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<meta name="keywords" content="C2751642, finding, glioma susceptibility 2, glioma susceptibility type 2, glm2, malignant glioma caused by mutation in pten, pten, pten malignant glioma, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Any malignant glioma in which the cause of the disease is a mutation in the PTEN gene." /><meta name="robots" content="index,nofollow,noarchive" />
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|
||
<!--
|
||
UID=414431
|
||
ConceptID=C2751642
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Glioma susceptibility 2<span class="h1sub">(GLM2)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>414431</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2751642</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>GLM2</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="PTEN - ID: 5728 - NCBI Gene" href="/gene/5728" class="medgenPMinfo">PTEN</a> (10q23.31)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0013092" target="_blank">MONDO:0013092</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/613028" target="_blank">613028</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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||
<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Any malignant glioma in which the cause of the disease is a mutation in the PTEN gene. [from <a title="Monarch Initiative" href="https://monarchinitiative.org/" class="defSource" target="_blank">MONDO</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_7532"><div><strong>Meningioma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>7532</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0025286</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of a meningioma, i.e., a benign tumor originating from the dura mater or arachnoid mater.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/7532">Feature record</a> | <a href="/medgen?term=%22Meningioma%22%5BClinical%20Features%5D%20OR%207532%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_45190"><div><strong>Oligodendroglioma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45190</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0028945</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Oligodendroglioma is a type of diffusely infiltrating glioma and constitutes approximately 5% of primary intracranial tumors. They often involve the cortical gray matter and are most commonly seen in the frontal lobes. OGs are generally low grade WHO grade II neoplasms that are slow-growing tumors and have a favorable treatment response when compared to other gliomas. Grade III anaplastic OG is a more malignant form of the tumor which portends a less favorable prognosis and may occur de novo or as degeneration from the lower grade OG.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/45190">Feature record</a> | <a href="/medgen?term=%22Oligodendroglioma%22%5BClinical%20Features%5D%20OR%2045190%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_7532" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Meningioma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_45190" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Oligodendroglioma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32620889">Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zhang YD,
|
||
Hurson AN,
|
||
Zhang H,
|
||
Choudhury PP,
|
||
Easton DF,
|
||
Milne RL,
|
||
Simard J,
|
||
Hall P,
|
||
Michailidou K,
|
||
Dennis J,
|
||
Schmidt MK,
|
||
Chang-Claude J,
|
||
Gharahkhani P,
|
||
Whiteman D,
|
||
Campbell PT,
|
||
Hoffmeister M,
|
||
Jenkins M,
|
||
Peters U,
|
||
Hsu L,
|
||
Gruber SB,
|
||
Casey G,
|
||
Schmit SL,
|
||
O'Mara TA,
|
||
Spurdle AB,
|
||
Thompson DJ,
|
||
Tomlinson I,
|
||
De Vivo I,
|
||
Landi MT,
|
||
Law MH,
|
||
Iles MM,
|
||
Demenais F,
|
||
Kumar R,
|
||
MacGregor S,
|
||
Bishop DT,
|
||
Ward SV,
|
||
Bondy ML,
|
||
Houlston R,
|
||
Wiencke JK,
|
||
Melin B,
|
||
Barnholtz-Sloan J,
|
||
Kinnersley B,
|
||
Wrensch MR,
|
||
Amos CI,
|
||
Hung RJ,
|
||
Brennan P,
|
||
McKay J,
|
||
Caporaso NE,
|
||
Berndt SI,
|
||
Birmann BM,
|
||
Camp NJ,
|
||
Kraft P,
|
||
Rothman N,
|
||
Slager SL,
|
||
Berchuck A,
|
||
Pharoah PDP,
|
||
Sellers TA,
|
||
Gayther SA,
|
||
Pearce CL,
|
||
Goode EL,
|
||
Schildkraut JM,
|
||
Moysich KB,
|
||
Amundadottir LT,
|
||
Jacobs EJ,
|
||
Klein AP,
|
||
Petersen GM,
|
||
Risch HA,
|
||
Stolzenberg-Solomon RZ,
|
||
Wolpin BM,
|
||
Li D,
|
||
Eeles RA,
|
||
Haiman CA,
|
||
Kote-Jarai Z,
|
||
Schumacher FR,
|
||
Al Olama AA,
|
||
Purdue MP,
|
||
Scelo G,
|
||
Dalgaard MD,
|
||
Greene MH,
|
||
Grotmol T,
|
||
Kanetsky PA,
|
||
McGlynn KA,
|
||
Nathanson KL,
|
||
Turnbull C,
|
||
Wiklund F;
|
||
Breast Cancer Association Consortium (BCAC);
|
||
Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON);
|
||
Colon Cancer Family Registry (CCFR);
|
||
Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT);
|
||
Endometrial Cancer Association Consortium (ECAC);
|
||
Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO);
|
||
Melanoma Genetics Consortium (GenoMEL);
|
||
Glioma International Case-Control Study (GICC);
|
||
International Lung Cancer Consortium (ILCCO);
|
||
Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium;
|
||
International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph);
|
||
Ovarian Cancer Association Consortium (OCAC);
|
||
Oral Cancer GWAS;
|
||
Pancreatic Cancer Case-Control Consortium (PanC4);
|
||
Pancreatic Cancer Cohort Consortium (PanScan);
|
||
Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL);
|
||
Renal Cancer GWAS;
|
||
Testicular Cancer Consortium (TECAC),
|
||
Chanock SJ,
|
||
Chatterjee N,
|
||
Garcia-Closas M</span><br />
|
||
<span class="medgenPMjournal">Nat Commun</span>
|
||
2020 Jul 3;11(1):3353.
|
||
doi: 10.1038/s41467-020-16483-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32620889" target="_blank">32620889</a><a href="/pmc/articles/PMC7335068" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25727224">Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen R,
|
||
Ravindra VM,
|
||
Cohen AL,
|
||
Jensen RL,
|
||
Salzman KL,
|
||
Prescot AP,
|
||
Colman H</span><br />
|
||
<span class="medgenPMjournal">Neurosurg Focus</span>
|
||
2015 Mar;38(3):E2.
|
||
doi: 10.3171/2015.1.FOCUS14745.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25727224" target="_blank">25727224</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24114756">Using the molecular classification of glioblastoma to inform personalized treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Olar A,
|
||
Aldape KD</span><br />
|
||
<span class="medgenPMjournal">J Pathol</span>
|
||
2014 Jan;232(2):165-77.
|
||
doi: 10.1002/path.4282.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24114756" target="_blank">24114756</a><a href="/pmc/articles/PMC4138801" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(glioma%20susceptibility%202)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (44)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36929942">Genome-wide analyses characterize shared heritability among cancers and identify novel cancer susceptibility regions.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lindström S,
|
||
Wang L,
|
||
Feng H,
|
||
Majumdar A,
|
||
Huo S,
|
||
Macdonald J,
|
||
Harrison T,
|
||
Turman C,
|
||
Chen H,
|
||
Mancuso N,
|
||
Bammler T;
|
||
Breast Cancer Association Consortium (BCAC),
|
||
Gallinger S,
|
||
Gruber SB,
|
||
Gunter MJ,
|
||
Le Marchand L,
|
||
Moreno V,
|
||
Offit K;
|
||
Colorectal Transdisciplinary Study (CORECT), Colon Cancer Family Registry Study (CCFR), Genetics And Epidemiology Of Colorectal Cancer Consortium (GECCO),
|
||
De Vivo I,
|
||
O'Mara TA,
|
||
Spurdle AB,
|
||
Tomlinson I;
|
||
Endometrial Cancer Association Consortium (ECAC),
|
||
Fitzgerald R,
|
||
Gharahkhani P,
|
||
Gockel I,
|
||
Jankowski J,
|
||
Macgregor S,
|
||
Schumacher J,
|
||
Barnholtz-Sloan J,
|
||
Bondy ML,
|
||
Houlston RS,
|
||
Jenkins RB,
|
||
Melin B,
|
||
Wrensch M,
|
||
Brennan P,
|
||
Christiani DC,
|
||
Johansson M,
|
||
Mckay J,
|
||
Aldrich MC,
|
||
Amos CI,
|
||
Landi MT,
|
||
Tardon A;
|
||
International Lung Cancer Consortium (ILCCO),
|
||
Bishop DT,
|
||
Demenais F,
|
||
Goldstein AM,
|
||
Iles MM,
|
||
Kanetsky PA,
|
||
Law MH;
|
||
Ovarian Cancer Association Consortium (OCAC),
|
||
Amundadottir LT,
|
||
Stolzenberg-Solomon R,
|
||
Wolpin BM;
|
||
Pancreatic Cancer Cohort Consortium (Panscan),
|
||
Klein A,
|
||
Petersen G,
|
||
Risch H;
|
||
Pancreatic Cancer Case-Control Consortium (Panc4), The PRACTICAL Consortium,
|
||
Chanock SJ,
|
||
Purdue MP,
|
||
Scelo G,
|
||
Pharoah P,
|
||
Kar S,
|
||
Hung RJ,
|
||
Pasaniuc B,
|
||
Kraft P</span><br />
|
||
<span class="medgenPMjournal">J Natl Cancer Inst</span>
|
||
2023 Jun 8;115(6):712-732.
|
||
doi: 10.1093/jnci/djad043.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36929942" target="_blank">36929942</a><a href="/pmc/articles/PMC10248849" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29953370">Radiation-Induced Gliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aherne NJ,
|
||
Murphy BM</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncog</span>
|
||
2018;23(1-2):113-118.
|
||
doi: 10.1615/CritRevOncog.2018025740.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29953370" target="_blank">29953370</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28346443">Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Melin BS,
|
||
Barnholtz-Sloan JS,
|
||
Wrensch MR,
|
||
Johansen C,
|
||
Il'yasova D,
|
||
Kinnersley B,
|
||
Ostrom QT,
|
||
Labreche K,
|
||
Chen Y,
|
||
Armstrong G,
|
||
Liu Y,
|
||
Eckel-Passow JE,
|
||
Decker PA,
|
||
Labussière M,
|
||
Idbaih A,
|
||
Hoang-Xuan K,
|
||
Di Stefano AL,
|
||
Mokhtari K,
|
||
Delattre JY,
|
||
Broderick P,
|
||
Galan P,
|
||
Gousias K,
|
||
Schramm J,
|
||
Schoemaker MJ,
|
||
Fleming SJ,
|
||
Herms S,
|
||
Heilmann S,
|
||
Nöthen MM,
|
||
Wichmann HE,
|
||
Schreiber S,
|
||
Swerdlow A,
|
||
Lathrop M,
|
||
Simon M,
|
||
Sanson M,
|
||
Andersson U,
|
||
Rajaraman P,
|
||
Chanock S,
|
||
Linet M,
|
||
Wang Z,
|
||
Yeager M;
|
||
GliomaScan Consortium,
|
||
Wiencke JK,
|
||
Hansen H,
|
||
McCoy L,
|
||
Rice T,
|
||
Kosel ML,
|
||
Sicotte H,
|
||
Amos CI,
|
||
Bernstein JL,
|
||
Davis F,
|
||
Lachance D,
|
||
Lau C,
|
||
Merrell RT,
|
||
Shildkraut J,
|
||
Ali-Osman F,
|
||
Sadetzki S,
|
||
Scheurer M,
|
||
Shete S,
|
||
Lai RK,
|
||
Claus EB,
|
||
Olson SH,
|
||
Jenkins RB,
|
||
Houlston RS,
|
||
Bondy ML</span><br />
|
||
<span class="medgenPMjournal">Nat Genet</span>
|
||
2017 May;49(5):789-794.
|
||
Epub 2017 Mar 27
|
||
doi: 10.1038/ng.3823.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28346443" target="_blank">28346443</a><a href="/pmc/articles/PMC5558246" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24193082">Glioblastoma and other malignant gliomas: a clinical review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Omuro A,
|
||
DeAngelis LM</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2013 Nov 6;310(17):1842-50.
|
||
doi: 10.1001/jama.2013.280319.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24193082" target="_blank">24193082</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10880719">Neurocysticercosis and oncogenesis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Del Brutto OH,
|
||
Dolezal M,
|
||
Castillo PR,
|
||
García HH</span><br />
|
||
<span class="medgenPMjournal">Arch Med Res</span>
|
||
2000 Mar-Apr;31(2):151-5.
|
||
doi: 10.1016/s0188-4409(00)00049-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10880719" target="_blank">10880719</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%202%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (634)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31161239">An update on the CNS manifestations of neurofibromatosis type 2.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Coy S,
|
||
Rashid R,
|
||
Stemmer-Rachamimov A,
|
||
Santagata S</span><br />
|
||
<span class="medgenPMjournal">Acta Neuropathol</span>
|
||
2020 Apr;139(4):643-665.
|
||
Epub 2019 Jun 4
|
||
doi: 10.1007/s00401-019-02029-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31161239" target="_blank">31161239</a><a href="/pmc/articles/PMC7038792" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30664951">Oligo-astrocytoma in LZTR1-related Noonan syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Jacquinet A,
|
||
Bonnard A,
|
||
Capri Y,
|
||
Martin D,
|
||
Sadzot B,
|
||
Bianchi E,
|
||
Servais L,
|
||
Sacré JP,
|
||
Cavé H,
|
||
Verloes A</span><br />
|
||
<span class="medgenPMjournal">Eur J Med Genet</span>
|
||
2020 Jan;63(1):103617.
|
||
Epub 2019 Jan 19
|
||
doi: 10.1016/j.ejmg.2019.01.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30664951" target="_blank">30664951</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31718568">System-based approaches as prognostic tools for glioblastoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salvucci M,
|
||
Zakaria Z,
|
||
Carberry S,
|
||
Tivnan A,
|
||
Seifert V,
|
||
Kögel D,
|
||
Murphy BM,
|
||
Prehn JHM</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2019 Nov 12;19(1):1092.
|
||
doi: 10.1186/s12885-019-6280-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31718568" target="_blank">31718568</a><a href="/pmc/articles/PMC6852738" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29953370">Radiation-Induced Gliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aherne NJ,
|
||
Murphy BM</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncog</span>
|
||
2018;23(1-2):113-118.
|
||
doi: 10.1615/CritRevOncog.2018025740.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29953370" target="_blank">29953370</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24193082">Glioblastoma and other malignant gliomas: a clinical review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Omuro A,
|
||
DeAngelis LM</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2013 Nov 6;310(17):1842-50.
|
||
doi: 10.1001/jama.2013.280319.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24193082" target="_blank">24193082</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%202%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (570)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39375303">Vorasidenib: First Approval.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lamb YN</span><br />
|
||
<span class="medgenPMjournal">Drugs</span>
|
||
2024 Oct;84(10):1325-1331.
|
||
Epub 2024 Oct 8
|
||
doi: 10.1007/s40265-024-02097-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39375303" target="_blank">39375303</a><a href="/pmc/articles/PMC11628568" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36125896">H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Haase S,
|
||
Banerjee K,
|
||
Mujeeb AA,
|
||
Hartlage CS,
|
||
Núñez FM,
|
||
Núñez FJ,
|
||
Alghamri MS,
|
||
Kadiyala P,
|
||
Carney S,
|
||
Barissi MN,
|
||
Taher AW,
|
||
Brumley EK,
|
||
Thompson S,
|
||
Dreyer JT,
|
||
Alindogan CT,
|
||
Garcia-Fabiani MB,
|
||
Comba A,
|
||
Venneti S,
|
||
Ravikumar V,
|
||
Koschmann C,
|
||
Carcaboso ÁM,
|
||
Vinci M,
|
||
Rao A,
|
||
Yu JS,
|
||
Lowenstein PR,
|
||
Castro MG</span><br />
|
||
<span class="medgenPMjournal">J Clin Invest</span>
|
||
2022 Nov 15;132(22)
|
||
doi: 10.1172/JCI154229.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36125896" target="_blank">36125896</a><a href="/pmc/articles/PMC9663161" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32037183">Tumor antigens in glioma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nejo T,
|
||
Yamamichi A,
|
||
Almeida ND,
|
||
Goretsky YE,
|
||
Okada H</span><br />
|
||
<span class="medgenPMjournal">Semin Immunol</span>
|
||
2020 Feb;47:101385.
|
||
Epub 2020 Feb 6
|
||
doi: 10.1016/j.smim.2020.101385.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32037183" target="_blank">32037183</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29953370">Radiation-Induced Gliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Aherne NJ,
|
||
Murphy BM</span><br />
|
||
<span class="medgenPMjournal">Crit Rev Oncog</span>
|
||
2018;23(1-2):113-118.
|
||
doi: 10.1615/CritRevOncog.2018025740.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29953370" target="_blank">29953370</a></div>
|
||
|
||
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Haycock PC,
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Timpson NJ,
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Evans DM,
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Willeit P,
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Gaunt TR,
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Kurian KM,
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Bowdler LM,
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Iles MM,
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Yang Q,
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Worrall BB,
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Markus HS,
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Hung RJ,
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Amos CI,
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Spurdle AB,
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Thompson DJ,
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Wolpin B,
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Stolzenberg-Solomon R,
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Trichopoulou A,
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Overvad K,
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Gunter MJ,
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Tumino R,
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Svenson U,
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Baas AF,
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Bown MJ,
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Samani NJ,
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van t'Hof FNG,
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Tromp G,
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Jones GT,
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Kuivaniemi H,
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Elmore JR,
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Johansson M,
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Mckay J,
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Scelo G,
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Carreras-Torres R,
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Gaborieau V,
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Brennan P,
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Bracci PM,
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Neale RE,
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Olson SH,
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Gallinger S,
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Li D,
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Petersen GM,
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Risch HA,
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Klein AP,
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Han J,
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Abnet CC,
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Freedman ND,
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Taylor PR,
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Maris JM,
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Aben KK,
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Kiemeney LA,
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Vermeulen SH,
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Wiencke JK,
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Walsh KM,
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Wrensch M,
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Rice T,
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Turnbull C,
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Litchfield K,
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Paternoster L,
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Standl M,
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Abecasis GR,
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SanGiovanni JP,
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Li Y,
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Mijatovic V,
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Sapkota Y,
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Low SK,
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Zondervan KT,
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Montgomery GW,
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Nyholt DR,
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van Heel DA,
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Hunt K,
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Arking DE,
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Ashar FN,
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Sotoodehnia N,
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Woo D,
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Rosand J,
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Brown WM,
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Silverman EK,
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Hui J,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%202%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (215)</a></div><h3 class="subhead">Prognosis</h3>
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Haycock PC,
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Nounu A,
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Zheng J,
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Okoli GN,
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Bowden J,
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Wade KH,
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Timpson NJ,
|
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Evans DM,
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Willeit P,
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Aviv A,
|
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Gaunt TR,
|
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Hemani G,
|
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Mangino M,
|
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Ellis HP,
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Kurian KM,
|
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Pooley KA,
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Eeles RA,
|
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Lee JE,
|
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Fang S,
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Chen WV,
|
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Law MH,
|
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Bowdler LM,
|
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Iles MM,
|
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Yang Q,
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Worrall BB,
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Markus HS,
|
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Hung RJ,
|
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Amos CI,
|
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Spurdle AB,
|
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Thompson DJ,
|
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O'Mara TA,
|
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Wolpin B,
|
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Amundadottir L,
|
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Stolzenberg-Solomon R,
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Trichopoulou A,
|
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Onland-Moret NC,
|
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Lund E,
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Duell EJ,
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Canzian F,
|
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Severi G,
|
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Overvad K,
|
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Gunter MJ,
|
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Tumino R,
|
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Svenson U,
|
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van Rij A,
|
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Baas AF,
|
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Bown MJ,
|
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Samani NJ,
|
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van t'Hof FNG,
|
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Tromp G,
|
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Jones GT,
|
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Kuivaniemi H,
|
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Elmore JR,
|
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Johansson M,
|
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Mckay J,
|
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Scelo G,
|
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Carreras-Torres R,
|
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Gaborieau V,
|
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Brennan P,
|
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Bracci PM,
|
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Neale RE,
|
||
Olson SH,
|
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Gallinger S,
|
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Li D,
|
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Petersen GM,
|
||
Risch HA,
|
||
Klein AP,
|
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Han J,
|
||
Abnet CC,
|
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Freedman ND,
|
||
Taylor PR,
|
||
Maris JM,
|
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Aben KK,
|
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Kiemeney LA,
|
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Vermeulen SH,
|
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Wiencke JK,
|
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Walsh KM,
|
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Wrensch M,
|
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Rice T,
|
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Turnbull C,
|
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Litchfield K,
|
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Paternoster L,
|
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Standl M,
|
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Abecasis GR,
|
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SanGiovanni JP,
|
||
Li Y,
|
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Mijatovic V,
|
||
Sapkota Y,
|
||
Low SK,
|
||
Zondervan KT,
|
||
Montgomery GW,
|
||
Nyholt DR,
|
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van Heel DA,
|
||
Hunt K,
|
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Arking DE,
|
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Ashar FN,
|
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Sotoodehnia N,
|
||
Woo D,
|
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Rosand J,
|
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Comeau ME,
|
||
Brown WM,
|
||
Silverman EK,
|
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Hokanson JE,
|
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Cho MH,
|
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Hui J,
|
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Ferreira MA,
|
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Thompson PJ,
|
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Morrison AC,
|
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Felix JF,
|
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Smith NL,
|
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Christiano AM,
|
||
Petukhova L,
|
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Betz RC,
|
||
Fan X,
|
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Zhang X,
|
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Zhu C,
|
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Langefeld CD,
|
||
Thompson SD,
|
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Wang F,
|
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Lin X,
|
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Schwartz DA,
|
||
Fingerlin T,
|
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Rotter JI,
|
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Cotch MF,
|
||
Jensen RA,
|
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Munz M,
|
||
Dommisch H,
|
||
Schaefer AS,
|
||
Han F,
|
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Ollila HM,
|
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Hillary RP,
|
||
Albagha O,
|
||
Ralston SH,
|
||
Zeng C,
|
||
Zheng W,
|
||
Shu XO,
|
||
Reis A,
|
||
Uebe S,
|
||
Hüffmeier U,
|
||
Kawamura Y,
|
||
Otowa T,
|
||
Sasaki T,
|
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Hibberd ML,
|
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Davila S,
|
||
Xie G,
|
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Siminovitch K,
|
||
Bei JX,
|
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Zeng YX,
|
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Försti A,
|
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Chen B,
|
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Landi S,
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Franke A,
|
||
Fischer A,
|
||
Ellinghaus D,
|
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Flores C,
|
||
Noth I,
|
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Ma SF,
|
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Foo JN,
|
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Liu J,
|
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Kim JW,
|
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Cox DG,
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Delattre O,
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Mirabeau O,
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Skibola CF,
|
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Tang CS,
|
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Garcia-Barcelo M,
|
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Chang KP,
|
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Su WH,
|
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Chang YS,
|
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Martin NG,
|
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Gordon S,
|
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Wade TD,
|
||
Lee C,
|
||
Kubo M,
|
||
Cha PC,
|
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Nakamura Y,
|
||
Levy D,
|
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Kimura M,
|
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Hwang SJ,
|
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Hunt S,
|
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Spector T,
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Soranzo N,
|
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Manichaikul AW,
|
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Barr RG,
|
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Kahali B,
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Speliotes E,
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Yerges-Armstrong LM,
|
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Cheng CY,
|
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Jonas JB,
|
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Wong TY,
|
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Fogh I,
|
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Lin K,
|
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Powell JF,
|
||
Rice K,
|
||
Relton CL,
|
||
Martin RM,
|
||
Davey Smith G</span><br />
|
||
<span class="medgenPMjournal">JAMA Oncol</span>
|
||
2017 May 1;3(5):636-651.
|
||
doi: 10.1001/jamaoncol.2016.5945.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28241208" target="_blank">28241208</a><a href="/pmc/articles/PMC5638008" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21343878">Grading of gliomas: the road from eminence to evidence.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kros JM</span><br />
|
||
<span class="medgenPMjournal">J Neuropathol Exp Neurol</span>
|
||
2011 Feb;70(2):101-9.
|
||
doi: 10.1097/NEN.0b013e31820681aa.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21343878" target="_blank">21343878</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%202%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (459)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34468231">Association Between LIN28A Gene Polymorphisms and Glioma Susceptibility in Chinese Children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guo H,
|
||
Liao Y,
|
||
Lin A,
|
||
Lin H,
|
||
Huang X,
|
||
Ruan J,
|
||
Yuan L,
|
||
Zhuo Z</span><br />
|
||
<span class="medgenPMjournal">Cancer Control</span>
|
||
2021 Jan-Dec;28:10732748211040009.
|
||
doi: 10.1177/10732748211040009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34468231" target="_blank">34468231</a><a href="/pmc/articles/PMC8414609" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30544362">Impact of the H3K27M mutation on survival in pediatric high-grade glioma: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lu VM,
|
||
Alvi MA,
|
||
McDonald KL,
|
||
Daniels DJ</span><br />
|
||
<span class="medgenPMjournal">J Neurosurg Pediatr</span>
|
||
2019 Mar 1;23(3):308-316.
|
||
Epub 2018 Nov 30
|
||
doi: 10.3171/2018.9.PEDS18419.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30544362" target="_blank">30544362</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29414139">IDH1 mutation is associated with a higher preoperative seizure incidence in low-grade glioma: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Li Y,
|
||
Shan X,
|
||
Wu Z,
|
||
Wang Y,
|
||
Ling M,
|
||
Fan X</span><br />
|
||
<span class="medgenPMjournal">Seizure</span>
|
||
2018 Feb;55:76-82.
|
||
Epub 2018 Jan 31
|
||
doi: 10.1016/j.seizure.2018.01.011.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29414139" target="_blank">29414139</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27055523">Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu K,
|
||
Jiang Y</span><br />
|
||
<span class="medgenPMjournal">Cell Mol Neurobiol</span>
|
||
2017 Mar;37(2):263-274.
|
||
Epub 2016 Apr 7
|
||
doi: 10.1007/s10571-016-0367-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27055523" target="_blank">27055523</a><a href="/pmc/articles/PMC11482202" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23975366">Association between GSTP1 Ile105Val polymorphism and glioma risk: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie P,
|
||
Liang Y,
|
||
Liang G,
|
||
Liu B</span><br />
|
||
<span class="medgenPMjournal">Tumour Biol</span>
|
||
2014 Jan;35(1):493-9.
|
||
Epub 2013 Aug 23
|
||
doi: 10.1007/s13277-013-1069-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23975366" target="_blank">23975366</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%202%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (15)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C2751642%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (62)</a></li>
|
||
<li><a href="/gtr/tests?term=C2751642%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C2751642%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (5)</a></li>
|
||
<li><a href="/gtr/tests?term=C2751642%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (58)</a></li>
|
||
<li><a href="/gtr/tests?term=C2751642%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (4)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C2751642%5bDISCUI%5d" target="_blank">See all (72)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=613028" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Glioma%20susceptibility%202" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(glioma%20susceptibility%202)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=601728" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=5728[geneid]" target="_blank">View PTEN variations in ClinVar</a></li><li><a href="/nuccore/170650628" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=613028" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Glioma+susceptibility+2/8469" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/glioma_susceptibility_2" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Glioma%20susceptibility%202" target="_blank">MedlinePlus</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Glioma%20susceptibility%202" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Glioma%20susceptibility%202%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=414431" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=414431" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C2751642[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C2751642[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=414431" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim_gene&from_uid=414431" ref="log$=recordlinks">OMIM(Genes)</a>
|
||
<div class="brieflinkpop offscreen_noflow">OMIM records containing genes associated with phenotypes registered in MedGen</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pmc?LinkName=medgen_pmc&from_uid=414431" ref="log$=recordlinks">PMC Articles</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in PubMed Central Links</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed&from_uid=414431" ref="log$=recordlinks">PubMed</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/pubmed?LinkName=medgen_pubmed_omim&from_uid=414431" ref="log$=recordlinks">PubMed (OMIM)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related literature resources in PubMed</div>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
|
||
<div class="portlet">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Recent activity</h3>
|
||
</div>
|
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<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="recent_activity" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Shutter"></a>
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</div>
|
||
<div class="portlet_content">
|
||
<div id="HTDisplay" class="">
|
||
<input name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.HistoryDisplay.Cmd" sid="1" type="hidden" />
|
||
<div class="action">
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<li>
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<a class="text-white" href="https://www.usa.gov/">USA.gov</a>
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