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<meta name="keywords" content="C1832392, ctla4, ctla4 type 1 diabetes mellitus, diabetes mellitus, insulin-dependent, 12, diabetes mellitus, insulin-dependent, type 12, disease or syndrome, iddm12, insulin-dependent diabetes mellitus 12, t1d12, type 1 diabetes mellitus 12, type 1 diabetes mellitus caused by mutation in ctla4, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="Uncontrolled type 1 diabetes can lead to a life-threatening complication called diabetic ketoacidosis. Without insulin, cells cannot take in glucose. A lack of glucose in cells prompts the liver to try to compensate by releasing more glucose into the blood, and blood glucose can become extremely high. The cells, unable to use the glucose in the blood for energy, respond by using fats instead. Breaking down fats to obtain energy produces waste products called ketones, which can build up to toxic levels in people with type 1 diabetes, resulting in diabetic ketoacidosis. Affected individuals may begin breathing rapidly; develop a fruity odor in the breath; and experience nausea, vomiting, facial flushing, stomach pain, and dryness of the mouth (xerostomia). In severe cases, diabetic ketoacidosis can lead to coma and death.\n\nOver many years, the chronic high blood glucose associated with diabetes may cause damage to blood vessels and nerves, leading to complications affecting many organs and tissues. The retina, which is the light-sensitive tissue at the back of the eye, can be damaged (diabetic retinopathy), leading to vision loss and eventual blindness. Kidney damage (diabetic nephropathy) may also occur and can lead to kidney failure and end-stage renal disease (ESRD). Pain, tingling, and loss of normal sensation (diabetic neuropathy) often occur, especially in the feet. Impaired circulation and absence of the normal sensations that prompt reaction to injury can result in permanent damage to the feet; in severe cases, the damage can lead to amputation. People with type 1 diabetes are also at increased risk of heart attacks, strokes, and problems with urinary and sexual function.\n\nType 1 diabetes can occur at any age, from early childhood to late adulthood. The first signs and symptoms of the disorder are caused by high blood glucose and may include frequent urination (polyuria), excessive thirst (polydipsia), fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. These symptoms may recur during the course of the disorder if blood glucose is not well controlled by insulin replacement therapy. Improper control can also cause blood glucose levels to become too low (hypoglycemia). This may occur when the body's needs change, such as during exercise or if eating is delayed. Hypoglycemia can cause headache, dizziness, hunger, shaking, sweating, weakness, and agitation.\n\nType 1 diabetes is a disorder characterized by abnormally high levels of blood glucose, also called blood sugar. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of glucose in the blood." /><meta name="robots" content="index,nofollow,noarchive" />
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||
<!--
|
||
UID=318618
|
||
ConceptID=C1832392
|
||
-->
|
||
<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Type 1 diabetes mellitus 12<span class="h1sub">(T1D12)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>318618</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1832392</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Diabetes mellitus, insulin-dependent, 12; T1D12</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td><a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#target-gene-loc">Gene (location):<img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a><div class="display-none" id="target-gene-loc">
|
||
Gene(s) directly associated with<br />
|
||
this condition or phenotype.</div></td>
|
||
<td><a target="_blank" title="CTLA4 - ID: 1493 - NCBI Gene" href="/gene/1493" class="medgenPMinfo">CTLA4</a> (2q33.2)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>Monarch Initiative:</td>
|
||
<td><a href="https://monarchinitiative.org/disease/MONDO:0011068" target="_blank">MONDO:0011068</a></td></tr>
|
||
<tr><td>OMIM<span class="superscript">®</span>:</td>
|
||
<td><a href="https://omim.org/entry/601388" target="_blank">601388</a></td></tr>
|
||
</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
|
||
<div class="portlet mgSection" id="ID_100">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Definition">Definition</h1><a sid="100" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">Uncontrolled type 1 diabetes can lead to a life-threatening complication called diabetic ketoacidosis. Without insulin, cells cannot take in glucose. A lack of glucose in cells prompts the liver to try to compensate by releasing more glucose into the blood, and blood glucose can become extremely high. The cells, unable to use the glucose in the blood for energy, respond by using fats instead. Breaking down fats to obtain energy produces waste products called ketones, which can build up to toxic levels in people with type 1 diabetes, resulting in diabetic ketoacidosis. Affected individuals may begin breathing rapidly; develop a fruity odor in the breath; and experience nausea, vomiting, facial flushing, stomach pain, and dryness of the mouth (xerostomia). In severe cases, diabetic ketoacidosis can lead to coma and death.<br /><br />Over many years, the chronic high blood glucose associated with diabetes may cause damage to blood vessels and nerves, leading to complications affecting many organs and tissues. The retina, which is the light-sensitive tissue at the back of the eye, can be damaged (diabetic retinopathy), leading to vision loss and eventual blindness. Kidney damage (diabetic nephropathy) may also occur and can lead to kidney failure and end-stage renal disease (ESRD). Pain, tingling, and loss of normal sensation (diabetic neuropathy) often occur, especially in the feet. Impaired circulation and absence of the normal sensations that prompt reaction to injury can result in permanent damage to the feet; in severe cases, the damage can lead to amputation. People with type 1 diabetes are also at increased risk of heart attacks, strokes, and problems with urinary and sexual function.<br /><br />Type 1 diabetes can occur at any age, from early childhood to late adulthood. The first signs and symptoms of the disorder are caused by high blood glucose and may include frequent urination (polyuria), excessive thirst (polydipsia), fatigue, blurred vision, tingling or loss of feeling in the hands and feet, and weight loss. These symptoms may recur during the course of the disorder if blood glucose is not well controlled by insulin replacement therapy. Improper control can also cause blood glucose levels to become too low (hypoglycemia). This may occur when the body's needs change, such as during exercise or if eating is delayed. Hypoglycemia can cause headache, dizziness, hunger, shaking, sweating, weakness, and agitation.<br /><br />Type 1 diabetes is a disorder characterized by abnormally high levels of blood glucose, also called blood sugar. In this form of diabetes, specialized cells in the pancreas called beta cells stop producing insulin. Insulin controls how much glucose (a type of sugar) is passed from the blood into cells for conversion to energy. Lack of insulin results in the inability to use glucose for energy or to control the amount of glucose in the blood. [from <a title="MedlinePlus Genetics" href="https://medlineplus.gov/genetics/" class="defSource" target="_blank">MedlinePlus Genetics</a>]</div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36493795">Continuous glucose monitoring and metrics for clinical trials: an international consensus statement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Battelino T,
|
||
Alexander CM,
|
||
Amiel SA,
|
||
Arreaza-Rubin G,
|
||
Beck RW,
|
||
Bergenstal RM,
|
||
Buckingham BA,
|
||
Carroll J,
|
||
Ceriello A,
|
||
Chow E,
|
||
Choudhary P,
|
||
Close K,
|
||
Danne T,
|
||
Dutta S,
|
||
Gabbay R,
|
||
Garg S,
|
||
Heverly J,
|
||
Hirsch IB,
|
||
Kader T,
|
||
Kenney J,
|
||
Kovatchev B,
|
||
Laffel L,
|
||
Maahs D,
|
||
Mathieu C,
|
||
Mauricio D,
|
||
Nimri R,
|
||
Nishimura R,
|
||
Scharf M,
|
||
Del Prato S,
|
||
Renard E,
|
||
Rosenstock J,
|
||
Saboo B,
|
||
Ueki K,
|
||
Umpierrez GE,
|
||
Weinzimer SA,
|
||
Phillip M</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2023 Jan;11(1):42-57.
|
||
Epub 2022 Dec 6
|
||
doi: 10.1016/S2213-8587(22)00319-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36493795" target="_blank">36493795</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32568666">Psychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Winkley K,
|
||
Upsher R,
|
||
Stahl D,
|
||
Pollard D,
|
||
Kasera A,
|
||
Brennan A,
|
||
Heller S,
|
||
Ismail K</span><br />
|
||
<span class="medgenPMjournal">Health Technol Assess</span>
|
||
2020 Jun;24(28):1-232.
|
||
doi: 10.3310/hta24280.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32568666" target="_blank">32568666</a><a href="/pmc/articles/PMC7336224" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32142510">Dietary fibre and whole grains in diabetes management: Systematic review and meta-analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reynolds AN,
|
||
Akerman AP,
|
||
Mann J</span><br />
|
||
<span class="medgenPMjournal">PLoS Med</span>
|
||
2020 Mar;17(3):e1003053.
|
||
Epub 2020 Mar 6
|
||
doi: 10.1371/journal.pmed.1003053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32142510" target="_blank">32142510</a><a href="/pmc/articles/PMC7059907" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(type%201%20diabetes%20mellitus%2012)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (746)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39207742">Highs and Lows.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Durkin C</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2024 Sep 24;332(12):965-966.
|
||
doi: 10.1001/jama.2024.13675.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39207742" target="_blank">39207742</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38597269">Association Between Type 1 Diabetes Mellitus and Eating Disorders: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dean YE,
|
||
Motawea KR,
|
||
Aslam M,
|
||
Pintado JJL,
|
||
Popoola-Samuel HAO,
|
||
Salam M,
|
||
Dundi POR,
|
||
Donaldy W,
|
||
Aledani EM,
|
||
Alqiqie Z,
|
||
Sultana N,
|
||
Mohamed ARH,
|
||
Elalem A,
|
||
Syeda STH,
|
||
Mohamed MS,
|
||
Assal MW,
|
||
Attia NM,
|
||
Hagar H,
|
||
Abdelaziz HA,
|
||
Subedi A,
|
||
Elbahaie A,
|
||
Hazimeh Y,
|
||
Aiash H</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Diabetes Metab</span>
|
||
2024 May;7(3):e473.
|
||
doi: 10.1002/edm2.473.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38597269" target="_blank">38597269</a><a href="/pmc/articles/PMC11005101" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37561012">Glucagon-Like Peptide 1 Analogues as Adjunctive Therapy for Patients With Type 1 Diabetes: An Updated Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Park J,
|
||
Ntelis S,
|
||
Yunasan E,
|
||
Downton KD,
|
||
Yip TC,
|
||
Munir KM,
|
||
Haq N</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 Dec 21;109(1):279-292.
|
||
doi: 10.1210/clinem/dgad471.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37561012" target="_blank">37561012</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37290044">Screening and Prevention of Type 1 Diabetes: Where Are We?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Simmons KM,
|
||
Sims EK</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 Nov 17;108(12):3067-3079.
|
||
doi: 10.1210/clinem/dgad328.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37290044" target="_blank">37290044</a><a href="/pmc/articles/PMC11491628" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/21218502">Changing epidemiologyof type 1 diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMjournal">Diabetes Metab Res Rev</span>
|
||
2011 Jan;27(1):1-2.
|
||
doi: 10.1002/dmrr.1167.
|
||
<span class="bold">PMID: </span><a href="/pubmed/21218502" target="_blank">21218502</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Type%201%20diabetes%20mellitus%2012%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (9860)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/39207742">Highs and Lows.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Durkin C</span><br />
|
||
<span class="medgenPMjournal">JAMA</span>
|
||
2024 Sep 24;332(12):965-966.
|
||
doi: 10.1001/jama.2024.13675.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39207742" target="_blank">39207742</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38597269">Association Between Type 1 Diabetes Mellitus and Eating Disorders: A Systematic Review and Meta-Analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dean YE,
|
||
Motawea KR,
|
||
Aslam M,
|
||
Pintado JJL,
|
||
Popoola-Samuel HAO,
|
||
Salam M,
|
||
Dundi POR,
|
||
Donaldy W,
|
||
Aledani EM,
|
||
Alqiqie Z,
|
||
Sultana N,
|
||
Mohamed ARH,
|
||
Elalem A,
|
||
Syeda STH,
|
||
Mohamed MS,
|
||
Assal MW,
|
||
Attia NM,
|
||
Hagar H,
|
||
Abdelaziz HA,
|
||
Subedi A,
|
||
Elbahaie A,
|
||
Hazimeh Y,
|
||
Aiash H</span><br />
|
||
<span class="medgenPMjournal">Endocrinol Diabetes Metab</span>
|
||
2024 May;7(3):e473.
|
||
doi: 10.1002/edm2.473.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38597269" target="_blank">38597269</a><a href="/pmc/articles/PMC11005101" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38048797">Screening type 1 diabetes and celiac disease by law.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bosi E,
|
||
Catassi C</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2024 Jan;12(1):12-14.
|
||
Epub 2023 Dec 1
|
||
doi: 10.1016/S2213-8587(23)00354-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38048797" target="_blank">38048797</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/37290044">Screening and Prevention of Type 1 Diabetes: Where Are We?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Simmons KM,
|
||
Sims EK</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 Nov 17;108(12):3067-3079.
|
||
doi: 10.1210/clinem/dgad328.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37290044" target="_blank">37290044</a><a href="/pmc/articles/PMC11491628" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31373146">Double diabetes: A distinct high-risk group?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kietsiriroje N,
|
||
Pearson S,
|
||
Campbell M,
|
||
Ariëns RAS,
|
||
Ajjan RA</span><br />
|
||
<span class="medgenPMjournal">Diabetes Obes Metab</span>
|
||
2019 Dec;21(12):2609-2618.
|
||
Epub 2019 Aug 19
|
||
doi: 10.1111/dom.13848.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31373146" target="_blank">31373146</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Type%201%20diabetes%20mellitus%2012%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4879)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38663944">Endpoints for clinical trials in type 1 diabetes drug development.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Galderisi A,
|
||
Marks BE,
|
||
DiMeglio LA,
|
||
de Beaufort C</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2024 May;12(5):297-299.
|
||
doi: 10.1016/S2213-8587(24)00097-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38663944" target="_blank">38663944</a><a href="/pmc/articles/PMC11230104" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/38602411">Safety and efficacy of teplizumab in the treatment of type 1 diabetes mellitus: An updated systematic review and meta-analysis of randomized controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Grando Alves G,
|
||
Cunha L,
|
||
Henkes Machado R,
|
||
Lins de Menezes V</span><br />
|
||
<span class="medgenPMjournal">Diabetes Obes Metab</span>
|
||
2024 Jul;26(7):2652-2661.
|
||
Epub 2024 Apr 11
|
||
doi: 10.1111/dom.15581.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38602411" target="_blank">38602411</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36493795">Continuous glucose monitoring and metrics for clinical trials: an international consensus statement.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Battelino T,
|
||
Alexander CM,
|
||
Amiel SA,
|
||
Arreaza-Rubin G,
|
||
Beck RW,
|
||
Bergenstal RM,
|
||
Buckingham BA,
|
||
Carroll J,
|
||
Ceriello A,
|
||
Chow E,
|
||
Choudhary P,
|
||
Close K,
|
||
Danne T,
|
||
Dutta S,
|
||
Gabbay R,
|
||
Garg S,
|
||
Heverly J,
|
||
Hirsch IB,
|
||
Kader T,
|
||
Kenney J,
|
||
Kovatchev B,
|
||
Laffel L,
|
||
Maahs D,
|
||
Mathieu C,
|
||
Mauricio D,
|
||
Nimri R,
|
||
Nishimura R,
|
||
Scharf M,
|
||
Del Prato S,
|
||
Renard E,
|
||
Rosenstock J,
|
||
Saboo B,
|
||
Ueki K,
|
||
Umpierrez GE,
|
||
Weinzimer SA,
|
||
Phillip M</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2023 Jan;11(1):42-57.
|
||
Epub 2022 Dec 6
|
||
doi: 10.1016/S2213-8587(22)00319-9.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36493795" target="_blank">36493795</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31585721">SGLT2 inhibitors as adjunctive therapy for type 1 diabetes: balancing benefits and risks.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Taylor SI,
|
||
Blau JE,
|
||
Rother KI,
|
||
Beitelshees AL</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2019 Dec;7(12):949-958.
|
||
Epub 2019 Oct 1
|
||
doi: 10.1016/S2213-8587(19)30154-8.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31585721" target="_blank">31585721</a><a href="/pmc/articles/PMC6872914" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29988125">Verapamil and beta cell function in adults with recent-onset type 1 diabetes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Ovalle F,
|
||
Grimes T,
|
||
Xu G,
|
||
Patel AJ,
|
||
Grayson TB,
|
||
Thielen LA,
|
||
Li P,
|
||
Shalev A</span><br />
|
||
<span class="medgenPMjournal">Nat Med</span>
|
||
2018 Aug;24(8):1108-1112.
|
||
Epub 2018 Jul 9
|
||
doi: 10.1038/s41591-018-0089-4.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29988125" target="_blank">29988125</a><a href="/pmc/articles/PMC6092963" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Type%201%20diabetes%20mellitus%2012%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (6411)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36786040">Type 1 diabetes incidence in Scotland between 2006 and 2019.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Thomson I,
|
||
Anderson N,
|
||
Bath L,
|
||
Kiff S,
|
||
Patterson C,
|
||
Philip S,
|
||
Waugh N,
|
||
Wild SH;
|
||
Scottish Study Group for the Care of Diabetes in the Young and the Scottish Diabetes Research Network Epidemiology Group</span><br />
|
||
<span class="medgenPMjournal">Diabet Med</span>
|
||
2023 Aug;40(8):e15069.
|
||
Epub 2023 Feb 25
|
||
doi: 10.1111/dme.15069.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36786040" target="_blank">36786040</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/35829805">The effect of type 1 diabetes mellitus on voice in pediatric patients.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kara I,
|
||
Temiz F,
|
||
Doganer A,
|
||
Sagıroglu S,
|
||
Yıldız MG,
|
||
Bilal N,
|
||
Orhan I</span><br />
|
||
<span class="medgenPMjournal">Eur Arch Otorhinolaryngol</span>
|
||
2023 Jan;280(1):269-275.
|
||
Epub 2022 Jul 13
|
||
doi: 10.1007/s00405-022-07543-z.
|
||
<span class="bold">PMID: </span><a href="/pubmed/35829805" target="_blank">35829805</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36113507">Global incidence, prevalence, and mortality of type 1 diabetes in 2021 with projection to 2040: a modelling study.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gregory GA,
|
||
Robinson TIG,
|
||
Linklater SE,
|
||
Wang F,
|
||
Colagiuri S,
|
||
de Beaufort C,
|
||
Donaghue KC;
|
||
International Diabetes Federation Diabetes Atlas Type 1 Diabetes in Adults Special Interest Group,
|
||
Magliano DJ,
|
||
Maniam J,
|
||
Orchard TJ,
|
||
Rai P,
|
||
Ogle GD</span><br />
|
||
<span class="medgenPMjournal">Lancet Diabetes Endocrinol</span>
|
||
2022 Oct;10(10):741-760.
|
||
Epub 2022 Sep 13
|
||
doi: 10.1016/S2213-8587(22)00218-2.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36113507" target="_blank">36113507</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19156571">Descriptive epidemiology of type 1 diabetes in youth: incidence, mortality, prevalence, and secular trends.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Green A</span><br />
|
||
<span class="medgenPMjournal">Endocr Res</span>
|
||
2008;33(1-2):1-15.
|
||
doi: 10.1080/07435800802079924.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19156571" target="_blank">19156571</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/9134344">Diabetes and obesity.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roth J</span><br />
|
||
<span class="medgenPMjournal">Diabetes Metab Rev</span>
|
||
1997 Mar;13(1):1-2.
|
||
doi: 10.1002/(sici)1099-0895(199703)13:1<1::aid-dmr179>3.0.co;2-q.
|
||
<span class="bold">PMID: </span><a href="/pubmed/9134344" target="_blank">9134344</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Type%201%20diabetes%20mellitus%2012%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (3938)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/37290044">Screening and Prevention of Type 1 Diabetes: Where Are We?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Simmons KM,
|
||
Sims EK</span><br />
|
||
<span class="medgenPMjournal">J Clin Endocrinol Metab</span>
|
||
2023 Nov 17;108(12):3067-3079.
|
||
doi: 10.1210/clinem/dgad328.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37290044" target="_blank">37290044</a><a href="/pmc/articles/PMC11491628" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29080981">Genetic Risk Scores for Type 1 Diabetes Prediction and Diagnosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Redondo MJ,
|
||
Oram RA,
|
||
Steck AK</span><br />
|
||
<span class="medgenPMjournal">Curr Diab Rep</span>
|
||
2017 Oct 28;17(12):129.
|
||
doi: 10.1007/s11892-017-0961-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29080981" target="_blank">29080981</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28923465">Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Feig DS,
|
||
Donovan LE,
|
||
Corcoy R,
|
||
Murphy KE,
|
||
Amiel SA,
|
||
Hunt KF,
|
||
Asztalos E,
|
||
Barrett JFR,
|
||
Sanchez JJ,
|
||
de Leiva A,
|
||
Hod M,
|
||
Jovanovic L,
|
||
Keely E,
|
||
McManus R,
|
||
Hutton EK,
|
||
Meek CL,
|
||
Stewart ZA,
|
||
Wysocki T,
|
||
O'Brien R,
|
||
Ruedy K,
|
||
Kollman C,
|
||
Tomlinson G,
|
||
Murphy HR;
|
||
CONCEPTT Collaborative Group</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2017 Nov 25;390(10110):2347-2359.
|
||
Epub 2017 Sep 15
|
||
doi: 10.1016/S0140-6736(17)32400-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28923465" target="_blank">28923465</a><a href="/pmc/articles/PMC5713979" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28682421">Exosomes as biomarkers and therapeutic tools for type 1 diabetes mellitus.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Garcia-Contreras M,
|
||
Brooks RW,
|
||
Boccuzzi L,
|
||
Robbins PD,
|
||
Ricordi C</span><br />
|
||
<span class="medgenPMjournal">Eur Rev Med Pharmacol Sci</span>
|
||
2017 Jun;21(12):2940-2956.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28682421" target="_blank">28682421</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19156572">Natural evolution, prediction, and prevention of type 1 diabetes in youth.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Taplin CE,
|
||
Barker JM</span><br />
|
||
<span class="medgenPMjournal">Endocr Res</span>
|
||
2008;33(1-2):17-33.
|
||
doi: 10.1080/07435800802080328.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19156572" target="_blank">19156572</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Type%201%20diabetes%20mellitus%2012%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (5368)</a></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_104">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/37997130">Autoimmune diseases and adverse pregnancy outcomes: an umbrella review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Singh M,
|
||
Wambua S,
|
||
Lee SI,
|
||
Okoth K,
|
||
Wang Z,
|
||
Fazla F,
|
||
Fayaz A,
|
||
Eastwood KA,
|
||
Nelson-Piercy C,
|
||
Nirantharakumar K,
|
||
Crowe F;
|
||
MuM-PreDiCT</span><br />
|
||
<span class="medgenPMjournal">Lancet</span>
|
||
2023 Nov;402 Suppl 1:S84.
|
||
doi: 10.1016/S0140-6736(23)02128-1.
|
||
<span class="bold">PMID: </span><a href="/pubmed/37997130" target="_blank">37997130</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/34348965">Effect of low glycaemic index or load dietary patterns on glycaemic control and cardiometabolic risk factors in diabetes: systematic review and meta-analysis of randomised controlled trials.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chiavaroli L,
|
||
Lee D,
|
||
Ahmed A,
|
||
Cheung A,
|
||
Khan TA,
|
||
Blanco S,
|
||
Mejia,
|
||
Mirrahimi A,
|
||
Jenkins DJA,
|
||
Livesey G,
|
||
Wolever TMS,
|
||
Rahelić D,
|
||
Kahleová H,
|
||
Salas-Salvadó J,
|
||
Kendall CWC,
|
||
Sievenpiper JL</span><br />
|
||
<span class="medgenPMjournal">BMJ</span>
|
||
2021 Aug 4;374:n1651.
|
||
doi: 10.1136/bmj.n1651.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34348965" target="_blank">34348965</a><a href="/pmc/articles/PMC8336013" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32568666">Psychological interventions to improve self-management of type 1 and type 2 diabetes: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Winkley K,
|
||
Upsher R,
|
||
Stahl D,
|
||
Pollard D,
|
||
Kasera A,
|
||
Brennan A,
|
||
Heller S,
|
||
Ismail K</span><br />
|
||
<span class="medgenPMjournal">Health Technol Assess</span>
|
||
2020 Jun;24(28):1-232.
|
||
doi: 10.3310/hta24280.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32568666" target="_blank">32568666</a><a href="/pmc/articles/PMC7336224" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/32142510">Dietary fibre and whole grains in diabetes management: Systematic review and meta-analyses.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Reynolds AN,
|
||
Akerman AP,
|
||
Mann J</span><br />
|
||
<span class="medgenPMjournal">PLoS Med</span>
|
||
2020 Mar;17(3):e1003053.
|
||
Epub 2020 Mar 6
|
||
doi: 10.1371/journal.pmed.1003053.
|
||
<span class="bold">PMID: </span><a href="/pubmed/32142510" target="_blank">32142510</a><a href="/pmc/articles/PMC7059907" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/23062861">Epidemiology of depression and diabetes: a systematic review.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Roy T,
|
||
Lloyd CE</span><br />
|
||
<span class="medgenPMjournal">J Affect Disord</span>
|
||
2012 Oct;142 Suppl:S8-21.
|
||
doi: 10.1016/S0165-0327(12)70004-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/23062861" target="_blank">23062861</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Type%201%20diabetes%20mellitus%2012%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (287)</a></div></div>
|
||
</div>
|
||
</div></div></div></div></div></div></div>
|
||
<div id="messagearea_bottom">
|
||
|
||
</div>
|
||
<div class=" bottom">
|
||
|
||
</div>
|
||
|
||
</div>
|
||
</div>
|
||
<div class="supplemental col three_col last">
|
||
<h2 class="offscreen_noflow">Supplemental Content</h2>
|
||
|
||
<div>
|
||
|
||
<!-- MedGen supplemental column starts here -->
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||
<div class="rightCol mgCol">
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<div class="portlet mgSection" id="ID_113">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Table_of_contents">Table of contents</h1><a sid="113" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet mgSection" id="ID_106">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Genetic_Testing_Registry">Genetic Testing Registry</h1><a sid="106" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><ul><li><a href="/gtr/tests?term=C1832392%5bDISCUI%5d&filter=method%3A2%5F8" target="_blank">Deletion/duplication analysis (17)</a></li>
|
||
<li><a href="/gtr/tests?term=C1832392%5bDISCUI%5d&filter=method%3A2%5F7" target="_blank">Sequence analysis of the entire coding region (13)</a></li>
|
||
<li><a href="/gtr/tests?term=C1832392%5bDISCUI%5d&filter=method%3A2%5F19" target="_blank">Targeted variant analysis (2)</a></li>
|
||
<li class="portletSeeAll portletSeeAllPad"><total><a href="/gtr/tests?term=C1832392%5bDISCUI%5d" target="_blank">See all (19)</a></total></li>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Clinical_resources">Clinical resources</h1><a sid="119" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=601388" target="_blank">OMIM</a></li><li><a href="https://clinicaltrials.gov/search?cond=Type%201%20diabetes%20mellitus%2012" target="_blank">ClinicalTrials.gov</a></li></ul></div>
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</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Practice_guidelines">Practice guidelines</h1><a sid="121" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul class="a_poppers"><li><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(type%201%20diabetes%20mellitus%2012)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">PubMed</a><div class="help-popup">See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div></li></ul></div>
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<div class="portlet mgSection" id="ID_115">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Molecular_resources">Molecular resources</h1><a sid="115" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="http://www.omim.org/search?index=entry&start=1&limit=10&sort=score%20desc&field=number&search=123890" target="_blank">OMIM</a></li><li><a href="/clinvar/?term=1493[geneid]" target="_blank">View CTLA4 variations in ClinVar</a></li><li><a href="/nuccore/224809308" target="_blank">RefSeqGene</a></li><li><a href="https://catalog.coriell.org/Search?q=601388" target="_blank">Coriell Institute for Medical Research</a></li></ul></div>
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||
</div>
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|
||
<div class="portlet mgSection" id="ID_116">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Consumer_resources">Consumer resources</h1><a sid="116" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln"><ul><li><a href="https://www.malacards.org/card/type_1_diabetes_mellitus_12" target="_blank">MalaCards</a></li><li><a href="https://vsearch.nlm.nih.gov/vivisimo/cgi-bin/query-meta?v:project=medlineplus&query=Type%201%20diabetes%20mellitus%2012" target="_blank">MedlinePlus</a></li><li><a href="https://medlineplus.gov/genetics/condition/type-1-diabetes" target="_blank">MedlinePlusGenetics (GHR)</a></li></ul></div>
|
||
</div>
|
||
</div>
|
||
<div class="portlet brieflink">
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||
<div class="portlet_head">
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<h3>Reviews</h3>
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<div class="portlet_content">
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<ul>
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||
<li>
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||
<a href="/pubmed/clinical?term=Type%201%20diabetes%20mellitus%2012" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=1&linkpostotal=2" target="_blank">PubMed Clinical Queries</a>
|
||
</li>
|
||
<li>
|
||
<a href="/pubmed?term=Type%201%20diabetes%20mellitus%2012%20AND%20humans[mesh]%20AND%20review[publication%20type]" ref="ncbi_uid=&discoId=gtr_reviews&linkpos=2&linkpostotal=2" target="_blank">Reviews in PubMed</a>
|
||
</li>
|
||
</ul>
|
||
</div>
|
||
</div>
|
||
|
||
<!-- MedGen supplemental column ends here -->
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||
<div class="portlet brieflink">
|
||
<div class="portlet_head">
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||
<div class="portlet_title">
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||
<h3>Related information</h3>
|
||
</div>
|
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||
</div>
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||
<div class="portlet_content DiscoveryDbLinks">
|
||
<ul>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/clinvar?LinkName=medgen_clinvar&from_uid=318618" ref="log$=recordlinks">ClinVar</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related medical variations</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gene?LinkName=medgen_gene_diseases&from_uid=318618" ref="log$=recordlinks">Gene</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in NCBI Gene</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1832392[DISCUI]" ref="log$=recordlinks">GTR</a>
|
||
<div class="brieflinkpop offscreen_noflow">Related information in GTR</div>
|
||
</li>
|
||
<li class="brieflinkpopper">
|
||
<a class="brieflinkpopperctrl" href="/gtr/tests?term=C1832392[DISCUI]&test_type=Clinical" ref="log$=recordlinks">GTR(Clinical)</a>
|
||
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