growth is usually normal except for the absence of a distinct pubertal growth spurt. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1334#kms.Summary" target="NBK1334">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.GeneReview_Scope" target="NBK1334">GeneReview Scope</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Diagnosis" target="NBK1334">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Clinical_Characteristics" target="NBK1334">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Genetically_Related_Allelic_Disorder" target="NBK1334">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Differential_Diagnosis" target="NBK1334">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Management" target="NBK1334">Management</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Genetic_Counseling" target="NBK1334">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Resources" target="NBK1334">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Molecular_Genetics" target="NBK1334">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.Chapter_Notes" target="NBK1334">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1334#kms.References" target="NBK1334">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Ravikumar Balasubramanian | William F Crowley <a href="/books/NBK1334" target="NBK1334" title="NCBI Bookshelf: Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_description">Additional description</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Hypogonadotropic hypogonadism-21 (HH21) is characterized by partial or absent puberty in anosmic patients, in association with small testicular volumes in men and primary amenorrhea in women. Low bone mass has also been reported in some patients (Miraoui et al., 2013).
|
||
Congenital idiopathic hypogonadotropic hypogonadism (IHH) is a disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. Idiopathic hypogonadotropic hypogonadism can be caused by an isolated defect in gonadotropin-releasing hormone (GNRH; 152760) release, action, or both. Other associated nonreproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss, occur with variable frequency. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism has been called 'Kallmann syndrome (KS),' whereas in the presence of a normal sense of smell, it has been termed 'normosmic idiopathic hypogonadotropic hypogonadism (nIHH)' (summary by Raivio et al., 2007). Because families have been found to segregate both KS and nIHH, the disorder is here referred to as 'hypogonadotropic hypogonadism with or without anosmia (HH).'
|
||
For a discussion of genetic heterogeneity of hypogonadotropic hypogonadism with or without anosmia as well as a discussion of oligogenicity of this disorder, see 147950. <a target="_blank" href="http://www.omim.org/entry/615271">http://www.omim.org/entry/615271</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_235586"><div><strong>Hearing impairment</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>235586</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1384666</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A decreased magnitude of the sensory perception of sound.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/235586">Feature record</a> | <a href="/medgen?term=%22Hearing%20impairment%22%5BClinical%20Features%5D%20OR%20235586%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_473584"><div><strong>Hyposmia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>473584</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C2364082</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A decreased sensitivity to odorants (that is, a decreased ability to perceive odors).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/473584">Feature record</a> | <a href="/medgen?term=%22Hyposmia%22%5BClinical%20Features%5D%20OR%20473584%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_18222"><div><strong>Osteopenia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>18222</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0029453</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/18222">Feature record</a> | <a href="/medgen?term=%22Osteopenia%22%5BClinical%20Features%5D%20OR%2018222%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_14535"><div><strong>Osteoporosis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>14535</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0029456</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/14535">Feature record</a> | <a href="/medgen?term=%22Osteoporosis%22%5BClinical%20Features%5D%20OR%2014535%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_1370297"><div><strong>Cleft lip</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1370297</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4321245</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Anatomical Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A gap in the lip or lips.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1370297">Feature record</a> | <a href="/medgen?term=%22Cleft%20lip%22%5BClinical%20Features%5D%20OR%201370297%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_46203"><div><strong>Delayed puberty</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>46203</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0034012</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/46203">Feature record</a> | <a href="/medgen?term=%22Delayed%20puberty%22%5BClinical%20Features%5D%20OR%2046203%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of head or neck</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_1370297" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cleft lip</a></span></li></ul></li><li><span class="TLline">Abnormality of the endocrine system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_46203" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Delayed puberty</a></span></li></ul></li><li><span class="TLline">Abnormality of the musculoskeletal system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_18222" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteopenia</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_14535" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Osteoporosis</a></span></li></ul></li><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_473584" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hyposmia</a></span></li></ul></li><li><span class="TLline">Ear malformation</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_235586" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Hearing impairment</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32576618">Parkinson's disease: etiopathogenesis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jankovic J,
|
||
Tan EK</span><br />
|
||
<span class="medgenPMjournal">J Neurol Neurosurg Psychiatry</span>
|
||
2020 Aug;91(8):795-808.
|
||
Epub 2020 Jun 23
|
||
doi: 10.1136/jnnp-2019-322338.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32576618" target="_blank">32576618</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31296604">Investigation and management of subfertility.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thurston L,
|
||
Abbara A,
|
||
Dhillo WS</span><br />
|
||
<span class="medgenPMjournal">J Clin Pathol</span>
|
||
2019 Sep;72(9):579-587.
|
||
Epub 2019 Jul 11
|
||
doi: 10.1136/jclinpath-2018-205579.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31296604" target="_blank">31296604</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29108899">Kallmann syndrome: phenotype and genotype of hypogonadotropic hypogonadism.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stamou MI,
|
||
Georgopoulos NA</span><br />
|
||
<span class="medgenPMjournal">Metabolism</span>
|
||
2018 Sep;86:124-134.
|
||
Epub 2017 Nov 3
|
||
doi: 10.1016/j.metabol.2017.10.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29108899" target="_blank">29108899</a><a href="/pmc/articles/PMC5934335" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(hypogonadotropic%20hypogonadism%2021%20with%20or%20without%20anosmia)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (220)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
||
2024 Jan 3;190(1):S1-S11.
|
||
doi: 10.1093/ejendo/lvad166.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35633158">Neurological Sequelae of COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ahmad SJ,
|
||
Feigen CM,
|
||
Vazquez JP,
|
||
Kobets AJ,
|
||
Altschul DJ</span><br />
|
||
<span class="medgenPMjournal">J Integr Neurosci</span>
|
||
2022 Apr 6;21(3):77.
|
||
doi: 10.31083/j.jin2103077.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35633158" target="_blank">35633158</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33638460">Spiking dependence of SARS-CoV-2 pathogenicity on TMPRSS2.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Abbasi AZ,
|
||
Kiyani DA,
|
||
Hamid SM,
|
||
Saalim M,
|
||
Fahim A,
|
||
Jalal N</span><br />
|
||
<span class="medgenPMjournal">J Med Virol</span>
|
||
2021 Jul;93(7):4205-4218.
|
||
Epub 2021 Mar 18
|
||
doi: 10.1002/jmv.26911.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33638460" target="_blank">33638460</a><a href="/pmc/articles/PMC8014076" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32990925">Multiple Neuroinvasive Pathways in COVID-19.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bougakov D,
|
||
Podell K,
|
||
Goldberg E</span><br />
|
||
<span class="medgenPMjournal">Mol Neurobiol</span>
|
||
2021 Feb;58(2):564-575.
|
||
Epub 2020 Sep 29
|
||
doi: 10.1007/s12035-020-02152-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32990925" target="_blank">32990925</a><a href="/pmc/articles/PMC7523266" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33375030">Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ide V,
|
||
Vanderschueren D,
|
||
Antonio L</span><br />
|
||
<span class="medgenPMjournal">Int J Mol Sci</span>
|
||
2020 Dec 22;22(1)
|
||
doi: 10.3390/ijms22010021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33375030" target="_blank">33375030</a><a href="/pmc/articles/PMC7792781" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2021%20with%20or%20without%20anosmia%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2199)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37326322">Cardiovascular Safety of Testosterone-Replacement Therapy.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lincoff AM,
|
||
Bhasin S,
|
||
Flevaris P,
|
||
Mitchell LM,
|
||
Basaria S,
|
||
Boden WE,
|
||
Cunningham GR,
|
||
Granger CB,
|
||
Khera M,
|
||
Thompson IM Jr,
|
||
Wang Q,
|
||
Wolski K,
|
||
Davey D,
|
||
Kalahasti V,
|
||
Khan N,
|
||
Miller MG,
|
||
Snabes MC,
|
||
Chan A,
|
||
Dubcenco E,
|
||
Li X,
|
||
Yi T,
|
||
Huang B,
|
||
Pencina KM,
|
||
Travison TG,
|
||
Nissen SE;
|
||
TRAVERSE Study Investigators</span><br />
|
||
<span class="medgenPMjournal">N Engl J Med</span>
|
||
2023 Jul 13;389(2):107-117.
|
||
Epub 2023 Jun 16
|
||
doi: 10.1056/NEJMoa2215025.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37326322" target="_blank">37326322</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37059509">Assessment of heterogeneity among participants in the Parkinson's Progression Markers Initiative cohort using α-synuclein seed amplification: a cross-sectional study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Siderowf A,
|
||
Concha-Marambio L,
|
||
Lafontant DE,
|
||
Farris CM,
|
||
Ma Y,
|
||
Urenia PA,
|
||
Nguyen H,
|
||
Alcalay RN,
|
||
Chahine LM,
|
||
Foroud T,
|
||
Galasko D,
|
||
Kieburtz K,
|
||
Merchant K,
|
||
Mollenhauer B,
|
||
Poston KL,
|
||
Seibyl J,
|
||
Simuni T,
|
||
Tanner CM,
|
||
Weintraub D,
|
||
Videnovic A,
|
||
Choi SH,
|
||
Kurth R,
|
||
Caspell-Garcia C,
|
||
Coffey CS,
|
||
Frasier M,
|
||
Oliveira LMA,
|
||
Hutten SJ,
|
||
Sherer T,
|
||
Marek K,
|
||
Soto C;
|
||
Parkinson's Progression Markers Initiative</span><br />
|
||
<span class="medgenPMjournal">Lancet Neurol</span>
|
||
2023 May;22(5):407-417.
|
||
doi: 10.1016/S1474-4422(23)00109-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37059509" target="_blank">37059509</a><a href="/pmc/articles/PMC10627170" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36341691">Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dong Y,
|
||
Li Y,
|
||
Liu K,
|
||
Han X,
|
||
Liu R,
|
||
Ren Y,
|
||
Cong L,
|
||
Zhang Q,
|
||
Hou T,
|
||
Song L,
|
||
Tang S,
|
||
Shi L,
|
||
Luo Y,
|
||
Kalpouzos G,
|
||
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<div class="nl"><a target="_blank" href="/pubmed/35874953">Revealing the mystery of persistent smell loss in Long COVID patients.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Park JW,
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<div class="nl"><a target="_blank" href="/pubmed/26401583">Visual Vignette.</a></div>
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<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37467734">The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Patel B,
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Koysombat K,
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<div class="nl"><a target="_blank" href="/pubmed/38150256">Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism: A Randomized Clinical Trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bhasin S,
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Travison TG,
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<div class="nl"><a target="_blank" href="/pubmed/37326322">Cardiovascular Safety of Testosterone-Replacement Therapy.</a></div>
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Bhasin S,
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Flevaris P,
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Mitchell LM,
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Basaria S,
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Boden WE,
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Cunningham GR,
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<span class="bold">PMID: </span><a href="/pubmed/37326322" target="_blank">37326322</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33375030">Treatment of Men with Central Hypogonadism: Alternatives for Testosterone Replacement Therapy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Ide V,
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Vanderschueren D,
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<span class="bold">PMID: </span><a href="/pubmed/33375030" target="_blank">33375030</a><a href="/pmc/articles/PMC7792781" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2021%20with%20or%20without%20anosmia%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1050)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35874953">Revealing the mystery of persistent smell loss in Long COVID patients.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Park JW,
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Wang X,
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Xu RH</span><br />
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Epub 2022 Jul 15
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<span class="bold">PMID: </span><a href="/pubmed/35874953" target="_blank">35874953</a><a href="/pmc/articles/PMC9305264" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34853850">COVID-19 Legacy.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33378056">Nervous system complications of COVID-19 with a focus on stroke.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zhou YL,
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Lu J,
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<span class="bold">PMID: </span><a href="/pubmed/33378056" target="_blank">33378056</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Syeda S,
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Baptiste C,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2021%20with%20or%20without%20anosmia%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1030)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38150256">Prostate Safety Events During Testosterone Replacement Therapy in Men With Hypogonadism: A Randomized Clinical Trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bhasin S,
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Travison TG,
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Pencina KM,
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O'Leary M,
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Cunningham GR,
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Lincoff AM,
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Nissen SE,
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Lucia MS,
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Preston MA,
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Khera M,
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Khan N,
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Snabes MC,
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Li X,
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Tangen CM,
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Buhr KA,
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Thompson IM Jr</span><br />
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2023 Dec 1;6(12):e2348692.
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doi: 10.1001/jamanetworkopen.2023.48692.
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<span class="bold">PMID: </span><a href="/pubmed/38150256" target="_blank">38150256</a><a href="/pmc/articles/PMC10753401" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/37326322">Cardiovascular Safety of Testosterone-Replacement Therapy.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lincoff AM,
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Bhasin S,
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Flevaris P,
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Mitchell LM,
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Basaria S,
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Boden WE,
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Cunningham GR,
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Granger CB,
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Khera M,
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Thompson IM Jr,
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Wang Q,
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Wolski K,
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Davey D,
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Kalahasti V,
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Khan N,
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Miller MG,
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Snabes MC,
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Chan A,
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Dubcenco E,
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Li X,
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Yi T,
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Huang B,
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Pencina KM,
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Travison TG,
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Nissen SE;
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TRAVERSE Study Investigators</span><br />
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<span class="medgenPMjournal">N Engl J Med</span>
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2023 Jul 13;389(2):107-117.
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Epub 2023 Jun 16
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doi: 10.1056/NEJMoa2215025.
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<span class="bold">PMID: </span><a href="/pubmed/37326322" target="_blank">37326322</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36507615">Use of platelet-rich plasma for COVID-19-related olfactory loss: a randomized controlled trial.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Yan CH,
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Jang SS,
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Lin HC,
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Ma Y,
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<div class="nl"><a target="_blank" href="/pubmed/33864448">Clinical Profile of Adolescents With Delayed Puberty.</a></div>
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Prasad HK,
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<span class="bold">PMID: </span><a href="/pubmed/33864448" target="_blank">33864448</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/21897258">Metabolic syndrome and sexual dysfunction.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chughtai B,
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Lee RK,
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<span class="bold">PMID: </span><a href="/pubmed/21897258" target="_blank">21897258</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2021%20with%20or%20without%20anosmia%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1677)</a></div></div>
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</div>
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<div class="portlet mgSection" id="ID_104">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln">
|
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<div class="nl"><a target="_blank" href="/pubmed/38128110">Gonadotropins for pubertal induction in males with hypogonadotropic hypogonadism: systematic review and meta-analysis.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Alexander EC,
|
||
Faruqi D,
|
||
Farquhar R,
|
||
Unadkat A,
|
||
Ng Yin K,
|
||
Hoskyns R,
|
||
Varughese R,
|
||
Howard SR</span><br />
|
||
<span class="medgenPMjournal">Eur J Endocrinol</span>
|
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2024 Jan 3;190(1):S1-S11.
|
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doi: 10.1093/ejendo/lvad166.
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<span class="bold">PMID: </span><a href="/pubmed/38128110" target="_blank">38128110</a><a href="/pmc/articles/PMC10773669" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36725781">Does Olfactory Training Improve Brain Function and Cognition? A Systematic Review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Vance DE,
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Del Bene VA,
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Kamath V,
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Frank JS,
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Billings R,
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Cho DY,
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Byun JY,
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Jacob A,
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Anderson JN,
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Visscher K,
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Triebel K,
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Martin KM,
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Puga F,
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Fazeli PL</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/36725781" target="_blank">36725781</a><a href="/pmc/articles/PMC9891899" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35739136">Long-COVID in children and adolescents: a systematic review and meta-analyses.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lopez-Leon S,
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Wegman-Ostrosky T,
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Ayuzo Del Valle NC,
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Perelman C,
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Sepulveda R,
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Rebolledo PA,
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Cuapio A,
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<span class="bold">PMID: </span><a href="/pubmed/35739136" target="_blank">35739136</a><a href="/pmc/articles/PMC9226045" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34463956">Post-acute COVID-19 syndrome (PCS) and health-related quality of life (HRQoL)-A systematic review and meta-analysis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Malik P,
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Patel K,
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Pinto C,
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Jaiswal R,
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Tirupathi R,
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Pillai S,
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Patel U</span><br />
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<span class="medgenPMjournal">J Med Virol</span>
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2022 Jan;94(1):253-262.
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Epub 2021 Sep 7
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<span class="bold">PMID: </span><a href="/pubmed/34463956" target="_blank">34463956</a><a href="/pmc/articles/PMC8662132" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/32870978">COVID-19 in Health-Care Workers: A Living Systematic Review and Meta-Analysis of Prevalence, Risk Factors, Clinical Characteristics, and Outcomes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gómez-Ochoa SA,
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Franco OH,
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Rojas LZ,
|
||
Raguindin PF,
|
||
Roa-Díaz ZM,
|
||
Wyssmann BM,
|
||
Guevara SLR,
|
||
Echeverría LE,
|
||
Glisic M,
|
||
Muka T</span><br />
|
||
<span class="medgenPMjournal">Am J Epidemiol</span>
|
||
2021 Jan 4;190(1):161-175.
|
||
doi: 10.1093/aje/kwaa191.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32870978" target="_blank">32870978</a><a href="/pmc/articles/PMC7499478" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Hypogonadotropic%20hypogonadism%2021%20with%20or%20without%20anosmia%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (133)</a></div></div>
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C3808986%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (9)</a></li>
|
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<li><a href="/gtr/tests?term=C3808986%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C3808986%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (11)</a></li>
|
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<li><a href="/gtr/tests?term=C3808986%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (6)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C3808986%5bDISCUI%5d" target="_blank">See all (12)</a></total></li>
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