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<meta name="keywords" content="C1833921, familial medullary thyroid carcinoma, familial mtc, familial thyroid gland medullary carcinoma, fmtc, hereditary medullary thyroid gland carcinoma, hereditary thyroid gland medullary carcinoma, hereditary thyroid medullary carcinoma, medullary thyroid cancer, familial, mtc, mtc, familial, mtc1, neoplastic process, ntrk1-related familial medullary thyroid carcinoma, ret, thyroid cancer, familial medullary, thyroid carcinoma, familial medullary, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Multiple endocrine neoplasia type 2 (MEN2) includes the following phenotypes: MEN2A, familial medullary thyroid carcinoma (FMTC, which may be a variant of MEN2A), and MEN2B. All three phenotypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN2A and MEN2B involve an increased risk for pheochromocytoma; MEN2A involves an increased risk for parathyroid adenoma or hyperplasia. Additional features of MEN2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and a marfanoid habitus. MTC typically occurs in early childhood in MEN2B, early adulthood in MEN2A, and middle age in FMTC." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=322311
|
||
ConceptID=C1833921
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Familial medullary thyroid carcinoma<span class="h1sub">(MTC)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>322311</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1833921</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>MTC; MTC, familial; NTRK1-Related Familial Medullary Thyroid Carcinoma; Thyroid cancer, familial medullary</td></tr>
|
||
<tr><td>Modes of inheritance:</td>
|
||
<td>
|
||
<div class="divPopper rprt" id="moi_141047"><div><strong>Autosomal dominant inheritance</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>141047</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0443147</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Intellectual Product</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Source: Orphanet</div>
|
||
<div class="spaceAbove">A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.</div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#moi_141047" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant inheritance</a><span> (Orphanet)</span></div></td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="RET - ID: 5979 - NCBI Gene" href="/gene/5979" class="medgenPMinfo">RET</a> (10q11.21)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0007958" target="_blank">MONDO:0007958</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/155240" target="_blank">155240</a></td></tr>
|
||
<tr><td>Orphanet:</td>
|
||
<td><a target="_blank" title="Orphanet: The portal for rare diseases and orphan drugs" href="http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=99361">ORPHA99361</a></td></tr></tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_101">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Disease_characteristics">Disease characteristics</h1><a sid="101" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="excerpt">Excerpted from the <i>GeneReview: </i><a href="/books/NBK1257" target="_blank">Multiple Endocrine Neoplasia Type 2</a></div><div>Multiple endocrine neoplasia type 2 (MEN2) includes the following phenotypes: MEN2A, familial medullary thyroid carcinoma (FMTC, which may be a variant of MEN2A), and MEN2B. All three phenotypes involve high risk for development of medullary carcinoma of the thyroid (MTC); MEN2A and MEN2B involve an increased risk for pheochromocytoma; MEN2A involves an increased risk for parathyroid adenoma or hyperplasia. Additional features of MEN2B include mucosal neuromas of the lips and tongue, distinctive facies with enlarged lips, ganglioneuromatosis of the gastrointestinal tract, and a marfanoid habitus. MTC typically occurs in early childhood in MEN2B, early adulthood in MEN2A, and middle age in FMTC. [from <a title="GeneReviews" href="https://www.ncbi.nlm.nih.gov/books/NBK1116" class="defSource" target="_blank">GeneReviews</a>]</div><div class="spaceAbove"><strong>Full text of <i>GeneReview</i> (by section):</strong><br /><a class="medgenPMinfo" href="/books/NBK1257#men2.Summary" target="NBK1257">Summary</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.GeneReview_Scope" target="NBK1257">GeneReview Scope</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Diagnosis" target="NBK1257">Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Clinical_Characteristics" target="NBK1257">Clinical Characteristics</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Genetically_Related_Allelic_Disorde" target="NBK1257">Genetically Related (Allelic) Disorders</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Differential_Diagnosis" target="NBK1257">Differential Diagnosis</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Management" target="NBK1257">Management</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Genetic_Counseling" target="NBK1257">Genetic Counseling</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Resources" target="NBK1257">Resources</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Molecular_Genetics" target="NBK1257">Molecular Genetics</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.Chapter_Notes" target="NBK1257">Chapter Notes</a> | <a class="medgenPMinfo" href="/books/NBK1257#men2.References" target="NBK1257">References</a></div><div class="spaceAbove"><strong>Authors:</strong><br />
|
||
Charis Eng | Gilman Plitt <a href="/books/NBK1257" target="NBK1257" title="NCBI Bookshelf: Multiple Endocrine Neoplasia Type 2">view full author information</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_117">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Additional_descriptions">Additional descriptions</h1><a sid="117" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><div class="mgSection"><strong>From OMIM</strong><br />Medullary thyroid carcinoma (MTC) is a malignant tumor of the calcitonin (114130)-secreting parafollicular C cells of the thyroid, and occurs sporadically or as a component of the multiple endocrine neoplasia (MEN) type 2 (see 171400)/familial medullary thyroid carcinoma (FMTC) syndromes (summary by Abu-Amero et al., 2006). Thyroid cancer derived from follicular epithelial cells is referred to as nonmedullary thyroid cancer and comprises several subtypes; see 188550. <a target="_blank" href="http://www.omim.org/entry/155240">http://www.omim.org/entry/155240</a></div><div class="mgSection"><strong>From MedlinePlus Genetics</strong><br />Multiple endocrine neoplasia type 4 appears to have signs and symptoms similar to those of type 1, although it is caused by mutations in a different gene. Hyperparathyroidism is the most common feature, followed by tumors of the pituitary gland, additional endocrine glands, and other organs.<br /><br />The most common sign of multiple endocrine neoplasia type 2 is a form of thyroid cancer called medullary thyroid carcinoma. Some people with this disorder also develop a pheochromocytoma, which is an adrenal gland tumor that can cause dangerously high blood pressure. Multiple endocrine neoplasia type 2 is divided into three subtypes: type 2A, type 2B (formerly called type 3), and familial medullary thyroid carcinoma (FMTC). These subtypes differ in their characteristic signs and symptoms and risk of specific tumors; for example, hyperparathyroidism occurs only in type 2A, and medullary thyroid carcinoma is the only feature of FMTC. The signs and symptoms of multiple endocrine neoplasia type 2 are relatively consistent within any one family.<br /><br />Many different types of tumors are associated with multiple endocrine neoplasia. Type 1 frequently involves tumors of the parathyroid glands, the pituitary gland, and the pancreas. Tumors in these glands can lead to the overproduction of hormones. The most common sign of multiple endocrine neoplasia type 1 is overactivity of the parathyroid glands (hyperparathyroidism). Hyperparathyroidism disrupts the normal balance of calcium in the blood, which can lead to kidney stones, thinning of bones, nausea and vomiting, high blood pressure (hypertension), weakness, and fatigue.<br /><br />The major forms of multiple endocrine neoplasia are called type 1, type 2, and type 4. These types are distinguished by the genes involved, the types of hormones made, and the characteristic signs and symptoms.<br /><br />Multiple endocrine neoplasia is a group of disorders that affect the body's network of hormone-producing glands called the endocrine system. Hormones are chemical messengers that travel through the bloodstream and regulate the function of cells and tissues throughout the body. Multiple endocrine neoplasia typically involves tumors (neoplasia) in at least two endocrine glands; tumors can also develop in other organs and tissues. These growths can be noncancerous (benign) or cancerous (malignant). If the tumors become cancerous, the condition can be life-threatening. <a target="_blank" href="https://medlineplus.gov/genetics/condition/multiple-endocrine-neoplasia">https://medlineplus.gov/genetics/condition/multiple-endocrine-neoplasia</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_102">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_features">Clinical features</h1><a sid="102" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat"><strong>From HPO</strong><br />
|
||
<div class="divPopper rprt" id="clin_66772"><div><strong>Medullary thyroid carcinoma</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>66772</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0238462</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The presence of a medullary carcinoma of the thyroid gland.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/66772">Feature record</a> | <a href="/medgen?term=%22Medullary%20thyroid%20carcinoma%22%5BClinical%20Features%5D%20OR%2066772%5Buid%5D">Search on this feature</a></div></div><div class="TreeLite"><ul><li><span class="TLline">Neoplasm</span><ul><li class="TLline">
|
||
<span class="TLline"><a title="click for more information" class="jig-ncbipopper" href="#clin_66772" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Medullary thyroid carcinoma</a></span></li></ul></li></ul></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_118">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li><li><a href="#tabORDO">Orphanet</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C4048306[DISCUI]&test_type=Clinical" ref="ncbi_uid=887211">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1257/" ref="ncbi_uid=887211">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=887211" ref="ncbi_uid=887211">V</a></span></span><span class="TLline"><a href="/medgen/887211" ref="tree=GTR&ncbi_uid=887211&link_uid=887211" title="View MedGen record for 'Multiple endocrine neoplasia, type 2'">Multiple endocrine neoplasia, type 2</a></span><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1833921[DISCUI]&test_type=Clinical" ref="ncbi_uid=322311">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=322311" target="_blank" href="/omim/155240">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1257/" ref="ncbi_uid=322311">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=322311" ref="ncbi_uid=322311">V</a></span></span><span class="TLline">Familial medullary thyroid carcinoma</span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0025268[DISCUI]&test_type=Clinical" ref="ncbi_uid=9958">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=9958" target="_blank" href="/omim/164761">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1257/" ref="ncbi_uid=9958">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9958" ref="ncbi_uid=9958">V</a></span></span><span class="TLline"><a href="/medgen/9958" ref="tree=GTR&ncbi_uid=9958&link_uid=9958" title="View MedGen record for 'Multiple endocrine neoplasia type 2A'">Multiple endocrine neoplasia type 2A</a></span></li><li class="TLclosed"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C0025269[DISCUI]&test_type=Clinical" ref="ncbi_uid=9959">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet Ocolor" title="OMIM"><a ref="ncbi_uid=9959" target="_blank" href="/omim/162300">O</a></span><span class="chiclet Gcolor" title="GeneReviews"><a target="_blank" href="/books/NBK1257/" ref="ncbi_uid=9959">G</a></span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=9959" ref="ncbi_uid=9959">V</a></span></span><span class="TLline"><a href="/medgen/9959" ref="tree=GTR&ncbi_uid=9959&link_uid=9959" title="View MedGen record for 'Multiple endocrine neoplasia type 2B'">Multiple endocrine neoplasia type 2B</a></span></li></ul></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/21047" ref="tree=MeSH" title="MedGen record for Pathological Conditions, Signs and Symptoms">Pathological Conditions, Signs and Symptoms</a></span><ul><li><span class="TLline"><a href="/medgen/18325" ref="tree=MeSH" title="MedGen record for Pathological process">Pathological process</a></span><ul><li><span class="TLline"><a href="/medgen/4347" ref="tree=MeSH" title="MedGen record for Disease">Disease</a></span><ul><li><span class="TLline"><a href="/medgen/10294" ref="tree=MeSH" title="MedGen record for Neoplasm">Neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/14297" ref="tree=MeSH" title="MedGen record for Malignant neoplastic disease">Malignant neoplastic disease</a></span><ul><li><span class="TLline"><a href="/medgen/232504" ref="tree=MeSH" title="MedGen record for Hereditary cancer">Hereditary cancer</a></span><ul><li><span class="matched_ds">Familial medullary thyroid carcinoma</span><ul><li><span class="TLline"><a href="/medgen/1756444" ref="tree=MeSH" title="MedGen record for Recurrent Hereditary Thyroid Gland Medullary Carcinoma">Recurrent Hereditary Thyroid Gland Medullary Carcinoma</a></span></li><li><span class="TLline"><a href="/medgen/1764319" ref="tree=MeSH" title="MedGen record for Unresectable Hereditary Thyroid Gland Medullary Carcinoma">Unresectable Hereditary Thyroid Gland Medullary Carcinoma</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div><div id="tabORDO">Follow <a target="_blank" href="http://www.orpha.net/consor/cgi-bin/Disease_Classif.php?lng=EN&data_id=156&PatId=14205&search=Disease_Classif_Simple&new=1" class="ital bold">this link</a> to review classifications for <span class="ital">Familial medullary thyroid carcinoma</span> in Orphanet.</div></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26974132">Medullary thyroid carcinoma: a review on ethical considerations in treatment of children.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nozhat Z,
|
||
Hedayati M</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Endocrinol Metab</span>
|
||
2016 Jun 1;29(6):633-9.
|
||
doi: 10.1515/jpem-2015-0309.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26974132" target="_blank">26974132</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26839093">Management of hereditary medullary thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Pappa T,
|
||
Alevizaki M</span><br />
|
||
<span class="medgenPMjournal">Endocrine</span>
|
||
2016 Jul;53(1):7-17.
|
||
Epub 2016 Feb 2
|
||
doi: 10.1007/s12020-016-0873-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26839093" target="_blank">26839093</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26494387">Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Frank-Raue K,
|
||
Raue F</span><br />
|
||
<span class="medgenPMjournal">Recent Results Cancer Res</span>
|
||
2015;204:139-56.
|
||
doi: 10.1007/978-3-319-22542-5_6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/26494387" target="_blank">26494387</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22familial%20medullary%20thyroid%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (25)</a></div><h3 class="subhead">Curated<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpCurated"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/21863057">Clinical utility gene card for: multiple endocrine neoplasia type 2.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Raue F,
|
||
Rondot S,
|
||
Schulze E,
|
||
Szpak-Ulczok S,
|
||
Jarzab B,
|
||
Frank-Raue K</span><br />
|
||
<span class="medgenPMjournal">Eur J Hum Genet</span>
|
||
2012 Jan;20(1)
|
||
Epub 2011 Aug 24
|
||
doi: 10.1038/ejhg.2011.142.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21863057" target="_blank">21863057</a><a href="/pmc/articles/PMC3234510" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div><h3 class="nl vspace"><a href="https://www.nice.org.uk/guidance/ng230" target="_blank">UK NICE Guideline NG230, Thyroid cancer: assessment and management</a></h3>
|
||
</div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_114">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Suggested_Reading">Suggested Reading</h1><a sid="114" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389271">Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389271" target="_blank">26389271</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/26389258">Cancer Genetics Risk Assessment and Counseling (PDQ®): Health Professional Version.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">PDQ Cancer Genetics Editorial Board</span><br />
|
||
|
||
2002
|
||
<span class="bold">PMID: </span><a href="/pubmed/26389258" target="_blank">26389258</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=" title="PubMed search"></a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33249201">Molecular targets of tyrosine kinase inhibitors in thyroid cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fallahi P,
|
||
Ferrari SM,
|
||
Galdiero MR,
|
||
Varricchi G,
|
||
Elia G,
|
||
Ragusa F,
|
||
Paparo SR,
|
||
Benvenga S,
|
||
Antonelli A</span><br />
|
||
<span class="medgenPMjournal">Semin Cancer Biol</span>
|
||
2022 Feb;79:180-196.
|
||
Epub 2020 Nov 26
|
||
doi: 10.1016/j.semcancer.2020.11.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33249201" target="_blank">33249201</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31043326">Long-term outcome after DNA-based prophylactic neck surgery in children at risk of hereditary medullary thyroid cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Machens A,
|
||
Dralle H</span><br />
|
||
<span class="medgenPMjournal">Best Pract Res Clin Endocrinol Metab</span>
|
||
2019 Aug;33(4):101274.
|
||
Epub 2019 Apr 17
|
||
doi: 10.1016/j.beem.2019.04.008.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31043326" target="_blank">31043326</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29239041">Hereditary and familial thyroid tumours.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guilmette J,
|
||
Nosé V</span><br />
|
||
<span class="medgenPMjournal">Histopathology</span>
|
||
2018 Jan;72(1):70-81.
|
||
doi: 10.1111/his.13373.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29239041" target="_blank">29239041</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23512389">Medullary thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Griebeler ML,
|
||
Gharib H,
|
||
Thompson GB</span><br />
|
||
<span class="medgenPMjournal">Endocr Pract</span>
|
||
2013 Jul-Aug;19(4):703-11.
|
||
doi: 10.4158/EP12430.RA.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23512389" target="_blank">23512389</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18434223">Inherited endocrinopathies: an update.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Lewis CE,
|
||
Yeh MW</span><br />
|
||
<span class="medgenPMjournal">Mol Genet Metab</span>
|
||
2008 Jul;94(3):271-82.
|
||
Epub 2008 Apr 22
|
||
doi: 10.1016/j.ymgme.2008.03.006.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18434223" target="_blank">18434223</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20medullary%20thyroid%20carcinoma%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (144)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/33249201">Molecular targets of tyrosine kinase inhibitors in thyroid cancer.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Fallahi P,
|
||
Ferrari SM,
|
||
Galdiero MR,
|
||
Varricchi G,
|
||
Elia G,
|
||
Ragusa F,
|
||
Paparo SR,
|
||
Benvenga S,
|
||
Antonelli A</span><br />
|
||
<span class="medgenPMjournal">Semin Cancer Biol</span>
|
||
2022 Feb;79:180-196.
|
||
Epub 2020 Nov 26
|
||
doi: 10.1016/j.semcancer.2020.11.013.
|
||
<span class="bold">PMID: </span><a href="/pubmed/33249201" target="_blank">33249201</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29239041">Hereditary and familial thyroid tumours.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Guilmette J,
|
||
Nosé V</span><br />
|
||
<span class="medgenPMjournal">Histopathology</span>
|
||
2018 Jan;72(1):70-81.
|
||
doi: 10.1111/his.13373.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29239041" target="_blank">29239041</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/25810047">Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wells SA Jr,
|
||
Asa SL,
|
||
Dralle H,
|
||
Elisei R,
|
||
Evans DB,
|
||
Gagel RF,
|
||
Lee N,
|
||
Machens A,
|
||
Moley JF,
|
||
Pacini F,
|
||
Raue F,
|
||
Frank-Raue K,
|
||
Robinson B,
|
||
Rosenthal MS,
|
||
Santoro M,
|
||
Schlumberger M,
|
||
Shah M,
|
||
Waguespack SG;
|
||
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<div class="nl"><a target="_blank" href="/pubmed/33249201">Molecular targets of tyrosine kinase inhibitors in thyroid cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fallahi P,
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Ferrari SM,
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Varricchi G,
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Elia G,
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<div class="nl"><a target="_blank" href="/pubmed/31043326">Long-term outcome after DNA-based prophylactic neck surgery in children at risk of hereditary medullary thyroid cancer.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/16840909">C-cell hyperplasia.</a></div>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20medullary%20thyroid%20carcinoma%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (28)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/38441533">Pediatric Medullary Thyroid Carcinoma: Clinical Presentations and Long-Term Outcomes in 144 Patients Over 6 Decades.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33249201">Molecular targets of tyrosine kinase inhibitors in thyroid cancer.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Fallahi P,
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Ferrari SM,
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Galdiero MR,
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Varricchi G,
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Elia G,
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Ragusa F,
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2022 Feb;79:180-196.
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doi: 10.1016/j.semcancer.2020.11.013.
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<span class="bold">PMID: </span><a href="/pubmed/33249201" target="_blank">33249201</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/33492588">Genomics and Epigenomics of Medullary Thyroid Carcinoma: From Sporadic Disease to Familial Manifestations.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26839093">Management of hereditary medullary thyroid carcinoma.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Pappa T,
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Gharib H,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20medullary%20thyroid%20carcinoma%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (100)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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<div class="nl"><a target="_blank" href="/pubmed/26494387">Hereditary Medullary Thyroid Cancer Genotype-Phenotype Correlation.</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/25972318">Molecular pathology of hereditary and sporadic medullary thyroid carcinomas.</a></div>
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Romei C,
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Familial%20medullary%20thyroid%20carcinoma%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (75)</a></div></div>
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||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
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<div class="supplemental col three_col last">
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<h2 class="offscreen_noflow">Supplemental Content</h2>
|
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<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1833921%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (58)</a></li>
|
||
<li><a href="/gtr/tests?term=C1833921%5bDISCUI%5d&filter=method%3A2%5F30" target="_blank">RNA analysis (2)</a></li>
|
||
<li><a href="/gtr/tests?term=C1833921%5bDISCUI%5d&filter=method%3A2%5F9" target="_blank">Sequence analysis of select exons (6)</a></li>
|
||
<li><a href="/gtr/tests?term=C1833921%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (73)</a></li>
|
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<li><a href="/gtr/tests?term=C1833921%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (7)</a></li>
|
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<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1833921%5bDISCUI%5d" target="_blank">See all (86)</a></total></li>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22familial%20medullary%20thyroid%20carcinoma%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li><li><a target="_blank" href="/books/?term=((%22clinical%20guidelines%22%5BResource%20Type%5D)%20OR%20%22practice%20guideline%22%5BPublication%20Type%5D)%20AND%20(%22Familial%20medullary%20thyroid%20carcinoma%22)">Bookshelf</a><div class="help-popup">See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul><h3 class="subhead">Curated</h3><ul class="a_poppers"><li><a target="_blank" href="https://www.nice.org.uk/guidance/ng230">NICE, 2022</a><div>UK NICE Guideline NG230, Thyroid cancer: assessment and management</div></li><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov//21863057/">EuroGenetest, 2011</a><div>Clinical utility gene card for: multiple endocrine neoplasia type 2.</div></li></ul></div>
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<div class="portlet mgSection" id="ID_115">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=164761" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=5979[geneid]" target="_blank">View RET variations in ClinVar</a></li><li><a href="/nuccore/171184431" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=155240" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/thyroid_carcinoma_familial_medullary" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Familial%20medullary%20thyroid%20carcinoma" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/multiple-endocrine-neoplasia" target="_blank">MedlinePlusGenetics (GHR)</a></li><li><a href="https://rarediseases.info.nih.gov/diseases/16901/disease" target="_blank">NCATS Office of Rare Diseases Research (GARD)</a></li></ul></div>
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