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<meta name="keywords" content="C2750850, astrocytoma, ependymoma, erbb2, finding, glioblastoma multiforme, glioblastoma, somatic, glioma of brain, familial, glioma susceptibility 1, glioma susceptibility 1, autosomal dominant, somatic mutation, glioma, susceptibility to, somatic, glm1, idh1, oligodendroglioma, subependymoma, tp53, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, ependymomas, and subependymomas. Glial cells can show various degrees of differentiation even within the same tumor (summary by Kyritsis et al., 2010). Ependymomas are rare glial tumors of the brain and spinal cord (Yokota et al., 2003). Subependymomas are unusual tumors believed to arise from the bipotential subependymal cell, which normally differentiates into either ependymal cells or astrocytes. They were characterized as a distinct entity by Scheinker (1945). They tend to be slow-growing, noninvasive, and located in the ventricular system, septum pellucidum, cerebral aqueduct, or proximal spinal cord (summary by Ryken et al., 1994). Gliomas are known to occur in association with several other well-defined hereditary tumor syndromes such as mismatch repair cancer syndrome (see 276300), melanoma-astrocytoma syndrome (155755), neurofibromatosis-1 (NF1; 162200) and neurofibromatosis-2 (see SWNV, 101000), and tuberous sclerosis (TSC1; 191100). Familial clustering of gliomas may occur in the absence of these tumor syndromes, however. Genetic Heterogeneity of Susceptibility to Glioma Other glioma susceptibilities include GLM2 (613028), caused by variation in the PTEN gene (601728) on chromosome 10q23; GLM3 (613029), caused by variation in the BRCA2 gene (600185) on chromosome 13q13; GLM4 (607248), mapped to chromosome 15q23-q26.3; GLM5 (613030), mapped to chromosome 9p21; GLM6 (613031), mapped to chromosome 20q13; GLM7 (613032), mapped to chromosome 8q24; GLM8 (613033), mapped to chromosome 5p15; and GLM9, caused by variation in the POT1 gene (606478) on chromosome 7q31. Somatic mutation, disruption, or copy number variation of the following genes or loci may also contribute to the formation of glioma: ERBB (EGFR; 131550), ERBB2 (164870), LGI1 (604619), GAS41 (602116), GLI (165220), DMBT1 (601969), IDH1 (147700), IDH2 (147650), BRAF (164757), PARK2 (602544), TP53 (191170), RB1 (614041), PIK3CA (171834), 10p15, 19q, and 17p13.3." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=413414
|
||
ConceptID=C2750850
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Glioma susceptibility 1<span class="h1sub">(GLM1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>413414</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2750850</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Glioblastoma, somatic; GLM1</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="ERBB2 - ID: 2064 - NCBI Gene" href="/gene/2064" class="medgenPMinfo">ERBB2</a> (17q12); <a target="_blank" title="IDH1 - ID: 3417 - NCBI Gene" href="/gene/3417" class="medgenPMinfo">IDH1</a> (2q34); <a target="_blank" title="TP53 - ID: 7157 - NCBI Gene" href="/gene/7157" class="medgenPMinfo">TP53</a> (17p13.1)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0024498" target="_blank">MONDO:0024498</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/137800" target="_blank">137800</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, ependymomas, and subependymomas. Glial cells can show various degrees of differentiation even within the same tumor (summary by Kyritsis et al., 2010). Ependymomas are rare glial tumors of the brain and spinal cord (Yokota et al., 2003). Subependymomas are unusual tumors believed to arise from the bipotential subependymal cell, which normally differentiates into either ependymal cells or astrocytes. They were characterized as a distinct entity by Scheinker (1945). They tend to be slow-growing, noninvasive, and located in the ventricular system, septum pellucidum, cerebral aqueduct, or proximal spinal cord (summary by Ryken et al., 1994). Gliomas are known to occur in association with several other well-defined hereditary tumor syndromes such as mismatch repair cancer syndrome (see 276300), melanoma-astrocytoma syndrome (155755), neurofibromatosis-1 (NF1; 162200) and neurofibromatosis-2 (see SWNV, 101000), and tuberous sclerosis (TSC1; 191100). Familial clustering of gliomas may occur in the absence of these tumor syndromes, however. Genetic Heterogeneity of Susceptibility to Glioma Other glioma susceptibilities include GLM2 (613028), caused by variation in the PTEN gene (601728) on chromosome 10q23; GLM3 (613029), caused by variation in the BRCA2 gene (600185) on chromosome 13q13; GLM4 (607248), mapped to chromosome 15q23-q26.3; GLM5 (613030), mapped to chromosome 9p21; GLM6 (613031), mapped to chromosome 20q13; GLM7 (613032), mapped to chromosome 8q24; GLM8 (613033), mapped to chromosome 5p15; and GLM9, caused by variation in the POT1 gene (606478) on chromosome 7q31. Somatic mutation, disruption, or copy number variation of the following genes or loci may also contribute to the formation of glioma: ERBB (EGFR; 131550), ERBB2 (164870), LGI1 (604619), GAS41 (602116), GLI (165220), DMBT1 (601969), IDH1 (147700), IDH2 (147650), BRAF (164757), PARK2 (602544), TP53 (191170), RB1 (614041), PIK3CA (171834), 10p15, 19q, and 17p13.3. [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_438"><div><strong>Astrocytoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>438</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0004114</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Astrocytoma is a neoplasm of the central nervous system derived from astrocytes. Astrocytes are a type of glial cell, and thus astrocytoma is a subtype of glioma.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/438">Feature record</a> | <a href="/medgen?term=%22Astrocytoma%22%5BClinical%20Features%5D%20OR%20438%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_41825"><div><strong>Ependymoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>41825</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0014474</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of an ependymoma of the central nervous system.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/41825">Feature record</a> | <a href="/medgen?term=%22Ependymoma%22%5BClinical%20Features%5D%20OR%2041825%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_301585"><div><strong>Glioblastoma multiforme</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>301585</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1621958</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A tumor arising from glia in the central nervous system with macroscopic regions of necrosis and hemorrhage. Microscopically, glioblastoma multiforme is characterized by regions of pseudopalisading necrosis, pleomorphic nuclei and cells, and microvascular proliferation.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/301585">Feature record</a> | <a href="/medgen?term=%22Glioblastoma%20multiforme%22%5BClinical%20Features%5D%20OR%20301585%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Abnormality of the nervous system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_438" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Astrocytoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_41825" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Ependymoma</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_301585" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Glioblastoma multiforme</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0017638[DISCUI]&test_type=Clinical" ref="ncbi_uid=9030">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9030" ref="ncbi_uid=9030">V</a></span></span><span class="TLline"><a href="/medgen/9030" ref="tree=GTR&ncbi_uid=9030&link_uid=9030" title="View MedGen record for 'Glioma'">Glioma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0004114[DISCUI]&test_type=Clinical" ref="ncbi_uid=438">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=438" target="_blank" href="/omim/137800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=438" ref="ncbi_uid=438">V</a></span></span><span class="TLline"><a href="/medgen/438" ref="tree=GTR&ncbi_uid=438&link_uid=438" title="View MedGen record for 'Astrocytoma'">Astrocytoma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0017636[DISCUI]&test_type=Clinical" ref="ncbi_uid=42228">C</a></span><span class="chiclet Rcolor round" title="Research test"><a target="_blank" href="/gtr/tests/?term=C0017636[DISCUI]&test_type=Research&redirect=true" ref="ncbi_uid=42228">R</a></span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=42228" ref="ncbi_uid=42228">V</a></span></span><span class="TLline"><a href="/medgen/42228" ref="tree=GTR&ncbi_uid=42228&link_uid=42228" title="View MedGen record for 'Glioblastoma'">Glioblastoma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0014474[DISCUI]&test_type=Clinical" ref="ncbi_uid=41825">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=41825" target="_blank" href="/omim/137800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=41825" ref="ncbi_uid=41825">V</a></span></span><span class="TLline"><a href="/medgen/41825" ref="tree=GTR&ncbi_uid=41825&link_uid=41825" title="View MedGen record for 'Ependymoma'">Ependymoma</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=64637" target="_blank" href="/omim/137800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/64637" ref="tree=GTR&ncbi_uid=64637&link_uid=64637" title="View MedGen record for 'Subependymal glioma'">Subependymal glioma</a></span></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=CN305335[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=986435">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/986435" ref="tree=GTR&ncbi_uid=986435&link_uid=986435" title="View MedGen record for 'Glioma susceptibility'">Glioma susceptibility</a></span></li><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2750850[DISCUI]&test_type=Clinical" ref="ncbi_uid=413414">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=413414" target="_blank" href="/omim/137800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=413414" ref="ncbi_uid=413414">V</a></span></span><span class="TLline">Glioma susceptibility 1</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0025149[DISCUI]&test_type=Clinical" ref="ncbi_uid=7517">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=7517" target="_blank" href="/omim/155255">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=7517" ref="ncbi_uid=7517">V</a></span></span><span class="TLline"><a href="/medgen/7517" ref="tree=GTR&ncbi_uid=7517&link_uid=7517" title="View MedGen record for 'Medulloblastoma'">Medulloblastoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0547065[DISCUI]&test_type=Clinical" ref="ncbi_uid=154285">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/154285" ref="tree=GTR&ncbi_uid=154285&link_uid=154285" title="View MedGen record for 'Oligoastrocytoma'">Oligoastrocytoma</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0028945[DISCUI]&test_type=Clinical" ref="ncbi_uid=45190">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=45190" target="_blank" href="/omim/137800">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=45190" ref="ncbi_uid=45190">V</a></span></span><span class="TLline"><a href="/medgen/45190" ref="tree=GTR&ncbi_uid=45190&link_uid=45190" title="View MedGen record for 'Oligodendroglioma'">Oligodendroglioma</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/14297" ref="tree=MeSH" title="MedGen record for Malignant neoplastic disease">Malignant neoplastic disease</a></span><ul><li><span class="TLline"><a href="/medgen/99231" ref="tree=MeSH" title="MedGen record for Malignant neoplasm of nervous system">Malignant neoplasm of nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/87593" ref="tree=MeSH" title="MedGen record for Malignant neoplasm of the central nervous system">Malignant neoplasm of the central nervous system</a></span><ul><li><span class="TLline"><a href="/medgen/9030" ref="tree=MeSH" title="MedGen record for Glioma">Glioma</a></span><ul><li><span class="matched_ds">Glioma susceptibility 1</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/29315108">Review of molecular classification and treatment implications of pediatric brain tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guerreiro Stucklin AS,
|
||
Ramaswamy V,
|
||
Daniels C,
|
||
Taylor MD</span><br />
|
||
<span class="medgenPMjournal">Curr Opin Pediatr</span>
|
||
2018 Feb;30(1):3-9.
|
||
doi: 10.1097/MOP.0000000000000562.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29315108" target="_blank">29315108</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28339748">Genotype-based gene signature of glioma risk.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Huang YT,
|
||
Zhang Y,
|
||
Wu Z,
|
||
Michaud DS</span><br />
|
||
<span class="medgenPMjournal">Neuro Oncol</span>
|
||
2017 Jul 1;19(7):940-950.
|
||
doi: 10.1093/neuonc/now288.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28339748" target="_blank">28339748</a><a href="/pmc/articles/PMC5737684" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25727224">Molecular features assisting in diagnosis, surgery, and treatment decision making in low-grade gliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chen R,
|
||
Ravindra VM,
|
||
Cohen AL,
|
||
Jensen RL,
|
||
Salzman KL,
|
||
Prescot AP,
|
||
Colman H</span><br />
|
||
<span class="medgenPMjournal">Neurosurg Focus</span>
|
||
2015 Mar;38(3):E2.
|
||
doi: 10.3171/2015.1.FOCUS14745.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25727224" target="_blank">25727224</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(glioma%20susceptibility%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (74)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31957502">Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tavares CB,
|
||
Gomes-Braga FDCSA,
|
||
Sousa EB,
|
||
Brito JNPO,
|
||
Melo MA,
|
||
Campelo V,
|
||
Neto FM,
|
||
de Araújo RML,
|
||
Kessler IM,
|
||
Sousa Júnior LM,
|
||
Filho LCC,
|
||
Aguiar YQ,
|
||
Lopes Costa PV,
|
||
da Silva BB</span><br />
|
||
<span class="medgenPMjournal">Cancer Invest</span>
|
||
2020 Mar;38(3):169-183.
|
||
Epub 2020 Mar 2
|
||
doi: 10.1080/07357907.2020.1719502.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31957502" target="_blank">31957502</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29548059">Gliomas in Children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Filbin MG,
|
||
Sturm D</span><br />
|
||
<span class="medgenPMjournal">Semin Neurol</span>
|
||
2018 Feb;38(1):121-130.
|
||
Epub 2018 Mar 16
|
||
doi: 10.1055/s-0038-1635106.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29548059" target="_blank">29548059</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29548046">Origin of Gliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cahill D,
|
||
Turcan S</span><br />
|
||
<span class="medgenPMjournal">Semin Neurol</span>
|
||
2018 Feb;38(1):5-10.
|
||
Epub 2018 Mar 16
|
||
doi: 10.1055/s-0037-1620238.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29548046" target="_blank">29548046</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29241168">Epidemiology of Intracranial Gliomas.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ostrom QT,
|
||
Gittleman H,
|
||
Stetson L,
|
||
Virk S,
|
||
Barnholtz-Sloan JS</span><br />
|
||
<span class="medgenPMjournal">Prog Neurol Surg</span>
|
||
2018;30:1-11.
|
||
Epub 2017 Dec 14
|
||
doi: 10.1159/000464374.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29241168" target="_blank">29241168</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28346443">Genome-wide association study of glioma subtypes identifies specific differences in genetic susceptibility to glioblastoma and non-glioblastoma tumors.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Melin BS,
|
||
Barnholtz-Sloan JS,
|
||
Wrensch MR,
|
||
Johansen C,
|
||
Il'yasova D,
|
||
Kinnersley B,
|
||
Ostrom QT,
|
||
Labreche K,
|
||
Chen Y,
|
||
Armstrong G,
|
||
Liu Y,
|
||
Eckel-Passow JE,
|
||
Decker PA,
|
||
Labussière M,
|
||
Idbaih A,
|
||
Hoang-Xuan K,
|
||
Di Stefano AL,
|
||
Mokhtari K,
|
||
Delattre JY,
|
||
Broderick P,
|
||
Galan P,
|
||
Gousias K,
|
||
Schramm J,
|
||
Schoemaker MJ,
|
||
Fleming SJ,
|
||
Herms S,
|
||
Heilmann S,
|
||
Nöthen MM,
|
||
Wichmann HE,
|
||
Schreiber S,
|
||
Swerdlow A,
|
||
Lathrop M,
|
||
Simon M,
|
||
Sanson M,
|
||
Andersson U,
|
||
Rajaraman P,
|
||
Chanock S,
|
||
Linet M,
|
||
Wang Z,
|
||
Yeager M;
|
||
GliomaScan Consortium,
|
||
Wiencke JK,
|
||
Hansen H,
|
||
McCoy L,
|
||
Rice T,
|
||
Kosel ML,
|
||
Sicotte H,
|
||
Amos CI,
|
||
Bernstein JL,
|
||
Davis F,
|
||
Lachance D,
|
||
Lau C,
|
||
Merrell RT,
|
||
Shildkraut J,
|
||
Ali-Osman F,
|
||
Sadetzki S,
|
||
Scheurer M,
|
||
Shete S,
|
||
Lai RK,
|
||
Claus EB,
|
||
Olson SH,
|
||
Jenkins RB,
|
||
Houlston RS,
|
||
Bondy ML</span><br />
|
||
<span class="medgenPMjournal">Nat Genet</span>
|
||
2017 May;49(5):789-794.
|
||
Epub 2017 Mar 27
|
||
doi: 10.1038/ng.3823.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28346443" target="_blank">28346443</a><a href="/pmc/articles/PMC5558246" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%201%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (804)</a></div><h3 class="subhead">Diagnosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/31806884">Altered cellular metabolism in gliomas - an emerging landscape of actionable co-dependency targets.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31718568">System-based approaches as prognostic tools for glioblastoma.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26688373">Insights into cerebellar development and medulloblastoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bihannic L,
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<div class="nl"><a target="_blank" href="/pubmed/12432832">Neurofibromatosis 1.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%201%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (652)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/39375303">Vorasidenib: First Approval.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lamb YN</span><br />
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<div class="nl"><a target="_blank" href="/pubmed/34557553">New Immunotherapeutic Approaches for Glioblastoma.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/31806885">Brain immunology and immunotherapy in brain tumours.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Sampson JH,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%201%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (246)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/35135556">Glioma targeted therapy: insight into future of molecular approaches.</a></div>
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Wu Z,
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Zhang H,
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<div class="nl"><a target="_blank" href="/pubmed/35031058">EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Pan Z,
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Zhao R,
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<div class="nl"><a target="_blank" href="/pubmed/31678207">A review of recently described genetic alterations in central nervous system tumors.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26688373">Insights into cerebellar development and medulloblastoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Bihannic L,
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<span class="bold">PMID: </span><a href="/pubmed/26688373" target="_blank">26688373</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%201%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (483)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/32620889">Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.</a></div>
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Wiklund F;
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Breast Cancer Association Consortium (BCAC);
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Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON);
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Colon Cancer Family Registry (CCFR);
|
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Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT);
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Endometrial Cancer Association Consortium (ECAC);
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Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO);
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Melanoma Genetics Consortium (GenoMEL);
|
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Glioma International Case-Control Study (GICC);
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International Lung Cancer Consortium (ILCCO);
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Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Consortium;
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International Consortium of Investigators Working on Non-Hodgkin’s Lymphoma Epidemiologic Studies (InterLymph);
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Ovarian Cancer Association Consortium (OCAC);
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Oral Cancer GWAS;
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Pancreatic Cancer Case-Control Consortium (PanC4);
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Pancreatic Cancer Cohort Consortium (PanScan);
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Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL);
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Renal Cancer GWAS;
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Testicular Cancer Consortium (TECAC),
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<div class="nl"><a target="_blank" href="/pubmed/31678207">A review of recently described genetic alterations in central nervous system tumors.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lucas CG,
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Hain M,
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||
Zichner T,
|
||
Segura-Wang M,
|
||
Weischenfeldt J,
|
||
Rausch T,
|
||
Mardin BR,
|
||
Zhou X,
|
||
Baciu C,
|
||
Lawerenz C,
|
||
Chan JA,
|
||
Varlet P,
|
||
Guerrini-Rousseau L,
|
||
Fults DW,
|
||
Grajkowska W,
|
||
Hauser P,
|
||
Jabado N,
|
||
Ra YS,
|
||
Zitterbart K,
|
||
Shringarpure SS,
|
||
De La Vega FM,
|
||
Bustamante CD,
|
||
Ng HK,
|
||
Perry A,
|
||
MacDonald TJ,
|
||
Hernáiz Driever P,
|
||
Bendel AE,
|
||
Bowers DC,
|
||
McCowage G,
|
||
Chintagumpala MM,
|
||
Cohn R,
|
||
Hassall T,
|
||
Fleischhack G,
|
||
Eggen T,
|
||
Wesenberg F,
|
||
Feychting M,
|
||
Lannering B,
|
||
Schüz J,
|
||
Johansen C,
|
||
Andersen TV,
|
||
Röösli M,
|
||
Kuehni CE,
|
||
Grotzer M,
|
||
Kjaerheim K,
|
||
Monoranu CM,
|
||
Archer TC,
|
||
Duke E,
|
||
Pomeroy SL,
|
||
Shelagh R,
|
||
Frank S,
|
||
Sumerauer D,
|
||
Scheurlen W,
|
||
Ryzhova MV,
|
||
Milde T,
|
||
Kratz CP,
|
||
Samuel D,
|
||
Zhang J,
|
||
Solomon DA,
|
||
Marra M,
|
||
Eils R,
|
||
Bartram CR,
|
||
von Hoff K,
|
||
Rutkowski S,
|
||
Ramaswamy V,
|
||
Gilbertson RJ,
|
||
Korshunov A,
|
||
Taylor MD,
|
||
Lichter P,
|
||
Malkin D,
|
||
Gajjar A,
|
||
Korbel JO,
|
||
Pfister SM</span><br />
|
||
<span class="medgenPMjournal">Lancet Oncol</span>
|
||
2018 Jun;19(6):785-798.
|
||
Epub 2018 May 9
|
||
doi: 10.1016/S1470-2045(18)30242-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29753700" target="_blank">29753700</a><a href="/pmc/articles/PMC5984248" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26337759">Melanoma genetics.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Read J,
|
||
Wadt KA,
|
||
Hayward NK</span><br />
|
||
<span class="medgenPMjournal">J Med Genet</span>
|
||
2016 Jan;53(1):1-14.
|
||
Epub 2015 Sep 3
|
||
doi: 10.1136/jmedgenet-2015-103150.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26337759" target="_blank">26337759</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%201%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (569)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/34468231">Association Between LIN28A Gene Polymorphisms and Glioma Susceptibility in Chinese Children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guo H,
|
||
Liao Y,
|
||
Lin A,
|
||
Lin H,
|
||
Huang X,
|
||
Ruan J,
|
||
Yuan L,
|
||
Zhuo Z</span><br />
|
||
<span class="medgenPMjournal">Cancer Control</span>
|
||
2021 Jan-Dec;28:10732748211040009.
|
||
doi: 10.1177/10732748211040009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34468231" target="_blank">34468231</a><a href="/pmc/articles/PMC8414609" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32493226">Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Howell AE,
|
||
Robinson JW,
|
||
Wootton RE,
|
||
McAleenan A,
|
||
Tsavachidis S,
|
||
Ostrom QT,
|
||
Bondy M,
|
||
Armstrong G,
|
||
Relton C,
|
||
Haycock P,
|
||
Martin RM,
|
||
Zheng J,
|
||
Kurian KM</span><br />
|
||
<span class="medgenPMjournal">BMC Cancer</span>
|
||
2020 Jun 3;20(1):508.
|
||
doi: 10.1186/s12885-020-06967-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32493226" target="_blank">32493226</a><a href="/pmc/articles/PMC7268455" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31957502">Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tavares CB,
|
||
Gomes-Braga FDCSA,
|
||
Sousa EB,
|
||
Brito JNPO,
|
||
Melo MA,
|
||
Campelo V,
|
||
Neto FM,
|
||
de Araújo RML,
|
||
Kessler IM,
|
||
Sousa Júnior LM,
|
||
Filho LCC,
|
||
Aguiar YQ,
|
||
Lopes Costa PV,
|
||
da Silva BB</span><br />
|
||
<span class="medgenPMjournal">Cancer Invest</span>
|
||
2020 Mar;38(3):169-183.
|
||
Epub 2020 Mar 2
|
||
doi: 10.1080/07357907.2020.1719502.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31957502" target="_blank">31957502</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/27055523">Polymorphisms in DNA Repair Gene and Susceptibility to Glioma: A Systematic Review and Meta-Analysis Based on 33 Studies with 15 SNPs in 9 Genes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Liu K,
|
||
Jiang Y</span><br />
|
||
<span class="medgenPMjournal">Cell Mol Neurobiol</span>
|
||
2017 Mar;37(2):263-274.
|
||
Epub 2016 Apr 7
|
||
doi: 10.1007/s10571-016-0367-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/27055523" target="_blank">27055523</a><a href="/pmc/articles/PMC11482202" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23975366">Association between GSTP1 Ile105Val polymorphism and glioma risk: a systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Xie P,
|
||
Liang Y,
|
||
Liang G,
|
||
Liu B</span><br />
|
||
<span class="medgenPMjournal">Tumour Biol</span>
|
||
2014 Jan;35(1):493-9.
|
||
Epub 2013 Aug 23
|
||
doi: 10.1007/s13277-013-1069-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23975366" target="_blank">23975366</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Glioma%20susceptibility%201%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (19)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
|
||
<div class="rightCol mgCol">
|
||
<div class="portlet mgSection" id="ID_113">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul id="my-toc"></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_106">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C2750850%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (48)</a></li>
|
||
<li><a href="/gtr/tests?term=C2750850%5bDISCUI%5d&filter=method%3A3%5F31" target="_blank">Fluorescence in situ hybridization (FISH) (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C2750850%5bDISCUI%5d&filter=method%3A2%5F15" target="_blank">Methylation analysis (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C2750850%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (3)</a></li>
|
||
<li><a href="/gtr/tests?term=C2750850%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (11)</a></li>
|
||
<li><a href="/gtr/tests?term=C2750850%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (44)</a></li>
|
||
<li><a href="/gtr/tests?term=C2750850%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (7)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C2750850%5bDISCUI%5d" target="_blank">See all (71)</a></total></li>
|
||
</ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_119">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=137800" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Glioma%20susceptibility%201" target="_blank">ClinicalTrials.gov</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_121">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(glioma%20susceptibility%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_115">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=147700%20164870%20191170" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=2064[geneid]" target="_blank">View ERBB2 variations in ClinVar</a></li><li><a href="/clinvar/?term=3417[geneid]" target="_blank">View IDH1 variations in ClinVar</a></li><li><a href="/clinvar/?term=7157[geneid]" target="_blank">View TP53 variations in ClinVar</a></li><li><a href="/nuccore/171906587,293651587,300244504" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=137800" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_116">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><ul><li><a href="http://www.diseaseinfosearch.org/Glioma+susceptibility+1/8468" target="_blank">Genetic Alliance</a></li><li><a href="https://www.malacards.org/card/glioma_susceptibility_1" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Glioma%20susceptibility%201" target="_blank">MedlinePlus</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Reviews</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="Reviews" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenReviews.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content">
|
||
<ul>
|
||
<li>
|
||
<a href="/pubmed/clinical?term=Glioma%20susceptibility%201" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Glioma%20susceptibility%201%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
|
||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
|
||
<div class="portlet_title">
|
||
<h3>Related information</h3>
|
||
</div>
|
||
<a name="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter" sid="1" href="#" class="portlet_shutter" title="Show/hide content" remembercollapsed="true" pgsec_name="discovery_db_links" id="EntrezSystem2.PEntrez.MedGen.MedGen_ResultsPanel.MedGen_SingleItemSuplCluster.MedGenDiscoveryDbLinks.Shutter"></a>
|
||
</div>
|
||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=413414" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=413414" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C2750850[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C2750850[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
<div class="brieflinkpop offscreen_noflow">Clinical tests in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/omim?LinkName=medgen_omim&from_uid=413414" ref="log$=recordlinks">OMIM</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related records in OMIM</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
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<a href="https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323" class="text-white" target="_blank" rel="noopener noreferrer">8600 Rockville Pike<br />
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Bethesda, MD 20894</a></p>
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<p><a href="https://www.nlm.nih.gov/web_policies.html" class="text-white">Web Policies</a><br />
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