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<meta name="keywords" content="C1853288, finding, increased rbc mass, increased red blood cell mass, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="The presence of an increased mass of red blood cells in the circulation." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=377869
|
||
ConceptID=C1853288
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Increased red blood cell mass</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>377869</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1853288</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Increased RBC mass</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0001898">HP:0001898</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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<div class="portlet mgSection" id="ID_100">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">The presence of an increased mass of red blood cells in the circulation. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Increased red blood cell mass</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/867443" ref="tree=MeSH" title="MedGen record for Phenotypic abnormality">Phenotypic abnormality</a></span><ul><li><span class="TLline"><a href="/medgen/163092" ref="tree=MeSH" title="MedGen record for Abnormality of blood and blood-forming tissues">Abnormality of blood and blood-forming tissues</a></span><ul><li><span class="TLline"><a href="/medgen/488883" ref="tree=MeSH" title="MedGen record for Abnormal erythrocyte morphology">Abnormal erythrocyte morphology</a></span><ul><li><span class="TLline"><a href="/medgen/18552" ref="tree=MeSH" title="MedGen record for Polycythemia">Polycythemia</a></span><ul><li><span class="matched_ds">Increased red blood cell mass</span></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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||
</div>
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||
|
||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_45996"><div><strong>Acquired polycythemia vera</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>45996</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0032463</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Polycythemia vera (PV), the most common form of primary polycythemia, is caused by somatic mutation in a single hematopoietic stem cell leading to clonal hematopoiesis. PV is a myeloproliferative disorder characterized predominantly by erythroid hyperplasia, but also by myeloid leukocytosis, thrombocytosis, and splenomegaly. Familial cases of PV are very rare and usually manifest in elderly patients (Cario, 2005). PV is distinct from the familial erythrocytoses (see, e.g., ECYT1, 133100), which are caused by inherited mutations resulting in hypersensitivity of erythroid progenitors to hormonal influences or increased levels of circulating hormones, namely erythropoietin (EPO; 133170) (Prchal, 2005).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/45996">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_332974"><div><strong>Chuvash polycythemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>332974</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1837915</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial erythrocytosis-2 (ECYT2) is an autosomal recessive disorder characterized by increased red blood cell mass, increased serum levels of erythropoietin (EPO; 133170), and normal oxygen affinity. Patients with ECYT2 carry a high risk for peripheral thrombosis and cerebrovascular events (Cario, 2005). Familial erythrocytosis-2 has features of both primary and secondary erythrocytosis. In addition to increased circulating levels of EPO, consistent with a secondary, extrinsic process, erythroid progenitors may be hypersensitive to EPO, consistent with a primary, intrinsic process (Prchal, 2005). For a general phenotypic description and a discussion of genetic heterogeneity of familial erythrocytosis, see ECYT1 (133100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/332974">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_377868"><div><strong>Erythrocytosis, familial, 3</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>377868</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C1853286</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial erythrocytosis is an inherited condition characterized by an increased number of red blood cells (erythrocytes). The primary function of these cells is to carry oxygen from the lungs to tissues and organs throughout the body. Signs and symptoms of familial erythrocytosis can include headaches, dizziness, nosebleeds, and shortness of breath. The excess red blood cells also increase the risk of developing abnormal blood clots that can block the flow of blood through arteries and veins. If these clots restrict blood flow to essential organs and tissues (particularly the heart, lungs, or brain), they can cause life-threatening complications such as a heart attack or stroke. However, many people with familial erythrocytosis experience only mild signs and symptoms or never have any problems related to their extra red blood cells.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/377868">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1641215"><div><strong>Primary familial polycythemia due to EPO receptor mutation</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1641215</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551637</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Primary familial and congenital erythrocytosis (PFCE), originally described as primary familial and congenital polycythemia, is characterized by isolated erythrocytosis in an individual with a normal to slightly enlarged spleen and absence of disorders causing secondary erythrocytosis. Clinical manifestations relate to the erythrocytosis and include rubor, and may or may not include hyperviscosity syndrome (headache, dizziness, altered mentation, visual disturbances, tinnitus, paresthesia, fatigue, lassitude, and weakness) and arterial and/or venous thromboembolic events. Although the majority of individuals with PFCE have absence of or only mild manifestations of hyperviscosity syndrome such as headache or dizziness, some affected individuals have severe and even fatal complications including arterial hypertension, coronary artery disease, myocardial infarction, intracerebral hemorrhage, and deep vein thrombosis (DVT). Phlebotomy-induced iron deficiency results in lassitude, impaired intellect, and impaired athletic performance, especially in children. Iron deficiency may also increase the risk of thromboses. Leukocyte count and differential are normal and platelet count tends to be low normal or slightly low due to hemodilution from increased red blood cells and increased whole blood volume.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1641215">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_45996" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Acquired polycythemia vera</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_332974" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Chuvash polycythemia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_377868" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Erythrocytosis, familial, 3</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1641215" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Primary familial polycythemia due to EPO receptor mutation</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39556352">Diagnosis and Treatment of Polycythemia Vera: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tremblay D,
|
||
Kremyanskaya M,
|
||
Mascarenhas J,
|
||
Hoffman R</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2025 Jan 14;333(2):153-160.
|
||
doi: 10.1001/jama.2024.20377.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39556352" target="_blank">39556352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34627656">Cardiovascular Health of Youth During Gender-Affirming Testosterone Treatment: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kean AC,
|
||
Saroufim R,
|
||
Meininger E,
|
||
Fuqua JS,
|
||
Fortenberry JD</span><br />
|
||
<span class="medgenPMjournal">J Adolesc Health</span>
|
||
2021 Dec;69(6):896-904.
|
||
Epub 2021 Oct 7
|
||
doi: 10.1016/j.jadohealth.2021.08.009.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34627656" target="_blank">34627656</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32873088">The advantages and risks of ruxolitinib for the treatment of polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Colafigli G,
|
||
Scalzulli E,
|
||
Pepe S,
|
||
Di Prima A,
|
||
Efficace F,
|
||
Martelli M,
|
||
Foà R,
|
||
Breccia M</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2020 Oct;13(10):1067-1072.
|
||
Epub 2020 Sep 11
|
||
doi: 10.1080/17474086.2020.1816819.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32873088" target="_blank">32873088</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22increased%20red%20blood%20cell%20mass%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (5)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39556352">Diagnosis and Treatment of Polycythemia Vera: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tremblay D,
|
||
Kremyanskaya M,
|
||
Mascarenhas J,
|
||
Hoffman R</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2025 Jan 14;333(2):153-160.
|
||
doi: 10.1001/jama.2024.20377.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39556352" target="_blank">39556352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32873088">The advantages and risks of ruxolitinib for the treatment of polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Colafigli G,
|
||
Scalzulli E,
|
||
Pepe S,
|
||
Di Prima A,
|
||
Efficace F,
|
||
Martelli M,
|
||
Foà R,
|
||
Breccia M</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2020 Oct;13(10):1067-1072.
|
||
Epub 2020 Sep 11
|
||
doi: 10.1080/17474086.2020.1816819.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32873088" target="_blank">32873088</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/22154053">Erythroid proliferations in myeloid neoplasms.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wang SA,
|
||
Hasserjian RP</span><br />
|
||
<span class="medgenPMjournal">Hum Pathol</span>
|
||
2012 Feb;43(2):153-64.
|
||
Epub 2011 Dec 9
|
||
doi: 10.1016/j.humpath.2011.08.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/22154053" target="_blank">22154053</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21496586">Polycythemia and chorea.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marvi MM,
|
||
Lew MF</span><br />
|
||
<span class="medgenPMjournal">Handb Clin Neurol</span>
|
||
2011;100:271-6.
|
||
doi: 10.1016/B978-0-444-52014-2.00019-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21496586" target="_blank">21496586</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15152961">Polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stuart BJ,
|
||
Viera AJ</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2004 May 1;69(9):2139-44.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15152961" target="_blank">15152961</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20red%20blood%20cell%20mass%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (13)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39556352">Diagnosis and Treatment of Polycythemia Vera: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tremblay D,
|
||
Kremyanskaya M,
|
||
Mascarenhas J,
|
||
Hoffman R</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2025 Jan 14;333(2):153-160.
|
||
doi: 10.1001/jama.2024.20377.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39556352" target="_blank">39556352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/33370224">Erythrocytosis: genes and pathways involved in disease development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gašperšič J,
|
||
Kristan A,
|
||
Kunej T,
|
||
Zupan IP,
|
||
Debeljak N</span><br />
|
||
<span class="medgenPMjournal">Blood Transfus</span>
|
||
2021 Nov;19(6):518-532.
|
||
Epub 2020 Dec 16
|
||
doi: 10.2450/2020.0197-20.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33370224" target="_blank">33370224</a><a href="/pmc/articles/PMC8580782" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32873088">The advantages and risks of ruxolitinib for the treatment of polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Colafigli G,
|
||
Scalzulli E,
|
||
Pepe S,
|
||
Di Prima A,
|
||
Efficace F,
|
||
Martelli M,
|
||
Foà R,
|
||
Breccia M</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2020 Oct;13(10):1067-1072.
|
||
Epub 2020 Sep 11
|
||
doi: 10.1080/17474086.2020.1816819.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32873088" target="_blank">32873088</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21496586">Polycythemia and chorea.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Marvi MM,
|
||
Lew MF</span><br />
|
||
<span class="medgenPMjournal">Handb Clin Neurol</span>
|
||
2011;100:271-6.
|
||
doi: 10.1016/B978-0-444-52014-2.00019-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21496586" target="_blank">21496586</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15152961">Polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Stuart BJ,
|
||
Viera AJ</span><br />
|
||
<span class="medgenPMjournal">Am Fam Physician</span>
|
||
2004 May 1;69(9):2139-44.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15152961" target="_blank">15152961</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20red%20blood%20cell%20mass%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (20)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39556352">Diagnosis and Treatment of Polycythemia Vera: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tremblay D,
|
||
Kremyanskaya M,
|
||
Mascarenhas J,
|
||
Hoffman R</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2025 Jan 14;333(2):153-160.
|
||
doi: 10.1001/jama.2024.20377.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39556352" target="_blank">39556352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34676782">Blood volume expansion, normovolemia, and clinical outcomes in chronic human heart failure: more is better.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Miller WL,
|
||
Strobeck JE,
|
||
Grill DE,
|
||
Mullan BP</span><br />
|
||
<span class="medgenPMjournal">Am J Physiol Heart Circ Physiol</span>
|
||
2021 Dec 1;321(6):H1074-H1082.
|
||
Epub 2021 Oct 22
|
||
doi: 10.1152/ajpheart.00336.2021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34676782" target="_blank">34676782</a><a href="/pmc/articles/PMC9095049" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32873088">The advantages and risks of ruxolitinib for the treatment of polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Colafigli G,
|
||
Scalzulli E,
|
||
Pepe S,
|
||
Di Prima A,
|
||
Efficace F,
|
||
Martelli M,
|
||
Foà R,
|
||
Breccia M</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2020 Oct;13(10):1067-1072.
|
||
Epub 2020 Sep 11
|
||
doi: 10.1080/17474086.2020.1816819.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32873088" target="_blank">32873088</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19421140">Kinase drug discovery approaches in chronic myeloproliferative disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kumar C,
|
||
Purandare AV,
|
||
Lee FY,
|
||
Lorenzi MV</span><br />
|
||
<span class="medgenPMjournal">Oncogene</span>
|
||
2009 Jun 18;28(24):2305-13.
|
||
Epub 2009 May 4
|
||
doi: 10.1038/onc.2009.107.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19421140" target="_blank">19421140</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11242597">Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Prchal JT</span><br />
|
||
<span class="medgenPMjournal">Semin Hematol</span>
|
||
2001 Jan;38(1 Suppl 2):10-20.
|
||
doi: 10.1016/s0037-1963(01)90135-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11242597" target="_blank">11242597</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20red%20blood%20cell%20mass%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/32873088">The advantages and risks of ruxolitinib for the treatment of polycythemia vera.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Colafigli G,
|
||
Scalzulli E,
|
||
Pepe S,
|
||
Di Prima A,
|
||
Efficace F,
|
||
Martelli M,
|
||
Foà R,
|
||
Breccia M</span><br />
|
||
<span class="medgenPMjournal">Expert Rev Hematol</span>
|
||
2020 Oct;13(10):1067-1072.
|
||
Epub 2020 Sep 11
|
||
doi: 10.1080/17474086.2020.1816819.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32873088" target="_blank">32873088</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25099339">'Ome' on the range: update on high-altitude acclimatization/adaptation and disease.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Luo Y,
|
||
Wang Y,
|
||
Lu H,
|
||
Gao Y</span><br />
|
||
<span class="medgenPMjournal">Mol Biosyst</span>
|
||
2014 Nov;10(11):2748-55.
|
||
doi: 10.1039/c4mb00119b.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25099339" target="_blank">25099339</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19421140">Kinase drug discovery approaches in chronic myeloproliferative disorders.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kumar C,
|
||
Purandare AV,
|
||
Lee FY,
|
||
Lorenzi MV</span><br />
|
||
<span class="medgenPMjournal">Oncogene</span>
|
||
2009 Jun 18;28(24):2305-13.
|
||
Epub 2009 May 4
|
||
doi: 10.1038/onc.2009.107.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19421140" target="_blank">19421140</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10069355">Diagnosing polycythemia vera: a paradigm shift.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Mayo Clin Proc</span>
|
||
1999 Feb;74(2):159-62.
|
||
doi: 10.4065/74.2.159.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10069355" target="_blank">10069355</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/8036133">Biological and radiological investigations in patients with an increased red blood cell mass: Which are needed? Which are useful? which are unnecessary?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Delannoy A</span><br />
|
||
<span class="medgenPMjournal">Nouv Rev Fr Hematol (1978)</span>
|
||
1994 Apr;36(2):159-63.
|
||
<span class="bold">PMID: </span><a href="/pubmed/8036133" target="_blank">8036133</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20red%20blood%20cell%20mass%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (8)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39556352">Diagnosis and Treatment of Polycythemia Vera: A Review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tremblay D,
|
||
Kremyanskaya M,
|
||
Mascarenhas J,
|
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Hoffman R</span><br />
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<span class="medgenPMjournal">JAMA</span>
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2025 Jan 14;333(2):153-160.
|
||
doi: 10.1001/jama.2024.20377.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39556352" target="_blank">39556352</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34676782">Blood volume expansion, normovolemia, and clinical outcomes in chronic human heart failure: more is better.</a></div>
|
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<div class="portlet_content ln"><span class="medgenPMauthor">Miller WL,
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Strobeck JE,
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Grill DE,
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Mullan BP</span><br />
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<span class="medgenPMjournal">Am J Physiol Heart Circ Physiol</span>
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2021 Dec 1;321(6):H1074-H1082.
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Epub 2021 Oct 22
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doi: 10.1152/ajpheart.00336.2021.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34676782" target="_blank">34676782</a><a href="/pmc/articles/PMC9095049" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
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|
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<div class="nl"><a target="_blank" href="/pubmed/25099339">'Ome' on the range: update on high-altitude acclimatization/adaptation and disease.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Luo Y,
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Wang Y,
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Lu H,
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2014 Nov;10(11):2748-55.
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doi: 10.1039/c4mb00119b.
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<span class="bold">PMID: </span><a href="/pubmed/25099339" target="_blank">25099339</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17033265">Polycythemia as the first manifestation of Cushing's disease.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Gursoy A,
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Dogruk Unal A,
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Ayturk S,
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Karakus S,
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Nur Izol A,
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2006 Sep;29(8):742-4.
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<span class="bold">PMID: </span><a href="/pubmed/17033265" target="_blank">17033265</a></div>
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|
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<div class="nl"><a target="_blank" href="/pubmed/8036133">Biological and radiological investigations in patients with an increased red blood cell mass: Which are needed? Which are useful? which are unnecessary?</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Delannoy A</span><br />
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<span class="bold">PMID: </span><a href="/pubmed/8036133" target="_blank">8036133</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Increased%20red%20blood%20cell%20mass%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6)</a></div></div>
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