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<meta name="keywords" content="C0521736, disease or syndrome, ectropion of lower eyelids, ectropion of lower lid, ectropion of the lower lid, everted lower eyelids, lower eyelid ectropion, lower eyelid folded out, lower eyelid turned out, autosomal dominant, autosomal recessive, birth defects, chromosomal disease, chromosome, clinical features, clinical findings, clinical genetics, clinical recommendations, clinvar, congenital chromosomal disease, consumer genetic resources, cytogenetic location, disease characteristics, disease definitions, disease descriptions, disease ontology, disease synonyms, disease vocabulary, dysmorphology, entrez, familial disease, gene, gene-disease relationship, genereviews, genetic disease, genetic disorder, genetic terminology, genetic testing registry, genetics home reference, genomic disease, gtr, hereditary disease, heritable disease, hpo, human phenotype ontology, inherited disease, management guidelines, maternal inheritance, medgen, medical genetics, medical subject headings, mesh, mitochondrial inheritance, mode of inheritance, national center for biotechnology information, national institutes of health, national library of medicine, ncbi, nih, nlm, omim, ordo, orphanet, paternal inheritance, phenome, position statements, professional practice guidelines, rare disease, reference sequence, refseq, snomed ct, syndrome, undiagnosed diseases, x-linked recessive" /><meta name="description" content="" /><meta name="robots" content="index,nofollow,noarchive" />
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<!--
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UID=636798
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ConceptID=C0521736
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<!--imgCountBooks = 0--><h1 class="medgenTitle"><div class="MedGenTitleText">Ectropion of lower eyelids</div></h1><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>636798</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information."><span class="highlight" style="background-color:">C0521736</span></a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div><table class="medgenTable"><tbody><tr><td>Synonym:</td>
|
||
<td>Ectropion of the lower lid</td></tr>
|
||
<tr><td><span class="bold">SNOMED CT: </span></td>
|
||
<td>Lower eyelid ectropion (95758006); Lower eyelid turned out (95758006); Ectropion of lower lid (95758006)</td></tr>
|
||
<tr><td colspan="2" class="small"> </td></tr><tr><td>HPO:</td>
|
||
<td><a target="_blank" title="Human Phenotype Ontology" href="https://hpo.jax.org/app/browse/term/HP:0007651">HP:0007651</a></td></tr>
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<div class="portlet mgSection" id="ID_118">
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Term_Hierarchy">Term Hierarchy</h1><a sid="118" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln HierarchyGTR"><div class="jig-ncbitabs"><ul><li><a href="#tabGTR">GTR</a></li><li><a href="#tabMGEN">MeSH</a></li></ul><div id="tabGTR"><div class="search_result"><div class="rprts"><div class="chiclet_legend"><span class="chiclet_list" style="position:static;"><span title="Clinical test" class="chiclet Ccolor round">C</span><span>Clinical test, </span><span title="Research test" class="chiclet Rcolor round">R</span><span>Research test, </span><span title="OMIM" class="chiclet Ocolor ">O</span><span>OMIM, </span><span title="GeneReview" class="chiclet Gcolor">G</span><span><em>GeneReviews</em>, </span><span title="ClinVar" class="chiclet Vcolor">V</span><span>ClinVar </span></span></div><div id="hierarchy" class="margin_t1"><div class="ds_tree"><ul><li class="matched_ds"><span class="TLline">Ectropion of lower eyelids</span></li></ul></div></div></div></div></div><div id="tabMGEN"><div class="ds_tree"><ul><li><span class="TLline"><a href="/medgen/871375" ref="tree=MeSH" title="MedGen record for Abnormality of the face">Abnormality of the face</a></span><ul><li><span class="TLline"><a href="/medgen/871367" ref="tree=MeSH" title="MedGen record for Abnormality of the orbital region">Abnormality of the orbital region</a></span><ul><li><span class="TLline"><a href="/medgen/1670962" ref="tree=MeSH" title="MedGen record for Abnormality of the ocular adnexa">Abnormality of the ocular adnexa</a></span><ul><li><span class="TLline"><a href="/medgen/893067" ref="tree=MeSH" title="MedGen record for Abnormal ocular adnexa morphology">Abnormal ocular adnexa morphology</a></span><ul><li><span class="TLline"><a href="/medgen/867429" ref="tree=MeSH" title="MedGen record for Abnormal eyelid morphology">Abnormal eyelid morphology</a></span><ul><li><span class="TLline"><a href="/medgen/4448" ref="tree=MeSH" title="MedGen record for Ectropion">Ectropion</a></span><ul><li><span class="matched_ds">Ectropion of lower eyelids</span></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></li></ul></div></div></div></div>
|
||
</div>
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||
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||
<div class="portlet mgSection" id="ID_112">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Conditions_with_this_feature">Conditions with this feature</h1><a sid="112" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln clinfeat">
|
||
<div class="divPopper rprt" id="rdis_98316"><div><strong>Mandibular prognathia</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>98316</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C0399526</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Finding</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Abnormal prominence of the chin related to increased length of the mandible.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/98316">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_767161"><div><strong>MEGF8-related Carpenter syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>767161</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C3554247</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Carpenter syndrome-2 (CRPT2) is an autosomal recessive multiple congenital malformation disorder characterized by multisuture craniosynostosis and polysyndactyly of the hands and feet, in association with abnormal left-right patterning and other features, most commonly obesity, umbilical hernia, cryptorchidism, and congenital heart disease (summary by Twigg et al., 2012). For a discussion of genetic heterogeneity of Carpenter syndrome, see 201000.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/767161">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_862975"><div><strong>ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>862975</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4014538</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">ADNP-related disorder is characterized by hypotonia, severe speech and motor delay, mild-to-severe intellectual disability, and characteristic facial features (prominent forehead, high anterior hairline, wide and depressed nasal bridge, and short nose with full, upturned nasal tip) based on a cohort of 78 individuals. Features of autism spectrum disorder are common (stereotypic behavior, impaired social interaction). Other common findings include additional behavioral problems, sleep disturbance, brain abnormalities, seizures, feeding issues, gastrointestinal problems, visual dysfunction (hypermetropia, strabismus, cortical visual impairment), musculoskeletal anomalies, endocrine issues including short stature and hormonal deficiencies, cardiac and urinary tract anomalies, and hearing loss.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/862975">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_909661"><div><strong>Orofacial cleft 15</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>909661</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4225209</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Congenital Abnormality</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Any cleft lip/palate in which the cause of the disease is a mutation in the DLX4 gene.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/909661">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1623594"><div><strong>Blepharocheilodontic syndrome 2</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1623594</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4540127</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Blepharocheilodontic (BCD) syndrome is a disorder that is present at birth. It mainly affects the eyelids (blepharo-), upper lip (-cheilo-), and teeth (-dontic).\n\nPeople with BCD syndrome have lower eyelids that turn out so that the inner surface is exposed (ectropion). The outside of the lower lid may sag away from the eye (euryblepharon), and the eyelids may not be able to close completely (lagophthalmia). There can be extra eyelashes (distichiasis) on the upper eyelids, ranging from a few extra eyelashes to a full extra set. These eyelashes do not grow along the edge of the eyelid with the normal lashes, but out of its inner lining. When the abnormal eyelashes touch the eyeball, they can cause damage to the clear covering of the eye (cornea). Affected individuals may also have widely spaced eyes (hypertelorism), a flat face, and a high forehead.\n\nOther features of BCD syndrome usually include openings on both sides of the upper lip (bilateral cleft lip) and an opening in the roof of the mouth (cleft palate). Affected individuals may have fewer teeth than normal (oligodontia) and their teeth are often smaller than usual and cone-shaped. The dental abnormalities affect both primary teeth (sometimes called "baby teeth") and secondary (permanent) teeth. Other frequent features include sparse, fine hair and abnormal nails.\n\nOccasionally people with BCD syndrome have additional features, including an obstruction of the anal opening (imperforate anus); malformation or absence of the butterfly-shaped gland in the lower neck called the thyroid, resulting in lack of thyroid gland function; or fused fingers or toes (syndactyly). Very rarely, affected individuals have incompletely formed arms or legs (limb reduction defects) or a spinal cord abnormality known as spina bifida.</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1623594">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1632198"><div><strong>Blepharocheilodontic syndrome 1</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1632198</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C4551988</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">The blepharocheilodontic syndrome is a rare autosomal dominant disorder characterized by lower eyelid ectropion, upper eyelid distichiasis, euryblepharon, bilateral cleft lip and palate, and conical teeth. An additional rare manifestation is imperforate anus (summary by Weaver et al., 2010).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1632198">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1794156"><div><strong>Luo-Schoch-Yamamoto syndrome</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1794156</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5561946</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Luo-Schoch-Yamamoto syndrome (LUSYAM) is a neurodevelopmental disorder characterized by global developmental delay and impaired intellectual development apparent from infancy. Affected individuals have delayed walking, early-onset seizures, hypotonia, dysmorphic facial features, and white matter abnormalities on brain imaging (Luo et al., 2021).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1794156">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1857168"><div><strong>Cutis laxa, autosomal recessive, type 1d</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1857168</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935602</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">Autosomal recessive cutis laxa type ID (ARCL1D) is characterized by facial dysmorphism, joint hypermobility, muscle hypotonia, and multiple severe herniations, including inguinal, ventral, diaphragmatic, sciatic, and obturator, as well as large diverticula of the gastrointestinal tract and urinary bladder. The skin is thin and translucent with easy bruising; the degree of laxity is variable and progresses with age in some patients (Megarbane et al., 2012; Bizzari et al., 2020; Driver et al., 2020; Verlee et al., 2021). For a general phenotypic description and discussion of genetic heterogeneity of autosomal recessive cutis laxa, see ARCL1A (219100).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1857168">Condition Record</a></div></div>
|
||
<div class="divPopper rprt" id="rdis_1854654"><div><strong>Neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language</strong><div class="aux"><div class="resc"><dl class="rprtid"><dt>MedGen UID: </dt><dd>1854654</dd><dt><span class="dotprefix"> •</span>Concept ID: </dt><dd><a href="/medgen/docs/help/#sources" target="_blank" title="Concept Unique Identifier from NLM's Unified Medical Language system (UMLS) Click for more information.">C5935628</a></dd><dt><span class="dotprefix"> •</span></dt><dd>Disease or Syndrome</dd></dl></div></div></div>
|
||
<div class="spaceAbove">ReNU syndrome (RENU), also known as neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language (NEDHAFA), is characterized by hypotonia, global developmental delay, severely impaired intellectual development with poor or absent speech, delayed walking or inability to walk, feeding difficulties with poor overall growth, seizures (in most), dysmorphic facial features, and brain anomalies, including ventriculomegaly, thin corpus callosum, and progressive white matter loss (Greene et al., 2024; Schot et al., 2024; Chen et al., 2024).</div>
|
||
<div class="spaceAbove nowrap">See: <a href="/medgen/1854654">Condition Record</a></div></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_862975" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1632198" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Blepharocheilodontic syndrome 1</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1623594" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Blepharocheilodontic syndrome 2</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1857168" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Cutis laxa, autosomal recessive, type 1d</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1794156" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Luo-Schoch-Yamamoto syndrome</a></div><div class="jig-moreless" data-jigconfig="class: 'moveDown', moreText: 'See full list (9)', lessText: 'Show less', nodeBefore: 0"><span id="clinMore">
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_98316" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Mandibular prognathia</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_767161" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">MEGF8-related Carpenter syndrome</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_1854654" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Neurodevelopmental disorder with hypotonia, brain anomalies, distinctive facies, and absent language</a></div>
|
||
<div class="hangingIndent"><a title="click for more information" class="jig-ncbipopper" href="#rdis_909661" data-jigconfig="hasArrow: true, openEvent: 'click', closeEvent: 'mouseout', openAnimation: 'fadeIn', closeAnimation: 'fadeOut', triggerPosition: 'center right', destPosition: 'center left', arrowDirection: 'left'">Orofacial cleft 15</a></div></span></div></div>
|
||
</div>
|
||
|
||
<div class="portlet mgSection" id="ID_105">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Professional_guidelines">Professional guidelines</h1><a sid="105" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">PubMed<a class="help jig-ncbi-popper" data-jig="ncbipopper" href="#guidelinesHelpPM"><img class="pulldown" src="//static.pubmed.gov/portal/portal3rc.fcgi/4223267/img/4204968" /></a></h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/36053479">Involutional ectropion: etiological factors and therapeutic management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">AlHarthi AS</span><br />
|
||
<span class="medgenPMjournal">Int Ophthalmol</span>
|
||
2023 Mar;43(3):1013-1026.
|
||
Epub 2022 Sep 2
|
||
doi: 10.1007/s10792-022-02475-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36053479" target="_blank">36053479</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28005755">Management of Zygomatic Fractures in Young Patients: Technical Modifications for Aesthetic and Functional Results.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Cortese A,
|
||
D'Alessio G,
|
||
Brongo S,
|
||
Gargiulo M,
|
||
Claudio PP</span><br />
|
||
<span class="medgenPMjournal">J Craniofac Surg</span>
|
||
2016 Nov;27(8):2073-2077.
|
||
doi: 10.1097/SCS.0000000000003034.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28005755" target="_blank">28005755</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/24063354">Use of hyaluronic acid gel in the management of cicatricial ectropion: results and complications.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Romero R,
|
||
Sanchez-Orgaz M,
|
||
Granados M,
|
||
Arbizu A,
|
||
Castano A,
|
||
Romero A,
|
||
Molia P</span><br />
|
||
<span class="medgenPMjournal">Orbit</span>
|
||
2013 Dec;32(6):362-5.
|
||
Epub 2013 Sep 24
|
||
doi: 10.3109/01676830.2013.833250.
|
||
<span class="bold">PMID: </span><a href="/pubmed/24063354" target="_blank">24063354</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=(ectropion%20of%20lower%20eyelids)%20AND%20(%22english%20and%20humans%22%5BFilter%5D)%20AND%20(%20(%22practice%20guideline%22%5BFilter%5D)%20OR%20(practice*%5Btitl%5D%20AND%20(guideline%5Btitl%5D%20OR%20parameter%5Btitl%5D%20OR%20resource%5Btitl%5D%20OR%20bulletin%5Btitl%5D%20OR%20best%5Btitl%5D))%20OR%20(genetic*%5Btitl%5D%20AND%20(evaluation%5Btitl%5D%20OR%20counseling%5Btitl%5D%20OR%20screening%5Btitl%5D%20OR%20test*%5Btitl%5D))%20OR%20(clinical%5Btitl%5D%20AND%20((expert%5Btitl%5D%20AND%20consensus%5Btitl%5D)%20OR%20utility%5Btitl%5D%20OR%20guideline*%5Btitl%5D))%20OR%20(management%5Btitl%5D%20AND%20(clinical%5Btitl%5D%20OR%20diagnos*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20pain%5Btitl%5D%20OR%20surveillance%5Btitl%5D%20OR%20emergency%5Btitl%5D%20OR%20guideline*%5Btitl%5D%20OR%20therap*))%20OR%20(treatment%5Btitl%5D%20AND%20((evaluation%5Btitl%5D%20AND%20diagnosis%5Btitl%5D)%20OR%20(assessment%5Btitl%5D%20AND%20prevention%5Btitl%5D)%20OR%20therap*))%20OR%20(Diagnos*%5Btitl%5D%20AND%20(prenatal%5Btitl%5D%20OR%20treatment%5Btitl%5D%20OR%20follow-up%5Btitl%5D%20OR%20statement%5Btitl%5D%20OR%20criteria%5Btitl%5D%20OR%20newborn%5Btitl%5D%20OR%20differential%5Btitl%5D%20OR%20neonatal%5Btitl%5D%20OR%20neonate%5Btitl%5D))%20OR%20(guideline*%5Btitl%5D%20AND%20(pharmacogenetic*%5Btitl%5D%20OR%20recommendation%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20evidence-based%5Btitl%5D%20OR%20consensus%5Btitl%5D%20OR%20(technical%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20(molecular%5Btitl%5D%20AND%20testing%5Btitl%5D)))%20OR%20(risk%5Btitl%5D%20AND%20assessment%5Btitl%5D)%20OR%20(recommendation*%5Btitl%5D%20AND%20(statement%5Btitl%5D%20OR%20Evidence-based%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(care%20AND%20((Patient%5Btitl%5D%20AND%20standard*%5Btitl%5D)%20OR%20primary%5Btitl%5D%20OR%20psychosocial%5Btitl%5D))%20OR%20(Health%5Btitl%5D%20AND%20supervision%5Btitl%5D)%20OR%20(statement%5Btitl%5D%20AND%20(policy%5Btitl%5D%20OR%20position%5Btitl%5D%20OR%20Consensus%5Btitl%5D))%20OR%20(pharmacogenetics%5Btitl%5D%20AND%20(Dosing%5Btitl%5D%20OR%20therap*%5Btitl%5D%20OR%20genotype*%5Btitl%5D%20OR%20drug*%5Btitl%5D))%20OR%20(Chemotherapy%5Btitl%5D%20AND%20decision*%5Btitl%5D)%20OR%20(screening%5Btitl%5D%20AND%20(newborn%5Btitl%5D%20OR%20neonat*%5Btitl%5D%20OR%20detection%5Btitl%5D%20OR%20diagnos*%5Btitl%5D))%20OR%20(criteria%5Btitl%5D%20OR%20genotype*%5Btitl%5D)%20)%20NOT%20(%22Case%20reports%22%5BPublication%20type%5D%20OR%20%22clinical%20study%22%5BPublication%20Type%5D%20OR%20%22randomized%20controlled%20trial%22%5BPublication%20Type%5D)" title="PubMed search">See all (13)</a></div></div>
|
||
</div>
|
||
<div class="display-none help-popup" id="guidelinesHelpPM">These guidelines are articles in PubMed that match specific search criteria developed by MedGen to capture the most relevant practice guidelines. This list may not be comprehensive and may include broader topics as well. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div><div class="display-none help-popup" id="guidelinesHelpCurated">These guidelines are manually curated by the MedGen team
|
||
to supplement articles available in PubMed. See the <a href="/medgen/docs/faq/" title="Frequently asked questions" target="_blank">FAQ</a> for details.</div>
|
||
<div class="portlet mgSection" id="ID_103">
|
||
<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_clinical_studies">Recent clinical studies</h1><a sid="103" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln"><h3 class="subhead">Etiology</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/38629275">Evaluation of outcomes of lower eyelid entropion and ectropion surgical repair.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Woźniak-Roszkowska E,
|
||
Iljin A,
|
||
Noszczyk B,
|
||
Antoszewski B</span><br />
|
||
<span class="medgenPMjournal">Pol Przegl Chir</span>
|
||
2023 Oct 17;96(2):50-58.
|
||
doi: 10.5604/01.3001.0053.9352.
|
||
<span class="bold">PMID: </span><a href="/pubmed/38629275" target="_blank">38629275</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36906696">The surgical management and outcomes of kissing nevi of the eyelids.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Zloto O,
|
||
Landau Prat D,
|
||
Katowitz JA,
|
||
Katowitz WR,
|
||
Ben Simon G,
|
||
Verity DH</span><br />
|
||
<span class="medgenPMjournal">Eye (Lond)</span>
|
||
2023 Oct;37(14):3015-3019.
|
||
Epub 2023 Mar 11
|
||
doi: 10.1038/s41433-023-02463-6.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36906696" target="_blank">36906696</a><a href="/pmc/articles/PMC10517166" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36053479">Involutional ectropion: etiological factors and therapeutic management.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">AlHarthi AS</span><br />
|
||
<span class="medgenPMjournal">Int Ophthalmol</span>
|
||
2023 Mar;43(3):1013-1026.
|
||
Epub 2022 Sep 2
|
||
doi: 10.1007/s10792-022-02475-3.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36053479" target="_blank">36053479</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29195240">Repair of the Malpositioned Lower Lid.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan D,
|
||
Sokoya M,
|
||
Ducic Y</span><br />
|
||
<span class="medgenPMjournal">Facial Plast Surg</span>
|
||
2017 Dec;33(6):598-605.
|
||
Epub 2017 Dec 1
|
||
doi: 10.1055/s-0037-1608711.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29195240" target="_blank">29195240</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17182405">Complications of blepharoplasty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morax S,
|
||
Touitou V</span><br />
|
||
<span class="medgenPMjournal">Orbit</span>
|
||
2006 Dec;25(4):303-18.
|
||
doi: 10.1080/01676830600985841.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17182405" target="_blank">17182405</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ectropion%20of%20lower%20eyelids%22%20AND%20Etiology%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (331)</a></div><h3 class="subhead">Diagnosis</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/34812179">Lower Eyelid Ectropion Secondary to Over-the-Counter Treatment of Xanthelasma.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Salloum G,
|
||
Crawford JJ,
|
||
Dryden S,
|
||
Meador AG,
|
||
Wesley RE,
|
||
Klippenstein K</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Plast Reconstr Surg</span>
|
||
2022 Jan-Feb 01;38(1):e25-e28.
|
||
doi: 10.1097/IOP.0000000000002070.
|
||
<span class="bold">PMID: </span><a href="/pubmed/34812179" target="_blank">34812179</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/29195240">Repair of the Malpositioned Lower Lid.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Chan D,
|
||
Sokoya M,
|
||
Ducic Y</span><br />
|
||
<span class="medgenPMjournal">Facial Plast Surg</span>
|
||
2017 Dec;33(6):598-605.
|
||
Epub 2017 Dec 1
|
||
doi: 10.1055/s-0037-1608711.
|
||
<span class="bold">PMID: </span><a href="/pubmed/29195240" target="_blank">29195240</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/20165966">Retrospective analysis of orbital floor fractures--complications, outcome, and review of literature.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Gosau M,
|
||
Schöneich M,
|
||
Draenert FG,
|
||
Ettl T,
|
||
Driemel O,
|
||
Reichert TE</span><br />
|
||
<span class="medgenPMjournal">Clin Oral Investig</span>
|
||
2011 Jun;15(3):305-13.
|
||
Epub 2010 Feb 18
|
||
doi: 10.1007/s00784-010-0385-y.
|
||
<span class="bold">PMID: </span><a href="/pubmed/20165966" target="_blank">20165966</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17182405">Complications of blepharoplasty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morax S,
|
||
Touitou V</span><br />
|
||
<span class="medgenPMjournal">Orbit</span>
|
||
2006 Dec;25(4):303-18.
|
||
doi: 10.1080/01676830600985841.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17182405" target="_blank">17182405</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/6614752">Prevention of ectropion by horizontal shortening of the lower lid during blepharoplasty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Rees TD</span><br />
|
||
<span class="medgenPMjournal">Ann Plast Surg</span>
|
||
1983 Jul;11(1):17-23.
|
||
doi: 10.1097/00000637-198307000-00003.
|
||
<span class="bold">PMID: </span><a href="/pubmed/6614752" target="_blank">6614752</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ectropion%20of%20lower%20eyelids%22%20AND%20Diagnosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (103)</a></div><h3 class="subhead">Therapy</h3>
|
||
<div class="nl"><a target="_blank" href="/pubmed/31587762">Management of Postblepharoplasty Lower Eyelid Retraction.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Patel A,
|
||
Wang Y,
|
||
Massry GG</span><br />
|
||
<span class="medgenPMjournal">Facial Plast Surg Clin North Am</span>
|
||
2019 Nov;27(4):425-434.
|
||
Epub 2019 Aug 30
|
||
doi: 10.1016/j.fsc.2019.07.014.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31587762" target="_blank">31587762</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/30084870">Lower Eyelid Blepharoplasty: Does the Literature Support the Longevity of this Procedure?</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Wilson SC,
|
||
Daar DA,
|
||
Maliha SG,
|
||
Abdou SA,
|
||
Levine SM,
|
||
Baker DC</span><br />
|
||
<span class="medgenPMjournal">Aesthet Surg J</span>
|
||
2018 Nov 12;38(12):1289-1297.
|
||
doi: 10.1093/asj/sjy186.
|
||
<span class="bold">PMID: </span><a href="/pubmed/30084870" target="_blank">30084870</a></div>
|
||
|
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<div class="nl"><a target="_blank" href="/pubmed/29979234">Management of a Lower Eyelid Defect.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Tinklepaugh A,
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<span class="bold">PMID: </span><a href="/pubmed/28509671" target="_blank">28509671</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/3942552">Blastomycosis of the eyelid.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Barr CC,
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<span class="medgenPMjournal">Arch Ophthalmol</span>
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<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ectropion%20of%20lower%20eyelids%22%20AND%20Therapy%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (138)</a></div><h3 class="subhead">Prognosis</h3>
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<div class="nl"><a target="_blank" href="/pubmed/29369905">Floppy Eyelid Syndrome: An Unfamiliar Entity for Plastic Surgeons.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Lee CC,
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Lai HT,
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Kuo YR,
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Lee SS,
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2018 Feb;80(2S Suppl 1):S40-S47.
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<div class="nl"><a target="_blank" href="/pubmed/29195240">Repair of the Malpositioned Lower Lid.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Chan D,
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Ducic Y</span><br />
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<span class="medgenPMjournal">Facial Plast Surg</span>
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2017 Dec;33(6):598-605.
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Epub 2017 Dec 1
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doi: 10.1055/s-0037-1608711.
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<span class="bold">PMID: </span><a href="/pubmed/29195240" target="_blank">29195240</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/27348642">Pretarsal Augmented Lower Blepharoplasty.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Jeon YR,
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Rah DK,
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Lew DH,
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Roh TS,
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Kim YS,
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<span class="medgenPMjournal">Plast Reconstr Surg</span>
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2016 Jul;138(1):74-82.
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<span class="bold">PMID: </span><a href="/pubmed/27348642" target="_blank">27348642</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/26020720">Recession and Extirpation of the Lower Eyelid Retractors for Paralytic Lagophthalmos.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Compton CJ,
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Clark JD,
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Nunery WR,
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<span class="medgenPMjournal">Ophthalmic Plast Reconstr Surg</span>
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2015 Jul-Aug;31(4):323-4.
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doi: 10.1097/IOP.0000000000000485.
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<span class="bold">PMID: </span><a href="/pubmed/26020720" target="_blank">26020720</a></div>
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||
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||
<div class="nl"><a target="_blank" href="/pubmed/20489545">Aesthetic lateral canthoplasty.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Taban M,
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Nakra T,
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Hwang C,
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Hoenig JA,
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Douglas RS,
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Shorr N,
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2010 May-Jun;26(3):190-4.
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doi: 10.1097/IOP.0b013e3181baa23f.
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<span class="bold">PMID: </span><a href="/pubmed/20489545" target="_blank">20489545</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ectropion%20of%20lower%20eyelids%22%20AND%20Prognosis%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (124)</a></div><h3 class="subhead">Clinical prediction guides</h3>
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||
<div class="nl"><a target="_blank" href="/pubmed/38668033">Complications and Recurrences after Excision and Reconstruction of Eyelid Tumours.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Balchev G</span><br />
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<span class="medgenPMjournal">Curr Oncol</span>
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2024 Mar 22;31(4):1713-1724.
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doi: 10.3390/curroncol31040130.
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<span class="bold">PMID: </span><a href="/pubmed/38668033" target="_blank">38668033</a><a href="/pmc/articles/PMC11049131" target="_blank" class="PubMedFree">Free PMC Article</a></div>
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||
<div class="nl"><a target="_blank" href="/pubmed/38629275">Evaluation of outcomes of lower eyelid entropion and ectropion surgical repair.</a></div>
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<div class="portlet_content ln"><span class="medgenPMauthor">Woźniak-Roszkowska E,
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Iljin A,
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2023 Oct 17;96(2):50-58.
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<span class="bold">PMID: </span><a href="/pubmed/38629275" target="_blank">38629275</a></div>
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<div class="nl"><a target="_blank" href="/pubmed/36906696">The surgical management and outcomes of kissing nevi of the eyelids.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Zloto O,
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Landau Prat D,
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Katowitz JA,
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Katowitz WR,
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Ben Simon G,
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||
Verity DH</span><br />
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<span class="medgenPMjournal">Eye (Lond)</span>
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||
2023 Oct;37(14):3015-3019.
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Epub 2023 Mar 11
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doi: 10.1038/s41433-023-02463-6.
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<span class="bold">PMID: </span><a href="/pubmed/36906696" target="_blank">36906696</a><a href="/pmc/articles/PMC10517166" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36342769">Intraorbital Fixation Midface Lift.</a></div>
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||
<div class="portlet_content ln"><span class="medgenPMauthor">Bitik O</span><br />
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<span class="medgenPMjournal">Aesthet Surg J</span>
|
||
2023 Feb 21;43(3):269-286.
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||
doi: 10.1093/asj/sjac289.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36342769" target="_blank">36342769</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/17182405">Complications of blepharoplasty.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Morax S,
|
||
Touitou V</span><br />
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<span class="medgenPMjournal">Orbit</span>
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2006 Dec;25(4):303-18.
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||
doi: 10.1080/01676830600985841.
|
||
<span class="bold">PMID: </span><a href="/pubmed/17182405" target="_blank">17182405</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ectropion%20of%20lower%20eyelids%22%20AND%20Clinical%20prediction%20guides%2Fbroad%5Bfilter%5D%20%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (107)</a></div></div>
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||
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|
||
|
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<div class="portlet mgSection" id="ID_104">
|
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<div class="portlet_head mgSectionHead ui-widget-header"><h1 class="nl" id="Recent_systematic_reviews">Recent systematic reviews</h1><a sid="104" href="#" class="portlet_shutter" title="Show/hide content"></a></div>
|
||
<div class="portlet_content ln">
|
||
<div class="nl"><a target="_blank" href="/pubmed/39631150">Towards optimal management of lower eyelid malpositions: A systematic review of treatment effectiveness and safety.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Sbitan L,
|
||
Tanous H,
|
||
Jardak MN,
|
||
Camargo CP</span><br />
|
||
<span class="medgenPMjournal">Clinics (Sao Paulo)</span>
|
||
2025;80:100547.
|
||
Epub 2024 Dec 3
|
||
doi: 10.1016/j.clinsp.2024.100547.
|
||
<span class="bold">PMID: </span><a href="/pubmed/39631150" target="_blank">39631150</a><a href="/pmc/articles/PMC11652735" target="_blank" class="PubMedFree">Free PMC Article</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/36700854">Prevalence of Obstructive Sleep Apnea With Floppy Eyelid Syndrome: A Systematic Review and Meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Bulloch G,
|
||
Seth I,
|
||
Alphonse S,
|
||
Sathe A,
|
||
Jennings M,
|
||
Sultan D,
|
||
Rahmeh R,
|
||
McNab AA</span><br />
|
||
<span class="medgenPMjournal">Ophthalmic Plast Reconstr Surg</span>
|
||
2023 May-Jun 01;39(3):243-253.
|
||
Epub 2022 Oct 28
|
||
doi: 10.1097/IOP.0000000000002298.
|
||
<span class="bold">PMID: </span><a href="/pubmed/36700854" target="_blank">36700854</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/31584117">Approach to treatment of cicatricial ectropion: a systematic review and meta-analysis comparing surgical and minimally invasive options.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Worley B,
|
||
Huang JW,
|
||
Macdonald J</span><br />
|
||
<span class="medgenPMjournal">Arch Dermatol Res</span>
|
||
2020 Apr;312(3):165-172.
|
||
Epub 2019 Oct 4
|
||
doi: 10.1007/s00403-019-01983-0.
|
||
<span class="bold">PMID: </span><a href="/pubmed/31584117" target="_blank">31584117</a></div>
|
||
|
||
<div class="nl"><a target="_blank" href="/pubmed/28823598">Subciliary vs. transconjunctival approach for the management of orbital floor and periorbital fractures: A systematic review and meta-analysis.</a></div>
|
||
<div class="portlet_content ln"><span class="medgenPMauthor">Al-Moraissi EA,
|
||
Thaller SR,
|
||
Ellis E</span><br />
|
||
<span class="medgenPMjournal">J Craniomaxillofac Surg</span>
|
||
2017 Oct;45(10):1647-1654.
|
||
Epub 2017 Jul 19
|
||
doi: 10.1016/j.jcms.2017.07.004.
|
||
<span class="bold">PMID: </span><a href="/pubmed/28823598" target="_blank">28823598</a></div>
|
||
<div><a target="_blank" href="https://pubmed.ncbi.nlm.nih.gov/?term=%22Ectropion%20of%20lower%20eyelids%22%20AND%20systematic%5Bsb%5D%20AND%20%22english%20and%20humans%22%5Bfilter%5D%20NOT%20comment%5BPTYP%5D%20NOT%20letter%5BPTYP%5D" title="PubMed search">See all (4)</a></div></div>
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<h2 class="offscreen_noflow">Supplemental Content</h2>
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