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<meta name="keywords" content="C1264195, myelodysplasia with sideroblastosis, myelodysplastic syndrome with ring sideroblasts, neoplastic process, pyridoxine refractory sideroblastic anemia, rars, refractory anaemia with ringed sideroblasts, refractory anemia with ringed sideroblasts, sideroblastic anemia pyridoxine-refractory autosomal recessive, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="A type of myelodysplastic syndrome characterized by less than 5% myeloblasts in the bone marrow, but with 15% or greater red cell precursors in the marrow being abnormal iron-stuffed cells called ringed sideroblasts." /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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||
UID=220394
|
||
ConceptID=C1264195
|
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-->
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Refractory anemia with ringed sideroblasts<span class="h1sub">(RARS)</span></div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>220394</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C1264195</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Neoplastic Process</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonyms:</td>
|
||
<td>Pyridoxine refractory sideroblastic anemia; RARS; Sideroblastic anemia pyridoxine-refractory autosomal recessive</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0004828">HP:0004828</a></td></tr>
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</tbody></table></div><div class="rprt-body jig-ncbiinpagenav" data-jigconfig="smoothScroll: false, gotoTopLink: true, gotoTopLinkText: '', gotoTopLinkAttrs: {'title': 'Go to the top of the page'},allHeadingLevels: ['h1'], topOfPageTOC: true, tocId: 'my-toc'"><div id="rprt-tabs-1" class="rprt-tab"><div id="tb-termsProp-1"><div class="leftCol mgCol"><div>
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||
<div class="portlet_content ln">A type of myelodysplastic syndrome characterized by less than 5% myeloblasts in the bone marrow, but with 15% or greater red cell precursors in the marrow being abnormal iron-stuffed cells called ringed sideroblasts. [from <a title="Human Phenotype Ontology" href="http://www.human-phenotype-ontology.org" class="defSource" target="_blank">HPO</a>]</div>
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="chiclet_list"><span class="chiclet Ccolor round" title="Clinical test"><a target="_blank" href="/gtr/tests/?term=C1264195[DISCUI]&test_type=Clinical" ref="ncbi_uid=220394">C</a></span><span class="chiclet unavailable round" title="Research Tests">R</span><span class="chiclet unavailable" title="OMIM">O</span><span class="chiclet unavailable" title="GeneReviews">G</span><span class="chiclet Vcolor" title="ClinVar"><a target="_blank" href="/clinvar?LinkName=medgen_clinvar&from_uid=220394" ref="ncbi_uid=220394">V</a></span></span><span class="TLline">Refractory anemia with ringed sideroblasts</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/208860" ref="tree=MeSH" title="MedGen record for Hematopoietic and Lymphatic System Disorder">Hematopoietic and Lymphatic System Disorder</a></span><ul><li><span class="TLline"><a href="/medgen/5483" ref="tree=MeSH" title="MedGen record for Hematologic disorder">Hematologic disorder</a></span><ul><li><span class="TLline"><a href="/medgen/2311" ref="tree=MeSH" title="MedGen record for Bone marrow disorder">Bone marrow disorder</a></span><ul><li><span class="TLline"><a href="/medgen/129203" ref="tree=MeSH" title="MedGen record for Bone marrow neoplasm">Bone marrow neoplasm</a></span><ul><li><span class="TLline"><a href="/medgen/438070" ref="tree=MeSH" title="MedGen record for Bone marrow cancer">Bone marrow cancer</a></span><ul><li><span class="TLline"><a href="/medgen/483005" ref="tree=MeSH" title="MedGen record for Myelodysplastic syndrome">Myelodysplastic syndrome</a></span><ul><li><span class="matched_ds">Refractory anemia with ringed sideroblasts</span><ul><li><span class="TLline"><a href="/medgen/226982" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia">Myelodysplastic Syndrome with Ring Sideroblasts and Multilineage Dysplasia</a></span></li><li><span class="TLline"><a href="/medgen/1378167" ref="tree=MeSH" title="MedGen record for Myelodysplastic Syndrome with Ring Sideroblasts and Single Lineage Dysplasia">Myelodysplastic Syndrome with Ring Sideroblasts and Single Lineage Dysplasia</a></span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
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<div class="portlet mgSection" id="ID_112">
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||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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<div class="portlet_content ln clinfeat">
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||
<div class="divPopper rprt" id="rdis_902781"><div><strong>Autosomal dominant sideroblastic anemia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>902781</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225428</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sideroblastic anemia comprises a heterogeneous group of inherited and acquired disorders characterized by ineffective erythropoiesis. Anemia, if present, may be microcytic or macrocytic. Sometimes a dimorphic picture is observed in which 2 populations of erythrocytes can be detected in peripheral blood smears. The presence of ringed sideroblasts (erythroblasts containing pathologic mitochondrial iron deposits) in bone marrow is pathognomonic for sideroblastic anemia (van Waveren Hogervorst et al., 1987; Schmitz-Abe et al., 2015). For a discussion of genetic heterogeneity of sideroblastic anemia, see SIDBA1 (300751).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/902781">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1790819"><div><strong>Erythroleukemia, familial, susceptibility to</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1790819</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5552985</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Familial erythroleukemia (FERLK) is a leukemic or preleukemic state in which red cell proliferation is the predominant feature. Hematologic characteristics include particularly ineffective and hyperplastic erythropoiesis with megaloblastic components accompanied by myeloblastic proliferation of varying degree (Park et al., 2002). Park et al. (2002) discussed the evolution of the definition of 'erythroleukemia,' which is considered by most to be a subtype of acute myelogenous leukemia (AML; 601626). Controversy about the precise definition of erythroleukemia revolves around the number or percentage of erythroblasts and myeloblasts found in the bone marrow and peripheral circulation. In the French-American-British (FAB) classification system (Bennett et al., 1985), it is known as AML-M6, whereas in the revised World Health Organization (WHO) classification system (Harris et al., 1999), it is known as 'AML, not otherwise categorized' (Zini and D'Onofrio, 2004).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1790819">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794195"><div><strong>Anemia, sideroblastic, 5</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794195</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561985</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Sideroblastic anemia-5 (SIDBA5) is an autosomal recessive hematologic disorder characterized by abnormal iron accumulation in the mitochondria or erythroid cells. The pathologic iron deposits appear to ring the nucleus, resulting in a 'ringed sideroblast' on pathologic examination. Affected individuals have congenital hypochromic microcytic anemia apparent in childhood; they may also develop thrombocytopenia or pancytopenia (summary by Crispin et al., 2020). For a discussion of genetic heterogeneity of sideroblastic anemia, see SIDBA1 (300751).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794195">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794195" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Anemia, sideroblastic, 5</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_902781" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Autosomal dominant sideroblastic anemia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1790819" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Erythroleukemia, familial, susceptibility to</a></div></div>
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||
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<div class="portlet mgSection" id="ID_105">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
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||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/25085359">Impact of the International Prognostic Scoring System cytogenetic risk groups on the outcome of patients with primary myelodysplastic syndromes undergoing allogeneic stem cell transplantation from human leukocyte antigen-identical siblings: a retrospective analysis of the European Society for Blood and Marrow Transplantation-Chronic Malignancies Working Party.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Onida F,
|
||
Brand R,
|
||
van Biezen A,
|
||
Schaap M,
|
||
von dem Borne PA,
|
||
Maertens J,
|
||
Beelen DW,
|
||
Carreras E,
|
||
Alessandrino EP,
|
||
Volin L,
|
||
Kuball JH,
|
||
Figuera A,
|
||
Sierra J,
|
||
Finke J,
|
||
Kröger N,
|
||
de Witte T;
|
||
MDS subcommittee of the EBMT-CMWP</span><br />
|
||
<span class="medgenPMjournal">Haematologica</span>
|
||
2014 Oct;99(10):1582-90.
|
||
Epub 2014 Aug 1
|
||
doi: 10.3324/haematol.2014.106880.
|
||
<span class="bold">PMID: </span><a href="/pubmed/25085359" target="_blank">25085359</a><a href="/pmc/articles/PMC4181254" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11304765">Hematopoietic stem-cell transplantation for treatment-related leukemia or myelodysplasia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Witherspoon RP,
|
||
Deeg HJ,
|
||
Storer B,
|
||
Anasetti C,
|
||
Storb R,
|
||
Appelbaum FR</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2001 Apr 15;19(8):2134-41.
|
||
doi: 10.1200/JCO.2001.19.8.2134.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11304765" target="_blank">11304765</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3524212">Management of myelodysplastic syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Buzaid AC,
|
||
Garewal HS,
|
||
Greenberg BR</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
1986 Jun;80(6):1149-57.
|
||
doi: 10.1016/0002-9343(86)90677-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3524212" target="_blank">3524212</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(%22refractory%20anemia%20with%20ringed%20sideroblasts%22%5Btiab%3A~0%5D)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (4)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/19692701">Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Malcovati L,
|
||
Della Porta MG,
|
||
Pietra D,
|
||
Boveri E,
|
||
Pellagatti A,
|
||
Gallì A,
|
||
Travaglino E,
|
||
Brisci A,
|
||
Rumi E,
|
||
Passamonti F,
|
||
Invernizzi R,
|
||
Cremonesi L,
|
||
Boultwood J,
|
||
Wainscoat JS,
|
||
Hellström-Lindberg E,
|
||
Cazzola M</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2009 Oct 22;114(17):3538-45.
|
||
Epub 2009 Aug 19
|
||
doi: 10.1182/blood-2009-05-222331.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19692701" target="_blank">19692701</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17194663">MPL W515 and JAK2 V617 mutation analysis in patients with refractory anemia with ringed sideroblasts and an elevated platelet count.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Steensma DP,
|
||
Caudill JS,
|
||
Pardanani A,
|
||
McClure RF,
|
||
Lasho TL,
|
||
Tefferi A</span><br />
|
||
<span class="medgenPMjournal">Haematologica</span>
|
||
2006 Dec;91(12 Suppl):ECR57.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17194663" target="_blank">17194663</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16741247">Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szpurka H,
|
||
Tiu R,
|
||
Murugesan G,
|
||
Aboudola S,
|
||
Hsi ED,
|
||
Theil KS,
|
||
Sekeres MA,
|
||
Maciejewski JP</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2006 Oct 1;108(7):2173-81.
|
||
Epub 2006 Jun 1
|
||
doi: 10.1182/blood-2006-02-005751.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16741247" target="_blank">16741247</a><a href="/pmc/articles/PMC1895556" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12841816">Thalidomide-induced sinus bradycardia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaur A,
|
||
Yu SS,
|
||
Lee AJ,
|
||
Chiao TB</span><br />
|
||
<span class="medgenPMjournal">Ann Pharmacother</span>
|
||
2003 Jul-Aug;37(7-8):1040-3.
|
||
doi: 10.1345/aph.1D003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12841816" target="_blank">12841816</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3409176">Hypoplastic myelodysplastic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nand S,
|
||
Godwin JE</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
1988 Sep 1;62(5):958-64.
|
||
doi: 10.1002/1097-0142(19880901)62:5<958::aid-cncr2820620519>3.0.co;2-p.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3409176" target="_blank">3409176</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Refractory%20anemia%20with%20ringed%20sideroblasts%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (71)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/20713854">Refractory anemia with ringed sideroblasts: more than meets the eye.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gill H,
|
||
Choi WW,
|
||
Kwong YL</span><br />
|
||
<span class="medgenPMjournal">J Clin Oncol</span>
|
||
2010 Nov 10;28(32):e654-5.
|
||
Epub 2010 Aug 16
|
||
doi: 10.1200/JCO.2010.29.5220.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20713854" target="_blank">20713854</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16741247">Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Szpurka H,
|
||
Tiu R,
|
||
Murugesan G,
|
||
Aboudola S,
|
||
Hsi ED,
|
||
Theil KS,
|
||
Sekeres MA,
|
||
Maciejewski JP</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2006 Oct 1;108(7):2173-81.
|
||
Epub 2006 Jun 1
|
||
doi: 10.1182/blood-2006-02-005751.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16741247" target="_blank">16741247</a><a href="/pmc/articles/PMC1895556" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/15034241">Coexistence of primary refractory anemia with ringed sideroblasts and T cell-lymphoblastic non-Hodgkin lymphoma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Dalamaga M,
|
||
Karmaniolas K,
|
||
Chavelas C,
|
||
Liatis S,
|
||
Ioannidis P,
|
||
Matekovits H,
|
||
Migdalis I</span><br />
|
||
<span class="medgenPMjournal">Acta Haematol</span>
|
||
2004;111(3):171-2.
|
||
doi: 10.1159/000076528.
|
||
<span class="bold">PMID: </span><a href="/pubmed/15034241" target="_blank">15034241</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10524457">Refractory anemia with ringed sideroblasts in children: two diseases with a similar phenotype?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan GC,
|
||
Head DR,
|
||
Wang WC</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
1999 Sep-Oct;21(5):418-23.
|
||
doi: 10.1097/00043426-199909000-00015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10524457" target="_blank">10524457</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3409176">Hypoplastic myelodysplastic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nand S,
|
||
Godwin JE</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
||
1988 Sep 1;62(5):958-64.
|
||
doi: 10.1002/1097-0142(19880901)62:5<958::aid-cncr2820620519>3.0.co;2-p.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3409176" target="_blank">3409176</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Refractory%20anemia%20with%20ringed%20sideroblasts%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (55)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30007103">Five-day regimen of azacitidine for lower-risk myelodysplastic syndromes (refractory anemia or refractory anemia with ringed sideroblasts): A prospective single-arm phase 2 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morita Y,
|
||
Maeda Y,
|
||
Yamaguchi T,
|
||
Urase F,
|
||
Kawata S,
|
||
Hanamoto H,
|
||
Tsubaki K,
|
||
Ishikawa J,
|
||
Shibayama H,
|
||
Matsumura I,
|
||
Matsuda M</span><br />
|
||
<span class="medgenPMjournal">Cancer Sci</span>
|
||
2018 Oct;109(10):3209-3215.
|
||
Epub 2018 Aug 26
|
||
doi: 10.1111/cas.13739.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30007103" target="_blank">30007103</a><a href="/pmc/articles/PMC6172056" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/14684416">The WHO classification of MDS does make a difference.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Howe RB,
|
||
Porwit-MacDonald A,
|
||
Wanat R,
|
||
Tehranchi R,
|
||
Hellström-Lindberg E</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2004 May 1;103(9):3265-70.
|
||
Epub 2003 Dec 18
|
||
doi: 10.1182/blood-2003-06-2124.
|
||
<span class="bold">PMID: </span><a href="/pubmed/14684416" target="_blank">14684416</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/12841816">Thalidomide-induced sinus bradycardia.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Kaur A,
|
||
Yu SS,
|
||
Lee AJ,
|
||
Chiao TB</span><br />
|
||
<span class="medgenPMjournal">Ann Pharmacother</span>
|
||
2003 Jul-Aug;37(7-8):1040-3.
|
||
doi: 10.1345/aph.1D003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/12841816" target="_blank">12841816</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/11005358">Pyoderma gangrenosum and myelodysplastic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Litvak D,
|
||
Kirsner RS,
|
||
Pakdaman NN,
|
||
Federman DG</span><br />
|
||
<span class="medgenPMjournal">South Med J</span>
|
||
2000 Sep;93(9):923-5.
|
||
<span class="bold">PMID: </span><a href="/pubmed/11005358" target="_blank">11005358</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3524212">Management of myelodysplastic syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Buzaid AC,
|
||
Garewal HS,
|
||
Greenberg BR</span><br />
|
||
<span class="medgenPMjournal">Am J Med</span>
|
||
1986 Jun;80(6):1149-57.
|
||
doi: 10.1016/0002-9343(86)90677-7.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3524212" target="_blank">3524212</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Refractory%20anemia%20with%20ringed%20sideroblasts%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (32)</a></div><h3 class="subhead">Prognosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/28466384">Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yoshimi A,
|
||
Abdel-Wahab O</span><br />
|
||
<span class="medgenPMjournal">Int J Hematol</span>
|
||
2017 Jun;105(6):720-731.
|
||
Epub 2017 May 2
|
||
doi: 10.1007/s12185-017-2242-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28466384" target="_blank">28466384</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/18166783">JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Schmitt-Graeff AH,
|
||
Teo SS,
|
||
Olschewski M,
|
||
Schaub F,
|
||
Haxelmans S,
|
||
Kirn A,
|
||
Reinecke P,
|
||
Germing U,
|
||
Skoda RC</span><br />
|
||
<span class="medgenPMjournal">Haematologica</span>
|
||
2008 Jan;93(1):34-40.
|
||
doi: 10.3324/haematol.11581.
|
||
<span class="bold">PMID: </span><a href="/pubmed/18166783" target="_blank">18166783</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/10524457">Refractory anemia with ringed sideroblasts in children: two diseases with a similar phenotype?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan GC,
|
||
Head DR,
|
||
Wang WC</span><br />
|
||
<span class="medgenPMjournal">J Pediatr Hematol Oncol</span>
|
||
1999 Sep-Oct;21(5):418-23.
|
||
doi: 10.1097/00043426-199909000-00015.
|
||
<span class="bold">PMID: </span><a href="/pubmed/10524457" target="_blank">10524457</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/3409176">Hypoplastic myelodysplastic syndrome.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Nand S,
|
||
Godwin JE</span><br />
|
||
<span class="medgenPMjournal">Cancer</span>
|
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1988 Sep 1;62(5):958-64.
|
||
doi: 10.1002/1097-0142(19880901)62:5<958::aid-cncr2820620519>3.0.co;2-p.
|
||
<span class="bold">PMID: </span><a href="/pubmed/3409176" target="_blank">3409176</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/2854694">Refractory anemia with ringed sideroblasts (primary acquired sideroblastic anemia).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Tomonaga M</span><br />
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||
<span class="medgenPMjournal">Nihon Ketsueki Gakkai Zasshi</span>
|
||
1988 Dec;51(8):1419-27.
|
||
<span class="bold">PMID: </span><a href="/pubmed/2854694" target="_blank">2854694</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Refractory%20anemia%20with%20ringed%20sideroblasts%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (57)</a></div><h3 class="subhead">Clinical prediction guides</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/30007103">Five-day regimen of azacitidine for lower-risk myelodysplastic syndromes (refractory anemia or refractory anemia with ringed sideroblasts): A prospective single-arm phase 2 trial.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morita Y,
|
||
Maeda Y,
|
||
Yamaguchi T,
|
||
Urase F,
|
||
Kawata S,
|
||
Hanamoto H,
|
||
Tsubaki K,
|
||
Ishikawa J,
|
||
Shibayama H,
|
||
Matsumura I,
|
||
Matsuda M</span><br />
|
||
<span class="medgenPMjournal">Cancer Sci</span>
|
||
2018 Oct;109(10):3209-3215.
|
||
Epub 2018 Aug 26
|
||
doi: 10.1111/cas.13739.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30007103" target="_blank">30007103</a><a href="/pmc/articles/PMC6172056" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28466384">Splicing factor mutations in MDS RARS and MDS/MPN-RS-T.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Yoshimi A,
|
||
Abdel-Wahab O</span><br />
|
||
<span class="medgenPMjournal">Int J Hematol</span>
|
||
2017 Jun;105(6):720-731.
|
||
Epub 2017 May 2
|
||
doi: 10.1007/s12185-017-2242-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28466384" target="_blank">28466384</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28300669">Enhanced plasma protein carbonylation in patients with myelodysplastic syndromes.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Hlaváčková A,
|
||
Štikarová J,
|
||
Pimková K,
|
||
Chrastinová L,
|
||
Májek P,
|
||
Kotlín R,
|
||
Čermák J,
|
||
Suttnar J,
|
||
Dyr JE</span><br />
|
||
<span class="medgenPMjournal">Free Radic Biol Med</span>
|
||
2017 Jul;108:1-7.
|
||
Epub 2017 Mar 12
|
||
doi: 10.1016/j.freeradbiomed.2017.03.007.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28300669" target="_blank">28300669</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/19692701">Molecular and clinical features of refractory anemia with ringed sideroblasts associated with marked thrombocytosis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Malcovati L,
|
||
Della Porta MG,
|
||
Pietra D,
|
||
Boveri E,
|
||
Pellagatti A,
|
||
Gallì A,
|
||
Travaglino E,
|
||
Brisci A,
|
||
Rumi E,
|
||
Passamonti F,
|
||
Invernizzi R,
|
||
Cremonesi L,
|
||
Boultwood J,
|
||
Wainscoat JS,
|
||
Hellström-Lindberg E,
|
||
Cazzola M</span><br />
|
||
<span class="medgenPMjournal">Blood</span>
|
||
2009 Oct 22;114(17):3538-45.
|
||
Epub 2009 Aug 19
|
||
doi: 10.1182/blood-2009-05-222331.
|
||
<span class="bold">PMID: </span><a href="/pubmed/19692701" target="_blank">19692701</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/16870250">Candidate gene mutation analysis in idiopathic acquired sideroblastic anemia (refractory anemia with ringed sideroblasts).</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Steensma DP,
|
||
Hecksel KA,
|
||
Porcher JC,
|
||
Lasho TL</span><br />
|
||
<span class="medgenPMjournal">Leuk Res</span>
|
||
2007 May;31(5):623-8.
|
||
Epub 2006 Jul 25
|
||
doi: 10.1016/j.leukres.2006.06.005.
|
||
<span class="bold">PMID: </span><a href="/pubmed/16870250" target="_blank">16870250</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Refractory%20anemia%20with%20ringed%20sideroblasts%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (58)</a></div></div>
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