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<meta name="keywords" content="C3553302, disease or syndrome, keratoconus 5, ktcn5, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Keratoconus is a noninflammatory progressive corneal thinning disorder resulting in mixed myopia and irregular astigmatism. Characteristic features include stromal thinning, Vogt striae, Fleisher ring, and scissoring of the retinoscopic reflex with a fully dilated pupil. Symptoms usually develop in the second decade and are likely to progress in the third decade, whereas progression slows after age 30 years. The progression of keratoconus may result in severe visual impairment and some affected individuals require cornea transplantation. The prevalence of keratoconus is about 1 in 2,000 in Caucasian populations, and is a leading cause for cornea transplantation in developed countries (summary by Tang et al., 2005). For a discussion of genetic heterogeneity of keratoconus, see KTCN1 (148300)." /><meta name="robots" content="index,nofollow,noarchive" />
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||
<!--
|
||
UID=766216
|
||
ConceptID=C3553302
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Keratoconus 5<span class="h1sub">(KTCN5)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>766216</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C3553302</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>KTCN5</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0013830" target="_blank">MONDO:0013830</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/614622" target="_blank">614622</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Keratoconus is a noninflammatory progressive corneal thinning disorder resulting in mixed myopia and irregular astigmatism. Characteristic features include stromal thinning, Vogt striae, Fleisher ring, and scissoring of the retinoscopic reflex with a fully dilated pupil. Symptoms usually develop in the second decade and are likely to progress in the third decade, whereas progression slows after age 30 years. The progression of keratoconus may result in severe visual impairment and some affected individuals require cornea transplantation. The prevalence of keratoconus is about 1 in 2,000 in Caucasian populations, and is a leading cause for cornea transplantation in developed countries (summary by Tang et al., 2005). For a discussion of genetic heterogeneity of keratoconus, see KTCN1 (148300). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_44015"><div><strong>Keratoconus</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>44015</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0022578</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A cone-shaped deformity of the cornea characterized by the presence of corneal distortion secondary to thinning of the apex.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/44015">Feature record</a> | <a href="/medgen?term=%22Keratoconus%22%5BClinical%20Features%5D%20OR%2044015%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the eye</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_44015" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Keratoconus</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36774646">Comprehensive management of post-LASIK ectasia: From prevention to treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhao L,
|
||
Yin Y,
|
||
Hu T,
|
||
Du K,
|
||
Lu Y,
|
||
Fu Q,
|
||
Zhang Y,
|
||
Wu X,
|
||
Li Y,
|
||
Wen D</span><br />
|
||
<span class="medgenPMjournal">Acta Ophthalmol</span>
|
||
2023 Aug;101(5):485-503.
|
||
Epub 2023 Feb 12
|
||
doi: 10.1111/aos.15636.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36774646" target="_blank">36774646</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32641797">Current perspectives in the management of keratoconus with contact lenses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lim L,
|
||
Lim EWL</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2020 Dec;34(12):2175-2196.
|
||
Epub 2020 Jul 8
|
||
doi: 10.1038/s41433-020-1065-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32641797" target="_blank">32641797</a><a href="/pmc/articles/PMC7784906" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/13329317">Contact lenses in treatment of keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">RIDLEY F</span><br />
|
||
<span class="medgenPMjournal">Br J Ophthalmol</span>
|
||
1956 May;40(5):295-304.
|
||
doi: 10.1136/bjo.40.5.295.
|
||
<span class="bold">PMID: </span><a href="/pubmed/13329317" target="_blank">13329317</a><a href="/pmc/articles/PMC509484" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(keratoconus%205)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (99)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36543313">Large-Diameter Modified Big-Bubble Deep Anterior Lamellar Keratoplasty in Post-Radial Keratotomy Eyes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pellegrini M,
|
||
Yu AC,
|
||
Busin M</span><br />
|
||
<span class="medgenPMjournal">Am J Ophthalmol</span>
|
||
2023 Jul;251:1-4.
|
||
Epub 2022 Dec 18
|
||
doi: 10.1016/j.ajo.2022.12.012.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36543313" target="_blank">36543313</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36757242">Keratoconus and Fitness to Fly.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Delbarre M,
|
||
Crepy P,
|
||
Froussart-Maille F</span><br />
|
||
<span class="medgenPMjournal">Aerosp Med Hum Perform</span>
|
||
2022 Dec 1;93(12):840-845.
|
||
doi: 10.3357/AMHP.6050.2022.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36757242" target="_blank">36757242</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34991971">Keratoconus: An updated review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Santodomingo-Rubido J,
|
||
Carracedo G,
|
||
Suzaki A,
|
||
Villa-Collar C,
|
||
Vincent SJ,
|
||
Wolffsohn JS</span><br />
|
||
<span class="medgenPMjournal">Cont Lens Anterior Eye</span>
|
||
2022 Jun;45(3):101559.
|
||
Epub 2022 Jan 4
|
||
doi: 10.1016/j.clae.2021.101559.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34991971" target="_blank">34991971</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33502925">Correlation between Keratoconus and Pollution.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jurkiewicz T,
|
||
Marty AS</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Epidemiol</span>
|
||
2021 Dec;28(6):495-501.
|
||
Epub 2021 Jan 27
|
||
doi: 10.1080/09286586.2021.1879173.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33502925" target="_blank">33502925</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32448765">Diagnostic patterns in keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kreps EO,
|
||
Claerhout I,
|
||
Koppen C</span><br />
|
||
<span class="medgenPMjournal">Cont Lens Anterior Eye</span>
|
||
2021 Jun;44(3):101333.
|
||
Epub 2020 May 21
|
||
doi: 10.1016/j.clae.2020.05.002.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32448765" target="_blank">32448765</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconus%205%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1915)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36812937">Histopathological Changes in Corneal Ectasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bulirsch LM,
|
||
Löffler KU,
|
||
Holz FG,
|
||
Herwig-Carl MC</span><br />
|
||
<span class="medgenPMjournal">Klin Monbl Augenheilkd</span>
|
||
2023 Jun;240(6):803-809.
|
||
Epub 2023 Feb 22
|
||
doi: 10.1055/a-2040-8283.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36812937" target="_blank">36812937</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34991971">Keratoconus: An updated review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Santodomingo-Rubido J,
|
||
Carracedo G,
|
||
Suzaki A,
|
||
Villa-Collar C,
|
||
Vincent SJ,
|
||
Wolffsohn JS</span><br />
|
||
<span class="medgenPMjournal">Cont Lens Anterior Eye</span>
|
||
2022 Jun;45(3):101559.
|
||
Epub 2022 Jan 4
|
||
doi: 10.1016/j.clae.2021.101559.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34991971" target="_blank">34991971</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34269743">Vernal keratoconjunctivitis and keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wajnsztajn D,
|
||
Solomon A</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Allergy Clin Immunol</span>
|
||
2021 Oct 1;21(5):507-514.
|
||
doi: 10.1097/ACI.0000000000000765.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34269743" target="_blank">34269743</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33754677">Keratoconus more common than widely assumed.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kristianslund O,
|
||
Tovås LC,
|
||
Thorsrud A,
|
||
Drolsum L</span><br />
|
||
<span class="medgenPMjournal">Tidsskr Nor Laegeforen</span>
|
||
2021 Mar 23;141(5)
|
||
Epub 2021 Mar 22
|
||
doi: 10.4045/tidsskr.20.1059.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33754677" target="_blank">33754677</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23252029">Corneal cross-linking and keratoconus: the change in treatment paradigm of keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Koppen C</span><br />
|
||
<span class="medgenPMjournal">Bull Soc Belge Ophtalmol</span>
|
||
2012;(321):5, 9-23, 25-7 passim.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23252029" target="_blank">23252029</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconus%205%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (1150)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/35502012">Complications of corneal collagen cross-linking.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Agarwal R,
|
||
Jain P,
|
||
Arora R</span><br />
|
||
<span class="medgenPMjournal">Indian J Ophthalmol</span>
|
||
2022 May;70(5):1466-1474.
|
||
doi: 10.4103/ijo.IJO_1595_21.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35502012" target="_blank">35502012</a><a href="/pmc/articles/PMC9333012" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29738584">Corneal Allogenic Intrastromal Ring Segments (CAIRS) Combined With Corneal Cross-linking for Keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacob S,
|
||
Patel SR,
|
||
Agarwal A,
|
||
Ramalingam A,
|
||
Saijimol AI,
|
||
Raj JM</span><br />
|
||
<span class="medgenPMjournal">J Refract Surg</span>
|
||
2018 May 1;34(5):296-303.
|
||
doi: 10.3928/1081597X-20180223-01.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29738584" target="_blank">29738584</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25760913">Microbiologic Examination of Bandage Contact Lenses Used after Corneal Collagen Cross-linking Treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yuksel E,
|
||
Yalcin NG,
|
||
Kilic G,
|
||
Cubuk MO,
|
||
Ozmen MC,
|
||
Altay A,
|
||
Çağlar K,
|
||
Bilgihan K</span><br />
|
||
<span class="medgenPMjournal">Ocul Immunol Inflamm</span>
|
||
2016;24(2):217-22.
|
||
Epub 2015 Mar 11
|
||
doi: 10.3109/09273948.2014.1001518.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25760913" target="_blank">25760913</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23252029">Corneal cross-linking and keratoconus: the change in treatment paradigm of keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Koppen C</span><br />
|
||
<span class="medgenPMjournal">Bull Soc Belge Ophtalmol</span>
|
||
2012;(321):5, 9-23, 25-7 passim.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23252029" target="_blank">23252029</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12719068">Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wollensak G,
|
||
Spoerl E,
|
||
Seiler T</span><br />
|
||
<span class="medgenPMjournal">Am J Ophthalmol</span>
|
||
2003 May;135(5):620-7.
|
||
doi: 10.1016/s0002-9394(02)02220-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12719068" target="_blank">12719068</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconus%205%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (977)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32703026">Evolution of corneal flattening after repeated corneal cross-linking during a 6-year follow-up.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grentzelos MA,
|
||
Voulgari N,
|
||
Giacuzzo C,
|
||
Droutsas K,
|
||
Kymionis GD</span><br />
|
||
<span class="medgenPMjournal">Eur J Ophthalmol</span>
|
||
2022 Jan;32(1):NP12-NP14.
|
||
Epub 2020 Jul 24
|
||
doi: 10.1177/1120672120945662.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32703026" target="_blank">32703026</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33340508">Individualized Corneal Cross-linking With Riboflavin and UV-A in Ultrathin Corneas: The Sub400 Protocol.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hafezi F,
|
||
Kling S,
|
||
Gilardoni F,
|
||
Hafezi N,
|
||
Hillen M,
|
||
Abrishamchi R,
|
||
Gomes JAP,
|
||
Mazzotta C,
|
||
Randleman JB,
|
||
Torres-Netto EA</span><br />
|
||
<span class="medgenPMjournal">Am J Ophthalmol</span>
|
||
2021 Apr;224:133-142.
|
||
Epub 2021 Jan 30
|
||
doi: 10.1016/j.ajo.2020.12.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33340508" target="_blank">33340508</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28852910">Pediatric keratoconus: a review of the literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Mukhtar S,
|
||
Ambati BK</span><br />
|
||
<span class="medgenPMjournal">Int Ophthalmol</span>
|
||
2018 Oct;38(5):2257-2266.
|
||
Epub 2017 Aug 29
|
||
doi: 10.1007/s10792-017-0699-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28852910" target="_blank">28852910</a><a href="/pmc/articles/PMC5856649" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23458981">Template-based correction of high-order aberration in keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marsack JD,
|
||
Rozema JJ,
|
||
Koppen C,
|
||
Tassignon MJ,
|
||
Applegate RA</span><br />
|
||
<span class="medgenPMjournal">Optom Vis Sci</span>
|
||
2013 Apr;90(4):324-34.
|
||
doi: 10.1097/OPX.0b013e318288c2b1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23458981" target="_blank">23458981</a><a href="/pmc/articles/PMC3661222" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18615241">Superior keratoconus with hydrops.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tananuvat N,
|
||
Leeungurasatien P,
|
||
Wiriyaluppa C</span><br />
|
||
<span class="medgenPMjournal">Int Ophthalmol</span>
|
||
2009 Oct;29(5):419-21.
|
||
Epub 2008 Jul 10
|
||
doi: 10.1007/s10792-008-9244-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18615241" target="_blank">18615241</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconus%205%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (870)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37490610">Ocular surface inflammation and ectatic corneal disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Erdinest N,
|
||
Wajnsztajn D,
|
||
London N,
|
||
Solomon A</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Allergy Clin Immunol</span>
|
||
2023 Oct 1;23(5):430-437.
|
||
Epub 2023 Jul 24
|
||
doi: 10.1097/ACI.0000000000000935.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37490610" target="_blank">37490610</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35050519">The association between keratoconus and allergic eye diseases: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Seth I,
|
||
Bulloch G,
|
||
Vine M,
|
||
Outmezguine J,
|
||
Seth N,
|
||
Every J,
|
||
Daniell M</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Ophthalmol</span>
|
||
2022 Apr;50(3):280-293.
|
||
Epub 2022 Feb 2
|
||
doi: 10.1111/ceo.14045.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35050519" target="_blank">35050519</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34991971">Keratoconus: An updated review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Santodomingo-Rubido J,
|
||
Carracedo G,
|
||
Suzaki A,
|
||
Villa-Collar C,
|
||
Vincent SJ,
|
||
Wolffsohn JS</span><br />
|
||
<span class="medgenPMjournal">Cont Lens Anterior Eye</span>
|
||
2022 Jun;45(3):101559.
|
||
Epub 2022 Jan 4
|
||
doi: 10.1016/j.clae.2021.101559.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34991971" target="_blank">34991971</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33340508">Individualized Corneal Cross-linking With Riboflavin and UV-A in Ultrathin Corneas: The Sub400 Protocol.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hafezi F,
|
||
Kling S,
|
||
Gilardoni F,
|
||
Hafezi N,
|
||
Hillen M,
|
||
Abrishamchi R,
|
||
Gomes JAP,
|
||
Mazzotta C,
|
||
Randleman JB,
|
||
Torres-Netto EA</span><br />
|
||
<span class="medgenPMjournal">Am J Ophthalmol</span>
|
||
2021 Apr;224:133-142.
|
||
Epub 2021 Jan 30
|
||
doi: 10.1016/j.ajo.2020.12.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33340508" target="_blank">33340508</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29738584">Corneal Allogenic Intrastromal Ring Segments (CAIRS) Combined With Corneal Cross-linking for Keratoconus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacob S,
|
||
Patel SR,
|
||
Agarwal A,
|
||
Ramalingam A,
|
||
Saijimol AI,
|
||
Raj JM</span><br />
|
||
<span class="medgenPMjournal">J Refract Surg</span>
|
||
2018 May 1;34(5):296-303.
|
||
doi: 10.3928/1081597X-20180223-01.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29738584" target="_blank">29738584</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconus%205%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (818)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/36882200">The association between keratoconus and allergic eye diseases: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Seth I,
|
||
Bulloch G,
|
||
Vine M,
|
||
Outmezguine J,
|
||
Seth N,
|
||
Every J,
|
||
Daniell M</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Ophthalmol</span>
|
||
2023 May-Jun;51(4):O1-O16.
|
||
Epub 2023 Mar 7
|
||
doi: 10.1111/ceo.14215.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36882200" target="_blank">36882200</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35050519">The association between keratoconus and allergic eye diseases: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Seth I,
|
||
Bulloch G,
|
||
Vine M,
|
||
Outmezguine J,
|
||
Seth N,
|
||
Every J,
|
||
Daniell M</span><br />
|
||
<span class="medgenPMjournal">Clin Exp Ophthalmol</span>
|
||
2022 Apr;50(3):280-293.
|
||
Epub 2022 Feb 2
|
||
doi: 10.1111/ceo.14045.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35050519" target="_blank">35050519</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33860963">Keratoconus in Africa: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Akowuah PK,
|
||
Kobia-Acquah E,
|
||
Donkor R,
|
||
Adjei-Anang J,
|
||
Ankamah-Lomotey S</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Physiol Opt</span>
|
||
2021 Jul;41(4):736-747.
|
||
Epub 2021 Apr 16
|
||
doi: 10.1111/opo.12825.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33860963" target="_blank">33860963</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28676647">Genetic associations for keratoconus: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rong SS,
|
||
Ma STU,
|
||
Yu XT,
|
||
Ma L,
|
||
Chu WK,
|
||
Chan TCY,
|
||
Wang YM,
|
||
Young AL,
|
||
Pang CP,
|
||
Jhanji V,
|
||
Chen LJ</span><br />
|
||
<span class="medgenPMjournal">Sci Rep</span>
|
||
2017 Jul 4;7(1):4620.
|
||
doi: 10.1038/s41598-017-04393-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28676647" target="_blank">28676647</a><a href="/pmc/articles/PMC5496893" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27678078">Cross-linking in children with keratoconus: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">McAnena L,
|
||
Doyle F,
|
||
O'Keefe M</span><br />
|
||
<span class="medgenPMjournal">Acta Ophthalmol</span>
|
||
2017 May;95(3):229-239.
|
||
Epub 2016 Sep 28
|
||
doi: 10.1111/aos.13224.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27678078" target="_blank">27678078</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Keratoconus%205%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (33)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=614622" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Keratoconus%205" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(keratoconus%205)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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