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<meta name="keywords" content="C2749757, besc1, bronchiectasis with or without elevated sweat chloride 1, bronchiectasis with or without elevated sweat chloride 1, modifier of, bronchiectasis with or without elevated sweat chloride type 1, cftr, cystic fibrosis-like syndrome, disease or syndrome, non-classic cystic fibrosis-like syndrome, scnn1b, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Bronchiectasis with or without elevated sweat chloride-1 (BESC1) is characterized by dilation of the airways arising from chronic bronchial inflammation accompanied by chronic cough, purulent sputum, and recurrent respiratory tract infections. Severity is variable, and some patients may be identified in adulthood and have normal respiratory function (Sheridan et al., 2005, Fajac et al., 2008). Genetic Heterogeneity of Bronchiectasis with or without Elevated Sweat Chloride Bronchiectasis with or without elevated sweat chloride-2 (BESC2; 613021) is caused by mutation in the gene encoding the alpha subunit of the epithelial sodium channel (SCNN1A; 600228) on chromosome 12p13, and BESC3 (613071) is caused by mutation in the gene encoding the gamma subunit (SCNN1G; 600761) on chromosome 16p12. Bronchiectasis and elevated sweat chloride associated with pancreatic exocrine dysfunction and infertility are also features of cystic fibrosis (CF; 219700), which is caused by mutation in the CFTR gene (602421)." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=440868
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ConceptID=C2749757
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Bronchiectasis with or without elevated sweat chloride 1<span class="h1sub">(BESC1)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>440868</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C2749757</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>BESC1; Cystic Fibrosis-Like Syndrome; Non-Classic Cystic Fibrosis-Like Syndrome</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Genes (locations):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="CFTR - ID: 1080 - NCBI Gene" href="/gene/1080" class="medgenPMinfo">CFTR</a> (7q31.2); <a target="_blank" title="SCNN1B - ID: 6338 - NCBI Gene" href="/gene/6338" class="medgenPMinfo">SCNN1B</a> (16p12.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0008887" target="_blank">MONDO:0008887</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/211400" target="_blank">211400</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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||
<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Bronchiectasis with or without elevated sweat chloride-1 (BESC1) is characterized by dilation of the airways arising from chronic bronchial inflammation accompanied by chronic cough, purulent sputum, and recurrent respiratory tract infections. Severity is variable, and some patients may be identified in adulthood and have normal respiratory function (Sheridan et al., 2005, Fajac et al., 2008). Genetic Heterogeneity of Bronchiectasis with or without Elevated Sweat Chloride Bronchiectasis with or without elevated sweat chloride-2 (BESC2; 613021) is caused by mutation in the gene encoding the alpha subunit of the epithelial sodium channel (SCNN1A; 600228) on chromosome 12p13, and BESC3 (613071) is caused by mutation in the gene encoding the gamma subunit (SCNN1G; 600761) on chromosome 16p12. Bronchiectasis and elevated sweat chloride associated with pancreatic exocrine dysfunction and infertility are also features of cystic fibrosis (CF; 219700), which is caused by mutation in the CFTR gene (602421). [from <a title="Online Mendelian Inheritance in Man" href="http://www.omim.org" class="defSource" target="_blank">OMIM</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_866753"><div><strong>Abnormality of exocrine pancreas physiology</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>866753</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4021103</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Pathologic Function</dd></dl></div></div></div>
|
||
<div class="spaceAbove">A functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/866753">Feature record</a> | <a href="/medgen?term=%22Abnormality%20of%20exocrine%20pancreas%20physiology%22%5BClinical%20Features%5D%20OR%20866753%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_14234"><div><strong>Bronchiectasis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>14234</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0006267</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/14234">Feature record</a> | <a href="/medgen?term=%22Bronchiectasis%22%5BClinical%20Features%5D%20OR%2014234%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_3084"><div><strong>Chronic bronchitis</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>3084</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0008677</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Chronic inflammation of the bronchi.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/3084">Feature record</a> | <a href="/medgen?term=%22Chronic%20bronchitis%22%5BClinical%20Features%5D%20OR%203084%5Buid%5D">Search on this feature</a></div></div>
|
||
<div class="divPopper rprt" id="clin_347278"><div><strong>Elevated sweat chloride</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>347278</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1856646</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">An increased concentration of chloride in the sweat.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/347278">Feature record</a> | <a href="/medgen?term=%22Elevated%20sweat%20chloride%22%5BClinical%20Features%5D%20OR%20347278%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite" data-jigconfig="closed: 1"><div class="concept-def"><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().openAll(); return false;">Show all</a><a class="small" href="#" onclick="jQuery(".TreeLite","#ID_102").TreeLite().closeAll(); return false;">Hide all</a></div><ul><li><span class="TLline">Abnormality of metabolism/homeostasis</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_347278" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Elevated sweat chloride</a></span></li></ul></li><li><span class="TLline">Abnormality of the digestive system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_866753" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Abnormality of exocrine pancreas physiology</a></span></li></ul></li><li><span class="TLline">Abnormality of the respiratory system</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_14234" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Bronchiectasis</a></span></li><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_3084" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chronic bronchitis</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0024117[DISCUI]&test_type=Clinical" ref="ncbi_uid=9818">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=9818" target="_blank" href="/omim/606963">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9818" ref="ncbi_uid=9818">V</a></span></span><span class="TLline"><a href="/medgen/9818" ref="tree=GTR&ncbi_uid=9818&link_uid=9818" title="View MedGen record for 'Chronic obstructive pulmonary disease'">Chronic obstructive pulmonary disease</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0006267[DISCUI]&test_type=Clinical&redirect=true" ref="ncbi_uid=14234">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=14234" ref="ncbi_uid=14234">V</a></span></span><span class="TLline"><a href="/medgen/14234" ref="tree=GTR&ncbi_uid=14234&link_uid=14234" title="View MedGen record for 'Bronchiectasis'">Bronchiectasis</a></span><ul><li class="TLclosed"><span class="TLline"><a href="/medgen/573462" ref="tree=GTR&ncbi_uid=573462&link_uid=573462" title="View MedGen record for 'Idiopathic bronchiectasis'">Idiopathic bronchiectasis</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2749757[DISCUI]&test_type=Clinical" ref="ncbi_uid=440868">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=440868" target="_blank" href="/omim/211400">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=440868" ref="ncbi_uid=440868">V</a></span></span><span class="TLline">Bronchiectasis with or without elevated sweat chloride 1</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751666[DISCUI]&test_type=Clinical" ref="ncbi_uid=414437">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=414437" target="_blank" href="/omim/600228">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=414437" ref="ncbi_uid=414437">V</a></span></span><span class="TLline"><a href="/medgen/414437" ref="tree=GTR&ncbi_uid=414437&link_uid=414437" title="View MedGen record for 'Bronchiectasis with or without elevated sweat chloride 2'">Bronchiectasis with or without elevated sweat chloride 2</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C2751324[DISCUI]&test_type=Clinical" ref="ncbi_uid=414351">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=414351" target="_blank" href="/omim/600761">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=414351" ref="ncbi_uid=414351">V</a></span></span><span class="TLline"><a href="/medgen/414351" ref="tree=GTR&ncbi_uid=414351&link_uid=414351" title="View MedGen record for 'Bronchiectasis with or without elevated sweat chloride 3'">Bronchiectasis with or without elevated sweat chloride 3</a></span></li></ul></li></ul></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0008677[DISCUI]&test_type=Clinical" ref="ncbi_uid=3084">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/3084" ref="tree=GTR&ncbi_uid=3084&link_uid=3084" title="View MedGen record for 'Chronic bronchitis'">Chronic bronchitis</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1847014[DISCUI]&test_type=Clinical" ref="ncbi_uid=376022">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=376022" target="_blank" href="/omim/606963">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=376022" ref="ncbi_uid=376022">V</a></span></span><span class="TLline"><a href="/medgen/376022" ref="tree=GTR&ncbi_uid=376022&link_uid=376022" title="View MedGen record for 'COPD, severe early onset'">COPD, severe early onset</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=163897" target="_blank" href="/omim/604809">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/163897" ref="tree=GTR&ncbi_uid=163897&link_uid=163897" title="View MedGen record for 'Diffuse panbronchiolitis'">Diffuse panbronchiolitis</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0034067[DISCUI]&test_type=Clinical" ref="ncbi_uid=18764">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=18764" ref="ncbi_uid=18764">V</a></span></span><span class="TLline"><a href="/medgen/18764" ref="tree=GTR&ncbi_uid=18764&link_uid=18764" title="View MedGen record for 'Emphysema'">Emphysema</a></span><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/510136" ref="tree=GTR&ncbi_uid=510136&link_uid=510136" title="View MedGen record for 'Compensatory emphysema'">Compensatory emphysema</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=120557" target="_blank" href="/omim/130710">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/120557" ref="tree=GTR&ncbi_uid=120557&link_uid=120557" title="View MedGen record for 'Congenital lobar emphysema'">Congenital lobar emphysema</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=338765" target="_blank" href="/omim/130700">O</a></span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/338765" ref="tree=GTR&ncbi_uid=338765&link_uid=338765" title="View MedGen record for 'Emphysema, hereditary pulmonary'">Emphysema, hereditary pulmonary</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/101178" ref="tree=GTR&ncbi_uid=101178&link_uid=101178" title="View MedGen record for 'Hyperlucent lung'">Hyperlucent lung</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet unavailable round" title="Clinical test">C</span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet unavailable" title="ClinVar">V</span></span><span class="TLline"><a href="/medgen/234586" ref="tree=GTR&ncbi_uid=234586&link_uid=234586" title="View MedGen record for 'Interstitial emphysema'">Interstitial emphysema</a></span></li></ul></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/220360" ref="tree=MeSH" title="MedGen record for Abnormal respiratory system physiology">Abnormal respiratory system physiology</a></span><ul><li><span class="TLline"><a href="/medgen/868593" ref="tree=MeSH" title="MedGen record for Abnormal respiratory system morphology">Abnormal respiratory system morphology</a></span><ul><li><span class="TLline"><a href="/medgen/867271" ref="tree=MeSH" title="MedGen record for Abnormal tracheobronchial morphology">Abnormal tracheobronchial morphology</a></span><ul><li><span class="TLline"><a href="/medgen/1371523" ref="tree=MeSH" title="MedGen record for Abnormal bronchus morphology">Abnormal bronchus morphology</a></span><ul><li><span class="TLline"><a href="/medgen/14234" ref="tree=MeSH" title="MedGen record for Bronchiectasis">Bronchiectasis</a></span><ul><li><span class="TLline"><a href="/medgen/573462" ref="tree=MeSH" title="MedGen record for Idiopathic bronchiectasis">Idiopathic bronchiectasis</a></span><ul><li><span class="matched_ds">Bronchiectasis with or without elevated sweat chloride 1</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37558605">Cystic fibrosis: Epidemiology, clinical manifestations, diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Diab Cáceres L,
|
||
Zamarrón de Lucas E</span><br />
|
||
<span class="medgenPMjournal">Med Clin (Barc)</span>
|
||
2023 Nov 10;161(9):389-396.
|
||
Epub 2023 Aug 7
|
||
doi: 10.1016/j.medcli.2023.06.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37558605" target="_blank">37558605</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34168062">Rheumatoid arthritis-interstitial lung disease: manifestations and current concepts in pathogenesis and management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kadura S,
|
||
Raghu G</span><br />
|
||
<span class="medgenPMjournal">Eur Respir Rev</span>
|
||
2021 Jun 30;30(160)
|
||
Epub 2021 Jun 23
|
||
doi: 10.1183/16000617.0011-2021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34168062" target="_blank">34168062</a><a href="/pmc/articles/PMC9489133" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215382">Bronchiectasis in children: diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chang AB,
|
||
Bush A,
|
||
Grimwood K</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Sep 8;392(10150):866-879.
|
||
doi: 10.1016/S0140-6736(18)31554-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30215382" target="_blank">30215382</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (765)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33542057">European Respiratory Society guidelines for the management of children and adolescents with bronchiectasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chang AB,
|
||
Fortescue R,
|
||
Grimwood K,
|
||
Alexopoulou E,
|
||
Bell L,
|
||
Boyd J,
|
||
Bush A,
|
||
Chalmers JD,
|
||
Hill AT,
|
||
Karadag B,
|
||
Midulla F,
|
||
McCallum GB,
|
||
Powell Z,
|
||
Snijders D,
|
||
Song WJ,
|
||
Tonia T,
|
||
Wilson C,
|
||
Zacharasiewicz A,
|
||
Kantar A</span><br />
|
||
<span class="medgenPMjournal">Eur Respir J</span>
|
||
2021 Aug;58(2)
|
||
Epub 2021 Aug 26
|
||
doi: 10.1183/13993003.02990-2020.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33542057" target="_blank">33542057</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30442957">Bronchiectasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chalmers JD,
|
||
Chang AB,
|
||
Chotirmall SH,
|
||
Dhar R,
|
||
McShane PJ</span><br />
|
||
<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
||
2018 Nov 15;4(1):45.
|
||
doi: 10.1038/s41572-018-0042-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30442957" target="_blank">30442957</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215383">Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Flume PA,
|
||
Chalmers JD,
|
||
Olivier KN</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Sep 8;392(10150):880-890.
|
||
doi: 10.1016/S0140-6736(18)31767-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30215383" target="_blank">30215383</a><a href="/pmc/articles/PMC6173801" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215382">Bronchiectasis in children: diagnosis and treatment.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chang AB,
|
||
Bush A,
|
||
Grimwood K</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2018 Sep 8;392(10150):866-879.
|
||
doi: 10.1016/S0140-6736(18)31554-X.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30215382" target="_blank">30215382</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28889110">European Respiratory Society guidelines for the management of adult bronchiectasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Polverino E,
|
||
Goeminne PC,
|
||
McDonnell MJ,
|
||
Aliberti S,
|
||
Marshall SE,
|
||
Loebinger MR,
|
||
Murris M,
|
||
Cantón R,
|
||
Torres A,
|
||
Dimakou K,
|
||
De Soyza A,
|
||
Hill AT,
|
||
Haworth CS,
|
||
Vendrell M,
|
||
Ringshausen FC,
|
||
Subotic D,
|
||
Wilson R,
|
||
Vilaró J,
|
||
Stallberg B,
|
||
Welte T,
|
||
Rohde G,
|
||
Blasi F,
|
||
Elborn S,
|
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Almagro M,
|
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Timothy A,
|
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Ruddy T,
|
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Tonia T,
|
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Rigau D,
|
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Chalmers JD</span><br />
|
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<span class="medgenPMjournal">Eur Respir J</span>
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2017 Sep;50(3)
|
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Epub 2017 Sep 9
|
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doi: 10.1183/13993003.00629-2017.
|
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<span class="bold">PMID: </span><a href="/pubmed/28889110" target="_blank">28889110</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4166)</a></div><h3 class="subhead">Diagnosis</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/37778637">Bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Barbosa M,
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Chalmers JD</span><br />
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<span class="medgenPMjournal">Presse Med</span>
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2023 Sep;52(3):104174.
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Epub 2023 Sep 30
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doi: 10.1016/j.lpm.2023.104174.
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<span class="bold">PMID: </span><a href="/pubmed/37778637" target="_blank">37778637</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/33526578">Bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gaffar S,
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Lee WW,
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Harrington JW</span><br />
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<span class="medgenPMjournal">Pediatr Rev</span>
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2021 Feb;42(2):103-105.
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doi: 10.1542/pir.2020-0110.
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<span class="bold">PMID: </span><a href="/pubmed/33526578" target="_blank">33526578</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/30442957">Bronchiectasis.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Chalmers JD,
|
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Chang AB,
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Chotirmall SH,
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Dhar R,
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McShane PJ</span><br />
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<span class="medgenPMjournal">Nat Rev Dis Primers</span>
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2018 Nov 15;4(1):45.
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doi: 10.1038/s41572-018-0042-3.
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<span class="bold">PMID: </span><a href="/pubmed/30442957" target="_blank">30442957</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/30215382">Bronchiectasis in children: diagnosis and treatment.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Chang AB,
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Bush A,
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Grimwood K</span><br />
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<span class="medgenPMjournal">Lancet</span>
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2018 Sep 8;392(10150):866-879.
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doi: 10.1016/S0140-6736(18)31554-X.
|
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<span class="bold">PMID: </span><a href="/pubmed/30215382" target="_blank">30215382</a></div>
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|
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<div class="nl"><a target="_blank" href="/pubmed/29489526">Bronchiectasis update.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">O'Donnell AE</span><br />
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<span class="medgenPMjournal">Curr Opin Infect Dis</span>
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2018 Apr;31(2):194-198.
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doi: 10.1097/QCO.0000000000000445.
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<span class="bold">PMID: </span><a href="/pubmed/29489526" target="_blank">29489526</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4744)</a></div><h3 class="subhead">Therapy</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38782469">Bronchiectasis management in adults: state of the art and future directions.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Choi H,
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McShane PJ,
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Aliberti S,
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Chalmers JD</span><br />
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<span class="medgenPMjournal">Eur Respir J</span>
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2024 Jun;63(6)
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Epub 2024 Jun 28
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doi: 10.1183/13993003.00518-2024.
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<span class="bold">PMID: </span><a href="/pubmed/38782469" target="_blank">38782469</a><a href="/pmc/articles/PMC11211698" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/37778637">Bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Barbosa M,
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Chalmers JD</span><br />
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<span class="medgenPMjournal">Presse Med</span>
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2023 Sep;52(3):104174.
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Epub 2023 Sep 30
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doi: 10.1016/j.lpm.2023.104174.
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<span class="bold">PMID: </span><a href="/pubmed/37778637" target="_blank">37778637</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/30442957">Bronchiectasis.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Chalmers JD,
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Chang AB,
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Chotirmall SH,
|
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Dhar R,
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McShane PJ</span><br />
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<span class="medgenPMjournal">Nat Rev Dis Primers</span>
|
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2018 Nov 15;4(1):45.
|
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doi: 10.1038/s41572-018-0042-3.
|
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<span class="bold">PMID: </span><a href="/pubmed/30442957" target="_blank">30442957</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30215382">Bronchiectasis in children: diagnosis and treatment.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Chang AB,
|
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Bush A,
|
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Grimwood K</span><br />
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<span class="medgenPMjournal">Lancet</span>
|
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2018 Sep 8;392(10150):866-879.
|
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doi: 10.1016/S0140-6736(18)31554-X.
|
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<span class="bold">PMID: </span><a href="/pubmed/30215382" target="_blank">30215382</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/28889110">European Respiratory Society guidelines for the management of adult bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Polverino E,
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Goeminne PC,
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McDonnell MJ,
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Aliberti S,
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Marshall SE,
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Loebinger MR,
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Murris M,
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Cantón R,
|
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Torres A,
|
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Dimakou K,
|
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De Soyza A,
|
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Hill AT,
|
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Haworth CS,
|
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Vendrell M,
|
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Ringshausen FC,
|
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Subotic D,
|
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Wilson R,
|
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Vilaró J,
|
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Stallberg B,
|
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Welte T,
|
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Rohde G,
|
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Blasi F,
|
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Elborn S,
|
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Almagro M,
|
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Timothy A,
|
||
Ruddy T,
|
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Tonia T,
|
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Rigau D,
|
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Chalmers JD</span><br />
|
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<span class="medgenPMjournal">Eur Respir J</span>
|
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2017 Sep;50(3)
|
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Epub 2017 Sep 9
|
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doi: 10.1183/13993003.00629-2017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28889110" target="_blank">28889110</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2753)</a></div><h3 class="subhead">Prognosis</h3>
|
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<div class="nl"><a target="_blank" href="/pubmed/39048130">Exacerbations of bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">De Angelis A,
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Johnson ED,
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Sutharsan S,
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Aliberti S</span><br />
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<span class="medgenPMjournal">Eur Respir Rev</span>
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2024 Jul;33(173)
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Epub 2024 Jul 24
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doi: 10.1183/16000617.0085-2024.
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<span class="bold">PMID: </span><a href="/pubmed/39048130" target="_blank">39048130</a><a href="/pmc/articles/PMC11267293" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/38960612">Biomarkers in bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Johnson E,
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Long MB,
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Chalmers JD</span><br />
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<span class="medgenPMjournal">Eur Respir Rev</span>
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2024 Jul;33(173)
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Epub 2024 Jul 3
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doi: 10.1183/16000617.0234-2023.
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<span class="bold">PMID: </span><a href="/pubmed/38960612" target="_blank">38960612</a><a href="/pmc/articles/PMC11220624" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/37778637">Bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Barbosa M,
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Chalmers JD</span><br />
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<span class="medgenPMjournal">Presse Med</span>
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2023 Sep;52(3):104174.
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Epub 2023 Sep 30
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doi: 10.1016/j.lpm.2023.104174.
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<span class="bold">PMID: </span><a href="/pubmed/37778637" target="_blank">37778637</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/29788932">Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chandrasekaran R,
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Mac Aogáin M,
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Chalmers JD,
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Elborn SJ,
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Chotirmall SH</span><br />
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<span class="medgenPMjournal">BMC Pulm Med</span>
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2018 May 22;18(1):83.
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doi: 10.1186/s12890-018-0638-0.
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<span class="bold">PMID: </span><a href="/pubmed/29788932" target="_blank">29788932</a><a href="/pmc/articles/PMC5964678" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28630359">Diagnosis and management of bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Smith MP</span><br />
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2017 Jun 19;189(24):E828-E835.
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<span class="bold">PMID: </span><a href="/pubmed/28630359" target="_blank">28630359</a><a href="/pmc/articles/PMC5478409" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2333)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38960612">Biomarkers in bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Johnson E,
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Long MB,
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Chalmers JD</span><br />
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<span class="medgenPMjournal">Eur Respir Rev</span>
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2024 Jul;33(173)
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Epub 2024 Jul 3
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doi: 10.1183/16000617.0234-2023.
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<span class="bold">PMID: </span><a href="/pubmed/38960612" target="_blank">38960612</a><a href="/pmc/articles/PMC11220624" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/35863486">A Double-Blind Randomized Placebo-Controlled Phase 3 Trial of Tobramycin Inhalation Solution in Adults With Bronchiectasis With Pseudomonas aeruginosa Infection.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Guan WJ,
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Xu JF,
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Luo H,
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Xu XX,
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Song YL,
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Ma WL,
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Liang ZA,
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Liu XD,
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Zhang GJ,
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Zhang XJ,
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Li RK,
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Zhu SY,
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Zhang YJ,
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Cai XJ,
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Wei LP,
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Tian DB,
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Zhao H,
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Chen PY,
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Qu JM,
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Zhong NS;
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TORNASOL Study Group</span><br />
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<span class="medgenPMjournal">Chest</span>
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2023 Jan;163(1):64-76.
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Epub 2022 Jul 19
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doi: 10.1016/j.chest.2022.07.007.
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<span class="bold">PMID: </span><a href="/pubmed/35863486" target="_blank">35863486</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/34437784">Triple Therapy for Cystic Fibrosis Phe508del-Gating and -Residual Function Genotypes.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Barry PJ,
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Mall MA,
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Álvarez A,
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Colombo C,
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de Winter-de Groot KM,
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Fajac I,
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McBennett KA,
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McKone EF,
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Ramsey BW,
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Sutharsan S,
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Taylor-Cousar JL,
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Tullis E,
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Ahluwalia N,
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Jun LS,
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Moskowitz SM,
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Prieto-Centurion V,
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Tian S,
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Waltz D,
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Xuan F,
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Zhang Y,
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Rowe SM,
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Polineni D;
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<span class="medgenPMjournal">N Engl J Med</span>
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2021 Aug 26;385(9):815-825.
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doi: 10.1056/NEJMoa2100665.
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<span class="bold">PMID: </span><a href="/pubmed/34437784" target="_blank">34437784</a><a href="/pmc/articles/PMC8982185" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/30215383">Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Flume PA,
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Chalmers JD,
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Olivier KN</span><br />
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<span class="medgenPMjournal">Lancet</span>
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2018 Sep 8;392(10150):880-890.
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doi: 10.1016/S0140-6736(18)31767-7.
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<span class="bold">PMID: </span><a href="/pubmed/30215383" target="_blank">30215383</a><a href="/pmc/articles/PMC6173801" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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<div class="nl"><a target="_blank" href="/pubmed/28889110">European Respiratory Society guidelines for the management of adult bronchiectasis.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Polverino E,
|
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Goeminne PC,
|
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McDonnell MJ,
|
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Aliberti S,
|
||
Marshall SE,
|
||
Loebinger MR,
|
||
Murris M,
|
||
Cantón R,
|
||
Torres A,
|
||
Dimakou K,
|
||
De Soyza A,
|
||
Hill AT,
|
||
Haworth CS,
|
||
Vendrell M,
|
||
Ringshausen FC,
|
||
Subotic D,
|
||
Wilson R,
|
||
Vilaró J,
|
||
Stallberg B,
|
||
Welte T,
|
||
Rohde G,
|
||
Blasi F,
|
||
Elborn S,
|
||
Almagro M,
|
||
Timothy A,
|
||
Ruddy T,
|
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Tonia T,
|
||
Rigau D,
|
||
Chalmers JD</span><br />
|
||
<span class="medgenPMjournal">Eur Respir J</span>
|
||
2017 Sep;50(3)
|
||
Epub 2017 Sep 9
|
||
doi: 10.1183/13993003.00629-2017.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28889110" target="_blank">28889110</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (2682)</a></div></div>
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||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
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<div class="nl"><a target="_blank" href="/pubmed/35235877">The effectiveness of the active cycle of breathing technique in patients with chronic respiratory diseases: A systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Zisi D,
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Chryssanthopoulos C,
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Nanas S,
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Philippou A</span><br />
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<span class="medgenPMjournal">Heart Lung</span>
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2022 May-Jun;53:89-98.
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Epub 2022 Feb 27
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doi: 10.1016/j.hrtlng.2022.02.006.
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<span class="bold">PMID: </span><a href="/pubmed/35235877" target="_blank">35235877</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33511633">Telerehabilitation for chronic respiratory disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Cox NS,
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Dal Corso S,
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Hansen H,
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McDonald CF,
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Hill CJ,
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Zanaboni P,
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Alison JA,
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O'Halloran P,
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Macdonald H,
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Holland AE</span><br />
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<span class="medgenPMjournal">Cochrane Database Syst Rev</span>
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2021 Jan 29;1(1):CD013040.
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doi: 10.1002/14651858.CD013040.pub2.
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<span class="bold">PMID: </span><a href="/pubmed/33511633" target="_blank">33511633</a><a href="/pmc/articles/PMC8095032" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/29478908">Bronchiectasis: new therapies and new perspectives.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chalmers JD,
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Chotirmall SH</span><br />
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<span class="medgenPMjournal">Lancet Respir Med</span>
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2018 Sep;6(9):715-726.
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Epub 2018 Feb 23
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doi: 10.1016/S2213-2600(18)30053-5.
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<span class="bold">PMID: </span><a href="/pubmed/29478908" target="_blank">29478908</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/28703105">Bronchial artery embolization in hemoptysis: a systematic review.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Panda A,
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Bhalla AS,
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Goyal A</span><br />
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<span class="medgenPMjournal">Diagn Interv Radiol</span>
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2017 Jul-Aug;23(4):307-317.
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doi: 10.5152/dir.2017.16454.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28703105" target="_blank">28703105</a><a href="/pmc/articles/PMC5508955" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25715965">Bronchiectasis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Magis-Escurra C,
|
||
Reijers MH</span><br />
|
||
<span class="medgenPMjournal">BMJ Clin Evid</span>
|
||
2015 Feb 25;2015
|
||
<span class="bold">PMID: </span><a href="/pubmed/25715965" target="_blank">25715965</a><a href="/pmc/articles/PMC4356176" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (197)</a></div></div>
|
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C2749757%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (77)</a></li>
|
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<li><a href="/gtr/tests?term=C2749757%5bDISCUI%5d&filter=method%3A2%5F12" target="_blank">Microsatellite instability testing (MSI) (1)</a></li>
|
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<li><a href="/gtr/tests?term=C2749757%5bDISCUI%5d&filter=method%3A2%5F18" target="_blank">Mutation scanning of select exons (1)</a></li>
|
||
<li><a href="/gtr/tests?term=C2749757%5bDISCUI%5d&filter=method%3A2%5F17" target="_blank">Mutation scanning of the entire coding region (1)</a></li>
|
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<li><a href="/gtr/tests?term=C2749757%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (86)</a></li>
|
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<li><a href="/gtr/tests?term=C2749757%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (8)</a></li>
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C2749757%5bDISCUI%5d" target="_blank">See all (98)</a></total></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(bronchiectasis%20with%20or%20without%20elevated%20sweat%20chloride%201)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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